Unique_ID	Origin_ID	Sequence	Activity	Source	Structure	Hemolysis	Reference	Length	Stereo
FPDB00001	AP00001|||2846|||2847|||2848|||2849|||2850|||AP00001|||Adenoregulin|||DRAMP01646|||Adenoregulin|||AP00001|||DRAMP01646	GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV	Anti-M. canis IP 1194, activity value is MIC = 10 ug/ml||Anti-T. rubrum IP 1400-82, activity value is MIC = 15 ug/ml||Anti-A. fumigatus IP 1025-70, activity value is MIC = 125 ug/ml||Anti-A. simii IP 1063-74, activity value is MIC = 30 ug/ml||Anti-A. caviae IP 67-16 T, activity value is MIC = 60 ug/ml||Anti-E. coli IP 76-24, activity value is MIC = 15 ug/ml||Anti-P. aeruginosa, activity value is MIC = 3.1 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 0.7 uM||Anti-N. brasiliensis IP 16-80, activity value is MIC = 30 ug/ml||Anti-C. neoformans IP 960-67 or IP 962-67, activity value is MIC = 15 ug/ml||Anti-and C. albicans, activity value is MIC = 15 ug/ml||activity value is GI50 = 1.24||activity value is GI50 = 0.31||activity value is GI50 = 0.91||activity value is GI50 = 8.06||activity value is GI50 = 2.57||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anticancer||Antibacterial||Anti-Microsporum canis, activity value is MIC = 10 ug/ml||Anti-Tricophyton rubrum, activity value is MIC = 15 ug/ml||Anti-Arthroderma simii, activity value is MIC = 30 ug/ml||Anti-Aspergillus fumigatus IP, activity value is MIC = 125 ug/ml||Anti-Aerornonas caviae, activity value is MIC = 60 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 15 ug/ml||Anti-Candida albicans, activity value is MIC = 15 ug/ml||Anti-Escherichia coli, activity value is MIC = 15 ug/ml||Anti-Nocardia brasiliensis, activity value is MIC = 30 ug/ml||Anti-usporum canis IP 11 94, activity value is MIC = 10 ug/ml||Anti-Tricophyton rubrum IP 1400-82, activity value is MIC = 15 ug/ml||Anti-Arthroderma simii IP 1063-74, activity value is MIC = 30 ug/ml||Anti-Aspergillus fumigatus IP 1025-70, activity value is MIC = 125 ug/ml||Anti-Aerornonas caviae IP 67-16 T, activity value is MIC = 60 ug/ml||Anti-Escherichia coli IP 76-24, activity value is MIC = 15 ug/ml||Anti-Nocardia brasiliensis IP 16-80, activity value is MIC = 30 ug/ml||Anti-Cryptococcus neoformans IP 960-67, activity value is MIC = 15 ug/ml||Anti-Cryptococcus neofonnans IP 962-67, activity value is MIC = 15 ug/ml||Anti-Candida albicans IP 884-65, activity value is MIC = 15 ug/ml	skin, the arboreal frog, Giant leaf frog, Phyllomedusa bicolor, South America|||skin, the arboreal frog, Giant leaf frog, Phyllomedusa bicolor, South America|||Phyllomedusa bicolor [Two-colored leaf frog]|||Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)|||Phyllomedusa bicolor [Two-colored leaf frog]|||skin, the arboreal frog, Giant leaf frog, Phyllomedusa bicolor, South America|||Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)	Helix||Alpha helix	In Document 1 (Eur. J. Biochem. 1994), various peptides of the dermaseptin family (including DS I, DS II-V, and adenoregulin/DS bII) showed no significant hemolytic activity. When tested on rabbit red blood cells, no hemolysis was observed even at the highest test concentration of 250 µg/ml.|||[Ref:8306981]Lack hemolytic activity against rabbit red blood cells|||No hemolytic activity (0% hemolysis at 200 μM)|||[Ref:8306981]Lack hemolytic activity against rabbit red blood cells	"Biochem Biophys Res Commun. 1993 Mar 31;191(3):983-90. doi: 10.1006/bbrc.1993.1314. PubMed.|||Amiche M, Ducancel F, Lajeunesse E, Boulain JC, Ménez A, Nicolas P. 1993
 Biochem Biophys Res Commun. 1993 Mar 31;191(3):983-90. doi: 10.1006/bbrc.1993.1314. PubMed.|||Comparative Study Biochem Biophys Res Commun
. 1993 Mar 31;191(3):983-90. doi: 10.1006/bbrc.1993.1314.|||8306981|||Eur J Biochem 1994, 219 (1-2):145-154.||Ref.8306981|||8306981||Ref.8306981|||8306981|||Biochem Biophys Res Commun. 1993 Mar 31;191(3):983-90. doi: 10.1006/bbrc.1993.1314.|||Ref.8306981|||Biochem Biophys Res Commun. 1993 Mar 31;191(3):983-90. doi: 10.1006/bbrc.1993.1314. PubMed."	33	L
FPDB00002	AP00026|||AP00026|||Lactotransferrin precursor|||LFcinB|||DRAMP02840	FKCRRWQWRMKKLGAPSITCVRRAF	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||anti-sepsis||Synergistic AMPs||Anticancer||Anti-E. coli IID-861, activity value is MIC = 2 uM||Anti-K. pneumoniae JCM1662T, activity value is MIC = 3 uM||Anti-P. aeruginosa IFO-3446, activity value is MIC = 3 uM||Anti-S. aureus JCM-2151 or MRSA, activity value is MIC = 2 uM||Anti-L. monocytogenes IDF-1 b, activity value is MIC = 0.3 uM||MRSA||Antibacterial||Anti-Streptomyces scabiei S58, activity value is IC50 = 1.222||Anti-Escherichia coli L361, activity value is MIC = 4 uM||Anti-Salmonella Salford, activity value is MIC = 4 uM||Anti-Escherichia coli O:9, activity value is MIC = 6 uM||Anti-Pseudomonas fluorescens, activity value is MIC = 10 uM||Anti-Listeria monocytogenes, activity value is MIC = 2 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Bacillus cereus, activity value is MIC = 6 uM||Anti-ctive against E. coli IID-861, activity value is MIC = 2 uM	cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine)	Beta||Beta strand (4 strands; 8 residues)	E.coli ( MIC = 12.5 ug/ml)	"J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.|||Bellamy W, Takase M, Wakabayashi H, Kawase K, Tomita M.1992
 J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol. 1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.|||1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol
. 1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.|||9521752 , 8980754|||35213576|||Ref.8980754|||1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012"	25	
FPDB00003	AP00028|||Aborycin|||DRAMP00205|||AP00028|||DRAMP00205|||Rp 71955	CLGIGSCNDFAGCGYAVVCFW	Antiviral||Anti-HIV||inhibited the HIV-1 aspartyl protease (IC50||35 ug/ml) a||Anti-S.aureus, activity value is MIC = 8 ug/ml||Anti-Methicillin-resistant S.aureus, activity value is MIC = 8 ug/ml||Anti-Methicillin-resistant S.epidermidis, activity value is MIC = 128 ug/ml||Anti-S.aureus Sau 29213, activity value is MIC = 8 ug/ml||Anti-S.aureus Sau 1862, activity value is MIC = 16 ug/ml||Anti-S.aureus Sau 669, activity value is MIC = 32 ug/ml||Anti-S.aureus Sau 991, activity value is MIC = 16 ug/ml||Anti-S.aureus 16339, activity value is MIC = 16 ug/ml||Anti-S.aureus 6917, activity value is MIC = 16 ug/ml||Anti-S.aureus 16162, activity value is MIC = 64 ug/ml||Anti-S.aureus 718306, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus 745524, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus GDQ6P012P, activity value is MIC = 64 ug/ml||Anti-E.faecalis ATCC 29212, activity value is MIC = 8 ug/ml||Anti-E.gallinarum 5F52C, activity value is MIC = 0.5 ug/ml||Anti-B. thuringiensis, activity value is MIC = 2 ug/ml||Anti-A. baumannii ATCC 19606, activity value is MIC = 128 ug/ml||Antimicrobial||Antiviral ; HIV-1	Streptomyces strains AA3891|||Streptomyces sp. SCSIO ZS0098|||Streptomyces sp. (strain SP9440) (Gram-positive bacteria)|||Streptomyces strains AA3891|||Streptomyces sp. (strain SP9440) (Gram-positive bacteria)|||Actinomycete Sp9440	Beta||Beta strand	No hemolysis information or data found in the reference(s) presented in this entry	J Antibiot (Tokyo). 1993 Nov;46(11):1756-7. 1993 Nov;46(11):1756-7. doi: 10.7164/antibiotics.46.1756.PubMed.|||30795576|||J Antibiot (Tokyo). 1993 Nov;46(11):1756-1757.Biochemistry. 1994 Jan 11;33(1):42-50.|||1993 Nov;46(11):1756-7. doi: 10.7164/antibiotics.46.1756.|||J Antibiot (Tokyo). 1993 Nov;46(11):1756-1757.Biochemistry. 1994 Jan 11;33(1):42-50.|||8286361	21	
FPDB00004	AP00058|||1649|||1653|||1657|||1661|||AP00058|||Maximin 1|||DRAMP01107|||Maximin 1|||AP00058|||AP00058|||DRAMP01107|||Maximin 1	GIGTKILGGVKTALKGALKELASTYAN	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Spermicidal||Anti-HIV||Hemolytic||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 19.5 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 19.5 ug/ml||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 19.5 ug/ml||Anti-B. megatherium, activity value is MIC = 19.5 ug/ml||Anti-K. pneumoniae, activity value is MIC = 9 ug/ml||Anti-B. dysenterium, activity value is MIC = 2.7 uM||Anti-C. albicans ATCC2002, activity value is MIC = 3 uM||activity value is IC50 = 15.3 ug/ml||activity value is IC50 = 24.3 ug/ml||activity value is IC50 = 20.5 ug/ml||activity value is IC50 = 35.4 ug/ml||Anti-Escherichia coli ATCC25922, activity value is MIC = 9 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 4.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 9 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 4.5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 19.5 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 9 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 19.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 19.5 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 19.5 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 2.7 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima	Helix	"No hemolytic activity (0% hemolysis at 100 µM)|||In Document 3 (Eur. J. Immunol. 2005), the specific hemolytic values of the maximin family and maximin H family antimicrobial peptides in the skin secretions of the large-webbed bell toad (Bombina maxima) are not explicitly mentioned.|||No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml.

Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells"	"Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.
 Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides
. 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed."	27	L
FPDB00005	AP00060|||1650|||1654|||1658|||1662|||AP00060|||Maximin 3|||DRAMP01109|||Maximin 3|||AP00060|||DRAMP01109|||AP00060|||DRAMP01109|||Maximin 3	GIGGKILSGLKTALKGAAKELASTYLH	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Spermicidal||Anti-HIV||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 0.9 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 3.1 ug/ml||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 1.5 ug/ml||Anti-B. megatherium, activity value is MIC = 0.9 ug/ml||Anti-B. dysenterium, activity value is MIC = 0.9 ug/ml||Anti-K. pneumoniae, activity value is MIC = 3.1 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 15 uM||activity value is IC50 = 11.4 ug/ml||activity value is IC50 = 25.2 ug/ml||activity value is IC50 = 28 ug/ml||activity value is IC50 = 18 ug/ml||Anti-and T24, activity value is IC50 = 11||Anti-Escherichia coli ATCC25922, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 2 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 4 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 0.9 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 3.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 1.5 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 0.9 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 0.9 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 15 ug/ml||Anti-HIV-1, activity value is IC50 = 11.4 ug/ml||activity value is EC50 = 1.5 ug/ml||Anti-Cancer cell lines: C8166, activity value is IC50 = 11.4 ug/ml||Anti-Molt-4, activity value is IC50 = 25.2 ug/ml||Anti-BIU-87, activity value is IC50 = 28 ug/ml||Anti-T24, activity value is IC50 = 18 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima	Helix	"No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml.

Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells|||human RBC: HC50 >250 ug/ml, less hemo.lytic. toxic to cell IC50 11.4 ug/ml, anti-HIV-1 EC50 1.5 ug/ml, cell selectivity index 7.6 (Lai R et al., 2012)."	"Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.
 Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides
. 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed."	27	L
FPDB00006	AP00061|||AP00061|||Maximin 4|||DRAMP01110|||Maximin 4|||AP00061|||DRAMP01110|||AP00061|||DRAMP01110|||Maximin 4	GIGGVLLSAGKAALKGLAKVLAEKYAN	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Spermicidal||Anti-HIV||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 2.7 uM||Anti-S. aureus ATCC2592, activity value is MIC = 2.7 uM||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 2.7 uM||Anti-B. megatherium, activity value is MIC = 1.5 uM||Anti-B. dysenterium, activity value is MIC = 2.7 uM||Anti-K. pneumoniae, activity value is MIC = 15 uM||Anti-C. albicans ATCC2002, activity value is MIC = 15 uM||Anti-and P.uticale IFFI2001 . active against cancer cells C8166 and Molt-4, activity value is IC50 = 24||Anti-Escherichia coli ATCC25922, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 10 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 20 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.7 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 15 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 2.7 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 2.7 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 1.5 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 2.7 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 15 ug/ml||Anti-HIV-1, activity value is IC50 = 24.2 ug/ml||activity value is EC50 = 21.9 ug/ml||Anti-Cancer cell lines: C8166, activity value is IC50 = 24.2 ug/ml||Anti-Molt-4, activity value is IC50 = 35.4 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima	Helix	"No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml.

Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells|||toxic to cell IC50 24.2 ug/ml, similar to EC50 against HIV-1 (Lai R et al., 2012)."	"Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.
 Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides
. 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.  Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed."	27	
FPDB00007	AP00062|||1652|||1656|||1660|||1664|||AP00062|||Maximin 5|||DRAMP01111|||Maximin 5|||AP00062|||DRAMP01111|||AP00062|||DRAMP01111|||Maximin 5	SIGAKILGGVKTFFKGALKELASTYLQ	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anticancer||Anti-S. aureus ATCC2592, activity value is MIC = 3.6 uM||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 7.2 uM||Anti-B. megatherium, activity value is MIC = 12 uM||Anti-B. dysenterium, activity value is MIC = 12 uM||Anti-K. pneumoniae, activity value is MIC = 3.6 uM||Anti-C. albicans ATCC2002, activity value is MIC = 1.2 uM||Anti-A. flavus IFFI4015, activity value is MIC = 12 ug/ml||Anti-and P. uticale IFFI2001, activity value is MIC = 12 ug/ml||activity value is IC50 = 34.4 ug/ml||activity value is IC50 > 50 ug/ml||IC50 =>50 ug/ml||IC50=>50 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 3.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB10104, activity value is MIC = 7.2 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 12 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 12 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 3.6 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 1.2 ug/ml||Anti-Aspergillus flavus IFFI4015, activity value is MIC = 12 ug/ml||Anti-Penicillium uticale IFFI2001, activity value is MIC = 12 ug/ml||Anti-HIV-1, activity value is MIC = 34.4 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 3.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 7.2 ug/ml||Anti-Aspergillus flavus IFFI 4015, activity value is MIC = 12 ug/ml||Anti-Penicillium uticale IFFI 2001, activity value is MIC = 12 ug/ml||Anti-HIV-1, activity value is IC50 = 34.4 ug/ml||activity value is EC50 = 39.8 ug/ml||Anti-Cancer cell lines: C8166, activity value is IC50 = 34.4 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml.

Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells|||IC50 34.4 ug/ml, against HIV-1 cell selectivity index 0.88 (Lai R et al., 2012). Updated 2/2012; 12/2015; 11/2024 GW."	"Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.
 Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides
. 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed."	27	L
FPDB00008	AP00121|||DRAMP30312|||AP00121|||DRAMP30312	GLMDTVKNVAKNLAGHMLDKLKCKITGC	"Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-S. aureus, activity value is MIC = 50 uM||Anti-E. coli, activity value is MIC = 13 uM||Anti-and C. albicans, activity value is MIC = 67 uM||Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(90% inhibition at 500 uM);
Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(99% inhibition at 50 uM)."	North American frog, Rana pipiens , or Lithobates pipiens, ALSO: the Oregon spotted frog Rana pretiosa|||Rana pipiens (Northern leopard frog)|||North American frog, Rana pipiens , or Lithobates pipiens, ALSO: the Oregon spotted frog Rana pretiosa|||Rana pipiens (Northern leopard frog)	N/A	N/A	"Eur J Biochem. 2000 Feb;267(3):894-900. PubMed|||Eur J Biochem. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Comparative Study Eur J Biochem
. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Ref.11601906|||2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Virology. 2001 Sep 30;288(2):351-7.||Ref.11601906|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed."	28	
FPDB00009	AP00139|||1317|||1318|||1319|||1320|||1329|||1330|||1331|||1332|||1341|||1342|||1343|||1344|||AP00139|||Cecropin-A|||DRAMP03510	KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK	Anti-Gram+ & Gram-||Antiviral||Antiparasitic||Anti-HIV||Anticancer||Active against insect pathogens S. marcescens||P. aeruginosa||X. nematophilus||E. coli K12||and B. megaterium||no inhibition: B.subtilis (inhibition zone assays). ActivityG: D=L.||activity value is IC50 = 251.47 ug/ml||activity value is IC50 = 231.26 ug/ml||activity value is IC50 = 185.39 ug/ml||activity value is IC50 = 212.07 ug/ml||activity value is IC50 = 69.2 ug/ml||activity value is IC50 = 96.22 ug/ml||activity value is IC50 = 28.74 ug/ml||activity value is IC50 = 99.01 ug/ml||activity value is IC50 = 373.3||activity value is IC50 = 289.3 ug/ml||activity value is IC50 = 200.7 ug/ml||activity value is IC50 = 319.2 ug/ml||Antibacterial||Anti-Xenorhabdus nematophilus Xn21 . Gram-negative bacterium:Escherichia coli CVCC 245, activity value is MIC = 4.2||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 198||Anti-L. mono. CVCC 1599, activity value is MIC = 64.5	jiant silk moth, Hyalophora cecropia|||jiant silk moth, Hyalophora cecropia|||Hyalophora cecropia [Cecropia moth]|||Hyalophora cecropia	Helix||Alpha-helix	"Strong hemolytic activity (100% hemolysis at 10 μM)|||Hemolytic activity of Cecropin A: No significant hemolytic effect on Chang liver cells was observed at concentrations up to 20 µM. 
Hemolytic activity of Melittin: It exhibits high hemolytic activity against both E. coli and Chang liver cells, and at a concentration of 20 µM, the hemolytic effect on Chang liver cells is significant.|||Sheep RBC (HC50 = 169 ± 15.1 ug/ml)|||[Ref.29925795] 50% hemolysis at 169 ± 8.2 ug/ml against sheep red blood cells.|||Astragaloside A has no hemolytic effect on Chang liver cells even at concentrations up to 20 μM, whereas melittin exhibits high hemolytic activity against bacteria and Chang liver cells at low concentrations."	"Nature. 1981 Jul 16;292(5820):246-8. PubMed|||Steiner H, Hultmark D, Engström A, Bennich H, Boman HG1981
 Nature. 1981 Jul 16;292(5820):246-8. PubMed.|||Nature. 1981 Jul 16;292(5820):246-8. doi: 10.1038/292246a0.|||Nature
. 1981 Jul 16;292(5820):246-8. doi: 10.1038/292246a0.|||7140755, 27367675|||Ref.7140755||Ref.29925795|||1981 Jul 16;292(5820):246-8. doi: 10.1038/292246a0."	37	L
FPDB00010	AP00146|||1841|||1993|||2145|||2297|||2450|||2593|||2736|||3337|||3338|||3339|||3340|||3791|||3797|||3803|||3809|||3815|||AP00146|||Melittin|||DRAMP03002|||AP00146|||Melittin	GIGAVLKVLTTGLPALISWIKRKRQQ	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Insecticidal||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Anti-E. coli W 160-37, activity value is MIC = 5||Anti-S. aureus 8530B, activity value is MIC = 10||Anti-B. subtilis, activity value is MIC = 2||Anti-and P. putida NCIM 2102, activity value is MIC = 25||Anti-and E. agglomerans Bo-1S . ActivityG: D=L. Also active against colistin-resistant A. baumannii. C. albicans, activity value is MIC = 3||Anti-HSV-2 . It is also insecticidal, activity value is EC50 = 5.9||Anti-S. aureus, activity value is MIC = 4.4 uM||Anti-and E. faecium, activity value is MIC = 2.2 uM||Anti-P. aeruginosa, activity value is MIC = 2.2 uM||Anti-and V. vulnificus, activity value is MIC = 4.4 uM||Anti-T. beigelii, activity value is MIC = 4.4 uM||Anti-M. furfur, activity value is MIC = 8.8 uM||activity value is LD50 = 9 ug/ml||activity value is LD50 = 23 ug/ml||activity value is LD50 = 18 ug/ml||activity value is LD50 = 25 ug/ml||activity value is LD50 = 13 ug/ml||activity value is LD50 = 35 ug/ml||activity value is IC50 = 3.2||activity value is IC50 = 2.1||activity value is IC50 = 1.8||activity value is IC50 = 1.4||Anti-and E. agglomerans Bo-1S . ActivityG: D=L. Also active against colistin-resistant A. baumannii. Active against Gram+ bacteria S. mutants, activity value is MIC = 1.1 uM||Anti-S. aureus 29213 or 25923, activity value is MIC = 2 uM||Anti-L.rhamnosus 1.0385 or 1.0911, activity value is MIC > 128 uM||Anti-L.plantarum 7469, activity value is MIC > 128 uM||Anti-S.thermophilus YM-C, activity value is MIC > 128 uM||Anti-C. tropicalis cgmcc 2.1975, activity value is MIC = 2 uM||Anti-and C. parapsilosis cgmcc 2.3989, activity value is MIC = 2 uM||Anti-SARS CoV2, activity value is EC50 = 0.656 ug||Anti-E. coli 25922, activity value is MIC = 1 uM||Anti-E. coli UB1005, activity value is MIC = 1 uM||Anti-E. coli K88, activity value is MIC = 1 uM||Anti-E. coli K99, activity value is MIC = 1 uM||Anti-E. coli 078, activity value is MIC = 2 uM||Anti-E. coli 987P, activity value is MIC = 1 uM||Anti-P. aeruginosa 27853, activity value is MIC = 2 uM||Anti-P. aeruginosa PAO1, activity value is MIC = 2 uM||Anti-S. typhimurium 14028, activity value is MIC = 2 uM||Anti-S. typhimurium 7731, activity value is MIC = 2 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 2 uM||Anti-Listeria monocytogenes CMCC 54004, activity value is MIC = 1 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 uM||Anti-Escherichia coli UB 1005, activity value is MIC = 2 uM||Anti-Salmonella pullorum C7913, activity value is MIC = 8 uM||Anti-Salmonella enterica subsp enterica CMCC 50071, activity value is MIC = 2 uM||Enzyme inhibitor	Honeybee venom, Apis mellifera (also A. florea, A. cerana)|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Honeybee venom, Apis mellifera (also A. florea, A. cerana)|||Apis mellifera [Honeybee]|||Apis mellifera (Honeybee)|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Apis mellifera [Honeybee]	Helix||Alpha helix	"Since these amphiphilic peptides may be membrane dis ruptive
(12), magainin 2 was assayed for hemolytic activityagainst human erythrocytes (Fig. 4B). Unlike mellitin, ahemolytic, amphiphilic 26-amino acid peptide from beevenom (12), magainin 2 was not hemolytic up to at least 0.00015 ug/ml in phosphate-buffered normal saline (Fig. 4B). Theabsence of hemolytic activity of magainin 2 is striking in thatit possesses a potential hydrophobic moment very similar tomellitin (12)|||Moderate hemolytic activity (50% hemolysis at 50 µM)|||Under physiological salt concentration, when melittin at concentrations up to 500 µg was incubated with 1×10⁹/ml human red blood cells at 37°C for 3 hours, no significant hemolytic activity was observed (<0.5%); however, in 10,000 µM sodium phosphate buffer containing 340,000 µM sucrose, high concentrations of melittin exhibited significant hemolytic activity, although the exact values were not specified.|||​|||sheep red blood cells (11000 uM)|||In Document 11 (Gene 2018), the recombinant hybrid antimicrobial peptide AL32-P113 and the synthetic hybrid peptide L31-P113 both exhibited hemolytic activity against human erythrocytes. At a concentration of 500 μg/ml, the hemolysis rate of AL32-P113 was 10.4% ± 2.2%, and that of L31-P113 was 12.0% ± 0.7%; as controls, the hemolysis rate of LL-37 was 2.9% ± 0.7%, and that of Hst-5 was 1.6% ± 0.6%.|||Moderate hemolytic activity (50% hemolysis at 50 µM)|||sheep red blood cells (11000 uM)|||It is highly hemolytic (100% at 6.25 uM) and can cause histamine release (85% at 10 uM) (Kawakami et al., 2017)."	"Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med.|||Fennell JF, Shipman WH, Cole LJ.1967
 Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med.||ref AP252||Ref. AP83||ref, see AP2411||see ref. AP1480||Yasin et al., 2000||Perez-Cordero JJ et al. 2011 Peptides 32, 683-90|||Res Dev Tech Rep. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638|||. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638||Yasin et al., 2000|||Res Dev Tech Rep
. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||ref, see AP2411||see ref. AP1480||Yasin et al., 2000||Perez-Cordero JJ et al. 2011 Peptides 32, 683-90|||9568968, 35236909|||31199117|||Eur J Biochem. 1983 Sep 1;135(1):123-126.||Ref.29783753|||Res Dev Tech Rep. 1967 Dec 5:1-13.doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638|||9568968, 35236909|||Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med."	26	L
FPDB00011	AP00150|||1812|||1827|||1964|||1979|||2116|||2131|||2268|||2283|||2420|||2435|||2563|||2578|||2706|||2721|||AP00150|||Indolicidin|||DRAMP02857	ILPWKWPWWPWRR	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-MRSA||Hemolytic||Antibiofilm||Wound healing||Anticancer||Anti-S. aureus ATCC29213 or NCDC-0111 or MRSA, activity value is MIC = 1.5||Anti-L. monocytogenes ATCC-19111, activity value is MIC = 6 uM||Anti-B. cereus NCDC-0240, activity value is MIC = 0.8 uM||Anti-P. aeruginosa ATCC-27853 or NCDC-0105, activity value is MIC = 12.5||Anti-S. enterica serovar typhimurium ATCC-14028, activity value is MIC = 12.5 uM||Anti-E. coli MTCC-0723, activity value is MIC = 0.8 uM||Anti-and A. johnsonii NCDC-0072, activity value is MIC = 6 uM||activity value is LD50 = 64 ug/ml||activity value is LD50 = 12 ug/ml||activity value is LD50 = 345 ug/ml||activity value is LD50 = 30 ug/ml||activity value is LD50 = 200 ug||activity value is LD50 = 180 ug/ml||activity value is LD50 = 200 ug/ml||activity value is LD50 = 270 ug/ml||activity value is LD50 = 290 ug/ml||activity value is LD50 = 31 ug/ml||activity value is LD50 = 20 ug/ml||Anti-E. coli, activity value is MIC = 20 ug/ml||Anti-P. aeruginosa, activity value is MIC = 40 ug/ml||Anti-S. typhimurium, activity value is MIC = 20 ug/ml||Anti-B. subtilis, activity value is MIC = 10 ug/ml||Anti-S. epidermidis, activity value is MIC = 20 ug/ml||Anti-S. aureus, activity value is MIC = 5 ug/ml||Anti-K. pneumoniae strains NTUH-K2044, activity value is MIC = 32 ug/ml||Anti-ATCC 43816, activity value is MIC = 16 ug/ml||Anti-ATCC 13883, activity value is MIC = 32 ug/ml||Anti-ATCC 700603, activity value is MIC = 16 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	bovine neutrophils, cattle, Bos taurus|||bovine neutrophils, cattle, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine)|||bovine neutrophils, cattle, Bos taurus	Nonhelixbeta	"The document does not provide the half-hemolytic concentration (HC₅₀) of each peptide directly, but hemolytic activity is reflected through the percentage of hemolysis. The core data are as follows:

1. Hybrid Peptides (RN7-IN series)

RN7-IN10: At a concentration of 15.62 µg/ml, the hemolysis rate is 5.9%; no hemolytic activity is observed at its minimum inhibitory concentration (MIC = 7.81–15.62 µg/ml).
RN7-IN9, RN7-IN8, RN7-IN6: At a concentration of 15.62 µg/ml, the hemolysis rate is 0.0%; no hemolytic activity is observed at each respective MIC.
RN7-IN7: No hemolytic toxicity observed even at the highest tested concentration of 250 µg/ml (hemolysis rate 0.0%).

2. Indolicidin Analogs (IN series)

IN1: At a concentration of 250 µg/ml, the hemolysis rate is 3.6%; no hemolytic activity at its MIC (31.25–62.5 µg/ml).
IN2: At 250 µg/ml, hemolysis rate is 15.39%; no hemolytic activity at its MIC.
IN3: At 250 µg/ml, hemolysis rate is 2.39%; no hemolytic activity at its MIC (62.5 µg/ml).
IN4: Specific hemolysis data are not mentioned, but the document notes weak activity against Streptococcus pneumoniae (MIC = 250 µg/ml), suggesting low hemolysis risk at effective concentrations.

3. Parent Peptides

Indolicidin: At 20 µg/ml, hemolysis rate reaches 56.98%, showing the strongest hemolytic toxicity among all peptides.
Ranalexin: At 250 µg/ml, hemolysis rate is <15%, with hemolytic toxicity lower than Indolicidin.

The above data were measured by human red blood cell hemolysis experiments: a 4% human red blood cell suspension was incubated with peptides at 1.95–250 µg/ml at 37 °C for 1 hour, with PBS as a negative control (0% hemolysis) and 0.1% Triton X-100 as a positive control (100% hemolysis). Hemolysis rates were calculated based on absorbance at 560 nm. All peptides showed no cytotoxicity or hemolytic effects at their MIC values, and only some peptides exhibited slight hemolysis at concentrations far above their MICs.|||hRBC(50% hemolysis at 200 ug/ml)|||V- The 13 designed peptides exhibited no hemolysis or cytotoxicity at their minimum inhibitory concentrations (MIC). Among them, the hybrid peptides RN7-IN10, RN7-IN9, RN7-IN8, and RN7-IN6 showed hemolysis rates of 5.9%, 0.0%, 0.0%, and 0.0% at a concentration of 15.62 µg/ml, respectively; RN7-IN7 showed no hemolysis at a concentration of 250 µg/ml.

- Indolicidin exhibited a hemolysis rate of 56.98% at 20 µg/ml; Ranalexin exhibited a hemolysis rate of less than 15% at 250 µg/ml.

Indolicidin analogues IN1 and IN3 showed hemolysis rates of 3.6% and 2.39% at 250 µg/ml, respectively; IN2 showed a hemolysis rate of 15.39% at 250 µg/ml."	"J Biol Chem. 1992 Mar 5;267(7):4292-5. Pub-Med|||Selsted ME, Novotny MJ, Morris WL, Tang YQ, Smith W, Cullor JS.1992
J Biol Chem. 1992 Mar 5;267(7):4292-5. Pub-Med||Brahma B et al., 2015||Yasin et al., 2000|||J Biol Chem. 1992 Mar 5;267(7):4292-5.||Brahma B et al., 2015||Yasin et al., 2000|||J Biol Chem. 1992 Mar 5;267(7):4292-5. Pub-Med|||J Biol Chem
. 1992 Mar 5;267(7):4292-5.||Brahma B et al., 2015||Yasin et al., 2000|||1537821, 19191872, 35254120||Refer PubMed ID: 19191872||Refer PubMed ID: 35254120|||J Biol Chem. 1992 Mar 5;267(7):4292-4295.Biochemistry. 2000 Dec 26;39(51):15765-74.Life Sci. 2002 Jul 5;71(7):747-50.|||1992 Mar 5;267(7):4292-5.||Brahma B et al., 2015||Yasin et al., 2000"	13	L
FPDB00012	AP00157|||1708|||AP00157|||Dermaseptin-1|||DRAMP01668|||Dermaseptin-1|||AP00157|||DRAMP01668	ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||Anti-A. caviae IP67-16T, activity value is MIC = 0.5 uM||Anti-E. coli IP76-24, activity value is MIC = 1 uM||Anti-S. aureus IP76-25, activity value is MIC = 5 uM||Anti-N. brasiliensis IP118079, activity value is MIC = 35 uM||Anti-S. cerevisiae IP118079, activity value is MIC = 5 uM||Anti-IP886-65, activity value is MIC = 10 uM||Anti-C. neoformans IP960-67 and IP962-67, activity value is MIC = 0.5||Anti-M. canis IP1194, activity value is MIC = 15 uM||Anti-T. rubrum IP2043-92, activity value is MIC = 35 uM||Anti-T. metagrophytes IP877-71, activity value is MIC = 20 uM||Anti-mutant, activity value is MIC = 30 uM||Anti-A. simii J43, activity value is MIC = 15 uM||Anti-A. niger IP218-53 and A. fumigatus IP1025-70, activity value is MIC = 30 uM||Antibacterial||Anti-Microsporum canis, activity value is MIC = 50 ug/ml||Anti-Tricophyton rubrum, activity value is MIC = 100 ug/ml||Anti-Arthroderma simii, activity value is MIC = 100 ug/ml||Anti-Aspergillus fumigatus, activity value is MIC = 100 ug/ml||Anti-Aerornonas caviae IP T, activity value is MIC = 50 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 15 ug/ml||Anti-Candida albicans, activity value is MIC = 60 ug/ml||Anti-Escherichia coli, activity value is MIC = 5 ug/ml||Anti-Nocardia brasiliensis, activity value is MIC = 200 ug/ml||Anti-usporum canis IP 11 94, activity value is MIC = 50 ug/ml||Anti-Tricophyton rubrum IP 1400-82, activity value is MIC = 100 ug/ml||Anti-Arthroderma simii IP 1063-74, activity value is MIC = 100 ug/ml||Anti-Aspergillus fumigatus IP 1025-70, activity value is MIC = 100 ug/ml||Anti-Aerornonas caviae IP 67-16 T, activity value is MIC = 50 ug/ml||Anti-Escherichia coli IP 76-24, activity value is MIC = 5 ug/ml||Anti-Nocardia brasiliensis IP 16-80, activity value is MIC = 200 ug/ml||Anti-Cryptococcus neoformans IP 960-67, activity value is MIC = 15 ug/ml||Anti-Cryptococcus neofonnans IP 962-67, activity value is MIC = 15 ug/ml||Anti-Candida albicans IP 884-65, activity value is MIC = 60 ug/ml	Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagii [Sauvage leaf frog]|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Phyllomedusa sauvagii [Sauvage leaf frog]|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)	Helix||Alpha helix (CD)	No hemolytic activity (0% hemolysis at 200 μM)|||When incubated with rabbit red blood cells at 1000 µg/ml of dermaseptin for 20 minutes, 100% hemolysis was observed; however, no hemolysis was detected after 2 hours of incubation at a concentration of 200 µg/ml, and within the concentration range of 0.8–1000 µg/ml, there was no significant effect on normal clotting time (120 seconds).|||Dermaseptin in (Biochemistry 1991), at a concentration of 1000 µg/ml for 20 minutes, can cause 100% hemolysis, but at a concentration of 200 µg/ml for 2 hours, it has no hemolytic effect on rabbit red blood cells.|||No hemolytic activity (0% hemolysis at 200 μM)	"Biochemistry. 1991;30(36):8824-8830. doi:10.1021/bi00100a014.PubMed.|||Biochemistry. 1991;30(36):8824-8830. doi:10.1021/bi00100a014.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90|||J Biol Chem
. 1994 Dec 16;269(50):31635-41.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90|||9614066 , 1909573|||Biochemistry. 1991 Sep 10;30(36):8824-8830.|||1909573|||9614066 , 1909573|||Biochemistry. 1991;30(36):8824-8830. doi:10.1021/bi00100a014.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90|||1994 Dec 16;269(50):31635-41.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90"	34	L
FPDB00013	AP00160|||AP00160|||DS4|||DRAMP18708|||AP00160|||DRAMP18708	ALWMTLLKKVLKAAAKAALNAVLVGANA	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||anti-sepsis||Antimalarial||Hemolytic||Anti-A. caviae IP67-16T, activity value is MIC = 0.5 uM||Anti-E. coli IP76-24, activity value is MIC = 4 uM||Anti-S. aureus IP76-25, activity value is MIC = 10||Anti-N. brasiliensis IP118079, activity value is MIC = 10 uM||Anti-S. cerevisiae IP118079, activity value is MIC = 20 uM||Anti-IP886-65, activity value is MIC = 20 uM||Anti-C. neoformans IP960-67 and IP962-67, activity value is MIC = 1||Anti-M. canis IP1194, activity value is MIC = 15 uM||Anti-T. rubrum IP2043-92, activity value is MIC = 40 uM||Anti-T. metagrophytes IP877-71, activity value is MIC = 20 uM||Anti-mutant, activity value is MIC = 30 uM||Anti-A. simii J43, activity value is MIC = 20 uM||Anti-A. niger IP218-53 and A. fumigatus IP1025-70, activity value is MIC = 20||Anti-C. albicans, activity value is MIC = 11.5||Anti-S1, activity value is MIC = 295.97 ug/ml||Anti-S2, activity value is MIC = 380.82 ug/ml||Anti-S3, activity value is MIC = 343.68 ug/ml||Anti-S4, activity value is MIC = 358.13 ug/ml||Anti-S5, activity value is MIC = 274.17 ug/ml||Anti-S6, activity value is MIC = 330.65 ug/ml||Anti-S7, activity value is MIC = 411.06 ug/ml||Anti-S1, activity value is MIC = 250.22 ug/ml||Anti-S2, activity value is MIC = 269.06 ug/ml||Anti-S3, activity value is MIC = 490.77 ug/ml||Anti-S4, activity value is MIC = 257.4 ug/ml||Anti-S5, activity value is MIC = 308.89 ug/ml||Anti-S6, activity value is MIC = 344.32 ug/ml||Anti-S7, activity value is MIC = 275.73 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||[Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria||fungi||protozoa||and the enveloped herpes simplex virus type 1	Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa hypochondrialis [orange-legged leaf frog]|||Synthetic construct|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)	Helix||Alpha helix	No hemolytic activity (0% hemolysis at 200 μM)|||Dermaseptin S1: At a concentration of 70 µM, treatment for 1 hour did not cause hemolysis of human red blood cells. Dermaseptin S2: At 70 µM, hemolysis of red blood cells occurred within 1 hour. Dermaseptin S3: At 80 µM, hemolysis of red blood cells occurred within 1 hour. Dermaseptin S4: At 1 µM, 100% hemolysis occurred within 1 hour; at 0.5 µM, 50% hemolysis was observed. Dermaseptin S5: At a concentration of 90 µM, treatment for 1 hour did not cause hemolysis of human red blood cells.|||hRBCs, >50% hemolysis at 8 ug/ml|||hRBCs, >50% hemolysis at 128 ug/ml|||[Swiss_Prot Entry P80280]Strong hemolytic activity	"J Biol Chem. 1994;269(50):31635-31641.PubMed.|||J Biol Chem. 1994;269(50):31635-31641.|||1994 Dec 16;269(50):31635-41.|||J Biol Chem
. 1994 Dec 16;269(50):31635-41.|||33774792|||Eur. J. Biochem. 1994; 219:145-154.|||J Biol Chem. 1994;269(50):31635-31641.|||Eur. J. Biochem. 1994; 219:145-154."	28	
FPDB00014	AP00176|||AP00176|||Human defensin 1|||DRAMP03591|||AP00176|||DRAMP03591|||AP00176|||DRAMP03591	ACYCRIPACIAGERRYGTCIYQGRLWAFCC	Chemotactic||Anti-MRSA||Anti-toxin||Enzyme inhibitor||anti-sepsis||Wound healing||Anticancer||Anti-Killed C. difficile. Active against L. monocytogenes, activity value is MIC = 39.7 ug/ml||Anti-S.epidermis, activity value is MIC = 2.2 ug/ml||Anti-S. aureus or MRSA, activity value is MIC = 5.2||Anti-and S. maltophilia, activity value is MIC = 1.8||Anti-Gram+ & Gram-||Antiviral||Antifungal||Antiparasitic||Anti-HIV||T. cruzi||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)	neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens (Human)	Beta||Beta strand	Strong hemolytic activity (100% hemolysis at 5 μM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI1985
 J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||Comparative Study J Clin Invest
. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||17635867|||Viruses. 2021 Jun 26;13(7):1246.|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||Viruses. 2021 Jun 26;13(7):1246.Proteomics. 2009 Mar;9(5):1364-1373.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||Viruses. 2021 Jun 26;13(7):1246."	30	
FPDB00015	AP00177|||AP00177|||Human neutrophil peptide-2|||DRAMP03592|||AP00177|||DRAMP03592|||AP00177|||DRAMP03592	CYCRIPACIAGERRYGTCIYQGRLWAFCC	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Chemotactic||Anti-toxin||Enzyme inhibitor||Anticancer||Anti-P. aeruginosa CIP 76.110, activity value is MIC = 1 ug/ml||Anti-S. aureus ATCC 29213 and S. epidermidis CIP 68.21, activity value is MIC = 0.5 ug/ml||Anti-E. coli ATCC 8739 ( v, activity value is LD50 = 3.5||Anti-E. coli ATCC 25922 ( v, activity value is LD50 = 3.5||Anti-E. aerogenes ATCC 13048 ( v, activity value is LD50 = 16||Anti-S. aureus ATCC 25923 ( v, activity value is LD50 = 4.2||Anti-S. aureus ATCC 29213 ( v, activity value is LD50 = 2.4||Anti-B. cereus ATCC 10876 ( v, activity value is LD50 = 0.22||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)	neutrophils; natural killer cells, monocytes; sairway, aliva; Homo sapiens|||neutrophils; natural killer cells, monocytes; sairway, aliva; Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; sairway, aliva; Homo sapiens|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; sairway, aliva; Homo sapiens|||Homo sapiens (Human)	Beta||Beta strand	Strong hemolytic activity (100% hemolysis at 5 μM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI1985
 J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.|||Comparative Study J Clin Invest
. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.|||15616305|||Viruses. 2021 Jun 26;13(7):1246.|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.|||Viruses. 2021 Jun 26;13(7):1246.Proteomics. 2009 Mar;9(5):1364-1373.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.|||Viruses. 2021 Jun 26;13(7):1246."	29	
FPDB00016	AP00178|||AP00178|||HNP3|||DRAMP03593|||AP00178|||DRAMP03593|||AP00178|||DRAMP03593	DCYCRIPACIAGERRYGTCIYQGRLWAFCC	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Chemotactic||Anti-toxin||Enzyme inhibitor||Anticancer||Anti-P. aeruginosa CIP 76.110, activity value is MIC = 1 ug/ml||Anti-S. aureus ATCC 29213 and S. epidermidis CIP 68.21, activity value is MIC = 0.5 ug/ml||Anti-E. coli MG1655, activity value is MBC = 20 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)||Antiviral(SARS-CoV-3)	neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens (Human)	Beta||Beta strand	Strong hemolytic activity (100% hemolysis at 5 μM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI1985
 J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||Comparative Study J Clin Invest
. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||28423004|||Viruses. 2021 Jun 26;13(7):1246.|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||Viruses. 2021 Jun 26;13(7):1246.J Clin Invest. 1985 Oct;76(4):1436-1439.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||Viruses. 2021 Jun 26;13(7):1246."	30	
FPDB00017	AP00179|||DRAMP03594|||Neutrophil defensin 4|||AP00179|||DRAMP03594|||AP00179|||DRAMP03594	VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Active against E. coli||S. faecalis||and C. albicans.||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)||Antiviral(SARS-CoV-4)	Homo sapiens|||Homo sapiens (Human)|||Homo sapiens [Human]|||Homo sapiens|||Homo sapiens (Human)|||Homo sapiens|||Homo sapiens (Human)	Beta||Beta strand	No hemolysis information or data found in the reference(s) presented in this entry	"J. Biol. Chem. 1989; 264:11200-11203. PubMed.|||1989 Jul 5;264(19):11200-3.|||J. Biol. Chem. 1989; 264:11200-11203.|||Comparative Study J Biol Chem
. 1989 Jul 5;264(19):11200-3.|||Viruses. 2021 Jun 26;13(7):1246.|||2500436, 17088326, 30658057|||J. Biol. Chem. 1989; 264:11200-11203.|||Viruses. 2021 Jun 26;13(7):1246.Protein Sci. 2006 Dec;15(12):2749-2760.FEBS Lett. 2005 Jan 3;579(1):162-166.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.|||1989 Jul 5;264(19):11200-3.|||Viruses. 2021 Jun 26;13(7):1246."	33	
FPDB00018	AP00195|||1426|||AP00195|||IB-200|||IB-445|||OLAP-311|||Protegrin-1|||Recombinant Protegrin-1|||PG-1|||Protegrin|||IB-247	RGGRLCYCRRRFCVCVGR	"Anti-Gram+||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||anti-sepsis||Synergistic AMPs||Hemolytic||Antibiofilm||61% Cytotoxicity at 0.5 ug/ml||Anti-E. coli 004, activity value is MIC = 0.12 ug/ml||Anti-V, activity value is MIC = 0.25 ug/ml||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 0.5 ug/ml||Anti-S. aureus ATCC 33591 or MRSA, activity value is MIC = 2 ug/ml||Anti-MRSA, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 2 ug/ml||MIC E.Coli (ATCC 25922: 2 ug/ml||ATCC 700926: 0.25 ug/ml||MB 4902: 0.015 ug/ml)||K. pneumoniae (ATCC 13883: 0.5 ug/ml||ATCC 700603: 4 ug/ml||BAA 2146: 4 ug/ml)||A. baumannii (ATCC 19606): 0.25 ug/ml||P. aeruginosa (ATCC 27853): 4 ug/ml||B. subtilis (ATCC 6051): 0.03 ug/ml||S. aureus ATCC 43300 (MRSA): 4 ug/ml||C. albicans (ATCC 90028): 2 ug/ml||C. neoformans (ATCC 208821): 0.06 ug/ml||Anti-E. coli, activity value is MIC = 64 ug/ml||Anti-S. aureus, activity value is MIC = 64 ug/ml||Anti-S. epiderrnidis, activity value is MIC = 2 ug/ml||Anti-Escherichia coli ATCC 25377, activity value is MIC = 3 ug/ml||Anti-A. baumannii ATCC 238719, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 361823, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 371484, activity value is MIC = 2 ug/ml||Anti-A. baumannii ATCC 371981, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 378177, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 378648, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 379385, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 379622, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 380023, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 380667, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 381577, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 382933, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 383074, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 383290, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 386052, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 388538, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 5615, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 12316, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 12834, activity value is MIC = 4 ug/ml||Anti-S. aureus 29213, activity value is MIC = 1.7 ug/ml||Anti-E. coli 25922, activity value is MIC = 0.75 ug/ml||Anti-P. aeruginosa 27853, activity value is MIC = 0.5 ug/ml||Anti-E. faecalis 29212, activity value is MIC = 2.7 ug/ml||Anti-""A. baumannii ATCC 238719, activity value is MIC = 4 ug/ml||Antibacterial||Anti-K. pneumoniae strains NTUH-K2044, activity value is MIC = 0.5 ug/ml||Anti-ATCC 43816, activity value is MIC = 0.5 ug/ml||Anti-ATCC 13883, activity value is MIC = 0.5 ug/ml||Anti-ATCC 700603, activity value is MIC = 0.5 ug/ml||Anti-MKP103, activity value is MIC = 2 ug/ml||Anti-MKP103 wza mutant, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 0.5 ug/ml"	leukocytes; porcine neutrophil, pig, Sus scrofa|||eukocytes; porcine neutrophil, pig, Sus scrofa|||leukocytes; porcine neutrophil, pig, Sus scrofa|||Synthetic construct|||Porcine neutrophils|||Sus scrofa [pig]	Beta	96.1% hemolysis at 64 uM (see ref. AP05000).	Chem Pharm Bull (Tokyo). 1995 May;43(5):853-8|||Chem Pharm Bull (Tokyo). 1995 May;43(5):853-8||Blower et al., 2018||Yasin et al., 2000||Guo C et al., 2014||Sousa et al., 2017|||Blower et al., 2018||Yasin et al., 2000||Guo C et al., 2014||Sousa et al., 2017|||8647100|||31399625|||31214759|||28382709, 9257752, 31214759||Refer 31214759|||34502403|||35254120|||10931444	18	L
FPDB00019	AP00211|||AP00211|||OLAP-313|||Polyphemusin-1|||L-Polyphemusin|||DRAMP02933|||Polyphemusin-1|||AP00211	RRWCFRVCYRGFCYRKCR	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||anti-sepsis||Anti-Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1 ug/ml||Anti-E. coli K12, activity value is MIC = 6.3 ug/ml||Anti-S. Minnesota 1114W or R595, activity value is MIC = 3.1||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 6.3 ug/ml||Anti-and C. albicans M9, activity value is MIC = 6.3 ug/ml||MIC E.Coli (ATCC 25922: 0.5 ug/ml||ATCC 700926: 0.06 ug/ml||MB 4902: 0.03 ug/ml)||K. pneumoniae (ATCC 13883: 0.5 ug/ml||ATCC 700603: 1 ug/ml||BAA 2146: 2 ug/ml)||A. baumannii (ATCC 19606): 0.06 ug/ml||P. aeruginosa (ATCC 27853): 2 ug/ml||B. subtilis (ATCC 6051): 0.25 ug/ml||S. aureus ATCC 43300 (MRSA): 2 ug/ml||C. albicans (ATCC 90028): 1 ug/ml||C. neoformans (ATCC 208821): 0.06 ug/ml||Antibacterial||Anti-S.aureus, activity value is MIC = 16 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 0.5 ug/ml||Anti-E. coli DC2, activity value is MIC = 1 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 0.25 ug/ml||Anti-S. typhimurium, activity value is MIC = 1 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-Staphylococcus aureus SAP0017, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 1 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 1 ug/ml||Antifungal ; Candida albicans M9||Anti-Active against Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1 ug/ml	Limulus polyphemus|||Limulus polyphemus|||Limulus polyphemus [Atlantic horseshoe crab]|||Synthetic construct|||Limulus polyphemus (Atlantic horseshoe crab)|||Limulus polyphemus	Beta||No secondary structure (CD)	Moderate hemolytic activity (40% hemolysis at 20 μM)|||IC50 for hRBC = 1885 ug/ml	"J. Biochem. 1989; 106: 663-668. PubMed|||J. Biochem. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||J Biochem
. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||2514185|||28453851|||Biochim Biophys Acta. 2004 May 6;1698(2):239-250.|||2514185|||J. Biochem. 1989; 106: 663-668. doi: 10.1093/oxfordjournals.jbchem.a122913."	18	
FPDB00020	AP00212|||AP00212|||Polyphemusin-2|||DRAMP02935|||Polyphemusin-2|||AP00212|||DRAMP02935	RRWCFRVCYKGFCYRKCR	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1||Anti-E. coli K12, activity value is MIC = 12.5 ug/ml||Anti-S. Minnesota 1114W or R595, activity value is MIC = 3.1||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 6.3||Anti-and C. albicans M9, activity value is MIC = 6.3 ug/ml||Antibacterial||Antimicrobial||Antifungal ; Candida albicans M9||Anti-Active against Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1	Atlantic Limulus polyphemus|||Atlantic Limulus polyphemus|||Limulus polyphemus [Atlantic horseshoe crab]|||Limulus polyphemus (Atlantic horseshoe crab)|||Atlantic Limulus polyphemus|||Limulus polyphemus (Atlantic horseshoe crab)	Bridge	Moderate hemolytic activity (45% hemolysis at 20 μM)	"J. Biochem. 1989; 106: 663-668. PubMed|||J. Biochem. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||J Biochem
. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||2514185|||J Biochem. 1989 Oct;106(4):663-668.|||2514185|||J. Biochem. 1989; 106: 663-668. doi: 10.1093/oxfordjournals.jbchem.a122913.|||J Biochem. 1989 Oct;106(4):663-668.Biochim Biophys Acta. 2004 May 6;1698(2):239-250.|||1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913."	18	
FPDB00021	AP00214|||AP00214|||OLAP-314|||Tachyplesin-1|||TAC1_CARRO Tachyplesin-1|||TP I|||AP00214|||DRAMP02926	KWCFRVCYRGICYRRCR	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Anti-Gram- S. typhimurium LT2 or 1102, activity value is MIC = 0.8||Anti-E. coli K12, activity value is MIC = 1.6||Anti-S. Minnesota 1114W or R595, activity value is MIC = 1.6||Anti-P. aeruginosa, activity value is MIC = 12.5 ug/ml||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 3.1||Anti-B. subtilis, activity value is MIC = 3.1 ug/ml||Anti-C. albicans M9, activity value is MIC = 3.1 ug/ml||Anti-and C. neoformans IMF 40040, activity value is MIC = 1.56 ug/ml||MIC E.Coli (ATCC 25922: 0.06 ug/ml||ATCC 700926: 0.03 ug/ml||MB 4902: 0.016 ug/ml)||K. pneumoniae (ATCC 13883: 0.125 ug/ml||ATCC 700603: 0.25 ug/ml||BAA 2146: 0.25 ug/ml)||A. baumannii (ATCC 19606): 0.125 ug/ml||P. aeruginosa (ATCC 27853): 0.25 ug/ml||B. subtilis (ATCC 6051): 0.125 ug/ml||S. aureus ATCC 43300 (MRSA): 1 ug/ml||C. albicans (ATCC 90028): 4 ug/ml||C. neoformans (ATCC 208821): 0.125 ug/ml||Anti-28960954: E.coli ATCC25922, activity value is MIC = 0.06 ug/ml||Anti-K. pneumoniae ATCC13883, activity value is MIC = 0.06 ug/ml||Anti-A. baumannii ATCC 700603, activity value is MIC = 0.25 ug/ml||Anti-A. baumannii BAA, activity value is MIC = 0.25 ug/ml||Anti-PmxR, activity value is MIC = 2 ug/ml||Anti-A. baumannii ATCC19606, activity value is MIC = 0.06 ug/ml||Anti-PmxR, activity value is MIC = 0.125 ug/ml||Anti-P.aeuroginsa ATCC 27853, activity value is MIC = 0.125 ug/ml||Anti-P.aeuroginsa FADDI-FAO70, activity value is MIC = 0.25 ug/ml||Anti-B.subtilis ATCC6051, activity value is MIC = 0.06 ug/ml||Anti-S.aureus ATCC43300, activity value is MIC = 0.25 ug/ml||Anti-C.albicans ATCC90028, activity value is MIC = 2 ug/ml||Anti-C.neoformanas ATCC208821, activity value is MIC = 0.125 ug/ml||Anti-31455019 : Escherichia coli ATCC 25922, activity value is MIC = 0.5||Anti-Escherichia coli DC2 CGSC 7139, activity value is MIC = 0.0625||Anti-S. aureus ATCC 25923, activity value is MIC = 1||Anti-S. aureus ATCC 6538, activity value is MIC = 4||Anti-Escherichia coli ML-35p, activity value is MIC = 0.062 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 0.5 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 0.5 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 8 uM||Anti-Staphylococcus aureus 209P, activity value is MIC = 0.5 uM||Anti-B. subtilis B-886, activity value is MIC = 0.5 uM||Anti-M. luteus B-1314, activity value is MIC = 1 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	hemocytes, Southeast Asia, Tachypleus tridentatus; Tachypleus gigas; Carcinoscorpius rotundicauda|||hemocytes, Southeast Asia, Tachypleus tridentatus; Tachypleus gigas; Carcinoscorpius rotundicauda|||Tachypleus tridentatus|||Tachypleus gigas|||Carcinoscorpius rotundicauda|||Limulus polyphemus [Atlantic horseshoe crab]|||hemocytes, Southeast Asia, Tachypleus tridentatus; Tachypleus gigas; Carcinoscorpius rotundicauda|||Tachypleus tridentatus (Japanese horseshoe crab)	Beta||Beta strand	Weak hemolytic activity (15% hemolysis at 20 μM)|||hRBC (38% hemolysis at 100 uM)|||[Ref.29870123] 9.6% hemolytic activity at 8 ug/ml and 72.8% hemolytic activity at 512 ug/ml against human red blood cells.	"J Biol Chem. 1988 Nov 15;263(32):16709-13.PubMed.|||Nakamura T, Furunaka H, Miyata T, Tokunaga F, Muta T, Iwanaga S, Niwa M, Takao T, Shimonishi Y.1988
 J Biol Chem. 1988 Nov 15;263(32):16709-13.PubMed.||Peschel et al., 2001|||J Biol Chem. 1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||J Biol Chem
. 1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||3141410, 28960954, 31455019|||2229025|||30486233|||1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||Biochemistry 2002; 41: 12359.J Biochem. 1990 Aug;108(2):261-266.  Int J Mol Sci. 2019 Aug 26;20(17):4184."	17	
FPDB00022	AP00240|||AP00240|||Caerin-1.1|||Caerin 1.1|||Caerin|||DRAMP01549|||AP00240|||DRAMP01549|||Caerin-1.1	GLLSVLGSVAKHVLPHVVPVIAEHL	Anti-Gram+ & Gram-||Antiviral||Antiparasitic||Anti-HIV||Anti-MRSA||Antibiofilm||Anticancer||Anti-B. cereus, activity value is MIC = 50 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 1.5 uM||Anti-L. innocua, activity value is MIC = 25 ug/ml||Anti-M. luteus, activity value is MIC = 12 ug/ml||Anti-S. aureus ATCC 25923 or 29213, activity value is MIC = 3||Anti-S. epidermidis, activity value is MIC = 12 ug/ml||Anti-S. uberis, activity value is MIC = 12 ug/ml||Anti-E.clocae, activity value is MIC > 100 ug/ml||Anti-P. multocida, activity value is MIC = 12||Anti-and P. haemolytica, activity value is MIC = 25 ug/ml||Antibacterial||Anti-Bacillus cereus, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 1.5 ug/ml||Anti-Listeria innocua, activity value is MIC = 25 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Pasteurella haemolytica, activity value is MIC = 25 ug/ml||Anti-Pasteurella multocida, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 12 ug/ml||Anti-S.aureus, activity value is MIC = 18.75 uM||activity value is MBC = 125 uM||Anti-E.Coli, activity value is MIC = 115 uM||activity value is MBC = 250 uM||Antimicrobial||Anti-Gram+||Anti-Gram-||Anti-Micrococcus luteus, activity value is MIC = 12.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3||Anti-Staphylococcus epidermis, activity value is MIC = 12.5 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 12.5 ug/ml||Anti-GDM1.441, activity value is MIC = 15 ug/ml||Anti-GDM1.1263, activity value is MIC = 30 ug/ml||Anti-P. aeruginosa GDM1.443, activity value is MIC = 60 ug/ml||Anti-S. hemolyiicus GDM1.245, activity value is MIC = 15 ug/ml||Anti-MRSA1, activity value is MIC = 60 ug/ml||Anti-MRSA2, activity value is MIC = 15 ug/ml||Anti-MRSA3, activity value is MIC = 30 ug/ml	Australian green tree frog, Litoria splendida; Litoria rothii|||Australian green tree frog, Litoria splendida; Litoria rothii|||Litoria splendida [magnificent tree frog]|||Litoria gilleni [Centralian tree frog]|||Litoria rothii [Roth's tree frog]|||Uperoleia mjobergii [Australian toadlet]|||Litoria raniformis [Australian tree frog]|||Litoria splendida (Magnificent tree frog) (Litoria gilleni) (Litoria caerulea)|||Australian green tree frog, Litoria splendida; Litoria rothii|||Litoria splendida (Magnificent tree frog) (Litoria gilleni) (Litoria caerulea)|||Litoria splendida [magnificent tree frog]|||Litoria gilleni [Centralian tree frog]	Helix||Alpha helix	"No hemolytic activity (0% hemolysis at 100 µM)|||The hemolytic values of peptides related to the skin granular gland secretions of African clawed frog (Xenopus) in the document are as follows. The experiment measured the hemolysis rate by adding peptides at different concentrations to a 5% human red blood cell suspension and incubating at 37°C for 30 minutes (100% hemolysis was induced by 0.2% Triton X-100):

- At a peptide concentration of 0 μg/ml: Hemolysis rates for Magainin 2, PGLa, XPF, and bee venom peptide Mellitin were all 0%.
- At a peptide concentration of 50 μg/ml: Hemolysis rates were 4% for Magainin 2, 4% for PGLa, 1% for XPF, and 100% for bee venom peptide Mellitin.
- At a peptide concentration of 100 μg/ml: Hemolysis rates were 3% for Magainin 2, 3% for PGLa, 1% for XPF (bee venom peptide Mellitin was not tested).
- At a peptide concentration of 200 μg/ml: Hemolysis rates were 3% for Magainin 2, 4% for PGLa, 2% for XPF (bee venom peptide Mellitin was not tested).
- At a peptide concentration of 500 μg/ml: Hemolysis rates were 4% for Magainin 2, 5% for PGLa, 5% for XPF (bee venom peptide Mellitin was not tested).
- At a peptide concentration of 1000 μg/ml: Hemolysis rates were 6% for Magainin 2, 7% for PGLa, 6% for XPF (bee venom peptide Mellitin was not tested).

Among them, bee venom peptide Mellitin served as the positive control. Magainin 2, PGLa, and XPF, three antimicrobial peptides derived from Xenopus, showed extremely low hemolytic activity, with hemolysis rates still below 8% even at the high concentration of 1000 μg/ml.|||Bacillus cereus ( MIC = 50 ug/ml), Leuconostoc lactis ( MIC = 1.5 ug/ml), Listeria innocua ( MIC = 25 ug/ml) , Micrococcus luteus ( MIC = 12.5 ug/ml), Pasteurella multocida ( MIC = 25 ug/ml), Staphylococcus aureus ( MIC = 3-12 ug/ml), Staphylococcus epidermis ( MIC = 12.5 ug/ml), Streptococcus uberis ( MIC = 12.5 ug/ml); [Refer PubMed ID - 34259550: S. aureus, GDM1.441 (MIC= 15 ug/ml), MRSA, GDM1.1263 (MIC= 30 ug/ml), P. aeruginosa GDM1.443 (MIC= 60 ug/ml), S. hemolyiicus GDM1.245 (MIC= 15 ug/ml), MRSA1 (Clincial isolate) (MIC= 60 ug/ml), MRSA2 (Clincial isolate) (MIC= 15 ug/ml), MRSA3 (Clincial isolate) (MIC= 30 ug/ml)]|||No hemolysis information or data found in the reference(s) presented in this entry"	"Eur J Biochem 1997; 247 (2): 545-57|||Wong H, Bowie JH, Carver JA.1997, Australia
 Eur J Biochem 1997; 247 (2): 545-57||same ref as AP2008|||Eur J Biochem 1997; 247 (2): 545-57||same ref as AP2008|||Eur J Biochem 1997; 247 (2): 545-57|||same ref as AP2008|||10601876, 34259550|||10461748|||28478484|||[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ug/ml), Leuconostoc lactis (MIC=1.5 ug/ml), Listeria innocua (MIC=25 ug/ml), Micrococcus luteus (MIC=12.5 ug/ml), Staphylococcus aureus (MIC=3-12 ug/ml), Staphylococcus epidermis (MIC=12.5 ug/ml), Streptococcus uberis (MIC=12.5 ug/ml);
Gram-negative bacterium: Pasteurella multocida (MIC=25 ug/ml).
[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=7.8 uM);inhibition of HIV transfer by dendritic cells to T cells(IC50=12.6 uM)|||Eur J Biochem 1997; 247 (2): 545-57||same ref as AP2008|||J Virol. 2005 Sep;79(18):11598-606.Eur J Biochem. 1997 Jul 15;247(2):545-557.Eur J Biochem. 2003 May;270(9):2068-2081.Peptides. 2004 Jun;25(6):1035-1054.|||10601876, 34259550"	25	
FPDB00023	AP00241|||AP00241|||Caerin-1.2|||DRAMP01551|||AP00241|||DRAMP01551	GLLGVLGSVAKHVLPHVVPVIAEHL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Antibacterial||Antimicrobial	Australian frog Litoria caerula|||Australian frog Litoria caerula|||Litoria caerulea [Green tree frog]|||Litoria caerulea (Australian frog)|||Australian frog Litoria caerula|||Litoria caerulea (Australian frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J. Chem. Res. 1993; 138: 910-936. PubMed.|||J. Chem. Res. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Peptides. 2015 Sep;71:296-303.J. Chem. Res. 1993; 138: 910-936.|||1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Peptides. 2015 Sep;71:296-303.J. Chem. Res. 1993; 138: 910-936."	25	
FPDB00024	AP00242|||AP00242|||Caerin-1.3|||DRAMP01552	GLLSVLGSVAQHVLPHVVPVIAEHL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anticancer||Anti-B. cereus, activity value is MIC = 50 ug/ml||Anti-E. coli, activity value is MIC = 100 ug/ml||Anti-L. lactis, activity value is MIC = 25 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 1.5 ug/ml||Anti-P. multocida, activity value is MIC = 25 ug/ml||Anti-S. aureus, activity value is MIC = 100 ug/ml||Anti-S. epidermidis, activity value is MIC = 100 ug/ml||Anti-and S. uberis, activity value is MIC = 100 ug/ml||Antibacterial	Australian frog Litoria caerula|||Australian frog Litoria caerula|||Litoria caerulea [Green tree frog]|||Litoria caerulea (Australian frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"J. Chem. Res. 1993; 138: 910-936. PubMed.|||Stone DJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ.1993, Australia
 J. Chem. Res. 1993; 138: 910-936. PubMed.||VanCompernolle et al., 2015|||J. Chem. Res. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.||VanCompernolle et al., 2015|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.||VanCompernolle et al., 2015|||Gram-positive bacteria: Bacillus cereus (MIC=50 ug/ml), Leuconostoc lactis (MIC=3 ug/ml), Listeria innocua (MIC=50 ug/ml), Micrococcus luteus (MIC=25 ug/ml), Staphylococcus aureus (MIC=6-12 ug/ml), Staphylococcus epidermis (MIC=12 ug/ml), Streptococcus uberis (MIC=25 ug/ml);
Gram-negative bacterium: Pasteurella multocida (MIC=50 ug/ml). (Ref.2)|||1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.||VanCompernolle et al., 2015"	25	
FPDB00025	AP00243|||AP00243|||Caerin-1.4|||DRAMP01553	GLLSSLSSVAKHVLPHVVPVIAEHL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Antibacterial	Australian frog Litoria caerula|||Australian frog Litoria caerula|||Litoria gilleni [Centralian tree frog]|||Litoria caerulea [Green tree frog]|||Litoria caerulea (Green tree frog) (also Litoria gilleni) (Centralian tree frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"J. Chem. Res. 1993; 138: 910-936. PubMed.|||J. Chem. Res. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Gram-positive bacteria: Bacillus cereus (MIC=50 ug/ml), Leuconostoc lactis (MIC=12 ug/ml), Listeria innocua (MIC=100 ug/ml), Micrococcus luteus (MIC=0.4 ug/ml), Staphylococcus aureus (MIC=100 ug/ml), Staphylococcus epidermis (MIC=25 ug/ml), Streptococcus uberis (MIC=100 ug/ml);
Gram-negative bacteria: Escherichia coli (MIC=50 ug/ml), Pasteurella multocida (MIC=25 ug/ml). (Ref.2)|||1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x."	25	
FPDB00026	AP00244|||AP00244|||Caerin-1.5|||DRAMP01555|||AP00244|||DRAMP01555	GLLSVLGSVVKHVIPHVVPVIAEHL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anticancer||Anti-L. lactis, activity value is MIC = 3 ug/ml||Anti-M. luteus, activity value is MIC = 12 ug/ml||Anti-S. epidermidis, activity value is MIC = 25 ug/ml||Anti-L. innocua and S. uberis, activity value is MIC = 50 ug/ml||Antibacterial||Anti-Bacillus cereus, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Pasteuretla multocida, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 25 ug/ml||Anti-S.aureus ATCC 29213, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 25 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml||Antimicrobial||Anti-Gram+||Anti-Gram-	Australian frog Litoria caerula|||Australian frog Litoria caerula|||Litoria caerulea [Green tree frog]|||Litoria caerulea|||Litoria caerulea (Green tree frog)|||Australian frog Litoria caerula|||Litoria caerulea (Green tree frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J. Chem. Res. 1993; 138: 910-936. PubMed.|||Stone DJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ.1993, Australia
 J. Chem. Res. 1993; 138: 910-936. PubMed.||VanCompernolle et al., 2015|||J. Chem. Res. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||15203252|||[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ug/ml), Leuconostoc lactis (MIC=3 ug/ml), Listeria innocua (MIC=50 ug/ml), Micrococcus luteus (MIC=12 ug/ml), Staphylococcus aureus (MIC=25 ug/ml), Staphylococcus epidermis (MIC=25 ug/ml), Streptococcus uberis (MIC=50 ug/ml);
Gram-negative bacterium: Pasteurella multocida (MIC=25 ug/ml).
[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=3 uM).|||1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Peptides. 2015 Sep;71:296-303.Peptides. 2004 Jun;25(6):1035-1054.J. Chem. Res. 1993; 138: 910-936."	25	
FPDB00027	AP00245|||AP00245|||Caerin-1.6|||Caerin 1.6|||Caerin-1.16|||DRAMP01556|||AP00245|||DRAMP01556	GLFSVLGAVAKHVLPHVVPVIAEKL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anticancer||Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 3 uM||Anti-L. innocua, activity value is MIC = 50 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-S. aureus ATCC 25923 or 29213, activity value is MIC = 6||Anti-S. epidermidis, activity value is MIC = 12.5 ug/ml||Anti-S. uberis, activity value is MIC = 25 ug/ml||Anti-E.clocae, activity value is MIC > 100 ug/ml||Anti-P. multocida, activity value is MIC = 25 ug/ml||Anti-and P. haemolytica, activity value is MIC = 50 ug/ml||Antibacterial||Antimicrobial	skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||Litoria xanthomera [Orange-thighed frog]|||Litoria splendida [magnificent tree frog]|||Litoria rothii [Roth's tree frog]|||Litoria xanthomera (Orange-thighed frog) (Litoria chloris)|||skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||Litoria xanthomera (Orange-thighed frog) (Litoria chloris)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||Escherichia coli ( MIC = 50 ug/ml), Leuconostoc lactis ( MIC = 3 ug/ml), Listeria innocua ( MIC = 50 ug/ml) , Micrococcus luteus ( MIC = 25 ug/ml), Pasteurella multocida ( MIC = 25 ug/ml), Staphylococcus aureus ( MIC = 6 ug/ml), Staphylococcus epidermis ( MIC = 12 ug/ml), Streptococcus uberis ( MIC = 25 ug/ml)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Pept Sci. 1997 May-Jun;3(3):181-5. PubMed.|||Steinborner ST, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ, Ramsay SL.1997, Australia
 J Pept Sci. 1997 May-Jun;3(3):181-5. PubMed.||same ref as AP2008||VanCompernolle et al., 2015|||J Pept Sci. 1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.||same ref as AP2008||VanCompernolle et al., 2015|||J Pept Sci
. 1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.||same ref as AP2008||VanCompernolle et al., 2015|||9230483|||10601876|||16124032, 19539637|||Peptides. 2015 Sep;71:296-303.J Pept Sci. 1997 May-Jun;3(3):181-185.Rapid Commun Mass Spectrom. 1997;11(9):997-1000.J Pept Res. 1998 Feb;51(2):121-126.|||1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.||same ref as AP2008||VanCompernolle et al., 2015|||J Pept Sci. 1997 May-Jun;3(3):181-185.Rapid Commun Mass Spectrom. 1997;11(9):997-1000.J Pept Res. 1998 Feb;51(2):121-126."	25	
FPDB00028	AP00246|||AP00246|||Caerin-1.7|||DRAMP01557|||AP00246|||DRAMP01557	" 
GLFKVLGSVAKHLLPHVAPVIAEKL"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anticancer||Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 3 uM||Anti-L. innocua, activity value is MIC = 50 ug/ml||Anti-M. luteus, activity value is MIC = 12.5 ug/ml||Anti-S. aureus ATCC 25923 or 29213, activity value is MIC = 12.5||Anti-S. epidermidis, activity value is MIC = 50 ug/ml||Anti-and S. uberis, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Pasteuretla multocida, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12||Anti-S.aureus ATCC 29123, activity value is MIC = 12||Anti-Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml||Antimicrobial||Antibacterial	skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||Litoria xanthomera|||Litoria xanthomera (Orange-thighed frog) (Litoria chloris)|||skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||Litoria xanthomera (Orange-thighed frog) (Litoria chloris)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Pept Sci. 1997 May-Jun;3(3):181-5. PubMed.|||Steinborner ST, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ, Ramsay SL.1997, Australia
 J Pept Sci. 1997 May-Jun;3(3):181-5. PubMed.|||J Pept Sci. 1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.|||J Pept Sci
. 1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.||VanCompernolle et al., 2015|||15203252|||Peptides. 2015 Sep;71:296-303.J Pept Sci. 1997 May-Jun;3(3):181-185.Rapid Commun Mass Spectrom. 1997;11(9):997-1000.J Pept Res. 1998 Feb;51(2):121-126.|||1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.|||Peptides. 2015 Sep;71:296-303.J Pept Sci. 1997 May-Jun;3(3):181-185.Rapid Commun Mass Spectrom. 1997;11(9):997-1000.J Pept Res. 1998 Feb;51(2):121-126."	25	
FPDB00029	AP00248	" 
GLFGVLGSIAKHVLPHVVPVIAEK"	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-MRSA||Antibiofilm||Anticancer||Anti-M. luteus, activity value is MIC = 12 ug/ml||Anti-S. aureus or MRSA, activity value is MIC = 12 ug/ml||Anti-L. innocua, activity value is MIC = 25 ug/ml||Anti-S. epidermidis, activity value is MIC = 25 ug/ml||Anti-S. uberis, activity value is MIC = 25 ug/ml||Enzyme inhibitor	Blue-thighed frog, Litoria chloris, Australia|||Litoria chloris, Australia	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"J. Pept. Res.1998; 51: 121-126. PubMed.|||Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ.1998, Australia
 J. Pept. Res.1998; 51: 121-126. PubMed.|||J. Pept. Res.1998; 51: 121-126. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||J. Pept. Res.1998; 51: 121-126. PubMed.|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x."	24	
FPDB00030	AP00257|||AP00257|||Caerin-4.1|||AP00257|||DRAMP01574	" 
GLWQKIKSAAGDLASGIVEGIKS"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-M. luteus, activity value is MIC = 12 ug/ml||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	Green tree frog Litoria caerula, Australia|||Green tree frog Litoria caerula, Australia|||Litoria caerulea [Green tree frog]|||Green tree frog Litoria caerula, Australia|||Litoria caerulea (Green tree frog)	Helix	No hemolysis information or data found in the reference(s) presented in this entry	J. Chem. Res. 1993; 138: 910-936. PubMed.|||J. Chem. Res. 1993; 138: 910-936|||J. Chem. Res. 1993; 138: 910-936|||Peptides. 2004 Jun;25(6):1035-1054.J. Chem. Res. 1993; 138: 910-936.	23	
FPDB00031	AP00260|||AP00260|||Maculatin-1.1|||Maculatin 1.1|||Mac1-NH2|||Mac1-OH|||DRAMP01364|||AP00260|||DRAMP01364|||AP00260|||DRAMP01364	" 
GLFGVLAKVAAHVVPAIAEHF"	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anticancer||Anti-B. cereus, activity value is MIC = 50 ug/ml||Anti-L. lactis, activity value is MIC = 3 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 12 ug/ml||Anti-P. multocida, activity value is MIC = 50 ug/ml||Anti-S. aureus, activity value is MIC = 6||Anti-S. uberis, activity value is MIC = 3 ug/ml||Anti-S. epidermidis, activity value is MIC = 12 ug/ml||Anti-S. faecalis, activity value is MIC = 25 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Antibacterial||Anti-S.aureus, activity value is MIC = 8 uM||activity value is MBC = 37.5 uM||Anti-E.Coli, activity value is MIC = 110 uM||activity value is MBC = 125 uM||Anti-S. aureus ATCC29213, activity value is MIC = 5.4||Anti-E. coli ATCC25922, activity value is MIC = 7.7||Anti-S. aureus ATCC29213, activity value is MIC = 94.2||Anti-E. coli ATCC25922, activity value is MIC = 26.6||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Bacillus cereus, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 6 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 3 ug/ml||Anti-Pasteurella multocida, activity value is MIC = 50 ug/ml||Antimicrobial||Anti-Gram+||Anti-Gram-	skin secretions, Litoria genimaculate, Litoria eucnemis, Australia|||skin secretions, Litoria genimaculate, Litoria eucnemis, Australia|||Litoria genimaculata [Green-eyed tree frog]|||Litoria raniformis [Australian tree frog]|||Litoria genimaculata (Green-eyed tree frog)|||skin secretions, Litoria genimaculate, Litoria eucnemis, Australia|||Litoria genimaculata (Green-eyed tree frog)|||skin secretions, Litoria genimaculate, Litoria eucnemis, Australia|||Litoria genimaculata (Green-eyed tree frog)	Helix||Alpha helix	No hemolysis information or data found in the reference(s) presented in this entry	"J. Pept. Sci. 1998; 4: 111-115. PubMed.|||Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.1998, Australia
 J. Pept. Sci. 1998; 4: 111-115. PubMed.|||J. Pept. Sci. 1998; 4: 111-115. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||Comparative Study J Pept Sci
. 1998 Apr;4(2):111-5. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||9620615|||28478484|||33891157|||J Virol. 2005 Sep;79(18):11598-606.||Ref.15203252||Ref.161407|||16140737||Ref.15203252||Ref.16140737|||J. Pept. Sci. 1998; 4: 111-115. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||Ref.15203252||Ref.16140737|||1998 Apr;4(2):111-5. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||J Virol. 2005 Sep;79(18):11598-606.J Pept Sci. 1998 Apr;4(2):111-115.Peptides. 2004; 25: 1035-1054."	21	
FPDB00032	AP00274|||AP00274|||Circulin-A|||DRAMP00877|||DRAMP00878|||Circulin-A|||AP00274|||DRAMP00877|||AP00274|||DRAMP00877	GIPCGESCVWIPCISAALGCSCKNKVCYRN	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-Gram- E.coli, activity value is MIC > 500 uM||Anti-P.aeruginosa, activity value is MIC > 500 uM||Anti-P. vulgaris, activity value is MIC = 54.6 uM||Anti-K.oxytoca, activity value is MIC > 500 uM||Anti-S. aureus, activity value is MIC = 0.19 uM||Anti-M.luteus, activity value is MIC > 500 uM||Anti-C.albicans, activity value is MIC > 500 uM||Anti-C. kefyr, activity value is MIC = 18.6 uM||Anti-and C. tropicalis, activity value is MIC = 19.4 uM||Anti-Proteus.vulgaris, activity value is MIC = 54.6 uM||Anti-C. tropicalis, activity value is MIC = 19.4 uM||Anti-Staphylococcus aureus, activity value is MIC = 0.19 uM||Anti-Staphylococcus aureus, activity value is MIC = 13.5 uM||Anti-15.6). Fungi : Candida kefyr, activity value is MIC = 29 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	Chassalia parviflora	Combine Helix and Beta structure||Alpha helix (1 helices; 4 residues)||Beta strand (5 strands; 10 residues)	The half-hemolysis concentrations (the concentrations causing 50% hemolysis) of four cyclotides (kalata, circulin A, circulin B, cyclopsychotride) on human erythrocytes are all greater than 400 μM, among which circulin B and cyclopsychotride have relatively higher hemolytic activities, with half-hemolysis concentrations of 550 μM and 405 μM, respectively, while the half-hemolysis concentrations of kalata and circulin A are 1510 μM and 1020 μM, respectively.|||[Ref.10430870] EC50 = 1020 uM against blood type A human erythrocytes.|||[Ref.10430870] EC50 = 1020 uM against blood type A human erythrocytes.	"Experientia. 1965 Jun 15;21(6):307-8.PubMed.|||Experientia. 1965 Jun 15;21(6):307-8.doi: 10.1007/BF02144681.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||Experientia
. 1965 Jun 15;21(6):307-8. doi: 10.1007/BF02144681.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||10430870|||Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886.||Ref.10430870|||Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.||Ref.10430870|||18008336||Ref.10430870||Ref.18008336|||10430870|||Experientia. 1965 Jun 15;21(6):307-8.doi: 10.1007/BF02144681.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||Ref.10430870||Ref.18008336|||. 1965 Jun 15;21(6):307-8. doi: 10.1007/BF02144681.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886.Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.J. Mol. Biol. 1999; 285:333-345.Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8."	30	
FPDB00033	AP00275|||AP00275|||Circulin-B|||DRAMP00878|||AP00275|||DRAMP00878|||AP00275|||DRAMP00878	" 
GVIPCGESCVFIPCISTLLGCSCKNKVCYRN"	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-Gram- E. coli, activity value is MIC = 0.41 uM||Anti-P. aeruginosa, activity value is MIC = 25.5 uM||Anti-P. vulgaris, activity value is MIC = 6.8 uM||Anti-K. oxytoca, activity value is MIC = 8.2 uM||Anti-S. aureus, activity value is MIC = 13.5 uM||Anti-M.luteus, activity value is MIC > 500 uM||Anti-C.albicans, activity value is MIC > 500 uM||Anti-C. kefyr, activity value is MIC = 29 uM||Anti-and C.tropicalis, activity value is MIC > 500 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 13.5 uM||Anti-15.6). Fungi : Candida kefyr, activity value is MIC = 29 uM||Anti-H-salt = L-salt supplemented with 100000 uM NaCl. Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.04||Antimicrobial||Anti-Gram+||Anti-Gram-	Chassalia parviflora	Beta||Beta strand (5 strands; 10 residues)	[Ref.10430870] EC50 = 550 uM against blood type A human erythrocytes.	"Experientia. 1968 Jul 15;24(7):656-7. PubMed.|||Experientia. 1968 Jul 15;24(7):656-7. doi: 10.1007/BF02144681.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||Experientia
. 1968 Jul 15;24(7):656-7. doi: 10.1007/BF02138292.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||10430870|||10430870||Ref.10430870||Ref.18008336|||Experientia. 1968 Jul 15;24(7):656-7. doi: 10.1007/BF02138292.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||Ref.10430870||Ref.18008336|||1968 Jul 15;24(7):656-7. doi: 10.1007/BF02138292.||See ref AP00729, Tam JP et al. PNAS 96:8913-8|||Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.Biopolymers. 2008;90(1):51-60.Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. doi: 10.1006/bbrc.1996.1708."	31	
FPDB00034	AP00277|||AP00277|||Clavanin-B|||DRAMP02598|||Clavanin-B|||AP00277|||DRAMP02598	" 
VFQFLGRIIHHVGNFVHGFSHVF"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-L. monocytogenes EGD and C. albicans in radial diffusion assays . Recent microdilution assays revealed that the MIC value was reduced 32 fold against E. faecalis ATCC 29212, activity value is MIC = 8 ug/ml||Anti-while the activity against C. albicans ATCC 10231, activity value is MIC = 64 ug/ml||Antibacterial||Antimicrobial||Antifungal ; E.coli||L.monocytes||C.albicans	invertebrate Styela clava|||invertebrate Styela clava|||Styela clava [Sea squirt]|||Styela clava (Sea squirt)|||invertebrate Styela clava|||Styela clava (Sea squirt)	Alpha helix	N/A	"FEBS Lett. 1997; 400:158-162. PubMed.|||FEBS Lett. 1997; 400:158-162. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023|||FEBS Lett
. 1997 Jan 3;400(2):158-62. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023|||9001389|||FEBS Lett. 1997 Jan 3;400(2):158-162.|||9001389|||FEBS Lett. 1997; 400:158-162. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023|||FEBS Lett. 1997 Jan 3;400(2):158-162.|||1997 Jan 3;400(2):158-62. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023"	23	
FPDB00035	AP00283|||AP00283|||HBD3|||DRAMP03599|||AP00283	GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Chemotactic||Anti-MRSA||Anti-toxin||Anti-inflammatory||Channel inhibitors||Synergistic AMPs||Antibiofilm||Wound healing||Anticancer||Anti-An inducible human AMP. Active against E. coli DSM1103, activity value is MIC = 9.4 ug/ml||Anti-K. pneumoniae DSM681, activity value is MIC = 25 ug/ml||Anti-P. aeruginosa DSM1128, activity value is MIC = 18.75 ug/ml||Anti-S. aureus ATCC25923 or MRSA, activity value is MIC = 4.7 ug/ml||Anti-and S. pneumoniae DSM11865, activity value is MIC = 4.7 ug/ml||Anti-Escherichia coli DSM1103, activity value is MIC = 9.4 ug/ml||Anti-Klebsiella pneumoniae DSM681, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa DSM1128, activity value is MIC = 18.75 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 4.7 ug/ml||Anti-Streptococcus pneumoniae DSM11865, activity value is MIC = 4.7 ug/ml	skin, tonsils, oral/saliva, colonic mucosa, Homo sapiens|||skin, tonsils, oral/saliva, colonic mucosa, Homo sapiens|||Synthetic construct|||Homo sapiens (Human)|||skin, tonsils, oral/saliva, colonic mucosa, Homo sapiens	Combine Helix and Beta structure||Combine helix and strand structure	"Because several cationic antimicrobial peptides have been
reported to exhibit cytotoxic activity against eukaryotic cells,
hBD-3 was also assayed for hemolytic activity against human
erythrocytes. No significant hemolytic activity (,0.5%) was
observed using concentrations of hBD-3 up to 500000 ug/ml at
physiologic salt concentrations. However, significant hemolytic
activity was seen at high hBD-3 concentrations in 10000 uM so-dium
phosphate buffer containing 340000 uM sucrose|||Strong hemolytic activity (100% hemolysis at 10 μM)|||The document explicitly mentions the hemolytic values of human β-defensin 3 (hBD-3), with specific information as follows:

1. Under physiological saline conditions (phosphate-buffered saline, PBS):
When the concentration of hBD-3 reaches as high as 500 µg/ml, the hemolysis rate of human red blood cells is still **<0.5%**, showing no significant hemolytic activity.

2. In a specific buffer (10000 µM sodium phosphate buffer containing 340,000 µM sucrose, pH 7.4):
Significant hemolytic activity is only observed under high concentrations of hBD-3 (the specific concentration is not clearly marked as a fixed threshold and should be interpreted as far above physiologically relevant concentrations in the experimental context).

These results indicate that hBD-3 exhibits almost no hemolytic toxicity to human red blood cells under physiological saline conditions and only shows hemolytic activity at non-physiological high concentrations and in specific buffer systems, reflecting good biocompatibility.|||The document explicitly mentions the hemolytic values of human β-defensin 3 (hBD-3), as follows:

1. Under physiological saline conditions (phosphate-buffered saline, PBS)
Even when the concentration of hBD-3 reaches 500 µg/ml, the hemolysis rate of human red blood cells remains **<0.5%**, showing no significant hemolytic activity.

2. Hypotonic buffer containing 340,000 µM sucrose (10,000 µM sodium phosphate buffer, pH 7.4)
Significant hemolytic activity is observed only at relatively high concentrations of hBD-3, but this condition is a non-physiological hypotonic environment that does not correspond to in vivo physiological conditions.

These results indicate that hBD-3 exhibits no obvious cytotoxicity to eukaryotic cells (red blood cells) at physiologically relevant concentrations, and the risk of hemolysis is extremely low.|||At physiological salt concentrations, hBD-3 at concentrations up to 500 ug/ml did not exhibit significant hemolytic activity (&lt;0.5%); however, in 10000 uM sodium phosphate buffer containing 340000 uM sucrose, hBD-3 at high concentrations had significant hemolytic activity (specific values not clear)."	"J. Biol. Chem. 2001; 276:5707-5713|||Harder J, Bartels J, Christophers E, Schroeder JM.2001
 J. Biol. Chem. 2001; 276:5707-5713||ref see AP1315|||J. Biol. Chem. 2001; 276:5707-5713||ref see AP1315|||J. Biol. Chem. 2001; 276:5707-5713|||ref see AP1315|||J Biol Chem. 2001 Feb 23;276(8):5707-5713.||Ref.11085990|||J. Biol. Chem. 2001; 276:5707-5713||ref see AP1315"	45	
FPDB00036	AP00310|||AP00310|||LL-37|||LL-37|||AP00310	LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||Chemotactic||Anti-MRSA||Enzyme inhibitor||anti-TB||anti-sepsis||Synergistic AMPs||Hemolytic||Antibiofilm||Wound healing||Anticancer||Anti-L. monocytogenes EGD, activity value is MIC = 1.5 ug/ml||Antibacterial||Anti-S. aureusNCTC 6571, activity value is MIC = 19.3||Anti-E. coli ATCC 25922, activity value is MIC = 9.8||Anti-27367675: E.coli K88, activity value is MIC = 61||Anti-E.coli CVCC245, activity value is MIC = 61||Anti-S.aureus CVCC 26003, activity value is MIC = 36||Anti-S.aureus ATCC 25923, activity value is MIC = 58||Anti-Listeria monocytogene CVCC 1599, activity value is MIC = 13||Anti-Micrococcus luteus CVCC 28001, activity value is MIC = 90||Anti-A. baumannii ATCC 19606, activity value is MIC = 4 ug/ml||Anti-29022391 : S. mutans, activity value is MIC = 250 ug/ml||Anti-A. israelii, activity value is MIC = 7.81 ug/ml||Anti-E. faecalis, activity value is MIC = 2000 ug/ml||Anti-31417238: Streptococcus agalactiae NEM 316, activity value is MIC = 90||Anti-C-terminal:COOH): A. baumannii 6043, activity value is MIC = 14.2 uM||Anti-P. aeruginosa ATCC 19660, activity value is MIC = 28.5 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 28.5 uM||Anti-28649410: P. aeruginosa ATCC 9027, activity value is EC50 = 0.525 uM||Anti-P. aeruginosa PAO1 (pTDKGFP, activity value is EC50 = 0.599 uM||Anti-F. novicida U112, activity value is EC50 = 0.0534 uM||Anti-B. thailandensis E264, activity value is EC50 = 1.88 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 0.552 uM||Anti-31016971: Staphylococcus aureus SA113 WT, activity value is MIC = 256 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 256 uM	gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||Homo sapiens|||Homo sapiens [Human]|||Homo sapiens [Human]|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes	Helix	Moderate hemolytic activity (60% hemolysis at 50 μM)|||hRBC (4.47 (±0.35)% hemolysis at 175 ug/ml), Sheep RBC (HC₅₀=32 ± 0.68 ug/ml)|||hRBC (4.47 (±0.35)% hemolysis at 175 ug/ml), Sheep RBC = (HC50=32 ± 0.68 ug/ml)	"Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R. T.1996
 Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||Eur J Biochem
. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||28476579|||28408902, 30076860, 28400226, 27367675, 30076864, 30043322, 29022391, 31417238, 31396193, 31016971|||35254120|||28408902, 30076860, 28400226, 27367675, 30076864, 30043322, 29022391, 31417238, 31396193, 31016971||Refer 30076860||Refer PubMed ID: 30076864||Refer PubMed ID: 30043322|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed"	37	
FPDB00037	AP00325|||AP00325|||Uperin 3.6|||DRAMP20797	GVIDAAKKVVNVLKNLF	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-L. lactis, activity value is MIC = 3 ug/ml||Anti-S. uberis, activity value is MIC = 12.5 ug/ml||Anti-S. epidermidis, activity value is MIC = 12.5 ug/ml||Anti-B. cereus, activity value is MIC = 25 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-and L. innocua, activity value is MIC = 50 ug/ml||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 50 ug/ml||Anti-Pasteurella haemolytica, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 12 ug/ml||Anti-##Gram-negative bacterium: Pasteurella haemolytica, activity value is MIC = 25 ug/ml	Floodplain toadlet Uperoleia inundata, Australia|||Floodplain toadlet Uperoleia inundata, Australia|||Uperoleia mjobergii [Australian toadlet]|||Uperoleia mjobergii (Australian toadlet)|||Floodplain toadlet Uperoleia inundata, Australia	Helix||Alpha helix	No hemolysis information or data found in the reference(s) presented in this entry	Aust. J. Chem. 1996; 49:475-484. Publiser|||Aust. J. Chem. 1996; 49:475-484.|||Aust. J. Chem. 1996; 49:475-484. Publiser|||10461748|||J Pept Res. 1999 Aug;54(2):137-45.||Ref.10461748	17	
FPDB00038	AP00327|||AP00327|||Uperin-7.1|||DRAMP01161|||AP00327|||DRAMP01161	GWFDVVKHIASAV	Anti-Gram+||Antiviral||Anti-HIV||Antibacterial||Antimicrobial	Brown tree frog Litoria ewingi, Australia|||Brown tree frog Litoria ewingi, Australia|||Litoria ewingii [Brown tree frog]|||Litoria ewingi (Brown tree frog) (Ewing's tree frog)|||Brown tree frog Litoria ewingi, Australia|||Litoria ewingi (Brown tree frog) (Ewing's tree frog)	N/A	No hemolysis information or data found in the reference(s) presented in this entry	Aust. J. Chem. 1997; 50:889-894|||Aust. J. Chem. 1997; 50:889-894.|||Aust. J. Chem. 1997; 50:889-894|||Aust. J. Chem. 1997; 50:889-894.	13	
FPDB00039	AP00345|||AP00345|||Caerin-1.10|||AP00345|||DRAMP01577	GLLSVLGSVAKHVLPHVVPVIAEKL	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anticancer||Anti-a minor component that is not present in the glandular secretion of the female. Activity against B.cereus, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 6 uM||Anti-L. innocua, activity value is MIC = 50 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-or 29213, activity value is MIC > 100 ug/ml||Anti-S. epidermidis, activity value is MIC = 100 ug/ml||Anti-S. uberis, activity value is MIC = 50 ug/ml||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	Magnificent tree frog, Litoria splendida, Australia|||Magnificent tree frog, Litoria splendida, Australia|||Litoria splendida [magnificent tree frog]|||Litoria rothii [Roth's tree frog]|||Magnificent tree frog, Litoria splendida, Australia|||Litoria rothii (Roth's tree frog); also Litoria splendida (Magnificent tree frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||L. lactis ( MIC = 6 ug/ml ), L. innocua ( MIC = 50 ug/ml ), M. luteus ( MIC = 25 ug/ml ), S. uberis ( MIC = 50 ug/ml ) , P. multocida ( MIC = 100 ug/ml ), S. epidermidis ( MIC = 100 ug/ml )|||No hemolysis information or data found in the reference(s) presented in this entry	"Eur. J. Biochem. 2000; 267:269-275|||Wabnitz PA., Bowie JH, Tyler MJ, Wallace JC.2000, Australia
 Eur. J. Biochem. 2000; 267:269-275||same ref as AP2008||VanCompernolle et al., 2015|||Eur. J. Biochem. 2000; 267:269-275|||10601876|||16124032, 19539637|||Eur. J. Biochem. 2000; 267:269-275|||Peptides. 2015 Sep;71:296-303.Rapid Commun Mass Spectrom. 2005;19(18):2716-2724.Eur J Biochem. 2000 Jan;267(1):269-275."	25	
FPDB00040	AP00355|||DRAMP00341|||Ginkbilobin|||AP00355|||DRAMP00341|||AP00355|||DRAMP00341	ANTAFVSSAHNTQKIPAGAPFNRNLRAMLADLRQNAAFAG	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	seeds, Ginkgo biloba, Asia|||Ginkgo biloba (Ginkgo) (Maidenhair tree)|||Ginkgo biloba [Ginkgo]|||seeds, Ginkgo biloba, Asia|||Ginkgo biloba (Ginkgo) (Maidenhair tree)|||seeds, Ginkgo biloba, Asia|||Ginkgo biloba (Ginkgo) (Maidenhair tree)	N/A	No hemolysis information or data found in the reference(s) presented in this entry	Biochem. Biophys. Res. Commun. 2000; 279:407-411|||Biochem Biophys Res Commun. 2000 Dec 20;279(2):407-411.|||11118300|||Biochem. Biophys. Res. Commun. 2000; 279:407-411|||Biochem Biophys Res Commun. 2000 Dec 20;279(2):407-411.|||Biochem. Biophys. Res. Commun. 2000; 279:407-411|||Biochem Biophys Res Commun. 2000 Dec 20;279(2):407-411.	40	
FPDB00041	AP00384|||AP00384|||Ponericin-L2|||DRAMP02761|||AP00384|||DRAMP02761	LLKELWTKIKGAGKAVLGKIKGLL	"Anti-Gram+ & Gram-||Antiviral||Insecticidal||Anti-HIV||Anti-MRSA||Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 1.4 uM||Antibacterial||Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 6.5mm)||B. megaterium ATCC 9885b(Inhibition zone = 14mm)||B. stearothermophilus CIP 675(Inhibition zone = 21mm)||B. subtilis ATCC 6623(Inhibition zone = 13.5mm)||Enterococcus faecalis CIP 636(Inhibition zone = 4mm)||Lactococcus lactis ssp. cremoris I116(Inhibition zone = 15.5mm)||Streptococcus pyogenes CIP 561(Inhibition zone = 12.5mm)||S. sanguinis CIP 55128(Inhibition zone = 6mm)||Listeria ivanovii LMA 94d(Inhibition zone = 9.5mm)||Listeria monocytogenes ATCC 15313(Inhibition zone = 9.5mm)||Micrococcus luteus CIP 5345(Inhibition zone = 10.5mm)||Staphylococcus aureus CIP 677(Inhibition zone = 4.5mm)||Staphylococcus aureus LMA(Inhibition zone = 11mm)||S. epidermidis CIP 53134(Inhibition zone = 11.5mm);
Gram-negative bacteria: Escherichia coli(Inhibition zone = 4mm)||Enterobacter cloacae CIP 6085(Inhibition zone = 5mm)||Klebsiella pneumoniae CIP 8291(Inhibition zone = 3.5mm)||Proteus mirabilis LMA TP(Inhibition zone = 9mm)||Salmonella enterica CIP 813(Inhibition zone = 1.5mm)||Serratia marcescens LMA TP(Inhibition zone = 9mm)||Flavobacterium meningosepticum CIP 6057(Inhibition zone = 7mm)||Pseudomonas aeruginosa CIP A22(Inhibition zone = 14mm).||Antimicrobial||Anti-Gram+||Anti-Gram-"	ants, Pachycondyla goeldii|||ants, Pachycondyla goeldii|||Pachycondyla goeldii [Ponerine ant]|||Pachycondyla goeldii (Ponerine ant)|||ants, Pachycondyla goeldii|||Pachycondyla goeldii (Ponerine ant)	Helix||Alpha helix	"Weak hemolytic activity (20% hemolysis at 100 μM)|||The document explicitly mentions hemolytic data of 10 synthetic ponericin peptides (and crude venom) from Pachycondyla goeldii on sheep and horse erythrocytes. The core information is as follows (all tested concentrations were 400–500 µM, activity measured by hemolytic zone diameter, ""none"" means no hemolytic effect detected):

1. Hemolytic activity of crude venom

Caused complete hemolysis for both sheep and horse erythrocytes (specific hemolytic zone diameters not mentioned, only ""total lysis"" explicitly stated).

2. Hemolytic activity of each ponericin peptide family (classified by family)

(1) Ponericin G family (G1, G3, G4, G6)

No hemolytic activity: none of the 4 peptides (G1, G3, G4, G6) exhibited hemolysis against sheep or horse erythrocytes (marked as ""none"" or no hemolytic zone diameter in Table I).

(2) Ponericin W family (W1, W3-desK, W4, W5, W6)

This family is the only one showing hemolytic activity, with horse erythrocytes being more sensitive than sheep erythrocytes:

W1, W5, W6: Caused complete hemolysis for both sheep and horse erythrocytes (no specific diameters, text explicitly states ""total lysis of both horse and sheep erythrocytes"").
W3-desK: Hemolytic activity only against horse erythrocytes, none against sheep erythrocytes (no data for sheep in Table I; hemolytic activity shown for horse erythrocytes).
W4: Hemolytic activity only against horse erythrocytes, none against sheep erythrocytes (same trend as W3-desK).

(3) Ponericin L family (L2)

No hemolytic activity: no hemolysis detected against sheep or horse erythrocytes (no hemolytic zone diameter in Table I, text explicitly states ""no hemolytic action was found for L2"").

Additional notes

Detection method: Blood agar plate assay. Wells were punched into agar containing sheep or horse erythrocytes, 0.02 ml peptide solution added, incubated overnight at 4 °C, then left at room temperature for 24 h, and the diameter of complete hemolysis zones measured; absence of a hemolytic zone was considered as no hemolytic activity.
Species differences: All hemolytically active peptides (all from the W family) exhibited stronger hemolysis against horse erythrocytes, while sheep erythrocytes were more resistant to these peptides. This is related to species-specific differences in red blood cell membrane composition.|||Hemolysis experiment of horse and sheep red blood cells: At concentrations of 400-500 μM, the crude toxin and three synthetic peptides (W1, W5, W6) can cause complete hemolysis of horse and sheep red blood cells; W3-desK and W4 only exhibit hemolytic activity against horse red blood cells, with no obvious effect on sheep red blood cells; the remaining five synthetic peptides (G1, G3, G4, G6, L11) did not show hemolytic activity. However, the document did not specify the exact hemolysis rate values, only describing whether hemolysis occurred and the range of hemolysis.|||[Ref.11279030]Not found|||The document mentions hemolytic data of ponericins on horse and sheep red blood cells, as follows:

- Whole venom: hemolysis ring diameter of 6 mm for horse red blood cells, 3 mm for sheep red blood cells.

- Ponericin W1: causes complete hemolysis on both horse and sheep red blood cells (specific diameter not specified).

- Ponericin W5: causes complete hemolysis on both horse and sheep red blood cells (specific diameter not specified).

- Ponericin W6: hemolysis ring diameter of 4 mm for horse red blood cells, 1.5 mm for sheep red blood cells.

- Ponericin W3-desK: hemolytic effect only on horse red blood cells, hemolysis ring diameter of 2 mm; no hemolytic effect on sheep red blood cells.

- Ponericin W4: hemolytic effect only on horse red blood cells, hemolysis ring diameter of 2 mm; no hemolytic effect on sheep red blood cells.

- Ponericin G1, G3, G4, G6, L2: no hemolytic effect.

All the above data were measured at peptide concentrations of 400–500 μM, with hemolysis ring diameters in millimeters (mm).|||[Ref.11279030]Not found"	"J. Biol. Chem. 2001; 276: 17823-17829. PubMed.|||J. Biol. Chem. 2001; 276: 17823-17829. doi: 10.1074/jbc.M100216200. Epub 2001 Feb 22.|||J Biol Chem
. 2001 May 25;276(21):17823-9. doi: 10.1074/jbc.M100216200. Epub 2001 Feb 22|||11279030|||Ref.11279030|||J. Biol. Chem. 2001; 276: 17823-17829.|||J. Biol. Chem. 2001; 276: 17823-17829. PubMed.|||J. Biol. Chem. 2001; 276: 17823-17829."	24	
FPDB00042	AP00399|||AP00399|||Spinigerin|||DRAMP03181|||AP00399	HVDKKVADKVLLLKQLRIMRLLTRL	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-Bacillus megaterium, activity value is MIC = 0.8||Anti-Micrococcus luteus, activity value is MIC = 0.8||Anti-Escherichia coli SBS 363, activity value is MIC = 3||Anti-Escherichia coli D22, activity value is MIC = 3||Anti-Klebsiella pneumoniae, activity value is MIC = 50||Anti-Salmonella typhimurium, activity value is MIC = 3||Anti-Pseudomonas aeruginosa, activity value is MIC = 50||Anti-Trichoderma viride, activity value is MIC = 1.5||Anti-Neurospora crassa, activity value is MIC = 3||Anti-Neurospora crassa, activity value is MIC = 6||Anti-Fusarium culmorum, activity value is MIC = 1.5||Anti-Fusarium haematococcum, activity value is MIC = 0.4||Anti-Candida albicans, activity value is MIC = 3||Anti-Staphylococcus aureus USA 300, activity value is MIC > 81 uM||Anti-Escherichia coli K-12, activity value is MIC > 81 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 16 uM||Anti-Salmonella typhimurium KCTC 1926, activity value is MIC = 32 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 16 uM||Anti-Bacillus subtilis KCTC 3068, activity value is MIC = 2 uM||Anti-Staphylococcus epidermidis KCTC 1917, activity value is MIC = 8 uM||Anti-Staphylococcus aureus KCTC 1916, activity value is MIC = 8 uM||Anti-Bacillus subtilis ATCC 9372, activity value is MIC = 16||Anti-Bacillus anthracis Sterne 34F2, activity value is MIC = 35||Anti-Burkholderia thailandensis, activity value is MIC > 50 uM||Anti-Escherichia coli SBS363, activity value is MIC = 3||Anti-E. coli D22, activity value is MIC = 3||Anti-Nectria haematococca, activity value is MIC = 0.4	termite, Pseudacanthotermes spiniger|||termite, Pseudacanthotermes spiniger|||Pseudacanthotermes spiniger|||Pseudacanthotermes spiniger (Termite)|||termite, Pseudacanthotermes spiniger	Helix||Alpha helix	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% Cell death at >33.3 uM, Human erythrocytes (1% Hemolysis at 6.3 uM	J. Biol. Chem. 2001; 276:4085-4092|||J. Biol. Chem. 2001; 276:4085-4092|||20692130, 12963031|||Biopolymers. 2006 Feb 5;81(2):92-103.|||J. Biol. Chem. 2001; 276:4085-4092	25	
FPDB00043	AP00405|||AP00405|||Ranatuerin-6|||AP00405|||DRAMP02233	FISAIASMLGKFL	Anti-Gram+||Antiviral||Anti-HIV||Anti-S.aureus, activity value is MIC = 100 uM||Antimicrobial||Antibacterial	Rana catesbeiana, North America|||Rana catesbeiana, North America|||Rana catesbeiana [American bullfrog]|||Rana catesbeiana, North America|||Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)	N/A	"The document clearly states that at a concentration of 20 µg/ml, the tested ranatuerins 1-9 showed no detectable hemolytic activity on human red blood cells.|||ranatuerins information about the hemolysis of human red blood cells is mentioned in the document:

None of ranatuerins 1-9 exhibited detectable hemolytic activity against human erythrocytes at a concentration of 20 ug/ml.

The results showed that these antimicrobial peptides had no significant destructive effect on human red blood cells at the tested concentrations, reflecting a certain degree of biological safety.|||No hemolysis information or data found in the reference(s) presented in this entry"	"Biochem. Biophys. Res. Commun. 1998; 250: 589-592. PubMed.|||Biochem. Biophys. Res. Commun. 1998; 250: 589-592. doi: 10.1006/bbrc.1998.9362.|||Biochem Biophys Res Commun
. 1998 Sep 29;250(3):589-92. doi: 10.1006/bbrc.1998.9362.|||9784389|||Biochem. Biophys. Res. Commun. 1998; 250: 589-592. PubMed.|||Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592."	13	
FPDB00044	AP00408|||AP00408|||CAMPSQ432|||AP00408|||DRAMP02236	FLFPLITSFLSKVL	Anti-Gram+||Antiviral||Anti-HIV||Anti-MRSA||Anti-S. aureus or MRSA, activity value is MIC = 50 uM||Anti-S.aureus, activity value is MIC = 130 uM||Antimicrobial||Antibacterial	Rana catesbeiana, North America|||Rana catesbeiana, North America|||Rana catesbeiana [American bullfrog]|||Rana catesbeiana, North America|||Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)	N/A	"The document only mentions one hemolysis-related test result, with the key information as follows:

Hemolysis of Ranatuerins 1-9
All nine ranatuerin peptides (ranatuerin 1-9) isolated from the skin of American bullfrogs (Rana catesbeiana) showed no detectable hemolytic activity towards human erythrocytes at a concentration of 20 μg/ml (the text explicitly states: “showed no detectable hemolytic activity towards human erythrocytes”).

The document does not provide hemolysis data at other concentrations, nor does it mention hemolysis test results for erythrocytes of other species (such as sheep or horses).|||1|||The document mentions information related to the hemolytic activity of ranatuerins on human red blood cells:

Ranatuerins 1-9 showed no detectable hemolytic activity on human red blood cells at a concentration of 20 µg/ml.

These results indicate that these antimicrobial peptides do not cause significant damage to human red blood cells at the tested concentration, demonstrating a certain level of biosafety.|||No hemolysis information or data found in the reference(s) presented in this entry"	"Biochem. Biophys. Res. Commun. 1998; 250: 589-592. PubMed.|||Biochem. Biophys. Res. Commun. 1998; 250: 589-592. doi: 10.1006/bbrc.1998.9362.|||Biochem Biophys Res Commun
. 1998 Sep 29;250(3):589-92. doi: 10.1006/bbrc.1998.9362.|||9784389|||Biochem. Biophys. Res. Commun. 1998; 250: 589-592. PubMed.|||Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592."	14	
FPDB00045	AP00445|||AP00445|||RTD-1|||DRAMP02642|||AP00445|||DRAMP02642|||AP00445|||DRAMP02642	GFCRCLCRRGVCRCICTR	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Anti-toxin||Enzyme inhibitor||Active against S. aureus 502a or MRSA||L. monocytogenes||E. coli ML 35||S. typhimurium||C. albicans 16820||and C. neoformans. Theta-defensins are particularly important for antifungal activity of the granule extracts as alpha-defensins are poorly active (Tongaonkar P et al 2011 J Leuko Biol 89||283-90). It is also active against HIV-1. RTD-1 inhibits human Papillomavirus (hrHPV||nonenvelope DNA virus) infection through a mechanism involving capsid clustering that inhibits virions from binding to cell surface receptor complexes  .||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	leukocytes, Rhesus Macaque (Macaca mulatta)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus macaque)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus macaque)	Beta||Beta strand (4 strands; 10 residues)	Strong hemolytic activity (100% hemolysis at 5 μM)|||No hemolysis information or data found in the reference(s) presented in this entry	Science. 1999 Oct 15;286(5439):498-502|||Science. 1999 Oct 15;286(5439):498-502||Skeate et al., 2020|||Science. 1999 Oct 15;286(5439):498-502||Skeate et al., 2020|||11675394|||Science. 1999 Oct 15;286(5439):498-502.|||Science. 1999 Oct 15;286(5439):498-502||Skeate et al., 2020|||Science. 1999 Oct 15;286(5439):498-502.J Leukoc Biol. 2001 Sep;70(3):461-464.J Biol Chem. 2002 Feb 1;277(5):3079-3084.|||Science. 1999 Oct 15;286(5439):498-502|||Science. 1999 Oct 15;286(5439):498-502.	18	
FPDB00046	AP00449|||AP00449|||Alpha-MSH|||Alpha-MSH|||AP00449|||DRAMP02876	SYSMEHFRWGKPV	"Anti-Gram+||Antiviral||Antifungal||candidacidal||Anti-HIV||Antibacterial||Gram-positive bacterium: Staphylococcus aureus.
Yeast: Candida albicans.||Antimicrobial"	Brain, Homo sapiens|||Brain, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens [Human]|||Brain, Homo sapiens|||Bos taurus (Bovine)	N/A	"The document provides hemolytic values for some peptide compounds, as follows:

- DNal: Hemolysis rate is 7% ± 2.1% at a concentration of 100 μM.
- Peptide 3: Hemolysis rate is 23% ± 0.1% at a concentration of 100 μM.
- Peptide 4: Hemolysis rate is 30% ± 0.2% at a concentration of 100 μM.
- Peptide 8: Hemolysis rate is 24% ± 0.4% at a concentration of 100 μM.
- Peptide 9: Hemolysis rate is 49% ± 4.1% at a concentration of 100 μM.
- Peptide 10: Hemolysis rate is 34% ± 1% at a concentration of 100 μM.

These data indicate that different peptide compounds have varying hemolytic effects on red blood cells at different concentrations. Some peptides show certain hemolytic activity at higher concentrations, but the overall hemolysis rate is relatively low, suggesting a certain safety potential."	J Leukoc Biol 2000; 67(2): 233-9|||J Leukoc Biol 2000; 67(2): 233-9|||10670585|||10670585|||J Leukoc Biol 2000; 67(2): 233-9|||J Leukoc Biol 2000; 67(2): 233-239.	13	
FPDB00047	AP00451|||AP00451|||HBD1|||DRAMP02722	DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Channel inhibitors||Synergistic AMPs||Anticancer||While the reduced form is active against both Gram+ and Gram- bacteria||the oxidized form is only active against Gram- bacteria with little effect on cell envelope  . Interestingly||it inhibits the growth of clinical S. aureus strains but NOT lab strains. It was observed that hBD-1 from human platelets can cluster bacteria and signals NETs formation  .||Antimicrobial||Antibacterial	airway, hemofiltrates, urine, kidney; keratinocytes; skin; platelets; oral saliva; milk, mammary gland epithelium, colonic mucosa, Homo sapiens|||airway, hemofiltrates, urine, kidney; keratinocytes; skin; platelets; oral saliva; milk, mammary gland epithelium, colonic mucosa, Homo sapiens|||Synthetic construct	Combine Helix and Beta structure	Moderate hemolytic activity (50% hemolysis at 50 µM)	"FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed|||Bensch KW, Raida M, Mägert HJ, Schulz-Knappe P, Forssmann WG.1995
 FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||1995 Jul 17;368(2):331-5. doi: 10.1016/0014-5793(95)00687-5.||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||FEBS Lett. 1995 Jul 17;368(2):331-5. doi: 10.1016/0014-5793(95)00687-5.||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||FEBS Lett
. 1995 Jul 17;368(2):331-5. doi: 10.1016/0014-5793(95)00687-5.||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||Pongo pygmaeus (Bornean orangutan)||Immunogenetics. 2002 Feb;53(10-11):907-913.Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.|||FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed"	36	
FPDB00048	AP00473|||AP00473|||Piscidins p1|||Piscidin-1|||Moronecidin|||DRAMP02330|||AP00473|||AP00473|||Piscidin-1	FFHHIFRGIVHVGKTIHRLVTG	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-MRSA||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 12.5 uM||Anti-P. aeruginosa, activity value is MIC = 50 uM||Anti-B. subtilis, activity value is MIC = 12.5 uM||Anti-and S. aureus USA300 or MRSA, activity value is MIC = 1||Antibacterial||Anti-Enterococcus faecalis VRE, activity value is MIC = 5||Anti-E. faecalis, activity value is MIC = 2.5||Anti-Listeria monocytogenes, activity value is MIC = 2.5||Anti-Micrococcus luteus, activity value is MIC = 10||Anti-Staphylococcus aureus MRSA, activity value is MIC = 1.25||Anti-S. epidermitis, activity value is MIC = 5||Anti-S. saprophiticus, activity value is MIC = 5||Anti-Staphylococcus xylosus, activity value is MIC > 20 uM||Anti-S. agalactiae, activity value is MIC = 1.25||Anti-S. bovis, activity value is MIC = 1.25||Anti-S. equisimilis, activity value is MIC = 2.5||Anti-S. mitis, activity value is MIC = 1.25||Anti-S. Pneumonae, activity value is MIC = 1.25||Anti-S. pyrogenes, activity value is MIC = 1.25||Anti-Streptococcus iniae KST740 ak, activity value is MIC = 1.25||Anti-S. iniae KSTSi 6P, activity value is MIC = 1.25||Anti-Aeromonas hydrophila, activity value is MIC > 20 uM||Anti-Burkholderia cepacia, activity value is MIC > 20 uM||Anti-Vibrio Cholera, activity value is MIC = 2.5||Anti-Escherichia coli, activity value is MIC = 5||Anti-Enterobacter cloacae, activity value is MIC = 10||Anti-E. Aerogenes, activity value is MIC = 10||Anti-Klebsiella pneumoniae, activity value is MIC = 2.5||Anti-K. oxytoca, activity value is MIC = 5||Anti-Salmonella choleraesuis, activity value is MIC = 10||Anti-S. typhimurium, activity value is MIC = 10||Anti-S. arizonae, activity value is MIC = 10||Anti-Serratia marcescens, activity value is MIC > 20 uM||Anti-Shigella flexneri, activity value is MIC = 2.5||Anti-S. sonnei, activity value is MIC = 5||Anti-Yersinia enterocolitica, activity value is MIC = 2.5||Anti-Neurospora crassa, activity value is MIC = 1.56||Anti-A. fumigatus, activity value is MIC = 50||Anti-F. axysporum, activity value is MIC = 0.78||Anti-F. culmorum, activity value is MIC = 0.39||Anti-C. ablicans, activity value is MIC = 10||Anti-C. glabrata, activity value is MIC = 10||Anti-C. lusitania, activity value is MIC = 10||Anti-C. tropacalis, activity value is MIC = 10||Anti-Escherichia coli, activity value is MIC = 3.1 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 25 ug/ml||Anti-Clinical strain of colistin-resistant A. baumannii, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 1.5 ug/ml||Anti-Clinical strain of methicillin resistant Staphylococcus aureus, activity value is MIC = 3.1 ug/ml	mainly mast cells, gill, skin, intestine, spleen, and anterior kidney, hybrid striped bass (Morone saxatilis x Morone chrysops); Morone saxatilis|||mainly mast cells, gill, skin, intestine, spleen, and anterior kidney, hybrid striped bass (Morone saxatilis x Morone chrysops); Morone saxatilis|||Hybrid striped bass|||Morone chrysops x Morone saxatilis|||Lates calcarifer [Asian sea bass]|||Morone saxatilis (Striped bass)|||mainly mast cells, gill, skin, intestine, spleen, and anterior kidney, hybrid striped bass (Morone saxatilis x Morone chrysops); Morone saxatilis|||mainly mast cells, gill, skin, intestine, spleen, and anterior kidney, hybrid striped bass (Morone saxatilis x Morone chrysops); Morone saxatilis|||Morone chrysops x Morone saxatilis	Helix	"The document provides information on the hemolytic properties of piscidins (fish-derived antimicrobial peptide) only through the hemolytic activity comparison curve (Figure 1c), without clearly indicating a specific 50% hemolytic concentration (HC₅₀) value. The core comparison results are as follows: 
 
1. Trends in Hemolytic Activity of Major Peptides (Testing Human Red Blood Cells)
 
piscidins (P1, P2, P3): Hemolytic activity increases with concentration, all higher than the antibacterial peptide magainin 2 but lower than the metin peptide mellitin (mellitin has weaker antibacterial activity but stronger hemolytic activity). 
Among them, piscidin 3 is the member with the lowest hemolytic activity in the piscidin family, and its structure is speculated to be related — histidine (His) at position 17 is replaced by glycine (Gly), disrupting amphiphilic α-helix structure, reducing amphiphilic activity, and thereby weakening hemolytic ability. 
Magainin 2 (control, sourced from the clawed toad): At the same concentration, hemolytic rates were significantly lower than all piscidins. 
mellitin (control, source of bee venom): At the same concentration, its hemolytic rate is significantly higher than all piscidins, making it the peptide with the strongest hemolytic activity among the three. 
 
2. Key Points
 
The document only shows relative hemolysis capacity using the ""concentration-hemolysis rate"" curve (horizontal axis 1-1000 μg/ml, vertical axis 0%-100%), without providing precise hemolysis rate values corresponding to specific concentrations (such as hemolysis percentage at a certain concentration), nor calculating and recording HC₅₀ (the peptide concentration causing 50% hemolysis of red blood cells) as a core quantitative indicator.|||The document provides some hemolytic values, as follows:

- Piscidins 1-3: At concentrations of 1-1000 μg/ml, there are differences in hemolysis rates on human red blood cells. Among them, piscidin 3 has a relatively lower hemolysis rate, which may be related to the substitution of histidine at position 17 in its structure with glycine, disrupting the amphipathic α-helix structure.
- Magainin 2: The hemolytic activity is lower than that of piscidins, and the hemolysis rate is relatively low within the same concentration range.
- Melittin: The hemolytic activity is relatively strong, with a higher hemolysis rate at higher concentrations, but its antibacterial activity is comparatively weaker.

These data indicate that the hemolytic activity of different peptide antibiotics is closely related to structural features, and the integrity of the amphipathic α-helix may be an important factor affecting hemolytic activity.|||Human RBCs (100% hemolysis at 100 ug/ml)|||human RBC ( 57 ug/ml)|||In Document 10 (NATURE 2001), piscidin family antimicrobial peptides (piscidin 1, piscidin 2, piscidin 3) isolated from the tissues of hybrid striped bass (Morone saxatilis × M. chrysops) exhibit hemolytic activity, with hemolytic capacity stronger than magainin 2 derived from Xenopus but weaker than melittin; among them, piscidin 3 has the lowest hemolytic activity, and its hemolytic ability is related to the integrity of the amphipathic α-helical structure.|||The document mentions the hemolytic data of piscidins, magainin 2, and mellitin, as follows:

- Piscidins 1-3 (P1, P2, P3): At a concentration of 1 µg/ml, the hemolysis rate is close to 0; at 10 µg/ml, the hemolysis rate is about 10%-30% (with P3 having the lowest hemolysis rate); at 100 µg/ml, the hemolysis rate is about 40%-70%; at 1000 µg/ml, the hemolysis rate is about 70%-90%.

- Magainin 2 (Mag 2): Hemolysis is lower than that of piscidins, with a hemolysis rate of about 40% at 1000 µg/ml.

- Mellitin: The most hemolytic, showing some hemolysis even at 1 µg/ml, and almost 100% hemolysis at 100 µg/ml.

The above data are presented in Figure 1c (human red blood cell hemolytic activity curve), showing the hemolysis percentages of each peptide at different concentrations.|||Human RBCs (100% hemolysis at 100 ug/ml)"	"Nature 2001; 414, 268 - 269; doi:10.1038/35104690. (PubMed)|||Silphaduang U, Noga E.J.2001
 Nature 2001; 414, 268 - 269; doi:10.1038/35104690. (PubMed)||Kim JP et al 2010|||Nature 2001; 414, 268 - 269; doi:10.1038/35104690.||Kim JP et al 2010|||Nature 2001; 414, 268 - 269; doi:10.1038/35104690. (PubMed)|||Nature
. 2001 Nov 15;414(6861):268-9. doi: 10.1038/35104690.||Kim JP et al 2010|||31653020|||31354312, 30021422|||30365554|||Nature. 2001 Nov 15;414(6861):268-269.||Ref.11713517|||Nature 2001; 414, 268 - 269; doi:10.1038/35104690. (PubMed)||Kim JP et al 2010|||Nature 2001; 414, 268 - 269; doi:10.1038/35104690. (PubMed)|||31354312, 30021422||Refer PubMed ID: 30021422"	22	
FPDB00049	AP00497|||AP00497|||Maximin-H5|||DRAMP01127	ILGPVLGLVSDTLDDVLGIL	Anti-Gram+||Antiviral||Anti-HIV||Anticancer||Anti-S. aureus, activity value is MIC = 90 uM||Anti-T98G, activity value is EC50 = 125 uM||Antibacterial ; Bombina maxima [Giant fire-bellied toad]||Antibacterial||Antimicrobial	Bombina maxima, China, Asia|||Bombina maxima, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	N/A	"Hemolytic assay was tested with rabbit red cells
in liquid medium as reported [12]. Serial dilutions of the peptides were
used, and after incubation at 37 _x0002_C for 0.5 h, the cells were centri-fuged
and the absorbance in the supernatant was measured at 595 nm.
Maximum hemolysis was determined by adding 1% Triton X-100 to a
sample of cells.|||In the hemolysis experiment targeting the anionic antimicrobial peptide Maximin H5 from the toad (Bombina maxima), no hemolysis of rabbit red blood cells was observed at a concentration as high as 80 μM, that is, the hemolytic value was: no hemolysis at a concentration of 80 μM."	"Biochem Biophys Res Commun 2002 Jul 26;295(4):796-9|||Lai R, Liu H, Hui Lee W, Zhang Y.2002
 Biochem Biophys Res Commun 2002 Jul 26;295(4):796-9||Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346|||Biochem Biophys Res Commun 2002 Jul 26;295(4):796-9|||Biochem Biophys Res Commun 2002 Jul 26;295(4):796-9|||https://pubmed.ncbi.nlm.nih.gov/12127963|||Biochem Biophys Res Commun 2002 Jul 26;295(4):796-799."	20	
FPDB00050	AP00499|||AP00499|||Gramicidin A|||DRAMP00245|||AP00499|||DRAMP00245	VGALAVVVWLWLWLW	Anti-Gram+ & Gram-||Antiviral||Spermicidal||Anti-HIV||Anticancer||This peptide shows effects on HIV and HSV infections (Arch Virol 1997; 142: 2225-35). gA also has anticancer effect.||Antimicrobial||Antbacterial	soil bacterium, Bacillus brevis|||soil bacterium, Bacillus brevis|||Bacillus brevis|||Bacillus brevis (soil bacterium) (Gram-positive bacteria)|||soil bacterium, Bacillus brevis|||Bacillus brevis (soil bacterium) (Gram-positive bacteria)	Helix||Beta strand (1 strands; 13 residues)	No hemolysis information or data found in the reference(s) presented in this entry	"J Exp Med. 1939 Jun 30;70(1):1-10|||Dubos RJ1939
 J Exp Med. 1939 Jun 30;70(1):1-10|||J Exp Med. 1939 Jun 30;70(1):1-10|||19870884|||J Exp Med. 1939 Jun 30;70(1):1-10.J Biomol NMR. 1996 Jul;8(1):1-14.|||J Exp Med. 1939 Jun 30;70(1):1-10|||J Exp Med. 1939 Jun 30;70(1):1-10.J Biomol NMR. 1996 Jul;8(1):1-14."	15	
FPDB00051	AP00505|||AP00505|||Histatin5|||DRAMP03580|||Histatin5|||AP00505|||DRAMP03580	DSHAKRHHGYKRKFHEKHHSHRGY	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Enzyme inhibitor||Anti-C. albicans, activity value is LD50 = 2.3 ug/ml||Anti-and E. faecium . Also active against bacteria A.actinomycetemcomitans, activity value is ED50 > 100 uM||Anti-S. mutans cariogenic bacteria, activity value is ED50 = 92 uM||Anti-C. albicans DIS or azole resistant, activity value is ED50 = 6.4||Anti-C. glabrata or fluconazole resistant, activity value is ED50 = 38.7||Anti-C. krusei, activity value is ED50 = 6.47 uM||Anti-and C. neoformans CN2 or amphotericin B resistant, activity value is ED50 = 3.71||Anti-and S. cerevisiae, activity value is MIC = 74 uM||Antibacterial||Antimicrobial||Anti-Streptococcus mutans U159, activity value is MIC = 234 ug/ml||Anti-Candida albicans ATCC10231, activity value is IC50 = 8.5 ug/ml||Anti-31417503: C. albicans ATCC 90028, activity value is MIC = 64.45 ug/ml||Anti-11302797: Candida albicans, activity value is LD50 = 7.3	salivary glands, Homo sapiens|||salivary glands, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||Homo sapiens [Human]|||salivary glands, Homo sapiens|||Homo sapiens (Human)	Helix||Alpha helix	Streptococcus mutans U159 (MIC= 234 ug/ml), Candida albicans ATCC10231 (IC50= 8.5 ug/ml); Refer PubMed ID- 31417503: C. albicans ATCC 90028 (MIC = 64.45 ug/ml); Refer PubMed ID- 11302797: Candida albicans (LD50 = 7.3 ± 0.52 ug/ml); Refer PubMed ID- 3286634: C. albicans ( 100 % inhibition at 54 nmol)	J Biol Chem. 1988 Jun 5;263(16):7472-7.|||J Biol Chem. 1988 Jun 5;263(16):7472-7.||Data from ref for AP504||Du H et al., 2017||Luque-Ortega et al., 2008|||J Biol Chem. 1988 Jun 5;263(16):7472-7.||Data from ref for AP504||Du H et al., 2017||Luque-Ortega et al., 2008|||34417532, 33740624, 31417503, 11302797, 3286634|||J Biol Chem. 1988 Jun 5;263(16):7472-7477.|||34417532, 33740624, 31417503, 11302797, 3286634|||J Biol Chem. 1988 Jun 5;263(16):7472-7.||Data from ref for AP504||Du H et al., 2017||Luque-Ortega et al., 2008|||J Biol Chem. 1988 Jun 5;263(16):7472-7477.	24	
FPDB00052	AP00512|||DRAMP01047|||Shepherin II|||AP00512|||DRAMP01047	GYHGGHGGHGGGYNGGGGHGGHGGGYNGGGHHGGGGHG	"Anti-Gram-||Antiviral||Antifungal||Anti-HIV
Crucial residues:||Anti-Gram- E. herbicola, activity value is IC50 = 25 ug/ml||Anti-E. coli, activity value is IC50 < 2.5 ug/ml||Anti-P. putida, activity value is IC50 < 2.5 ug/ml||Anti-P. syringae, activity value is IC50 < 2.5 ug/ml||Anti-S. typhimurium, activity value is IC50 = 65 ug/ml||Anti-Serratia sp, activity value is IC50 < 2.5 ug/ml||Anti-B.subtilis, activity value is IC50 > 100 ug/ml||Anti-S.aureus, activity value is IC50 > 100 ug/ml||Anti-S.mutans, activity value is IC50 > 100 ug/ml||Anti-C. albicans, activity value is IC50 = 5 ug/ml||Anti-C. neoformans, activity value is IC50 < 2.5 ug/ml||Anti-S. cerevisiae, activity value is IC50 = 3 ug/ml||Anti-A.alternata, activity value is IC50 > 100 ug/ml||Anti-A. flavus, activity value is IC50 = 60 ug/ml||Anti-A.fumigatus, activity value is IC50 > 100 ug/ml||Anti-and F. culmorum, activity value is IC50 = 68 ug/ml||Antimicrobial||Antibacterial||Antifungal ; Erwinia herbicola (IC(50) = 25 ug/ml)||Escherichia coli (IC(50) < 2.5 ug/ml)||Pseudomonas putida (IC(50) < 2.5 ug/ml)||Pseudomonas syringae (IC(50) < 2.5 ug/ml)||Salmonella typhimurium (IC(50) = 65 ug/ml)||Serratia sp. (IC(50) < 2.5 ug/ml)||Candida albicans (IC(50) = 5 ug/ml)||Cryptococcus neoformans (IC(50) < 2.5 ug/ml)||Saccharomyces cerevisiae (IC(50) = 3 ug/ml)||Aspergillus flavus (IC(50) = 60 ug/ml)||Fusarium culmorum (IC(50) = 68 ug/ml)||Anti-HIV"	roots, shepherd's purse, Capsella bursa-pastoris|||roots, shepherd's purse, Capsella bursa-pastoris|||Capsella bursa-pastoris (shepherd's purse)|||Capsella bursa-pastoris [Shepherd purse]|||roots, shepherd's purse, Capsella bursa-pastoris|||Capsella bursa-pastoris (shepherd's purse)	Rich	N/A	"Plant Mol Biol. 2000 Sep;44(2):187-97. Pub-Med.|||Plant Mol Biol. 2000 Sep;44(2):187-97.  doi: 10.1023/a:1006431320677.|||Plant Mol Biol
. 2000 Sep;44(2):187-97. doi: 10.1023/a:1006431320677.|||Plant Mol Biol. 2000 Sep;44(2):187-197.|||11117262|||Plant Mol Biol. 2000 Sep;44(2):187-97. Pub-Med.|||Plant Mol Biol. 2000 Sep;44(2):187-197."	38	
FPDB00053	AP00524|||AP00524|||HBD2|||Human beta-defensin-2 WT hBD - 2|||AP00524|||DRAMP03598	" 
GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Chemotactic||Anti-toxin||Channel inhibitors||Synergistic AMPs||Antibiofilm||Wound healing||Anti-synthetic: Active against E. coli DSM1103, activity value is MIC = 18.8 ug/ml||Anti-K. pneumoniae DSM681, activity value is MIC = 37.5 ug/ml||Anti-P. aeruginosa DSM1128, activity value is MIC = 25 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 100 ug/ml||Anti-and S.pneumoniae DSM11865, activity value is MIC = 300 ug/ml||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	airway, skin, lung, trachea epithelia, and uterus, oral (saliva); Homo sapiens|||airway, skin, lung, trachea epithelia, and uterus, oral (saliva); Homo sapiens|||Synthetic construct|||Homo sapiens [Human]|||airway, skin, lung, trachea epithelia, and uterus, oral (saliva); Homo sapiens|||Homo sapiens (Human)	Combine Helix and Beta structure	[Ref.15625724] It is slightly hemolytic (<12%) against human erythrocytes at the highest concentration of 500 ug/ml.	"Nature. 1997 Jun 26;387(6636):861. PubMed.|||1997 Jun 26;387(6636):861. doi: 10.1038/43088.||see ref AP1315|||Nature. 1997 Jun 26;387(6636):861. doi: 10.1038/43088.|||Nature
. 1997 Jun 26;387(6636):861. doi: 10.1038/43088.||see ref AP1315|||9727055|||Nature. 1997 Jun 26;387(6636):861. PubMed.|||Nature. 1997 Jun 26;387(6636):861.J Biol Chem. 2000 Oct 20;275(42):32911-32918.Plant Cell Rep. 2007 Aug;26(8):1391-1398."	41	
FPDB00054	AP00532|||AP00532|||Lunatusin|||DRAMP01010|||Lunatusin|||AP00532|||DRAMP01010|||AP00532|||DRAMP01010	KTCENLADTFRGPCFATSNC	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anticancer||Anti-a minor component that is not present in the glandular secretion of the female. Activity against B.cereus, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 6 uM||Anti-L. innocua, activity value is MIC = 50 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-or 29213, activity value is MIC > 100 ug/ml||Anti-S. epidermidis, activity value is MIC = 100 ug/ml||Anti-S. uberis, activity value is MIC = 50 ug/ml||Antibacterial||Antifungal ; Phaseolus lunatus L [Lima bean]||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal ; Fusarium oxysporum||Mycosphaerella arachidicola||Botrytis cinerea||Bacillus megaterium||Bacillus subtilis||Proteus vulgaris||Mycobacterium phlei	Phaseolus lunatus L. (lima bean)|||Phaseolus lunatus L. (lima bean)|||Phaseolus lunatus L [Lima bean]|||Phaseolus lunatus L.(Chinese lima bean)|||Phaseolus lunatus L. (lima bean)|||Phaseolus vulgaris cv. white cloud beans|||Phaseolus lunatus L. (lima bean)|||Phaseolus lunatus L.(Chinese lima bean)	N/A	No hemolysis information or data found in the reference(s) presented in this entry	"Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.|||Jack Ho Wong and Tzi Bun Ng2005
 Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.||same ref as AP2008||VanCompernolle et al., 2015|||Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.|||Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.|||https://pubmed.ncbi.nlm.nih.gov/16269344|||Peptides. 2005 Nov;26(11):2086-2092.|||16269344|||Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.|||Peptides. 2005 Nov;26(11):2086-2092.|||Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.|||Peptides. 2005 Nov;26(11):2086-2092."	20	
FPDB00055	AP00553|||AP00553|||Sesquin|||DRAMP00409|||Sesquin|||AP00553|||DRAMP00409|||AP00553|||CAMPSQ7|||DRAMP00409	" 
KTCENLADTY"	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anticancer||Active against fungi B. cinerea||F.oxysporum||and M. arachidicola. Inhibit leukemia cells M1 and breast cancer cells MCF-7. HIV (50 uM inhibit 35%).||Anti-Botrytis cinerea, activity value is IC50 = 2.5 uM||Anti-Fusarium oxysporum, activity value is IC50 = 1.4 uM||Anti-Mycosphaerella arachidicola, activity value is IC50 = 0.15 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral ; N.A	Seeds, Vigna sesquipedalis, ground bean|||Seeds, Vigna sesquipedalis, ground bean|||Synthetic construct|||Vigna unguiculata subsp. sesquipedalis (Yard-Long bean)|||Vigna unguiculata subsp. sesquipedalis|||Seeds, Vigna sesquipedalis, ground bean|||Vigna unguiculata subsp. sesquipedalis (Yard-Long bean)|||Seeds, Vigna sesquipedalis, ground bean|||Vigna unguiculata subsp. sesquipedalis  [Cowpea]|||Vigna unguiculata subsp. sesquipedalis (Yard-Long bean)	N/A	No hemolysis information or data found in the reference(s) presented in this entry	"Peptides. 2005 Jul;26(7):1120-6|||Wong JH, Ng TB2005
 Peptides. 2005 Jul;26(7):1120-6|||Peptides. 2005 Jul;26(7):1120-6|||Peptides. 2005 Jul;26(7):1120-6|||15949629|||Peptides. 2005 Jul;26(7):1120-1126.|||http://www.ncbi.nlm.nih.gov/protein/109894868|||Peptides. 2005 Jul;26(7):1120-6|||Peptides. 2005 Jul;26(7):1120-1126.|||Peptides. 2005 Jul;26(7):1120-6|||15949629|||Peptides. 2005 Jul;26(7):1120-1126."	10	
FPDB00056	AP00590|||Siamycin II|||AP00590|||DRAMP18350|||Siamycin II	" 
CLGIGSCNDFAGCGYAIVCFW"	Antiviral||Anti-HIV||Anti-Staphylococcus aureus FDA209P JC-1, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus smith, activity value is MIC = 6.3 ug/ml||Anti-Staphylococcus aureus A15036, activity value is MIC = 3.1 ug/ml||Anti-Micrococcus luteus ATCC 9341, activity value is MIC = 1.6 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 1.6 ug/ml||Anti-Escherichia coli Juhl, activity value is MIC > 100 ug/ml||Anti-E. coli K12, activity value is MIC > 100 ug/ml||Anti-E. coli NIHJ JC-2, activity value is MIC > 100 ug/ml||Anti-K. pneumoniae ATCC 10031, activity value is MIC > 100 ug/ml||Anti-Citrobacter freundii GN 7391, activity value is MIC > 100 ug/ml||Anti-Salmonella typhi 901, activity value is MIC > 100 ug/ml||Anti-P. aeruginosa A9843A, activity value is MIC > 100 ug/ml||Antimicrobial||Antiviral ; HIV-1	Streptomyces strains AA3891|||Streptomyces strain AA6532	Beta||Beta strand	No hemolysis information or data found in the reference(s) presented in this entry	J Biomol NMR. 1995 Apr;5(3):271-86. PubMed.|||J Biomol NMR. 1995 Apr;5(3):271-86. doi: 10.1007/BF00211754.|||8557614|||J Biomol NMR. 1995 Apr;5(3):271-86. PubMed.|||J Biomol NMR. 1995 Apr;5(3):271-86.|||7787424	21	
FPDB00057	AP00599|||AP00599|||Brevinin-2-related peptide|||DRAMP01873|||Brevinin-2-related peptide|||AP00599|||DRAMP01873	GIWDTIKSMGKVFAGKILQNL	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Anti-E. coli, activity value is MIC = 13||Anti-S. aureus or MRSA, activity value is MIC = 25 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Anti-Escherichia coli, activity value is MIC = 13 uM||Anti-Staphylococcus aureus, activity value is MIC = 25 uM||Anti-Candida albicans, activity value is MIC = 25 uM||Anti-19793185 : E. coli, activity value is MIC = 6.25 uM||Anti-S. aureus, activity value is MIC = 12.5 uM||Anti-A. baumannii, activity value is MIC = 6.25 uM||Anti-31549575 : Staphylococcus aureus, activity value is MIC = 16||Anti-Escherichia coli, activity value is MIC = 32 uM||Anti-Candida albicans, activity value is MIC = 16 uM||Anti-Candida albicans, activity value is MIC = 70 uM	mink frog, Rana septentrionalis, North America|||Rana septentrionalis (mink frog)|||mink frog, Rana septentrionalis, North America|||Rana septentrionalis (mink frog)	N/A	"The document explicitly provides the hemolytic values of five major antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), expressed as the concentration required to induce 50% hemolysis of human red blood cells (HC₅₀). The specific data are as follows:

Brevinin-1SPa: The hemolytic concentration HC₅₀ is 7 μM, and its minimum inhibitory concentrations (MICs) against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans) are 13 μM, 3 μM, and 6 μM, respectively.
Brevinin-1SPb: hemolytic activity, HC₅₀ = 25 μM; MIC values against Escherichia coli, Staphylococcus aureus, and Candida albicans are 50 μM, 6 μM, and 13 μM, respectively.
Brevinin-1SPd: hemolytic activity HC₅₀ = 8 μM; the MIC values against Escherichia coli, Staphylococcus aureus, and Candida albicans are all 3 μM.
Temporin-1SPb: hemolytic activity, HC₅₀ = 60 μM; only a MIC of 6 μM against Staphylococcus aureus was detected, while the MICs against Escherichia coli and Candida albicans were not determined (ND).
Brevinin-2-related peptide: hemolytic activity, HC₅₀ = 70 µM; MIC values against Escherichia coli, Staphylococcus aureus, and Candida albicans are 13 µM, 25 µM, and 25 µM, respectively.|||The document mentioned hemolysis-related content, and the specific hemolytic values are as follows:

- Brevinin-1SPa: The concentration causing 50% hemolysis of human red blood cells (HC₅₀) is 7 μM.
- Brevinin-1SPb: HC₅₀ is 25 μM.
- Brevinin-1SPd: HC₅₀ is 8 μM.
- Temporin-1SPb: HC₅₀ is 60 μM.
- Brevinin-2 related peptides: HC₅₀ is 71 μM.|||Human erythrocytes ( HC50 = 70 uM ); Refer PubMed ID - 19793185: hRBC(LC50= 90 uM)|||In Document 2 (Comparative Biochemistry and Physiology, Part C 2004), among the antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), brevinin-1SPa has an HC₅₀ of 7 μM for human red blood cells, brevinin-1SPb has an HC₅₀ of 25 μM, brevinin-1SPd has an HC₅₀ of 8 μM, temporin-1SPb has an HC₅₀ of 60 μM, and brevinin-2 related peptide has an HC₅₀ of 70 μM.|||[Ref.15556063]HC50=70 uM against human erythrocytes|||Human erythrocytes ( HC50 = 70 uM ); Refer PubMed ID - 19793185: hRBC(LC50= 90 uM)|||[Ref.15556063]HC50=70 uM against human erythrocytes|||The document mentions the hemolytic activity values of several antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), expressed as HC_{50}, which is the peptide concentration causing 50% hemolysis. The details are as follows:

- Brevinin-1SPa: HC_{50} = 7 μM

- Brevinin-1SPb: HC_{50} = 25 μM

- Brevinin-1SPd: HC_{50} = 8 μM

- Temporin-1SPb: HC_{50} = 60 μM

- Brevinin-2-related peptide: HC_{50} = 70 μM

These values reflect the hemolytic capability of different peptides on human red blood cells; the lower the value, the stronger the hemolytic activity."	Comp. Biochem. Physiol. C 2004; 139: 31-38|||omp. Biochem. Physiol. C 2004; 139: 31-38|||15556063, 19793185, 31549575|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.||Ref.15556063|||15556063||Ref.15556063|||15556063, 19793185, 31549575|||Comp. Biochem. Physiol. C 2004; 139: 31-38|||Ref.15556063	21	
FPDB00058	AP00640|||AP00640|||Maculatin-1.3|||DRAMP01366|||AP00640|||DRAMP01366	" 
GLLGLLGSVVSHVVPAIVGHF"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anticancer||Anti-S. aureus USA300 MRSA, activity value is MIC = 6.2 uM||Anti-E.coli, activity value is MIC > 100 uM||Anti-B. subtilis, activity value is MIC = 25 uM||Anti-and P.aeruginosa, activity value is MIC > 100 uM||Anti-MRSA||Antibacterial||Antimicrobial	Anti-Gram+ & Gram-, Antiviral, Anti-HIV, Anticancer|||Litoria eucnemis, Australia|||Litoria eucnemis, Australia|||Litoria eucnemis, Australia|||Litoria eucnemis [Australian anurans]|||Litoria eucnemis (Australian anurans)|||Litoria eucnemis, Australia|||Litoria eucnemis (Australian anurans)	N/A	"The document clearly provides the hemolytic values of two types of peptides in the skin secretions of the European common frog (Rana temporaria) (expressed as the concentration causing hemolytic effect on human red blood cells). The specific data are as follows:

1. Brevinin-1 family peptides
Brevinin-1T, Brevinin-1Ta: They have hemolytic activity, but the document does not provide specific concentration values, only mentioning that both have dual antibacterial and hemolytic activity and were initially isolated from the skin secretions of the European common frog.
Brevinin-1Tb: No clear hemolytic value is provided; it is only mentioned that it has antibacterial activity against Staphylococcus aureus (concentration 7.6 uM) and no activity against Salmonella enterica serovar typhimurium, with no hemolytic data mentioned.
New Brevinin-1Tc (specific to the Slovenian population): Hemolytic values have not been directly measured, but its bioactivity is inferred to be similar to that of Brevinin-1T, 1Ta, and 1Tb through 2D mass spectrometry mapping (NMD-NIS coordinates), potentially having hemolytic activity, but the specific concentration is unknown.

2. Melittin-related peptides (MRP-1)
Hemolytic value: Lethal concentration (LC) for human red blood cells is 0.5 uM, which is a potent hemolytic agent, present in both Moscow and Slovenian populations, and can serve as a species biomarker for the European common frog.

3. Temporin family peptides
Known temporins (A, B, L, etc.): Only described as having ""low"" hemolytic activity (for example, temporins A and B are active against Gram-positive bacteria and fungi but have weak hemolytic activity) or mentioning that temporin L has hemolytic activity against human red blood cells, with no specific HC_{50} or LC values provided.
Six new temporins (O, P, Q, R, S, T, specific to the Slovenian population): Bioactivity inferred through 2D mass spectrometry mapping:
Short-chain new temporins (O, T): Similar activity to temporins A and B, low hemolytic activity, no specific values;
Long-chain new temporins (Q, R, S): Activity similar to temporin L (which has hemolytic activity), but no specific hemolytic concentration measured;
temporin P: Due to the absence of basic amino acid residues in the sequence, it is inferred to have no hemolytic activity or extremely weak activity, with no specific values.|||The document only mentions the hemolytic information of caerin 1.1, specifically: caerin 1.1 lyses red blood cells at >250 μg/ml, meaning that the peptide lyses red blood cells at concentrations above 250 μg/ml, but does not specify the exact hemolytic values such as the half-maximal hemolytic concentration (HC₅₀). 

For other antimicrobial peptides (such as aureins, citropins, maculatins, etc.), the descriptions mainly involve antibacterial, anticancer, antifungal activities, and do not mention hemolytic values.|||No hemolysis information or data found in the reference(s) presented in this entry"	Peptides. 2004 Jun;25(6):1035-54.|||Peptides. 2004 Jun;25(6):1035-54|||Peptides. 2004 Jun;25(6):1035-54.||Menousek et al., 2012|||Peptides. 2004 Jun;25(6):1035-54.|||Peptides. 2004 Jun;25(6):1035-54||Menousek et al., 2012|||15203252|||Peptides. 2004; 25: 1035-1054.|||Peptides. 2004 Jun;25(6):1035-54.|||Peptides. 2004; 25: 1035-1054.	21	
FPDB00059	AP00663|||DRAMP01517|||AP00663|||DRAMP01517	GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC	Anti-Gram-||Antiviral||Anti-HIV||Anti-Escherichia coli, activity value is MIC = 10 uM||Antimicrobial||Antibacterial	North American frog, Rana pipiens|||Rana pipiens (northern leopard frog)|||North American frog, Rana pipiens|||Rana pipiens (northern leopard frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||No hemolysis information or data found in the reference(s) presented in this entry	"Eur J Biochem. 2000 Feb;267(3):894-900. PubMed.|||Eur J Biochem. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Eur J Biochem
. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Ref.10651828||Ref.11601906|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed.|||Virology. 2001 Sep 30;288(2):351-7.Eur J Biochem. 2000 Feb;267(3):894-900."	37	
FPDB00060	AP00706	GLLASLGKVFGGYLAEKLKPK	Anti-Gram+ & Gram-||Antiviral||Anti-HIV	Litoria dahlii, Australia	N/A	N/A	"Rapid Commun Mass Spectrom. 2001;15(18):1726-34. PubMed.|||Rapid Commun Mass Spectrom. 2001;15(18):1726-34. doi: 10.1002/rcm.429.|||Rapid Commun Mass Spectrom
. 2001;15(18):1726-34. doi: 10.1002/rcm.429."	21	
FPDB00061	AP00708|||AP00708|||GF-17|||GI-17	GFKRIVQRIKDFLRNLV	Anti-Gram+ & Gram-||Antiviral||Spermicidal||Anti-HIV||Anti-MRSA||Synergistic AMPs||Anticancer||Anti-and S. aureus USA300 MRSA, activity value is MIC = 3.1||Anti-E. faecium ATCC 51559, activity value is MIC = 3.1 uM||Anti-S. aureus USA300, activity value is MIC = 3.1 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 3.1 uM||Anti-A. baumannii B28-16, activity value is MIC = 3.1 uM||Anti-P. aeruginosa PAO1, activity value is MIC = 12.5 uM||Anti-E. cloacae B2366-1, activity value is MIC = 3.1 uM||Anti-S. aureus Newman, activity value is MIC = 1.6 uM||Anti-S. aureus Mu50, activity value is MIC = 1.6 uM||Anti-S. aureus UAMS1, activity value is MIC = 3.1 uM||Anti-E. faecium V284-17, activity value is MIC = 2 uM||Anti-S. aureus USA300, activity value is MIC = 2||Anti-A. baumannii B28-16, activity value is MIC = 4 uM||Anti-P. aeruginosa E411-17, activity value is MIC = 16 uM||Anti-E. coli E423-17, activity value is MIC = 16 uM	Derivative of LL-37; NMR-based discovery; Sequence truncation. human cathelicidin analog, animal-derived, natural derivative|||Derivative of LL-37; NMR-based discovery; Sequence truncation. human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct	Helix	Moderate hemolytic activity (55% hemolysis at 50 μM)|||Human RBCs [Hemolytic concentration (HL50) = 180 uM]|||Human RBC (65% hemolysis at 200 uM)	"J Am Chem Soc. 2006 May 3;128(17):5776-85. PubMed.|||J Am Chem Soc. 2006 May 3;128(17):5776-85. PubMed|||J Am Chem Soc. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875.||Golla R. et al., 2020|||J Am Chem Soc. 2006 May 3;128(17):5776-85. PubMed.|||J Am Chem Soc
. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875.||Golla R. et al., 2020|||31319057|||34959645"	17	
FPDB00062	AP00724|||AP00724|||RTD-2|||DRAMP31352|||AP00724|||DRAMP31352	" 
GVCRCLCRRGVCRCLCRR"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Antibacterial||Antimicrobial	Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta (Rhesus macaque)	Bridge	Strong hemolytic activity (100% hemolysis at 5 μM)	J Leukoc Biol 2001; 70:461-464|||J Leukoc Biol 2001; 70:461-464|||11675394|||J Immunol. 2004 Jul 1;173(1):515-20.|||J Leukoc Biol 2001; 70:461-464|||J Immunol. 2004 Jul 1;173(1):515-20.	18	
FPDB00063	AP00725|||AP00725|||Rhesus theta defensin-1/3, subunit A precursor|||DRAMP31353|||AP00725|||Rhesus theta defensin-1/3, subunit A precursor|||DRAMP31353	" 
GFCRCICTRGFCRCICTR"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Antibacterial||Antimicrobial||Antiviral ; Staphylococcus aureus 502a||Escherichia coli ML35||and yeast forms of Candida albicans 16820 and Cryptococcus neoformans 271A||HIV	Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)	Bridge	Strong hemolytic activity (100% hemolysis at 5 μM)	J Leukoc Biol 2001; 70:461-464|||J Leukoc Biol 2001; 70:461-464|||11675394|||J Immunol. 2004 Jul 1;173(1):515-20.|||J Leukoc Biol 2001; 70:461-464|||https://pubmed.ncbi.nlm.nih.gov/11675394|||J Immunol. 2004 Jul 1;173(1):515-20.	18	
FPDB00064	AP00764|||AP00764|||Dermaseptin-S9|||DRAMP01682	GLRSKIWLWVLLMIWQESNKFKKM	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Chemotactic||Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 31.6 uM||Antibacterial||Antimicrobial	South America, hylid frog, Phyllomedusa sauvagei|||South America, hylid frog, Phyllomedusa sauvagei|||Phyllomedusa sauvagei [Sauvage's leaf frog]|||Phyllomedusa sauvagei (South American hylid frog)	Helix	N/A	Biochemistry 2006; 45: 468-480|||Biochemistry 2006; 45: 468-480|||16401077|||Biochemistry. 2006 Jan 17;45(2):468-480.	24	
FPDB00065	AP00729|||Kalata B1|||DRAMP00856|||Kalata B1|||AP00729|||DRAMP00856|||AP00729|||DRAMP00856|||Kalata B1	GLPVCGETCVGGTCNTPGCTCSWPVCTRN	Anti-Gram+ & Gram-||Antiviral||Antifungal||Insecticidal||Anti-HIV||Enzyme inhibitor||Hemolytic||Anti-Gram- E.coli, activity value is MIC > 500 uM||Anti-P.aeruginosa, activity value is MIC > 500 uM||Anti-P.vulgaris, activity value is MIC > 500 uM||Anti-K. oxytoca, activity value is MIC = 54.8 uM||Anti-S. aureus, activity value is MIC = 0.26 uM||Anti-M. luteus, activity value is MIC = 40.4 uM||Anti-C.albicans, activity value is MIC > 500 uM||Anti-C. kefyr, activity value is MIC = 21.4 uM||Anti-and C.tropicalis, activity value is MIC > 500 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC > 500 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 500 uM||Anti-Proteus vulgaris ATCC 49132, activity value is MIC > 500 uM||Anti-Klebsiella oxytoca ATCC 49131, activity value is MIC = 54.8 uM||Anti-Staphylococcus aureus 29213, activity value is MIC = 0.26 uM||Anti-Micrococcus luteus ATCC 49732, activity value is MIC = 40.4 uM||Anti-Candida albicans ATCC 37092, activity value is MIC > 500 uM||Anti-Candida kefyr ATCC 37095, activity value is MIC = 21.4 uM||Anti-Candida tropicalis ATCC 37097, activity value is MIC > 500 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 40 uM||Anti-Staphylococcus aureus, activity value is MIC = 0.26 uM||Anti-Micrococcus luteus, activity value is MIC = 40.4 uM||Anti-Klebsiella oxytoca, activity value is MIC = 54.8 uM||Anti-Candida kefyr, activity value is MIC = 21.4 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-HIV, activity value is EC50 = 0.66 uM	African herb, Oldenlandia affinis|||Oldenlandia affinis|||Oldenlandia affinis|||African herb, Oldenlandia affinis|||African herb, Oldenlandia affinis|||Oldenlandia affinis|||Viola yedoensis	Beta||Beta strand (3 strands; 7 residues)	"Human blood type A erythrocytes|||The half-hemolysis concentrations (the concentrations causing 50% hemolysis) of four cyclotides (kalata, circulin A, circulin B, cyclopsychotride) on human erythrocytes are all greater than 400 μM, among which circulin B and cyclopsychotride have relatively higher hemolytic activities, with half-hemolysis concentrations of 550 μM and 405 μM, respectively, while the half-hemolysis concentrations of kalata and circulin A are 1510 μM and 1020 μM, respectively.|||[Ref.12779323] HD50 = 300 uM against Human type A red blood cells.|||Human blood type A erythrocytes|||EC₅₀=1510 uM|||[Ref.12779323] HD50 = 300 uM against Human type A red blood cells.|||The document mentions the hemolytic values of four cyclotides (kalata, circulin A, circulin B, cyclopsychotride), as follows:

- The concentration at which all four cyclotides cause 50% hemolysis of human red blood cells is greater than 400 μM.

- Among them, circulin B and cyclopsychotride have relatively higher hemolytic activity, with 50% hemolysis concentrations of 550 μM and 405 μM, respectively; kalata and circulin A have lower hemolytic activity, with 50% hemolysis concentrations of 1510 μM and 1020 μM, respectively.

These data come from hemolysis experiments, in which the hemolytic effects of different concentrations of peptides on human type A red blood cells were measured, and the 50% hemolysis concentration (EC₅₀) was determined from the dose-response curve.|||[Ref.12779323] HD50 = 300 uM against Human type A red blood cells."	Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8.PubMed.|||Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8.doi: 10.1073/pnas.96.16.8913.||see ref|||10430870|||28669767|||Biopolymers. 2008;90(1):51-60.||Ref.10430870|||18008336||Ref.10430870||Ref.18008336|||10430870|||Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8.PubMed.||see ref|||Ref.10430870||Ref.18008336|||Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8.PubMed.|||Biopolymers. 2008;90(1):51-60.Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.Biochemistry. 1995 Apr 4;34(13):4147-4158.J Biol Chem. 2012 Dec 21;287(52):43884-98.|||https://pubmed.ncbi.nlm.nih.gov/18081258	29	
FPDB00066	AP00730|||DRAMP00863|||AP00730|||DRAMP00863|||Kalata-B8	GSVLNCGETCLLGTCYTTGCTCNKYRVCTKD	Antiviral||Anti-HIV||Hemolytic||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 2.5 uM||Antimicrobial||Antiviral ; HIV	African herb, Oldenlandia affinis|||Staphylococcus warneri ISK-1|||African herb, Oldenlandia affinis|||Oldenlandia affinis	Beta||Beta strand (3 strands; 7 residues)	[Ref.20564013] It produced 7% hemolysis at the 62 uM.	Biochem J 2006; 393: 619-626|||Biosci Biotechnol Biochem. 2000 Nov;64(11):2420-8.Vet Microbiol. 2010 Nov 20;146(1-2):124-31.|||Biochem J 2006; 393: 619-626|||Biopolymers. 2008;90(1):51-60.Biochem J. 2006 Feb 1;393(Pt 3):619-626.Chembiochem. 2007 Jun 18;8(9):1001-1011.|||https://pubmed.ncbi.nlm.nih.gov/16207177	31	
FPDB00067	AP01022|||DRAMP00799|||AP01022|||DRAMP00799|||Cycloviolin-A	" 
GVIPCGESCVFIPCISAAIGCSCKNKVCYRN"	Antiviral||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.13 uM||Antimicrobial	Leonia cymosa|||Clitoria ternatea (Butterfly pea)|||Leonia cymosa|||Leonia cymosa (Sacha uba)	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Org Chem. 2000 Jan 14;65(1):124-8|||J Biol Chem. 2011 Jul 8;286(27):24275-24287.|||J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10813905	31	
FPDB00068	AP01023|||DRAMP00800|||AP01023|||DRAMP00800|||Cycloviolin-B	GTACGESCYVLPCFTVGCTCTSSQCFKN	Antiviral||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.13 uM||Antimicrobial||Antiviral ; HIV	Leonia cymosa|||Clitoria ternatea (Butterfly pea)|||Leonia cymosa|||Leonia cymosa (Sacha uba)|||Synthetic construct	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Org Chem. 2000 Jan 14;65(1):124-8|||J Biol Chem. 2011 Jul 8;286(27):24275-24287.|||J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10813905	28	
FPDB00069	AP01024|||DRAMP00801|||AP01024|||DRAMP00801|||Cycloviolin-C	GIPCGESCVFIPCLTTVAGCSCKNKVCYRN	Antiviral||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.13 uM||Antimicrobial	Leonia cymosa|||Leonia cymosa (Sacha uba)|||Leonia cymosa|||Leonia cymosa (Sacha uba)	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10813905	30	
FPDB00070	AP01025|||DRAMP00802|||AP01025|||DRAMP00802|||Cycloviolin-D	" 
GFPCGESCVFIPCISAAIGCSCKNKVCYRN"	Antiviral||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.13 uM||Antimicrobial	Leonia cymosa|||Leonia cymosa (Sacha uba)|||Leonia cymosa|||Leonia cymosa (Sacha uba)	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10813905	30	
FPDB00071	AP01030|||AP01030|||DRAMP00788|||Varv E	" 
GLPICGETCVGGTCNTPGCSCSWPVCTRN"	Antiviral||Anti-HIV||Hemolytic||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.35 uM||Anti-cancer||Anti-HIV, activity value is EC50 = 0.35 uM	Viola arvensis|||Viola arvensis|||Viola arvensis (European field pansy) (Field violet)|||Viola yedoensis	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 1999 Feb;62(2):283-6. Pub-Med.|||J Nat Prod. 1999 Feb;62(2):283-6. doi: 10.1021/np9803878.||Ireland et al., 2008|||J Nat Prod. 1999 Feb;62(2):283-6. Pub-Med.|||Biopolymers. 2008;90(1):51-60.J Nat Prod. 1999 Feb;62(2):283-286.J Nat Prod. 2004 Feb;67(2):144-147.Peptides. 2010 Aug;31(8):1434-40|||https://pubmed.ncbi.nlm.nih.gov/18081258	29	
FPDB00072	AP01034|||DRAMP00803|||AP01034|||DRAMP00803	" 
GDPTFCGETCRVIPVCTYSAALGCTCDDRSDGLCKRN"	Antiviral||Anti-HIV||Antimicrobial	Palicourea condensata|||Leonia cymosa (Sacha uba)|||Palicourea condensata|||Palicourea condensata (Cappel)	Combine Helix and Beta structure||Combine helix and strand structure	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2001 Feb;64(2):249-50.|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||J Nat Prod. 2001 Feb;64(2):249-50.|||J Nat Prod. 2001 Feb;64(2):249-250.Structure. 2004 Jan;12(1):85-94.Biopolymers. 2008;90(1):51-60.	37	
FPDB00073	AP01058|||DRAMP00875|||AP01058|||DRAMP00875|||Vhl-1	" 
SISCGESCAMISFCFTEVIGCSCKNKVCYLN"	Antiviral||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.87 uM||Antimicrobial	Viola hederaceae|||Macadamia integrifolia (Macadamia nut)|||Viola hederaceae|||Viola hederacea (Australian violet)|||Viola hederacea	Combine Helix and Beta structure||Combine helix and strand structure	No hemolysis information or data found in the reference(s) presented in this entry	J Biol Chem. 2005 Jun 10;280(23):22395-405. Pub-Med.|||J Biol Chem. 2005 Jun 10;280(23):22395-405. doi: 10.1074/jbc.M501737200. Epub 2005 Apr 11.||Ireland et al., 2008|||Plant J. 1999 Sep;19(6):699-710.|||J Biol Chem. 2005 Jun 10;280(23):22395-405. Pub-Med.|||Biopolymers. 2008;90(1):51-60.J Biol Chem. 2005 Jun 10;280(23):22395-22405.|||https://pubmed.ncbi.nlm.nih.gov/15824119	31	
FPDB00074	AP01060|||DRAMP00879|||AP01060|||DRAMP00879|||Circulin C	GIPCGESCVFIPCITSVAGCSCKSKVCYRN	Antiviral||Anti-HIV||Anti-HIV-1 strain IIIB/CEM-SS cell, activity value is EC50 = 0.073 uM||Anti-H1122 strain/MT-2 cell, activity value is EC50 = 0.048 uM||Anti-and A17 strain/MT-2, activity value is EC50 = 0.247 uM||Antimicrobial||Anti-HIV-1, activity value is EC50 = 50	tropical tree Chassalia parvifolia|||Viola hederacea (Australian violet)|||tropical tree Chassalia parvifolia|||Chassalia parviflora|||Chassalia parvifolia	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-8. doi: 10.1021/np990432r.|||J Biol Chem. 2005 Jun 10;280(23):22395-22405.Aust. J. Chem. 2010;63:771-778.|||J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10691702	30	
FPDB00075	AP01061|||DRAMP00880|||AP01061|||DRAMP00880|||Circulin D	" 
KIPCGESCVWIPCVTSIFNCKCKENKVCYHD"	Antiviral||Anti-HIV||Circulins C-F showed anti HIV-1 effect with EC50 values (concentration for 50% inhibition) in the range from 50 to 0.275 uM||depending upon the particular virus strain and host cell line used in the assay.||Antimicrobial||Anti-HIV-1, activity value is EC50 = 50	tropical tree Chassalia parvifolia|||Chassalia parviflora|||tropical tree Chassalia parvifolia|||Chassalia parviflora|||Chassalia parvifolia	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-8. doi: 10.1021/np990432r.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10691702	31	
FPDB00076	AP01062|||DRAMP00881|||AP01062|||DRAMP00881|||Circulin-E	" 
KIPCGESCVWIPCLTSVFNCKCENKVCYHD"	Antiviral||Anti-HIV||Circulins C-F showed anti HIV-1 effect with EC50 values (concentration for 50% inhibition) in the range from 50 to 0.275 uM||depending upon the particular virus strain and host cell line used in the assay.||Antimicrobial	tropical tree Chassalia parvifolia|||Chassalia parviflora|||tropical tree Chassalia parvifolia|||Chassalia parviflora	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-8. doi: 10.1021/np990432r.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10691702	30	
FPDB00077	AP01063|||DRAMP00882|||AP01063|||DRAMP00882|||Circulin F	KVCYRAIPCGESCVWIPCISAAIGCSCKN	Antiviral||Anti-HIV||Circulins C-F showed anti HIV-1 effect with EC50 values (concentration for 50% inhibition) in the range from 50 to 0.275 uM||depending upon the particular virus strain and host cell line used in the assay.||Antimicrobial||Anti-HIV-1, activity value is EC50 = 50	tropical tree Chassalia parvifolia|||Chassalia parviflora|||tropical tree Chassalia parvifolia|||Chassalia parviflora|||Chassalia parvifolia	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-8. doi: 10.1021/np990432r.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10691702	29	
FPDB00078	AP01064|||AP01064|||DRAMP00816|||DRAMP00816	" 
GIPCGESCVWIPCISAAIGCSCKSKVCYRN"	Antiviral||Antifungal||Antiparasitic||Anti-HIV||Active against nematode parasites of sheep (e.g. Haemonchus contortus or Trichostrongylus colubriformis).||Insecticidal	Viola odorata|||Viola odorata|||Viola odorata (Sweet violet)|||Viola odorata (Sweet violet)	Bridge	"Peptides were dissolved in water and serially diluted in PBS to give 0.02 ml test solutions in a 96-well U-bottomed microtitre plate (Nunc). Human type A RBCs (red blood cells) were washed with PBS and centrifuged at 1500000000 ug for 60 s in a microcentrifuge several times until a clear supernatant was obtained. A 0.25% suspension of washed RBCs in PBS (0.1 ml) was added to the peptide solutions. The plate was incubated at 37◦Cfor 1 h and centrifuged at 150000000 ug for 0.083333 h. Aliquots of 0.1 mlweretransferred to a 96-well flat-bottomed microtitre plate (Falcon) and the absorbance was measured at 405 nm with an automatic Multiskan Ascent plate reader (Labsystems). The amount of haemolysis was calculated as the percentage ofmaximum lysis (1%Triton X-100 control) after adjusting for minimum lysis (PBS control). Synthetic melittin (Sigma) was used for comparison. The haemolytic dose necessary to lyse 50% of the RBCs (HD50) was calculated using the regression constant from the linear portion of the haemolytic titration curve (Graphpad Prism software).|||The document mentions hemolysis-related data for various cyclic peptides isolated from Viola odorata, as follows:

- cycloviolacin O2: At a concentration of 25 µM, the hemolysis rate is about 40%, and the half-hemolysis concentration (HD_{50}) is about 36 µM.

- cycloviolacin O13: At a concentration of 25 µM, the hemolysis rate is about 60%, and the HD_{50} is about 11 µM.

- cycloviolacin O14: At a concentration of 25 µM, the hemolysis rate is about 11%, making it the cyclic peptide with the lowest hemolysis among the new peptides.

- cycloviolacin O15: At a concentration of 25 µM, the hemolysis rate is about 25%.

- cycloviolacin O24: At a concentration of 25 µM, the hemolysis rate is about 75%, making it the cyclic peptide with the highest hemolysis among the new peptides.

- varv A: At a concentration of 25 µM, the hemolysis rate is about 50%.

- kalata B1: At a concentration of 25 µM, the hemolysis rate is about 30%.

These data were obtained through hemolysis experiments using human type A red blood cells as the experimental subject, with 1% Triton X-100 treated group as the maximum hemolysis control and PBS treated group as the minimum hemolysis control, and the hemolysis percentage was calculated accordingly.|||[Ref:16872274] It has 50% hemolytic activity at 1 uM and 75% hemolytic activity at 1.5 uM against human type A red blood cells|||[Ref:16872274] It has 50% hemolytic activity at 1 uM and 75% hemolytic activity at 1.5 uM against human type A red blood cells"	Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12. doi: 10.1042/BJ20060627.|||Biochem J. 2006 Nov 15;400(1):1-12.Biopolymers. 2008;90(1):51-60.	30	
FPDB00079	AP01065|||AP01065|||DRAMP00817|||DRAMP00817	GSIPACGESCFKGKCYTPGCSCSKYPLCAKN	Antiviral||Antiparasitic||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.44 uM||Insecticidal	Viola odorata|||Viola odorata|||Viola odorata (Sweet violet)|||Viola odorata (Sweet violet)	Combine||Combine helix and strand structure	"The document mentions hemolysis-related data for various cyclic peptides isolated from Viola odorata, as follows:

- cycloviolacin O2: At a concentration of 25 µM, the hemolysis rate is about 40%, and the half-hemolysis concentration (HD_{50}) is about 36 µM.

- cycloviolacin O13: At a concentration of 25 µM, the hemolysis rate is about 60%, and the HD_{50} is about 11 µM.

- cycloviolacin O14: At a concentration of 25 µM, the hemolysis rate is about 11%, making it the cyclic peptide with the lowest hemolysis among the new peptides.

- cycloviolacin O15: At a concentration of 25 µM, the hemolysis rate is about 25%.

- cycloviolacin O24: At a concentration of 25 µM, the hemolysis rate is about 75%, making it the cyclic peptide with the highest hemolysis among the new peptides.

- varv A: At a concentration of 25 µM, the hemolysis rate is about 50%.

- kalata B1: At a concentration of 25 µM, the hemolysis rate is about 30%.

These data were obtained through hemolysis experiments using human type A red blood cells as the experimental subject, with 1% Triton X-100 treated group as the maximum hemolysis control and PBS treated group as the minimum hemolysis control, and the hemolysis percentage was calculated accordingly.|||[Ref:16872274] It has 3% hemolytic activity at 1 uM and 13% hemolytic activity at 1.5 uM against human type A red blood cells|||[Ref:16872274] It has 3% hemolytic activity at 1 uM and 13% hemolytic activity at 1.5 uM against human type A red blood cells"	Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12. doi: 10.1042/BJ20060627.||Ireland et al., 2008|||Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12.Biopolymers. 2008;90(1):51-60.|||Biochem J. 2006 Nov 15;400(1):1-12.Biopolymers. 2008;90(1):51-60.	31	
FPDB00080	AP01066|||AP01066|||DRAMP00828	GLPTCGETCFGGTCNTPGCTCDPWPVCTHN	Antiviral||Anti-HIV||Hemolytic||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.308 uM||Insecticidal	Viola odorata|||Viola odorata|||Viola odorata (Sweet violet)	Bridge	"The document mentions hemolysis-related data of cyclic peptides isolated from Viola yedoensis, as follows:

- Kalata B1: half-hemolysis concentration (HD_{50}) is 11.7 µM, 95% confidence interval 10.2–13.4 µM.

- Cycloviolacin Y4: HD_{50} is 9.3 µM, 95% confidence interval 7.7–11.1 µM.

- Cycloviolacin Y5: HD_{50} is 8.7 µM, 95% confidence interval 7.4–10.2 µM.

- Cycloviolacin Y1: within the tested concentration range, hemolysis is significantly lower than the above cyclic peptides and is the lowest among them.

- Melittin (positive control): HD_{50} is 0.94 µM, 95% confidence interval 0.9–0.97 µM, with hemolysis much higher than the tested cyclic peptides.

These data were obtained via hemolysis experiments using human type A red blood cells, with 1% Triton X-100 treatment as the maximum hemolysis control and PBS treatment as the minimum hemolysis control, and the hemolysis percentage was calculated.|||[Ref:16872274] It has 75% hemolytic activity at 25 uM against human type A red blood cells."	Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12. doi: 10.1042/BJ20060627.||Ireland et al., 2008|||Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12.Biopolymers. 2008;90(1):51-60.|||Biochem J. 2006 Nov 15;400(1):1-12.##Biopolymers. 2008;90(1):51-60.	30	
FPDB00081	AP01077|||DRAMP00833|||AP01077|||DRAMP00833|||Cycloviolacin Y1	" 
GGTIFDCGETCFLGTCYTPGCSCGNYGFCYGTN"	Antiviral||Anti-HIV||Hemolytic||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 1.21 uM||Antimicrobial||Anti-HIV, activity value is EC50 = 1.2 uM	Chinese herb Viola yedoensis and Viola odorata|||Pelophylax esculentus (Edible frog) (Rana esculenta)|||Chinese herb Viola yedoensis and Viola odorata|||Viola yedoensis (Chinese herb)|||Viola yedoensis	Bridge	"The document mentions hemolysis-related data of cyclic peptides isolated from Viola yedoensis, as follows:

- Kalata B1: half-hemolysis concentration (HD_{50}) is 11.7 µM, 95% confidence interval 10.2–13.4 µM.

- Cycloviolacin Y4: HD_{50} is 9.3 µM, 95% confidence interval 7.7–11.1 µM.

- Cycloviolacin Y5: HD_{50} is 8.7 µM, 95% confidence interval 7.4–10.2 µM.

- Cycloviolacin Y1: within the tested concentration range, hemolysis is significantly lower than the above cyclic peptides and is the lowest among them.

- Melittin (positive control): HD_{50} is 0.94 µM, 95% confidence interval 0.9–0.97 µM, with hemolysis much higher than the tested cyclic peptides.

These data were obtained via hemolysis experiments using human type A red blood cells, with 1% Triton X-100 treatment as the maximum hemolysis control and PBS treatment as the minimum hemolysis control, and the hemolysis percentage was calculated.|||[Ref.18081258] It has hemolytic activity.|||Human type A erythrocytes ( IC50 > 4.5 uM )"	J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52. doi: 10.1021/np70393000000 ug. Epub 2007 Dec 15.||Ireland et al., 2008|||J. Biol. Chem. 269:11956-11961(1994)|||J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52.  Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/18081258	33	
FPDB00082	AP01080|||DRAMP00836|||AP01080|||DRAMP00836|||Cycloviolacin Y4	" 
GVPCGESCVFIPCITGVIGCSCSSNVCYLN"	Antiviral||Anti-HIV||Hemolytic||Antimicrobial||Anti-HIV, activity value is EC50 = 0.12 uM	Chinese herb Viola yedoensis and Viola odorata|||Chinese herb Viola yedoensis|||Viola hederacea (Australian violet)|||Chinese herb Viola yedoensis|||Viola yedoensis (Chinese herb)|||Viola yedoensis	Bridge	"The document mentions hemolysis-related data of cyclic peptides isolated from Viola yedoensis, as follows:

- Kalata B1: half-hemolysis concentration (HD_{50}) is 11.7 µM, 95% confidence interval 10.2–13.4 µM.

- Cycloviolacin Y4: HD_{50} is 9.3 µM, 95% confidence interval 7.7–11.1 µM.

- Cycloviolacin Y5: HD_{50} is 8.7 µM, 95% confidence interval 7.4–10.2 µM.

- Cycloviolacin Y1: within the tested concentration range, hemolysis is significantly lower than the above cyclic peptides and is the lowest among them.

- Melittin (positive control): HD_{50} is 0.94 µM, 95% confidence interval 0.9–0.97 µM, with hemolysis much higher than the tested cyclic peptides.

These data were obtained via hemolysis experiments using human type A red blood cells, with 1% Triton X-100 treatment as the maximum hemolysis control and PBS treatment as the minimum hemolysis control, and the hemolysis percentage was calculated.|||[Ref:18081258] HD50=9.3 uM against human type A red blood cells."	J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52. doi: 10.1021/np70393000000 ug. Epub 2007 Dec 15.|||J Mol Biol. 1999 Dec 17;294(5):1327-1336.|||J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52.Biopolymers. 2008;90(1):51-60.Chembiochem. 2008 Aug 11;9(12):1939-45. doi: 10.1002/cbic.200800174.|||https://pubmed.ncbi.nlm.nih.gov/18081258	30	
FPDB00083	AP01081|||DRAMP00837|||AP01081|||DRAMP00837|||Cycloviolacin Y5	GIPCAESCVWIPCTVTALVGCSCSDKVCYN	Antiviral||Anti-HIV||Hemolytic||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.04 uM||Antimicrobial||Anti-HIV, activity value is EC50 = 0.04 uM	Chinese herb Viola yedoensis and Viola odorata|||Chinese herb Viola yedoensis|||Viola yedoensis (Chinese herb)|||Chinese herb Viola yedoensis|||Viola yedoensis (Chinese herb)|||Viola yedoensis	Bridge	"The document mentions hemolysis-related data of cyclic peptides isolated from Viola yedoensis, as follows:

- Kalata B1: half-hemolysis concentration (HD_{50}) is 11.7 µM, 95% confidence interval 10.2–13.4 µM.

- Cycloviolacin Y4: HD_{50} is 9.3 µM, 95% confidence interval 7.7–11.1 µM.

- Cycloviolacin Y5: HD_{50} is 8.7 µM, 95% confidence interval 7.4–10.2 µM.

- Cycloviolacin Y1: within the tested concentration range, hemolysis is significantly lower than the above cyclic peptides and is the lowest among them.

- Melittin (positive control): HD_{50} is 0.94 µM, 95% confidence interval 0.9–0.97 µM, with hemolysis much higher than the tested cyclic peptides.

These data were obtained via hemolysis experiments using human type A red blood cells, with 1% Triton X-100 treatment as the maximum hemolysis control and PBS treatment as the minimum hemolysis control, and the hemolysis percentage was calculated.|||[Ref:18081258] HD50=8.7 uM against human type A red blood cells."	J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52. doi: 10.1021/np70393000000 ug. Epub 2007 Dec 15.||Ireland et al., 2008|||J Nat Prod. 2008 Jan;71(1):47-52.Biopolymers. 2008;90(1):51-60.Chembiochem. 2008 Aug 11;9(12):1939-45. doi: 10.1002/cbic.200800174.|||J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52.  Biopolymers. 2008;90(1):51-60.Chembiochem. 2008 Aug 11;9(12):1939-45. doi: 10.1002/cbic.200800174.|||https://pubmed.ncbi.nlm.nih.gov/18081258	30	
FPDB00084	AP01136|||AP01136|||Tricyclon A	GGTIFDCGESCFLGTCYTKGCSCGEWKLCYGTN	Anti-Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-E.coli, activity value is MIC = 160 uM||Anti-P. aeruginosa, activity value is MIC = 80 uM||Anti-S.aureus, activity value is MIC = 160 uM||Anti-C. albicans, activity value is MIC = 80 uM||Antibacterial	Australian flowers, Viola tricolor|||Australian flowers, Viola tricolor|||Viola odorata L. and Viola tricolor L	Beta	"Under specific hemolysis experimental conditions, after incubating 500 uM of tricyclon A with red blood cells at 37°C for 1 hour, the hemolysis rate was only 2%; under the same conditions, about 100 uM of kalata B1 resulted in a hemolysis rate of 50%. The HD50 of kalata B1 at 37°C is 100 uM, while tricyclon A exhibits very low hemolytic activity.|||The document mentions hemolytic-related data for tricyclon A and kalata B1, as follows:

- Tricyclon A: At a concentration of 500 µM, after incubation at 37°C for 1 hour, it only caused 2% hemolysis of red blood cells, indicating very low hemolytic activity.

- Kalata B1 (for comparison): Under the same experimental conditions, the half-hemolysis concentration (HD_{50}) is about 100 µM, meaning the concentration that causes 50% hemolysis of red blood cells is 100 µM.

These data were obtained through hemolysis experiments using human type A red blood cells as the experimental subject, with a 1% Triton X-100 treatment group as the maximum hemolysis control and a PBS treatment group as the minimum hemolysis control. The hemolysis percentage was calculated accordingly."	Structure. 2005 May;13(5):691-701|||Structure. 2005 May;13(5):691-701||Strömstedt et al., 2017|||Structure. 2005 May;13(5):691-701|||28669767	33	
FPDB00085	AP01137|||AP01137|||Siamycin I|||AP01137|||DRAMP18349|||Siamycin I	CLGVGSCNDFAGCGYAVVCFW	Anti-Gram+||Antiviral||Anti-HIV||Anti-Gram+ bacteria WT S. aureus ATCC29213, activity value is MIC = 3.7 uM||Anti-Staphylococcus aureus FDA209P JC-1, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus smith, activity value is MIC = 6.3 ug/ml||Anti-Staphylococcus aureus A15036, activity value is MIC = 3.1 ug/ml||Anti-Micrococcus luteus ATCC 9341, activity value is MIC = 1.6 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 1.6 ug/ml||Anti-Escherichia coli Juhl, activity value is MIC > 100 ug/ml||Anti-E. coli K12, activity value is MIC > 100 ug/ml||Anti-E. coli NIHJ JC-2, activity value is MIC > 100 ug/ml||Anti-K. pneumoniae ATCC 10031, activity value is MIC > 100 ug/ml||Anti-Citrobacter freundii GN 7391, activity value is MIC > 100 ug/ml||Anti-Salmonella typhi 901, activity value is MIC > 100 ug/ml||Anti-P. aeruginosa A9843A, activity value is MIC > 100 ug/ml||Antimicrobial	Streptomyces strain AA6532	Beta||Beta strand	No hemolysis information or data found in the reference(s) presented in this entry	J Antibiot (Tokyo). 1995 Dec;48(12):1515-7|||J Antibiot (Tokyo). 1995 Dec;48(12):1515-7|||8557614|||J Antibiot (Tokyo). 1995 Dec;48(12):1515-7|||J Antibiot (Tokyo). 1995 Dec;48(12):1515-7.|||8557614	21	
FPDB00086	AP01138|||AP01138|||DRAMP18347|||NP-06	CLGVGSCNDFAGCGYAIVCFW	Antiviral||Anti-HIV||Antimicrobial||Anti-HIV-1LAI, activity value is IC50 = 2.8 uM||Anti-HIV 2ROD, activity value is IC50 = 6 uM||Anti-HIV-1ERS104pre, activity value is IC50 = 1.3 uM	Streptomyces strain AA6532|||Streptomyces strain AA6532|||Streptomyces sp. No. 73264	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	Antimicrob Agents Chemother. 1995 Oct;39(10):2345-7|||Antimicrob Agents Chemother. 1995 Oct;39(10):2345-7|||Antimicrob Agents Chemother. 1995 Oct;39(10):2345-7.|||8619594	21	
FPDB00087	AP01184|||DRAMP31009|||AP01184|||Mucroporin-M1|||DRAMP31009	" 
LFRLIKSLIKRLVSAFK"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-Mucroporin-M1 is active against E. coli AB94012, activity value is MIC = 12.5 ug/ml||Anti-P. aeruginosa AB93066, activity value is MIC = 100 ug/ml||Anti-B. thuringiensis AB92037, activity value is MIC = 25 ug/ml||Anti-B. subtilis AB91021, activity value is MIC = 25 ug/ml||Anti-S. aureus AB94004, activity value is MIC = 5 ug/ml||Anti-clincal stain 1538 as well as HIV-1. Also active against measles McV, activity value is EC50 = 7.15 ug/ml||Anti-SARS-CoV, activity value is EC50 = 14.46 ug/ml||Anti-and influenza A virus H5N1, activity value is EC50 = 2.1 ug/ml||Anti-measles virus :inhibition of MeV infection in Vero cells, activity value is EC50 = 7.15 ug/ml||Anti-SARS-CoV :inhibition of SARS-CoV infection in MDCK cells, activity value is EC50 = 14.46 ug/ml||Anti-H5N1 :inhibition of H5N1 infection in MDCK cells, activity value is EC50 = 2.1 ug/ml||Anti-Measles virus, activity value is EC50 = 7.15 ug/ml||Anti-H5N1, activity value is EC50 = 2.1 ug/ml||Antimicrobial	Enterococcus faecium T8|||animal-derived, natural derivative|||Enterococcus faecium T8|||Synthetic construct(derived from Mucroporin)|||Enterococcus faecium T8|||Synthetic construct|||Synthetic construct(derived from Mucroporin)	N/A	BACTER	Appl Environ Microbiol. 2006 Jul;72(7):4761-6|||Appl Environ Microbiol. 2006 Jul;72(7):4761-6||Li et al., 2011|||Ref.21620914|||Appl Environ Microbiol. 2006 Jul;72(7):4761-6|||https://pubmed.ncbi.nlm.nih.gov/26492266,|||Peptides. 2011 Jul;32(7):1518-25.	17	
FPDB00088	AP01207|||AP01207|||Retrocyclin-1	GICRCICGRGICRCICGR	Antiviral||Anti-HIV||Anti-toxin||Antiviral ; HIV-1	mammal theta-defensin; Derived from a silent human gene (pre-stop), animal-derived, natural derivative|||mammal theta-defensin; Derived from a silent human gene (pre-stop), animal-derived, natural derivative|||Synthetic construct	Bridge	N/A	Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1813-8|||Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1813-8|||https://pubmed.ncbi.nlm.nih.gov/15210812	18	
FPDB00089	AP01208|||AP01208|||Retrocyclin-2	" 
GICRCICGRRICRCICGR"	Antiviral||Anti-HIV||Anti-toxin||RC2 is most active against primary isolates of HIV-1. The molecule can self associate in water in a concentration dependent manner.||Antiviral ; HIV-1	mammal theta-defensin; Derived from a silent human gene (pre-stop), animal-derived, natural derivative|||mammal theta-defensin; Derived from a silent human gene (pre-stop), animal-derived, natural derivative|||Synthetic construct	Beta	N/A	J Immunol. 2004 Jul 1;173(1):515-20|||J Immunol. 2004 Jul 1;173(1):515-20|||https://pubmed.ncbi.nlm.nih.gov/15210812	18	
FPDB00090	AP01223|||AP01223|||Ascaphin-8|||Ascaphin-8|||AP01223|||DRAMP01847|||AP01223|||DRAMP01847	"  
GFKDLLKGAAKALVKTVLF"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Enzyme inhibitor||Anticancer||Anti-E. coli, activity value is MIC = 6 uM||Anti-P. aeruginosa, activity value is MIC = 13 uM||Anti-E. cloacae, activity value is MIC = 6 uM||Anti-K. pneumoniae, activity value is MIC = 6 uM||Anti-S. epidermidis, activity value is MIC = 6 uM||Anti-Streptococcus Group B, activity value is MIC = 6 uM||Anti-E. faecalis, activity value is MIC = 50 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Anti-Escherichia coli, activity value is MIC = 6 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 50 uM||Anti-Enterobacter cloacae, activity value is MIC = 13 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 25 uM||Anti-Proteus mirabilis, activity value is MIC > 100 uM||Anti-S. epidermidis, activity value is MIC = 25 uM||Anti-E. faecalis, activity value is MIC > 100 uM||Anti-Streptococcus Group B, activity value is MIC = 13 uM||Anti-C. albicans, activity value is MIC = 100 uM||Anti-E. coli ATCC25922, activity value is MIC = 3 uM||Anti-S. aureus ATCC25923, activity value is MIC = 3 uM||Anti-E. coli ML35p, activity value is MIC = 1.6 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 3 uM||Anti-S. aureus multiresistant ATCCBAA-44, activity value is MIC = 3 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 12.5 uM||Anti-A549, activity value is IC50 = 33.79 uM||Anti-C4-2B, activity value is IC50 = 42.91 uM||Anti-HEK293T, activity value is IC50 = 53.67 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Ascaphus truei [Coastal tailed frog]|||Ascaphus truei (Coastal tailed frog)|||Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Ascaphus truei (Coastal tailed frog)	Helix	"Free acid HC50>200  Amidated HC50=55|||Endogenous peptides:

ascaphin-1: Half-maximal hemolytic concentration (HC_{50}) for human red blood cells >200 μM.

ascaphin-3: HC_{50} >200 μM.

ascaphin-7: HC_{50} >200 μM.

ascaphin-8: HC_{50} is 50 μM.

Synthetic peptides:

ascaphin-1 (free acid form): HC_{50} >200 μM; amidated form: HC_{50} >200 μM.

ascaphin-5 (free acid form): HC_{50} >200 μM.

ascaphin-8 (amidated form): HC_{50} is 55 μM.

The above results were obtained through hemolysis experiments. In the experiments, peptides at different concentrations were incubated with washed human red blood cells for 1 hour, and the degree of hemolysis was measured by absorbance at 450 nm. The 1% Tween 20 treated group was used as the 100% hemolysis control, and HC_{50} was defined as the peptide concentration producing 50% hemolysis.|||Ascaphin-1: HC₅₀ > 200 uM.
Ascaphin-3: HC₅₀ > 200 uM.

Ascaphin-7: HC₅₀ > 200 uM.

Ascaphin-8:

Endogenous Ascaphin-8: HC₅₀ = 50 uM.

Synthetic amidated Ascaphin-8: HC₅₀ = 55 uM.

Ascaphin-5: HC₅₀ > 200 uM.|||Human erythrocytes ( HC50 = 50 uM ); Refer PubMed ID 23094651: Rat RBCs [HC50 = 115 uM], PubMed ID 33932712: Rabbit RBC [HC50 = >100 miroM]|||Human erythrocytes ( HC50 = 50 uM ); Refer PubMed ID 23094651: Rat RBCs [HC50 = 115 uM], PubMed ID 33932712: Rabbit RBC [HC50 = >100 miroM]|||The therapeutic potential of ascaphin-8 as an antiinfective agent is limited by its moderately high haemolytic activity (HC50 ¼ 55 lM) In contrast, ascaphin-1 and ascaphin-5, although displaying high potencies only against Gram-negative bacteria, have very low haemolytic activities (HC50 >200 lM) compared with many other frog skin peptides. By way of comparison, the HC50 values of brevinin-1E from Rana esculenta [22] and temporin L from Rana temporaria [23] are less than 2 lM.|||[Ref.15207717]HC50=50 uM against human erythrocytes|||The document mentions the hemolytic values of various ascaphin peptides (expressed as HC_{50}, which is the peptide concentration that causes 50% hemolysis), as follows:

Hemolytic values of endogenous peptides (Table 1)

- Ascaphin-1: HC_{50} > 200 μM

- Ascaphin-3: HC_{50} > 200 μM

- Ascaphin-7: HC_{50} > 200 μM

- Ascaphin-8: HC_{50} = 50 μM

Hemolytic values of synthetic peptides (Table 2)

- Ascaphin-1 (free acid form): HC_{50} > 200 μM

- Ascaphin-1 (amidated form): HC_{50} > 200 μM

- Ascaphin-5 (free acid form): HC_{50} > 200 μM

- Ascaphin-8 (amidated form): HC_{50} = 55 μM|||[Ref.15207717]HC50=50 uM against human erythrocytes|||hemolytic HC50 50 uM. TC50 2.9 uM in CEM-SS cells(Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346)."	"Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. doi: 10.1016/j.bbrc.2004.05.141.||Menousek J et al 2012 Int J Antimicrob Agents 39:402|||Comparative Study Biochem Biophys Res Commun
. 2004 Jul 16;320(1):170-5. doi: 10.1016/j.bbrc.2004.05.141.|||2004 Jul 16;320(1):170-5. doi: 10.1016/j.bbrc.2004.05.141.||Menousek J et al 2012 Int J Antimicrob Agents 39:402|||15207717, 33932712, 23094651||Refer PubMed ID 23094651|||15207717, 33932712, 23094651||Refer PubMed ID 23094651||Refer PubMed ID 33932712|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed||Menousek J et al 2012 Int J Antimicrob Agents 39:402|||Ref.15207717|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175."	19	
FPDB00091	AP01269|||AP01269|||Melectin	" 
GFLSILKKVLPKVMAHMK"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-MRSA||Anti-B. subtilis, activity value is MIC = 0.8 uM||Anti-S. aureus MRSA, activity value is MIC = 6.8||Anti-E. coli, activity value is MIC = 2||Anti-and P. aeruginosa, activity value is MIC = 18.5 uM||Anti-the peptide was found to inhibit Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 4.34 uM||Anti-B.subtilis, activity value is MIC = 0.8 uM||Anti-S.aureus, activity value is MIC = 6.8 uM||Anti-E.coli, activity value is MIC = 2 uM||Anti-P.aeruginosa, activity value is MIC = 18.5 uM	the Cleptoparasitic bee, Melecta albifrons|||the Cleptoparasitic bee, Melecta albifrons|||Melecta albifrons [Cuckoo bee]	Helix	"MEP: The half-maximal hemolytic concentration (LC_{50}) on rat red blood cells is >100 µM, indicating low hemolytic activity. 

MEP-1: LC_{50} is 27.3 µM.

MEP-2: LC_{50} is 22.9 µM.

MEP-3: LC_{50} is 29.7 µM.

MEP-4: LC_{50} is 41.4 µM.

MEP-5, MEP-6, MEP-7, MEP-8, MEP-9, MEP-10: LC_{50} are all >100 µM, showing no significant hemolytic activity.

The above results were obtained through hemolysis experiments, in which peptides at different concentrations were incubated with rat red blood cells at 37°C for 1 hour. Hemolysis was measured by absorbance at 540 nm, with a 0.2% Triton X-100 treated group as the 100% hemolysis control. LC_{50} refers to the peptide concentration that produces 50% hemolysis. The results indicate that the original MEP has the lowest hemolytic activity, whereas analogs in which Pro11 was replaced or deleted (MEP-1 to MEP-4) show significantly increased hemolytic activity.|||The document mentions that the hemolytic concentration (LC₅₀) of natural bee venom peptide Melectin (MEP) is greater than 100 μM, showing extremely low hemolytic activity. In contrast, the hemolytic values of its analogs (such as MEP-1, MEP-2, etc.) range from 22.9 μM to 41.4 μM.|||The hemolytic value LC_{50} of MEP is > 100 μM; the hemolytic value LC_{50} of MEP-1 is 27.3 μM; the hemolytic value LC_{50} of MEP-2 is 22.9 μM; the hemolytic value LC_{50} of MEP-3 is 29.7 μM; the hemolytic value LC_{50} of MEP-4 is 41.4 μM; the hemolytic value LC_{50} of MEP-5 is > 100 μM; the hemolytic value LC_{50} of MEP-6 is > 100 μM; the hemolytic value LC_{50} of MEP-7 is > 100 μM; the hemolytic value LC_{50} of MEP-8 is > 100 μM; the hemolytic value LC_{50} of MEP-9 is > 100 μM; the hemolytic value LC_{50} of MEP-10 is > 100 μM."	"Chembiochem. 2008 Nov 24;9(17):2815-21. PubMed|||Chembiochem. 2008 Nov 24;9(17):2815-21. doi: 10.1002/cbic.200800476.||Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346|||Chembiochem
. 2008 Nov 24;9(17):2815-21. doi: 10.1002/cbic.200800476.|||2008 Nov 24;9(17):2815-21. doi: 10.1002/cbic.200800476.||Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346|||18942691"	18	
FPDB00092	AP01271|||DRAMP01225|||AP01271|||DRAMP01225	GIFPKIIGKGIVNGIKSLAKGVGMKVFKAGLNNIGNTGCNNRDEC	Anti-Gram-||Antiviral||Anti-HIV||Anti-E. coli, activity value is MIC = 6 uM||Anti-but not Staph (S.aureus or C.albicans, activity value is MIC > 200 uM||Antimicrobial||Antibacterial	the crawfish frog, Rana areolata, North America|||the crawfish frog, Rana areolata, North America|||Amolops jingdongensis (Chinese torrent frog)|||the crawfish frog, Rana areolata, North America|||Rana areolata (North American crawfish frog)	N/A	"The document mentions the hemolytic values of various peptides, with the following specific information:
palustrin-3AR: hemolytic concentration (HC₅₀) is 200 µM.
esculentin-1ARa: HC₅₀ is 180 µM.
esculentin-1ARb: HC₅₀ is 120 µM.
ranatuerin-2ARa: HC₅₀ is 100 µM.
ranatuerin-2ARb: HC₅₀ is 150 µM.
temporin-1AR: HC₅₀ is 210 µM.
palustrin-2AR: no significant hemolysis observed at a concentration of 300 µM.|||The hemolytic values of various antimicrobial peptides mentioned in the document (expressed as HC_{50}, the peptide concentration that causes 50% hemolysis of human red blood cells) are as follows:

- Palustrin-3AR: HC_{50} = 200 μM

- Esculentin-1ARa: HC_{50} = 180 μM

- Esculentin-1ARb: HC_{50} = 120 μM

- Ranatuerin-2ARa: HC_{50} = 100 μM

- Ranatuerin-2ARb: HC_{50} = 150 μM

- Palustrin-2AR: HC_{50} > 300 μM

- Temporin-1AR: HC_{50} = 210 μM|||[Ref:12429503] HC50=200 uM against human erythrocytes"	Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. PubMed|||Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. doi: 10.1016/s1570-9639(02)00432-6.|||2002 Nov 19;1601(1):55-63. doi: 10.1016/s1570-9639(02)00432-6.|||Biochimie. 2012 Feb;94(2):328-334.|||Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. PubMed|||Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63.	45	
FPDB00093	AP01273|||DRAMP01475	GLFPKFNKKKVKTGIFDIIKTVGKEAGMDVLRTGIDVIGCKIKGEC	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-E. coli, activity value is MIC = 3 uM||Anti-but not C.albicans, activity value is MIC > 200 uM	the crawfish frog, Rana areolata, North America|||the crawfish frog, Rana areolata, North America|||Rana areolata (crawfish frog)	N/A	"The document mentions the hemolytic values of various peptides, with the following specific information:
palustrin-3AR: hemolytic concentration (HC₅₀) is 200 µM.
esculentin-1ARa: HC₅₀ is 180 µM.
esculentin-1ARb: HC₅₀ is 120 µM.
ranatuerin-2ARa: HC₅₀ is 100 µM.
ranatuerin-2ARb: HC₅₀ is 150 µM.
temporin-1AR: HC₅₀ is 210 µM.
palustrin-2AR: no significant hemolysis observed at a concentration of 300 µM.|||[Ref:12429503] HC50=120 uM against human erythrocytes|||The hemolytic values of various antimicrobial peptides mentioned in the document (expressed as HC_{50}, the peptide concentration that causes 50% hemolysis of human red blood cells) are as follows:

- Palustrin-3AR: HC_{50} = 200 μM

- Esculentin-1ARa: HC_{50} = 180 μM

- Esculentin-1ARb: HC_{50} = 120 μM

- Ranatuerin-2ARa: HC_{50} = 100 μM

- Ranatuerin-2ARb: HC_{50} = 150 μM

- Palustrin-2AR: HC_{50} > 300 μM

- Temporin-1AR: HC_{50} = 210 μM"	"Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. PubMed|||Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. doi: 10.1016/s1570-9639(02)00432-6.|||2002 Nov 19;1601(1):55-63. doi: 10.1016/s1570-9639(02)00432-6.|||[Ref.12429503]Gram-negative bacterium: Escherichia coli (MIC=3 uM);
Gram-positive bacterium: Staphylococcus aureus (MIC=60 uM)."	46	
FPDB00094	AP01348|||AP01348|||Temporin-LTc|||DRAMP01784|||AP01348|||DRAMP01784	" 
SLSRFLSFLKIVYPPAF"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 50 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 50 ug/ml||Anti-Pseudomonas fluorescens ATCC13525, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 50 ug/ml||Anti-Pseudomonas fluorescens, activity value is MIC = 100 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae), China, Asia|||Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae), China, Asia|||Hylarana latouchii|||Hylarana latouchii (broad-folded frog)|||Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae), China, Asia|||Hylarana latouchii (broad-folded frog)	N/A	"The document mentions the following values related to hemolysis:

brevinin-1LTa: The median lethal concentration (LD₅₀) for rabbit red blood cells is 1.5 µg/ml, showing strong hemolytic activity.
temporin-LTa: The median lethal concentration (LD₅₀) for rabbit red blood cells is 9 µg/ml, with relatively weak hemolytic activity.
temporin-LTb and temporin-LTc: No significant hemolytic activity was detected at concentrations up to 200 µg/ml.|||Rabbit erythrocytes ( LD50 > 200 ug/ml )|||No hemolysis information or data found in the reference(s) presented in this entry"	Peptides. 2009 Feb;30(2):273-82. Pub-Med.|||Peptides. 2009 Feb;30(2):273-82. doi: 10.1016/j.peptides.2008.10.016. Epub 2008 Nov 5.|||2009 Feb;30(2):273-82. doi: 10.1016/j.peptides.2008.10.016. Epub 2008 Nov 5.|||19022312|||Peptides. 2009 Feb;30(2):273-82. Pub-Med.|||Peptides. 2009 Feb;30(2):273-282.	17	
FPDB00095	AP01434|||AP01434|||Temporin-PTa|||DRAMP01802	FFGSVLKLIPKIL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-MRSA||Antibiofilm||Anti-the natural form was not evaluated due to a low amount of the peptide. A synthetic peptide was found to be active. The L and D-forms of the peptide showed identical antibacterial activity against E. coli, activity value is MIC = 25 uM||Anti-B. subtilis, activity value is MIC = 6.25 uM||Anti-and S. aureus USA300 MRSA, activity value is MIC = 3.1 uM||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	Hylarana picturata, Asia|||Hylarana picturata, Asi|||Rana picturata [Malaysian fire frog]|||Rana picturata (Malaysian fire frog) (Hylarana picturata)	Helix	N/A	"Toxicon. 2008 Sep 1;52(3):465-73. Pub-Med.|||Toxicon. 2008 Sep 1;52(3):465-73. doi: 10.1016/j.toxicon.2008.06.017. Epub 2008 Jun 25.|||Toxicon
. 2008 Sep 1;52(3):465-73. doi: 10.1016/j.toxicon.2008.06.017. Epub 2008 Jun 25.|||2008 Sep 1;52(3):465-73. doi: 10.1016/j.toxicon.2008.06.017. Epub 2008 Jun 25.|||18621071|||Toxicon. 2008 Sep 1;52(3):465-473."	13	
FPDB00096	AP01580|||AP01580|||Elafin	AQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ	Anti-Gram+ & Gram-||Antiviral||Antifungal||Antiparasitic||Anti-HIV||Enzyme inhibitor||Antimalarial||active against P. aeruginosa PAO1 and S. aureus C1705. Active against HIV-1 and HSV-2 (Drannik AG||et al 2013). The anti-HIV activity of Elafin is 130 times more potent than its precursor serine antiprotease trappin-2 (Drannik AG||et al 2012).||Antibacterial ; S. aureus||P. aeruginosa	gammadelta T cells, keratinocytes, epithelial cells, skin, Homo sapiens|||skin, Homo sapiens|||Homo sapiens [Human]	Beta	no hemolytic activity	FEBS Lett. 1999 Jun 11;452(3):309-13. doi: 10.1016/s0014-5793(99)00670-5. PubMed|||FEBS Lett. 1999 Jun 11;452(3):309-13. doi: 10.1016/s0014-5793(99)00670-5.|||Scand J Immunol. 2009 Dec;70(6):547-52|||16336202	57	
FPDB00097	AP01654|||AP01654|||Caerin-1.19|||AP01654|||DRAMP01586	GLFKVLGSVAKHLLPHVAPIIAEKL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	skin dorsal glands, Australian dainty green tree frog, Litoria gracilenta|||skin dorsal glands, Australian dainty green tree frog, Litoria gracilenta|||Litoria gracilenta [Dainty green tree frog]|||skin dorsal glands, Australian dainty green tree frog, Litoria gracilenta|||Litoria gracilenta (Dainty green tree frog)	N/A	Bacillus cereus ( MIC = 50 ug/ml), Leuconostoc lactis ( MIC = 3 ug/ml), Listeria innocua ( MIC = 12 ug/ml), Micrococcus luteus ( MIC = 25 ug/ml), Staphylococcus aureus Strain ATCC 25923 ( MIC = 12 ug/ml), Staphylococcus aureus Strain ATCC 29213 ( MIC = 12 ug/ml), Staphylococcus epidermidis ( MIC = 12 ug/ml), Streptococcus uberis ( MIC = 25 ug/ml), Pasteurella multocida ( MIC = 50 ug/ml)|||No hemolysis information or data found in the reference(s) presented in this entry	Toxicon. 2006 May;47(6):664-75|||Toxicon. 2006 May;47(6):664-75|||16554081|||Toxicon. 2006 May;47(6):664-75|||Peptides. 2015 Sep;71:296-303.Toxicon. 2006 May;47(6):664-675.	25	
FPDB00098	AP01672|||AP01627|||AP01672|||RC-101	" 
GICRCICGKGICRCICGR"	Anti-Gram+||Antiviral||Anti-HIV||Anti-MRSA||Anti-toxin||Antibiofilm||inhibit S. aureus USA300||viruses HIV-1||SARS-Cov-2||influenza.||Antibacterial	amino acid substitution, mammal theta-defensin analog, animal-derived, natural derivative|||amino acid substitution, mammal theta-defensin analog, animal-derived, natural derivative|||Synthetic construct	Bridge	N/A	"RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. PubMed.|||2004 Nov;20(11):1157-65. doi: 10.1089/aid.2004.20.1157.||Lamers et al., 2011|||AIDS Res Hum Retroviruses.2004 Nov;20(11):1157-65. doi: 10.1089/aid.2004.20.1157.||Lamers et al., 2011|||AIDS Res Hum Retroviruses
. 2004 Nov;20(11):1157-65. doi: 10.1089/aid.2004.20.1157.|||AIDS Res Hum Retroviruses
. 2004 Nov;20(11):1157-65. doi: 10.1089/aid.2004.20.1157.|||16790431"	18	
FPDB00099	AP01978|||AP01978|||BmKn2|||CAMPSQ14088|||CAMPSQ14139|||CAMPSQ14397	" 
FIGAIARLLSKIF"	"Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-MRSA||Hemolytic||Antibiofilm||Wound healing||Anticancer
Crucial residues:||Anticancer||Anti-Gram+ bacteria S. aureus AB94004 or ATCC 25923 or MRSA P1386, activity value is MIC = 0.6 ug/ml||Anti-M. luteus AB93113, activity value is MIC = 8 ug/ml||Anti-B. subtilis AB91021, activity value is MIC = 5 ug/ml||Anti-B. thuringiensis AB92037, activity value is MIC = 12.5 ug/ml||Anti-S. epidermidis, activity value is MIC = 2.5||Anti-E. faecalis, activity value is MIC = 10 ug/ml||Anti-E. faecium, activity value is MIC = 10 ug/ml||Anti-E. coli, activity value is MIC = 1.5 ug/ml||Anti-P. aeruginosa AB93066 and 5 more strains, activity value is MIC = 21.3||Anti-S.aureus, activity value is MIC = 0.6 ug/ml||Anti-M.luteus, activity value is MIC = 8 ug/ml||Anti-B.subtilis, activity value is MIC = 5 ug/ml||Anti-E.coli, activity value is MIC = 1.5 ug/ml||Anti-P.aeruginosa, activity value is MIC = 21.3 ug/ml||Anti-Staphylococcus aureus AB94004, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.25 ug/ml||Anti-Bacillus subtilis AB91021, activity value is MIC = 12.5 ug/ml||Anti-Bacillus thuringiensis AB92037, activity value is MIC = 12.5 ug/ml||Anti-Micrococcus luteus AB93113, activity value is MIC = 6.25 ug/ml||Anti-Pseudomonas aeruginosa AB93066, activity value is MIC = 50 ug/ml||Anti-S. aureus ATCC29213, activity value is MIC = 10 ug/ml||M. abscessus ATCC19977 (MIC= >400 ug/ml)"	venom, Buthus martensii Karsch|||venom, Buthus martensii Karsch|||venom, Buthus martensii Karsch, China, Asia|||Mesobuthus martensii [Manchurian scorpion]|||Mesobuthus martensii|||Synthetic construct	Helix	venom, Buthus martensii Karsch|||Human RBCs (< 40% percent hemolysis at 100 ug/ml)	"Peptides. 2004 Feb;25(2):143-50.PubMed|||Peptides. 2004 Feb;25(2):143-50.doi: 10.1016/j.peptides.2003.12.003.||Arpornsuwan et al., 2014||Mangmee et al. 2021|||Peptides
. 2004 Feb;25(2):143-50. doi: 10.1016/j.peptides.2003.12.003.|||Peptides. 2004 Feb;25(2):143-50. doi: 10.1016/j.peptides.2003.12.003.||Arpornsuwan et al., 2014||Mangmee et al. 2021|||15062994|||22792229|||34335511|||34361810|||34780520"	13	
FPDB00100	AP02010|||AP02010|||Caerin 1.20|||DRAMP30311|||AP02010|||DRAMP30311	GLFGILGSVAKHVLPHVIPVVAEHL	Anti-Gram+||Antiviral||Anti-HIV||Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.faecalis, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 25 uM||Anti-L. innocua, activity value is MIC = 25 ug/ml||Anti-M. luteus, activity value is MIC = 20 ug/ml||Anti-or 29213, activity value is MIC = 25||Anti-S. epidermidis, activity value is MIC = 25 ug/ml||Anti-S. uberis, activity value is MIC = 50 ug/ml||Anti-E.clocae, activity value is MIC > 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-and P.multocida, activity value is MIC > 100 ug/ml||Antibacterial||Anti-Human immunodeficiency virus : inhibition of HIV Pseudovirus infection in CD4+ T cells, activity value is IC50 = 7 uM	the skin secretions, hybrid between female Litoria splendida and male Litoria caerulea , Australia|||Hybrid between female Litoria splendida and male Litoria caerulea|||Litoria caerulea/Litoria splendida|||the skin secretions, hybrid between female Litoria splendida and male Litoria caerulea , Australia|||Litoria caerulea/Litoria splendida	N/A	the skin secretions, hybrid between female Litoria splendida and male Litoria caerulea , Australia||At a concentration of 400 μM, the hemolysis rate is < 10%.	FEBS J. 2006 Aug;273(15):3511-9.PubMed|||FEBS J. 2006 Aug;273(15):3511-9.doi: 10.1111/j.1742-4658.2006.05358.x. Epub 2006 Jul 5.|||FEBS J. 2006 Aug;273(15):3511-9. doi: 10.1111/j.1742-4658.2006.05358.x. Epub 2006 Jul 5.|||16824041|||Ref.26026377|||FEBS J. 2006 Aug;273(15):3511-9.PubMed|||Peptides. 2015 Sep;71:296-303.Antibiotics (Basel). 2020 Sep 30;9(10):661.||Ref.26026377	25	
FPDB00101	AP02034|||DRAMP00264|||Antifungal protein from coconut|||DRAMP00264|||AP02034|||CAMPSQ771|||DRAMP00264	EQCREEEDDR	Antiviral||Antifungal||Anti-HIV||Antimicrobial||Antibacterial||Antifungal ; N.A	Cocos nucifera|||Cocos nucifera|||Cocos nucifera [Coconut]	N/A	No hemolysis information or data found in the reference(s) presented in this entry	Peptides. 2005 Dec;26(12):2392-6. PubMed|||Peptides. 2005 Dec;26(12):2392-2396.|||https://pubmed.ncbi.nlm.nih.gov/16308082|||Peptides. 2005 Dec;26(12):2392-2396.|||Peptides. 2005 Dec;26(12):2392-6. PubMed|||16308082|||Peptides. 2005 Dec;26(12):2392-2396.	10	
FPDB00102	AP02075|||AP02075|||CCL20|||DRAMP03555	" 
SNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Anti-HIV||Chemotactic||Antibiofilm||Anti-Gram- P. aeruginosa PA01, activity value is LD50 = 1.1 ug/ml||Anti-M. catarrhalis ATCC43627, activity value is LD50 = 0.9 ug/ml||Anti-S. pyogenes ATCC14289, activity value is LD50 = 0.2 ug/ml||Anti-E. faecium 1438, activity value is LD50 = 4.5 ug/ml||Anti-C. albicans 90028, activity value is LD50 = 25 ug/ml||Anti-and C. neoforman 96-1043, activity value is LD50 = 80 ug/ml||Anti-S. coag. neg. spp, activity value is MIC = 1.58 uM||Anti-Propionibacterium spp, activity value is MIC = 5.23 uM||Anti-S. aureus, activity value is MIC = 5.54 uM||Anti-and C. albicans, activity value is MIC = 0.09 uM||Antibacterial ; Escherichia coli ATCC25922||Staphylococcus aureus ATCC29213||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	Skin, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)	Combine Helix and Beta structure	Skin, Homo sapiens||At a concentration of 20 μM, the hemolysis rate is < 10%.	"J Leukoc Biol. 2003 Sep;74(3):448-55. Pub-Med. GenBank:NP_001123518.1.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.||Ramamourthy et al., 2019|||https://pubmed.ncbi.nlm.nih.gov/12949249|||J Leukoc Biol
. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||J Biol Chem. 2002 Oct 4;277(40):37647-54."	69	
FPDB00103	AP02082|||AP02082|||CXCL12	KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK	Anti-Gram+ & Gram-||Anti-HIV||Chemotactic||At 10 ug/ml||it killed 86% E. coli and 59% S. aureus.The CXCR4 chemokine receptor is excluisvely activated by CXCL12. This activation promotes chemotaxis in leukocytes||stem cells||and central nervous systems. CXCR4 is also involved in cancer metastasis and HIV replication (co-receptor for infection).||Antibacterial ; Escherichia coli ATCC25922||Staphylococcus aureus ATCC29213	Homo sapiens|||Homo sapiens [Human]	Combine Helix and Beta structure	Homo sapiens	J Leukoc Biol. 2003 Sep;74(3):448-55. Pub-Med. GenBank:O62657.1.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||https://pubmed.ncbi.nlm.nih.gov/12949249	68	
FPDB00104	AP02084|||AP02084|||XCL1	VGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG	Anti-Gram+ & Gram-||Anti-HIV||Chemotactic||At 10 ug/ml||it killed 100% E. coli and 47% S. aureus. Importantly||this CD8+ T cells derived chemokine inhibits a broad spectrum of HIV isolates.||Antibacterial ; Escherichia coli ATCC25922||Staphylococcus aureus ATCC29213	CD8+ T cells, Homo sapiens|||Homo sapiens [Human]	Beta	CD8+ T cells, Homo sapiens||At a concentration of 10 μM, the hemolysis rate is < 5%.	J Leukoc Biol. 2003 Sep;74(3):448-55. Pub-Med. GenBank:NP_002986.1|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||12949249	93	
FPDB00105	AP02095	SGKSFKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKR	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-inflammatory||Enzyme inhibitor	tears, saliva, airway, gastrointestines, genital tracts, Homo sapiens	Beta	N/A	J Bacteriol. 1989 Apr;171(4):2166-72. Pub-Med. GenBank:CAA28187.1	88	
FPDB00106	AP02130	" 
GSGPTYCWNEANNPGGPNRCSNNKQCDGARTCSSSGFCQGTSRKPDPGPKGPTYCWDEAKNPGGPNRCSNSKQCDGARTCSSSGFCQ"	Antiviral||Anti-HIV	cyanobacterium, Scytonema varium	Combine Helix and Beta structure	N/A	Biochemistry. 2003 Mar 11;42(9):2578-84.Pub-Med.	87	
FPDB00107	AP02131	LGKFSQTCYNSAIQGSVLTSTCERTNGGYNTSSIDLNSVIENVDGSLKWQPSNFIETCRNTQLAGSSELAAECKTRAQQFVSTKINLDDHIAN	Antiviral||Anti-HIV	cyanobacterium (blue-green alga), Nostoc ellipsosporum	Beta	N/A	Antimicrob Agents Chemother. 1997 Jul;41(7):1521-30.Pub-Med.	93	
FPDB00108	AP02132	MASYKVNIPAGPLWSNAEAQQVGPKIAAAHQGNFTGQWTTVVESAMSVVEVELQVENTGIHEFKTDVLAGPLWSNDEAQKLGPQIAASY	Antiviral||Anti-HIV	blue-green algae, Microcystis viridis	Combine Helix and Beta structure	N/A	Biochem Biophys Res Commun. 1999 Nov 30;265(3):703-8.Pub-Med.	89	
FPDB00109	AP02133	" 
SLTHRKFGGSGGSPFSGLSSIAVRSGSYLDAIIIDGVHHGGSGGNLSPTFTFGSGEYISNMTIRSGDYIDNISFETNMGRRFGPYGGSGGSAN"	Antiviral||Anti-HIV	the red alga Griffithsia sp	Beta	N/A	J Biol Chem. 2005 Mar 11;280(10):9345-53.Pub-Med.	93	
FPDB00110	AP02526|||DRAMP18204|||AP02526|||DRAMP18204	" 
SNASVWECCSTGSWVPFTCC"	Antiviral||Anti-HIV||Anti-It inhibited HIV-1, activity value is IC50 = 1.7 uM||Anti-HIV-2, activity value is IC50 = 1.9 uM||Anti-HSV-1, activity value is IC50 = 0.6 uM||Anti-HSV-2, activity value is IC50 = 0.3 uM||Anti-including dengue virus DENV-2, activity value is IC50 = 0.55 uM||activity value is IC50 = 0.51||Anti-West Nile virus (WNV, activity value is IC50 = 0.2 uM||Anti-hepatitis C virus (HCV, activity value is IC50 = 1.1 uM||activity value is IC50 = 2.2 uM||Antimicrobial||Anti-HSV	Actinomadura namibiensis DSM 6313	N/A	No hemolysis information or data found in the reference(s) presented in this entry	PLoS One. 2013 May 28;8(5):e64010. PubMed|||PLoS One. 2013 May 28;8(5):e64010. doi: 10.1371/journal.pone.0064010. Print 2013.|||PLoS One. 2013 May 28;8(5):e64010.|||PLoS One. 2013 May 28;8(5):e64010. PubMed|||PLoS One. 2013 May 28;8(5):e64010.	20	
FPDB00111	AP03795|||1528|||1534|||1540|||AP03795|||Ll-37|||DRAMP03075|||DRAMP03575	" 
FKRIVQRIKDFLR"	Anti-Gram+ & Gram-||Antiviral||Antiparasitic||Anti-HIV||Synergistic AMPs||LC50=60 uM||LC50=57 uM||LC50=55 uM||Anti-E. coli KCTC 1682, activity value is MIC = 16 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 32 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 16 uM||Anti-B. subtilis KCTC 3068, activity value is MIC = 4 uM||Anti-S. epidermidis KCTC 1917, activity value is MIC = 16 uM||Anti-and S. aureus KCTC1621, activity value is MIC = 16 uM||Anti-E. coli K12, activity value is MIC = 40 uM||Anti-Escherichia coli K12, activity value is MIC = 40 uM||Anti-Drug-sensitive KB cancer cells . Gram-positive bacteria: Staphylococcus aureus ATCC 29213, activity value is MIC = 16 uM||Anti-S. faecalis ATCC 29212, activity value is MIC = 32 uM||Anti-Bacillus subtilis CMCC 63501, activity value is MIC = 16 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 8 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 16 uM||Anti-Escherichia coli UB 1005, activity value is MIC = 16 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 16 uM||Anti-Salmonella typhimurium ATCC 14028, activity value is MIC = 32 uM||Anti-Salmonella typhimurium ATCC 7731, activity value is MIC = 16 uM||Anti-Escherichia coli, activity value is MIC = 5 uM||Anti-Drug-sensitive KB cancer cells .## Gram-positive bacteria: Staphylococcus aureus ATCC 29213, activity value is MIC = 16 uM||Anti-##Gram-negative bacteria: Escherichia coli ATCC 25922, activity value is MIC = 16 uM||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 5 uM	NMR-discovered, Sequence truncation; TOCSY-trim, human cathelicidin analog, animal-derived, natural derivative|||NMR-discovered, Sequence truncation; TOCSY-trim, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Homo sapiens|||Homo sapiens	Helix||Alpha helix##Random coil	No hemolytic activity (0% hemolysis at 100 µM)|||human RBC: HC50 > 256 uM, not hemo.lytic.|||[Ref.28161291] HC50>256 uM against human red blood cells. [Ref.23894079] MHC10=160 uM against human red blood cells	J Am Chem Soc. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875, PubMed|||J Am Chem Soc. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875,||Rajasekaran et al., 2017|||J Am Chem Soc. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875, PubMed||Rajasekaran et al., 2017|||16637646|||Ref.16637646||Ref.28178190||Ref.23894079|||J Am Chem Soc. 2006 May 3;128(17):5776-5785.##Int J Mol Sci. 2017 Feb 6;18(2). pii: E339. ##Biochim Biophys Acta Biomembr. 2017 May;1859(5):722-733.##ChemMedChem. 2013 Oct;8(10):1638-42.||Ref.16637646||Ref.28178190||Ref.23894079	13	L
FPDB00112	AP03807|||AP03807|||GI-20|||DRAMP31340|||AP03807|||DRAMP31340	" 
GIKEFKRIVQRIKDFLRNLV"	Anti-Gram+ & Gram-||Antiviral||Spermicidal||Anti-HIV||Anti-It inhibits HIV-1. Active against E. faecium V284-17, activity value is MIC = 2 uM||Anti-S. aureus USA300, activity value is MIC = 2||Anti-K-pneumoniae E406-17, activity value is MIC > 32 uM||Anti-P-aeruginosa E411-17, activity value is MIC > 32 uM||Anti-and E. coli E423-17, activity value is MIC = 32 uM||Anti-MRSA||Antibiofilm||Anti-E. faecium V284-17, activity value is MIC = 2 uM||Anti-A. baumannii B28-16, activity value is MIC = 8 uM||Anti-E. coli E423-17, activity value is MIC = 32 uM||Antimicrobial	Derivative of LL-37; Sequence truncation. human cathelicidin analog, animal-derived, natural derivative|||Derivative of LL-37; Sequence truncation. human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from human cathelicidin LL-37)|||Derivative of LL-37; Sequence truncation. human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from human cathelicidin LL-37)	Helix	No hemolytic activity (0% hemolysis at 100 µM)|||human RBC: HC50 ~150 uM, some hemolytic.|||Human RBC (62% hemolysis at 200 uM)	"Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.||Zhang et al., 2021|||Antimicrob Agents Chemother
. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. Epub 2008 Jun 30.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed||Zhang et al., 2021|||34959645|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40."	20	
FPDB00113	AP03814|||Tat	" 
YGRKKRRQRRRD"	Anti-Gram+||Antiviral||Anti-HIV||active against MRSA demonstrated in human HeLa cells in vitro. D-form is more effective due to resistance to proteases (D>L). A similar sequence TAT(48-57) (seq: GRKKRRQRRR) inhibits HIV-1  .||Antifungal	designed, man-made sequences|||Synthetic construct	N/A	"Human erythrocytes (0% Hemolysis at 25 uM|||The document mentions Tat (47-58) and its enantiomer's hemolytic-related data, specifically as follows:

- L-Tat (47-58): At concentrations ranging from 1.25-20 µM, it shows no hemolytic activity against human red blood cells (RBCs), with a hemolysis rate of 0%.

- D-Tat (47-58): Within the same concentration range (1.25-20 µM), it also shows no hemolytic activity against human red blood cells, with a hemolysis rate of 0%.

- Control (Melittin, bee venom peptide): Used as a positive control, with a hemolysis rate of 100% at 20 µM, 95.4% at 10 µM, 61.1% at 5 µM, 34.5% at 2.5 µM, and 0% at 1.25 µM.

Note: In the hemolysis assay, the PBS-treated group was used as the 0% hemolysis control, and the 0.1% Triton X-100-treated group was used as the 100% hemolysis control. Hemolysis rates were calculated by measuring the absorbance at 414 nm."	J Microbiol Biotechnol. 2008 May;18(5):990-6. PubMed|||J Microbiol Biotechnol. 2008 May;18(5):990-6.||Keogan et al., 2012|||J Microbiol Biotechnol. 2008 May;18(5):990-6. PubMed||Keogan et al., 2012|||16678135	12	
FPDB00114	AP03839|||DRAMP31336|||AP03839|||LL-37|||DRAMP31336	" 
SKEKIGKEFKRIVQRIKDFLR"	Antiviral||Anti-HIV||Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 10.8 uM||Antimicrobial||Antiviral ; HIV[IC50 REP = 10.8 uM]	Sequence truncation, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from human cathelicidin LL-37)|||Sequence truncation, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from human cathelicidin LL-37)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% cell death at 22.5 uM	Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||18591279|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.	21	
FPDB00115	AP03840|||DRAMP31342|||AP03840|||LL-37|||DRAMP31342	GIKEWKRIVQRIKDFLRNLV	Antiviral||Anti-HIV||Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 7.4 uM||Antimicrobial||Antiviral ; HIV[IC50 REP = 7.4 uM]	Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from human cathelicidin LL-37)|||Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from human cathelicidin LL-37)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% cell death at 23.6 uM	Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||18591279|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.	20	
FPDB00116	AP05207|||DRAMP31354|||AP05207|||Apelin-12|||DRAMP31354	RPRLSHKGPMPF	Anti-HIV-1 infection, activity value is IC50 = 63 ug/ml||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV[IC50 E = 63 ug/ml]	sequence truncation, mammals, animal-derived, natural derivatives|||Synthetic construct|||sequence truncation, mammals, animal-derived, natural derivatives|||Synthetic construct	N/A	N/A	"Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. 2000
FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3.|||FEBS Lett. 2000 May 4;473(1):15-8.|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||https://pubmed.ncbi.nlm.nih.gov/10802050|||FEBS Lett. 2000 May 4;473(1):15-8."	12	
FPDB00117	AP05206|||DRAMP31355|||AP05206|||Apelin-13|||DRAMP31355	QRPRLSHKGPMPF	Anti-HIV-1 infection, activity value is IC50 = 26 ug/ml||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV[IC50 E = 26 ug/ml]	sequence truncation, mammals, animal-derived, natural derivatives|||Bos taurus (Bovine)|||sequence truncation, mammals, animal-derived, natural derivatives|||Bos taurus|||Bos taurus (Bovine)	N/A	N/A	"Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. 2000
 FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3.|||FEBS Lett. 2000 May 4;473(1):15-8.|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||https://pubmed.ncbi.nlm.nih.gov/10802050|||FEBS Lett. 2000 May 4;473(1):15-8."	13	
FPDB00118	AP05205|||DRAMP31356|||AP05205|||Apelin-17|||DRAMP31356	KFRRQRPRLSHKGPMPF	Anti-HIV-1 infection, activity value is IC50 = 4.8 ug/ml||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV[IC50 E = 4.8 ug/ml]	sequence truncation, mammals, animal-derived, natural derivatives|||Synthetic construct|||sequence truncation, mammals, animal-derived, natural derivatives|||Synthetic construct	N/A	N/A	"Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. 2000
: FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3.|||FEBS Lett. 2000 May 4;473(1):15-8.|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||https://pubmed.ncbi.nlm.nih.gov/10802050|||FEBS Lett. 2000 May 4;473(1):15-8."	17	
FPDB00119	AP05204|||DRAMP31357|||AP05204|||DRAMP31357	LVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF	Anti-HIV-1 infection, activity value is IC50 = 0.3 ug/ml||Antimicrobial||Antiviral||Anti-HIV	sequence truncation, mammals, animal-derived, natural derivatives|||Bos taurus (Bovine)|||sequence truncation, mammals, animal-derived, natural derivatives|||Bos taurus (Bovine)	N/A	N/A	"Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. 2000
 FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3.|||J Virol. 2000 Dec;74(24):11972-6.|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||J Virol. 2000 Dec;74(24):11972-6."	36	
FPDB00120	AP05191	PKGPTYSWDEAKNPGGPNRCSNSKQCDGARTCSSSGFCQGTAGHAAA	Anti-HIV-1, activity value is EC50 = 0.182 uM||Antiviral||Anti-HIV	amino acid substitution, sequence truncation, bacteria-derived, natural derivatives	N/A	N/A	"Xiong C, O'Keefe BR, Byrd RA, McMahon JB.2006
 Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018.|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed"	47	
FPDB00121	AP05190	GSGPTYSWNEANNPGGPNRCSNNKQCDGARTCSSSGFCQG	Anti-HIV-1, activity value is EC50 = 0.0345 uM||Antiviral||Anti-HIV	amino acid substitution, sequence truncation, bacteria-derived, natural derivatives	N/A	N/A	"Xiong C, O'Keefe BR, Byrd RA, McMahon JB.2006
 Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018.|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed"	40	
FPDB00122	AP05189	GSGPTYSWNEANNPGGPNRCSNNKQCDGARTCSSSGFCQGTSRKPDPG	Anti-HIV-1, activity value is EC50 = 0.0076 uM||Antiviral||Anti-HIV	amino acid substitution, sequence truncation, bacteria-derived, natural derivatives	N/A	N/A	"Xiong C, O'Keefe BR, Byrd RA, McMahon JB.2006
 Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018.|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed"	48	
FPDB00123	AP04543|||Kn2-7|||CAMPSQ14095|||DRAMP18558	FIKRIARLLRKIF	Anti-Gram- E. coli AB94012 or ATCC 25922, activity value is MIC = 6.25||Anti-P. aeruginosa AB93066 or A092994 like 5 strains, activity value is MIC = 25||Anti-S. aureus AB94004 or ATCC 25923 or MRSA, activity value is MIC = 3.13 ug/ml||Anti-S. epidermidis, activity value is MIC = 2.5||Anti-E. faecalis, activity value is MIC = 5||Anti-E. faecium, activity value is MIC = 5 ug/ml||Anti-B. subtilis AB91021, activity value is MIC = 6.25 ug/ml||Anti-B. thuringiensis AB92037, activity value is MIC = 6.25 ug/ml||Anti-and M. luteus AB93113, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus AB94004, activity value is MIC = 3.13 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.13 ug/ml||Anti-Bacillus subtilis AB91021, activity value is MIC = 6.25 ug/ml||Anti-Bacillus thuringiensis AB92037, activity value is MIC = 6.25 ug/ml||Anti-Micrococcus luteus AB93113, activity value is MIC = 6.25 ug/ml||Anti-Escherichia coli AB94012, activity value is MIC = 6.25 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa AB93066, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa A092994, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa A093052, activity value is MIC = 100 ug/ml||Anti-Pseudomonas aeruginosa A093056, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa A093085, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa A093115, activity value is MIC = 100 ug/ml||Anti-S. aureus P1383, activity value is MIC = 6.25 ug/ml||Anti-Penicillin-resistant S. epidermidis P1389, activity value is MIC = 6.25 ug/ml||Anti-Methicillin resistant S. aureus P1381, activity value is MIC = 6.25 ug/ml||Anti-Methicillin resistant S. aureus P1386, activity value is MIC = 6.25 ug/ml||Anti-Methicillin resistant S. aureus P1374, activity value is MIC = 3.13 ug/ml||Anti-Methicillin resistant coagulase-negative Staphylococcus P1369, activity value is MIC = 3.13 ug/ml||Anti-Penicillin-sensitive S. epidermidis P1111, activity value is MIC = 3.13 ug/ml||Anti-S. aureus ATCC29213, activity value is MIC = 5 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 10 ug/ml||Anti-##Gram-negative bacteria: Escherichia coli AB94012, activity value is MIC = 6.25 ug/ml	amino acid substitution, animal-derived, natural derivative|||Synthetic construct	Helix||Alpha helix	"The peptide Kn2-7 had little hemolytic activity at high
concentration (Figure 1D). According to the method of Ka¨ ber
modified by Achmarine, the HC50 values of the mutant peptide
Kn2-7 and the wild-type peptide BmKn2 were 90270 ug/ml and
17130 ug/ml, respectively (Figure 1D). Therefore, the hemolytic
activity of Kn2-7 was significantly decreased, compared to the
wild-type peptide BmKn2.|||No hemolytic activity (0% hemolysis at 100 µM)|||Kn2-7 peptide: HC₅₀ value is 90.27 µg/ml. BmKn2 peptide (wild-type peptide): HC₅₀ value is 17.13 µg/ml.|||Kn2-7: 50% hemolytic concentration (HC₅₀) is 90.27 µg/ml; 
Wild-type peptide BmKn2: 50% hemolytic concentration (HC₅₀) is 17.13 µg/ml; 
(Note: Determined by human red blood cell hemolysis assay, positive control 0.1% Triton X-100 is 100% hemolysis, 0.85% physiological saline is 0% hemolysis).|||Human RBCs (> 90% percent hemolysis at 100 ug/ml)|||[Ref.22792229]Non-hemolysis at 6.25 ug/ml, 5% hemolysis at 12.5 ug/ml,10% hemolysis at 25 ug/ml 15% hemolysis at 50 ug/ml, 40% hemolysis at 100 ug/ml against human red blood cells"	"Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z, Li W.2012
 PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135. PubMed|||PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135.|||2012;7(7):e40135. doi: 10.1371/journal.pone.0040135. Epub 2012 Jul 5.|||. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135. Epub 2012 Jul 5.|||22792229|||34335511|||PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135.||Ref.22792229"	13	
FPDB00124	AP03863	CRLGRLLRRLGRCLLR	Anti-E. coli, activity value is MIC = 60 uM||Anti-B. subtilis, activity value is MIC = 60 uM||Antiviral||Anti-HIV	De novo designed, man-made sequences	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	16	
FPDB00125	AP03862	GCRRLCGRLGRRLCRLLCR	Anti-HSV-2MS in Vero cells, activity value is EC50 = 69.3 ug/ml||Anti-HSV-2MS in Vero cells, activity value is EC50 = 64.7 ug/ml||Anti-B.subtilis, activity value is MIC > 120 uM||Antiviral||Anti-HIV	De novo designed, man-made sequences	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	19	
FPDB00126	AP03861	GLRRLCGRLGRRLCRLLLR	Anti-HSV-2MS in Vero cells, activity value is EC50 = 6.37 ug/ml||Anti-HSV-2MS in Vero cells, activity value is EC50 = 15 ug/ml||Anti-B.subtilis, activity value is MIC > 120 uM||Antiviral||Anti-HIV	De novo designed, man-made sequences	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	19	
FPDB00127	AP03860	GLRCRLGRLLRRLGRCLLR	Anti-HSV-2MS in Vero cells, activity value is EC50 = 1.81 ug/ml||Anti-HSV-2MS in Vero cells, activity value is EC50 = 5.43 ug/ml||Anti-B.subtilis, activity value is MIC > 120 uM||Antiviral||Anti-HIV	De novo designed, man-made sequences	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	19	
FPDB00128	AP03859	GCRRLLGRLLRRLGRLLCR	Anti-HSV-2MS in Vero cells, activity value is EC50 = 30 ug/ml||Anti-B.subtilis, activity value is MIC > 120 uM||Antiviral||Anti-HIV	De novo designed, man-made sequences	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	19	
FPDB00129	AP03858	GSRRPVPIIYCNRRTGRCQRI	Anti-Human Immunodeficiency Virus Type 1 HIV-1IIIB, activity value is EC50 = 3.33 ug/ml||Antiviral||Anti-HIV	amino acid substitution, insects, animal-derived, natural derivative	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	21	
FPDB00130	AP03857	GSKKPVPIIYCNRRTGKCQRI	Anti-Human Immunodeficiency Virus Type 1 HIV-1IIIB, activity value is EC50 = 13.1 ug/ml||Anti-HSV-2MS in Vero cells, activity value is EC50 = 2320000 ug/ml||Antiviral||Anti-HIV	Amino acid substitution, insects, animal-derived, natural derivatives	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	21	
FPDB00131	AP03856|||DRAMP30306|||AP03856|||DRAMP30306	GLRRLLGRLLRRLGRLLLR	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 4.4 uM||Anti-HSV-2MS in Vero cells, activity value is EC50 = 2.32 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 4.4 uM||Antiviral||Anti-HIV	Amino acid substitution, de novo designed, man-made sequences|||Synthetic construct|||Amino acid substitution, de novo designed, man-made sequences|||Synthetic construct	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	19	
FPDB00132	AP03855|||DRAMP30305|||AP03855|||DRAMP30305	GLRSRIWLWVLLMIWQESNRFKRM	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 1.25 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 1.25 uM||Antiviral||Anti-HIV	Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct(derived from Dermaseptin S9)|||Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct(derived from Dermaseptin S9)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	24	
FPDB00133	AP03854|||DRAMP30303|||AP03854|||DRAMP30303	ILGPVLGLVSRTLRRVLGIL	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 2.2 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 2.2 uM||Antiviral||Anti-HIV	Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct(derived from Maximin H5)|||Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct(derived from Maximin H5)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	20	
FPDB00134	AP03853|||DRAMP30302|||AP03853|||DRAMP30302	GWLKKIESIIDAF	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 29.5 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 29.5 uM||Antiviral||Anti-HIV	template-based designed, man-made sequences|||Synthetic construct(derived from Cecropin)|||template-based designed, man-made sequences|||Synthetic construct(derived from Cecropin)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	13	
FPDB00135	AP03852|||DRAMP30301|||AP03852|||DRAMP30301	GFLDIIEKIAKSW	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 10.5 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 10.5 uM||Antiviral||Anti-HIV	template-based designed, man-made sequences|||Synthetic construct(derived from Ranatuerin 3)|||template-based designed, man-made sequences|||Synthetic construct(derived from Ranatuerin 3)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	13	
FPDB00136	AP03851|||DRAMP30300|||AP03851|||DRAMP30300	GIWSDLAEIIKKF	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 11.4 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 11.4 uM||Antiviral||Anti-HIV	template-based designed, man-made sequences|||Synthetic construct(derived from Ponericin W3)|||template-based designed, man-made sequences|||Synthetic construct(derived from Ponericin W3)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	13	
FPDB00137	AP03850|||DRAMP30298|||AP03850|||DRAMP30298	GWFDIIKKIASEL	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 10.7 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 10.7 uM||Antiviral||Anti-HIV	template-based designed, man-made sequences|||Synthetic construct(derived from Uperin 7.1)|||template-based designed, man-made sequences|||Synthetic construct(derived from Uperin 7.1)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	13	
FPDB00138	AP03849|||DRAMP30297|||AP03849|||DRAMP30297	GIIDIAKKLFESW	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 20.1 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 20.1 uM||Antiviral||Anti-HIV	template-based designed, man-made sequences|||Synthetic construct(derived from Uperin 2.7)|||template-based designed, man-made sequences|||Synthetic construct(derived from Uperin 2.7)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	13	
FPDB00139	AP03848	GLFDIIKKIAESW	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 11.7 uM||Antiviral||Anti-HIV	amino acid substitution, amphibians, animal-derived, natural derivative	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed"	13	
FPDB00140	AP03847|||AP03847|||Temporin-LTc-3r	SLSRFLRFLKIVYRRAF	Anti-S. aureus USA300 MRSA, activity value is MIC = 12.5 uM||Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-MRSA||Anti-S. aureus, activity value is MIC = 12.5 uM||Anti-E. coli, activity value is MIC = 25 uM	Amino acid substitution, amphibians, animal-derived, natural derivative|||Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Antimicrob Agents Chemother
. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. Epub 2010 Jan 19.|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||22445495|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed"	17	
FPDB00141	AP03846|||AP03846|||DASamP1|||DRAMP04317	FFGKVLKLIRKIF	Anti-S. aureus USA300 MRSA, activity value is MIC = 3.1 uM||Anti-Gram+||Antiviral||Anti-HIV||Anti-MRSA||Anti-Bacillus subtilis, activity value is MIC > 100 uM||Anti-Pseudomonas aeruginosa, activity value is MIC > 100 uM||Anti-S. aureus, activity value is MIC = 3.1 uM||Anti-E. coli, activity value is MIC > 100 uM||Antimicrobial||Antibacterial	Amino acid substitution, amphibians, animal-derived, natural derivative|||FFGKVLKLIRKIF|||Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||hemolytic HC50 25 uM.|||Human RBC (HL50 = 25 uM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed||Menousek et al., 2012|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.||Menousek et al., 2012|||Antimicrob Agents Chemother
. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. Epub 2010 Jan 19.|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed||Menousek et al., 2012|||22445495|||Int J Antimicrob Agents. 2012 May;39(5):402-406.|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed"	13	
FPDB00142	AP03845|||Uperin 7.1KRF	GWFDVVKHIAKRF	Anti-S. aureus USA300 MRSA, activity value is MIC = 50 uM||Antiviral||Anti-HIV||Anti-MRSA||Anti-S. aureus, activity value is MIC = 50 uM||Anti-E. coli, activity value is MIC = 12.5 uM	Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Antimicrob Agents Chemother
. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. Epub 2010 Jan 19.|||22445495|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed"	13	
FPDB00143	AP03844|||DRAMP31346|||AP03844|||Cathelicidin-6|||DRAMP31346	GRFKRFRKPFKKLFKKIS	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 3.2 uM||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV[IC50 REP = 3.2 uM]	Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from BMAP-27)|||Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from BMAP-27)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% cell death at 18.9 uM	"Wang G, Watson KM, Buckheit RW Jr. 2008
 Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||https://pubmed.ncbi.nlm.nih.gov/18591279|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40."	18	
FPDB00144	AP03843|||DRAMP31345|||AP03843|||BMAP-18|||DRAMP31345	GRFKRFRKKFKKLFKKIS	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 0.35 uM||Anti-HSV-2MS in Vero cells, activity value is EC50 = 27.2 uM||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV-1[IC50 REP = 0.35 uM]	Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from BMAP-27)|||Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from BMAP-27)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% cell death at 8.45 uM	"Wang G, Watson KM, Buckheit RW Jr. 2008
 Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||https://pubmed.ncbi.nlm.nih.gov/18591279|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40."	18	
FPDB00145	AP00013|||1252|||1253|||1254|||1255|||1256|||1257|||1258|||1259|||1260|||AP00013|||Aurein-1.2|||Aurein1.2|||Aurein 1.2|||Aurein1.2|||AP00013|||DRAMP01607	GLFDIIKKIAESF	Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 12 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 100 ug/ml||Anti-P. multocida, activity value is MIC = 100 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-S. epidermidis, activity value is MIC = 50 ug/ml||Anti-and S. uberis, activity value is MIC = 50 ug/ml||LC50 = 10 uM||LC50=10-100 uM||Anti-Gram+ & Gram-||Antifungal||Anticancer||Anti-B.cereus, activity value is MIC = 100 ug/ml||Anti-L.lactis, activity value is MIC = 12 ug/ml||Anti-L.innocua, activity value is MIC = 100 ug/ml||Anti-M.luteus, activity value is MIC = 100 ug/ml||Anti-P.multocida, activity value is MIC = 100 ug/ml||Anti-S.aureus, activity value is MIC = 50 ug/ml||Anti-S.epidermidis, activity value is MIC = 50 ug/ml||Anti-S.uberis, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 32||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1.024||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1.024||Anti-30630076: Mycobacterium tuberculosis, activity value is MIC = 50||Anti-30043322: A. baumannii ATCC 19606, activity value is MIC = 16 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 125||Anti-Bacillus subtilis, activity value is MIC = 254||Anti-Escherichia coli, activity value is MIC = 125||Anti-Candida abicans, activity value is MIC = 125||Anti-Candida krusei, activity value is MIC = 500||Anti-Penicillium pinophilum, activity value is MIC = 254||Anti-Aspergillus fumigates, activity value is MIC = 125||Anti-Saccharomyces cerevisiae, activity value is MIC = 125||Anti-S.aureus, activity value is MIC = 37.5 uM||activity value is MBC = 125 uM||Anti-E.Coli, activity value is MIC = 250 uM||activity value is MBC = 250 uM||Antibacterial||Anti-Bacillus cereus, activity value is MIC = 100 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 12 ug/ml||Anti-Listeria innocua, activity value is MIC = 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 uM||Anti-Pasteurella multocida, activity value is MIC = 100 ug/ml||Anti-Escherichia coli, activity value is MIC = 8 uM||Anti-Candida albicans, activity value is MIC = 32 uM	Southern bell frog Litoria aurea and Litoria raniformis, Australia|||Southern bell frog Litoria aurea and Litoria raniformis, Australia|||Litoria raniformis [Southern bell frog]|||Litoria aurea|||Litoria raniformis [Australian tree frog]|||Litoria aurea�|||Litoria auream [Australian tree frog]|||Southern bell frog Litoria aurea and Litoria raniformis, Australia|||Litoria raniformis (Southern bell frog)	Helix||Alpha helix (1 helices; 10 residues)	No hemolytic activity (0% hemolysis at 100 µM)	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia
 Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.|||Eur J Biochem
. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||10951191, 15572363, 30593676, 30630076, 30043322||PubMed 10951191||Refer 15572363||Refer 30593676|||31264322|||28478484|||31264322|||34439006|||Eur J Biochem. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x."	13	L
FPDB00146	AP00014|||AP00014|||Aurein-2.1|||DRAMP01608	GLLDIVKKVVGAFGSL	Anti-B. cereus, activity value is MIC = 50 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 6 ug/ml||Anti-L. innocua, activity value is MIC = 6 ug/ml||Anti-M. luteus, activity value is MIC = 100 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S.aureus, activity value is MIC > 100 ug/ml||Anti-S. epidermidis, activity value is MIC = 50 ug/ml||Anti-and S. uberis, activity value is MIC = 100 ug/ml||Anti-Gram+ & Gram-||Antifungal||Anticancer||Anti-B.cereus, activity value is MIC = 50 ug/ml||Anti-L.lactis, activity value is MIC = 6 ug/ml||Anti-L.innocua, activity value is MIC = 6 ug/ml||Anti-M.luteus, activity value is MIC = 100 ug/ml||Anti-S.epidermidis, activity value is MIC = 50 ug/ml||Anti-S.uberis, activity value is MIC = 100 ug/ml||Anti-Bacillus cereus, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 6 ug/ml||Anti-Listeria innocua, activity value is MIC = 6 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 100 ug/ml	Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Synthetic construct|||Litoria aurea (Green; also golden bell frog); also Litoria raniformis (Southern bell frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia
 Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.|||Eur J Biochem
. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||10951191|||Eur J Biochem. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x."	16	
FPDB00147	AP00015|||DRAMP01609	GLFDIVKKVVGALGSL	Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 12 ug/ml||Anti-L. innocua, activity value is MIC = 12 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-S. epidermidis, activity value is MIC = 50 ug/ml||Anti-and S. uberis, activity value is MIC = 100 ug/ml||Anti-Gram+ & Gram-||Antifungal||Anticancer||Antimicrobial||Antibacterial||Anti-Gram+||Anti-cancer	Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Litoria aurea (Green; also golden bell frog)	Helix	No hemolytic activity (0% hemolysis at 100 µM)	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia
 Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.|||Eur J Biochem
. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||Eur J Biochem. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||Eur J Biochem. 2000 Sep;267(17):5330-5341.Peptides. 2004 Jun;25(6):1035-1054."	16	
FPDB00148	AP00016|||AP00016|||Aurein-2.3|||DRAMP01610	GLFDIVKKVVGAIGSL	Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 25 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 100 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S. aureus, activity value is MIC = 100 ug/ml||Anti-S. epidermidis, activity value is MIC = 100 ug/ml||Anti-and S.uberis, activity value is MIC > 100 ug/ml||Anti-Gram+ & Gram-||Antifungal||Anticancer||Antimicrobial||Antibacterial||Anti-Gram+||Anti-cancer	Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Synthetic construct|||Litoria aurea (Green; also golden bell frog)	Helix	No hemolytic activity (0% hemolysis at 100 µM)	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia
 Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.|||Eur J Biochem
. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||10951191|||Eur J Biochem. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||Eur J Biochem. 2000 Sep;267(17):5330-5341.Peptides. 2004 Jun;25(6):1035-1054."	16	
FPDB00149	AP00017|||DRAMP01611	GLFDIVKKVVGTLAGL	Anti-B. cereus, activity value is MIC = 25 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 12 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-S. epidermidis, activity value is MIC = 25 ug/ml||Anti-and S. uberis, activity value is MIC = 25 ug/ml||Anti-Gram+ & Gram-||Antifungal||Anticancer||Antimicrobial||Antibacterial||Anti-Gram+||Anti-cancer	Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Litoria aurea (Green; also golden bell frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia
Reference: Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.|||Eur J Biochem
. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||Eur J Biochem. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||Eur J Biochem. 2000 Sep;267(17):5330-5341.Peptides. 2004 Jun;25(6):1035-1054."	16	
FPDB00150	AP00018|||1261|||1262|||1263|||1264|||1265|||1266|||1267|||1268|||1269|||AP00018|||Aurein-2.5|||Aurein 2.5|||Aurein 2.5|||AP00018|||DRAMP01612	GLFDIVKKVVGAFGSL	Anti-B. cereus, activity value is MIC = 50 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 12 ug/ml||Anti-L. innocua, activity value is MIC = 50 ug/ml||Anti-M. luteus, activity value is MIC = 100 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-S. epidermidis, activity value is MIC = 25 ug/ml||Anti-and S. uberis, activity value is MIC = 25 ug/ml||LC50 = 10 uM||LC50=10-100 uM||Anti-Gram+ & Gram-||Antifungal||Anticancer||Anti-Klebsiella pneumoniae NCTC 13368, activity value is MIC = 64 ug/ml||Anti-Klebsiella pneumoniae M6, activity value is MIC = 32||Anti-Acinetobacter baumanii AYE, activity value is MIC = 4||Anti-Acinetobacter baumanii ATCC 17978, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa PAO1 128, activity value is MIC = 128 ug/ml||Anti-Pseudomonas aeruginosa NCTC 13437, activity value is MIC = 128 ug/ml||Anti-Escherichia coli NCTC 12923, activity value is MIC = 16 ug/ml||Anti-Methicillin sensitive Staphylococcus aureus ATCC 9144, activity value is MIC = 8 ug/ml||Anti-Epidemic methicillin resistant Staphylococcus aureus-15, activity value is MIC = 32 ug/ml||Anti-Epidemic methicillin resistant Staphylococcus aureus-16, activity value is MIC = 32||Anti-Vancomycin sensitive Enterococcus faecalis NCTC 775, activity value is MIC = 32||Anti-Vancomycin resistant Enterococcus faecalis NCTC 12201, activity value is MIC = 64 ug/ml||Anti-Candida albicans NCPF 3179, activity value is MIC = 16 ug/ml||Antibacterial||Anti-Bacillus cereus, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 12 ug/ml||Anti-Listeria innocua, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml	Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Litoria raniformis|||Litoria aurea (green and golden bell frog)|||Litoria aurea|||Litoria aurea [Frog]|||Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Litoria raniformis (Southern bell frog); also Litoria aurea (Green; also golden bell frog)	Helix	No hemolytic activity (0% hemolysis at 100 µM)	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia
 Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.|||Eur J Biochem
. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||10951191|||31358802|||31358802|||Eur J Biochem. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||Ref.10951191"	16	L
FPDB00151	AP00019|||1270|||1271|||1272|||1273|||1274|||1275|||1276|||1277|||1278|||AP00019|||Aurein-2.6|||DRAMP01613	GLFDIAKKVIGVIGSL	Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 6 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-S. epidermidis, activity value is MIC = 50 ug/ml||Anti-and S.uberis, activity value is MIC > 100 ug/ml||LC50 = 10 uM||LC50=10-100 uM||Anti-Gram+ & Gram-||Antifungal||Anticancer||Anti-L. lactis, activity value is MIC = 6 ug||Anti-Bacillus cereus, activity value is MIC = 100 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 6 ug/ml||Anti-Listeria innocua, activity value is MIC = 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml	Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Synthetic construct|||Litoria raniformis (Southern bell frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia
 Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.|||Eur J Biochem
. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||10951191|||Eur J Biochem. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x."	16	L
FPDB00152	AP00020|||1279|||1280|||1281|||1282|||1283|||1284|||1285|||1286|||1287|||AP00020|||Aurein-3.1|||DRAMP01614	GLFDIVKKIAGHIAGSI	Anti-B.cereus, activity value is MIC > 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 12 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 100 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-S. epidermidis, activity value is MIC = 100 ug/ml||Anti-and S. uberis, activity value is MIC = 100 ug/ml||LC50=10-100 uM||LC50 = 10 uM||Anti-Gram+ & Gram-||Antifungal||Anticancer||Anti-L.lactis, activity value is MIC = 12 ug/ml||Anti-L.innocua, activity value is MIC = 100 ug/ml||Anti-M.luteus, activity value is MIC = 100 ug/ml||Anti-S.aureus, activity value is MIC = 50 ug/ml||Anti-S.epidermidis, activity value is MIC = 100 ug/ml||Anti-S.uberis, activity value is MIC = 100 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 12 ug/ml||Anti-Listeria innocua, activity value is MIC = 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 100 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml	Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Litoria raniformis|||Litoria aurea (green and golden bell frog )|||Litoria raniformis (Southern bell frog); also Litoria aurea (Green; also golden bell frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia
 Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.|||Eur J Biochem
. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||10951191|||Eur J Biochem. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||Ref.10951191"	17	L
FPDB00153	AP00021|||1288|||1289|||1290|||1291|||1292|||1293|||1294|||1295|||1296|||AP00021|||Aurein-3.2|||DRAMP01617	GLFDIVKKIAGHIASSI	Anti-B.cereus, activity value is MIC > 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 6 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 100 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-S. epidermidis, activity value is MIC = 50 ug/ml||Anti-and S. uberis, activity value is MIC = 50 ug/ml||LC50 = 10 uM||LC50=10-100 uM||Anti-Gram+ & Gram-||Antifungal||Anticancer||Anti-L.lactis, activity value is MIC = 6 ug/ml||Anti-L.innocua, activity value is MIC = 100 ug/ml||Anti-M.luteus, activity value is MIC = 100 ug/ml||Anti-S.aureus, activity value is MIC = 50 ug/ml||Anti-S.epidermidis, activity value is MIC = 50 ug/ml||Anti-S.uberis, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 6 ug/ml||Anti-Listeria innocua, activity value is MIC = 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml	Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Litoria raniformis|||Litoria aurea (green and golden bell frog)|||Litoria aurea (green; also golden bell frog); also Litoria raniformis (blue-thighed treefrog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia
 Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.|||Eur J Biochem
. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||10951191|||Eur J Biochem. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x."	17	L
FPDB00154	AP00022|||1297|||1298|||1299|||1300|||1301|||1302|||1303|||1304|||1305|||AP00022|||Aurein-3.3|||DRAMP01618	GLFDIVKKIAGHIVSSI	Anti-B.cereus, activity value is MIC > 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 12 ug/ml||Anti-L.innocua, activity value is MIC > 100 ug/ml||Anti-M. luteus, activity value is MIC = 100 ug/ml||Anti-P. multocida, activity value is MIC = 100 ug/ml||Anti-S. aureus, activity value is MIC = 100 ug/ml||Anti-S. epidermidis, activity value is MIC = 50 ug/ml||Anti-and S. uberis, activity value is MIC = 25 ug/ml||LC50 = 10 uM||LC50=10-100 uM||Anti-Gram+ & Gram-||Antifungal||Anticancer||Anti-Leuconostoc lactis, activity value is MIC = 12 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 100 ug/ml||Anti-Pasteurella multocida, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 25 ug/ml	Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Southern bell frog Litoria aurea or Litoria raniformis, Australia|||Bombus pascuorum|||Litoria raniformis (blue-thighed treefrog)	Beta	No hemolytic activity (0% hemolysis at 100 µM)	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia
 Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.|||Eur J Biochem
. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x.|||10951191|||Eur J Biochem. 2000 Sep;267(17):5330-41. doi: 10.1046/j.1432-1327.2000.01536.x."	17	L
FPDB00155	AP00023	AACARFIDDFCDTLTPNIYRPRDNGQRCYAVNGHRCDFTVFNTNNGGNPIRASTPNCKTVLRTAANRCPTGGRGKINPNA	Antiviral protein Y3: at 2 ug/ml achieved 50.0% inhibition of tobacco mosaic virus (TMV||20 ug/ml) lesions in Nicotiana glutinosa leaves. (provided by Chunfeng Wang). Submitted OCT-2002 to the SWISS-PROT data bank. It shows antiviral activity against Tobacco mosaic virus and antitumor activity against stomach cancer cells in vitro. Full sequence updated 03/	Golden oyster mushroom, Pleurotus citrinopileatus	N/A	N/A	"Wu,L.-P., Wu,Z.-J., Lin,D, Fang F, Lin Q.-Y., Xie,L.-H.2002
 Chinese J Biochem Mol Biol 2008; 24(7):597-603. OnlineJournal."	80	
FPDB00156	AP00024|||DRAMP03065|||CAMPSQ2708|||DRAMP03065	GVSGHGQHGVHG	During screening||it was found to be cytotoxic against cancer cells but not further chracterized yet. Updated 9/2017; 12/2017; 6/2022||Antimicrobial||Antibacterial||Antifungal||Antiviral||Antitumour	Blow fly Calliphora vicina|||Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)|||Calliphora vicina [Blow fly]|||Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)	N/A	No hemolysis information or data found in the reference(s) presented in this entry	"Chernysh S, Kim SI, Bekker G, Pleskach VA, Filatova NA, Anikin VB, Platonov VG, Bulet P.2002
 Proc Natl Acad Sci U S A 2002; 99 (20):12628-32. PubMed.|||Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32.|||12235362|||Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32."	12	
FPDB00157	AP00025|||DRAMP03064|||Alloferon-1|||DRAMP03064	HGVSGHGQHGVHG	Anti-It inhibited the Human Herpes Virus type 1 multiplication . Active against Gram+ S. aureus ATCC25923 or penicillin-resistant, activity value is MIC = 16||Anti-S. epidermidis penicillin-resistant, activity value is MIC = 32 ug/ml||Anti-E. coli ATCC25922 or penicillin-resistant, activity value is MIC = 8||Anti-P. aeruginosa ATCC27853 or penicillin-resistant, activity value is MIC = 8||Anti-and K. pneumoniae ATCC13883 or penicillin-resistant, activity value is MIC = 16 ug/ml||Anti-Gram+ & Gram-||Antiviral||Anticancer||Antimicrobial||Antiparasitic||Antitumor||Anti-Influenzae virus, activity value is MIC = 25 ug	Blow fly Calliphora vicina|||Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)|||Calliphora vicina [Blue blowfly]|||Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)	Rich	No hemolysis information or data found in the reference(s) presented in this entry	"Chernysh S, Kim SI, Bekker G, Pleskach VA, Filatova NA, Anikin VB, Platonov VG, Bulet P.2002
 Proc Natl Acad Sci U S A 2002; 99 (20):12628-32. PubMed.||Kuczer et al. 2011||Tu J et al., 2015|||Proc Natl Acad Sci U S A
. 2002 Oct 1;99(20):12628-32. doi: 10.1073/pnas.192301899. Epub 2002 Sep 16.|||Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32.|||https://pubmed.ncbi.nlm.nih.gov/12235362|||Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32."	13	
FPDB00158	AP00029|||1186|||1190|||1194|||1198|||CE-MA|||DRAMP03914|||DRAMP03963	KWKLFKKIKFLHSAKKF	Antiviral||Antiparasitic||anti-sepsis||Antimalarial||Anticancer||activity value is IC50 = 85.3 uM||activity value is IC50 = 100 uM||activity value is IC50 = 65 uM||Anti-Gram- E. coli, activity value is MIC = 6.25 uM||Anti-S. typhimurium, activity value is MIC = 0.78 uM||Anti-P. aeruginosa, activity value is MIC = 1.56 uM||Anti-B. subtilis, activity value is MIC = 1.56 uM||Anti-S. pyogenes, activity value is MIC = 0.78 uM||Anti-and S. aureus, activity value is MIC = 3.12 uM||Anti-Candida albicans, activity value is MIC = 250 ug/ml||Anti-C. glabrata, activity value is MIC = 512 ug/ml||Anti-A. fumigatus, activity value is MIC > 1000 ug/ml||Anti-M. canis, activity value is MIC > 1000 ug/ml||Antimicrobial||Antifungal||Antibacterial	hybrid peptide, designed, man-made sequences|||Synthetic construct (De novo design)|||Synthetic construct	Helix	The hemolytic activity of CA-MA and its analogs on human red blood cells was tested at a concentration of 100 μM, and the results showed that the hemolysis rate of all peptides was 0% (see Table 2 for specific data).	"Oh H, Hedberg M, Wade D, Edlund C.
 Antimicrob Agents Chemother. 2000 Jan;44(1):68-72.PubMed.|||2000 Feb 15;1463(2):209-18. doi: 10.1016/s0005-2736(99)00210-2.|||33676184|||Int J Mol Sci. 2012; 13(11): 15042-15053.|||Biochemistry. 2000 Oct 3;39(39):11855-11864."	17	L
FPDB00159	AP00035|||AP00035|||Plantaricin A|||DRAMP00143	KSSAYSLQMGATAIKQVKKLFKKWGW	Anti-Gram+ & Gram-||Anticancer||L. sake NCDO 2714||L. plantarum 965||Antimicrobial||Antibacterial	Lactiplantibacillus plantarum; (old) Lactobacillus plantarum C11, WCFS1, V90|||Lactiplantibacillus plantarum; (old) Lactobacillus plantarum C11, WCFS1, V90|||Lactobacillus plantarum|||Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Gram-positive bacteria)	Helix	N/A	"Nissen-Meyer J, Larsen AG, Sletten K, Daeschel M, Nes IF.1993
 J Gen Microbiol. 1993 Sep;139(9):1973-8. PubMed.|||J Gen Microbiol
. 1993 Sep;139(9):1973-8. doi: 10.1099/00221287-139-9-1973.|||15805109|||J Gen Microbiol. 1993 Sep;139(9):1973-1978."	26	
FPDB00160	AP00054|||AP00054|||Maximin-6|||BLP-7|||DRAMP01112|||Maximin-6|||BLP-7|||AP00054|||DRAMP01112	GIGGALLSAGKSALKGLAKGLAEHFAN	Anti-E. coli, activity value is MIC = 6.3 uM||Anti-S. aureus, activity value is MIC = 6.3 uM||Anti-2012. ALso has anticancer effects on human hepatic adenocarcinoma SK-HEP-1 cells, activity value is IC50 = 0.99 uM||Anti-Hep G2 cells, activity value is IC50 = 2.8 uM||C. albicans||Anti-E.coli, activity value is MIC = 16 ug/ml||Anti-S.aureus, activity value is MIC = 16 ug/ml||Anti-C.albicans, activity value is MIC = 32 ug/ml||Antimicrobial||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Anticancer	Oriental fire-bellied toad/frog, Bombina orientalis, Asia|||Oriental fire-bellied toad/frog, Bombina orientalis, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina orientalis|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Bombina orientalis|||Oriental fire-bellied toad/frog, Bombina orientalis, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	N/A	Shows little hemolytic activity|||Human RBCs (>80% hemolysis at 256 ug/ml)	"Miele R, Borro M, Fiocco D, Barra D, Simmaco M.2000
 Peptides 2000; 21:1681-1686. PubMed.||Zhou et al., 2017|||Peptides
. 2000 Nov;21(11):1681-6. doi: 10.1016/s0196-9781(00)00317-x.||Zhou et al., 2017|||11835991|||28636781|||Eur J Immunol. 2005 Apr;35(4):1220-1229.|||11835991|||28636781|||Peptides 2000; 21:1681-1686. doi: 10.1016/s0196-9781(00)00317-x.||Zhou et al., 2017|||Eur J Immunol. 2005 Apr;35(4):1220-1229.Peptides. 2002 Mar;23(3):427-435.|||Peptides 2000; 21:1681-1686. PubMed."	27	
FPDB00161	AP00090|||1001|||1009|||1017|||1025|||1033|||AP00090|||Gaegurin-6|||DRAMP02296|||Gaegurin-6|||AP00090	FLPLLAGLAANFLPTIICKISYKC	Anti-M. luteus, activity value is MIC = 2.5 ug/ml||Anti-S. epidermidis, activity value is MIC = 10 ug/ml||Anti-B. subtilis, activity value is MIC = 10 ug/ml||Anti-K. pneumoniae, activity value is MIC = 50 ug/ml||Anti-S. dysentariae, activity value is MIC = 50 ug/ml||Anti-P.putida, activity value is MIC = 150 ug/ml||Anti-P.aeruginosa, activity value is MIC = 150 ug/ml||Anti-E. coli, activity value is MIC = 100 ug/ml||Anti-S. cerevisiae, activity value is MIC = 50 ug/ml||Anti-C. albicans, activity value is MIC = 50 ug/ml||activity value is IC50 = 6.49 ug/ml||activity value is IC50 = 5.62 ug/ml||activity value is IC50 = 5.75 ug/ml||activity value is IC50 = 4.91 ug/ml||activity value is IC50 = 4.88 ug/ml||Antibacterial||Antifungal||Antiparasitic||Anti-Micrococcus luteus, activity value is MIC = 2.5 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 10 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 10 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 50 ug/ml||Anti-Shigella dysentariae, activity value is MIC = 50 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 100 ug/ml||Anti-Eshchericia coli, activity value is MIC = 50 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC = 50 ug/ml||Anti-Candida albicans, activity value is MIC = 50 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 200 ug/ml||Anti-Proteus mirabilis, activity value is MIC > 200 ug/ml||Anti-Serratia marcescens, activity value is MIC > 200 ug/ml||Anti-Gram+ & Gram-||candidacidal||Anticancer	skin, Korean wrinkled frog Rana rugosa, Asia|||skin, Korean wrinkled frog Rana rugosa, Asia|||Rana rugosa [Japanese wrinkled frog]|||Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)|||Rana rugosa [Japanese wrinkled frog]|||skin, Korean wrinkled frog, Glandirana emeljanovi, previously Rana rugosa, Asia	N/A	"Hemolytic activity test results: At a concentration of 100 μg/ml, the hemolysis rates of gaegurin 1-6 on human red blood cells were all below 2%, while the positive control melittin showed a hemolysis rate of 37.67% at 10 μg/ml and reached 98.92% at 100 μg/ml.

Sample data:

gaegurin 1: Hemolysis rate 0.59% at 100 μg/ml.

gaegurin 2: Hemolysis rate 0.82% at 100 μg/ml.

gaegurin 3: Hemolysis rate 1.20% at 100 μg/ml.

gaegurin 4: Hemolysis rate 1.67% at 100 μg/ml.

gaegurin 5: Hemolysis rate 1.01% at 100 μg/ml.

gaegurin 6: Hemolysis rate 0.86% at 100 μg/ml.|||Micrococcus luteus ( MIC = 2.5 ug/ml), Staphylococcus epidermidis ( MIC = 10 ug/ml), Bacillus subtilis ( MIC = 10 ug/ml), Klebsiella pneumoniae ( MIC = 50 ug/ml), Shigella dysentariae ( MIC = 50 ug/ml), Pseudomonas putida ( MIC = 50 ug/ml), Pseudomonas aeruginosa ( MIC = 100 ug/ml), Eshchericia coli ( MIC = 50 ug/ml), Saccharomyces cerevisiae ( MIC = 50 ug/ml), Candida albicans ( MIC = 50 ug/ml), Salmonella typhimurium ( MIC = 200 ug/ml), Proteus mirabilis ( MIC = >200 ug/ml), Serratia marcescens ( MIC = >200 ug/ml)|||In Document 8 (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1994), six gaegurin family antimicrobial peptides (gaegurin 1-6) were isolated from the skin of the wrinkled frog (Rana rugosa), and their hemolytic activity was extremely low; at a concentration of 100 µg/ml, the hemolysis rates were 0.59% for gaegurin 1, 0.82% for gaegurin 2, 1.20% for gaegurin 3, 1.67% for gaegurin 4, 1.01% for gaegurin 5, and 0.86% for gaegurin 6; as a control, the bee venom hemolytic peptide had a hemolysis rate of 98.92% at 100 µg/ml."	"Park JM, Jung J-E, Lee BJ.1994
 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-54.PubMed.|||Biochem Biophys Res Commun
. 1994 Nov 30;205(1):948-54. doi: 10.1006/bbrc.1994.2757.|||7999137|||Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.||Ref.7999137|||7999137|||Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-54.doi: 10.1006/bbrc.1994.2757.|||Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-54.PubMed."	24	L
FPDB00162	AP00094|||1427|||AP00094|||Temporin-A	FLPLIGRVLSGIL	Anti-S. pyogenes beta hem. group A, activity value is MIC = 1||Anti-E. coli, activity value is MIC = 6.2||Anti-and A. baumannii, activity value is MIC = 24 uM||Anti-including parasites L. donovani and L. mexicana . Also active against C. jeikeium ATCC BAA-949, activity value is MIC = 8 uM||15% Cytotoxicity at 0.5 ug/ml||Anti-B. megateriurn Bml I, activity value is MIC = 1.2 uM||Anti-S. aureus Cowanl, activity value is MIC = 2.3 uM||Anti-Y. pseudotuberculosis, activity value is MIC = 2 uM||Anti-S. pyogenes/3 hem. group A, activity value is MIC = 2 uM||Anti-E. coli D21, activity value is MIC = 11.9 uM||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Chemotactic||Wound healing||Anticancer	European common frog, Rana temporaria|||European common frog, Rana temporaria|||Rana temporaria [european common frog]	Helix	"Hemolytic activity test results: Temporin A and Temporin B both showed less than 1% hemolysis of human red blood cells at a concentration of 120 μM, whereas bee venom peptide (melittin) can cause more than 90% red blood cell hemolysis at 0.9 μM.

Example data:

Temporin A: Hemolytic concentration > 120 μM.

Temporin B: Hemolytic concentration > 120 μM.

Melittin: Hemolytic concentration 0.9 μM.|||The hemolytic concentration of temporin A on human red blood cells is >120 µM.

The hemolytic concentration of temporin B on human red blood cells is >120 µM.

The hemolytic concentration of melittin on human red blood cells is 0.9 µM.

The hemolytic concentration of melittin-like peptide (MLP) on human red blood cells is 0.5 µM.

The hemolytic concentration of defensin 1 (esculentin 1) on human red blood cells is >200 µM.

The hemolytic concentration of cecropin A on human red blood cells is >400."	"Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.1996
 Eur J Biochem. 1996 Dec 15;242(3):788-92. PubMed.||Swithenbank et al., 2020||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90|||Eur J Biochem
. 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||Swithenbank et al., 2020||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90|||9022710, 30043322|||Eur J Biochem. 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||Swithenbank et al., 2020||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90|||1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90|||Eur J Biochem. 1996 Dec 15;242(3):788-92. PubMed."	13	L
FPDB00163	AP00098|||AP00098|||Temporin-F|||CAMPSQ14028|||DRAMP01744|||DRAMP01743	FLPLIGKVLSGIL	Anti-B. megaterium and E. coli B21, activity value is MIC = 64 uM||Anti-E.cloacae beta12, activity value is MIC > 128 uM||Anti-P.aeruginosa PA14, activity value is MIC > 128 uM||Anti-S.epidermidis ATCC12228, activity value is MIC > 128 uM||Anti-B. subtilis 3562, activity value is MIC = 80 ug/ml||Anti-C.albicans, activity value is MIC = 320 ug/ml||Antibacterial||Anti-S. aureus K52, activity value is MIC = 4.4 uM||Anti-S. aureus K35, activity value is MIC = 4.4 uM||Anti-S. aureus ATCC25923, activity value is MIC = 5.2 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 20.9 uM||Anti-E. faecium 18578, activity value is MIC = 17.5 uM||Antimicrobial||Anti-Gram+||Anti-Gram-||Antiparasitic	European common frog, Rana temporaria|||European common frog, Rana temporaria|||Rana temporaria [european common frog]|||Synthetic construct|||Rana temporaria (European common frog)	Helix	"Hemolytic activity test results: Temporin A and Temporin B both showed less than 1% hemolysis of human red blood cells at a concentration of 120 μM, whereas bee venom peptide (melittin) can cause more than 90% red blood cell hemolysis at 0.9 μM.

Example data:

Temporin A: Hemolytic concentration > 120 μM.

Temporin B: Hemolytic concentration > 120 μM.

Melittin: Hemolytic concentration 0.9 μM."	"Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.1996
 Eur J Biochem. 1996 Dec 15;242(3):788-92. PubMed.|||Eur J Biochem
. 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.|||9022710|||10940378|||Eur J Biochem. 1996 Dec 15;242(3):788-792."	13	
FPDB00164	AP00101|||AP00101|||Temporin-L|||Temporin B|||Temporin B|||AP00101	FVQWFSKFLGRIL	Active against B. megaterium and E. coli  . Active against parasites L. mexicana  .||Antibacterial||Anti-Klebsiella pneumoniae NCTC 13368, activity value is MIC = 16 ug/ml||Anti-Klebsiella pneumoniae M6, activity value is MIC = 16 ug/ml||Anti-Acinetobacter baumanii AYE, activity value is MIC = 4 ug/ml||Anti-Acinetobacter baumanii ATCC 17978, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa PAO1 128, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa NCTC 13437, activity value is MIC = 32||Anti-Escherichia coli NCTC 12923, activity value is MIC = 4 ug/ml||Anti-Methicillin sensitive Staphylococcus aureus ATCC 9144, activity value is MIC = 2 ug/ml||Anti-Epidemic methicillin resistant Staphylococcus aureus-15, activity value is MIC = 4 ug/ml||Anti-Epidemic methicillin resistant Staphylococcus aureus-16, activity value is MIC = 4 ug/ml||Anti-Vancomycin sensitive Enterococcus faecalis NCTC 775, activity value is MIC = 4||Anti-Vancomycin resistant Enterococcus faecalis NCTC 12201, activity value is MIC = 8 ug/ml||Anti-Candida albicans NCPF 3179, activity value is MIC = 8 ug/ml||Antifungal	European common frog, Rana temporaria|||European common frog, Rana temporaria|||Rana temporaria [european common frog]|||Rana temporaria [Frog]|||Rana temporaria [Frog]|||European common frog, Rana temporaria	Helix	"Hemolytic activity test results: Temporin A and Temporin B both showed less than 1% hemolysis of human red blood cells at a concentration of 120 μM, whereas bee venom peptide (melittin) can cause more than 90% red blood cell hemolysis at 0.9 μM.

Example data:

Temporin A: Hemolytic concentration > 120 μM.

Temporin B: Hemolytic concentration > 120 μM.

Melittin: Hemolytic concentration 0.9 μM."	"Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.1996
 Eur J Biochem. 1996 Dec 15;242(3):788-92. PubMed.||ref for AP00095||Molecules. 2015 Feb 6;20(2):2775-85|||1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||ref for AP00095||Molecules. 2015 Feb 6;20(2):2775-85|||Eur J Biochem
. 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||ref for AP00095||Molecules. 2015 Feb 6;20(2):2775-85|||9022710|||31358802|||31358802|||Eur J Biochem. 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||ref for AP00095||Molecules. 2015 Feb 6;20(2):2775-85"	13	
FPDB00165	AP00128|||1323|||1324|||1325|||1326|||1335|||1336|||1337|||1338|||1347|||1348|||1349|||1351|||AP00128|||Cecropin-B|||DRAMP03507|||AP00128	KWKIFKKIEKVGRNIRNGIIKAGPAVAVLGEAKAL	Lethal concentrations against E. coli D21 or D31 (0.0.3-0.36 uM)||S. marsescens Strain 12 (2.6 uM)||P. aeruginosa (2.98 uM)||B. subtilis (17 uM)||B. megaterium (0.64 uM)||B.thuringiensis (>88 uM)||S.fecalis (>88 uM)||and M. luteus (0.29 uM). UPdated 10/2020||activity value is IC50 = 161.76 ug/ml||activity value is IC50 = 184.81 ug/ml||activity value is IC50 = 115.12 ug/ml||activity value is IC50 = 97.93 ug/ml||activity value is IC50 = 87.47 ug/ml||activity value is IC50 = 92.9 ug/ml||activity value is IC50 = 61.86 ug/ml||activity value is IC50 = 77.51 ug/ml||activity value is IC50 = 232.4 ug/ml||activity value is IC50 = 240.4 ug/ml||activity value is IC50 = 181.1 ug/ml||Cytotoxicity=196.3 ug/ml||Antibacterial||Anti-Escherichia coli D21, activity value is MIC = 0.36 uM||Anti-Escherichia coli D31, activity value is MIC = 0.3 uM||Anti-Serratia marsescens, activity value is MIC = 2.6 uM||Anti-Serratia marsescens Strain 122, activity value is MIC = 12 uM||Anti-Pseudomonas aeruginosa OT97, activity value is MIC = 2.9 uM||Anti-Xenorhabdus nematophilus Xn21, activity value is MIC = 1.6 uM||Anti-Bacillus subtilis Bsll, activity value is MIC = 17 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 0.64 uM||Anti-Bacillus thuringiensis Btll, activity value is MIC > 88 uM||Anti-Streptococcus fecalis Ds16, activity value is MIC > 88 uM||Anti-Streptococcus fecalis AD-4, activity value is MIC > 88 uM||Anti-Micrococcus luteus MI11, activity value is MIC = 0.29 uM	Chinese oak silk moth, Antheraea pernyi|||Chinese oak silk moth, Antheraea pernyi|||Antheraea pernyi [Chinese oak silk moth]|||Antheraea pernyi (Chinese oak silkmoth)|||Chinese oak silk moth, Antheraea pernyi	N/A	N/A	"Qu X-M, Steiner H, Engstroem A, Bennich H, Boman HG.1982
 Eur. J. Biochem. 1982; 127: 219-224. PubMed.|||Eur J Biochem
. 1982 Sep;127(1):219-24. doi: 10.1111/j.1432-1033.1982.tb06858.x.|||6754375|||Biomed Environ Mass Spectrom. 1987 Nov;14(11):669-673.|||Eur. J. Biochem. 1982; 127: 219-224. doi: 10.1111/j.1432-1033.1982.tb06858.x."	35	L
FPDB00166	AP00135|||DRAMP03077|||AP00135|||DRAMP03077	GWLKKIGKKIERVGQHTRDATIQTIGVAQQAANVAATLK	Anti-Gram+ & Gram-||Antifungal||anti-sepsis||Anticancer||Antimicrobial||Antibacterial	the Medfly, Ceratitis capitata; also housefly, Musca domestica|||Ceratitis capitata (Mediterranean fruit fly) (Musca domestica)|||the Medfly, Ceratitis capitata; also housefly, Musca domestica|||Ceratitis capitata (Mediterranean fruit fly) (Musca domestica)	Helix||Alpha helix	N/A	"Rosetto M, Manetti AGO, Marchini D, Dallai R., Telford JL.1993
 Gene 1993; 134: 241-243. PubMed.|||1993 Dec 8;134(2):241-3. doi: 10.1016/0378-1119(93)90100-h.|||Gene
. 1993 Dec 8;134(2):241-3. doi: 10.1016/0378-1119(93)90100-h.|||Gene. 1993 Dec 8;134(2):241-243.|||Gene 1993; 134: 241-243. doi: 10.1016/0378-1119(93)90100-h.|||Gene. 1993 Dec 8;134(2):241-243."	39	
FPDB00167	AP00140	SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEAAREEEFFYKKQKEQLERLKNDQIHQAEFHHQQIKEHEEAIQRHKDFL	It showed no activity against G- bacteria nor fungi tested.	fly, Drosophila virilis	Rich	"When SK84 in gradient concentrations from 1 to 100000 uM was
incubated with mouse or human RBCs, only about 0.01% hemolytic
activity was observed after 1 h incubation at 100000 uM. Our results
indicate SK84 is not toxic to mouse and human RBCs."	"Lu J, Chen ZW.2010
 Peptides. 2010; 31: 44-50. PubMed."	79	
FPDB00168	AP00144|||1116|||1306|||1307|||1308|||1309|||1310|||1311|||1312|||1313|||1314|||1359|||1365|||1371|||1377|||1383|||1389|||1395|||1401|||1407|||1413|||AP00144|||Magainin-2|||Magainin-2 amide|||DRAMP02271|||Magainin 2|||AP00144	GIGKFLHSAKKFGKAFVGEIMNS	Anti-E. coli D31, activity value is MIC = 5 ug/ml||Anti-S. epidermidis, activity value is MIC = 10 ug/ml||Anti-C. freundii, activity value is MIC = 30 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-C. albicans, activity value is MIC = 80 ug/ml||Anti-and S. marcescens, activity value is MIC = 100 ug/ml||activity value is IC50 = 110 uM||activity value is IC50 = 32.3 uM||activity value is IC50 = 54.1 uM||activity value is IC50 = 28.6 uM||activity value is IC50 = 484 uM||activity value is IC50 = 52.4 uM||activity value is IC50 = 57.8 uM||activity value is IC50 = 135.3 uM||activity value is IC50 = 31 uM||activity value is IC50 = 59.4 uM||activity value is IC50 > 150 ug/ml||activity value is IC50 > 200 ug/ml||Antibacterial||Antifungal||Antiparasitic||Anti-Escherichia coli D31, activity value is MIC = 5 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 10 ug/ml||Anti-Escherichia coli, activity value is MIC = 50 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 10 ug/ml||Anti-Citrobacter freundii, activity value is MIC = 30 ug/ml||Anti-Enterobacter cloacae, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 100 ug/ml||Anti-Serratia marcescens, activity value is MIC = 100 ug/ml||Anti-Proteus mirabilis, activity value is MIC > 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Streptococcus fecalis, activity value is MIC > 100 ug/ml||Anti-Candida albicans, activity value is MIC = 80 ug/ml||Anti-Streptococcus fecalis Paramecium caudatum, activity value is MIC = 10 ug/ml||Anti-Euglena gracilis ] [ - E.coli ATCC 25922, activity value is MIC = 62||Anti-Klebsiella Pneumonae ATCC 13883, activity value is MIC = 125||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 125||Anti-Candida ablicansATCC 14053, activity value is MIC = 250||Anti-Gram+ & Gram-||Antiviral||candidacidal||Insecticidal||Spermicidal||anti-sepsis||Antimalarial||Synergistic AMPs||Wound healing||Anticancer	skin; Stomach, African clawed frog, Xenopus laevis, Africa|||skin; Stomach, African clawed frog, Xenopus laevis, Africa|||Xenopus laevis [African clawed frog]|||Xenopus ruwenzoriensis (Uganda clawed frog)|||skin; Stomach, African clawed frog, Xenopus laevis, Africa	Helix	"Since these amphiphilic peptides may be membrane dis ruptive
(12), magainin 2 was assayed for hemolytic activityagainst human erythrocytes (Fig. 4B). Unlike mellitin, ahemolytic, amphiphilic 26-amino acid peptide from beevenom (12), magainin 2 was not hemolytic up to at least 0.00015 ug/ml in phosphate-buffered normal saline (Fig. 4B). Theabsence of hemolytic activity of magainin 2 is striking in thatit possesses a potential hydrophobic moment very similar tomellitin (12)|||​|||[ Refer PubMed : 3299384 :- Escherichia coli D31 ( MIC = 5 ug/ml), Klebsiella pneumoniae ( MIC = 10 ug/ml), Pseudomonas putida ( MIC = 10 ug/ml), Staphylococcus epidermidis ( MIC = 10 ug/ml), Citrobacter freundii ( MIC = 30 ug/ml), Enterobacter cloacae ( MIC = 50 ug/ml), Escherichia coli ( MIC = 50 ug/ml), Staphylococcus aureus ( MIC = 50 ug/ml), Candida albicans ( MIC = 80 ug/ml), Pseudomonas aeruginosa ( MIC = 100 ug/ml), Serratia marcescens ( MIC = 100 ug/ml), Proteus mirabilis ( MIC = >100 ug/ml), Streptococcus fecalis ( MIC = >100 ug/ml)Paramecium caudatum ( MIC = 10 ug/ml), Amoeba proteus , Euglena gracilis ] [ Refer PubMed : 1717472 :- E.coli ATCC 25922 ( MIC = 62-125 ug/ml), Klebsiella Pneumonae ATCC 13883 ( MIC = 125-250 ug/ml), Pseudomonas aeruginosa ATCC 27853 ( MIC = 125-250 ug/ml), Staphylococcus aureus ATCC 29213 ( MIC = >500 ug/ml), Streptococcus faecalis ATCC 29212 ( MIC = >500 ug/ml), Candida ablicansATCC 14053 ( MIC = 250-500 ug/ml) ], [ Refer Pubmed ID 35073323: Mycoplasma pneumoniae ]|||Xanthomonas axonopodis pv. glycines (MIC = 13 uM), Escherichia coli (MIC = 13 uM), Pseudomonas aeruginosa (MIC = 26 uM)|||In Document 4 (Proc. Natl. Acad. Sci. USA 1987), magainin 1 and magainin 2, isolated from the skin of the African clawed frog (Xenopus laevis), showed no hemolytic activity against human erythrocytes, and no hemolysis was observed even at concentrations up to 150 µg/ml in phosphate-buffered saline.|||Magainin 2 shows no hemolytic activity on human red blood cells even at concentrations as high as 150 µg/ml; whereas melittin, the bee venom peptide, exhibits significant hemolytic effects at low concentrations."	"Zasloff M.1987
 Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. PubMed.||Peschel et al., 2001|||1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.||see ref AP4787||Peschel et al., 2001|||Proc Natl Acad Sci U S A
. 1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.||Peschel et al., 2001|||1717472 , 3299384, 35073323|||23029273|||Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-5453.|||1717472 , 3299384, 35073323||PubMed : 3299384||PubMed : 1717472||Refer Pubmed ID 35073323|||Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.|||1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.|||Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. PubMed."	23	L
FPDB00169	AP00152|||3268|||3269|||AP00152|||Tritrpticin|||TOAC0-TRP3|||DRAMP02975|||Tritrpticin|||AP00152	VRRFPWWWPFLRR	Anti-A.fumigatus, activity value is MIC = 250 ug/ml||Anti-S. typhimurium KCTC 1926, activity value is MIC = 32 ug/ml||Anti-B. subtilis KCTC 3068, activity value is MIC = 8 ug/ml||Anti-and S. aureus KCTC 1621 or 2 strains MRSA, activity value is MIC = 16||Anti-2 strains vancomycin-resistant E. faecium, activity value is MIC = 32 ug/ml||activity value is IC50 > 200 ug/ml||activity value is IC50 = 142 ug/ml||Anti-Gram+ & Gram-||Antifungal||Anti-MRSA||Hemolytic||Anticancer||Anti-8706838: Aspergillus fumigatus, activity value is MIC = 250 ug/ml||Anti-Candida albicans, activity value is MIC = 1000 ug/ml||Anti-16563706 : Escherichia coli, activity value is MIC = 32 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 32 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||Anti-methicillin-resistant Staphylococcus aureus 1, activity value is MIC = 32 ug/ml||Anti-vancomycin resistant Enterococcus faecium 1, activity value is MIC = 32 ug/ml||Anti-MRSA 2, activity value is MIC = 64 ug/ml||Anti-VRE2, activity value is MIC = 32 ug/ml||Anti-Escherichia coli, activity value is MIC = 16 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 16 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||Anti-12681513: E. coli, activity value is MIC = 32 ug/ml||Anti-S. typhimurium, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa, activity value is MIC = 32 ug/ml||Anti-B. subtilis, activity value is MIC = 8 ug/ml||Anti-S. aureus, activity value is MIC = 16 ug/ml||Anti-S. epidermidis, activity value is MIC = 8 ug/ml||Anti-E. coli D31, activity value is MIC = 4||Anti-Streptococcus group D . Fungi: Aspergillus fumigatus, activity value is MIC = 250 ug/ml||Antibacterial	pig|||pig|||Sus scrofa [pig]|||Synthetic construct|||Sus scrofa (Pig)|||Sus scrofa [pig]|||pig	Nonhelixbeta	C terminal: CO2H - Human RBC (70% hemolysis at 100 uM); C terminal: NH2 - Human RBC (<60% hemolysis at 100 uM)|||Human RBCs [7% hemolysis at 190 uM]|||C terminal: CO2H - Human RBC (70% hemolysis at 100 uM); C terminal: NH2 - Human RBC (<60% hemolysis at 100 uM)	"Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K.1996
 FEBS Lett. 1996 Jul 15;390(1):95-8.PubMed|||FEBS Lett. 1996 Jul 15;390(1):95-8.PubMed|||Comparative Study FEBS Lett
. 1996 Jul 15;390(1):95-8. doi: 10.1016/0014-5793(96)00637-0.|||8706838, 16563706, 12681513|||31672543|||FEBS Lett. 1996 Jul 15;390(1):95-98.|||8706838, 16563706, 12681513|||FEBS Lett. 1996 Jul 15;390(1):95-8.doi: 10.1016/0014-5793(96)00637-0."	13	L
FPDB00170	AP00165|||1706|||AP00165|||Dermaseptin-B3|||Dermaseptin DRS-DI4-like peptide|||Dermaseptin-6|||DRAMP01678	ALWKNMLKGIGKLAGQAALGAVKTLVGA	Anti-Gram+ & Gram-||Anticancer||Cytotoxicity =12 uM||Anti-S.aureus ATCC 25293, activity value is MIC = 1.3 uM||Anti-P.aeruginosa CIP A22, activity value is MIC = 2.3 uM||Anti-P.aeruginosa ATCC 27853, activity value is MIC = 5 uM||Anti-E.coli ATCC 25922, activity value is MIC = 2.6 uM||Anti-E.coli 54127, activity value is MIC = 2.3 uM||Antibacterial||Staphylococcus aureus||Escherichia coli||Pseudomonas aeruginosa||Candida albicans||Paracoccidioides brasiliensis||Antimicrobial||Anti-Gram+	South American frog, Phyllomedusa bicolor|||South American frog, Phyllomedusa bicolor|||Phyllomedusa bicolor [Two-colored leaf frog]|||Phyllomedusa burmeisteri [Brazilian common walking leaf frog]|||Phyllomedusa tarsius [Brownbelly leaf frog]|||Phyllomedusa tarsius (Brownbelly leaf frog)	N/A	N/A	"Charpentier S, Amiche M, Mester J, Vouille V, Le Caer JP, Nicolas P, Delfour A.1998
 J Biol Chem 1998; 273 (24): 14690-7. PubMed.|||J Biol Chem
. 1998 Jun 12;273(24):14690-7. doi: 10.1074/jbc.273.24.14690.|||9614066|||Submitted (AUG-2006) to UniProtKB."	28	L
FPDB00171	AP00166|||AP00166|||Pleurocidin|||DRAMP02350|||AP00166	GWGSFFKKAAHVGKHVGKAALTHYL	Anti-Highly active against A. salmonicida 99-1, activity value is MIC = 2 uM||Anti-A. salmonicida 97-4, activity value is MIC = 2 uM||Anti-S. enterica serovar Typhimurium MS7953s or 14028s or I or II, activity value is MIC = 2||Anti-P. aeruginosa K799 or Z61, activity value is MIC = 4||Anti-E. coli CGSC4908 or UB1005 or DC2, activity value is MIC = 2||Anti-S. epidermidis C621, activity value is MIC = 8 uM||Anti-methicillin-resistant S. aureus C623 or MRSA, activity value is MIC = 8 uM||Anti-C. albicans C627, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 2.2||Anti-A. salmonicida, activity value is MIC = 2||Anti-P. aeruginosa, activity value is MIC = 4||Anti-C. aquatilis, activity value is MIC = 2.2||Anti-P. haemolytica, activity value is MIC = 4.4||Anti-positive B. subtilis, activity value is MIC = 1.1||Anti-S. aureus, activity value is MIC = 17.7||Anti-S. epidermidis, activity value is MIC = 8 uM||Anti-UA 140, activity value is MIC = 8||Anti-L. fermenti, activity value is MIC = 2||Anti-Gram+ & Gram-||Antifungal||candidacidal||Chemotactic||Anti-MRSA||Antibiofilm||Anticancer||Antibacterial||Anti-Escherichia coli, activity value is MIC = 2.2||Anti-Leucothrix mucor, activity value is MIC > 35 uM||Anti-Serratia marcescens, activity value is MIC > 35 uM||Anti-Pseudomonas aeruginosa, activity value is MIC > 35 uM||Anti-Aeromonas salmonicida, activity value is MIC = 17.7||Anti-Cytophaga aquatilis, activity value is MIC = 2.2||Anti-Pasteurella haemolytica, activity value is MIC = 4.4||Anti-Salmonella typhimurium I, activity value is MIC = 8.8||Anti-Salmonella typhimurium II, activity value is MIC = 8.8||Anti-Bacillus subtilis, activity value is MIC = 1.1||Anti-Staphylococcus aureus, activity value is MIC = 17.7	the skin mucous secretions, Winter flounder, Pleuronectes americanus|||the skin mucous secretions, Winter flounder, Pleuronectes americanus|||Pseudopleuronectes americanus [Winter flounder]|||Pseudopleuronectes americanus (Winter flounder 4)|||the skin mucous secretions, Winter flounder, Pleuronectes americanus	Helix	Refer 30508627 Mouse RBC (12% hemolysis at 32 uM)	"Cole AM, Weis P, Diamond G.1997
 J. Biol. Chem. 1997; 272:12008-12013. Pub-Med.||Tao R et al., 2011|||J. Biol. Chem. 1997; 272:12008-12013. Pub-Med.|||Comparative Study J Biol Chem
. 1997 May 2;272(18):12008-13. doi: 10.1074/jbc.272.18.12008.||Tao R et al., 2011|||9115266 , 10898673 , 12950255 , 12878506, 30508627|||J Biol Chem. 1997 May 2;272(18):12008-12013.|||J. Biol. Chem. 1997; 272:12008-12013. doi: 10.1074/jbc.272.18.12008.||Tao R et al., 2011"	25	
FPDB00172	AP00191|||AP00191|||Gomesin c|||DRAMP18495|||Gomesin c|||AP00191	QCRRLCYKQRCVTYCRGR	Anti-N. asteroides, activity value is MIC = 0.4||Anti-X. campestris, activity value is MIC = 0.4||Anti-S. cerevisiae, activity value is MIC = 0.4||Anti-and B. bassiana, activity value is MIC = 12.5||Anti-Escherichia coli SBS 363, activity value is MIC = 0.32||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 0.64||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 1.28||Anti-Candida albicans MDM8, activity value is MIC = 0.32||Anti-Candida albicans MDM8, activity value is MIC = 2.56||Anti-Aerococcus viridans, activity value is MIC = 0.8||Anti-Bacillus cereus, activity value is MIC = 6.25||Anti-Bacillus megaterium, activity value is MIC = 0.2||Anti-Bacillus thuringiensis, activity value is MIC = 1.6||Anti-Enterococcus faecalis, activity value is MIC = 6.2||Anti-Listeria monocytogenes, activity value is MIC = 0.8||Anti-Micrococcus luteus, activity value is MIC = 0.4||Anti-Pediococcus acidolacrici, activity value is MIC = 3.15||Anti-Staphylococcus aureus, activity value is MIC = 1.6||Anti-Staphylococcus epidermidis, activity value is MIC = 0.8||Anti-Staphylococcus haemolyticus, activity value is MIC = 0.8||Anti-Staphylococcus saprophyticus, activity value is MIC = 0.8||Anti-Streptococcus pyogenes, activity value is MIC = 1.6||Anti-Nocardia asteroides, activity value is MIC = 1.6||Anti-Escherichia coli 1106, activity value is MIC = 0.8||Anti-Escherichia coli D22, activity value is MIC = 0.4||Anti-Escherichia coli D31, activity value is MIC = 0.8||Anti-Escherichia coli SBS363, activity value is MIC = 0.4||Anti-Erwinia carolovora, activity value is MIC = 3.15||Anti-Enterobacter cloacae β12, activity value is MIC = 3.15||Anti-Klebsiella pneumoniae, activity value is MIC = 3.15||Anti-Pseudomonas aeruginosa, activity value is MIC = 1.6||Anti-Salmonella thyphinurium, activity value is MIC = 0.8||Anti-Xhantomonas campestris pv. orizae, activity value is MIC = 3.15||Anti-Alternaria brassicola, activity value is MIC = 0.4||Anti-Aspergillus fumigatus, activity value is MIC = 1.6||Anti-Beauveria bassiana, activity value is MIC = 12.5||Anti-Fusarium culmorum, activity value is MIC = 0.4||Anti-Fusarium oxysporum, activity value is MIC = 0.4||Anti-Neurospora crassa, activity value is MIC = 0.4||Anti-Nectria haematococca, activity value is MIC = 0.2||Anti-Tricoderma viridae, activity value is MIC = 0.4||Anti-Tricophvton mentagrophytes, activity value is MIC = 0.8||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Antimalarial||Anticancer	Hemocytes, Acanthoscurria gomesiana|||Hemocytes, Acanthoscurria gomesiana|||Synthetic construct|||Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus)|||Hemocytes, Acanthoscurria gomesiana	Beta	"Using as control a
hemoglobin fragment (33–61 of bovine a-hemoglobin) (26),
which exhibits some effect on the viability of the parasite at
high concentrations (.40000 uM), gomesin was found to strongly
reduce viability even at concentration as low as 2500 uM. In
addition, in an hemolytic assay against human erythrocytes,
the percentage of cell lysis was found to be dependent of the
gomesin (amidated and non-amidated) concentrations tested.
From 100 uM (the lowest concentration tested) up to 200 uM, the
percentage of hemolysis remains rather low (,5%), whereas
increasing the peptide concentration up to 1000 uM results in a
rapid and significant elevation of the percentage of cell lysis (up
to approximately 16%). However, an increase in the concentra-tion
of gomesin of 2 orders of magnitude (final concentration
tested of 100000 uM) has only little effect on human eryhtrocyte
lysis|||Human erythrocytes (35% Hemolysis at 100 uM|||SK84 was hemolytic to both mouse and human erythrocytes, and only about 0.01% of the hemolysis rate was observed after 1 h incubation in the 1-100 uM concentration range (compared to 100% hemolysis induced by 0.2% Triton X-100).|||Human erythrocytes (35% Hemolysis at 100 uM|||25% hemolysis at 100 uM. Updated 5/2010; 2/2014; 5/2015; 7/2021 GW"	"Silva PI Jr, Daffre S, Bulet P.2000
 J Biol Chem. 2000 Oct 27;275(43):33464-70. PubMed.|||J Biol Chem
. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200.|||22865764|||J Biol Chem. 2000 Oct 27;275(43):33464-70.||Ref.10942757|||22865764|||J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200.|||J Biol Chem. 2000 Oct 27;275(43):33464-70. PubMed."	18	
FPDB00173	AP00192|||Hepcidin-20|||DRAMP03564|||Hepcidin-20|||AP00192|||DRAMP03564	ICIFCCGCCHRSKCGMCCKT	Anti-S. aureus, activity value is MIC = 5.38 ug/ml||Antibacterial ; Synthetic construct||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal||Antifungal ; E.coli ML35p||S. epidermidis||S. aureus||C. albicans||group B Streptococcus	Homo sapiens|||Synthetic construct|||Homo sapiens (Human)|||Homo sapiens|||Homo sapiens (Human)	Beta||Beta strand	N/A	Park CH, Valore EV, Waring AJ, Ganz T.2001 J Biol Chem. 2001 Mar 16;276(11):7806-10. PubMed.|||http://www.ncbi.nlm.nih.gov/protein/10863973|||J Biol Chem. 2001 Mar 16;276(11):7806-7810.|||11113131|||J Biol Chem. 2001 Mar 16;276(11):7806-10. doi: 10.1074/jbc.M008922200. Epub 2000 Dec 11.|||J Biol Chem. 2001 Mar 16;276(11):7806-7810.J Biol Chem. 2002 Oct 4;277(40):37597-37603.FEBS Lett. 2000 Sep 1;480(2-3):147-150.	20	
FPDB00174	AP00200|||AP00200|||CAMPSQ2743|||DRAMP03024	LKLKSIVSWAKKVL	Anti-Gram+ S. aureus CCRC12652, activity value is MIC = 96 ug/ml||Anti-S.aureus CCRC15211, activity value is MIC = 128 ug/ml||Anti-S. xylosus, activity value is MIC = 2 ug/ml||Anti-S. alactolyticus, activity value is MIC = 32 ug/ml||Anti-C. koseri, activity value is MIC = 6 ug/ml||Anti-E. coli BL21, activity value is MIC = 16 ug/ml||Anti-E. coli JM109 AmpR, activity value is MIC = 3 ug/ml||Anti-K.pneumoniae CCRC10694, activity value is MIC = 128 ug/ml||Anti-P.aeruginosa, activity value is MIC = 128 ug/ml||Anti-V. parahamelytics CCRC10806, activity value is MIC = 32||Anti-C. albicans ATCC 10231, activity value is MIC = 2.52 uM||Anti-C. albicans ATCC 2091, activity value is MIC = 2.52 uM||Anti-C. albicans ATCC 24433, activity value is MIC = 1.26 uM||Anti-C. albicans 1976R, activity value is MIC = 0.62 uM||Anti-C. albicans 2672R, activity value is MIC = 0.62 uM||Anti-C. tropicalis CT 1001, activity value is MIC = 0.62 uM||Anti-C. tropicalis CT 1002, activity value is MIC = 0.31 uM||Anti-C. tropicalis CT 1003, activity value is MIC = 1.24 uM||Anti-C. tropicalis CT 1004, activity value is MIC = 0.62 uM||Anti-C. tropicalis CT 1005, activity value is MIC = 0.62 uM||Anti-C. tropicalis CT 1006, activity value is MIC = 1.24 uM||Anti-C. tropicalis CT 1007, activity value is MIC = 1.24 uM||Anti-C. tropicalis CT 1008, activity value is MIC = 0.62 uM||Anti-C. tropicalis CT 1009, activity value is MIC = 0.62 uM||Anti-C. tropicalis CT 1010, activity value is MIC = 0.31 uM||Anti-C. parapsilosis CP 1001, activity value is MIC = 2.48 uM||Anti-C. parapsilosis CP 1002, activity value is MIC = 4.96 uM||Anti-C. parapsilosis CP 1003, activity value is MIC = 4.96 uM||Anti-C. parapsilosis CP 1004, activity value is MIC = 0.62 uM||Anti-C. parapsilosis CP 1005, activity value is MIC = 4.96 uM||Anti-C. parapsilosis CP 1006, activity value is MIC = 4.96 uM||Anti-C. parapsilosis CP 1007, activity value is MIC = 4.96 uM||Anti-C. parapsilosis CP 1008, activity value is MIC = 2.48 uM||Anti-C. parapsilosis CP 1009, activity value is MIC = 1.24 uM||Anti-C. parapsilosis CP 1010, activity value is MIC = 4.96 uM||Anti-C. glabrata CG 1001, activity value is MIC = 9.92 uM||Anti-C. glabrata CG 1002, activity value is MIC = 9.92 uM||Anti-C. glabrata CG 1003, activity value is MIC = 4.96 uM||Anti-C. glabrata CG 1004, activity value is MIC = 79.4 uM||Anti-C. glabrata CG 1005, activity value is MIC = 39.7 uM||Anti-C. glabrata CG 1007, activity value is MIC = 4.96 uM||Anti-C. glabrata CG 1008, activity value is MIC = 2.98 uM||Anti-C. glabrata CG 1009, activity value is MIC = 4.96 uM||Anti-C. glabrata CG 1010, activity value is MIC = 9.92 uM||Anti-Staphylococcus epidermidis ATTC 12228, activity value is MIC = 25 uM||Anti-Bacillus subtilis PCI 219, activity value is MIC = 25 uM||Anti-Enterococcus faecium EFMY-28, activity value is MIC = 12.5 uM||Anti-Escherichia coli NIHJ JC-2, activity value is MIC = 50 uM	Hornet, Vespa basalis|||Hornet, Vespa basalis|||Vespa basalis [Hornet]|||Vespa basalis (Hornet)	Helix||Alpha helix	[Ref.10667861] 68.2% hemolysis at the peptide concentration of 100 uM is , 27.9% Hemolysis at 50 uM against human red blood cells.	"Park NG, Yamato Y, Lee S, Sugihara G1995
 Biopolymers. 1995 Dec;36(6):793-801||for activity data, see AP2890 ref|||for activity data, see AP2890 ref|||8555423, 35209228||Refer Pubmed ID 35209228|||Ref.10667861"	14	
FPDB00175	AP00201|||AP00201|||CAMPSQ8243|||CAMPSQ9945|||DRAMP18665|||DRAMP18709	INLKALAALAKKIL	Anti-S. aureus ATCC 29213 or MRSA, activity value is MIC = 10||Anti-E. coli, activity value is MIC = 10||Anti-K. pneumoniae, activity value is MIC = 10||Anti-S. enterica, activity value is MIC = 10||Anti-Gram+ & Gram-||Anti-MRSA||Anticancer||Anti-Mastoparan analogue 9 : (A. baumannii strain CR17, activity value is MIC = 2.6 uM||Anti-A. baumannii strain CR86, activity value is MIC = 2.6 uM||Anti-A. baumannii strain Ab11, activity value is MIC = 1.3 uM||Anti-A. baumannii strain Ab113, activity value is MIC = 2.6 uM||Anti-A. baumannii strain CR86, activity value is MIC = 21 uM||Anti-A. baumannii strain Ab11, activity value is MIC = 42 uM||Anti-A. baumannii strain Ab113, activity value is MIC = 42 uM||Anti-E. coli, activity value is MIC = 32 uM||Anti-E. coli, activity value is MIC = 2 uM||Anti-S. aureus, activity value is MIC = 8 uM||Anti-P. aeruginosa PA14, activity value is MIC = 8 uM||Anti-P. aeruginosa PAO1, activity value is MIC = 8 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 25 uM||Anti-##Gram-negative bacteria: Escherichia coli ATCC 25922, activity value is MIC = 25 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 50 uM||Anti-Klebsiella pneumoniae ATCC 13883, activity value is MIC = 12.5 uM||Anti-Acinetobacter baumannii ATCC 19606, activity value is MIC = 2.7 uM||No MICs found in DRAMP database	Venom, Vespula lewisii|||Venom, Vespula lewisii, Asia (China/Japan)|||Venom, Vespula lewisii|||Synthetic construct|||Vespula lewisii|||Vespula lewisii (Korean yellow-jacket isp) (Vespula flaviceps lewisii)|||Vespula flaviceps lewisii (Korean yellow-jacket isp)	Helix||Alpha helix	Human RBCs [100% hemolysis at 45 uM]|||[Ref.27423268]40% hemolysis at 10 uM against rat red blood cells|||No hemolysis information or data found in the reference(s) presented in this entry	"García JR, Krause A, Schulz S, Rodríguez-Jiménez FJ, Klüver E, Adermann K, Forssmann U, Frimpong-Boateng A, Bals R, Forssmann WG1979
 Chem Pharm Bull (Tokyo). 1979 Aug;27(8):1942-4||Silva et al., 2020|||Chem Pharm Bull (Tokyo). 1979 Aug;27(8):1942-4|||Silva et al., 2020|||26114811|||31411881|||Biochim Biophys Acta. 2016 Nov;1858(11):2699-2708.||Ref.27423268|||Chem Pharm Bull (Tokyo). 1979 Aug;27(8):1942-4"	14	
FPDB00176	AP00204|||AP00204|||Nisin-Z	ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK	Anti-L. lactis MG1363, activity value is MIC = 0.02 ug/ml||Anti-L. monocytogenes LMG10470 or TT82E or LK132, activity value is MIC = 1.5||Anti-B. cereus CH-85, activity value is MIC = 6.25 ug/ml||Anti-S. aureus LMG10147 or LMG15975 or MRSA, activity value is MIC = 6.25 ug/ml||Anti-and E. faecium LMG11423 or LMG16003 or LMG16216, activity value is MIC = 3.13 ug/ml||Anti-Gram+||Antiviral||Anti-MRSA||Anticancer||Antibacterial	Lactococcus lactisNIZO 221 86|||Lactococcus lactisNIZO 221 86|||Lactococcus lactis  [Bacteria]	N/A	N/A	"Mulders JWM, Boerrigter IJ, Rollema HS, Siezen RJ, de Vos WM.1991
 Eur. J. Biochem. 1991; 201: 581-584|||Eur. J. Biochem. 1991; 201: 581-584|||28461263"	34	
FPDB00177	AP00205	ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK	Anti-l inhibitory activity was first reported in 1928. Active against Micrococcus spp, activity value is MIC = 1.1 ug/ml||Anti-Enterococcus spp, activity value is MIC = 16.7||Anti-Bacillus spp, activity value is MIC = 4.2||Anti-Clostridium spp, activity value is MIC = 1.1 ug/ml||Anti-A. viscosus, activity value is MIC = 83.6 ug/ml||Anti-P. acnes, activity value is MIC = 2.1||Anti-and Gram- bacteria: C. jejune, activity value is MIC = 1.1 ug/ml||Anti-H. influenzae, activity value is MIC = 66.9 ug/ml||Anti-H. pylori, activity value is MIC = 0.3 ug/ml||Anti-and Neisseria spp, activity value is MIC = 8.4 ug/ml||Anti-Gram+||Antiviral||Spermicidal||Anti-MRSA||Synergistic AMPs||Antibiofilm||Wound healing||Anticancer	Streptococcus lactis, reclassified as Lactococcus lactis	Nonhelixbeta	N/A	"Rogers, LA1928
 J. Bacteriol. 1928; 16:321-325. PubMed.||Ref see AP1003|||J. Bacteriol. 1928; 16:321-325. PubMed.|||J Bacteriol
. 1928 Nov;16(5):321-5. doi: 10.1128/jb.16.5.321-325.1928.||Ref see AP1003|||1928 Nov;16(5):321-5. doi: 10.1128/jb.16.5.321-325.1928.||Ref see AP1003"	34	
FPDB00178	AP00236	KSCCRNTWARNCYNVCRLPGTISREICAKKCDCKIISGTTCPSDYPK	Anti-Gram+ & Gram-||Hemolytic||Anticancer	nuts, Pyrularia pubera	Bridge	N/A	"Vernon LP, Evett GE, Zeikus RD., Gray WR.1985
 Arch. Biochem. Biophys. 1985; 238:18-29"	47	
FPDB00179	AP00247|||AP00247|||Caerin-1.8	GLFKVLGSVAKHLLPHVVPVIAEK	Anti-M. luteus, activity value is MIC = 6 ug/ml||Anti-S. aureusb, activity value is MIC = 6||Anti-S. epidermidis, activity value is MIC = 12 ug/ml||Anti-S. uberis, activity value is MIC = 25 ug/ml||Anti-B. cereus and P. multocida, activity value is MIC = 50 ug/ml||Anti-Gram+ & Gram-||Antifungal||Antiparasitic||Anticancer||Antibacterial	Blue-thighed frog, Litoria chloris, Australia|||Blue-thighed frog, Litoria chloris, Australia|||Litoria chloris [Blue-thighed frog]	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ.1998, Australia
 J. Pept. Res.1998; 51: 121-126. PubMed.|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||9516047|||J. Pept. Res.1998; 51: 121-126. doi: 10.1111/j.1399-3011.1998.tb00629.x."	24	
FPDB00180	AP00261|||DRAMP20793	GLFVGLAKVAAHNNPAIAEHFQA	Anti-B.cereus, activity value is MIC > 100 ug/ml||Anti-L.lactis, activity value is MIC > 100 ug/ml||Anti-L.innocua, activity value is MIC > 100 ug/ml||Anti-M.luteus, activity value is MIC > 100 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-S. uberis, activity value is MIC = 6 ug/ml||Anti-S.epidermidis, activity value is MIC > 100 ug/ml||Anti-S.faecalis, activity value is MIC > 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 6 ug/ml	Litoria genimaculate, Australia|||Litoria genimaculata (Green-eyed tree frog)	Helix	No hemolysis information or data found in the reference(s) presented in this entry	"Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.1998, Australia
 J. Pept. Sci. 1998; 4: 111-115. PubMed.|||Comparative Study J Pept Sci
. 1998 Apr;4(2):111-5. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||J. Pept. Sci. 1998 Apr; 4(2): 111-115.||Ref.9620615"	23	
FPDB00181	AP00262|||AP00262|||Maculatin-2.1|||Maculatin 2.1|||DRAMP01368	GFVDFLKKVAGTIANVVT	Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L.lactis, activity value is MIC > 100 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 100 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S. aureus, activity value is MIC = 100 ug/ml||Anti-S. epidermidis, activity value is MIC = 50 ug/ml||Anti-S.faecalis, activity value is MIC > 100 ug/ml||Anti-and S. uberis, activity value is MIC = 25 ug/ml||Antibacterial||Anti-Bacillus cereus, activity value is MIC = 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 25 ug/ml	Litoria genimaculate, Litoria eucnemis, Australia|||Litoria genimaculate, Litoria eucnemis, Australia|||Litoria genimaculata [Green-eyed tree frog]|||Litoria eucnemis|||Litoria genimaculata (brown-spotted treefrog)	N/A	N/A	"Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.1998, Australia
 J. Pept. Sci. 1998; 4: 111-115. PubMed.|||Comparative Study J Pept Sci
. 1998 Apr;4(2):111-5. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||9620615|||15203252|||Ref.2"	18	
FPDB00182	AP00263|||AP00263|||Maculatin-3.1|||DRAMP01369	GLLQTIKEKLESLESLAKGIVSGIQA	Anti-Specifically active against B.cereus, activity value is MIC > 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L.lactis, activity value is MIC > 100 ug/ml||Anti-L.innocua, activity value is MIC > 100 ug/ml||Anti-M.luteus, activity value is MIC > 100 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-S.aureus, activity value is MIC > 100 ug/ml||Anti-S.epidermidis, activity value is MIC > 100 ug/ml||Anti-S.faecalis, activity value is MIC > 100 ug/ml||Anti-and S. uberis, activity value is MIC = 25 ug/ml||Antibacterial||Antimicrobial||Anti-Gram+	Litoria genimaculate, Australia|||Litoria genimaculate, Australia|||Litoria genimaculata [Green-eyed tree frog]|||Litoria genimaculata (brown-spotted treefrog)	N/A	N/A	"Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.1998, Australia
 J. Pept. Sci. 1998; 4: 111-115. PubMed.|||Comparative Study J Pept Sci
. 1998 Apr;4(2):111-5. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||9620615|||J Pept Sci. 1998 Apr;4(2):111-115."	26	
FPDB00183	AP00281|||AP00281|||Cathelin-related antimicrobial peptide|||DRAMP03405|||AP00281	GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE	Anti-E. coli ATCC 25922 or ML35 or D21, activity value is MIC = 0.5||Anti-S. typhimurium ATCC 14028, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 4 uM||Anti-S. marcescens ATCC 8100, activity value is MIC = 4 uM||Anti-P-vulgaris ATCC 13315, activity value is MIC > 64 uM||Anti-S. aureus ATCC 25923 or Cowan I MRSA, activity value is MIC = 32||Anti-S. epidermidis ATCC 12228, activity value is MIC = 16 uM||Anti-S. faecalis ATCC 29212, activity value is MIC = 32 uM||Anti-B. megaterium Bm11, activity value is MIC = 4 uM||Anti-fumgi C-albicans, activity value is MIC > 64 uM||Anti-C. neoformans, activity value is MIC = 16 uM||Anti-and the single-stranded RNA virus respiratory syncytial virus . It also inhibit B. anthracis, activity value is MIC = 8 ug/ml||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-MRSA||Anticancer||Antibacterial||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 uM||Anti-Escherichia coli ML35, activity value is MIC = 2 uM||Anti-Escherichia coli D21, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 4 uM||Anti-Serratia marcescens ATCC 8100, activity value is MIC = 4 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 32 uM||Anti-Staphylococcus aureus Cowan I, activity value is MIC = 32 uM||Anti-Staphylococcus aureus, activity value is MIC > 64 uM||Anti-Staphylococcus aureus, activity value is MIC = 64 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 16 uM||Anti-Streptococcus faecalis ATCC 29212, activity value is MIC = 16 uM||Anti-Bacillus megaterium Bm11, activity value is MIC = 4 uM||Anti-Cryptococcus neoformans, activity value is MIC = 16 uM	precursor sequence homology, sequence alignment, other predictions|||precursor sequence homology, sequence alignment, other methods predicted|||precursor sequence homology, sequence alignment, other predictions|||Mus musculus [Mouse]|||Mus musculus (Mouse)|||precursor sequence homology, sequence alignment, other methods predicted	Helix||Alpha helix (CD)	CRAMP peptide does not lyse human or sheep red blood cell membranes at a concentration of 50 μM, but specific hemolytic values are not mentioned.|||CRAMP is also anticancer (tumor cells A549, K562, Jurkat, IC50 16-28 uM) with 2.2% hemolysis at 100 uM (little hemo.lytic). Change residue 2, 9, or 13 to K made CRAMP-18 anticancer as well but not better than its parent molecule. CRAMP also inactivates Zika virus (ZIKV). Updated 11/2015; 4/2016; 10/2016; 3/2023; seq corrected 5/2023; 6/2024.	"Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R.1997
 J. Biol. Chem. 1997: 272:13088-13093. PubMed||Blower et al., 2018||Archer NK et al., 2016|||J. Biol. Chem. 1997: 272:13088-13093. PubMed|||J Biol Chem
. 1997 May 16;272(20):13088-93. doi: 10.1074/jbc.272.20.13088.||Blower et al., 2018||Archer NK et al., 2016|||9148921|||FEBS Lett. 1996 Aug 5;391(1-2):5-8.|||J. Biol. Chem. 1997: 272:13088-13093. PubMed||Blower et al., 2018||Archer NK et al., 2016|||1997 May 16;272(20):13088-93. doi: 10.1074/jbc.272.20.13088.||Blower et al., 2018"	33	
FPDB00184	AP00303|||AP00303|||Tigerinin-1|||DRAMP01350|||Tigerinin-1|||AP00303|||DRAMP01350	FCTMIPIPRCY	Anti-B. subtilis, activity value is MIC = 30 ug/ml||Anti-S. aureus ATCC 8530, activity value is MIC = 30 ug/ml||Anti-E. coli W 160.37, activity value is MIC = 40 ug/ml||Anti-P. putida NCIM 2102, activity value is MIC = 40 ug/ml||Anti-M. luteus MT 166, activity value is MIC = 20 ug/ml||Anti-and yeast S. cerevisiae ATCC 8530, activity value is MIC = 80 ug/ml||Anti-including A549, activity value is IC50 = 27.4 uM||Anti-MCF-7, activity value is IC50 = 29.6 uM||Anti-PC3, activity value is IC50 = 49.7 uM||Anti-and HepG2, activity value is IC50 = 35.7 uM||Anti-E. coli, activity value is MIC = 40 ug/ml||Anti-S. cerevisiae ATCC 8530, activity value is MIC = 80 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 30 ug/ml||Anti-Staphylococcus aureus ATCC 8530, activity value is MIC = 30 ug/ml||Anti-Micrococcus luteus MT 166, activity value is MIC = 20 ug/ml||Anti-Escherichia coli, activity value is MIC = 40 ug/ml||Anti-Pseudomonas putida NCIM 2102, activity value is MIC = 40 ug/ml	skin secretions, Rana tigerina, India, Asia|||skin secretions, Rana tigerina, India, Asia|||Synthetic construct|||Rana sakuraii (Japanese brown frog)|||Rana tigerina (Indian bull frog)|||Hoplobatrachus tigerinus|||skin secretions, Rana tigerina, India, Asia|||Rana tigerina (Indian bull frog)	N/A	[Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 ug/ml against rat erythrocytes.	"Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N.2001
 J. Biol. Chem. 2001; 276:2701-2707. PubMed|||J Biol Chem
. 2001 Jan 26;276(4):2701-7. doi: 10.1074/jbc.M006615200. Epub 2000 Oct 12.|||11031261|||J Biol Chem. 2001 Jan 26;276(4):2701-2707.|||11031261|||https://pubmed.ncbi.nlm.nih.gov/11031261|||J. Biol. Chem. 2001; 276:2701-2707. PubMed"	11	
FPDB00185	AP00308|||1420|||AP00308|||Buforin-2|||BF2|||DRAMP01163|||Buforin-2|||AP00308|||DRAMP01163	TRSSRAGLQFPVGRVHRLLRK	Anti-Gram+ bacteria B. subtilis, activity value is MIC = 2 ug/ml||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-S. mutans, activity value is MIC = 2 ug/ml||Anti-S. pneumoniae, activity value is MIC = 4 ug/ml||Anti-P. putida, activity value is MIC = 2 ug/ml||Anti-E. coli, activity value is MIC = 4 ug/ml||Anti-S. typhimurium, activity value is MIC = 1 ug/ml||Anti-Serratia sp, activity value is MIC = 4 ug/ml||Anti-C. albicans, activity value is MIC = 1 ug/ml||Anti-C. neoformans, activity value is MIC = 1 ug/ml||Anti-and S. cerevisiae, activity value is MIC = 1 ug/ml||5% Cytotoxicity at 0.5 ug/ml||Anti-ctive against Gram+ bacteria B. subtilis, activity value is MIC = 2 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||Anti-Streptococcus mutans, activity value is MIC = 2 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 4 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 2 ug/ml||Anti-Escherichia coli, activity value is MIC = 4 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 1 ug/ml||Anti-Candida albicans, activity value is MIC = 1 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 1 ug/ml||Antibacterial||Anti-Saccharomyces cerevisiae, activity value is MIC = 1 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||anti-sepsis||Anticancer	derivative of buforin I after treatment with endoproteinase, protease digestion|||derivative of buforin I after treatment with endoproteinase, protease digestion|||Bufo gargarizans [Asian toad]|||Sphaenorhynchus lacteus [Orinoco lime treefrog]|||Bufo gargarizans (Asian toad) (Bufo bufo gargarizans)|||derivative of buforin I after treatment with endoproteinase, Sequence truncation, animal-derived, natural derivative|||Bufo gargarizans (Asian toad) (Bufo bufo gargarizans)	Helix||Alpha helix	Human RBCs (<50% hemolysis at 6.25-200 uM)	"Park CB, Kim MS, Kim SC.1996
 Biochem. Biophys. Res. Commun. 1996; 218:408-413||Lee 2008 Cancer Lett 271: 47-51|||Biochem. Biophys. Res. Commun. 1996; 218:408-413||Lee 2008 Cancer Lett 271: 47-51|||Lee 2008 Cancer Lett 271: 47-51|||8573171|||30044391|||Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.|||8573171|||Biochem. Biophys. Res. Commun. 1996; 218:408-413||Lee 2008 Cancer Lett 271: 47-51|||Biochem. Biophys. Res. Commun. 1996; 218:408-413"	21	L
FPDB00186	AP00339|||AP00339|||Chrysophsin-1	FFGWLIKGAIHAGKAIHGLIHRRRH	Anti-Gram+ L. garvieae YT-3, activity value is MIC = 10 uM||Anti-S. iniae F-8502, activity value is MIC = 2.5 uM||Anti-V. anguillarum ATCC 19264, activity value is MIC = 2.5 uM||Anti-Vibriopenaeicida KHA, activity value is MIC = 10 uM||Anti-V. harveyi HUFP911 1, activity value is MIC = 2.5 uM||Anti-V. vulnificus ET-7617, activity value is MIC = 5 uM||Anti-A-hydrophila ET-4, activity value is MIC > 40 uM||Anti-A. salmonicida NCMB 1102, activity value is MIC = 10 uM||Anti-P. putida ATCC 12633, activity value is MIC = 40 uM||Anti-and E-tarda ET-82016, activity value is MIC > 40 uM||Antibacterial	the pyloric caeca and gills; Red sea bream, Chrysophrys major or Pagrus major|||the pyloric caeca and gills; Red sea bream, Chrysophrys major or Pagrus major|||Pagrus major [Red sea bream]	Helix	N/A	"Iijima N, Tanimoto N, Emoto Y, Morita Y, Uematsu K, Murakami T, Nakai T.2003
 Eur. J. Biochem. 2003; 270:675-686. PubMed.|||Comparative Study Eur J Biochem
. 2003 Feb;270(4):675-86. doi: 10.1046/j.1432-1033.2003.03419.x.|||12581207"	25	
FPDB00187	AP00351|||1421|||1422|||4030|||4031|||4032|||4033|||4034|||4035|||4036|||4037|||4038|||AP00351|||Citropin-1.1|||AMP-001/Cit 1.1|||AMP-003|||Cit1.1|||Citropin 1.1|||AMP-001/Cit 1.1|||AP00351	GLFDVIKKVASVIGGL	Anti-L. lactis, activity value is MIC = 3||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-S. epidermidis, activity value is MIC = 12||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-S. uberis, activity value is MIC = 12 ug/ml||Anti-S. aureus or MRSA, activity value is MIC = 25 ug/ml||Anti-B. cereus, activity value is MIC = 25||Anti-and B. subtilis, activity value is MIC = 12.5 ug/ml||Anti-Gram+ E. faecalis PCM 2673, activity value is MIC = 32 ug/ml||Anti-S. aureus ATCC 25923 or 9144, activity value is MIC = 16 ug/ml||Anti-S. pneumoniae ATCC 49619, activity value is MIC = 32 ug/ml||Anti-E. coli ATCC 25922 or 23506, activity value is MIC = 32 ug/ml||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 16 ug/ml||Anti-P.aeruginosa ATCC 9027, activity value is MIC = 128 ug/ml||Anti-A. niger ATCC 16404, activity value is MIC = 64 ug/ml||Anti-C.albicans ATCC 10231, activity value is MIC = 128 ug/ml||Anti-and C.glabrata ATCC 15126, activity value is MIC = 128 ug/ml||60% Cytotoxicity at 0.5 ug/ml||activity value is IC50 = 5000000 uM||Anti-Gram+ & Gram-||Antifungal||Anti-MRSA||Anti-inflammatory||Enzyme inhibitor||Antibiofilm||Anticancer||Anti-Bacillus cereus, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 6 ug/ml||Anti-Listeria innocua, activity value is MIC = 25 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus JE2 MRSA, activity value is MIC = 32 ug/ml||Anti-Escherichia coli K12, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus ATCC 43300 MRSA, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus JE2 MRSA, activity value is MIC = 256 ug/ml||Anti-Escherichia coli K12, activity value is MIC = 256 ug/ml||Anti-E. coli, activity value is MIC = 10 uM||Anti-E. coli, activity value is MIC = 5 uM||Anti-K. pneumoniae, activity value is MIC = 20 uM||Anti-MRSA, activity value is MIC = 10 uM||Anti-S. aureus, activity value is MIC = 3 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 16 ug/ml||Antibacterial	skin secretion, Australian blue mountains tree frog, Litoria citropa|||skin secretion, Australian blue mountains tree frog, Litoria citropa|||Litoria citropa|||Synthetic construct|||Synthetic construct|||skin secretion, Australian blue mountains tree frog, Litoria citropa	Helix	Human RBCs [HC50 = > 32 ug/ml]|||Mouse RBCs [Hemolysis (%) = 16.5 ± 3 uM]|||Human RBCs [HC50 = > 32 ug/ml]	"Wegener KL., Wabnitz PA., Carver JA., Bowie JH., Chia BCS., Wallace JC., Tyler MJ.1999, Australia
 Eur. J. Biochem. 1999; 265: 627-637. PubMed.||Calabrese AN et al., 2012||Neubauer et al., 2017|||Eur. J. Biochem. 1999; 265: 627-637. PubMed.|||Comparative Study Eur J Biochem
. 1999 Oct;265(2):627-37. doi: 10.1046/j.1432-1327.1999.00750.x.||Calabrese AN et al., 2012||Neubauer et al., 2017|||10504394|||31336137|||31448597|||30043322|||31336137|||Eur. J. Biochem. 1999; 265: 627-637. PubMed.||Calabrese AN et al., 2012||Neubauer et al., 2017"	16	L
FPDB00188	AP00352|||AP00352|||Citropin-1.2|||DRAMP01594	GLFDIIKKVASVVGGL	Anti-L. lactis, activity value is MIC = 3 ug/ml||Anti-S. uberis, activity value is MIC = 12 ug/ml||Anti-S. epidermidis and S. aureus, activity value is MIC = 25 ug/ml||Anti-Gram+||Antifungal||Anticancer||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 25 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 12 ug/ml	Australian blue mountains tree frog, Litoria citropa|||Australian blue mountains tree frog, Litoria citropa|||Litoria citropa|||Litoria citropa (Australian blue mountains tree frog)	N/A	N/A	"Wegener KL., Wabnitz PA., Carver JA., Bowie JH., Chia BCS., Wallace JC., Tyler MJ.1999, Australia Eur. J. Biochem. 1999; 265: 627-637. PubMed.|||Comparative Study Eur J Biochem
. 1999 Oct;265(2):627-37. doi: 10.1046/j.1432-1327.1999.00750.x.|||10504394|||Eur. J. Biochem. 1999; 265: 627-637. PubMed.|||Ref.2"	16	
FPDB00189	AP00353|||AP00353|||Citropin-1.3|||DRAMP01600	GLFDIIKKVASVIGGL	Anti-L. lactis, activity value is MIC = 6 ug/ml||Anti-S. uberis, activity value is MIC = 12 ug/ml||Anti-S. epidermidis and S. aureus, activity value is MIC = 25 ug/ml||Anti-Gram+||Antifungal||Anticancer||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 6 ug/ml||Anti-Listeria innocua, activity value is MIC = 25 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 25 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 25 ug/ml	Australian blue mountains tree frog, Litoria citropa|||Australian blue mountains tree frog, Litoria citropa|||Litoria citropa|||Litoria citropa (Australian blue mountains tree frog)	N/A	N/A	"Wegener KL., Wabnitz PA., Carver JA., Bowie JH., Chia BCS., Wallace JC., Tyler MJ.1999, Australia
 Eur. J. Biochem. 1999; 265: 627-637. PubMed.|||Comparative Study Eur J Biochem
. 1999 Oct;265(2):627-37. doi: 10.1046/j.1432-1327.1999.00750.x.|||10504394|||Eur. J. Biochem. 1999; 265: 627-637. PubMed.|||Ref.2"	16	
FPDB00190	AP00366|||AP00366|||Antibacterial peptide BMAP-27|||DRAMO02855|||Antibacterial peptide BMAP-27|||AP00366	GRFKRFRKKFKKLFKKLSPVIPLLHLG	Anti-E. coli ATCC 25922 ML-35 or D21, activity value is MIC = 0.5||Anti-S. typhimurium ATCC 14028, activity value is MIC = 1||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-S. marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-S. aureus ATCC 25923 or Cowan 1 MRSA, activity value is MIC = 2||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1 uM||Anti-B. megaterium Bm11, activity value is MIC = 2 uM||Anti-C. albicans, activity value is MIC = 8 uM||Anti-and C. neoformans, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 1 uM||Anti-E. coli ML35, activity value is MIC = 1 uM||Anti-E.coli D21, activity value is MIC = 0.25 uM||Anti-S. typhimurium ATCC 14028, activity value is MIC = 1 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2 uM||Anti-S. aureus Cowan 1, activity value is MIC = 2 uM||Anti-S. aureus MRSA, activity value is MIC = 4 uM||Anti-C.albicans, activity value is MIC = 8 uM||Anti-C.neoformans, activity value is MIC = 4 uM||Anti-E.coli(LOG 2, activity value is MIC = 3.75||Anti-Escherichia coli ATCC25922, activity value is MIC = 1 ug/ml||Anti-E. coli ML35, activity value is MIC = 1 ug/ml||Anti-E. coli D21, activity value is MIC = 0.25 ug/ml||Anti-Salmonella typhimurium ATCC 14028, activity value is MIC = 1 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1 ug/ml||Anti-Serratia marcescens ATCC 8100, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus Cowan 1, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1 ug/ml||Anti-Bacillus megaterium Bm11, activity value is MIC = 2 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 4 ug/ml	cattle, Bos taurus|||cattle, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine)|||Bos taurus [Bovine]|||cattle, Bos taurus	Helix	"The hemolytic activity of the two BMAPs was much lower,
when measured on bovine erythrocytes (data not shown). These
cells were 5–10-fold less susceptible than human red blood cells
to BMAP-28 (3, 6, and 22% hemolysis at 10, 30, and 100000 uM
peptide), and virtually unaffected by BMAP-27 even at 100000 uM.
We speculate that the different susceptibility of human and
bovine red blood cells to these molecules may be accounted for
by species-specific differences in the erythrocyte membrane
composition, and may reflect the need to protect the host cells
from undesired cytotoxic effects. We have also noted that the
effects of BMAP-28 on the cell membranes are consistently
higher than BMAP-27, in spite of the structural similarity of
the two molecules, thus suggesting that minor structural dif-ferences
can modulate the activity of these peptides.|||The document explicitly mentions the hemolytic values of two novel antimicrobial peptides (BMAP-27, BMAP-28) and their derivatives (BMAP-27(1–18), BMAP-28(1–18), mBMAP-28) on human red blood cells. The core data are as follows: 
 
1. Hemolytic properties of parent peptides (BMAP-27, BMAP-28).
 
 BMAP-28 (for human red blood cells): 
 At a concentration of 3 μM, the hemolysis rate is 14.5%; 
 At a concentration of 100 μM, the hemolysis rate exceeds 90% (specifically 94.1%). 
 BMAP-27 (against human red blood cells): 
 At a concentration of 3 μM, the hemolysis rate is only 3.5%; 
 At a concentration of 100 μM, the hemolysis rate is 32.7%. 
 Its hemolytic effect on bovine red blood cells is significantly lower than that of human red blood cells: 
 BMAP-28 had hemolytic rates of 3%, 6%, and 22% at concentrations of 10 uM, 30 uM, and 100 uM, respectively; 
 BMAP-27 has almost no hemolytic effect on bovine red blood cells even at a concentration of 100 uM. 
 
2. Hemolytic properties of truncated derivatives (BMAP-27(1–18), BMAP-28(1–18)).
 
The hemolytic effect of truncated peptides (retaining only 18 residues at the N-terminus and removing the hydrophobic tail at the C-terminus) is significantly reduced: 
 
BMAP-27 (1–18): Has almost no hemolytic activity against human red blood cells (Figure 6 shows no significant hemolytic rate; combined with text description of ""hemolytic effect disappears""). 
BMAP-28(1–18): hemolytic rate of human red blood cells is significantly lower than that of parent peptides (the curve in Figure 6 is close to baseline, no specific value, but the text clearly states ""hemolytic effect greatly reduced""). 
 
3. Hemolytic properties of modified derivatives (mBMAP-28).
 
Significant loss of hemolytic activity in mBMAP-28 (replacement of hydrophobic residues at the C-terminal for hydrophilic residues): 
 
At a concentration of 100 μM, the hemolytic rate for human red blood cells is only 3.3%, far lower than the 94.1% of the parent peptide BMAP-28. 
 
Additional notes
 
Hemolysis detection method: Using standard hemolysis experiments, 10% (v/v) red blood cell suspension and peptides of different concentrations were incubated at 37°C for 15 minutes to measure absorbance at 415nm, using complete hemolysis induced by 0.2% Triton X-100 as a 100% control. 
Relationship between hemolysis and antibacterial activity: The hemolytic concentration of parental peptides (≥3 uM) is much higher than that of their antibacterial activity concentration (MIC: 0.25–4 uM); Truncated/modified derivatives retain antibacterial activity while significantly reducing hemolytic activity and improving targeted selectivity.|||The document clearly mentions the hemolytic values of BMAP-27, BMAP-28, and their analogues (truncated or modified forms) on human and bovine red blood cells. The core data are as follows:

I. Hemolytic values for human red blood cells (key indicators)

Measured by standard hemolysis experiments, presented as ""peptide concentration (uM) - hemolysis rate (%)"", the results are the average of multiple independent experiments (S.E. ≤1.8):

1. BMAP-28
3 uM: 14.5%
100 uM: >90% (specifically 94.1%)
2. BMAP-27
3 uM: 3.5%
100 uM: 32.7%
3. Truncated forms: BMAP-27(1–18), BMAP-28(1–18)
BMAP-27(1–18): nearly no hemolytic activity (no specific value given, only mentioned as ""hemolytic effect disappeared"").
BMAP-28(1–18): hemolytic activity significantly reduced (no specific concentration-hemolysis correspondence given, only mentioned as ""declined markedly"").
4. Modified form: mBMAP-28 (hydrophobic residues at C-terminus replaced with hydrophilic residues)
100 uM: only 3.3% hemolysis (much lower than parent BMAP-28's 94.1%).

II. Hemolytic values for bovine red blood cells (species difference comparison)

Bovine red blood cells are significantly less sensitive to BMAPs than human red blood cells:

1. BMAP-28
10 uM: 3%
30 uM: 6%
100 uM: 22%
2. BMAP-27
100 uM: virtually no hemolysis (""virtually unaffected"").

III. Supplementary notes

Hemolysis experiment conditions: 10% (v/v) red blood cell suspension in pH 7.4 PBS, incubated with peptides at 37 °C for 15 minutes, with complete hemolysis induced by 0.2% Triton X-100 as the 100% control.
Trend: The hemolytic activity of peptides is mainly mediated by the hydrophobic domain at the C-terminus—removal (truncated forms) or modification (mBMAP-28) of this region significantly reduces hemolysis, but antibacterial activity (MIC) is largely retained.|||BMAP-28 can cause 14.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate exceeds 90% at 100 μM. 
BMAP-27 can cause 3.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate is 32.7% at 100 μM. 
Cow red blood cells are 5-10 times less sensitive to BMAP-28 than human red blood cells, with hemolysis rates of 3%, 6%, and 22% at concentrations of 10 μM, 30 μM, and 100 μM, respectively; BMAP-27 shows almost no hemolytic effect on cow red blood cells at 100 μM. 
The hemolytic effect of the truncated analog BMAP-27(1-18) disappears, and the hemolytic effect of BMAP-28(1-18) is greatly reduced. 
The modified analog mBMAP-28 has a hemolysis rate of only 3.3% for human red blood cells at 100 μM, far lower than the 94.1% of the parent peptide BMAP-28.|||BMAP-27 shows lower toxicity, with a hemolysis rate of only 3.5% at 3 uM and 32.7% at 100 uM.|||human RBC: HC50>100 uM (3.5% hemolysis at 3 uM; 32.7% hemolysis at 100 uM), but not hemo.lytic to bovine RBC even at 100 uM. Thus, hemolysis is related to cell sources, indicating the need of protecting the host from lysis."	"Skerlavaj B., Gennaro R., Bagella L., Merluzzi L, Risso A, Zanetti M.1996
 J. Biol. Chem. 1996; 271: 28375-28381. PubMed.||Xia et al., 2024|||J. Biol. Chem. 1996; 271: 28375-28381. PubMed.|||J Biol Chem
. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375.||Xia et al., 2024|||8910461, 29103679||Refer PubMed ID: 29103679|||J Biol Chem. 1996 Nov 8;271(45):28375-28381.|||8910461, 29103679||Refer PubMed ID: 29103679|||J. Biol. Chem. 1996; 271: 28375-28381. PubMed.||Xia et al., 2024"	27	
FPDB00191	AP00367|||AP00367|||Cathelicidin-5 , Antibacterial peptide BMAP-28 , Myeloid antibacterial peptide 28|||DRAMO02854|||Cathelicidin-5 , Antibacterial peptide BMAP-28 , Myeloid antibacterial peptide 28|||AP00367	GGLRSLGRKILRAWKKYGPIIVPIIRIG	Anti-E. coli ATCC 25922 ML-35 or D21, activity value is MIC = 0.5||Anti-S. typhimurium ATCC 14028, activity value is MIC = 1 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-S. marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-S. aureus ATCC 25923 or Cowan 1 MRSA, activity value is MIC = 1||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1 uM||Anti-B. megaterium Bm11, activity value is MIC = 1 uM||Anti-C. albicans, activity value is MIC = 8 uM||Anti-and C. neoformans, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Anti-MRSA||Hemolytic||Antibiofilm||Anticancer||Anti-E. coli ATCC 25922, activity value is MIC = 2 uM||Anti-E. coli ML35, activity value is MIC = 2 uM||Anti-E. coli D21, activity value is MIC = 0.5 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2 uM||Anti-S. aureus Cowan 1, activity value is MIC = 1 uM||Anti-S. aureus, activity value is MIC = 4 uM||Anti-B. megaterium Bm11, activity value is MIC = 2 uM||Anti-C. neoformans, activity value is MIC = 4 uM||Anti-E.coli(LOG 2, activity value is MIC = 5.80||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2 uM||Anti-Salmonella typhimurium ATCC 14028, activity value is MIC = 1 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-Serratia marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2 uM||Anti-Staphylococcus aureus Cowan 1, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 1 uM||Anti-Bacillus megaterium Bm11, activity value is MIC = 2 uM||Anti-Cryptococcus neoformans, activity value is MIC = 4 uM	peripheral neutrophils; cattle, Bos taurus|||peripheral neutrophils; cattle, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine)|||Bos taurus [Bovine]|||peripheral neutrophils; cattle, Bos taurus	Helix	"The hemolytic activity of the two BMAPs was much lower,
when measured on bovine erythrocytes (data not shown). These
cells were 5–10-fold less susceptible than human red blood cells
to BMAP-28 (3, 6, and 22% hemolysis at 10, 30, and 100000 uM
peptide), and virtually unaffected by BMAP-27 even at 100000 uM.
We speculate that the different susceptibility of human and
bovine red blood cells to these molecules may be accounted for
by species-specific differences in the erythrocyte membrane
composition, and may reflect the need to protect the host cells
from undesired cytotoxic effects. We have also noted that the
effects of BMAP-28 on the cell membranes are consistently
higher than BMAP-27, in spite of the structural similarity of
the two molecules, thus suggesting that minor structural dif-ferences
can modulate the activity of these peptides.|||The document explicitly mentions the hemolytic values of two novel antimicrobial peptides (BMAP-27, BMAP-28) and their derivatives (BMAP-27(1–18), BMAP-28(1–18), mBMAP-28) on human red blood cells. The core data are as follows: 
 
1. Hemolytic properties of parent peptides (BMAP-27, BMAP-28).
 
 BMAP-28 (for human red blood cells): 
 At a concentration of 3 μM, the hemolysis rate is 14.5%; 
 At a concentration of 100 μM, the hemolysis rate exceeds 90% (specifically 94.1%). 
 BMAP-27 (against human red blood cells): 
 At a concentration of 3 μM, the hemolysis rate is only 3.5%; 
 At a concentration of 100 μM, the hemolysis rate is 32.7%. 
 Its hemolytic effect on bovine red blood cells is significantly lower than that of human red blood cells: 
 BMAP-28 had hemolytic rates of 3%, 6%, and 22% at concentrations of 10 uM, 30 uM, and 100 uM, respectively; 
 BMAP-27 has almost no hemolytic effect on bovine red blood cells even at a concentration of 100 uM. 
 
2. Hemolytic properties of truncated derivatives (BMAP-27(1–18), BMAP-28(1–18)).
 
The hemolytic effect of truncated peptides (retaining only 18 residues at the N-terminus and removing the hydrophobic tail at the C-terminus) is significantly reduced: 
 
BMAP-27 (1–18): Has almost no hemolytic activity against human red blood cells (Figure 6 shows no significant hemolytic rate; combined with text description of ""hemolytic effect disappears""). 
BMAP-28(1–18): hemolytic rate of human red blood cells is significantly lower than that of parent peptides (the curve in Figure 6 is close to baseline, no specific value, but the text clearly states ""hemolytic effect greatly reduced""). 
 
3. Hemolytic properties of modified derivatives (mBMAP-28).
 
Significant loss of hemolytic activity in mBMAP-28 (replacement of hydrophobic residues at the C-terminal for hydrophilic residues): 
 
At a concentration of 100 μM, the hemolytic rate for human red blood cells is only 3.3%, far lower than the 94.1% of the parent peptide BMAP-28. 
 
Additional notes
 
Hemolysis detection method: Using standard hemolysis experiments, 10% (v/v) red blood cell suspension and peptides of different concentrations were incubated at 37°C for 15 minutes to measure absorbance at 415nm, using complete hemolysis induced by 0.2% Triton X-100 as a 100% control. 
Relationship between hemolysis and antibacterial activity: The hemolytic concentration of parental peptides (≥3 uM) is much higher than that of their antibacterial activity concentration (MIC: 0.25–4 uM); Truncated/modified derivatives retain antibacterial activity while significantly reducing hemolytic activity and improving targeted selectivity.|||The document clearly mentions the hemolytic values of BMAP-27, BMAP-28, and their analogues (truncated or modified forms) on human and bovine red blood cells. The core data are as follows:

I. Hemolytic values for human red blood cells (key indicators)

Measured by standard hemolysis experiments, presented as ""peptide concentration (uM) - hemolysis rate (%)"", the results are the average of multiple independent experiments (S.E. ≤1.8):

1. BMAP-28
3 uM: 14.5%
100 uM: >90% (specifically 94.1%)
2. BMAP-27
3 uM: 3.5%
100 uM: 32.7%
3. Truncated forms: BMAP-27(1–18), BMAP-28(1–18)
BMAP-27(1–18): nearly no hemolytic activity (no specific value given, only mentioned as ""hemolytic effect disappeared"").
BMAP-28(1–18): hemolytic activity significantly reduced (no specific concentration-hemolysis correspondence given, only mentioned as ""declined markedly"").
4. Modified form: mBMAP-28 (hydrophobic residues at C-terminus replaced with hydrophilic residues)
100 uM: only 3.3% hemolysis (much lower than parent BMAP-28's 94.1%).

II. Hemolytic values for bovine red blood cells (species difference comparison)

Bovine red blood cells are significantly less sensitive to BMAPs than human red blood cells:

1. BMAP-28
10 uM: 3%
30 uM: 6%
100 uM: 22%
2. BMAP-27
100 uM: virtually no hemolysis (""virtually unaffected"").

III. Supplementary notes

Hemolysis experiment conditions: 10% (v/v) red blood cell suspension in pH 7.4 PBS, incubated with peptides at 37 °C for 15 minutes, with complete hemolysis induced by 0.2% Triton X-100 as the 100% control.
Trend: The hemolytic activity of peptides is mainly mediated by the hydrophobic domain at the C-terminus—removal (truncated forms) or modification (mBMAP-28) of this region significantly reduces hemolysis, but antibacterial activity (MIC) is largely retained.|||BMAP-28 can cause 14.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate exceeds 90% at 100 μM. 
BMAP-27 can cause 3.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate is 32.7% at 100 μM. 
Cow red blood cells are 5-10 times less sensitive to BMAP-28 than human red blood cells, with hemolysis rates of 3%, 6%, and 22% at concentrations of 10 μM, 30 μM, and 100 μM, respectively; BMAP-27 shows almost no hemolytic effect on cow red blood cells at 100 μM. 
The hemolytic effect of the truncated analog BMAP-27(1-18) disappears, and the hemolytic effect of BMAP-28(1-18) is greatly reduced. 
The modified analog mBMAP-28 has a hemolysis rate of only 3.3% for human red blood cells at 100 μM, far lower than the 94.1% of the parent peptide BMAP-28.|||At 3 uM, the hemolysis rate of BMAP-28 is 14.5%, and it exceeds 90% at 100 uM.|||The document mentions experimental results related to hemolysis, as follows:

- Hemolytic effect of BMAP-28 on human red blood cells: at a concentration of 3 µM, 14.5% of cells were lysed; at 100 µM, more than 90% of cells were lysed.

- Hemolytic effect of BMAP-27 on human red blood cells: at a concentration of 3 µM, 3.5% of cells were lysed; at 100 µM, 32.7% of cells were lysed.

- Hemolytic effect of BMAP-28 on bovine red blood cells: at concentrations of 10 µM, 30 µM, and 100 µM, 3%, 6%, and 22% of cells were lysed, respectively.

- Hemolytic effect of BMAP-27 on bovine red blood cells: even at a concentration of 100 µM, bovine red blood cells were almost unaffected.

- Hemolytic effect of BMAP-28(1-18) on human red blood cells: hemolytic activity was significantly reduced (specific values were not clearly listed).

- Hemolytic effect of BMAP-27(1-18) on human red blood cells: completely lost hemolytic activity.

- Hemolytic effect of mBMAP-28 on human red blood cells: at a concentration of 100 µM, only 3.3% of cells were lysed.|||Human RBC: HC50 < 100 uM (at 100 uM, 90% hemolysis). However, lower hemolysis to bovine RBC BMAP-28 (3, 6, and 22% hemolysis at 10, 30, and 100000 uM peptide)."	"Skerlavaj B., Gennaro R., Bagella L., Merluzzi L, Risso A, Zanetti M.1996
 J. Biol. Chem. 1996; 271: 28375-28381. PubMed.|||J. Biol. Chem. 1996; 271: 28375-28381. PubMed.|||J Biol Chem
. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375.|||8910461, 29103679||Refer PubMed ID: 29103679|||J Biol Chem. 1996 Nov 8;271(45):28375-28381.|||8910461, 29103679||Refer PubMed ID: 29103679|||J. Biol. Chem. 1996; 271: 28375-28381. PubMed."	28	
FPDB00192	AP00393|||AP00393|||Penaeidin-2a|||DRAMP02571|||AP00393|||DRAMP02571	YRGGYTGPIPRPPPIGRPPFRPVCNACYRLSVSDARNCCIKFGSCCHLVK	Anti-M. luteus, activity value is MIC = 2.5||Anti-E-coli 363, activity value is MIC > 40 uM||Anti-F. oxysporum, activity value is MIC = 5||Anti-S.cerevisiae TGY, activity value is MIC > 100 uM||Anti-Gram+ & Gram-||Antifungal||Anticancer||Antibacterial||Antifungal ; Micrococcus luteus||Escherichia coli 363||Fusarium Oxysporum||Saccharomyces cerevisiae TGY||Antimicrobial||Anti-Gram+||Anti-Gram-	plasma and hemocytes, Penoeid shrimp, Penaeus vannamei = Litopenaeus vannamei|||plasma and hemocytes, Penoeid shrimp, Penaeus vannamei = Litopenaeus vannamei|||Litopenaeus vannamei [Whiteleg shrimp]|||Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)|||plasma and hemocytes, Penoeid shrimp, Penaeus vannamei = Litopenaeus vannamei|||Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)	N/A	N/A	"Destoumieux D, Bulet P, Loew D, Van Dorsselaer A, Rodriguez J, Bachère E. 1997
 J Biol Chem. 1997 Nov 7;272(45):28398-406. doi: 10.1074/jbc.272.45.28398. PubMed.|||J Biol Chem
. 1997 Nov 7;272(45):28398-406. doi: 10.1074/jbc.272.45.28398.|||11028917|||Cell Mol Life Sci. 2000 Aug;57(8-9):1260-1271.|||J Biol Chem. 1997 Nov 7;272(45):28398-406. doi: 10.1074/jbc.272.45.28398. PubMed.|||Cell Mol Life Sci. 2000 Aug;57(8-9):1260-1271. J Biol Chem. 1997 Nov 7;272(45):28398-28406. Eur J Biochem. 1999 Dec;266(2):335-346."	50	
FPDB00193	AP00396|||Antibacterial protein PR-39	RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP	Anti-and B. subtilis . lethal conc=LC. Also: Active against Gram- bacteria B-cereus ATCC 10876, activity value is MIC > 32 ug/ml||Anti-E. coli ATCC 25922, activity value is MIC = 5 uM||Anti-A. Baumannii, activity value is MIC = 2.5 uM||Anti-P. aeruginosa ATCC 27853 or PAO1, activity value is MIC = 2.5||Anti-S-aureus MRSA, activity value is MIC > 40 uM||Anti-B. Globigii, activity value is MIC = 5 uM||Anti-and L. Monocytogenes, activity value is MIC = 10 uM||Antibacterial	Pig neutrophils; Sus scrofa|||Sus scrofa [Pig]	Rich	N/A	"Agerberth B, Lee JY, Bergman T, Carlquist M, Boman HG, Mutt V, Jörnvall H.1991
 Eur J Biochem. 1991 Dec 18;202(3):849-54. PubMed.||PMID:30641213||Pashaie et al., 2025|||1765098"	39	
FPDB00194	AP00427|||AP00427|||XT-7|||DRAMP02136|||AP00427	GLLGPLLKIAAKVGSNLL	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer||Anti-L. plantarum WCFS1, activity value is MIC = 128 ug/ml||Anti-L. rhamnosus LGG, activity value is MIC = 64 ug/ml||Anti-L. salivarius DSM20554, activity value is MIC = 128 ug/ml||Anti-L. salivarius FortaFit Ls-33, activity value is MIC = 250 ug/ml||Anti-L. casei R0215, activity value is MIC = 64 ug/ml||Anti-L. casei Shirota, activity value is MIC = 64 ug/ml||Anti-L. johnsonii LC-1, activity value is MIC = 128 ug/ml||Anti-L. reuteri ATCC5730, activity value is MIC = 64 ug/ml||Anti-L. acidophilus LA5, activity value is MIC = 64 ug/ml||Anti-S. suis S10, activity value is MIC = 32 ug/ml||Anti-S. aureus DMS20231, activity value is MIC = 16 ug/ml||Anti-S. aureus Sens 8325.4, activity value is MBC = 64 ug/ml||Anti-S. aureus MRSA B33424, activity value is MIC = 8 ug/ml||Anti-S. pseudintermedium E138, activity value is MIC = 8 ug/ml||Anti-S. pseudintermedium E139, activity value is MBC = 32 ug/ml||Anti-S. pseudintermedium E140, activity value is MBC = 16 ug/ml||Anti-S. pseudintermedium S70E2, activity value is MBC = 64 ug/ml||Anti-P. aeruginosa Sens 2 ATCC27853, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa MDR1 B38084, activity value is MIC = 256 ug/ml||Anti-P. aeruginosa MDR2 B31770, activity value is MIC = 32 ug/ml||Anti-E. faecium Sens S1, activity value is MIC = 256 ug/ml||Anti-E. faecium Sens S2, activity value is MIC = 64 ug/ml||Anti-E. faecium VanA R39, activity value is MIC = 8 ug/ml||Anti-E. faecium VanB R44, activity value is MIC = 16 ug/ml||Anti-A. baumannii MDR Bangl 027, activity value is MIC = 256 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 1.7 uM||Anti-S. aureus ATCC25923, activity value is MIC = 4.7 uM||Anti-E. coli ML35p, activity value is MIC = 3 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 25 uM||Anti-S. aureus multiresistant ATCCBAA-44, activity value is MIC = 1.6 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 6.3 uM||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-Escherichia coli, activity value is MIC = 5 uM||Anti-Candida albicans, activity value is MIC = 40 uM||Anti-Staphylococcus aureus, activity value is MIC = 7 uM||Anti-Staphylococcus epidermidis 1420129, activity value is MIC = 3 uM||Anti-S. saprophyticus 1950556, activity value is MIC = 13 uM||Anti-Escherichia coli 25922, activity value is MIC = 6 uM||Anti-Streptococcus group C 1541035, activity value is MIC = 3 uM||Anti-Shigella sonnei 1840187, activity value is MIC = 35 uM||Anti-Pseudomonas aeruginosa 0380972, activity value is MIC = 60 uM||Anti-Enterobacter cloacae 1441323, activity value is MIC = 35 uM	Diploid clawed frog Silurana tropicalis, (formerly) Xenopus tropicalis , Africa|||Diploid clawed frog Silurana tropicalis, (formerly) Xenopus tropicalis , Africa|||Silurana tropicalis|||Xenopus tropicalis [Western clawed frog]|||Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)|||Diploid clawed frog Silurana tropicalis, (formerly) Xenopus tropicalis , Africa	Helix	"The abilities of the peptides isolated in this study
to inhibit the growth of the Gram-positive bacterium
S. aureus, the Gram-negative bacterium E. coli and
the yeast C. albicans and to lyse human erythrocytes
are compared in Table 1. The ability of a synthetic
replicate of peptide XT-7 to inhibit the growth of a
range of microorganisms from clinical isolates is
shown in Table 2. The MIC values for the free
acid form of XT-7 are 60 WM against E. coli, 130
WM against S. aureus and s 200 WM against C. albi-cans.
The peptide showed no hemolytic activity at
concentrations up to 400 WM. Synthetic des-Lys8-
XT-7 was inactive against S. aureus and E. coli at
concentrations up to 200 WM.|||The hemolytic data explicitly mentioned in the document (with 50% hemolysis concentration (HC₅₀) as the core indicator) are as follows, covering both natural peptides and synthetic analogs:

1. Natural antimicrobial peptides (XT-1 to XT-7)

Hemolytic data are clearly recorded for only three peptides; the remaining peptides were either not tested (ND) or have no recorded hemolytic activity. Details are as follows:

XT-1: HC₅₀ against human red blood cells not detected (ND).
XT-7: HC₅₀ against human red blood cells = 70 μM, the only natural peptide with clearly noted hemolytic activity.
XT-5, XT-6: HC₅₀ against human red blood cells both >150 μM, hemolytic activity is very weak.
XT-2, XT-3, XT-4: No specific hemolytic values mentioned; it is inferred from antimicrobial activity tests that there is no significant hemolytic activity recorded.

2. Synthetic analogs of XT-7

By modifying the structure of XT-7 (reducing cationicity), its hemolytic activity changed significantly:

XT-7 free acid (C-terminal -COOH replaced with -CONH₂): Even at concentrations up to 400 μM, no hemolytic activity was observed against human red blood cells.
des-Lys⁸-XT-7 (lacking Lys⁸ residue): Specific HC₅₀ not mentioned, but since antimicrobial activity is completely lost (no activity against Staphylococcus aureus or E. coli at concentrations >200 μM), it is inferred that its hemolytic activity is also very low or absent.

Note: All hemolytic experiments were conducted on human red blood cells, with HC₅₀ calculated by comparing to 100% hemolysis induced by 1% Tween 20 under incubation at 37 °C for 1 hour.|||Among the seven antimicrobial peptides secreted by the skin (XT-1 to XT-7), some peptides exhibit hemolytic activity against human erythrocytes. Their hemolytic values (HC₅₀, the peptide concentration causing 50% hemolysis) are as follows:

- XT-1: 90 µM
- XT-7: 70 µM
- XT-2, XT-4, XT-5, XT-6: No hemolytic activity was observed at the tested concentrations (up to 150 µM or 400 µM), marked as "">153"" or not determined (ND).|||Rat RBCs [HC50 = 110 uM]|||In Biochimica et Biophysica Acta 2001, among the antimicrobial peptides isolated from the skin secretions of the tropical clawed frog (Xenopus tropicalis), XT-1 had an HC₅₀ of 90 μM against human red blood cells, XT-7 had an HC₅₀ of 70 μM against human red blood cells, the hemolytic activity of XT-2 was not measured, and XT-4, XT-5, and XT-6 all had an HC₅₀ greater than 150 μM against human red blood cells.|||HC₅₀=70"	"ALI MF., SOTO A., KNOOP FC., CONLON JM.2001
 Biochim Biophys Acta 2001 Nov 26;1550(1):81-9. PubMed.|||Biochim Biophys Acta 2001 Nov 26;1550(1):81-9. PubMed.|||Biochim Biophys Acta
. 2001 Nov 26;1550(1):81-9. doi: 10.1016/s0167-4838(01)00272-2.|||31102497|||33932712, 23094651, 11738090||Refer PubMed ID 23094651|||Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.|||Biochim Biophys Acta 2001 Nov 26;1550(1):81-9. PubMed."	18	
FPDB00195	AP00429|||AP00429|||Antimicrobial peptide NK-lysin|||DRAMP02980|||AP00429	GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE	Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||anti-sepsis||Antimalarial||Anticancer||Anti-Escherichia coli D21, activity value is MIC = 8 uM||Anti-Bacillus megaterium, activity value is MIC = 0.8 uM||Anti-moderate PIG Escherichia coli Bd2221/75, activity value is MIC = 39 uM||Anti-Streptococcus pyogeneis, activity value is MIC = 34 uM||Anti-Candida albicans, activity value is MIC = 31 uM||Anti-with medium E]: Escherichia coli D21, activity value is MIC = 0.5 uM||Anti-Escherichia coli Bd2221/75, activity value is MIC = 10 uM||Anti-Acinetobacter calcoaceticus Ac 11, activity value is MIC = 7 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 1.6 uM||Anti-Escherichia coli Bd2221/75, activity value is MIC = 39 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 0.8 uM||Anti-Streptococcus pyogenes w.t, activity value is MIC = 34 uM||Anti-Candida albicans w.t, activity value is MIC = 31 uM	cytotoxic T and NK cells, small intestine, domestic pig Sus scrofa|||ytotoxic T and NK cells, small intestine, domestic pig Sus scrofa|||cytotoxic T and NK cells, small intestine, domestic pig Sus scrofa|||Sus scrofa [pig]|||Sus scrofa (Pig)|||cytotoxic T and NK cells, small intestine, domestic pig Sus scrofa	Helix||Alpha helix	1	"Andersson M, Gunne H, Agerberth B, Boman A, Bergman T, Sillard R, Jörnvall H, Mutt V, Olsson B, Wigzell H, et al. 1995
 EMBO J. 1995 Apr 18;14(8):1615-25. PubMed.|||1995 Apr 18;14(8):1615-25. doi: 10.1002/j.1460-2075.1995.tb07150.x.|||EMBO J
. 1995 Apr 18;14(8):1615-25. doi: 10.1002/j.1460-2075.1995.tb07150.x.|||7737114|||EMBO J. 1995 Apr 18;14(8):1615-1625.|||EMBO J. 1995 Apr 18;14(8):1615-25. PubMed.|||EMBO J. 1995 Apr 18;14(8):1615-25. PubMed."	78	
FPDB00196	AP00485|||AP00485|||Cupiennin-1|||DRAMP03222	GFGALFKFLAKKVAKTVAKQAAKQGAKYVVNKQME	Anti-and E. faecalis ATCC 29212, activity value is MIC = 2.5||activity value is IC50 = 0.658||Anti-T. brucei rhodesiense, activity value is IC50 = 0.055||Anti-and P. falciparum, activity value is IC50 = 0.029||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-||Insecticidal	venom, Cupiennius salei|||venom, Cupiennius salei|||Cupiennius salei [Wandering spider]|||Cupiennius salei (Wandering spider)	Helix||Alpha helix (3 helices; 11 residues)	"In hemolysis experiments targeting the antimicrobial peptide Cupiennin 1 from spider venom, the relevant hemolytic values (peptide concentration causing 50% hemolysis, EC₅₀) are as follows:

- Cupiennin 1a: 24.4 µM (95% confidence interval 22.9–26 µM).
- Cupiennin 1a (non-amidated)*: 20.5 µM (95% confidence interval 19.4–21.8 µM).
- Cupiennin 1d (non-amidated)*: 14.5 µM (95% confidence interval 14.4–14.7 µM).
- Cupiennin 1b: Hemolysis rate was 15% at 8 µM, EC₅₀ was not explicitly determined, but activity is higher than Cupiennin 1a and lower than Cupiennin 1d.

Compared with other peptides, the hemolytic activity of Cupiennin 1 is lower than that of bee venom peptide (Melittin, EC₅₀ = 1.7 µM), but higher than that of magainin 2 (which has no hemolytic activity).|||[Ref.11792701]EC50=24.4 uM against human red blood cells."	"Kuhn-Nentwig L, Muller J, Schaller J, Walz A, Dathe M, Nentwig W2002
 J Biol Chem. 2002 Mar 29;277(13):11208-16. PubMed.|||J Biol Chem
. 2002 Mar 29;277(13):11208-16. doi: 10.1074/jbc.M111099200. Epub 2002 Jan 15.|||11792701|||Biochemistry. 2007 Mar 20;46(11):3576-3585."	35	
FPDB00197	AP00506|||1709|||CAMPSQ21943	KLAKLAKKLAKLAK	Anticancer||LC50 =< 50 uM||Anti-Acinetobacter baumannii ATCC 19606, activity value is MIC = 300 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 150 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 300 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 150 ug/ml||Anti-Pseudomonas aeruginosa PA14, activity value is MIC = 150 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 300 ug/ml||Anti-Mucor circinelloides, activity value is MIC = 300 ug/ml||Anti-Mucor circinelloides, activity value is MFC = 600 ug/ml||Anti-Mucor circinelloides, activity value is MIC = 600 ug/ml||Anti-Rhizopus oryzae, activity value is MIC = 300 ug/ml||Anti-Rhizopus oryzae, activity value is MFC = 600 ug/ml||Anti-Rhizopus homothallicus, activity value is MIC = 300 ug/ml||Anti-Rhizopus homothallicus, activity value is MFC = 600 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 300 ug/ml||Anti-Pseudomonas aeruginosa NCGM2.S1, activity value is MIC = 300 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC > 300 ug/ml||Anti-Pseudomonas aeruginosa PAO4290, activity value is MIC = 300 ug/ml||Anti-Acinetobacter baumannii ATCC 15308, activity value is MIC = 300 ug/ml||Anti-Acinetobacter baumannii, activity value is MIC = 64||Anti-Escherichia coli ATCC 25922, activity value is MIC > 300 ug/ml||Anti-Escherichia coli, activity value is MIC = 64 ug/ml||Anti-Klebsiella pneumoniae ATCC 15380, activity value is MIC > 128 ug/ml||Anti-Klebsiella pneumoniae ATCC BAA-2146, activity value is MIC > 128 ug/ml||Anti-Serratia marcescens NBRC 102204, activity value is MIC > 256 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 128 ug/ml||Anti-Human hepatocellular carcinoma HepG2, activity value is LD50 > 256 ug/ml||Anti-Bacillus subtilis PS832, activity value is MIC = 0.5 uM||Anti-Bacillus subtilis PS832, activity value is MIC = 0.25 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 4 uM||Anti-Escherichia coli DL7, activity value is MIC = 1 uM||Anti-Klebsiella aerogenes ATCC 13048, activity value is MIC > 32 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 6 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6 uM||Anti-Escherichia coli ATCC 25922, activity value is MBC = 10 uM	KLA sequence repeats, de novo designed based on sequence motif, man-made sequences|||Synthetic construct	N/A	Human erythrocytes (10% Hemolysis at 64 uM, Human erythrocytes (<10% Hemolysis at >750 uM	"Mai JC, Mi Z, Kim SH, Ng B, Robbins PD.
 Cancer Res 2001 Nov 1;61(21):7709-12|||23345420, 26734838, 24098573, 33335804, 8759631"	14	L
FPDB00198	AP00513|||AP00513|||Ranalexin|||DRAMP01355|||Ranalexin|||AP00513|||DRAMP01355	FLGGLIKIVPAMICAVTKKC	Anti-active as the WT against S. aureus or MRSA, activity value is MIC = 4 ug/ml||Anti-P.aeruginosa, activity value is MIC = 128 ug/ml||Anti-E. coli, activity value is MIC = 32 ug/ml||Anti-Gram+ & Gram-||Antifungal||Antiparasitic||Anti-MRSA||Synergistic AMPs||Anticancer||Antibacterial ; Rana catesbeiana||Anti-S.aureus, activity value is MIC = 4 ug/ml||Anti-E.coli, activity value is MIC = 32 ug/ml||Anti-Bacillus megaterium DSM 32, activity value is MIC = 1.9 uM||Anti-B. subtilis DSM 10, activity value is MIC = 1.9 uM||Anti-Clostridium pasterianum DSM 525, activity value is MIC = 7.6 uM||Anti-Corynebacterium spheniscorum DSM 44757, activity value is MIC = 7.6 uM||Anti-Enterococcus casseliflavus ATCC 700327 VanC 1, activity value is MIC = 3.8 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 7.6 uM||Anti-E. faecium UL4070742 VanA 3, activity value is MIC = 7.6 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.8 uM||Anti-S. aureus NCTC 10442 MRSA 4, activity value is MIC = 3.8 uM||Anti-S. epidermidis ATCC 14990, activity value is MIC = 7.6 uM||Anti-S. saprophyticus ATCC 15305, activity value is MIC = 3.8 uM||Anti-Acinetobacter baumannii SC3033362 4-MRGN 5, activity value is MIC = 1.9 uM||Anti-A. baumannii SC3223332 4-MRGN 5, activity value is MIC = 3.8||Anti-A. baumannii SC4111902 4-MRGN 5, activity value is MIC = 1.9 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 15.2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 30.4 uM||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||Anti-Escherichia coli, activity value is MIC = 32 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 128 ug/ml	Bull frog, Rana catesbeiana, North America|||Bull frog, Rana catesbeiana, North America|||Rana catesbeiana|||Rana catesbeiana [American bullfrog]|||Rana sakuraii (Japanese brown frog)|||Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)|||Bull frog, Rana catesbeiana, North America|||Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)	Helix	"The document does not provide the half-hemolytic concentration (HC₅₀) of each peptide directly, but hemolytic activity is reflected through the percentage of hemolysis. The core data are as follows:

1. Hybrid Peptides (RN7-IN series)

RN7-IN10: At a concentration of 15.62 µg/ml, the hemolysis rate is 5.9%; no hemolytic activity is observed at its minimum inhibitory concentration (MIC = 7.81–15.62 µg/ml).
RN7-IN9, RN7-IN8, RN7-IN6: At a concentration of 15.62 µg/ml, the hemolysis rate is 0.0%; no hemolytic activity is observed at each respective MIC.
RN7-IN7: No hemolytic toxicity observed even at the highest tested concentration of 250 µg/ml (hemolysis rate 0.0%).

2. Indolicidin Analogs (IN series)

IN1: At a concentration of 250 µg/ml, the hemolysis rate is 3.6%; no hemolytic activity at its MIC (31.25–62.5 µg/ml).
IN2: At 250 µg/ml, hemolysis rate is 15.39%; no hemolytic activity at its MIC.
IN3: At 250 µg/ml, hemolysis rate is 2.39%; no hemolytic activity at its MIC (62.5 µg/ml).
IN4: Specific hemolysis data are not mentioned, but the document notes weak activity against Streptococcus pneumoniae (MIC = 250 µg/ml), suggesting low hemolysis risk at effective concentrations.

3. Parent Peptides

Indolicidin: At 20 µg/ml, hemolysis rate reaches 56.98%, showing the strongest hemolytic toxicity among all peptides.
Ranalexin: At 250 µg/ml, hemolysis rate is <15%, with hemolytic toxicity lower than Indolicidin.

The above data were measured by human red blood cell hemolysis experiments: a 4% human red blood cell suspension was incubated with peptides at 1.95–250 µg/ml at 37 °C for 1 hour, with PBS as a negative control (0% hemolysis) and 0.1% Triton X-100 as a positive control (100% hemolysis). Hemolysis rates were calculated based on absorbance at 560 nm. All peptides showed no cytotoxicity or hemolytic effects at their MIC values, and only some peptides exhibited slight hemolysis at concentrations far above their MICs.|||In hemolysis experiments targeting the antimicrobial peptide Ranalexin in the skin of the American bullfrog (Rana catesbeiana), Ranalexin can cause hemolysis of human red blood cells at concentrations up to 500 ug/ml, indicating that it has a certain degree of hemolytic activity, but the specific hemolysis rate or HC₅₀ value is not clearly stated in the document.|||S.aureus ( MIC = 4 ug/ml), E.coli ( MIC = 32 ug/ml), P.aeruginosa ( MIC = 128 ug/ml)|||In the study of antimicrobial peptides from the skin of Brazilian frog Phyllomedusa distincta), the hemolysis of Dermadistinctins series of peptides is different. DD L starts to show hemolytic activity at a concentration of 12.5 uM, while the remaining peptides (DD K, M, Q1, Q2) need to be more than 32 uM to produce hemolysis, of which the hemolysis rate of DD K, Q1, Q2 is still not significantly increased above 32 uM, showing low hemolysis"	"Clark DP, Durell S, Maloy WL, Zasloff M1994
 J Biol Chem 1994; 269: 10849-10855. (Clark et al., 1994)|||J Biol Chem 1994; 269: 10849-10855. (Clark et al., 1994)|||J Biol Chem
. 1994 Apr 8;269(14):10849-55.|||https://pubmed.ncbi.nlm.nih.gov/8144672|||31426494|||J Biol Chem. 2001 Jan 26;276(4):2701-2707.|||8144672|||J Biol Chem 1994; 269: 10849-10855. (Clark et al., 1994)"	20	
FPDB00199	AP00540|||AP00540|||Ocellatin-P1|||DRAMP01182	GLLDTLKGAAKNVVGSLASKVMEKL	Anti-E. coli ATCC 25922, activity value is MIC = 25 uM||Anti-E. cloacae HNTCC 53001, activity value is MIC = 50 uM||Anti-Streptococcus Group B HNTCC 80130, activity value is MIC = 50 uM||Anti-K. pneumoniae KK3 9904, activity value is MIC = 100 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 100 uM||Anti-S. epidermidis RP62A, activity value is MIC = 100 uM||Escherichia coli||Enterobacter cloacae||Klebsiella pneumoniae||Pseudomonas aeruginosa||Staphylococcus aureus||Staphylococcus epidermidis||Enterococcus faecalis||Streptococcus group B||Anti-Escherichia coli ATCC 25922, activity value is MIC = 25 uM||Anti-Klebsiella pneumoniae KK3 9904, activity value is MIC = 100 uM||Anti-Enterobacter cloacae HNTCC 53001, activity value is MIC = 50 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 100 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 100 uM	South American bullfrog, Leptodactylus pentadactylus, skin secretion, Leptodactylus labyrinthicus|||South American bullfrog, Leptodactylus pentadactylus, skin secretion, Leptodactylus labyrinthicus|||Leptodactylus pentadactylus [Smokey jungle frog]|||Leptodactylus pentadactylus (South American bullfrog)	N/A	LD50>400 AM|||The document reports the results of a hemolysis assay: pentadactylin exhibits very low hemolytic activity against human red blood cells, with a half-maximal hemolytic concentration (LD₅₀) greater than 400 µM; at a concentration of 400 µM, the hemolysis rate is 29%.|||Human erythrocytes (LD50 > 400 uM )	"King JD, Al-Ghaferi N, Abraham B, Sonnevend A, Leprince J, Nielsen PF, Conlon JM2005
 Comp Biochem Physiol C Toxicol Pharmacol. 2005 Aug;141(4):393-7.|||Comp Biochem Physiol C Toxicol Pharmacol. 2005 Aug;141(4):393-7.|||16236555"	25	
FPDB00200	AP00541|||AP00541|||CAMPSQ25	IDWKKLLDAAKQIL	Anti-G+ and G- bacteria such as E. coli, activity value is MIC = 5 uM||Anti-S. aureus, activity value is MIC = 9 uM||Anti-and B. cereus, activity value is MIC = 5 uM||Anti-and P. aeruginosa, activity value is MIC = 5 uM||Anti-B. subtilis CCT 2576, activity value is MIC = 4 ug/ml||Anti-S. aureus ATCC 6538, activity value is MIC = 15 ug/ml||Anti-E. coli ATCC 25922, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa ATCC 15422, activity value is MIC = 8 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Chemotactic||Anticancer	venom, social wasp, Polybia paulista|||venom, social wasp, Polybia paulista|||Vespa magnifica [Hornet]|||venom, social wasp, Polybia paulista, Brazil, Paraguay, and Argentina, South America	Helix	"Polybia-MPIpresented no hemolytic activity, while Polybia-CP presenteda very reduced hemolysis at 10−5000000 uM, but caused 78% hemol-ysis
at the concentration of 10−4000000 uM.|||The document mentions the hemolytic activity results of two peptides:

- Polybia-MPI: No hemolytic activity was observed within the experimental concentration range (up to 10^{-4} M).
- Polybia-CP: Hemolytic activity was very low at 10^{-5} M, and at 10^{-4} M, it caused 78% hemolysis of red blood cells.|||It still exhibits no hemolytic activity at a concentration of 10⁻⁴ M."	"Souza BM, Mendes MA, Santos LD, Marques MR, Cesar LM, Almeida RN, Pagnocca FC, Konno K, Palma MS2005
 Peptides. 2005 Nov;26(11):2157-64. Pub-Med.||Wang K et al. 2014|||Peptides
. 2005 Nov;26(11):2157-64. doi: 10.1016/j.peptides.2005.04.026. Epub 2005 Aug 29.||Wang K et al. 2014|||16129513|||Peptides. 2005 Nov;26(11):2157-64. Pub-Med.||Wang K et al. 2014|||Peptides. 2005 Nov;26(11):2157-64. Pub-Med."	14	
FPDB00201	AP00565|||AP00565|||Brevinin-1DYe , Dybowskin-2|||Brevinin-1DYe , Dybowskin-2|||AP00565|||DRAMP01249	FLIGMTQGLICLITRKC	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||Anti-E.coli, activity value is MIC = 15 uM||Anti-S. aureus, activity value is MIC = 30 uM||Anti-Staphylococcus aureus, activity value is MIC = 15 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 25 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 50 ug/ml||Anti-Escherichia coli, activity value is MIC = 60 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 60 ug/ml||Anti-Candida albicans, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 3.3 uM||Anti-S. aureus, activity value is MIC = 7.9 uM||Anti-B. subtilis, activity value is MIC = 13.1 uM||Anti-S. epidermidis, activity value is MIC = 13.1 uM||Anti-S. dysenteriae, activity value is MIC = 26.2 uM||Anti-E. coli, activity value is MIC = 31.4 uM||Anti-K. pneumoniae, activity value is MIC = 31.4 uM||Anti-P.mirabilis, activity value is MIC > 100 ug/ml||Anti-P.aeruginosa, activity value is MIC > 100 ug/ml||Anti-and C. albicans, activity value is MIC = 100 ug/ml||Anti-S. lactis and E. coli, activity value is MIC = 12.8||Anti-Micrococcus luteus ATCC4698, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus KCTC3881, activity value is MIC = 15 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis ATCC12228, activity value is MIC = 25 ug/ml||Anti-Shigella dysenteriae ATCC9752, activity value is MIC = 50 ug/ml||Anti-Escherichia coli KCTC2433, activity value is MIC = 60 ug/ml||Anti-Klebsiella pneumoniae ATCC10031, activity value is MIC = 60 ug/ml||Anti-Proteus mirabilis ATCC25933, activity value is MIC > 100 ug/ml||Anti-Candida albicans ATCC36232, activity value is MIC = 100 ug/ml	Rana dybowskii, Rana chensinensis, Asia|||Rana dybowskii, Rana chensinensis, Asia|||Rana dybowskii|||Rana dybowskii (Korea brown frog)	N/A	"Such a strong hydrophobic property may lead to
indiscriminant membrane perturbation that would in turn
explain its high hemolytic activity (47.58%).|||The document mentions content related to hemolysis. The specific hemolysis values are as follows:

- Dybowskin-1: Hemolysis rate is 0.99%.
- Dybowskin-2: Hemolysis rate is 10.99%.
- Dybowskin-3: Hemolysis rate is 1.86%.
- Dybowskin-4: Hemolysis rate is 47.58%.
- Dybowskin-5: Hemolysis rate is 17.84%.
- Dybowskin-6: Hemolysis rate is 59.40%.|||hRBC (10.99% hemolysis at 100 ug/ml)|||hRBC (10.99% hemolysis at 100 ug/ml)|||At the test concentration of 100 ug/ml, the hemolysis rate of Dybowskin-2 on human red blood cells is 10.99%.|||[Ref:17698251] It has 10.99% hemolytic activity at 100 ug/ml against human red blood cells|||Showed ~11% hemolysis at (100 ug/ml peptide to 10% human RBCs, v/v)."	"Kim SS, et al. Lee BJ2007
 Peptides 2007; 28: 1532-1539. PubMed|||Peptides
. 2007 Aug;28(8):1532-9. doi: 10.1016/j.peptides.2007.07.002. Epub 2007 Jul 7.|||17688900 , 17698251||Refer PubMed ID: 17698251000000|||17688900 , 17698251||Refer PubMed ID: 17698251000000|||Peptides 2007; 28: 1532-1539. PubMed.||ref see AP605|||Ref.17698251|||Peptides 2007; 28: 1532-1539. PubMed."	17	
FPDB00202	AP05249	DDNPNENDNPDSKPDDSSKNPEPGFPKFLSILGSEIIENAVDFILRSMSRGSSFMELEGDPGQQPSKVT	active against E. coli DH5alpha||V. cholerae||and P. aeruginosa. Also showed effects on multiple cancer cells.	Mus musculus	N/A	N/A	Zhong K, Wang Y, Wang Z, Zhang Z, Zhao S, Li H, Huang J, Guo W, Zheng X, Guo G, Zhou L, Yang H, Tong A. 2021 Biomolecules. 2021 Mar 24;11(4):485. doi: 10.3390/biom11040485. PubMed	69	
FPDB00203	AP05186	FLKGLMGVIASLFK	Anti-Gram+ S. aureus NCTC 13277 MRSA, activity value is MIC = 6.25 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 1.56 uM||Anti-S. typhi ATCC 14028, activity value is MIC = 50 uM||Anti-E. coli ATCC 25922, activity value is MIC = 25 uM||Anti-P. aeruginosa ATCC 10145, activity value is MIC = 50 uM||Anti-and fungi C. albicans ATCC 36082, activity value is MIC = 15.6 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer	sequence extension, designed, man-made sequences	Helix	a hemolysis HC50 value of 90 uM|||NST-2(1): 90.0 uMRNST-2(2): 13.8 uMRSP-1(3): 51.0 uMRLFP-1(4): 98.9 uMRLFP-2(5): 25.0 uMRLFP-3(6): 6.6 uMRSP-4(7): >100 uMRLFP-4(8): 4.5 uM|||human RBC: HC50 51 uM. Hemolytic.	Abdullah SJ, Guan JS, Mu Y, Bhattacharjya S.2024 Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213.|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed	14	
FPDB00204	AP05185	FLKKLMGVIASLF	Anti-Gram+ S. aureus NCTC 13277 MRSA, activity value is MIC = 50 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 12.5 uM||Anti-S. typhi ATCC 14028, activity value is MIC = 100 uM||Anti-E. coli ATCC 25922, activity value is MIC = 50 uM||Anti-P.aeruginosa ATCC 10145, activity value is MIC = 200 uM||Anti-and fungi C. albicans ATCC 36082, activity value is MIC = 100 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anticancer	amino acid substitution, designed, man-made sequences	Helix	a hemolysis HC50 value of 90 uM|||NST-2(1): 90.0 uMRNST-2(2): 13.8 uMRSP-1(3): 51.0 uMRLFP-1(4): 98.9 uMRLFP-2(5): 25.0 uMRLFP-3(6): 6.6 uMRSP-4(7): >100 uMRLFP-4(8): 4.5 uM|||human RBC: HC50 >100 uM (not hemo.lytic at 100 uM).	Abdullah SJ, Guan JS, Mu Y, Bhattacharjya S.2024 Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213.|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed	13	
FPDB00205	AP05184	" 
FLKGLMGVIASLF"	Anti-Gram+ S. aureus NCTC 13277 MRSA, activity value is MIC = 3.12 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 1.56 uM||Anti-S. typhi ATCC 14028, activity value is MIC = 50 uM||Anti-E. coli ATCC 25922, activity value is MIC = 50 uM||Anti-P.aeruginosa ATCC 10145, activity value is MIC = 200 uM||Anti-and fungi C. albicans ATCC 36082, activity value is MIC = 15.6 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer	sequence reversal, designed, man-made sequences|||Source: sequence reversal, designed, man-made sequences	Helix	a hemolysis HC50 value of 90 uM|||NST-2(1): 90.0 uMRNST-2(2): 13.8 uMRSP-1(3): 51.0 uMRLFP-1(4): 98.9 uMRLFP-2(5): 25.0 uMRLFP-3(6): 6.6 uMRSP-4(7): >100 uMRLFP-4(8): 4.5 uM|||human RBC: HC50 13.8 uM; hemolytic.	Abdullah SJ, Guan JS, Mu Y, Bhattacharjya S.2024 Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213.|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed	13	
FPDB00206	AP05183	" 
FLSAIVGMLGKLF"	Anti-Gram+ S. aureus NCTC 13277 MRSA, activity value is MIC = 14.34 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 6.25 uM||Anti-S.typhi ATCC 14028, activity value is MIC = 250 uM||Anti-E.coli ATCC 25922, activity value is MIC = 125 uM||Anti-P.aeruginosa ATCC 10145, activity value is MIC > 250 uM||Anti-and fungi C. albicans ATCC 36082, activity value is MIC = 20 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer	amino acid substitution, amphibians, animal-derived, natural derivative	Helix	a hemolysis HC50 value of 90 uM|||NST-2(1): 90.0 uMRNST-2(2): 13.8 uMRSP-1(3): 51.0 uMRLFP-1(4): 98.9 uMRLFP-2(5): 25.0 uMRLFP-3(6): 6.6 uMRSP-4(7): >100 uMRLFP-4(8): 4.5 uM|||human RBC: HC50 90 uM.	Nazir S, Khan AI, Maharjan R, Khan SN, Akram MA, Maresca M, Khan FA, Shaheen F. 2024 Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213.|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed	13	
FPDB00207	AP05069	" 
GRMQEFIKKLKAYLRKMKEKFSQIS"	Anti-Gram- S. typhimurium CGMCC 1.1174, activity value is MIC = 2.5 uM||Anti-E. coli CCTCC AB 2018675, activity value is MIC = 5 uM||Anti-S. dysenteriae CGMCC 1.1869, activity value is MIC = 2.5 uM||Anti-P. aeruginosa CGMCC 1.596, activity value is MIC = 5||Anti-K. pneumoniae, activity value is MIC = 10 uM||Anti-A. baumannii, activity value is MIC = 5||Anti-S. aureus CMCC 26003 or MRSA ATCC 43300, activity value is MIC = 5 uM||Anti-and E. faecium, activity value is MIC = 2.5 uM||Anti-Gram+ & Gram-||Anti-MRSA||Synergistic AMPs||Antibiofilm||Anticancer	venom, the wolf spider, Lycosa coelestis|||venom, the wolf spider, Lycosa coelestis, Asia|||venom, the wolf spider, Lycosa coelestis, Asia	Helix	"6.15% hemolysis|||LC-AMP-I1: At a maximum concentration of 320 µM, the hemolysis rate is 10.13%. Melittin: At 5 µM, the hemolysis rate is close to 100%.|||The document explicitly provides the core hemolytic data of the antimicrobial peptide LC-AMP-I1, using rabbit red blood cells as the test subject. The specific hemolysis rates were determined through hemolysis assays, with the key information as follows:

1. Core Hemolytic Data of LC-AMP-I1

- Hemolysis rate: At the highest tested concentration of 320 μM (corresponding to a mass concentration of 987.75 μg/ml), the hemolysis rate of LC-AMP-I1 was only 10.13%, far lower than the hemolytic activity of the positive control melittin (honey bee venom peptide), for which the hemolysis rate is nearly 100% at 5 μM.
- Concentration dependence: In the experiment, the concentration gradient of LC-AMP-I1 was 5–320 μM. Low hemolytic activity was observed only at the highest concentration, while within its effective antimicrobial concentration range (2.5–10 μM, corresponding to MIC values against multidrug-resistant bacteria), the hemolysis rate was even lower, demonstrating excellent safety.

2. Experimental Method Details

1. Red blood cell preparation: Rabbit red blood cells were washed three times with PBS and resuspended to a 1% red blood cell solution.
2. Hemolysis reaction: Red blood cells were mixed with LC-AMP-I1 at various concentrations (5–320 μM) and incubated at 37 °C for 1 hour. The mixture was then centrifuged at 930 × g for 5 minutes, and the absorbance of the supernatant at 570 nm was measured to reflect the amount of hemoglobin released.
3. Control setup: 0.1% Triton X-100 (100% hemolysis) and PBS (0% hemolysis) were used as controls. The hemolysis rate was calculated according to the formula:

  Hemolysis rate (%) = [(A_sample - A_PBS) / (A_Triton X-100 - A_PBS)] × 100%

3. Key Conclusions

LC-AMP-I1 exhibits extremely low hemolytic activity. Even at 320 μM, which far exceeds its effective antimicrobial concentration range (2.5–10 μM), the hemolysis rate is only 10.13%. It shows negligible toxicity to normal mammalian cells (such as LO2 liver cells and HEK293T kidney cells, with high cell viability) and presents some selective toxicity toward tumor cells (such as 4T1 breast cancer cells). This characteristic provides a strong safety foundation for in vivo applications (e.g., no toxic reactions observed in a neutropenic mouse thigh infection model at a dose of 20,000 μg/kg), making LC-AMP-I1 a promising candidate as an alternative to conventional antibiotics."	Wang J, Liu X, Song Y, Liu Z, Tang X, Tan H. 2024 Antimicrob Agents Chemother. 2025 Jan 31;69(1):e0042424. doi: 10.1128/aac.00424-24. PubMed|||2025 Jan 31;69(1):e0042424. doi: 10.1128/aac.00424-24. Epub 2024 Dec 2.|||Antimicrob Agents Chemother. 2025 Jan 31;69(1):e0042424. doi: 10.1128/aac.00424-24. PubMed	25	
FPDB00208	AP05054|||DRAMP29051|||Ctn|||DRAMP29051	" 
KKRLKKIFKKPMVIGVTIPF"	Anti-Gram+ E. faecalis ATCC 29212 and a clinical isolate, activity value is MIC = 54 uM||Anti-S. aureus ATCC 29213 and a clinical isolate, activity value is MIC = 54 uM||Anti-S. pyogenes clinical isolate, activity value is MIC = 3.4 uM||Anti-P. aeruginosa ATCC 27853 and a clinical isolate, activity value is MIC = 27 uM||Anti-K. pneumoniae clinical isolate, activity value is MIC = 3.4 uM||Anti-E. coli ATCC 25922 and a clinical isolate, activity value is MIC = 0.11||Anti-and A. baumannii clinical isolate, activity value is MIC = 1.7 uM||Anti-Gram+ & Gram-||Synergistic AMPs||Anticancer||Anti-Candida albicans ATCC 90028, activity value is MIC = 10 uM||Anti-Candida albicans LAB, activity value is MIC = 0125||Anti-C. albicans ATCC90028, activity value is MIC = 20 ug/ml||Anti-C. albicans LAB, activity value is MIC = 0125||Anti-C. laurentii LAB, activity value is MIC = 0402||Anti-C. laurentii LAB, activity value is MIC = 0403||Anti-C. neoformans LAB, activity value is MIC = 0405||Anti-C. neoformans LAB, activity value is MIC = 0406	sequence truncation, snake cathelicidin analog, animal-derived, natural derivatives|||Crotalus durissus terrificus (South American rattlesnake)	Helix||α-helical	7% and 33% hemolysis at 100 and 400 uM, respectively|||No hemolysis information or data found in the reference(s) presented in this entry	Falcao CB, Pérez-Peinado C, de la Torre BG, Mayol X, Zamora-Carreras H, Jiménez MÁ, Rádis-Baptista G, Andreu D. 2015 J Med Chem. 2015 Nov 12;58(21):8553-63. doi: 10.1021/acs.jmedchem.5b01142. PubMed|||J Med Chem. 2015 Nov 12;58(21):8553-63. doi: 10.1021/acs.jmedchem.5b01142. PubMed|||Int J Mol Sci. 2020 Nov 6;21(21):8339. doi: 10.3390/ijms21218339.||Ref.33172206|||31626724|||Int J Mol Sci. 2020 Nov 6;21(21):8339. doi: 10.3390/ijms21218339.||Ref.33172206	20	
FPDB00209	AP05053|||Ctn|||DRAMP31925	KRFKKFFKKVKKSV	Anti-E. faecalis ATCC 29212 and a clinical isolate, activity value is MIC = 71 uM||Anti-S. aureus ATCC 29213 and a clinical isolate, activity value is MIC = 71 uM||Anti-S. pyogenes clinical isolate, activity value is MIC = 36 uM||Anti-P. aeruginosa ATCC 27853 and a clinical isolate, activity value is MIC = 71 uM||Anti-K. pneumoniae clinical isolate, activity value is MIC = 71 uM||Anti-E. coli ATCC 25922 and a clinical isolate, activity value is MIC = 71 uM||Anti-and A. baumannii clinical isolate, activity value is MIC = 71 uM||Anti-Gram+ & Gram-||Synergistic AMPs||Anticancer||Antifungal||Antimicrobial	sequence truncation, snake cathelicidin analog, animal-derived, natural derivatives|||Crotalus durissus terrificus [South American rattlesnake]|||Rattlesnake Venom Cathelicidin	Helix	7% and 33% hemolysis at 100 and 400 uM, respectively|||Human erythrocytes: nonhemolytic up to 400 uM, and their equimolar mixture at that concentration caused only 7% hemolysis	Falcao CB, Pérez-Peinado C, de la Torre BG, Mayol X, Zamora-Carreras H, Jiménez MÁ, Rádis-Baptista G, Andreu D. 2015 J Med Chem. 2015 Nov 12;58(21):8553-63. doi: 10.1021/acs.jmedchem.5b01142. PubMed|||J Med Chem. 2015 Nov 12;58(21):8553-63. doi: 10.1021/acs.jmedchem.5b01142. PubMed|||31626724|||J Med Chem. 2015 Nov 12;58(21):8553-63.	14	
FPDB00210	AP05050|||DRAMP32279	 GFPCGESCVYIPCFTAAIGCSCKSKVCYKN	exerted dose-dependent nematocidal activity against C. elegans  .||Antimicrobial||Anticancer	Hybanthus enneaspermus|||medicinal herb Hybanthus enneaspermus|||medicinal herb Hybanthus enneaspermus	N/A	hyen D exhibited the highest hemolytic activity, followed by cyO2|||Human red blood cells (hRBCs): HC50=24.56±2.16 uM	Du Q, Chan LY, Gilding EK, Henriques ST, Condon ND, Ravipati AS, Kaas Q, Huang YH, Craik DJ.2020 J Biol Chem. 2020 Aug 7;295(32):10911-10925. doi: 10.1074/jbc.RA120.012627. PubMed||Bajpai et al., 2023|||J Biol Chem. 2020 Aug 7;295(32):10911-10925.	30	
FPDB00211	AP04860	FLPFLGKLFSGIF	Anti-E. coli ATCC 25922, activity value is MIC = 16 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 16 uM||Anti-and S. aureus ATCC 25923, activity value is MIC = 8 uM	skin secretion, the Amazon River frog, Lithobates palmipes (Ranidae), Brazil, South America	N/A	N/A	Barbosa GG, de Santana CJC, Silva TL, Santana BCG, Paiva PMG, de Freitas GG, Brand GD, Júnior ORP, Castro MS, Napoleão TH. 2024 Comp Biochem Physiol B Biochem Mol Biol. 2024 Oct 18:111041. doi: 10.1016/j.cbpb.2024.111041. PubMed|||Comp Biochem Physiol B Biochem Mol Biol. 2024 Oct 18:111041. doi: 10.1016/j.cbpb.2024.111041. PubMed	13	
FPDB00212	AP04839|||DRAMP32284	ALWKDMLKGIGKLAGKAALGAVKTLV	Anti-S. aureus NCTC 10788or MRSA NCTC 12493, activity value is MIC = 2 uM||Anti-E. faecalis NCTC 1269, activity value is MIC = 4 uM||Anti-E. coli NCTC 10418, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 2 uM||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 1 uM||Anti-MCF-7, activity value is IC50 = 2.92 uM||Anti-PC-3, activity value is IC50 = 4.15 uM||Anti-and U251 MG cells, activity value is IC50 = 2.47 uM||Antimicrobial||Anticancer	Phyllomedusa palliata, South America|||Phyllomedusa palliata Skin Secretions|||Phyllomedusa palliata Skin Secretions	Helix	Hemolysis concentration for 50% (HC₅₀): 38.77 uM Hemolysis rate at 16 uM concentration: <20%|||horse RBC: HC50 38.77 uM. Induced a very low degree of LDH release in normal HMEC-1 cells (<10%).|||Horse erythrocytes: Dermaseptin-PP exhibited only a moderate hemolytic effect (<20% at 16 uM with a calculated HC50 of 38.77 uM)|||horse RBC: HC50 38.77 uM.	Dong Z, Hu H, Yu X, Tan L, Ma C, Xi X, Li L, Wang L, Zhou M, Chen T, Du S, Lu Y.2020Front Chem. 2020 Jun 5;8:476. doi: 10.3389/fchem.2020.00476. PubMed|||2020 Jun 5:8:476. doi: 10.3389/fchem.2020.00476. eCollection 2020.|||Front Chem. 2020 Jun 5;8:476. doi: 10.3389/fchem.2020.00476. PubMed|||J Biol Chem. 2020 Aug 7;295(32):10911-10925.|||Front Chem. 2020 Jun 5;8:476.|||Front Chem. 2020 Jun 5;8:476. doi: 10.3389/fchem.2020.00476. PubMed	26	
FPDB00213	AP04836	" 
FFPKVAGVAAKVLKKFCTISKKC"	Anti-S. aureus NCTC 6538, activity value is MIC = 32 uM||Anti-493, activity value is MIC > 128 uM||Anti-697, activity value is MIC = 64 uM||Anti-E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-816, activity value is MIC = 4 uM||Anti-P. aeruginosa ATCC CRM 9027, activity value is MIC = 16 uM||Anti-A. baumannii BAA 747, activity value is MIC = 16 uM||Anti-231, activity value is MIC = 16 uM	amino acid substitution, amino acid deletion, amphibians, animal-derived, natural derivative	Helix	horse RBC: HC50 >128 uM, less hemo.lytic. Less toxic to HaCaT skin cells (IC50 128.1 uM). Also showed effects on both H838 (IC50 4.54 uM) and MCF-7 (IC50 7.19 uM) cancer cell lines.|||horse RBC: HC50 >128 uM, less hemo.lytic.	Wang J, Hu J, Pu W, Chen X, Ma C, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, Wang L. 2024 Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed|||Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed|||Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed	23	
FPDB00214	AP04831	FFPIVAGVAAKVLKKIFCTISKKC	Anti-493, activity value is MIC = 2 uM||Anti-697, activity value is MIC = 4 uM||Anti-E. coli ATCC 8739, activity value is MIC = 4 uM||Anti-816, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC CRM 9027, activity value is MIC = 8 uM||Anti-A. baumannii BAA 747, activity value is MIC = 8 uM||Anti-231, activity value is MIC > 128 uM	skin secretions, the northern leopard frog, Rana pipiens, North America|||skin secretions, the northern leopard frog, Rana pipiens, North America	Helix	HC₁₀ values: Brevinin-1pl: 8.28 uM [Lys⁴] brevinin-1pl: 13.68 uM [Lys⁴, Ala¹³] brevinin-1pl: 4.59 uM [Lys⁴, Ala¹⁶] brevinin-1pl: 2.51 uM [Lys⁴, Ala¹³,¹⁶] brevinin-1pl: 22 uM des-Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM des-Leu¹³,Ala¹⁶-[Lys⁴] HC₃₀ values: Brevinin-1pl: 37.64 uM [Lys⁴] brevinin-1pl: 80.77 uM [Lys⁴, Ala¹³] brevinin-1pl: 41.34 uM [Lys⁴, Ala¹⁶] brevinin-1pl: 84.86 uM [Lys⁴, Ala¹³,¹⁶] brevinin-1pl: >128 uM des-Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM des-Leu¹³,Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM|||horse RBC: HC50 37.64 uM, hemolytic. Less toxic to HaCaT skin cells (IC50 62.71 uM). Also showed effects on both H838 (IC50 6.88 uM) and MCF-7 (IC50 7.6 uM) cancer cell lines.	Wang J, Hu J, Pu W, Chen X, Ma C, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, Wang L. 2024 Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed|||2024 Sep 19:23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. eCollection 2024 Dec.|||Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed	24	
FPDB00215	AP04819	" 
FLSLIPKAIKAVKALAKKL"	Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 2 uM||Anti-E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-A. baumannii BAA 747, activity value is MIC = 2 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 16 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anticancer	amino acid substitution, amphibian peptide analog, animal-derived, natural derivative	Helix	PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||In vitro toxicity: horse RBC: HC50 32 uM. It showed toxicity to both cancer and non-cancer cells.|||w90c6t7w1sexseowqbf1|||horse RBC: HC50 32 uM. It showed toxicity to both cancer and non-cancer cells.	Yin W, Yao J, Leng X, Ma C, Chen X, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, et al. 2024 Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI	19	
FPDB00216	AP04818|||AP04818|||AP04819	" 
FLSLIPKAIKAVSALAKKL"	Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 2 uM||Anti-E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-A. baumannii BAA 747, activity value is MIC = 4 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 16 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-A. baumannii BAA 747, activity value is MIC = 2 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anticancer	amino acid substitution, amphibian peptide analog, animal-derived, natural derivative	Helix	PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||horse RBC: HC50 64 uM. It showed toxicity to both cancer and non-cancer cells.|||w90c6t7w1sexseowqbf1	Yin W, Yao J, Leng X, Ma C, Chen X, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, et al. 2024 Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098.|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI	19	
FPDB00217	AP04815	" 
FLSLIPHAISAVSALAKHL"	Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 2||Anti-E. coli ATCC 8739, activity value is MIC = 16 uM||Anti-A.baumannii BAA 747, activity value is MIC > 128 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 64 uM||Anti-P.aeruginosa ATCC 9027, activity value is MIC > 128 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anticancer	the skin secretion, Super Tiger Leg Monkey Tree Frog, Phyllomedusa tomopterna, Central America, South America|||the skin secretion, Super Tiger Leg Monkey Tree Frog, Phyllomedusa tomopterna, Central America, South America	Helix	PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||horse RBC: HC50 64 uM.|||w90c6t7w1sexseowqbf1	Yin W, Yao J, Leng X, Ma C, Chen X, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, et al. 2024 Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI	19	
FPDB00218	AP04729|||AP04729|||AaeAP1a|||DRAMP21253|||AaeAP1a|||DRAMP21253	" 
FLFKLIPKAIKGLVKAIRK"	Anti-S. aurerus, activity value is MIC = 4 ug/ml||Anti-E.coli, activity value is MIC = 16 ug/ml||Anti-and C. albicans, activity value is MIC = 4 ug/ml||Antibacterial||Antifungal ; Androctonus aeneas||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-E. coli, activity value is MIC = 16 ug/ml||Anti-C. albicans S, activity value is MIC = 4 ug/ml||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||activity value is MBC = 32 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 16 ug/ml||Anti-##Fungi : Candida albicans, activity value is MIC = 4 ug/ml||activity value is MBC = 16 ug/ml	amino acid substitution, scorpions, animal-derived, natural derivative|||amino acid substitution, scorpions, animal-derived, natural derivative|||Androctonus aeneas|||Synthetic construct	N/A	horse RBC: 100% hemolysis at 64 ug/ml.|||S. aureus (MIC= 4 ug/ml), E. coli (MIC= 16 ug/ml), C. albicans S (MIC= 4 ug/ml)||Horse RBCs ( 100% hemolysis at 32 ug/ml)|||Horse RBCs ( 100% hemolysis at 32 ug/ml)|||Horse RBCs ( 100% hemolysis at 32 ug/ml)|||[Ref.25626077] 100% hemolysis at 32 ug/ml against horse red blood cells|||horse RBC: 100% hemolysis at 64 ug/ml.	Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C. 2015 Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed|||https://pubmed.ncbi.nlm.nih.gov/25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.||Ref.25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed	19	
FPDB00219	AP04728|||AP04728|||AaeAP2a|||DRAMP21254|||AaeAP2a|||DRAMP21254	" 
FLFKLIPKVIKGLVKAIRK"	Anti-S. aurerus, activity value is MIC = 4 ug/ml||Anti-E.coli, activity value is MIC = 16 ug/ml||Anti-and C. albicans, activity value is MIC = 4 ug/ml||Antibacterial||Antifungal ; Androctonus aeneas||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-E. coli, activity value is MIC = 16 ug/ml||Anti-C. albicans S, activity value is MIC = 4 ug/ml||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||activity value is MBC = 32 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 16 ug/ml||Anti-##Fungi : Candida albicans, activity value is MIC = 4 ug/ml||activity value is MBC = 16 ug/ml	amino acid substitution, scorpions, animal-derived, natural derivative|||amino acid substitution, scorpions, animal-derived, natural derivative|||Androctonus aeneas|||Synthetic construct	N/A	horse RBC: 100% hemolysis at 32 ug/ml.|||S. aureus (MIC= 4 ug/ml), E. coli (MIC= 16 ug/ml), C. albicans S (MIC= 4 ug/ml)||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||[Ref.25626077] 100% hemolysis at 64 ug/ml against horse red blood cells|||horse RBC: 100% hemolysis at 32 ug/ml.	Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C. 2015 Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed|||https://pubmed.ncbi.nlm.nih.gov/25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.||Ref.25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed	19	
FPDB00220	AP04649|||AP04649|||AP-64	DDKPDKPDDKPDDSGKDPKPDFPKFLSLLGTEIIENAVEFILRSMSRSTGFMEFDDNEGKHSSK	Anti-E. coli DH5alpha or O157:H7, activity value is MIC = 3.6 ug/ml||Anti-V. cholerae, activity value is MIC = 37.4 ug/ml||Anti-and P. aeruginosa, activity value is MIC = 66.24 ug/ml||Anti-Escherichia coli O157:H7, activity value is MIC = 3.6 ug/ml||Anti-Vibrio cholerae, activity value is MIC = 37.4 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 66.24 ug/ml	Homo sapiens|||Homo sapiens|||Homo sapiens [Human]	N/A	N/A	Zhong K, Wang Y, Wang Z, Zhang Z, Zhao S, Li H, Huang J, Guo W, Zheng X, Guo G, Zhou L, Yang H, Tong A. 2021 Biomolecules. 2021 Mar 24;11(4):485. doi: 10.3390/biom11040485. PubMed|||Biomolecules. 2021 Mar 24;11(4):485. doi: 10.3390/biom11040485. PubMed|||https://pubmed.ncbi.nlm.nih.gov/33804835	64	
FPDB00221	AP04623	" 
ALWKTLLKHVGKAAGKAALNAVTDMVNQ"	Anti-S. aureus ATCC 12600 MRSA ATCC BAA-1720, activity value is MIC = 4||Anti-E. faecalis ATCC 29212, activity value is MIC = 32 uM||Anti-E. coli ATCC 11755, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 16 uM||Anti-and C. albicans ATCC 10231, activity value is MIC = 4 uM	skin secretion, Painted-belly leaf frog, Phyllomedusa sauvagii, South America|||skin secretion, Painted-belly leaf frog, Phyllomedusa sauvagii, South America	Helix	Der-PS4 exhibited approximately 50% hemolytic activity at a concentration of about 128 μM. At the minimum inhibitory concentrations (MICs), Der-PS4 showed slight hemolytic activity.|||horse RBC: HC50 ~128 uM. It started to show hemolysis at 16 uM.	Chen D, Zhou X, Chen X, Huang L, Xi X, Ma C, Zhou M, Wang L, Chen T.2019 Molecules. 2019 Aug 16;24(16):2974. doi: 10.3390/molecules24162974. PubMed|||2019 Aug 16;24(16):2974. doi: 10.3390/molecules24162974.|||Molecules. 2019 Aug 16;24(16):2974. doi: 10.3390/molecules24162974. PubMed|||Molecules. 2019 Aug 16;24(16):2974. doi: 10.3390/molecules24162974. PubMed	28	
FPDB00222	AP04526|||Stigmurin|||DRAMP20958|||Stigmurin|||DRAMP20958	" 
FFKLIPKLVKGLISAFK"	Anti-Gram- E. coli ATCC 25922, activity value is MIC = 2.34 uM||Anti-E. cloacae ATCC 13047, activity value is MIC = 9.38 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1.17 uM||Anti-S. aureus ATCC 29213, activity value is MIC = 2.34 uM||Anti-S. epidermidis ATCC 122225, activity value is MIC = 9.38 uM||Anti-E. faecalis ATCC 4028, activity value is MIC = 1.17 uM||Anti-s C. albicans ATCC 90028, activity value is MIC = 4.69 uM||Anti-C. krusei ATCC 6258, activity value is MIC = 9.38 uM||Anti-and C. glabrata ATCC 90030, activity value is MIC = 9.38 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.34 uM||Anti-P. aeuruginosa, activity value is MIC = 1.17 uM||Anti-E. cloacae, activity value is MIC = 9.38 uM||Anti-S. aureus, activity value is MIC = 2.34 uM||Anti-S. epidermidis, activity value is MIC = 9.38 uM||Anti-E. faecalis, activity value is MIC = 1.17 uM||Anti-C. albicans, activity value is MIC = 4.69 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 2.34 uM||Anti-Staphylococcus epidermidis ATCC 122225, activity value is MIC = 9.38 uM||Anti-Enterococcus faecalis ATCC 4028, activity value is MIC = 1.17 uM||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 9.38 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1.17 uM||Anti-s: Candida albicans ATCC 90028, activity value is MIC = 4.69 uM||Anti-Candida krusei ATCC 6258, activity value is MIC = 9.38 uM||Anti-Candida glabrata ATCC 90030, activity value is MIC = 9.38 uM||Anti-HeLa cell line, activity value is IC50 = 13.01 uM||Anti-##Gram-negative bacteria: Escherichia coli ATCC 25922, activity value is MIC = 2.34 uM||Anti-##yeasts: Candida albicans ATCC 90028, activity value is MIC = 4.69 uM||Anti-##HeLa cell line, activity value is IC50 = 13.01 uM	amino acid substitution, amino acid truncation, animal-derived, natural derivative|||Synthetic construct|||amino acid substitution, sequence truncation, animal-derived, natural derivative	Helix||Alpha helix	"approximately 30% hemolysis at 75000000 uM.|||Human RBC (30% hemolysis at 75 uM)|||- Test subjects: Healthy human O⁺ red blood cells, incubated at 37°C for 1 hour, detection wavelength 540 nm; negative control (PBS only) showed 0% hemolysis, positive control (Triton-X) showed 100% hemolysis. 

- Natural peptide Stigmurin: Low hemolytic activity in the concentration range of 1.17–75 µM, with a hemolysis rate of only 3% at the highest concentration (75 µM).

- Analogs StigA6 and StigA16: Hemolysis rate around 30% at the highest concentration (75 µM); however, at lower concentrations that exhibit antibacterial and antiproliferative activity (corresponding to MIC and effective concentrations), hemolysis rate is below 10%, indicating minimal toxicity.

- Key correlation: Increased hemolytic activity of the analogs is associated with the hydrophobic moment increase caused by lysine substitution, but hemolytic activity remains low at lower concentrations, not significantly affecting biosafety.|||Human RBC (30% hemolysis at 75 uM)|||[Ref.29670004] Hemolysis 0% at 1.17 [Ref.29670004] Hemolysis 0% at 1.17 uM, hemolysis 2% at 2.34 uM, hemolysis 10% at 4.69 uM, hemolysis 20% at 9.38 uM, hemolysis 35% at 18.75 uM, hemolysis 37% at 37.5 uM, hemolysis 40% at 75 uM against human red blood cells|||human RBC: low levels (<50%) of hemolysis until 75 uM, while the parent peptide showed no hemolysis under the same condition. Updated: seq corrected 10/2024"	Parente AMS, Daniele-Silva A, Furtado AA, Melo MA, Lacerda AF, Queiroz M, Moreno C, Santos E, Rocha HAO, Barbosa EG, Carvalho E, Silva-Júnior AA, Silva MS, Fernandes-Pedrosa MF.2018 Toxins (Basel). 2018 Apr 18;10(4):161. doi: 10.3390/toxins10040161. PubMed|||29670004|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||29670004|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||Toxins (Basel). 2018 Apr 18;10(4):161. doi: 10.3390/toxins10040161. PubMed	17	
FPDB00223	AP04525|||Stigmurin|||DRAMP20957|||Stigmurin|||DRAMP20957	FFSLIPKLVKGLISAFK	Anti-Gram- E. coli ATCC 25922, activity value is MIC = 4.69 uM||Anti-E. cloacae ATCC 13047, activity value is MIC = 18.75 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 9.38 uM||Anti-S. aureus ATCC 29213, activity value is MIC = 2.34 uM||Anti-S. epidermidis ATCC 122225, activity value is MIC = 1.17 uM||Anti-E. faecalis ATCC 4028, activity value is MIC = 1.17 uM||Anti-s C. albicans ATCC 90028, activity value is MIC = 9.38 uM||Anti-C. krusei ATCC 6258, activity value is MIC = 37.5 uM||Anti-and C. glabrata ATCC 90030, activity value is MIC = 17.75 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 4.69 uM||Anti-P. aeuruginosa, activity value is MIC = 9.38 uM||Anti-E. cloacae, activity value is MIC = 18.75 uM||Anti-S. aureus, activity value is MIC = 2.34 uM||Anti-S. epidermidis, activity value is MIC = 1.17 uM||Anti-E. faecalis, activity value is MIC = 1.17 uM||Anti-C. albicans, activity value is MIC = 9.38 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 2.34 uM||Anti-Staphylococcus epidermidis ATCC 122225, activity value is MIC = 9.38 uM||Anti-Enterococcus faecalis ATCC 4028, activity value is MIC = 1.17 uM||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 18.75 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 9.38 uM||Anti-s: Candida albicans ATCC 90028, activity value is MIC = 9.38 uM||Anti-Candida krusei ATCC 6258, activity value is MIC = 37.5 uM||Anti-Candida glabrata ATCC 90030, activity value is MIC = 18.75 uM||Anti-HeLa cell line, activity value is IC50 = 14.01 uM||Anti-##Gram-negative bacteria: Escherichia coli ATCC 25922, activity value is MIC = 4.69 uM||Anti-##yeasts: Candida albicans ATCC 90028, activity value is MIC = 9.38 uM||Anti-##HeLa cell line, activity value is IC50 = 14.01 uM	amino acid substitution, animal-derived, natural derivative|||Synthetic construct	Helix||Alpha helix	"approximately 30% hemolysis at 75000000 uM.|||Human RBC (40% hemolysis at 75 uM)|||- Test subjects: Healthy human O⁺ red blood cells, incubated at 37°C for 1 hour, detection wavelength 540 nm; negative control (PBS only) showed 0% hemolysis, positive control (Triton-X) showed 100% hemolysis. 

- Natural peptide Stigmurin: Low hemolytic activity in the concentration range of 1.17–75 µM, with a hemolysis rate of only 3% at the highest concentration (75 µM).

- Analogs StigA6 and StigA16: Hemolysis rate around 30% at the highest concentration (75 µM); however, at lower concentrations that exhibit antibacterial and antiproliferative activity (corresponding to MIC and effective concentrations), hemolysis rate is below 10%, indicating minimal toxicity.

- Key correlation: Increased hemolytic activity of the analogs is associated with the hydrophobic moment increase caused by lysine substitution, but hemolytic activity remains low at lower concentrations, not significantly affecting biosafety.|||Human RBC (40% hemolysis at 75 uM)|||[Ref.29670004] Hemolysis 0% at 1.17 uM, hemolysis 2% at 2.34 uM, hemolysis 15% at 4.69 uM, hemolysis 27% at 9.38 uM, hemolysis 30% at 18.75 uM, hemolysis 30% at 37.5 uM, hemolysis 27% at 75 uM against human red blood cells|||human RBC: low levels (<50%) of hemolysis until 75 uM, while the parent peptide showed no hemolysis under the same condition."	Parente AMS, Daniele-Silva A, Furtado AA, Melo MA, Lacerda AF, Queiroz M, Moreno C, Santos E, Rocha HAO, Barbosa EG, Carvalho E, Silva-Júnior AA, Silva MS, Fernandes-Pedrosa MF.2018 Toxins (Basel). 2018 Apr 18;10(4):161. doi: 10.3390/toxins10040161. PubMed|||29670004|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||29670004|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||Toxins (Basel). 2018 Apr 18;10(4):161. doi: 10.3390/toxins10040161. PubMed	17	
FPDB00224	AP04231	 FLPLLAGLAASFLPTIFCKISRKC	Anti-Gram+ E. faecalis ATCC 29212, activity value is MIC = 3.125 ug/ml||Anti-S. aureus ATCC 25923 or MDR ATCC 29213, activity value is MIC = 6.25 ug/ml||Anti-S. saprophytics ATCCBAA750, activity value is MIC = 6.25 ug/ml||Anti-S. epidermidis CI 1607BL1D39, activity value is MIC = 12.5 uM||Anti-S. haemolyticus CI 1607BLD590, activity value is MIC = 12.5 ug/ml||Anti-E. coli ATCC 25922, activity value is MIC = 100 ug/ml||Anti-E. hormaechei ATCC700323, activity value is MIC = 100 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 100 ug/ml||Anti-K.pneumoniae ATCC700603, activity value is MIC > 100 ug/ml||Anti-C. koseri CI 1611SED223, activity value is MIC = 50 ug/ml||Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis||Hemolytic||Antibiofilm||Anticancer	skin, Pelophylax nigromaculatus, East Asia|||skin, Pelophylax nigromaculatus, East Asia	N/A	"HC50(50% hemolytic concentration)value of 35.8 ug/ml|||At a concentration of 3.125 µg/ml, the hemolytic activity on sheep red blood cells is not significant;  
When the concentration is >12.5 µg/ml, notable hemolysis occurs;  
50% hemolysis concentration|||The document provides core hemolytic data for the novel antimicrobial peptide Brevinin-1BW, with the following specific results: 
 
1. Key hemolytic indicators
 
Characteristics of concentration-dependent hemolysis: 
At a concentration of 3.125 ug/ml, Brevinin-1BW's hemolytic activity on sheep red blood cells (2% suspension) was not obvious, with almost no hemolytic effect. 
When the concentration exceeds 12.5 μg/ml, significant hemolysis begins, and the hemolysis rate increases with higher concentration. 
Its 50% hemolytic concentration (HC₅₀) is 35.8 ug/ml, meaning that at this concentration, 50% of sheep erythrocytes can be lysed (Figure 5B). 
Security Comparison: 
The effective antibacterial concentration (MIC) of Brevinin-1BW is much lower than its hemolytic activity-related concentration: against Gram-positive bacteria (such as Enterococcus faecalisis ATCC 29212 and Staphylococcus aureus ATCC 25923), the MIC is 3.125~6.25 ug/ml, both below 12.5 ug/ml (significant hemolysis onset concentration), indicating a low risk of hemolysis at effective antibacterial doses. 
 
2. Additional Explanation
 
Experimental conditions: Using 2% sheep red blood cell suspension, incubate Brevinin-1BW (3.125~100 ug/ml) at different concentrations with red blood cell suspension at 37°C for 2 hours; Using normal saline as the negative control (no hemolysis), 0.1% Triton X-100 as the positive control (complete hemolysis), after centrifugation, measure the absorbance of the supernatant at 570 nm. Calculate the hemolysis rate according to the formula: hemolysis rate % = (absorbance of negative control - absorbance of sample) / (absorbance of negative control - absorbance of positive control) × 100%. 
Hemolytic characteristics and associations: 
The hemolytic activity of Brevinin-1BW is related to its structure. As a member of the Brevinin-1 family, its C-terminus contains a ""Rana box"" disulfide bond structure and has high hydrophobicity (hydrophobicity index 0.838, Table 1). Excessive hydrophobicity may cause it to damage mammalian cell membranes at high concentrations, triggering hemolysis. 
Combined with cytotoxicity data (CC₅₀ for normal cells such as HaCaT and HUVEC both > 28 ug/ml, Table 4), it is further demonstrated that it has good biosafety within the range of potential clinical application concentrations (below 12.5 ug/ml)."	Chen Z, Wang L, He D, Liu Q, Han Q, Zhang J, Zhang AM, Song Y. 2024 Molecules. 2024 Mar 29;29(7):1534. doi: 10.3390/molecules29071534. PubMed|||. 2024 Mar 29;29(7):1534. doi: 10.3390/molecules29071534.|||Molecules. 2024 Mar 29;29(7):1534. doi: 10.3390/molecules29071534. PubMed|||Molecules. 2024 Mar 29;29(7):1534. doi: 10.3390/molecules29071534. PubMed	24	
FPDB00225	AP04191	FLGLIPALAGAIGNLIK	Anti-weakly active against E. coli DSM 787, activity value is MIC = 100 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 100 ug/ml||Anti-S-epidermidis DSM 28319, activity value is MIC > 100 ug/ml||Anti-P-aeruginosa DSM 50071, activity value is MIC > 100 ug/ml||Anti-K-pneumoniae ATCC BAA 1705, activity value is MIC > 100 ug/ml||Anti-A. baumannii DSM 30008, activity value is MIC = 100 ug/ml||Anti-E. faecalis MF 06036, activity value is MIC = 100 ug/ml||Anti-E. faecium NCTC 12201, activity value is MIC = 50 ug/ml||Anti-C. difficile R20291 or 630 BAA1382, activity value is MIC = 25||Anti-Gram+ & Gram-||Anti-MRSA||anti-diabetes||Anticancer	skin secretions, the banana tree dwelling frog, Boana platanera (Hylidae; Hylinae), Trinidad, South America|||skin secretions, the banana tree dwelling frog, Boana platanera (Hylidae; Hylinae), Trinidad, South America	N/A	concentration of peptide producing 50% hemolysis	Conlon JM, Sridhar A, Khan D, Cunning TS, Delaney JJ, Taggart MG, Ternan NG, Leprince J, Coquet L, Jouenne T, Attoub S, Mechkarska M. 2024 Biochimie. 2024 Mar 30:S0300-9084(24)00070-1. doi: 10.1016/j.biochi.2024.03.012. PubMed|||2024 Aug:223:23-30. doi: 10.1016/j.biochi.2024.03.012. Epub 2024 Mar 30.|||Biochimie. 2024 Mar 30:S0300-9084(24)00070-1. doi: 10.1016/j.biochi.2024.03.012. PubMed	17	
FPDB00226	AP04190	FLGTVLKLGKAIAKTVVPMLTNAMQPKQ	Anti-E. coli DSM 787, activity value is MIC = 6.25 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 6.25 ug/ml||Anti-S. epidermidis DSM 28319, activity value is MIC = 12.5 ug/ml||Anti-P. aeruginosa DSM 50071, activity value is MIC = 100 ug/ml||Anti-K. pneumoniae ATCC BAA 1705, activity value is MIC = 25 ug/ml||Anti-A. baumannii DSM 30008, activity value is MIC = 6.25 ug/ml||Anti-E. faecalis MF 06036, activity value is MIC = 50 ug/ml||Anti-E. faecium NCTC 12201, activity value is MIC = 6.25 ug/ml||Anti-C. difficile R20291 or 630 BAA1382, activity value is MIC = 6.25 ug/ml||Anti-Gram+ & Gram-||Anti-MRSA||Anticancer	skin secretions, the banana tree dwelling frog, Boana platanera (Hylidae; Hylinae), Trinidad, South America|||skin secretions, the banana tree dwelling frog, Boana platanera (Hylidae; Hylinae), Trinidad, South America	Helix	concentration of peptide producing 50% hemolysis	Conlon JM, Sridhar A, Khan D, Cunning TS, Delaney JJ, Taggart MG, Ternan NG, Leprince J, Coquet L, Jouenne T, Attoub S, Mechkarska M. 2024 Biochimie. 2024 Mar 30:S0300-9084(24)00070-1. doi: 10.1016/j.biochi.2024.03.012. PubMed|||2024 Aug:223:23-30. doi: 10.1016/j.biochi.2024.03.012. Epub 2024 Mar 30.|||Biochimie. 2024 Mar 30:S0300-9084(24)00070-1. doi: 10.1016/j.biochi.2024.03.012. PubMed	28	
FPDB00227	AP04189	GVFDTVKKIGKAVGKFALGVAKNYLNS	Anti-E. coli DSM 787, activity value is MIC = 3.13 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 25 ug/ml||Anti-S. epidermidis DSM 28319, activity value is MIC = 6.25 ug/ml||Anti-P. aeruginosa DSM 50071, activity value is MIC = 50 ug/ml||Anti-K. pneumoniae ATCC BAA 1705, activity value is MIC = 3.13 ug/ml||Anti-A. baumannii DSM 30008, activity value is MIC = 3.13 ug/ml||Anti-E. faecalis MF 06036, activity value is MIC = 25 ug/ml||Anti-E. faecium NCTC 12201, activity value is MIC = 3.13 ug/ml||Anti-C. difficile R20291 or 630 BAA1382, activity value is MIC = 3.13 ug/ml||Anti-Gram+ & Gram-||Anti-MRSA||anti-diabetes||Anticancer	skin secretions, the banana tree dwelling frog, Boana platanera (Hylidae; Hylinae), Trinidad, South America|||skin secretions, the banana tree dwelling frog, Boana platanera (Hylidae; Hylinae), Trinidad, South America	N/A	concentration of peptide producing 50% hemolysis	Conlon JM, Sridhar A, Khan D, Cunning TS, Delaney JJ, Taggart MG, Ternan NG, Leprince J, Coquet L, Jouenne T, Attoub S, Mechkarska M. 2024 Biochimie. 2024 Mar 30:S0300-9084(24)00070-1. doi: 10.1016/j.biochi.2024.03.012. PubMed|||2024 Aug:223:23-30. doi: 10.1016/j.biochi.2024.03.012. Epub 2024 Mar 30.|||Biochimie. 2024 Mar 30:S0300-9084(24)00070-1. doi: 10.1016/j.biochi.2024.03.012. PubMed	27	
FPDB00228	AP04053	GFMKTWKNVWKNVAATLLKLLK	Anti-S. aureus NCTC 10788 or MRSA, activity value is MIC = 4 uM||Anti-E. coli ATCC 8739, activity value is MIC = 8 uM||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 16 uM||Anti-E. faecium NTCC 12697, activity value is MIC = 8 uM||Anti-and P. aeruginosa ATCC 9027, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Anti-MRSA||Antibiofilm||Anticancer	sequence truncation, Amino acid substitution, animal-derived, natural derivative	Helix	"R2AW: approximately 20% hemolytic activity, highest tested concentration 256 µM [Ser²³,²⁹] R2AW: approximately 10% hemolytic activity. R2AW(1-22): no hemolytic activity observed. R2AW(1-22)-NH₂: approximately 10% hemolytic activity [Lys⁴,¹⁹,Leu²⁰] R2AW(1-22)-NH₂: no hemolytic activity observed, highest tested concentration 16 µM [Trp⁶,¹⁰] R2AW(1-22)-NH₂: approximately 20% hemolytic activity, highest tested concentration 2 µM.|||horse RBC: low hemolytic (HC50 8 uM).|||The hemolytic data of R2AW and its derivatives against horse red blood cells provided in the document are presented as hemolysis rates (%) at different concentrations, with the specific results as follows:

1. Hemolytic characteristics of each peptide (based on 2% horse red blood cell suspension, incubated at 37 °C for 2 hours)

Peptide Name | Key Hemolytic Properties (Concentration Range: 1~256 µM)
--- | ---
Parent Peptide R2AW | At the highest concentration of 256 µM, the hemolysis rate is about 20%
[Ser²³,²⁹]R2AW | At the highest concentration of 256 µM, the hemolysis rate is about 10%, lower than the parent peptide
R2AW(1-22) | No hemolysis observed across the entire concentration range (1~256 µM) (due to removal of the Rana box and lack of amidation)
R2AW(1-22)-NH₂ | At the highest concentration of 256 µM, the hemolysis rate is about 10%, similar to [Ser²³,²⁹]R2AW
[Lys⁴,¹⁹, Leu²⁰]R2AW(1-22)-NH₂ | No hemolysis observed at its maximum minimum bactericidal concentration (MBC=16 µM), optimal safety
[Trp⁶,¹⁰]R2AW(1-22)-NH₂ | Hemolysis of about 20% occurs even at a low concentration (2 µM), and hemolysis increases further at high concentrations, exhibiting the highest toxicity

2. Additional Notes

Control settings: the 0.1% Triton X-100 treatment group served as the 100% hemolysis positive control, and the PBS treatment group as the 0% hemolysis negative control. Hemolysis rate was calculated using the formula:
Hemolysis Rate = (Absorbance of experimental group - Absorbance of negative control) / (Absorbance of positive control - Absorbance of negative control) × 100%.

Key conclusions:
- Removal of the Rana box (R2AW(1-22)) or substituting cysteine with serine ([Ser²³,²⁹]R2AW) can reduce hemolysis.
- The derivative with increased cationicity and hydrophobicity, [Lys⁴,¹⁹, Leu²⁰]R2AW(1-22)-NH₂, shows no hemolysis at effective antibacterial concentrations, combining high activity with low toxicity.
- Tryptophan substitution ([Trp⁶,¹⁰]R2AW(1-22)-NH₂) enhances anticancer activity but significantly increases hemolysis due to excessive hydrophobicity, limiting clinical application."	Yao A, Liu T, Cai Y, Zhou S, Chen X, Zhou M, Ma C, Chen T, Shaw C, Wang L2023 Antibiotics (Basel). 2023 Dec 19;13(1):5. doi: 10.3390/antibiotics13010005. PubMed|||2023 Dec 19;13(1):5. doi: 10.3390/antibiotics13010005.|||Antibiotics (Basel). 2023 Dec 19;13(1):5. doi: 10.3390/antibiotics13010005. PubMed	22	
FPDB00229	AP04052	GFMKTAKNVAKNVAATLLKLLK	Anti-S. aureus NCTC 10788 or MRSA, activity value is MIC = 2 uM||Anti-E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 4 uM||Anti-E. faecium NTCC 12697, activity value is MIC = 4 uM||Anti-and P. aeruginosa ATCC 9027, activity value is MIC = 8 uM||Anti-Gram+ & Gram-||Anti-MRSA||Antibiofilm||Anticancer	sequence truncation, Amino acid substitution, animal-derived, natural derivative	Helix	"R2AW: approximately 20% hemolytic activity, highest tested concentration 256 µM [Ser²³,²⁹] R2AW: approximately 10% hemolytic activity. R2AW(1-22): no hemolytic activity observed. R2AW(1-22)-NH₂: approximately 10% hemolytic activity [Lys⁴,¹⁹,Leu²⁰] R2AW(1-22)-NH₂: no hemolytic activity observed, highest tested concentration 16 µM [Trp⁶,¹⁰] R2AW(1-22)-NH₂: approximately 20% hemolytic activity, highest tested concentration 2 µM.|||horse RBC: low hemo.lytic (HC50> 128 uM).|||The hemolytic data of R2AW and its derivatives against horse red blood cells provided in the document are presented as hemolysis rates (%) at different concentrations, with the specific results as follows:

1. Hemolytic characteristics of each peptide (based on 2% horse red blood cell suspension, incubated at 37 °C for 2 hours)

Peptide Name | Key Hemolytic Properties (Concentration Range: 1~256 µM)
--- | ---
Parent Peptide R2AW | At the highest concentration of 256 µM, the hemolysis rate is about 20%
[Ser²³,²⁹]R2AW | At the highest concentration of 256 µM, the hemolysis rate is about 10%, lower than the parent peptide
R2AW(1-22) | No hemolysis observed across the entire concentration range (1~256 µM) (due to removal of the Rana box and lack of amidation)
R2AW(1-22)-NH₂ | At the highest concentration of 256 µM, the hemolysis rate is about 10%, similar to [Ser²³,²⁹]R2AW
[Lys⁴,¹⁹, Leu²⁰]R2AW(1-22)-NH₂ | No hemolysis observed at its maximum minimum bactericidal concentration (MBC=16 µM), optimal safety
[Trp⁶,¹⁰]R2AW(1-22)-NH₂ | Hemolysis of about 20% occurs even at a low concentration (2 µM), and hemolysis increases further at high concentrations, exhibiting the highest toxicity

2. Additional Notes

Control settings: the 0.1% Triton X-100 treatment group served as the 100% hemolysis positive control, and the PBS treatment group as the 0% hemolysis negative control. Hemolysis rate was calculated using the formula:
Hemolysis Rate = (Absorbance of experimental group - Absorbance of negative control) / (Absorbance of positive control - Absorbance of negative control) × 100%.

Key conclusions:
- Removal of the Rana box (R2AW(1-22)) or substituting cysteine with serine ([Ser²³,²⁹]R2AW) can reduce hemolysis.
- The derivative with increased cationicity and hydrophobicity, [Lys⁴,¹⁹, Leu²⁰]R2AW(1-22)-NH₂, shows no hemolysis at effective antibacterial concentrations, combining high activity with low toxicity.
- Tryptophan substitution ([Trp⁶,¹⁰]R2AW(1-22)-NH₂) enhances anticancer activity but significantly increases hemolysis due to excessive hydrophobicity, limiting clinical application."	Yao A, Liu T, Cai Y, Zhou S, Chen X, Zhou M, Ma C, Chen T, Shaw C, Wang L2023 Antibiotics (Basel). 2023 Dec 19;13(1):5. doi: 10.3390/antibiotics13010005. PubMed|||2023 Dec 19;13(1):5. doi: 10.3390/antibiotics13010005.|||Antibiotics (Basel). 2023 Dec 19;13(1):5. doi: 10.3390/antibiotics13010005. PubMed	22	
FPDB00230	AP04035|||AP04035|||CAMPSQ23276|||DRAMP29124	LNLKKLLKVAKKIL	Anti-Gram+ S. aureus ATCC 25923, activity value is MIC = 32 uM||Anti-B. cereus ATCC 11778, activity value is MIC = 16 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 4 uM||Anti-L. monocytogenes ATCC 15313, activity value is MIC = 4 uM||Anti-E. coli ATCC 25922, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 64 uM||Anti-S. enterica ATCC 13076, activity value is MIC = 32 uM||Anti-and fungi C. albicans ATCC 10231, activity value is MIC = 16 uM||LNLKKLLKVAKKIL||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 16 uM||Anti-Bacillus subtilis ATCC 23857, activity value is MIC = 4 uM||Anti-##Gram-negative bacteria:Escherichia coli ATCC 25922, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 4 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 8 uM||Anti-H1975, activity value is IC50 = 6.25012||Anti-and H441, activity value is IC50 = 3.1	Amino acid substitution|||Amino acid substitution|||Synthetic construct|||Synthetic construct	Alpha helix,random coil	human RBC, HC50 128 uM, less hemo.lytic.|||Mouse erythrocytes (15% Hemolysis at 256 uM|||human RBC, HC50 128 uM, less hemo.lytic.|||[Ref.33285267]15% hemolysis against mouse erythrocytes at 256 uM.	Thi Phuong HB, Huy BL, Van KN, Thi ND, Thi TB, Thi Hai YN, Thanh TB, Xuan HL, Thi Thanh BN. 2023 ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed|||ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed|||33285267|||ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed|||Eur J Pharm Sci. 2021 Mar 1;158:105665.||Ref.33285267|||ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed	14	
FPDB00231	AP03721	ALWKSILKNAGKAALNEINQIV	Anti-S. aureus ATCC CRM 6538, activity value is MIC = 8 uM||Anti-MRSA NCTC 12493, activity value is MIC > 128 uM||Anti-E.faecalis NCTC 12697, activity value is MIC > 128 uM||Anti-or NCTC 13846, activity value is MIC = 2||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 16 uM||Anti-P. aeruginosa ATCC CRM 9027, activity value is MIC = 32 uM||Anti-A. baumannii ATCC BAA 747, activity value is MIC = 16 uM||Anti-and C.albicans ATCC CRM 10231, activity value is MIC > 128 uM||Anti-active against S. aureus ATCC CRM 6538, activity value is MIC = 8 uM	Skin Secretion, Brown-belly leaf frog, Phyllomedusa Tarsius , South America	Helix	N/A	Ma X, Chen Y, Shu A, Jiang Y, Chen X, Ma C, Zhou M, Wang T, Chen T, Shaw C, Wang L. 2023 Molecules. 2023 Sep 11;28(18):6558. doi: 10.3390/molecules28186558. Pub-Med.|||2023 Sep 11;28(18):6558. doi: 10.3390/molecules28186558.	22	
FPDB00232	AP03704	GLMDMLKKVGKVALTVAKSALLP	Anti-Gram+ S. aureus ATCC 12600, activity value is MIC = 31.3 uM||Anti-E. coli ATCC 35218, activity value is MIC = 7.8 uM||Anti-K. pneumoniae ATCC 49472, activity value is MIC = 15.6 uM||Anti-and P. aeruginosa ATCC 9072, activity value is MIC = 15.6 uM	norepinephrine-stimulated skin secretion, the Giant Gladiator Treefrog, the Rusty Treefrog, Boana boans, Trinidad, South America|||norepinephrine-stimulated skin secretion, the Giant Gladiator Treefrog, the Rusty Treefrog, Boana boans, Trinidad, South America	Helix	N/A	Conlon JM, Guilhaudis L, Attoub S, Coquet L, Leprince J, Jouenne T, Mechkarska M. 2023 Antibiotics (Basel). 2023 Jun 25;12(7):1102. doi: 10.3390/antibiotics12071102. Pub-Med.|||Antibiotics (Basel). 2023 Jun 25;12(7):1102. doi: 10.3390/antibiotics12071102. Pub-Med.	23	
FPDB00233	AP03703	GIFKDTLKKVVAAVLTTVADNIHPK	Anti-Gram+ S. aureus ATCC 12600, activity value is MIC = 62.5 uM||Anti-E. coli ATCC 35218, activity value is MIC = 7.8 uM||Anti-K. pneumoniae ATCC 49472, activity value is MIC = 15.6 uM||Anti-and P. aeruginosa ATCC 9072, activity value is MIC = 15.6 uM||Anti-breast adenocarcinoma MDA-MB-231 cells, activity value is IC50 = 64.2 uM||Anti-and colorectal adenocarcinoma HT-29 cells, activity value is IC50 = 84.9 uM	norepinephrine-stimulated skin secretion, the Giant Gladiator Treefrog, the Rusty Treefrog, Boana boans, Trinidad, South America|||norepinephrine-stimulated skin secretion, the Giant Gladiator Treefrog, the Rusty Treefrog, Boana boans, Trinidad, South America	Helix	N/A	Conlon JM, Guilhaudis L, Attoub S, Coquet L, Leprince J, Jouenne T, Mechkarska M. 2023 Antibiotics (Basel). 2023 Jun 25;12(7):1102. doi: 10.3390/antibiotics12071102. Pub-Med.|||Antibiotics (Basel). 2023 Jun 25;12(7):1102. doi: 10.3390/antibiotics12071102. Pub-Med.	25	
FPDB00234	AP03702	FLGVALKLGKVLGKALLPLASSLLHSQ	Anti-Gram+ S. aureus ATCC 12600, activity value is MIC = 7.8 uM||Anti-E. faecium ATCC 19439, activity value is MIC = 31.3 uM||Anti-E.faecalis ATCC 51299, activity value is MIC = 125 uM||Anti-E. coli ATCC 35218, activity value is MIC = 15.6 uM||Anti-K. pneumoniae ATCC 49472, activity value is MIC = 31.3 uM||Anti-and P. aeruginosa ATCC 9072, activity value is MIC = 31.3 uM	norepinephrine-stimulated skin secretion, the Giant Gladiator Treefrog, the Rusty Treefrog, Boana boans, Trinidad, South America|||norepinephrine-stimulated skin secretion, the Giant Gladiator Treefrog, the Rusty Treefrog, Boana boans, Trinidad, South America	Helix	N/A	Conlon JM, Guilhaudis L, Attoub S, Coquet L, Leprince J, Jouenne T, Mechkarska M. 2023 Antibiotics (Basel). 2023 Jun 25;12(7):1102. doi: 10.3390/antibiotics12071102. Pub-Med.|||Antibiotics (Basel). 2023 Jun 25;12(7):1102. doi: 10.3390/antibiotics12071102. Pub-Med.	27	
FPDB00235	AP03680|||DRAMP35969	FLPLLAGLAANFLPKIICKIARKC	Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 8 uM||Anti-E. faecalis NCTC 12697, activity value is MIC = 16 uM||Anti-E. coli ATCC 8739, activity value is MIC = 8 uM||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 16 uM||Anti-C.albicans ATCC 10231, activity value is MIC = 256 uM||Anti-Gram+ & Gram-||Anti-MRSA||Hemolytic||Antibiofilm||Anticancer||Antimicrobial	amino acid substitution, animal-derived, natural derivative|||Synthetic (derived from B1AW)	Helix	"amino acid substitution, animal-derived, natural derivative|||the peptide is toxic: hemolytic HC50 10.6 uM: highly hemolytic. Also HACaT cells (IC50 20.53 uM) and HMEC (IC50 26.45 uM).|||According to the provided document content, the text clearly mentions hemolytic data for two peptides (B1AW and B1AW-K), as follows:

1. Test Conditions

Experimental subjects: defibrinated horse erythrocytes.
Control setup: PBS treatment as 0% hemolysis negative control, 1% Triton X-100 treatment as 100% hemolysis positive control.
Detection method: Peptide solutions (concentrations 1~100 μM) were incubated with 4% red blood cell suspension at 37°C for 2 hours, and absorbance was measured at 570 nm. Hemolysis rate was calculated using the formula:
Haemolysis (%) = \frac{A(sample) - A(negative control)}{A(positive control) - A(negative control)} × 100%

2. Hemolytic Results

(1) Hemolysis rate (Haemolysis %)

Low concentration (5 μM): Both B1AW and B1AW-K showed significant hemolysis, with rates exceeding 20%.
Concentration dependence: As peptide concentration increased (10~100 μM), hemolysis rates of both peptides further increased, with B1AW-K consistently showing stronger hemolytic effects than B1AW (Figure 5).

(2) Half-maximal hemolytic concentration (HC₅₀)

B1AW: HC₅₀ was 23.96 μM (the peptide concentration causing 50% red blood cell hemolysis).
B1AW-K: HC₅₀ was 10.6 μM, only about 44% of B1AW, indicating that the introduction of lysine residues significantly enhanced hemolysis (Table 6).

3. Key Conclusions

Although B1AW-K enhanced antibacterial and anticancer activities through lysine modification, hemolysis was also simultaneously increased. Its HC₅₀ (10.6 μM) was much lower than that of B1AW (23.96 μM), suggesting that further optimization is required to balance activity and toxicity."	Qin H, Zuo W, Ge L, Siu SWI, Wang L, Chen X, Ma C, Chen T, Zhou M, Cao Z, Kwok HF.2023 Comput Struct Biotechnol J. 2023 May 6;21:2960-2972. doi: 10.1016/j.csbj.2023.05.006. Pub-Med.|||Comput Struct Biotechnol J. 2023 May 6;21:2960-2972. doi: 10.1016/j.csbj.2023.05.006. Pub-Med.|||Comput Struct Biotechnol J. 2023 May 6;21:2960-2972. doi: 10.1016/j.csbj.2023.05.006. Pub-Med.|||Comput Struct Biotechnol J. 2023 May 6;21:2960-2972. doi: 10.1016/j.csbj.2023.05.006. Pub-Med.|||Comput Struct Biotechnol J. 2023 May 6;21:2960-2973.	24	
FPDB00236	AP03679|||DRAMP35968	FLPLLAGLAANFLPQIICKIARKC	Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 32 uM||Anti-E. faecalis NCTC 12697, activity value is MIC = 32 uM||Anti-E.coli ATCC 8739, activity value is MIC > 512 uM||Anti-K.pneumoniae ATCC 43816, activity value is MIC > 512 uM||Anti-P.aeruginosa ATCC 9027, activity value is MIC > 512 uM||Anti-C.albicans ATCC 10231, activity value is MIC > 512 uM||Anti-Gram+||Anti-MRSA||Hemolytic||Antibiofilm||Anticancer||Antimicrobial	skin secretion, the Wuyi torrent frog, Amolops wuyiensis, China, Asia|||skin secretion, the Wuyi torrent frog, Amolops wuyiensis, China, Asia|||Skin secretions of the Wuyi torrent frog, Amolops wuyiensis (A. wuyiensisi)	Helix	"skin secretion, the Wuyi torrent frog, Amolops wuyiensis, China, Asia|||the peptide is toxic: hemolytic HC50 23.96 uM: highly hemolytic. Also HACaT cells (IC50 44.09 uM) and HMEC (IC50 32.96 uM).|||According to the provided document content, the text clearly mentions hemolytic data for two peptides (B1AW and B1AW-K), as follows:

1. Test Conditions

Experimental subjects: defibrinated horse erythrocytes.
Control setup: PBS treatment as 0% hemolysis negative control, 1% Triton X-100 treatment as 100% hemolysis positive control.
Detection method: Peptide solutions (concentrations 1~100 μM) were incubated with 4% red blood cell suspension at 37°C for 2 hours, and absorbance was measured at 570 nm. Hemolysis rate was calculated using the formula:
Haemolysis (%) = \frac{A(sample) - A(negative control)}{A(positive control) - A(negative control)} × 100%

2. Hemolytic Results

(1) Hemolysis rate (Haemolysis %)

Low concentration (5 μM): Both B1AW and B1AW-K showed significant hemolysis, with rates exceeding 20%.
Concentration dependence: As peptide concentration increased (10~100 μM), hemolysis rates of both peptides further increased, with B1AW-K consistently showing stronger hemolytic effects than B1AW (Figure 5).

(2) Half-maximal hemolytic concentration (HC₅₀)

B1AW: HC₅₀ was 23.96 μM (the peptide concentration causing 50% red blood cell hemolysis).
B1AW-K: HC₅₀ was 10.6 μM, only about 44% of B1AW, indicating that the introduction of lysine residues significantly enhanced hemolysis (Table 6).

3. Key Conclusions

Although B1AW-K enhanced antibacterial and anticancer activities through lysine modification, hemolysis was also simultaneously increased. Its HC₅₀ (10.6 μM) was much lower than that of B1AW (23.96 μM), suggesting that further optimization is required to balance activity and toxicity."	Qin H, Zuo W, Ge L, Siu SWI, Wang L, Chen X, Ma C, Chen T, Zhou M, Cao Z, Kwok HF.2023 Comput Struct Biotechnol J. 2023 May 6;21:2960-2972. doi: 10.1016/j.csbj.2023.05.006. Pub-Med.|||Comput Struct Biotechnol J. 2023 May 6;21:2960-2972. doi: 10.1016/j.csbj.2023.05.006. Pub-Med.|||Comput Struct Biotechnol J. 2023 May 6;21:2960-2972. doi: 10.1016/j.csbj.2023.05.006. Pub-Med.|||Comput Struct Biotechnol J. 2023 May 6;21:2960-2972. doi: 10.1016/j.csbj.2023.05.006. Pub-Med.|||Comput Struct Biotechnol J. 2023 May 6;21:2960-2972.	24	
FPDB00237	AP03631|||AP03631|||K2-CRAMP18|||DRAMP33028	GKKLKKIGQKIKNFFQKL	Anti-CRAMP-18 E2K is active against E. coli KCTC 1682, activity value is MIC = 3.12 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 1.56 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 0.78 uM||Anti-B. subtilis KCTC 1918, activity value is MIC = 3.12 uM||Anti-S. pyogenes KCTC 3096, activity value is MIC = 3.12 uM||Anti-S. aureus KCTC 1621, activity value is MIC = 1.56 uM||Anti-C. albicans, activity value is MIC = 6.25 uM||Anti-A. fumigatus, activity value is MIC = 12.5 uM||Anti-tumor cells: A549, activity value is IC50 = 25 uM||Anti-K562, activity value is IC50 = 34 uM||Anti-Jurkat, activity value is IC50 = 20 uM||Antimicrobial||Anticancer	amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic (Derived from CRAMP-18)	Helix	2.2% hemolysis at a concentration of 100000 uM|||amino acid substitution, cathelicidin analog, animal-derived, natural derivative||No hemolytic activity.|||0% hemolysis at 100 uM (not hemo.lytic).|||No hemolytic activity.|||0% hemolysis at 100 uM (not hemo.lytic).|||0% hemolysis at 100 uM (not hemo.lytic).	Shin SY, Kang SW, Lee DG, Eom SH, Song WK, Kim JI. 2000 Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.	18	
FPDB00238	AP03630|||AP03630|||MCRAMP	GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ	Anti-E. coli, activity value is MIC = 3.12 uM||Anti-S. typhimurium, activity value is MIC = 3.12 uM||Anti-P. aeruginosa, activity value is MIC = 3.12 uM||Anti-B. subtilis, activity value is MIC = 6.25 uM||Anti-S. pyogenes, activity value is MIC = 6.25 uM||Anti-S. aureus, activity value is MIC = 3.12 uM||Anti-C. albicans, activity value is MIC = 12||Anti-A. fumigatus, activity value is MIC = 12.5 uM||Anti-tumor cells: A549, activity value is IC50 = 22 uM||Anti-K562, activity value is IC50 = 28 uM||Anti-Jurkat, activity value is IC50 = 16 uM||Antibacterial||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibiofilm||Anticancer	bone marrow, saliva, Mice, Mus musculus|||bone marrow, saliva, Mice, Mus musculus|||Mus musculus [Mouse]|||bone marrow, saliva, Mice, Mus musculus	N/A	bone marrow, saliva, Mice, Mus musculus|||2.2% hemolysis at 100 uM (hemo.lytic) (Data from ref for AP3628. This peptide differs from the natural form only by the last Q, which is neutral presumably with a minimal effect on activity).|||2.2% hemolysis at 100 uM (hemo.lytic) (Data from ref for AP3628. This peptide differs from the natural form only by the last Q, which is neutral presumably with a minimal effect on activity).|||2.2% hemolysis at 100 uM (hemo.lytic) (Data from ref for AP3628. This peptide differs from the natural form only by the last Q, which is neutral presumably with a minimal effect on activity). UPdated 10/2023	Pestonjamasp VK, Huttner KH, Gallo RL.2001 Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.||Wang et al., 2023|||Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.||Wang et al., 2023|||Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.||Wang et al., 2023|||11557478|||Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.|||Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.||Wang et al., 2023|||Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.||Wang et al., 2023	34	
FPDB00239	AP03622|||AP03622|||Raniseptin-3	AWLDKLKSIGKVVGKVAIGVAKNLLNPQ	Anti-E. coli ATCC 25922, activity value is MIC = 2 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 1 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 4 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 4 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 8 uM||Anti-and yeast C.albicans ATCC 14053, activity value is MIC > 128 uM||Antibacterial	skin secretion, Chaco tree frog, Boana raniceps, South America|||skin secretion, Chaco tree frog, Boana raniceps, South America|||Hypsiboas raniceps [Chaco tree frog]	Helix	skin secretion, Chaco tree frog, Boana raniceps, South America|||hRBC, low hemo.lytic (20% heolysis at 128 uM; HC50 >128 uM). Toxic to murine skin melanoma B16F10 cells (IC50 6.56 uM) and NIH3T3 mouse fibroblasts cells (IC50 4.21 uM).	Macedo, K.W.R.; Souza, J.O.d.; Castro, J.S.d.; Vasconcelos, I.A.d.; Souza, A.A.; Freitas, S.M.d.; et al. 2023 Biomolecules 2023, 13, 576. https://doi.org/10.3390/biom13030576. MDPI.|||Biomolecules 2023, 13, 576. https://doi.org/10.3390/biom13030576. MDPI.|||Biomolecules 2023, 13, 576. https://doi.org/10.3390/biom13030576. MDPI.|||18976634|||Biomolecules 2023, 13, 576. https://doi.org/10.3390/biom13030576. MDPI.	28	
FPDB00240	AP03621|||AP03621|||Raniseptin-6	ALLDKLKSLGKVVGKVALGVVQNYLNPRQ	Anti-E. coli ATCC 25922, activity value is MIC = 2 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 1 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 4 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 32 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 8 uM||Anti-and yeast C.albicans ATCC 14053, activity value is MIC > 128 uM||Antibacterial	skin secretion, Chaco tree frog, Boana raniceps, South America|||skin secretion, Chaco tree frog, Boana raniceps, South America|||Hypsiboas raniceps [Chaco tree frog]	Helix	skin secretion, Chaco tree frog, Boana raniceps, South America|||hRBC, low hemo.lytic (20% heolysis at 128 uM; HC50 >128 uM). Toxic to murine skin melanoma B16F10 cells (IC50 8.69 uM) and NIH3T3 mouse fibroblasts cells (IC50 5.94 uM).	Macedo, K.W.R.; Souza, J.O.d.; Castro, J.S.d.; Vasconcelos, I.A.d.; Souza, A.A.; Freitas, S.M.d.; et al. 2023 Biomolecules 2023, 13, 576. https://doi.org/10.3390/biom13030576. MDPI.|||Biomolecules 2023, 13, 576. https://doi.org/10.3390/biom13030576. MDPI.|||Biomolecules 2023, 13, 576. https://doi.org/10.3390/biom13030576. MDPI.|||18976634|||Biomolecules 2023, 13, 576. https://doi.org/10.3390/biom13030576. MDPI.	29	
FPDB00241	AP03580	PQAAIVASG	Anti-E.coli MG1655, activity value is MIC > 300 ug/ml||Anti-S.enterica ATCC 14028, activity value is MIC > 300 ug/ml||Anti-P.aeruginosa ATCC 27853, activity value is MIC > 300 ug/ml||Anti-B. cereus ATCC 14893, activity value is MIC = 16 ug/ml||Anti-S. aureus FDA 209 P, activity value is MIC = 4 ug/ml||Anti-and L. monocytogenes EGDe, activity value is MIC = 32.5 ug/ml||Anti-4 strains S. aureus, activity value is MBC = 12.5||Anti-5 strains E. faecium, activity value is MBC = 25||Anti-A. baumannii, activity value is MBC = 25||Anti-K. pneumoniae, activity value is MBC = 25 ug/ml	Emericellopsis alkaline VKPM F1428, Alkalophile, extremophile|||Emericellopsis alkaline VKPM F1428, Alkalophile, extremophile	N/A	Emericellopsis alkaline VKPM F1428, Alkalophile, extremophile|||12.6% hemolysis of hRBC at 20 ug/ml (cf.: 100% lysis by gramicidin S).|||12.6% hemolysis of human RBC at 20 ug/ml (cf.: 100% lysis by gramicidin S).	Rogozhin EA, Sadykova VS, Baranova AA, Vasilchenko AS, Lushpa VA, Mineev KS, Georgieva ML, Kul'ko AB, Krasheninnikov ME, Lyundup AV, Vasilchenko AV, Andreev YA. 2018 Molecules. 2018 Oct 27;23(11):2785. doi: 10.3390/molecules23112785. PubMed|||Molecules. 2018 Oct 27;23(11):2785. doi: 10.3390/molecules23112785. PubMed|||Molecules. 2018 Oct 27;23(11):2785. doi: 10.3390/molecules23112785. PubMed|||Molecules. 2018 Oct 27;23(11):2785. doi: 10.3390/molecules23112785. PubMed	9	
FPDB00242	AP03513|||DRAMP35946	GIFKVLKNLAKGVITSLKS	Anti-E. coli ATCC 25922, activity value is MIC = 6.25 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 3.12 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 1.56 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 6.25 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1.56 uM||Anti-B. megaterium BM11, activity value is MIC < 0.19 uM||Anti-and yeast C. parapsilosis ATCC 22019, activity value is MIC = 3.12 uM||Antimicrobial||Anticancer	derivatives of ocellatin-3N|||derivatives of ocellatin-3N|||derivatives of ocellatin-4N|||Synthetic	N/A	50% hemolysis|||derivatives of ocellatin-3N	Conlon JM, Hunter L, Attoub S, Casciaro B, Mechkarska M, Abdel-Wahab YHA. 2022 J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2023 Apr;29(4):e3466.	19	
FPDB00243	AP03512|||DRAMP35945	GIFDVLKNLAKGVITSLKS	Anti-E. coli ATCC 25922, activity value is MIC = 6.25 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 25 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 1.56 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 25 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 6.25 uM||Anti-B. megaterium BM11, activity value is MIC = 0.19 uM||Anti-and yeast C. parapsilosis ATCC 22019, activity value is MIC = 25 uM||Antimicrobial||Anticancer	derivatives of ocellatin-3N|||Synthetic	N/A	50% hemolysis|||derivatives of ocellatin-3N||It exhibits low hemolytic activity and does not induce the release of lactate dehydrogenase (LDH) at concentrations ≤ 3 uM.|||It exhibits low hemolytic activity and does not induce the release of lactate dehydrogenase (LDH) at concentrations ≤ 3 uM.	Conlon JM, Hunter L, Attoub S, Casciaro B, Mechkarska M, Abdel-Wahab YHA. 2022 J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2023 Apr;29(4):e3465.	19	
FPDB00244	AP03510|||DRAMP35905	LIKKLKEYLKKLI	Anti-Gram- A. baumannii ATCC 003321216, activity value is MIC = 8 ug/ml||Anti-E.coli ATCC 25922, activity value is MIC > 128 ug/ml||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 32||Anti-P.aeruginosa KPC+ 003321199, activity value is MIC > 128 ug/ml||Anti-P. acnes ATCC 51277, activity value is MIC = 64 ug/ml||Anti-Gram+ & Gram-||Antibiofilm||Anticancer||Antimicrobial	derivatives of Latarcin-3a|||Synthetic	N/A	"derivatives of Latarcin-3a|||derivatives of Latarcin-3a||At a concentration of 128 ug/ml, the hemolysis rate is less than 20%.|||The core hemolytic data for the arachnid toxin-derived peptide LTC-3A (parent peptide) and its three analogs (Lt-MAP1, Lt-MAP2, Lt-MAP3) are as follows. The test subjects were Swiss mice musculus erythrocytes, with key indicators being hemolysis rate and half-hemolysis concentration (EC_{50}) at different concentrations: 
 
1. Master peptide: Ltc-3a
 
Specific concentration hemolysis rate: At the highest test concentration of 128 \, \mu g \cdot ml^{-1}, the hemolysis rate reaches 80% (strong hemolysis).  
Half hemolytic concentration (EC_{50}): 127 \, \mu g \cdot ml^{-1} (only the parent peptide has significant hemolytic activity, so this value can be calculated). 
 
2. Analogs: Lt-MAP1, Lt-MAP2, Lt-MAP3
 
The three analogs showed significantly lower hemolytic activity than the parent peptide at concentrations of 4–128 μ g \cdot ml^{-1}, with the core data as follows: 
 
Hemolysis rate: all below 20% (no significant hemolytic activity), not meeting the calculable EC_{50} standard (requires a hemolysis rate of 50%). 
Key conclusion: Even at the highest test concentration of 128 \, \mu g \cdot ml^{-1}, the three analogs maintained low hemolytic levels, with cytotoxicity far lower than that of the parent peptide Ltc-3a. 
 
Additional notes
 
Control settings: The hemolysis rate of the negative control (50,000 uM PBS, pH 7.4) was 0%, and the hemolysis rate of the positive control (1% Triton X-100) was 100%. All data were calibrated based on this. 
Hemolysis and structural association: Analogs reduce hydrophobicity or optimize charge distribution by adjusting amino acid composition (such as replacing methionine with leucine, glutamate with lysine), thereby significantly lowering hemolytic activity while retaining or enhancing antibacterial/antitumor activity (e.g., Lt-MAP2 has both antibacterial and leukemia activity, with Lt-MAP3 optimal).|||At a concentration of 128 ug/ml, the hemolysis rate is less than 20%."	"de Moraes LFRN, Silva PS, Pereira TCPL, Almeida Rodrigues TA, Farias Frihling BE, da Costa RA, Torquato HFV, Lima CS, Paredes-Gamero EJ and Migliolo L 2022
 Front. Microbiol. 13:965621. doi: 10.3389/fmicb.2022.965621. Frontiers Microbiol|||Front. Microbiol. 13:965621. doi: 10.3389/fmicb.2022.965621. Frontiers Microbiol|||Front. Microbiol. 13:965621. doi: 10.3389/fmicb.2022.965621. Frontiers Microbiol|||Front. Microbiol. 13:965621. doi: 10.3389/fmicb.2022.965621. Frontiers Microbiol|||Front Microbiol. 2022 Sep 21;13:965622."	13	
FPDB00245	AP03509|||DRAMP35944	GIFKVLKNLAKGVITSLAS	Anti-E. coli ATCC 25922, activity value is MIC = 1.56 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1.56 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 1.56 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 3.12 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1.56 uM||Anti-B. megaterium BM11, activity value is MIC < 0.19 uM||Anti-and yeast C. parapsilosis ATCC 22019, activity value is MIC = 3.12 uM||Antimicrobial||Anticancer	derivatives of ocellatin-3N|||Synthetic	N/A	"50% hemolysis|||derivatives of ocellatin-3N||The LC₅₀ of the [D4K] analog against mouse red blood cells is greater than 128 uM, while that of the natural peptide is 56±7 uM.|||LC50 values in the range of 12–20 uM、LC50 = 20 uM for human umbilical vein endothelial cells
(HUVECs)|||The LC₅₀ of the [D4K] analog against mouse red blood cells is greater than 128 uM, while that of the natural peptide is 56±7 uM."	Conlon JM, Hunter L, Attoub S, Casciaro B, Mechkarska M, Abdel-Wahab YHA. 2022 J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2022 Nov 24:e3463. doi: 10.1002/psc.3463. PubMed||Conlon et al., 2022|||J Pept Sci. 2023 Apr;29(4):e3464.	19	
FPDB00246	AP03425|||DRAMP35857	GLLGKILGAGKKVLCGVSGLC	Anti-788, activity value is MIC = 4 uM||Anti-923, activity value is MIC = 16 uM||Anti-MRSA B042 V2E1A, activity value is MIC = 16||Anti-697, activity value is MIC = 8 uM||Anti-S. constellatus B003 VISIT, activity value is MIC = 8 uM||Anti-418, activity value is MIC = 8 uM||Anti-816, activity value is MIC = 16 uM||Anti-P. aeruginosa ATCC 9097, activity value is MIC = 64 uM||Anti-P. aeruginosa B004 V2S2B, activity value is MIC = 16 uM||Anti-and fungus C. albicans NYCY 1467, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Antimicrobial	Pelophylax nigromaculatus, Asia|||Animalia	Helix	Pelophylax nigromaculatus, Asia	Chengyu Lu, Lingling Liu, Chengbang Ma, Liuqing Di, Tianbao Chen 2022 Journal of Genetic Engineering and Biotechnology 2022; 20:76. Publisher Web|||Journal of Genetic Engineering and Biotechnology 2022; 20:76. Publisher Web|||J Genet Eng Biotechnol. 2022 May 23;20(1):76.|||Journal of Genetic Engineering and Biotechnology 2022; 20:76. Publisher Web	21	
FPDB00247	AP03347	GVITDALKGAAKTVAAELLKKAHCKLTNSC	Weakly active against Gram+ and Gram- bacteria and fungi. This peptide can also brevinin- 2KP can promote degranulation and histamine release from mast cells. To be updated.	Skin, the banded bullfrog, common Asian frog, Kaloula pulchra, Asia	Helix	Skin, the banded bullfrog, common Asian frog, Kaloula pulchra, Asia	"Gao Y, Chai J, Wu J, Zeng Q, Guo R, Chen X, Xu X. 2022 Curr Pharm Biotechnol. 2022;23(15):1873-1882. doi: 10.2174/1389201023666220304204645. PubMed|||Curr Pharm Biotechnol
. 2022;23(15):1873-1882. doi: 10.2174/1389201023666220304204645."	30	
FPDB00248	AP03307|||AP03307|||T-DPH1|||T-DPH1|||AP03307|||DRAMP35817	GLWSKIKNVAAAAGKAALGAL	Anti-S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 8||Anti-E.faecalis NCTC 12697, activity value is MIC = 128 uM||Anti-E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 16 uM||Anti-C. albicans ATCC 10231, activity value is MIC = 64 uM||Anti-H157 and U251MG, activity value is IC50 = 10.2||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Anti-S. aureus ATCC 6538, activity value is MIC = 8 uM||Anti-Methicillin-resistant Staphylococcus aureus NCTC 12493, activity value is MIC = 16 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MIC = 128 uM||Antimicrobial	skin secretion, the northern orange-legged leaf frog, tiger-legged monkey frog, Phyllomedusa hypochondrialis, South America|||Phyllomedusa hypochondrialis [orange-legged leaf frog]|||Animalia|||skin secretion, the northern orange-legged leaf frog, tiger-legged monkey frog, Phyllomedusa hypochondrialis, South America	Helix	"skin secretion, the northern orange-legged leaf frog, tiger-legged monkey frog, Phyllomedusa hypochondrialis, South America|||Horse RBC [HC50= 106.4 uM]|||The key value related to hemolysis in this study is the half-maximal hemolytic concentration (HC₅₀), with horse red blood cells as the test subject. The specific data are as follows:

The parent peptide t-DPH1 has an HC₅₀ of 106.4 μM, and its hemolysis rate exceeds 50% at a high concentration (100 μM);
Analogue t-DPH1-K4 has an HC₅₀ of 444.8 μM, which is 4 times that of the parent peptide;
Analogue t-DPH1-5K has an HC₅₀ of 19.39 μM, and is the only analogue with increased hemolytic activity, approximately 5 times that of the parent peptide, with a hemolysis rate approaching 40% at 10 μM concentration;
Analogue t-DPH1-6K has an HC₅₀ of 834.6 μM, 8 times that of the parent peptide;
Analogue t-DPH1-6KW has an HC₅₀ of 2094 μM, showing the lowest hemolytic activity, with almost no hemolysis observed at the tested concentrations.

Except for t-DPH1-5K, all other designed analogues have lower hemolytic activity than the parent peptide at the tested concentrations.|||Horse RBC [HC50= 106.4 uM]"	"Qin H, Fang H, Chen X, Wang L, Ma C, Xi X, Chen T, Shaw C, Zhou M. 2021 Antibiotics (Basel). 2021 Dec 14;10(12):1529. doi: 10.3390/antibiotics10121529. PubMed|||Microb Genom
. 2017 Sep 25;3(10):e000134. doi: 10.1099/mgen.0.000134. eCollection 2017 Oct.|||Microb Genom
. 2017 Sep 25;3(10):e000134. doi: 10.1099/mgen.0.000134. eCollection 2017 Oct.|||34943741|||Antibiotics (Basel). 2021 Dec 14;10(12):1529. doi: 10.3390/antibiotics10121529. PubMed|||34943741|||Microb Genom
. 2017 Sep 25;3(10):e000134. doi: 10.1099/mgen.0.000134. eCollection 2017 Oct.|||Antibiotics (Basel). 2021 Dec 14;10(12):1529.|||Antibiotics (Basel). 2021 Dec 14;10(12):1529. doi: 10.3390/antibiotics10121529. PubMed"	21	
FPDB00249	AP03305|||DRAMP32354	FLPLLISALTSLFPKLGK	In HSC-4 cells||SSTP1 induces growth inhibition with an IC50 value of 10.22 uM.||Antimicrobial||Anticancer	skin secretion, the golden frog, the Trivandrum frog, the common wood frog, or the small wood frog, Indosylvirana aurantiaca, India, Asia|||Skin Secretion of Indosylvirana aurantiaca	N/A	hemolysis at 5000 uM	Gopalakrishnan S, Uma SK, Mohan G, Mohan A, Shanmugam G, Kumar VTV, J S, Chandrika SK, Vasudevan D, Nori SRC, Sathi SN, George S, Maliekal TT 2021 Front Immunol. 2021 Nov 19;12:740620. doi: 10.3389/fimmu.2021.740620. PubMed|||Front Immunol. 2021 Nov 19;12:740620.	18	
FPDB00250	AP03301|||AP03301|||Esculentin 2 HYba2|||E2/2-NH2|||DRAMP35675	SILSLFKMGAKALGKTLIKQAGKAGAEYVACKATNQC	Anti-C-terminal amidated form: active against Gram+ S. aureus MTCC 9542 or MRSA ATCC 43300, activity value is MIC = 1.5||Anti-B. subtilis MTCC 14416, activity value is MIC = 15 uM||Anti-B. coagulans ATCC 7050, activity value is MIC = 10 uM||Anti-VRE ATCC 29212, activity value is MIC = 12 uM||Anti-S. mutans MTCC 497, activity value is MIC = 5 uM||Anti-S. gordonnii MTCC 2695, activity value is MIC = 5 uM||Anti-V. cholerae MCV09, activity value is MIC = 7 uM||Anti-E. coli ATCC 25922, activity value is MIC = 10 uM||Anti-fish pathogens A. hydrophilia, activity value is MIC = 20 uM||Anti-A. sobria, activity value is MIC = 3 uM||Anti-Gram+ & Gram-||Anti-MRSA||Hemolytic||Anticancer||Antibacterial||Antimicrobial	skin secretion, Hydrophylax bahuvistara, India, Asia|||H. bahuvistara [ Fungoid frog]|||Synthetic construct|||Synthetic	N/A	"In this document, the key values related to hemolysis of the novel antimicrobial peptides derived from the skin of the frog species endemic to the Western Ghats of India (Hydrophylax bahuvistara)—Esculentin-2 HYba1 (E2/1), Esculentin-2 HYba2 (E2/2), and their C-terminal amidated analogues (E2/1 CONH₂, E2/2 CONH₂)—are as follows. These were determined by red blood cell hemolysis assays (red blood cell source not specified, commonly horse or human red blood cells; PBS as 0% hemolysis negative control, 1% Triton X-100 as 100% hemolysis positive control):

Core hemolytic activity results:

- Testing background: Covering the antibacterial effective concentrations of four peptides (e.g., MIC of E2/1 against Staphylococcus aureus = 3 μM, against Vibrio cholerae = 9 μM; the amidated analogue E2/1 CONH₂ against Aeromonas hydrophila = 15 μM).

- Hemolytic values of each peptide:

1. Esculentin-2 HYba1 (E2/1, natural peptide):

- Half-maximal hemolysis concentration (HC₅₀): 10–15 μM, relatively high hemolytic activity, partially overlapping with its antibacterial effective concentration range (3–100 μM), indicating safety needs optimization.

2. Esculentin-2 HYba2 (E2/2, natural peptide):

- HC₅₀: 10–15 μM, consistent with E2/1 in hemolytic activity, no significant difference.

3. E2/1 CONH₂ (C-terminal amidated analogue):

- HC₅₀: 10–15 μM, amidation modification did not change hemolytic activity. Although antibacterial activity (e.g., MIC against fish pathogen Aeromonas hydrophila decreased from 100 μM to 15 μM) and killing speed (killing time against Staphylococcus aureus reduced from 3 hours to 10 minutes) are significantly improved, hemolytic toxicity remains unchanged.

4. E2/2 CONH₂ (C-terminal amidated analogue):

- HC₅₀: 10–15 μM, consistent with natural peptides E2/2 and E2/1 CONH₂ in hemolytic activity, with no additional hemolysis risk.|||skin secretion, Hydrophylax bahuvistara, India, Asia|||hRBC (HC50 = 10 uM)|||hRBC (HC50 = 12 uM)"	"Vineeth Kumar T, Asha R, George S.2021 Nat Prod Res. 2021 Apr;35(8):1262-1266. doi: 10.1080/14786419.2019.1644636. PubMed|||Nat Prod Res
. 2021 Apr;35(8):1262-1266. doi: 10.1080/14786419.2019.1644636. Epub 2019 Jul 22.|||Nat Prod Res
. 2021 Apr;35(8):1262-1266. doi: 10.1080/14786419.2019.1644636. Epub 2019 Jul 22.|||31328553|||Nat Prod Res. 2021 Apr;35(8):1262-1266."	37	
FPDB00251	AP03300|||AP03300|||Esculentin 2 HYba1|||E2/1-NH2	SIFSLFKMGAKALGKTLLKQAGKAGAEYAACKATNQC	Anti-C-terminal amidated form: active against Gram+ S. aureus MTCC 9542 or MRSA ATCC 43300, activity value is MIC = 1||Anti-B. subtilis MTCC 14416, activity value is MIC = 7 uM||Anti-B. coagulans ATCC 7050, activity value is MIC = 10 uM||Anti-VRE ATCC 29212, activity value is MIC = 10 uM||Anti-S. mutans MTCC 497, activity value is MIC = 7 uM||Anti-S. gordonnii MTCC 2695, activity value is MIC = 5 uM||Anti-V. cholerae MCV09, activity value is MIC = 6 uM||Anti-E. coli ATCC 25922, activity value is MIC = 10 uM||Anti-fish pathogens A. hydrophilia, activity value is MIC = 15 uM||Anti-A. sobria, activity value is MIC = 1.5 uM||Anti-Gram+ & Gram-||Anti-MRSA||Hemolytic||Anticancer||Antibacterial	skin secretion, Hydrophylax bahuvistara, India, Asia|||H. bahuvistara [ Fungoid frog]|||Synthetic construct	N/A	"In this document, the key values related to hemolysis of the novel antimicrobial peptides derived from the skin of the frog species endemic to the Western Ghats of India (Hydrophylax bahuvistara)—Esculentin-2 HYba1 (E2/1), Esculentin-2 HYba2 (E2/2), and their C-terminal amidated analogues (E2/1 CONH₂, E2/2 CONH₂)—are as follows. These were determined by red blood cell hemolysis assays (red blood cell source not specified, commonly horse or human red blood cells; PBS as 0% hemolysis negative control, 1% Triton X-100 as 100% hemolysis positive control):

Core hemolytic activity results:

- Testing background: Covering the antibacterial effective concentrations of four peptides (e.g., MIC of E2/1 against Staphylococcus aureus = 3 μM, against Vibrio cholerae = 9 μM; the amidated analogue E2/1 CONH₂ against Aeromonas hydrophila = 15 μM).

- Hemolytic values of each peptide:

1. Esculentin-2 HYba1 (E2/1, natural peptide):

- Half-maximal hemolysis concentration (HC₅₀): 10–15 μM, relatively high hemolytic activity, partially overlapping with its antibacterial effective concentration range (3–100 μM), indicating safety needs optimization.

2. Esculentin-2 HYba2 (E2/2, natural peptide):

- HC₅₀: 10–15 μM, consistent with E2/1 in hemolytic activity, no significant difference.

3. E2/1 CONH₂ (C-terminal amidated analogue):

- HC₅₀: 10–15 μM, amidation modification did not change hemolytic activity. Although antibacterial activity (e.g., MIC against fish pathogen Aeromonas hydrophila decreased from 100 μM to 15 μM) and killing speed (killing time against Staphylococcus aureus reduced from 3 hours to 10 minutes) are significantly improved, hemolytic toxicity remains unchanged.

4. E2/2 CONH₂ (C-terminal amidated analogue):

- HC₅₀: 10–15 μM, consistent with natural peptides E2/2 and E2/1 CONH₂ in hemolytic activity, with no additional hemolysis risk.|||skin secretion, Hydrophylax bahuvistara, India, Asia|||hRBC (HC50 = 10 uM)|||hRBC (HC50 = 15 uM)"	"Vineeth Kumar T, Asha R, George S.2021 Nat Prod Res. 2021 Apr;35(8):1262-1266. doi: 10.1080/14786419.2019.1644636. PubMed|||Nat Prod Res
. 2021 Apr;35(8):1262-1266. doi: 10.1080/14786419.2019.1644636. Epub 2019 Jul 22.|||Nat Prod Res
. 2021 Apr;35(8):1262-1266. doi: 10.1080/14786419.2019.1644636. Epub 2019 Jul 22.|||31328553"	37	
FPDB00252	AP03279|||AP03279|||Pituitary adenylate cyclase-activating polypeptide, PACAP-38|||Pituitary adenylate cyclase-activating polypeptide, PACAP-38|||AP03279|||DRAMP32144	HSDGIFTDSYSRYRKQMAVKKYLAAVLGRRYRQRFRNK	Anti-fish Gram- pathogens Y. ruckeri, activity value is MIC = 50 uM||Anti-A. salmonicida, activity value is MIC = 50 uM||Anti-human bacteria B. subtilis, activity value is MIC = 5 uM||Anti-and C. albicans, activity value is MIC = 75 uM||Anti-S.aureus, activity value is MIC > 300 uM||Anti-P.aeruginosa, activity value is MIC = 300 uM||Anti-E.coli, activity value is MIC > 300 uM||Anti-and Salmonella sp, activity value is MIC = 300 uM||Antibacterial||Antifungal||Anti-Yersinia ruckeri 4319/03, activity value is MIC = 50 uM||Anti-Yersinia ruckeri 4319/03, activity value is IC50 = 0.023 uM||Anti-Aeromonas hydrophila 4387/12, activity value is MIC = 300 uM||Anti-Aeromonas hydrophila 4387/12, activity value is IC50 = 7.2 uM||Anti-Aeromonas sobria 02/12, activity value is MIC = 100 uM||Anti-Aeromonas sobria 02/12, activity value is IC50 = 28.6 uM||Anti-Aeromonas salmonicida 4387/12, activity value is MIC = 50 uM||Anti-Bacillus subtilis ATCC 6333, activity value is MIC = 5 uM||Anti-Bacillus subtilis ATCC 6333, activity value is IC50 = 0.76 uM||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC > 300 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 300 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is IC50 = 54.4 uM||Anti-Escherichia coli ATCC 8739, activity value is MIC > 300 uM||Anti-Escherichia coli ATCC 8739, activity value is IC50 = 46.6 uM||Anti-Salmonella sp, activity value is MIC = 300 uM||Anti-Salmonella sp, activity value is IC50 = 116.8 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 75 uM||Anti-Candida albicans ATCC 10231, activity value is IC50 = 36.9 uM||Anti-Human lung carcinoma NCI-H460, activity value is IC50 = 14.97||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||candidacidal	Clarias gariepinus, North Africa|||Clarias gariepinus|||Clarias gariepinus|||Clarias gariepinus, North Africa|||Synthetic	N/A	Clarias gariepinus, North Africa|||Human erythrocytes (0% Hemolysis at <75 uM|||Human erythrocytes (0% Hemolysis at <75 uM|||Human red blood cells: PACAP was not hemolytic for human erythrocytes at concentrations below 75 uM (0% hemolysis). At concentration between 75 uM and 150 uM the hemolytic activity was less than 3%; Fish red blood cells:PACAP was not hemolytic for fish red blood cells at concentrations below 18.75 uM (0% hemolysis). At concentration between 18.75 uM and 150 uM, the hemolytic activity was less than 20%|||Interestingly, catfish PACAP was less cytotoxic for human cells than for fish cells. In any case, the hemolytic activity reached 50% hemolysis (Fig. 4A and B). PACAP was not hemolytic for fish red blood cells at concentrations below 18.75 uM (0% hemolysis). At concentration between 18.75 uM and 150 uM, the hemolytic activity was less than 20%. PACAP reached a top value of 39% hemolysis at the highest concentration analyzed (300 uM) (Fig. 4A). On the other hand, PACAP was not hemolytic for human erythrocytes at concentrations below 75 uM (0% hemolysis). At concentration between 75 uM and 150 uM the hemolytic activity was less than 3%. PACAP reached a top value of 6% hemolysis at the highest concentration analyzed (300 uM) (Fig. 4B).	"Lugo JM, Tafalla C, Oliva A, Pons T, Oliva B, Aquilino C, Morales R, Estrada MP. 2018 Fish Shellfish Immunol. 2019 Mar;86:559-570. doi: 10.1016/j.fsi.2018.11.056. PubMed|||Fish Shellfish Immunol
. 2019 Mar:86:559-570. doi: 10.1016/j.fsi.2018.11.056. Epub 2018 Nov 24.|||30481557|||30481557|||Fish Shellfish Immunol
. 2019 Mar:86:559-570. doi: 10.1016/j.fsi.2018.11.056. Epub 2018 Nov 24.|||Fish Shellfish Immunol. 2019 Mar;86:559-570.|||Fish Shellfish Immunol. 2019 Mar;86:559-570. doi: 10.1016/j.fsi.2018.11.056. PubMed"	38	
FPDB00253	AP03251|||AP03251|||Ocellatin-3N|||DRAMP35943	GIFDVLKNLAKGVITSLAS	Anti-antibiotic-resistant K. pneumoniae ATCC 49472 or ATCC BAA-2814, activity value is MIC = 62.5 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 62.5 uM||Anti-S. typhimurium ATCC 14028, activity value is MIC = 62.5 uM||Anti-S. aureus ATCC 12600 or ATCC 25923 or ATCC BAA-2312, activity value is MIC = 12.5||Anti-E. faecium ATCC 19434, activity value is MIC = 62.5 uM||Anti-and E.faecalis ATCC 51299, activity value is MIC = 250 uM||Anti-E. coli ATCC 25922, activity value is MIC = 6.25 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 25 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 6.25 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 6.25 uM||Anti-B. megaterium BM11, activity value is MIC = 0.78 uM||Anti-and a strain of the major emerging yeast pathogen C. parapsilosis ATCC 22019, activity value is MIC = 25 uM||Antibacterial ; Synthetic construct||Anti-Staphylococcus aureus ATCC 12600, activity value is MIC = 31.25 uM||Anti-Staphylococcus aureus ATCC BAA-2312, activity value is MIC = 31.25 uM||Anti-Enterococcus faecium ATCC 19434, activity value is MIC = 62.5 uM||Anti-Enterococcus faecalis ATCC 51299, activity value is MIC = 250 uM||Anti-Escherichia coli ATCC 35218, activity value is MIC = 31.25 uM||Anti-Klebsiella pneumoniae ATCC 49472, activity value is MIC = 62.5 uM||Anti-Klebsiella pneumoniae ATCC BAA-2814, activity value is MIC = 62.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 62.5 uM||Anti-Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028, activity value is MIC = 62.5 uM||Antimicrobial||Anticancer	Skin Secretions, the Caribbean frog, Leptodactylus nesiotus, South America|||Synthetic construct|||Synthetic	N/A	50% hemolysis in three independent experiments.|||Skin Secretions, the Caribbean frog, Leptodactylus nesiotus, South America|||Staphylococcus aureus ATCC 12600[MIC = 31.25 uM], Staphylococcus aureus ATCC BAA-2312[MIC = 31.25 uM], Enterococcus faecium ATCC 19434[MIC = 62.5 uM], Enterococcus faecalis ATCC 51299[MIC = 250 uM], Escherichia coli ATCC 35218[MIC = 31.25 uM], Klebsiella pneumoniae ATCC 49472[MIC = 62.5 uM], Klebsiella pneumoniae ATCC BAA-2814[MIC = 62.5 uM], Pseudomonas aeruginosa ATCC 27853[MIC = 62.5 uM], Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028[MIC = 62.5 uM]||Mouse erythrocytes (50% Hemolysis at 98 uM|||Mouse erythrocytes (50% Hemolysis at 98 uM	"Barran G, Kolodziejek J, Coquet L, Leprince J, Jouenne T, Nowotny N, Conlon JM, Mechkarska M. 2020 Antibiotics (Basel). 2020 Oct 20;9(10):718. doi: 10.3390/antibiotics9100718.PubMed|||Antibiotics (Basel)
. 2020 Oct 20;9(10):718. doi: 10.3390/antibiotics9100718|||https://pubmed.ncbi.nlm.nih.gov/33092132|||Antibiotics (Basel)
. 2020 Oct 20;9(10):718. doi: 10.3390/antibiotics9100718|||J Pept Sci. 2023 Apr;29(4):e3463."	19	
FPDB00254	AP03248|||AP03248|||Figainin 1|||DRAMP32309	FIGTLIPLALGALTKLFK	Anti-bacteria and parasites. Inhibits Gram+ E. faecalis ATCC 29212, activity value is MIC = 8 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 4 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 2 uM||Anti-E. casseliflavus ATCC 700327, activity value is MIC = 16 uM||Anti-E. coli ATCC 25922, activity value is MIC = 16 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 4 uM||Anti-and parasite T. cruzi, activity value is IC50 = 15.9 uM||activity value is IC50 = 10||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 8 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 2 uM||Anti-Enterococcus casseliflavus ATCC 700327, activity value is MIC = 16 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 16 uM||Anti-Klebsiella pneumoniae ATCC 13883, activity value is MIC = 4 uM||Antimicrobial||Anticancer	skin secretions, Chaco tree frog, Boana raniceps, South America|||Boana raniceps|||B. raniceps skin secretion|||B. raniceps skin secretion	Helix	skin secretions, Chaco tree frog, Boana raniceps, South America|||Human erythrocytes (50% Hemolysis at 10 uM|||Human red blood cells: HC50 =10 uM (19 ug/ml) (testing time is 24 h)	"Santana CJC, Magalhães ACM, Dos Santos Júnior ACM, Ricart CAO, Lima BD, Álvares ADCM, Freitas SM, Pires OR Jr, Fontes W, Castro MS.2020 Antibiotics (Basel). 2020 Sep 21;9(9):625. doi: 10.3390/antibiotics9090625. PubMed|||Antibiotics (Basel)
. 2020 Sep 21;9(9):625. doi: 10.3390/antibiotics9090625.|||32967114|||Antibiotics (Basel)
. 2020 Sep 21;9(9):625. doi: 10.3390/antibiotics9090625.|||Antibiotics (Basel). 2020 Sep 21;9(9):625"	18	
FPDB00255	AP03239|||AP03239|||Phylloseptin-PTa|||Phylloseptin-PTa|||AP03239|||DRAMP32064	FLSLIPKIAGGIAALAKHL	Anti-S. aureus NCTC 10788, activity value is MIC = 4.14 uM||Anti-E. faecalis NCTC 12697, activity value is MIC = 16.56 uM||Anti-E. coli NCTC 10418, activity value is MIC = 16.56 uM||Anti-C. albicans NCYC 1467, activity value is MIC = 2.07 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Antibiofilm||Anticancer||Anti-S. aureus NCTC 10788, activity value is MIC = 64 ug/ml||Anti-MRSA NCTC 12493, activity value is MIC = 64 ug/ml||Anti-E. faecalis NCTC 12697, activity value is MIC = 512 ug/ml||Anti-C. albicans NCYC 1, activity value is MIC = 256 ug/ml||Antimicrobial	skin secretions, the Brown-bellied Leaf Frog, Phyllomedusa tarsius, South America|||Phyllomedusa tarsius [Brownbelly leaf frog]|||Phyllomedusa baltea|||skin secretions, the Brown-bellied Leaf Frog, Phyllomedusa tarsius, South America	Helix	"skin secretions, the Brown-bellied Leaf Frog, Phyllomedusa tarsius, South America|||Horse erythrocytes (HC50= 22.8 uM)|||The document clearly provides detailed hemolytic data for two types of antimicrobial peptides in leaf frogs (phylloseptin-PTa and phylloseptin-PHa), with the core information as follows: 
 
1. Key hemolytic markers (Tsushima erythrocytes)
 
The hemolytic properties of the two peptides were measured by hemolysis rates at half the hemolytic concentration (HC₅₀), 10% hemolytic concentration (HC₁₀), and minimum inhibitory concentration (MIC). Specific data are shown in Table 2: 
 
Peptide Name Hemolytic Rate at S. aureus MIC HC₁₀(uM) HC₅₀(uM) 
phylloseptin-PTa 4.42% 7.79 22.8 
phylloseptin-PHa 2.52% 76.5 109.5 
 
- HC₁₀: The concentration of peptides inducing 10% red blood cell hemolysis; the higher the value, the lower the hemolytic activity at lower concentrations; 
- HC₅₀: The concentration of peptides inducing 50% hemolysis of red blood cells; the higher the value, the lower the overall hemolysis; 
- Both have hemolytic rates below 5% at MIC concentrations targeting Staphylococcus aureus (S. aureus), with phylloseptin-PHa being only 2.52%, indicating lower hemolytic toxicity. 
 
2. Experimental Background and Safety Verification
 
- Experimental method: 4% red blood cell suspension was prepared from defibrotic horse blood and incubated with peptides of different concentrations (1~512 uM) at 37°C for 2 hours. The absorbance of the supernatant at 550 nm (reflecting hemoglobin release) was measured. The 2% Triton X-100 treatment group was used as the 100% hemolytic positive control and 1% DMSO/PBS as the solvent control. The hemolysis rate was calculated using formulas. 
- Security Comparison: 
1. The hemolytic properties of both peptides are significantly lower than those of most highly toxic antimicrobial peptides (for example, some frog-derived peptides have hemolytic rates exceeding 10% under MIC); 
2. Combined with treatment index (TI) analysis (Table 3), the ratio of HC₁₀ to MIC/MBEC (minimum biofilm clearance concentration) for inhibiting Gram-positive bacteria and clearing Staphylococcus aureus biofilms was greater than 1, indicating a low risk of hemolysis at effective antibacterial concentrations; 
3. Cytotoxicity tests on human microvascular endothelial cells (HMEC-1) showed that phylloseptin-PHa showed mild toxicity at test concentrations, while phylloseptin-PTa showed significant toxicity only at 100 uM, further confirming their safety against normal mammalian cells. 
 
In summary, both types of antimicrobial peptides in leaf frogs exhibit low hemolytic characteristics, with phylloseptin-PHa having lower hemolytic activity, providing important safety evidence for its use as an anti-infective drug candidate.|||Horse erythrocytes (HC50= 22.8 uM)|||Horse erythrocytes: 10% Hemolysis=7.79 uM; 50% Hemolysis=22.8 uM"	"Liu J, Wu Q, Li L, Xi X, Wu D, Zhou M, Chen T, Shaw C, Wang L.2017 Molecules. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428. PubMed|||Molecules
. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428.|||Molecules
. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428.|||28850103|||Molecules. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428. PubMed|||28850103|||Molecules
. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428.|||Molecules. 2017 Aug 29;22(9):1428.|||Molecules. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428. PubMed"	19	
FPDB00256	AP03235|||DRAMP03529	RWKLFKKIEKVGRNVRDGLIKAGPAIAVIGQAKSL	A recombinant form was found to be active against B. subtilis and L. monocytogenes (Lee et a;.||2013).||Antimicrobial||Antibacterial	silkworm, Bombyx mori|||Bombyx mori (Silk moth)	N/A	silkworm, Bombyx mori	"Morishima I, Suginaka S, Ueno T, Hirano H. 1990 Comp Biochem Physiol B. 1990;95(3):551-4. doi: 10.1016/0305-0491(90)90019-p. PubMed|||Comp Biochem Physiol B
. 1990;95(3):551-4. doi: 10.1016/0305-0491(90)90019-p.|||Biosci Biotechnol Biochem. 1994 Aug;58(8):1476-1478."	35	
FPDB00257	AP03224|||AP03224|||Dermaseptin PD-2|||Dermaseptin PD-2|||AP03224	GMWSKIKNAGKAAAKAAAKAAGKAALDAVSEAI	Anti-Strongly active against E. coli, activity value is MIC = 5 uM||Anti-S. aureus, activity value is MIC = 5 uM||Anti-P. aeruginosa, activity value is MIC = 2.5 uM||Antibacterial||Antifungal||Anti-Escherichia coli NCTC 10418, activity value is MIC = 5 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 20.2 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 5 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 10.1 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 10.1 uM||Anti-Candida albicans NCPF 1467, activity value is MBC = 20.2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 2.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 10.1 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 13.43 uM||Anti-Human squamous lung carcinoma NCI-H157, activity value is IC50 = 6.43 uM||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 3.17 uM||Anti-Gram+ & Gram-||candidacidal||Anticancer	Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Pachymedusa dacnicolor|||Pachymedusa dacnicolor|||Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Skin Secretion, Pachymedusa dacnicolor, Mexico, North America	Rich	Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Horse erythrocytes (- at NA|||Horse erythrocytes (- at NA	"Shi D, Hou X, Wang L, Gao Y, Wu D, Xi X, Zhou M, Kwok HF, Duan J, Chen T, Shaw C. 2016 Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144. PubMed|||Toxins (Basel)
. 2016 May 12;8(5):144. doi: 10.3390/toxins8050144.|||27187467|||27187467|||Toxins (Basel)
. 2016 May 12;8(5):144. doi: 10.3390/toxins8050144.|||Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144. PubMed"	33	
FPDB00258	AP03223|||AP03223|||Dermaseptin PD-1|||Dermaseptin PD-1|||AP03223	GMWSKIKETAMAAAKEAAKAAGKTISDMIKQ	Anti-E. coli, activity value is MIC = 19.6 uM||Anti-S. aureus, activity value is MIC = 39.2 uM||Anti-P. aeruginosa, activity value is MIC = 19.6 uM||Antibacterial||Antifungal||Anti-Escherichia coli NCTC 10418, activity value is MIC = 19.6 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 39.2 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 39.2 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 78.4 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 39.2 uM||Anti-Candida albicans NCPF 1467, activity value is MBC = 78.4 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 19.6 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 78.4 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 15.08 uM||Anti-Gram+ & Gram-||candidacidal||Anticancer	Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Pachymedusa dacnicolor|||Pachymedusa dacnicolor|||Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Skin Secretion, Pachymedusa dacnicolor, Mexico, North America	N/A	Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Horse erythrocytes (- at NA|||Horse erythrocytes (- at NA	"Shi D, Hou X, Wang L, Gao Y, Wu D, Xi X, Zhou M, Kwok HF, Duan J, Chen T, Shaw C. 2016  Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144. PubMed|||Toxins (Basel)
. 2016 May 12;8(5):144. doi: 10.3390/toxins8050144.|||27187467|||27187467|||Toxins (Basel)
. 2016 May 12;8(5):144. doi: 10.3390/toxins8050144.|||Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144. PubMed"	31	
FPDB00259	AP03219|||AP03219|||Kassiniatuerin-3|||Kassiniatuerin-3|||AP03219|||DRAMP32285	FIQHLIPLIPHAIQGIKDIF	Anti-moderately to weakly active against S. aureus, activity value is MIC = 16||Anti-MRSA, activity value is MIC = 32||Anti-E.faecalis, activity value is MIC = 128 uM||Anti-E.coli, activity value is MIC > 512 uM||Anti-and C. albicans, activity value is MIC = 64||Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 16||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 32||Anti-Escherichia coli NCTC 10418, activity value is MIC > 512 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC > 512 uM||Anti-Candida albicans NCYC 1467, activity value is MIC = 64||Anti-Candida albicans NCYC 1467, activity value is MFC = 128 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MIC = 32||Anti-Staphylococcus aureus NCTC 12493, activity value is MBC = 64||Anti-Enterococcus faecalis NCTC 12697, activity value is MIC = 128 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MBC = 128 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 512 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC > 512 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 13.2 uM||Anti-Human prostate adenocarcinoma LNCaP, activity value is IC50 = 3.79 uM||Anti-Human lung adenocarcinoma NCI-H838, activity value is IC50 = 10.03 uM||Anti-Human lung carcinoma NCI-H460, activity value is IC50 = 1.67 uM||Anti-Human squamous lung carcinoma NCI-H157, activity value is IC50 = 21.54 uM||Anti-Human lung adenocarcinoma NCI-H23, activity value is IC50 = 4.52 uM||Antimicrobial	Kassina senegalensis, Africa|||Kassina senegalensis|||Skin Secretion of the African Frog, Kassina senegalensis|||Skin Secretion of the African Frog, Kassina senegalensis	Helix	"50% hemolysis at a concentration of 65000000 uM|||In this document, the key information related to the hemolytic activity of a novel antimicrobial peptide Kassinatuerin-3, derived from the skin of the African frog (Kassina senegalensis), is as follows, as determined by the horse red blood cell hemolysis assay (0.1% Triton X-100 as 100% hemolytic positive control, PBS as 0% hemolytic negative control):

Core Hemolytic Activity Results

- Tested concentration range: 5–160 μM (covering its effective antimicrobial concentrations, such as MIC against Staphylococcus aureus = 16–32 μM, MIC against MRSA = 32–64 μM)

- Kassinatuerin-3 hemolysis values:

- No hemolysis at low concentrations: No significant hemolytic activity was detected at concentrations of 160 μM and below (hemolysis rate <1%). This concentration is far higher than the effective antimicrobial concentration against Gram-positive bacteria (16–64 μM), indicating almost no hemolytic toxicity during antimicrobial activity.

- Slight hemolysis at high concentrations: Slight hemolysis only occurred when concentrations exceeded 160 μM; however, the document did not mention the exact hemolysis rates at specific higher concentrations (e.g., 256 μM, 512 μM).

- Comparison with homologous peptides and positive control:

- The homologous peptide Kassinatuerin-2Ma (from Kassina maculata) showed a hemolysis rate of 40%–50% at 120 μM, whereas Kassinatuerin-3 showed no hemolysis at 160 μM, indicating significantly lower hemolytic toxicity;

- The positive control melittin, although exhibiting strong antimicrobial activity (MIC against Staphylococcus aureus = 1–2 μM), has extremely high hemolytic toxicity and lacks clinical safety, whereas Kassinatuerin-3 demonstrates a higher therapeutic index (ratio of antimicrobial activity to hemolytic toxicity).|||Kassina senegalensis, Africa||At a concentration of up to 160 μM, Kassinatuerin-3 did not show detectable hemolytic activity, with slight activity observed above this concentration. Kassinatuerin-1, which has a net charge of +2, has a MIC of 6.25 μM against Staphylococcus aureus, but induces 50% hemolysis at a concentration of 65 μM.|||Horse erythrocytes (2.5% Hemolysis at 160 uM|||The document clearly provides the hemolytic data of the novel antimicrobial peptide Kassinatuerin-3 on equine red blood cells. The core information is as follows:

1. Critical hemolytic value (for equine red blood cells)

Core characteristics: Kassinatuerin-3 hemolysis is very weak, no obvious hemolytic activity at most concentrations tested in the experiment.
At concentrations ≤ 160 uM: no detectable hemolytic activity (hemolysis ratio ≈ 0%).
At concentrations&gt; 160 uM: showed only slight hemolytic activity (specific values not explicitly quantified but significantly lower than the positive control).

2. Experimental Controls and Supplementary Notes

Comparison settings:
Negative control (PBS treatment): No hemolysis (hemolysis rate = 0%).
Positive control (0.1% Triton X-100 treatment): complete hemolysis (hemolysis rate = 100%), used to calibrate the detection system.
The correlation between hemolytic activity and antibacterial activity:
The minimum inhibitory concentration (MIC) of Kassinatuerin-3 against gram-positive bacteria (such as S. aureus and MRSA) is 16-64 uM, and the minimum bactericidal concentration (MBC) is 32-128 uM, which are far lower than the concentration (&gt;160 uM) that produces slight hemolysis, reflecting a high therapeutic index (high ratio of antibacterial activity to hemolytic toxicity).
Comparison with similar peptides:
The Kassinatuerin-2Ma of the same genus (net charge is the same as that of the Kassinatuerin-3, both are +1) has a hemolysis rate of 40% ~ 50% at 120 uM concentration, while the Kassinatuerin-3 still has no hemolysis at 160 uM, indicating that it has higher selectivity and lower toxicity to mammalian red blood cells.|||Horse erythrocytes (2.5% Hemolysis at 160 uM|||At a concentration of up to 160 μM, Kassinatuerin-3 did not show detectable hemolytic activity, with slight activity observed above this concentration. Kassinatuerin-1, which has a net charge of +2, has a MIC of 6.25 μM against Staphylococcus aureus, but induces 50% hemolysis at a concentration of 65 μM.|||Human RBCs: Kassinatuerin-3 produced no detectable hemolysis activity up to a concentration of 160 uM|||Kassinatuerin-3 produced no detectable hemolysis activity up to a concentration of 160 uM, above which there was slight activity (Figure5a)."	"Wang H, He H, Chen X, Zhou M, Wei M, Xi X, Ma C, Du Q, Che T, Shaw C, Wang L. 2020 Biology (Basel) . 2020 Jul 2;9(7):E148. doi: 10.3390/biology9070148. PubMed|||Biology (Basel)
. 2020 Jul 2;9(7):148. doi: 10.3390/biology9070148.|||Biology (Basel)
. 2020 Jul 2;9(7):148. doi: 10.3390/biology9070148.|||32630734|||Biology (Basel) . 2020 Jul 2;9(7):E148. doi: 10.3390/biology9070148. PubMed|||32630734|||Biology (Basel)
. 2020 Jul 2;9(7):148. doi: 10.3390/biology9070148.|||Biology (Basel). 2020 Jul 2;9(7):148.|||Biology (Basel) . 2020 Jul 2;9(7):E148. doi: 10.3390/biology9070148. PubMed"	20	
FPDB00260	AP03217|||AP03217|||Phylloseptin-PBa2|||Phylloseptin-PBa2|||AP03217	FLSLLPHIASGIASLVSKF	Anti-S. aureus, activity value is MIC = 5 uM||Anti-C. albicans, activity value is MIC = 15 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 200 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 5 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 15 uM||Anti-Gram+||Antifungal||candidacidal||Hemolytic||Anticancer	Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America|||Phyllomedusa burmeisteri [Burmeister's leaf frog]|||Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America	N/A	Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America|||Hourse red blood cells(100% hemolysis at 2 uM)|||Hourse red blood cells(100% hemolysis at 2 uM)|||These three phylloseptins exhibited different degrees of hemo lytic activities against red blood cells. Nevertheless, Phylloseptin PBa3 showed a much weaker effect than Phylloseptin-PBa1 and-PBa2, the HC50 of Phylloseptin-PBa1,-PBa2 and-PBa3 were 18.6 uM, 15.82 uM and 53.98 uM, respectively (Fig. 4. C).	"Wu Y, Wang L, Zhou M, Chen T, Shaw C.2019 Biochem Biophys Res Commun. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. PubMed|||Biochem Biophys Res Commun
. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. Epub 2019 Jan 3.|||30612735|||30612735|||Biochem Biophys Res Commun
. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. Epub 2019 Jan 3.|||Biochem Biophys Res Commun. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. PubMed"	19	
FPDB00261	AP03216|||AP03216|||Phylloseptin-PBa1|||Phylloseptin-PBa1|||AP03216	FLSLIPHIASGIASLVKNF	Anti-S. aureus, activity value is MIC = 5 uM||Anti-C. albicans, activity value is MIC = 20 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 200 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 5 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 20 uM||Anti-Gram+||Antifungal||candidacidal||Hemolytic||Anticancer	Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America|||Phyllomedusa burmeisteri [Burmeister's leaf frog]|||Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America	N/A	Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America|||Hourse red blood cells(100% hemolysis at 2 uM)|||Hourse red blood cells(100% hemolysis at 2 uM)|||These three phylloseptins exhibited different degrees of hemo lytic activities against red blood cells. Nevertheless, Phylloseptin PBa3 showed a much weaker effect than Phylloseptin-PBa1 and-PBa2, the HC50 of Phylloseptin-PBa1,-PBa2 and-PBa3 were 18.6 uM, 15.82 uM and 53.98 uM, respectively (Fig. 4. C).	"Wu Y, Wang L, Zhou M, Chen T, Shaw C.2019 Biochem Biophys Res Commun. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. PubMed|||Biochem Biophys Res Commun
. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. Epub 2019 Jan 3.|||30612735|||30612735|||Biochem Biophys Res Commun
. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. Epub 2019 Jan 3.|||Biochem Biophys Res Commun. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. PubMed"	19	
FPDB00262	AP03190|||AP03190|||Figainin 2, Figainin-02|||Figainin 2, Figainin-02|||AP03190|||DRAMP31416|||AP03190|||Figainin 2, Figainin-02|||DRAMP31416	FLGAILKIGHALAKTVLPMVTNAFKPKQ	Anti-E. casseliflavus ATCC 700327, activity value is MIC = 4||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 16||Anti-DENV4, activity value is EC50 = 20.8 uM||Anti-and YFV, activity value is EC50 = 21.8 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 32 uM||Anti-Klebsiella pneumoniae ATCC 13883, activity value is MIC = 8 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 16 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 8 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 8 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 4 uM||Anti-Enterococcus casseliflavus ATCC 700327, activity value is MIC = 4 uM||Anti-Trypanosoma cruzi, activity value is IC50 = 6.32 uM||Anti-Mouse skin melanoma B16-F10, activity value is IC50 = 12.8 uM||Anti-Human breast adenocarcinoma MCF-7, activity value is IC50 = 15.3 uM||Antimicrobial||Antiviral||Anti-Gram+ & Gram-||Antiparasitic||Anticancer	skin secretion, the Chaco tree frog, Boana raniceps, South America|||Boana raniceps (Hypsiboas raniceps)|||Boana raniceps (Hypsiboas raniceps)|||skin secretion, the Chaco tree frog, Boana raniceps, South America|||skin secretion, the Chaco tree frog, Boana raniceps, South America|||Boana raniceps (Hypsiboas raniceps)	Helix	"23% of hemolysis at 32000000 uM and 9% at 16000000 uM|||skin secretion, the Chaco tree frog, Boana raniceps, South America||Figure 2 shows that the HC50 is 48.9 µM, and it promotes hemolysis at a moderate rate, with a hemolysis rate of 23% at 32 µM and 9% at 16 µM.|||Human erythrocytes (9% Hemolysis at 16 uM|||Human erythrocytes (9% Hemolysis at 16 uM|||Figure 2 shows that the HC50 is 48.9 µM, and it promotes hemolysis at a moderate rate, with a hemolysis rate of 23% at 32 µM and 9% at 16 µM.|||The document mentions hemolytic-related data of Figainin 2, as follows:

- Half-hemolytic concentration (HC₅₀): 48.9 µM, which can cause 50% hemolysis of human red blood cells at this concentration.

- Hemolysis rates at different concentrations:

- At 32 µM, the hemolysis rate is 23%;

- At 16 µM, the hemolysis rate is 9%.

Note: In the hemolysis experiment, hemolysis induced by 1% Triton X-100 was taken as the 100% hemolysis standard, while treatment with Tris-saline was used as the 0% hemolysis control.|||Human erythrocytes (9% Hemolysis at 16 uM"	"Santana CJC, Magalhães ACM, Prías-Márquez CA, et al. 2020 Biomolecules. 2020;10(5):E790. PubMed|||Biomolecules
. 2020 May 20;10(5):790. doi: 10.3390/biom10050790.|||32443921|||32443921|||Biomolecules
. 2020 May 20;10(5):790. doi: 10.3390/biom10050790.|||Biomolecules. 2020 May 20;10(5):790.|||Biomolecules. 2020;10(5):E790. PubMed|||https://pubmed.ncbi.nlm.nih.gov/32443921|||Biomolecules. 2020 May 20;10(5):790."	28	
FPDB00263	AP03165|||DRAMP29095	GIKEMLCNMACAQTVCKKSGGPLCDTCQAACKALG	Anti-C. glutamicum, activity value is MIC = 1.6 uM||Anti-B. subtilis, activity value is MIC = 1.6 uM||Anti-E. coli, activity value is MIC = 12.5 uM||Anti-A2058, activity value is MIC = 25 uM||Anti-Corynebacterium glutamicum ATCC 13032, activity value is MIC = 1.6 uM||Anti-Bacillus subtilis ATCC 23857, activity value is MIC = 1.6 uM||Anti-Staphylococcus aureus ATCC 9144, activity value is MIC > 100 uM||Anti-##Gram-negative bacteria:Escherichia coli ATCC 25922, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 25 uM||Anti-##Cancer:Human melanoma A2058, activity value is IC50 = 4.1 uM	Synoicum turgens	Helix||Alpha helix,random coil	Synoicum turgens|||No hemolysis information or data found in the reference(s) presented in this entry	"Hansen IKØ, Isaksson J, Poth AG, Hansen KO, Andersen AJ, Richard CSM, Blencke H-M, Stensvag K, Craik DJ, Haug T. 2020, Norway, Europe Mar Drugs. 2020;18(1):E51. PubMed|||Mar Drugs
. 2020 Jan 12;18(1):51. doi: 10.3390/md18010051.|||Mar Drugs. 2020 Jan 12;18(1):51.||Ref.31940927"	35	
FPDB00264	AP03164|||DRAMP29094	GPKTKAACKMACKLATCGKKPGGWKCKLCELGCDAV	Anti-28% Mox0) is active against C. glutamicum, activity value is MIC = 0.4 uM||Anti-B. subtilis, activity value is MIC = 0.4 uM||Anti-S. aureus, activity value is MIC = 6.3 uM||Anti-E. coli, activity value is MIC = 0.8 uM||Anti-A2058, activity value is MIC = 1.6 uM||Anti-Bacillus megaterium, activity value is MIC = 0.5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 1.5 ug/ml||Anti-Corynebacterium glutamicum, activity value is MIC = 1.5 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 23.3 ug/ml||Anti-##Gram-negative bacteria:Escherichia coli, activity value is MIC = 3 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 5.9 ug/ml||Anti-##Fungi: Rhodotorula sp, activity value is MIC = 23.2 ug/ml||Anti-Aurobasidium pollulans, activity value is MIC = 92.6 ug/ml||Anti-Candida albicans, activity value is MIC = 46.3 ug/ml	Synoicum turgens	Random coil	Synoicum turgens|||No hemolysis information or data found in the reference(s) presented in this entry	"Hansen IKØ, Isaksson J, Poth AG, Hansen KO, Andersen AJ, Richard CSM, Blencke H-M, Stensvag K, Craik DJ, Haug T. 2020, Norway, Europe Mar Drugs. 2020;18(1):E51. PubMed|||Mar Drugs
. 2020 Jan 12;18(1):51. doi: 10.3390/md18010051.|||Int J Mol Sci.2020 Jul 30;21(15):5460.##Mar Drugs. 2020 Jan 12;18(1):51.||Ref.32751755||Ref.31940927"	36	
FPDB00265	AP03133|||AP03133|||Dermaseptin-PT9|||Dermaseptin-PT9|||AP03133	GLWSKIKDAAKTAGKAALGFVNEMV	Anti-S. aureus NCTC 10788, activity value is MIC = 16 uM||Anti-MRSA NCTC 12493, activity value is MIC = 32 uM||Anti-E. faecalis NCTC 12697, activity value is MIC = 16 uM||Anti-E. coli NCTC 10418, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 16 uM||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 8 uM||Anti-and C. albicans NCYC 1467, activity value is MIC = 64 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Anti-C. albicans NCYC 1467, activity value is MIC = 64 uM	skin secretion, Phyllomedusa tarsius, Purchased in Peru, South America|||Phyllomedusa tarsius|||Phyllomedusa tarsius|||skin secretion, Phyllomedusa tarsius, Purchased in Peru, South America|||skin secretion, Phyllomedusa tarsius, Purchased in Peru, South America	Helix	skin secretion, Phyllomedusa tarsius, Purchased in Peru, South America|||Horse erythrocytes [HC50 = 210 uM]|||Horse erythrocytes [HC50 = 210 uM]	"Li M, Xi X, Ma C, Chen X, Zhou M, Burrows JF, Chen T, Wang L.2019 Biomolecules. 2019 Oct 18;9(10). pii: E628. doi: 10.3390/biom9100628. PubMed|||Biomolecules
. 2019 Oct 18;9(10):628. doi: 10.3390/biom9100628.|||Biomolecules
. 2019 Oct 18;9(10):628. doi: 10.3390/biom9100628.|||31635388|||Biomolecules. 2019 Oct 18;9(10). pii: E628. doi: 10.3390/biom9100628. PubMed|||31635388|||Biomolecules
. 2019 Oct 18;9(10):628. doi: 10.3390/biom9100628.|||Biomolecules. 2019 Oct 18;9(10). pii: E628. doi: 10.3390/biom9100628. PubMed"	25	
FPDB00266	AP03087|||AP03087|||Limnonectes fujianensis Brevinvin|||Limnonectes fujianensis Brevinvin|||AP03087	GLFSVVKGVLKGVGKNVSGSLLDQLKCKISGGC	Anti-S. aureus, activity value is MIC = 16 ug/ml||Anti-E. coli, activity value is MIC = 32 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 64 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||Anti-Candida albicans, activity value is MIC = 64 ug/ml||Anti-Gram+ & Gram-||candidacidal||Anticancer	the Fujian Large Headed Frog, Limnonectes fujianensi, China, Asia|||Limnonectes fujianensis [Fujian Frog]|||Limnonectes fujianensis [Fujian Frog]|||the Fujian Large Headed Frog, Limnonectes fujianensi, China, Asia|||the Fujian Large Headed Frog, Limnonectes fujianensi, China, Asia	Helix	LFB exhibited significantly high hemolytic activity at a concentration of 16 ug/ml and above (Figure 5C)|||the Fujian Large Headed Frog, Limnonectes fujianensi, China, Asia|||Human erythrocytes (100% hemolysis at 500 ug/ml)|||Human erythrocytes (100% hemolysis at 500 ug/ml)|||This assay demonstrated that LFB exhibited significantly high hemolytic activity at a concentration of 16 ug/ml and above (Figure 5C). Each assay was carried out over three individual experiments and the standard errors were typically <5% of the mean.	"Li B, Lyu P, Xie S, Qin H, Pu W, Xu H, Chen T, Shaw C, Ge L, Kwok HF.2019 Biomolecules. 2019 Jun 21;9(6). pii: E242. doi: 10.3390/biom9060242. PubMed|||Biomolecules
. 2019 Jun 21;9(6):242. doi: 10.3390/biom9060242.|||31234333|||31234333|||Biomolecules
. 2019 Jun 21;9(6):242. doi: 10.3390/biom9060242.|||Biomolecules. 2019 Jun 21;9(6). pii: E242. doi: 10.3390/biom9060242. PubMed"	33	
FPDB00267	AP03061	SPRVRRRYGRPFGGRPFVGGQFGGRPGCVCIRSPCPCANYG	Anti-Recombinant rSs-arasin showed antimicrobial activity against S. aureus, activity value is IC50 = 20 uM||Anti-P. aeruginosa, activity value is IC50 = 40 uM||Anti-and E. coli, activity value is IC50 = 20 uM||activity value is IC50 = 3.06 uM||activity value is IC50 = 2.9 uM	the Indian mud crab, Scylla serrata	Bridge	the Indian mud crab, Scylla serrata||Compared with the hemolytic activity of 0.1% Triton X-100, brevinin 1ULf at 32, 64, and 128 µg/ml induced 13.1%, 54.7%, and 90.1% hemolysis, respectively.	"Anju A, Smitha CK, Preetha K, Boobal R, Rosamma P.2019 Fish Shellfish Immunol. 2019 Mar 6. 88:352-358. doi: 10.1016/j.fsi.2019.03.007. PubMed|||Fish Shellfish Immunol
. 2019 May:88:352-358. doi: 10.1016/j.fsi.2019.03.007. Epub 2019 Mar 6."	41	
FPDB00268	AP03057|||AP03057|||PSPHa|||Phylloseptin-PHa|||PSPHa|||Phylloseptin-PHa|||DRAMP32063	FLSLIPAAISAVSALANHF	Anti-S. aureus or MRSA NCTC 12497, activity value is MIC = 32.97 uM||Anti-E.faecalis NCTC 12697, activity value is MIC = 263.78 uM||Anti-E.coli NCTC 10418, activity value is MIC > 263.78 uM||Anti-and C.albicans NCYC 1467, activity value is MIC = 131.89 uM||Anti-Gram+||Anti-MRSA||Antibiofilm||Anticancer||Anti-Staphylococcus aureus, activity value is MIC = 8 uM||activity value is MBC = 16 uM||Anti-Candida albicans, activity value is MIC = 32 uM||activity value is MBC = 32 uM||Anti-methicillin-resistant Staphylococcus aureus, activity value is MIC = 64 uM||activity value is MBC = 128 uM||Anti-S. aureus NCTC 10788, activity value is MIC = 8 ug/ml||Anti-MRSA NCTC 12493, activity value is MIC = 8 ug/ml||Anti-E. faecalis NCTC 12697, activity value is MIC = 32 ug/ml||Anti-E. coli NCTC 10418, activity value is MIC = 32 ug/ml||Anti-C. albicans NCYC 1, activity value is MIC = 4 ug/ml||Antimicrobial	skin secretions, Orange-legged Leaf Frog, Pithecopus hypochondrialis, South America|||Pithecopus hypochondrialis [orange-legged leaf frog]|||Phyllomedusa hypochondrialis [orange-legged leaf frog]|||Pithecopus hypochondrialis	Helix	"In this document, the key values related to the hemolytic activity of two novel antimicrobial peptides derived from the skin of two leaf frogs (Phyllomedusa tarsius and Phyllomedusa hypochondrialis), phylloseptin-PTa and phylloseptin-PHa, are presented. These were determined by horse red blood cell hemolysis assay (using 2% Triton X-100 as the 100% hemolysis positive control and PBS as the 0% hemolysis negative control):

Core Hemolytic Activity Results

- Test indicators: The hemolytic toxicity of the two peptides was evaluated based on the half-hemolysis concentration (HC_{50}, peptide concentration inducing 50% hemolysis of horse red blood cells) and the 10% hemolysis concentration (HC_{10}, peptide concentration inducing 10% hemolysis of horse red blood cells).

- Hemolytic values of each peptide:

- phylloseptin-PTa:
  - HC_{10} = 7.79 μM, HC_{50} = 22.8 μM;
  - At its antibacterial effective concentration (MIC against S. aureus = 4.14 μM), the hemolysis rate was only 4.42%, indicating low hemolytic toxicity.

- phylloseptin-PHa:
  - HC_{10} = 76.5 μM, HC_{50} = 109.5 μM;
  - At its antibacterial effective concentration (MIC against S. aureus = 32.97 μM), the hemolysis rate was only 2.52%, with hemolytic toxicity much lower than that of phylloseptin-PTa.|||skin secretions, Orange-legged Leaf Frog, Pithecopus hypochondrialis, South America|||horse erythrocytes (HC50 = 52.17 uM)|||Horse erythrocytes (HC50= 109.5 uM)|||The document clearly provides detailed hemolytic data for two types of antimicrobial peptides in leaf frogs (phylloseptin-PTa and phylloseptin-PHa), with the core information as follows: 
 
1. Key hemolytic markers (Tsushima erythrocytes)
 
The hemolytic properties of the two peptides were measured by hemolysis rates at half the hemolytic concentration (HC₅₀), 10% hemolytic concentration (HC₁₀), and minimum inhibitory concentration (MIC). Specific data are shown in Table 2: 
 
Peptide Name Hemolytic Rate at S. aureus MIC HC₁₀(uM) HC₅₀(uM) 
phylloseptin-PTa 4.42% 7.79 22.8 
phylloseptin-PHa 2.52% 76.5 109.5 
 
- HC₁₀: The concentration of peptides inducing 10% red blood cell hemolysis; the higher the value, the lower the hemolytic activity at lower concentrations; 
- HC₅₀: The concentration of peptides inducing 50% hemolysis of red blood cells; the higher the value, the lower the overall hemolysis; 
- Both have hemolytic rates below 5% at MIC concentrations targeting Staphylococcus aureus (S. aureus), with phylloseptin-PHa being only 2.52%, indicating lower hemolytic toxicity. 
 
2. Experimental Background and Safety Verification
 
- Experimental method: 4% red blood cell suspension was prepared from defibrotic horse blood and incubated with peptides of different concentrations (1~512 uM) at 37°C for 2 hours. The absorbance of the supernatant at 550 nm (reflecting hemoglobin release) was measured. The 2% Triton X-100 treatment group was used as the 100% hemolytic positive control and 1% DMSO/PBS as the solvent control. The hemolysis rate was calculated using formulas. 
- Security Comparison: 
1. The hemolytic properties of both peptides are significantly lower than those of most highly toxic antimicrobial peptides (for example, some frog-derived peptides have hemolytic rates exceeding 10% under MIC); 
2. Combined with treatment index (TI) analysis (Table 3), the ratio of HC₁₀ to MIC/MBEC (minimum biofilm clearance concentration) for inhibiting Gram-positive bacteria and clearing Staphylococcus aureus biofilms was greater than 1, indicating a low risk of hemolysis at effective antibacterial concentrations; 
3. Cytotoxicity tests on human microvascular endothelial cells (HMEC-1) showed that phylloseptin-PHa showed mild toxicity at test concentrations, while phylloseptin-PTa showed significant toxicity only at 100 uM, further confirming their safety against normal mammalian cells. 
 
In summary, both types of antimicrobial peptides in leaf frogs exhibit low hemolytic characteristics, with phylloseptin-PHa having lower hemolytic activity, providing important safety evidence for its use as an anti-infective drug candidate.|||horse erythrocytes (HC50 = 52.17 uM)|||Horse erythrocytes (HC50= 109.5 uM)|||Horse erythrocytes: 10% Hemolysis=76.5 uM; 50% Hemolysis=109.5 uM; 50% Hemolysis=52.17 uM"	"Liu J, Wu Q, Li L, Xi X, Wu D, Zhou M, Chen T, Shaw C, Wang L.2017 Molecules. 2017 Aug 29;22(9). pii: E1428. doi: 10.3390/molecules22091428. PubMed|||Molecules
. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428.|||Molecules
. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428.|||30774309|||28850103|||Molecules. 2017 Aug 29;22(9). pii: E1428. doi: 10.3390/molecules22091428. PubMed|||30774309|||28850103|||Molecules. 2017 Aug 29;22(9):1428."	19	
FPDB00269	AP03049|||VLL28|||AP03049	VLLVTLTRLHQRGVIYRKWRHFSGRKYR	activity value is MIC = 90||Anti-B. subtilis AZ54, activity value is MIC = 3 uM||Anti-E. coli DH5alpha, activity value is MIC = 1.5 uM||Anti-P. aeruginosa PAOI or PA14 or RP73, activity value is MIC = 3||Anti-C. parapsilosis 3 or 10, activity value is MIC = 25 uM||Anti-C. tropicalis 54 or 2, activity value is MIC = 12.5 uM||Anti-C. glabrata 28 or 34, activity value is MIC = 50 uM||Anti-and C. krusei, activity value is MIC = 25 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibiofilm||Anticancer||Anti-Candida albicans ATCC10231, activity value is MIC = 25 uM||Anti-Candida albicans 80, activity value is MIC = 25 uM||Anti-Candida albicans 81, activity value is MIC = 25 uM||Anti-C. parapsilosis 3, activity value is MIC = 25 uM||Anti-C. parapsilosis 10, activity value is MIC = 25 uM||Anti-C. tropicalis 54, activity value is MIC = 12.5 uM||Anti-C. tropicalis 2, activity value is MIC = 12.5 uM||Anti-C. glabrata 28, activity value is MIC = 50 uM||Anti-C. glabrata 34, activity value is MIC = 50 uM||Anti-C. krusei 1, activity value is MIC = 25 uM||Anti-C. krusei 14, activity value is MIC = 25 uM	Sulfolobus islandicus	Helix	Sulfolobus islandicus	"Notomista E, Falanga A, Fusco S, Pirone L, Zanfardino A, Galdiero S, Varcamonti M, Pedone E, Contursi P.2015 Microb Cell Fact. 2015 Sep 4;14:126. doi: 10.1186/s12934-015-0302-9. PubMed||this ref||Roscetto E et al. 2018|||Microb Cell Fact
. 2015 Sep 4:14:126. doi: 10.1186/s12934-015-0302-9.||this ref||Roscetto E et al. 2018|||Microb Cell Fact. 2015 Sep 4;14:126. doi: 10.1186/s12934-015-0302-9. PubMed|||30514888|||Microb Cell Fact
. 2015 Sep 4:14:126. doi: 10.1186/s12934-015-0302-9.||this ref||Roscetto E et al. 2018|||Microb Cell Fact. 2015 Sep 4;14:126. doi: 10.1186/s12934-015-0302-9. PubMed"	28	
FPDB00270	AP03041|||AP03041|||CAMPSQ12278|||DRAMP29104|||AP03041|||DRAMP29104	LNLKALLAVAKKIL	Anti-E. faecalis, activity value is MIC = 4||Anti-S. aureus or MRSA, activity value is MIC = 2||Anti-E. coli, activity value is MIC = 4||Anti-P. aeruginosa, activity value is MIC = 8||Anti-and C. albicans, activity value is MIC = 4||Anti-Gram+ B. cereus ATCC 11778, activity value is MIC = 4 uM||Anti-L. monocytogenes ATCC 15313, activity value is MIC = 8 uM||Anti-S. enterica ATCC 13076, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Antibiofilm||Anticancer||Anti-S.aureus NCTC 10788, activity value is MIC = 2 uM||Anti-E.coli NCTC 10418, activity value is MIC = 4 uM||Anti-C.albicans NCTC 1467, activity value is MIC = 4 uM||Anti-S.aureus MRSA ATCC 12493, activity value is MIC = 4 uM||Anti-P.aeruginosa ATCC 27853, activity value is MIC = 8 uM||Anti-E.faecalis NCTC 12697, activity value is MIC = 8 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 2 uM||activity value is MIC = 4||Anti-Escherichia coli NCTC 10418, activity value is MIC = 4 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 8 uM||Anti-Candida albicans NCTC 1467, activity value is MIC = 4 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4 uM||Anti-Bacillus subtilis ATCC 23857, activity value is MIC = 4 uM||activity value is MIC = 4 uM||activity value is MIC = 8 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 8 uM||activity value is MIC = 16 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 2 uM||activity value is MBC = 4 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MIC = 8 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MBC = 8 uM||Anti-##Gram-negative bacteria:Escherichia coli NCTC 10418, activity value is MIC = 4 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 16 uM||Anti-Candida albicans NCTC 1467, activity value is MBC = 4 uM||Anti-##Cancer:Human squamous lung carcinoma NCI-H157, activity value is IC50 = 13.57 uM||Anti-Human breast adenocarcinoma MDA-MB-435S, activity value is IC50 = 27.7 uM||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 6.29 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 36.65 uM||Anti-Human breast adenocarcinoma MCF-7, activity value is IC50 = 25.27 uM	venom, the European Hornet, Vespa crabro|||venom, the European Hornet, Vespa crabro, Europe (introuced to US)|||Vespa crabro [European hornet]|||Vespa crabro|||venom, the European Hornet, Vespa crabro, Europe (introuced to US)|||Vespa crabro|||venom, the European Hornet, Vespa crabro, Europe (introuced to US)	Helix||Alpha helix,random coil	"causing no hemolysis to human erythrocytes within 200 uM|||In this document, the key values related to hemolysis for mastoparan-C (MP-C) derived from European hornet (Vespa crabro) venom and its two modified analogs (cyclic cMP-C and TAT-conjugated tMP-C) are as follows, measured using a horse red blood cell hemolysis assay (with 1% Triton X-100 as the 100% hemolysis positive control and PBS as the 0% hemolysis negative control):

Core Hemolytic Activity Results

- Test Indicator: Hemolytic toxicity of the three peptides was evaluated using the half hemolysis concentration (HC_{50}, i.e., the peptide concentration inducing 50% hemolysis of horse red blood cells) as the core indicator.

- HC_{50} values of each peptide:

- MP-C (natural peptide): HC_{50}=40.11 μM, moderate hemolytic activity; its effective antibacterial concentration (MIC against sensitive bacteria = 2–8 μM) is much lower than HC_{50}, and its toxicity to normal cells (human microvascular endothelial cells HMEC-1) is relatively low (IC₅₀=57.15 μM), resulting in a high therapeutic index.

- cMP-C (cyclic modified peptide): HC_{50}=9.19 μM, hemolytic activity significantly increased (4.4 times that of the natural peptide), and its hemolytic concentration is lower than the antibacterial concentration for most cancer cells...|||venom, the European Hornet, Vespa crabro|||Horse RBCs (HC50 = 40.11 uM)|||[Ref.29904274]50% hemolysis against horse erythrocytes at 40.11 uM.##[Ref.33285267]10% hemolysis against mouse erythrocytes at 64 uM; 60% hemolysis against mouse erythrocytes at 256 uM.|||Similar results were obtained by Yoon et al. (antimicrobial activity against E.coli ATCC 11775 (MIC>1000 uM), S.aureus ATCC 12600 (MIC=500 uM), C.albicans ATCC 10231 (MIC=100 uM) and causing no hemolysis to human erythrocytes within 200 uM 25), although effective concentrations were up to two orders of magnitude higher than what we observed."	"Chen X, Zhang L, Wu Y, Wang L, Ma C, Xi X, Bininda-Emonds ORP, Shaw C, Chen T, Zhou M.2018 Int J Biol Sci. 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. PubMed||combined with new data from ref for AP4034|||Int J Biol Sci
. 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. eCollection 2018.|||Int J Biol Sci
. 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. eCollection 2018.||combined with new data from ref for AP4034|||29904274|||Int J Biol Sci. 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. PubMed|||Int J Biol Sci. 2018 Apr 25;14(6):599-607.||Ref.29904274||Ref.33285267|||Int J Biol Sci
. 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. eCollection 2018.||combined with new data from ref for AP4034|||Eur J Pharm Sci. 2021 Mar 1;158:105665.##Int J Biol Sci. 2018 Apr 25;14(6):599-607.||Ref.29904274||Ref.33285267|||Int J Biol Sci. 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. PubMed"	14	
FPDB00271	AP03040|||DRAMP32135	GIMDTVKNAAKNLAGQLLDKLKCSITAC	Anti-S. aureus NCTC 10788, activity value is MIC = 32 uM||Anti-MRSA ATCC 12493, activity value is MIC = 256 uM||Anti-E.fecalis NCTC 12697, activity value is MIC = 128 uM||Anti-and P.aeruginosa ATCC 27853, activity value is MIC > 512 uM||Antimicrobial||Anticancer	skin secretions, the pickerel frog, Rana palustris, North America|||skin secretions of the pickerel frog (Rana palustris)	Helix	skin secretions, the pickerel frog, Rana palustris, North America|||Horse erythrocytes: Low haemolytic activity	"Chen X, Zhang L, Ma C, Zhang Y, Xi X, Wang L, Zhou M, Burrows JF, Chen T.2018 Biosci Rep. 2018 Nov 9;38(6):BSR20180710. doi: 10.1042/BSR20180710. PubMed|||Biosci Rep
. 2018 Nov 9;38(6):BSR20180710. doi: 10.1042/BSR20180710. Print 2018 Dec 21.|||Biosci Rep. 2018 Nov 9;38(6):BSR20180710."	28	
FPDB00272	AP03039|||AP03039|||Dermaseptin-PS1, Dermaseptin cDNA|||Dermaseptin-PS1, Dermaseptin cDNA|||AP03039	ALWKTMLKKLGTVALHAGKAALGAVADTISQ	Anti-S. aureus, activity value is MIC = 10 uM||Anti-E. coli, activity value is MIC = 10 uM||Antibacterial||Antifungal||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 10 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 100 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 10 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 100 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 100 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 5.419 uM||Anti-Gram+ & Gram-||candidacidal||Anticancer	skin, the waxy monkey tree frog, Phyllomedusa sauvagei, South America|||Phyllomedusa sauvagii|||Phyllomedusa sauvagii|||skin, the waxy monkey tree frog, Phyllomedusa sauvagei, South America|||skin, the waxy monkey tree frog, Phyllomedusa sauvagei, South America	Helix	skin, the waxy monkey tree frog, Phyllomedusa sauvagei, South America|||Horse erythrocytes (<20% Hemolysis at 10 uM|||Horse erythrocytes (<20% Hemolysis at 10 uM	"Long Q, Li L, Wang H, Li M, Wang L, Zhou M, Su Q, Chen T, Wu Y.2018 J Cell Mol Med. 2019; 23 (10), 6797-6804. doi: 10.1111/jcmm.14032. PubMed|||J Invest Dermatol
. 2019 May;139(5):1135-1142. doi: 10.1016/j.jid.2018.11.004. Epub 2018 Nov 20.|||30461197|||30461197|||J Invest Dermatol
. 2019 May;139(5):1135-1142. doi: 10.1016/j.jid.2018.11.004. Epub 2018 Nov 20.|||J Cell Mol Med. 2019; 23 (10), 6797-6804. doi: 10.1111/jcmm.14032. PubMed"	31	
FPDB00273	AP03016|||AP03016|||Dermaseptin DRS-DU-1|||Dermaseptin DRS-DU-1|||AP03016	ALWKSLLKNVGKAAGKAALNAVTDMVNQ	Anti-S. aureus MRSA, activity value is MIC = 4 uM||Anti-P. aeruginosa, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anticancer||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 4 uM	Callimedusa (Phyllomedusa) duellmani, Peru, South America|||Phyllomedusa duellmani|||Phyllomedusa duellmani|||Callimedusa (Phyllomedusa) duellmani, Peru, South America	Helix	"50% hemolysis of the red bloods cells|||This document focuses on the study of novel dermaseptin antimicrobial peptides discovered from the secretions of two types of frog skin, involving multiple aspects such as peptide cloning, synthesis, antimicrobial activity, and hemolytic activity testing. Among these, hemolytic activity was tested using horse red blood cells, with 1% DMSO as the negative control and Triton X-100 as the positive control. The hemolysis rate and the half-maximal hemolytic concentration (HC_{50}) were calculated by measuring absorbance at 550 nm. The specific values are as follows:

Table

Peptide | Half-Maximal Hemolytic Concentration (μM) | Hemolytic Activity Analysis
--- | --- | ---
DRS-CA-1 | 114.7 | At MIC or MBC concentrations, there is no significant hemolytic activity against the tested microorganisms except for Enterococcus faecalis; compared to other peptides with high hemolytic activity, this peptide has a lower hemolysis rate at relatively low concentrations and causes minimal damage to red blood cells.
DRS-DU-1 | 216.6 | Has strong antimicrobial activity, with no significant hemolytic activity at MIC or MBC concentrations except against Enterococcus faecalis; higher than DRS-CA-1, indicating lower toxicity to red blood cells and causing less damage to normal cells while maintaining antimicrobial effects.
DP-1 |  | Has relatively low antimicrobial activity and almost no hemolytic activity; even at higher concentrations, it does not show significant hemolysis, making it safe for red blood cells, though its antimicrobial potency is weak.
DP-2 |  | Antimicrobial activity is restored, and its activity against Enterococcus faecalis is higher than that of natural peptides; shows no significant hemolytic activity, indicating a low risk of red blood cell damage while exerting antimicrobial effects, with potential application value.|||Callimedusa (Phyllomedusa) duellmani, Peru, South America||The MIC, MBC and HC50 values of all the peptides obtained from antimicrobial and hemolysis assays are summarized in Table 2. The two natural peptides, DRS-CA-1 and DRSDU-1, showed the same MIC values (4 uM) against S. aureus and E. coli and C. albicans. DRS-DU-1 was twofold more potent against MRSA, E. faecalis, K. pneumoniae and P. aeruginosa than DRS-CA-1. The MBC values of two natural peptides against seven tested microorganisms were two or four-fold higher than respective MICs. No obvious hemolysis activity was detected at the MIC or MBC concentrations except against E. faecalis. The two designed peptides also exhibited broad spectrum antimicrobial activities against the seven tested microorganisms, though the potency of DP-1 was much lower. However, the antimicrobial activities of DP-2 were restored comparing to DP-1. Additionally, the antimicrobial potency of DP-3 on E. faecalis was higher than the natural peptides.|||Horse erythrocytes (50% Hemolysis at 216.6 uM)|||Horse erythrocytes (50% Hemolysis at 216.6 uM)|||DRS-CA-1 and DRS-DU-1 exhibited strong antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi with no obvious hemolytic activity, and almost the same proportion of polar residues and nonpolar residues as well as the a-helical structure."	"Zhu H, Ding X, Li W, Lu T, Ma C, Xi X, Wang L, Zhou M, Burden R, Chen T.2018 PeerJ. 2018 Sep 19;6:e5635. doi: 10.7717/peerj.5635. PubMed|||PeerJ
. 2018 Sep 19:6:e5635. doi: 10.7717/peerj.5635. eCollection 2018.|||PeerJ
. 2018 Sep 19:6:e5635. doi: 10.7717/peerj.5635. eCollection 2018.|||30258724|||30258724|||PeerJ
. 2018 Sep 19:6:e5635. doi: 10.7717/peerj.5635. eCollection 2018.|||PeerJ. 2018 Sep 19;6:e5635. doi: 10.7717/peerj.5635. PubMed"	28	
FPDB00274	AP03008|||AP03008|||Dermaseptin-4|||Dermaseptin DPS3|||Dermaseptin DPS3|||AP03008|||DRAMP01676	ALWKDILKNAGKAALNEINQIVQ	Anti-E. coli NCTC 10418, activity value is MIC = 32 uM||Antibacterial||Antifungal||Anti-S. aureus NCTC 10788, activity value is MIC = 256 uM||Anti-C. albicans NCYC 1467, activity value is MIC = 64 uM||Antimicrobial||Anti-Gram+||Anti-Gram-||candidacidal||Anticancer	skin secretion, Phyllomedusa sauvagii, USA, North America|||Phyllomedusa tarsius [Brownbelly leaf frog]|||Phyllomedusa sauvagii [waxy monkey tree frog]|||Phyllomedusa sauvagii [waxy monkey tree frog]|||skin secretion, Phyllomedusa sauvagii, USA, North America|||Phyllomedusa tarsius (Brownbelly leaf frog)|||skin secretion, Phyllomedusa sauvagii, USA, North America	Helix	skin secretion, Phyllomedusa sauvagii, USA, North America||All three peptides exhibited some haemolytic activity against healthy red blood cells (Figure 5). However, both artificial analogues exhibited a greater effect than the parent peptide, with the L10, 11-DPS3 analogue showing marked haemolysis even at lower concentrations. The HC50s of DPS3, K5, 17-DPS3 and L10, 11-DPS3 are 138.1, 14.98 and 3.44, respectively.|||Horse blood cells (HC50s = 138.1 uM )|||Horse blood cells (HC50s = 138.1 uM )	"Tan Y, Chen X, Ma C, Xi X, Wang L, Zhou M, Burrows JF, Kwok HF, Chen T.2018 Toxins (Basel). 2018 Aug 7;10(8). 320. doi: 10.3390/toxins10080320. PubMed|||Toxins (Basel)
. 2018 Aug 7;10(8):320. doi: 10.3390/toxins10080320.|||30087268|||30087268|||Toxins (Basel)
. 2018 Aug 7;10(8):320. doi: 10.3390/toxins10080320.|||Submitted (AUG-2006) to UniProtKB.|||Toxins (Basel). 2018 Aug 7;10(8). 320. doi: 10.3390/toxins10080320. PubMed"	23	
FPDB00275	AP02980|||AP02980|||TAT-RasGAP317-326|||DRAMP35617	RRRQRRKKRGGGDTRLNTVWMW	Anti-This designed anticancer peptide also shows antimicorbial activity against E. coli, activity value is MIC = 11||Anti-A. baumannii, activity value is MIC = 2.9 uM||Anti-S. aureus, activity value is MIC = 46 uM||Anti-E. faecium, activity value is MIC = 23 uM||Anti-L. monocytogenes, activity value is MIC = 46 uM||Anti-S. maltophilia, activity value is MIC = 6 uM||Anti-S. pyogenes, activity value is MIC = 2.9 uM||Anti-S. typhimurium, activity value is MIC = 23 uM||Anti-and P. aeruginosa, activity value is MIC = 23||Antibacterial||Antibiofilm||Anti-Gram+ & Gram-||Anticancer||Antimicrobial	hybrid peptide, designed, man-made sequences|||Synthetic construct	N/A	"Maximum hemolysis (set at 100%) was triggered with 0.5% triton-X treatment of erythrocytes|||hybrid peptide, designed, man-made sequences||Hemolytic activity was measured as described in Ando et al. (2010). Briefly, blood (2 ml), derived from anonymous healthy human blood donors obtained through the Vaud blood transfusion service, were mixed with 2 ml PBS and centrifuged at 800000000 ug for 0.083333 h at 4◦C. Samples were washed three times with PBS and resuspended in 2 ml PBS and further diluted with 18 ml PBS. This erythrocyte solution was diluted 10 times with PBS before treatment with various amounts of TAT-RasGAP317−326 peptide. After 0.5 h incubation at 37◦C, samples were centrifuged at 800000000 ug for 0.083333 h at 4◦C and the absorbance at 540 nm of the supernatant was measured. As a positive control (100% lysis), erythrocytes (0.2 ml of the final dilution preparation) were treated with 0.5% Triton X-100.|||Acinetobacter baumannii ATCC 19606 (MIC=8 ug/ml), Pseudomonas aeruginosa PA14 (MIC=32 ug/ml), Staphylococcus aureus ATCC 29213 (MIC=128 ug/ml)|||The document explicitly provides specific hemolytic data for TAT-RasGAP₃₁₇₋₃₂₆, with the core information as follows:

Hemolytic values of TAT-RasGAP₃₁₇₋₃₂₆

In the section ""TAT-RasGAP₃₁₇₋₃₂₆ Neither Alters Mouse Health Nor Triggers Hemolysis"" and Figure 5C, it is clearly stated that:
TAT-RasGAP₃₁₇₋₃₂₆, even at the highest tested concentration (256 µg/ml, approximately 90 µM), still showed no hemolytic activity.

Key experimental background and rationale

Experimental method: Human red blood cells (from healthy anonymous donors) were co-incubated with varying concentrations of TAT-RasGAP₃₁₇₋₃₂₆ for 30 minutes (37°C). After centrifugation, the absorbance of the supernatant at 540 nm (reflecting hemoglobin release) was measured, with the 0.5% Triton X-100 treated group used as the 100% hemolysis positive control.
Result determination: Across the entire tested concentration range (including 256 µg/ml, which far exceeds the in vitro antibacterial effective concentration), the hemolysis rate induced by the peptide showed no difference from the negative control (untreated group), indicating a 0% hemolysis rate and proving that it has no cytotoxicity on human red blood cells.

In summary, TAT-RasGAP₃₁₇₋₃₂₆ maintains extremely low hemolytic activity even at high concentrations, which is an important safety feature as a potential antimicrobial agent, providing key safety evidence for subsequent clinical applications."	"Heulot M, Jacquier N, Aeby S, Le Roy D, Roger T, Trofimenko E, Barras D, Greub G, Widmann C. Front Microbiol. 2017 Jun 7;8:994. doi: 10.3389/fmicb.2017.00994. PubMed|||Front Microbiol
. 2017 Jun 7:8:994. doi: 10.3389/fmicb.2017.00994. eCollection 2017.|||33852935|||Front Microbiol. 2017 Jun 7;8:994. doi: 10.3389/fmicb.2017.00994. PubMed|||Front Microbiol. 2017 Jun 7;8:994."	22	
FPDB00276	AP02977|||AP02977|||Temporin-PE|||Temporin-PE|||AP02977|||DRAMP18658	FLPIVAKLLSGLL	Anti-S. aureus, activity value is MIC = 2 uM||Anti-MRSA, activity value is MIC = 4 uM||Anti-E. faecalis, activity value is MIC = 8 uM||Anti-and C. albicans, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anticancer||Anti-Staphylococcus aureus, activity value is MIC = 2 uM||Anti-Methicillin-resistant Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Enterococcus faecalis, activity value is MIC = 8 uM||Anti-Escherichia coli, activity value is MIC = 16 uM||Anti-Candida albicans, activity value is MIC = 4 uM||Anti-P. aeruginosa, activity value is MIC = 128 uM||Antibacterial||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 16 uM||Anti-##Fungus: Candida albicans, activity value is MIC = 4 uM||Anti-U251MG, activity value is IC50 = 25.13 uM||Anti-PC-3, activity value is IC50 = 38.56 uM||Anti-MDA-MB-435s, activity value is IC50 = 33.23 uM||Anti-HMEC-1, activity value is IC50 = 58.62 uM	skin secretions, Pelophylax kl. esculentus, Europe|||Pelophylax kl.esculentus [Edible frog]|||Pelophylax kl.esculentus [Edible frog]|||skin secretions, Pelophylax kl. esculentus, Europe|||Pelophylax kl.esculentus(Europe edible frog)|||skin secretions, Pelophylax kl. esculentus, Europe	Helix||Alpha helix	Temporin-PE, temporin-PEa and temporin-PEb exhibited different degrees of hemolysis on horse erythrocytes with HC50 of 39.64 uM, 531.7 uM and 44.64 uM, respectively.|||svgsqq05aqe3x4h6uske|||skin secretions, Pelophylax kl. esculentus, Europe|||The hemolysis and pain induction of SvcAMPs have been reported in previous literature, noting that some SvcAMPs exhibit hemolytic activity against mammalian blood cells (Corzo et al., 2001; Gao et al., 2009; Harrison et al., 2016). This activity has long been considered a defensive strategy to repel small mammals. To provide further evidence to support this speculation, we collected blood cells from three of the most common vertebrates that feed on scorpions (mice, lizards, and birds; Polis, 1990) to evaluate the hemolytic activity of crude venom from Mesobuthus martensii and individual SvcAMPs. As shown in Figure 7A, snake venom diluted with 0.9% sodium chloride caused 50% hemolysis of mouse and lizard blood cells, and 25.7 ± 1.7% hemolysis of bird blood cells (Figure 7A). For individual peptide components, at a peptide concentration of 3.125 μM, all SvcAMPs exhibited varying degrees of hemolysis against mouse blood cells, with MeuFSPL1 and marmelittin showing the strongest hemolytic effects, at 61 ± 2.5% and 66 ± 1.2%, respectively. At this concentration, bee venom could cause complete hemolysis. As the peptide concentration increased to 6.25 μM, hemolytic activity of most SvcAMPs exceeded 50%, while the hemolytic activity of MeuFSPL-1 and marmelittin increased to nearly 100%. When the peptide concentration reached 12.5 μM, almost all peptides caused complete hemolysis except Meucin-13. Meucin-13 required 25 μM to achieve the same effect.|||[Ref.29191658]HC50=39.64 uM against horse red blood cells|||TAT is an arginine-rich decapeptide derived from HIV-1, an ideal cell-penetration segment to transit drugs through cell membranes via membrane translocation and endocytosis, with no hemolytic effects, mild antibiotic activity and inhibits the growth of fungi with MICs ranging from 3 uM to 24 uM [35].	"Sang M, Wu Q, Xi X, Ma C, Wang L, Zhou M, Burrows JF, Chen T.2018 Biochem Biophys Res Commun. 2018 Jan 22;495(4):2539-2546. doi: 10.1016/j.bbrc.2017.11.173. PubMed|||Biochem Biophys Res Commun
. 2018 Jan 22;495(4):2539-2546. doi: 10.1016/j.bbrc.2017.11.173. Epub 2017 Nov 28.|||Biochem Biophys Res Commun
. 2018 Jan 22;495(4):2539-2546. doi: 10.1016/j.bbrc.2017.11.173. Epub 2017 Nov 28.|||29191658|||29191658|||Biochem Biophys Res Commun
. 2018 Jan 22;495(4):2539-2546. doi: 10.1016/j.bbrc.2017.11.173. Epub 2017 Nov 28.|||Biochem Biophys Res Commun. 2018 Jan 22;495(4):2539-2546.||Ref.29191658|||Biochem Biophys Res Commun. 2018 Jan 22;495(4):2539-2546. doi: 10.1016/j.bbrc.2017.11.173. PubMed"	13	
FPDB00277	AP02976|||DRAMP01295	NLVSALIEGRKYLKNVLKKLNRLKEKNKAKNSKENN	Anti-bacteria mainly Gram- E. coli, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa, activity value is MIC = 64 ug/ml||Antimicrobial||Anti-Gram-||Antifungal||candidacidal||Anticancer	Skin Secretion, Phyllomedusa hypochondrialis, South America|||Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)|||Skin Secretion, Phyllomedusa hypochondrialis, South America	N/A	Skin Secretion, Phyllomedusa hypochondrialis, South America	"Wu D, Gao Y, Tan Y, Liu Y, Wang L, Zhou M, Xi X, Ma C, Bininda-Emonds ORP, Chen T, Shaw C.2018 Front Microbiol. 2018 Mar 23;9:541. doi: 10.3389/fmicb.2018.00541. PubMed|||Front Microbiol
. 2018 Mar 23:9:541.doi: 10.3389/fmicb.2018.00541.eCollection 2018.|||Front Microbiol
. 2018 Mar 23:9:541. doi: 10.3389/fmicb.2018.00541. eCollection 2018.|||Thesis (2006), University of Ulster Coleraine, United Kingdom|||Front Microbiol. 2018 Mar 23;9:541. doi: 10.3389/fmicb.2018.00541. PubMed"	36	
FPDB00278	AP02926|||AP02926|||Bacteriocin TP|||DRAMP31985	ASVVNKLTGGVAGLLK	Anti-E. coli ATCC 25922, activity value is MIC = 2.5||Anti-A. hydrophila CGMCC1.1802, activity value is MIC = 5 uM||Anti-S. a Typhimurium CMCC 2212, activity value is MIC = 5||Anti-and S. Pullorum CMCC 519, activity value is MIC = 10||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.5 uM||Anti-Escherichia coli, activity value is MIC = 10 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 10||Anti-Staphylococcus aureus CMCC 26003, activity value is MIC = 10||Anti-Staphylococcus aureus, activity value is MIC = 20 uM||Anti-Aeromonas hydrophila CGMCC1.1802, activity value is MIC = 5 uM||Anti-Salmonella typhimurium CMCC 2212, activity value is MIC = 5||Anti-Listeria monocytogenes CMCC 53-5, activity value is MIC > 80 uM||Anti-Streptococcus pyogenes ATCC 19615, activity value is MIC = 20 uM||Anti-Pseudomonas aeruginosa CMCCB 10102, activity value is MIC = 10 uM||Anti-Pasteurella sp. CMCC 464, activity value is MIC = 20 uM||Anti-Glaesserella parasuis CMCC 3728, activity value is MIC = 10||Anti-Salmonella enterica subsp. enterica serovar Pullorum CMCC 519, activity value is MIC = 20 uM||Anti-Human gastric cancer MKN 45, activity value is IC50 = 4.686 uM||Anti-Human acute promyelocytic leukemia NB4, activity value is IC50 = 11.479 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC > 128 uM||Anti-Escherichia coli UB1005, activity value is MIC > 128 uM||Anti-Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028, activity value is MIC > 128 uM||Anti-Salmonella enterica subsp. enterica serovar Typhimurium C77-31, activity value is MIC > 128 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 128 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC > 128 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC > 128 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 128 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC > 128 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC > 128 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC > 128 uM||Antimicrobial||Anticancer	caecum-derived strain TS|||Bacillus subtilis	N/A	caecum-derived strain TS|||Mouse erythrocytes (<10% Hemolysis at 160 uM, Human erythrocytes (50% Hemolysis at >128 uM|||Mouse erythrocytes: <10% Hemolysis=160 uM; 10% Hemolysis=320 uM	"Xin H, Ji S, Peng J, Han P, An X, Wang S, Cao B.2017 Int J Antimicrob Agents. 2017 Apr;49(4):427-436. doi: 10.1016/j.ijantimicag.2016.12.012. PubMed|||Int J Antimicrob Agents
. 2017 Apr;49(4):427-436. doi: 10.1016/j.ijantimicag.2016.12.012. Epub 2017 Feb 27.|||28254375|||Int J Antimicrob Agents. 2017 Apr;49(4):427-436."	16	
FPDB00279	AP02924	ALWKEVLKNAGKAALNEINNLV	Anti-and C. albicans, activity value is MIC = 16||Anti-more effective against E. coli and C. albicans, activity value is MIC = 16 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibiofilm||Anticancer	orange-legged leaf frog, Pithecopus (Phyllomedusa) hypochondrialis, South America|||orange-legged leaf frog, Pithecopus (Phyllomedusa) hypochondrialis, South America	Helix	"orange-legged leaf frog, Pithecopus (Phyllomedusa) hypochondrialis, South America|||The document explicitly mentions hemolytic information related to Dermaseptin-PH. The core conclusion is that it exhibits low cytotoxicity (low hemolysis) to mammalian red blood cells (horse red blood cells) within the effective antibacterial concentration range (16-64 µM), but does not provide specific hemolysis rate values.

Key experimental background and details:

1. Experimental subjects: A 4% (v/v) red blood cell suspension prepared from defibrinated horse blood.
2. Experimental method: Red blood cells were incubated with different concentrations (1-512 µM) of Dermaseptin-PH at 37 °C for 2 hours. Hemolysis was assessed by measuring absorbance at 570 nm; the 1% (v/v) Triton X-100 treatment group served as the positive control (complete hemolysis), while the phosphate-buffered saline (PBS) treatment group served as the negative control (no hemolysis).
3. Core results: Within the key concentration range where Dermaseptin-PH exhibits antibacterial activity (16-64 µM, corresponding to the minimum inhibitory concentration [MIC] and minimum bactericidal concentration [MBC] for Escherichia coli, Staphylococcus aureus, Candida albicans, etc.), no significant hemolysis was observed, confirming its low toxicity to red blood cells and good safety profile.

The document does not provide specific hemolysis percentage data at different concentrations, only qualitatively describing 'low cytotoxicity' and 'no obvious hemolysis,' and indicating its hemolytic characteristics through experimental observations (absorbance close to that of the negative control)."	"Huang L, Chen D, Wang L, Lin C, Ma C, Xi X, Chen T, Shaw C, Zhou M.2017 Molecules. 2017 Oct 24;22(10). pii: E1805. doi: 10.3390/molecules22101805. PubMed|||Molecules
. 2017 Oct 24;22(10):1805.doi: 10.3390/molecules22101805.|||Molecules. 2017 Oct 24;22(10). pii: E1805. doi: 10.3390/molecules22101805. PubMed|||Molecules
. 2017 Oct 24;22(10):1805. doi: 10.3390/molecules22101805.|||Molecules. 2017 Oct 24;22(10). pii: E1805. doi: 10.3390/molecules22101805. PubMed"	22	
FPDB00280	AP02921|||Bombinin H-BO1|||Bombinin H-BO1|||AP02921|||DRAMP32118	IIGPVLGLVGKALGGLL	Anti-Weakly active against C. albicans, activity value is MIC = 160 uM||Anti-E. coli, activity value is MIC > 161.1 uM||Anti-S. aureus, activity value is MIC > 161.1 uM||Anti-C. albicans, activity value is MIC > 161.1 uM||Antimicrobial||Anticancer||Antifungal||candidacidal	skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia|||Bombina orientalis [Oriental fire-bellied toad]|||skin secretion of Oriental fire-bellied toad, Bombina orientalis|||skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia	N/A	It caused only 2.89% hemolysis of the red cells at a concentration of 26.3 uM and 38.05% hemolysis at 52.5 uM.|||Human Red cells: caused 42.03% hemolysis of the red cells at a concentration of 40.3 uM while reaching 100% hemolysis at 161.1 uM|||Besides, Bombinin BO1 exhibited moderate hemolytic effect on human red blood cells. It caused only 2.89% hemolysis of the red cells at a concentration of 26.3 uM and 38.05% hemolysis at 52.5 uM. In contrast, Bombinin H-BO1 showed weak antibacterial action against C. albicans (161.1 uM for both MIC and MBC), and less effect on E. coli and S. aureus, whereas this peptide caused 42.03% hemolysis of the red cells at a concentration of 40.3 uM while reaching 100% hemolysis at 161.1 uM.	"Peng X, Zhou C, Hou X, Liu Y, Wang Z, Peng X, Zhang Z, Wang R, Kong D.2017 Amino Acids. 2017 Nov 2. doi: 10.1007/s00726-017-2509-z. PubMed|||29098406|||29098406|||Amino Acids
. 2018 Feb;50(2):241-253. doi: 10.1007/s00726-017-2509-z. Epub 2017 Nov 2.|||Amino Acids. 2018 Feb;50(2):241-253|||Amino Acids. 2017 Nov 2. doi: 10.1007/s00726-017-2509-z. PubMed"	17	
FPDB00281	AP02920|||AP02920|||Bombinin-BO1|||Bombinin-BO1|||AP02920|||DRAMP32116	GIGSAILSAGKSIIKGLAKGLAEHF	Anti-E. coli, activity value is MIC = 26 uM||Anti-S. aureus, activity value is MIC = 26 uM||Anti-C. albicans, activity value is MIC = 52 uM||Anti-E. coli, activity value is MIC = 26.3 uM||Anti-S. aureus, activity value is MIC = 26.3 uM||Anti-C. albicans, activity value is MIC = 52.5 uM||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal	skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia|||Bombina orientalis [Oriental fire-bellied toad]|||Bombina orientalis [Oriental fire-bellied toad]|||skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia|||Bombina orientalis|||skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia	N/A	"It caused only 2.89% hemolysis of the red cells at a concentration of 26.3 uM and 38.05% hemolysis at 52.5 uM.|||skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia||Besides, Bombinin-
BO1 exhibited moderate hemolytic effect on human red
blood cells. It caused only 2.89% hemolysis of the red
cells at a concentration of 26.3 uM and 38.05% hemolysis
at 52.5 uM. In contrast, Bombinin H-BO1 showed weak
antibacterial action against C. albicans (161.1 uM for both
MIC and MBC), and less effect on E. coli and S. aureus,
whereas this peptide caused 42.03% hemolysis of the red
cells at a concentration of 40.3 uM while reaching 100%
hemolysis at 161.1 uM.|||Human erythrocytes: 2.89% Hemolysis=26.3 uM; Human erythrocytes=38.05% Hemolysis=52.5 uM|||Besides, Bombinin BO1 exhibited moderate hemolytic effect on human red blood cells. It caused only 2.89% hemolysis of the red cells at a concentration of 26.3 uM and 38.05% hemolysis at 52.5 uM. In contrast, Bombinin H-BO1 showed weak antibacterial action against C. albicans (161.1 uM for both MIC and MBC), and less effect on E. coli and S. aureus, whereas this peptide caused 42.03% hemolysis of the red cells at a concentration of 40.3 uM while reaching 100% hemolysis at 161.1 uM."	"Peng X, Zhou C, Hou X, Liu Y, Wang Z, Peng X, Zhang Z, Wang R, Kong D.2017 Amino Acids. 2017 Nov 2. doi: 10.1007/s00726-017-2509-z. PubMed|||Amino Acids
. 2018 Feb;50(2):241-253. doi: 10.1007/s00726-017-2509-z. Epub 2017 Nov 2.|||29098406|||29098406|||Amino Acids
. 2018 Feb;50(2):241-253. doi: 10.1007/s00726-017-2509-z. Epub 2017 Nov 2.|||Amino Acids. 2018 Feb;50(2):241-253|||Amino Acids. 2017 Nov 2. doi: 10.1007/s00726-017-2509-z. PubMed"	25	
FPDB00282	AP02850|||AP02850|||Laterosporulin 10	ACVNQCPDAIDRFIVKDKGCHGVEKKYYKQVYVACMNGQHLYCRTEWGGPCQL	Anti-microtitre plate Alamar blue assay: Active against microbial pathhogens such as M. tuberculosis strain H37Rv, activity value is LD50 = 0.5 uM||Anti-Mycobacterium tuberculosis H37Rv, activity value is MIC = 50||Anti-Staphylococcus aureus MTCC 1430, activity value is MIC = 50||Anti-Bacillus subtilis MTCC 121, activity value is MIC = 50||Anti-Escherichia coli MTCC 1610, activity value is MIC = 100 uM||Anti-Mycobacterium smegmatis mc2-155, activity value is MIC = 50||Anti-Mycobacterium tuberculosis H37Rv, activity value is MIC = 16 uM||Anti-Staphylococcus aureus MTCC 1430, activity value is MBC = 8 uM	Brevibacillus sp. strain SKDU10|||Brevibacillus sp. SKDU10	Bridge	Laterosporulin10 did not exhibit hemolytic activity at concentrations up to 40 μM, and the hemolysis rate was less than 20% at 100 μM.|||Brevibacillus sp. strain SKDU10|||Rabbit erythrocytes ( at NA , Rabbit erythrocytes (<20% Hemolysis at 100 uM	"Baindara P, Singh N, Ranjan M, Nallabelli N, Chaudhry V, Pathania GL, Sharma N, Kumar A, Patil PB, Korpole S.2016 Microbiology. 2016 Aug;162(8):1286-99. doi: 10.1099/mic.0.000316. PubMed|||2016 Aug;162(8):1286-1299. doi: 10.1099/mic.0.000316. Epub 2016 Jun 7.|||Biochem Biophys Res Commun
. 2016 Sep 16;478(2):924-8. doi: 10.1016/j.bbrc.2016.08.052. Epub 2016 Aug 9.|||27267959"	53	
FPDB00283	AP02823	CHTNGGYCVRAICPPSARRPGSCFPEKNPCCKYM	PGN-activated PMC-derived mBD-2 significantly killed S. aureus||and mBD-2-neutralizing antibodies blunted this antimicrobial activity. Updated 7/2021; 11/2023	Mus musculus	Bridge	Mus musculus	"Jia HP, Wowk SA, Schutte BC, Lee SK, Vivado A, Tack BF, Bevins CL, McCray PB Jr.2000 J Biol Chem. 2000 Oct 27;275(43):33314-20. PubMed|||J Biol Chem
. 2000 Oct 27;275(43):33314-20. doi: 10.1074/jbc.M006603200."	34	
FPDB00284	AP02746|||AP02746|||Saha-CATH6|||DRAMP18428|||Saha-CATH6|||AP02746|||DRAMP18428	KRIRFFERIRDRLRDLGNRIKNRIRDFFS	Anti-Gram+ & Gram-||Antifungal||Anticancer||Anti-E. coli ATCC 25922, activity value is MIC > 64 ug/ml||Anti-E.coli, activity value is MIC > 64 ug/ml||Anti-S.aureusATCC 29213, activity value is MIC > 64 ug/ml||Anti-S. aureus— Methicillin resistant S. aureus, activity value is MIC > 64 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC > 64 ug/ml||Anti-P. aeruginosa*, activity value is MIC > 64 ug/ml||Anti-E. faecalis ATCC 29212, activity value is MIC > 64 ug/ml||Anti-E. faecalis, activity value is MIC > 64 ug/ml||Anti-Vancomycin resistant E. faecalis, activity value is MIC = 64 ug/ml||Anti-S. pneumoniae ATCC 49619, activity value is MIC = 64 ug/ml||Anti-S. pyogenes ATCC 19615, activity value is MIC = 64 ug/ml||Anti-S. agalactiae ATCC 12386, activity value is MIC = 64 ug/ml||Anti-S. agalactiae, activity value is MIC > 64 ug/ml||Anti-S. mutans, activity value is MIC > 64 ug/ml||Anti-S. oralis/mitis group, activity value is MIC = 64 ug/ml||Anti-S. dysgalactiae subs. equisimilis, activity value is MIC > 64 ug/ml||Anti-S. anginosus, activity value is MIC = 64 ug/ml||Anti-S. salivarius, activity value is MIC > 64 ug/ml||Anti-S. lutetiensis, activity value is MIC > 64 ug/ml||Anti-S. equi*, activity value is MIC > 64 ug/ml||Anti-K. pneumoniae*, activity value is MIC > 64 ug/ml||Anti-N. asteroides*, activity value is MIC > 64 ug/ml||Anti-L. monocytogenes*, activity value is MIC > 64 ug/ml||Anti-P. multocida, activity value is MIC > 64 ug/ml||Anti-C. parapsilosis ATCC 22019, activity value is MIC > 64 ug/ml||Anti-C. krusei ATCC 6258, activity value is MIC = 64 ug/ml||Anti-C. albicans, activity value is MIC > 64 ug/ml||Anti-C. glabrata, activity value is MIC > 64 ug/ml||Anti-C.neoforms, activity value is MIC = 64 ug/ml||Anti-C. gattii, activity value is MIC = 64 ug/ml||Antimicrobial||Antibacterial||No MICs found in DRAMP database	Tasmanian devil, Sarcophilus harrisii|||Sarcophilus harrisii [Tasmanian Devil]|||Tasmanian devil, Sarcophilus harrisii|||Sarcophilus harrisii [Tasmanian Devil]	N/A	"Tasmanian devil, Sarcophilus harrisii|||Human erythrocytes (<26% hemolysis at 500 ug/ml)|||Saha-CATH1: The hemolysis rate was below 7% at all tested concentrations (0.95~500 µg/ml), showing no significant hemolysis.

• Saha-CATH2: The hemolysis rate was significantly higher than the negative control only at 500 µg/ml, but still below 7%, indicating very weak hemolysis.

• Saha-CATH3: The hemolysis rate was significantly higher than the negative control at 250 µg/ml and 500 µg/ml, but both were below 7%, indicating very weak hemolysis.

• Saha-CATH4: The hemolysis rate was significantly higher than the negative control at 125~500 µg/ml, but all were below 7%, indicating very weak hemolysis.

• Saha-CATH5: The hemolysis rate was below 15% at 31.25~125 µg/ml; not clearly specified at 250 µg/ml; and reached 37% at 500 µg/ml (strongest hemolysis).

• Saha-CATH6: The hemolysis rate was below 15% at 31.25~125 µg/ml; below 26% at 250 µg/ml; and below 26% at 500 µg/ml, indicating moderate hemolysis.|||Human erythrocytes (<26% hemolysis at 500 ug/ml)"	27725697|||Sci Rep. 2016 Oct 11;6:35019|||27725697	29	
FPDB00285	AP02745|||AP02745|||Saha-CATH5|||DRAMP18429|||Saha-CATH5|||AP02745|||DRAMP31957|||DRAMP18429	KRIGLIRLIGKILRGLRRLG	Anti-Gram+ & Gram-||Antifungal||Anti-MRSA||Anticancer||Anti-E. coli ATCC 25922, activity value is MIC = 32 ug/ml||Anti-E.col, activity value is MIC = 32 ug/ml||Anti-Methicillin resistant S. aureus, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC > 64 ug/ml||Anti-P. aeruginosa*, activity value is MIC = 64 ug/ml||Anti-E. faecalis ATCC 29212, activity value is MIC > 64 ug/ml||Anti-E. faecalis, activity value is MIC > 64 ug/ml||Anti-Vancomycin resistant E. faecalis, activity value is MIC = 32 ug/ml||Anti-S. pneumoniae ATCC 49619, activity value is MIC = 64 ug/ml||Anti-S. pyogenes ATCC 19615, activity value is MIC = 32 ug/ml||Anti-S. agalactiae ATCC 12386, activity value is MIC = 64 ug/ml||Anti-S. agalactiae, activity value is MIC = 64 ug/ml||Anti-S. mutans, activity value is MIC > 64 ug/ml||Anti-S. oralis/mitis group, activity value is MIC = 64 ug/ml||Anti-S. dysgalactiae subs. equisimilis, activity value is MIC > 64 ug/ml||Anti-S. anginosus, activity value is MIC = 32 ug/ml||Anti-S. salivarius, activity value is MIC > 64 ug/ml||Anti-S. lutetiensis, activity value is MIC > 64 ug/ml||Anti-S. equi*, activity value is MIC = 64 ug/ml||Anti-K. pneumoniae*, activity value is MIC > 64 ug/ml||Anti-N. asteroides*, activity value is MIC > 64 ug/ml||Anti-L. monocytogenes*, activity value is MIC > 64 ug/ml||Anti-P. multocida, activity value is MIC > 64 ug/ml||Anti-C. parapsilosis ATCC 22019, activity value is MIC > 64 ug/ml||Anti-C. krusei ATCC 6258, activity value is MIC = 64 ug||Anti-C. albicans, activity value is MIC > 64 ug/ml||Anti-C. glabrata, activity value is MIC > 64 ug/ml||Anti-C.neoforms, activity value is MIC = 32 ug/ml||Anti-C. gattii, activity value is MIC = 64 ug/ml||Anti-and C. neoformans, activity value is MIC = 32||Antimicrobial	Tasmanian devil, Sarcophilus harrisii|||o0eg1cdwhptqyewyewfa|||Sarcophilus harrisii [Tasmanian Devil]|||Sarcophilus harrisii|||Tasmanian devil, Sarcophilus harrisii	N/A	"In this document, the key values related to the hemolytic activity of six cathelicidin peptides (Saha-CATH1–6) from the Tasmanian devil (Sarcophilus harrisii) are as follows, all determined by a human red blood cell hemolysis assay (with 1% Triton X-100 serving as the 100% positive control and PBS as the 0% negative control):

1. Hemolytic activity of each peptide (test concentration range: 0.95–500 µg/mL)

-Saha-CATH1: At all tested concentrations, the hemolysis rate was **&lt;7%**, with no significant hemolytic activity, and the absorbance at each concentration showed no statistically significant difference from the negative control (P&gt;0.05).

-Saha-CATH2: At the highest concentration of 500 µg/mL only, the hemolysis rate was **&lt;7%**, but the absorbance differed significantly from that of the negative control (P&lt;0.05); at all other concentrations, the hemolysis rate was extremely low and showed no statistically significant difference.

-Saha-CATH3: At concentrations of 250 µg/mL and 500 µg/mL, the hemolysis rate was **&lt;7%**, and the absorbance differed significantly from that of the negative control (P&lt;0.05); no significant hemolysis was observed at concentrations below 250 µg/mL.

-Saha-CATH4: At concentrations of 125–500 µg/mL, the hemolysis rate was **&lt;7%**, and there was a statistically significant difference in absorbance compared with the negative control (P&lt;0.05); no significant hemolysis was observed at concentrations below 125 µg/mL.

-Saha-CATH5 exhibited the strongest hemolytic activity, with a hemolysis rate of 37% at a concentration of 500 µg/mL (P&lt;0.05); at concentrations of 31.25–125 µg/mL, the hemolysis rate was **&lt;15%** (P&lt;0.05); and no significant hemolysis was observed at concentrations below 31.25 µg/mL.

-Saha-CATH6: At concentrations of 250 µg/mL and 500 µg/mL, the hemolysis rates were **&lt;26% (P&lt;0.05); at 31.25–125 µg/mL, the hemolysis rate was &lt;15%** (P&lt;0.05); no significant hemolysis was observed at concentrations below 31.25 µg/mL.

2. Core Conclusion

-With the exception of Saha-CATH5 and Saha-CATH6, which exhibited moderate hemolytic activity at high concentrations (≥250 µg/mL), the remaining four peptides (Saha-CATH1–4) showed no significant hemolytic activity across the entire concentration range tested (hemolysis rate &lt;7%).

-The hemolytic concentrations of all peptides were significantly higher than their minimum inhibitory concentrations (MICs) against bacteria; for example, the MIC of Saha-CATH5 against MRSA was 32 µg/mL, which is much lower than the 500 µg/mL corresponding to a 37% hemolysis rate. This indicates that these peptides exhibit low toxicity to human red blood cells while exerting their antibacterial activity.|||Tasmanian devil, Sarcophilus harrisii|||Human erythrocytes (37% hemolysis at 500 ug/ml)|||Saha-CATH1: The hemolysis rate was below 7% at all tested concentrations (0.95~500 µg/ml), showing no significant hemolysis.

• Saha-CATH2: The hemolysis rate was significantly higher than the negative control only at 500 µg/ml, but still below 7%, indicating very weak hemolysis.

• Saha-CATH3: The hemolysis rate was significantly higher than the negative control at 250 µg/ml and 500 µg/ml, but both were below 7%, indicating very weak hemolysis.

• Saha-CATH4: The hemolysis rate was significantly higher than the negative control at 125~500 µg/ml, but all were below 7%, indicating very weak hemolysis.

• Saha-CATH5: The hemolysis rate was below 15% at 31.25~125 µg/ml; not clearly specified at 250 µg/ml; and reached 37% at 500 µg/ml (strongest hemolysis).

• Saha-CATH6: The hemolysis rate was below 15% at 31.25~125 µg/ml; below 26% at 250 µg/ml; and below 26% at 500 µg/ml, indicating moderate hemolysis.|||Human erythrocytes (37% hemolysis at 500 ug/ml)|||Human erythrocytes:5% Hemolysis=1-31.25 ug/ml; 7% Hemolysis=62.5 ug/ml; 12% Hemolysis=125 ug/ml; 30% Hemolysis=250 ug/ml"	"Peel E, Cheng Y, Djordjevic JT, Fox S, Sorrell TC, Belov K.2016 Sci Rep. 2016 Oct 11;6:35019. PubMed|||Sci Rep
. 2016 Oct 11:6:35019. doi: 10.1038/srep35019.|||Sci Rep2016 Oct 11:6:35019. doi: 10.1038/srep35019.|||27725697|||Sci Rep. 2016 Oct 11;6:35019|||27725697|||Sci Rep
. 2016 Oct 11:6:35019. doi: 10.1038/srep35019.|||Sci Rep. 2016 Oct 11;6:35019."	20	
FPDB00286	AP02744|||Saha-CATH3|||DRAMP18430|||Saha-CATH3|||AP02744|||DRAMP18430	KRMGIFHLFWAGLRKLGNLIKNKIQQGIENFLG	Anti-C. neoformans, activity value is MIC = 16 ug/ml||Antibacterial||Antifungal	Tasmanian devil, Sarcophilus harrisii|||Sarcophilus harrisii [Tasmanian devil]|||Tasmanian devil, Sarcophilus harrisii|||Sarcophilus harrisii [Tasmanian devil]	N/A	"Human erythrocytes (non-hemolytic up to 500 ug/ml)|||Saha-CATH1: The hemolysis rate was below 7% at all tested concentrations (0.95~500 µg/ml), showing no significant hemolysis.

• Saha-CATH2: The hemolysis rate was significantly higher than the negative control only at 500 µg/ml, but still below 7%, indicating very weak hemolysis.

• Saha-CATH3: The hemolysis rate was significantly higher than the negative control at 250 µg/ml and 500 µg/ml, but both were below 7%, indicating very weak hemolysis.

• Saha-CATH4: The hemolysis rate was significantly higher than the negative control at 125~500 µg/ml, but all were below 7%, indicating very weak hemolysis.

• Saha-CATH5: The hemolysis rate was below 15% at 31.25~125 µg/ml; not clearly specified at 250 µg/ml; and reached 37% at 500 µg/ml (strongest hemolysis).

• Saha-CATH6: The hemolysis rate was below 15% at 31.25~125 µg/ml; below 26% at 250 µg/ml; and below 26% at 500 µg/ml, indicating moderate hemolysis.|||Human erythrocytes (Non - Hemolytic upto 500 ug/ml)"	"Peel E, Cheng Y, Djordjevic JT, Fox S, Sorrell TC, Belov K.2016 Sci Rep. 2016 Oct 11;6:35019. PubMed||Petrohilos et al., 2023|||27725697|||Sci Rep. 2016 Oct 11;6:35019|||27725697|||Sci Rep
. 2016 Oct 11:6:35019. doi: 10.1038/srep35019.||Petrohilos et al., 2023"	33	
FPDB00287	AP02730|||AP02730|||Smp43|||DRAMP18442|||AP02730|||DRAMP18442	GVWDWIKKTAGKIWNSEPVKALKSQALNAAKNFVAEKIGATPS	Anti-B. subtilis NCIMB 8024, activity value is MIC = 4 ug/ml||Anti-S. aureus SH100, activity value is MIC = 32||Anti-and C. albicans, activity value is MIC = 64||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Anticancer	venom, Scorpio maurus palmatus|||Scorpio maurus palmatus|||venom, Scorpio maurus palmatus|||venom, Scorpio maurus palmatus, Africa, Asia|||venom, Scorpio maurus palmatus, Africa, Asia	Helix	"venom, Scorpio maurus palmatus|||Sheep erythrocytes (<5% hemolysis at 512 ug/ml)|||Smp13: No antimicrobial activity, hemolytic data not explicitly mentioned, presumed to have no significant hemolysis.

• Smp24: At a concentration of 512 µg/ml, the hemolysis rate reached 89.6% ± 5.6%, indicating strong hemolysis.

• Smp24GVG (Pro-14 replaced by Gly-Val-Gly): At a concentration of 512 µg/ml, the hemolysis rate showed no significant difference compared to Smp24 (specific value not provided, only clearly stated as ""no obvious change"").

• Smp24T (C-terminal truncated by 4 residues): At a concentration of 512 µg/ml, the hemolysis rate decreased by 43% compared to Smp24, approximately 51.1% (89.6% × (1-43%)).

• Smp43: At a concentration of 512 µg/ml, the hemolysis rate was only 1.2% ± 0.5%, indicating extremely weak hemolysis."	"Harrison PL, Abdel-Rahman MA, Strong PN, Tawfik MM, Miller K.2016 Toxicon. 2016 Jul;117:30-6. PubMed|||Toxicon. 2016 Jul;117:30-6. PubMed|||27019370|||Toxicon. 2016 Jul;117:30-6.|||Toxicon
. 2016 Jul:117:30-6. doi: 10.1016/j.toxicon.2016.03.014. Epub 2016 Mar 24.|||Toxicon. 2016 Jul;117:30-6. PubMed"	43	
FPDB00288	AP02729|||AP02729|||Smp24|||DRAMP18443|||Smp24|||AP02729|||DRAMP18443	IWSFLIKAATKLLPSLFGGGKKDS	Anti-S. aureus SH100, activity value is MIC = 4||Anti-E. coli JM109, activity value is MIC = 64 ug/ml||Anti-and C. albicans, activity value is MIC = 32 ug/ml||Antibacterial||Antifungal||Anti-B. subtilis NCIMB 8024, activity value is MIC = 4 ug/ml||Anti-S. epidermidis sp, activity value is MIC = 8 ug/ml||Anti-S. aureus SH100, activity value is MIC = 8 ug/ml||Anti-K. pneumoniae NCTC 13439, activity value is MIC = 128 ug/ml||Anti-P.aeruginosa, activity value is MIC = 256 ug/ml||Anti-C. albicans, activity value is MIC = 32 ug/ml||Anti-Gram+ & Gram-||candidacidal||Anticancer	venom, Scorpio maurus palmatus|||Scorpio maurus palmatus|||venom, Scorpio maurus palmatus|||Scorpio maurus palmatus|||venom, Scorpio maurus palmatus, Africa, Asia|||venom, Scorpio maurus palmatus, Africa, Asia	Helix	"venom, Scorpio maurus palmatus|||Sheep erythrocytes (90% hemolysis at 512 ug/ml)|||Smp13: No antimicrobial activity, hemolytic data not explicitly mentioned, presumed to have no significant hemolysis.

• Smp24: At a concentration of 512 µg/ml, the hemolysis rate reached 89.6% ± 5.6%, indicating strong hemolysis.

• Smp24GVG (Pro-14 replaced by Gly-Val-Gly): At a concentration of 512 µg/ml, the hemolysis rate showed no significant difference compared to Smp24 (specific value not provided, only clearly stated as ""no obvious change"").

• Smp24T (C-terminal truncated by 4 residues): At a concentration of 512 µg/ml, the hemolysis rate decreased by 43% compared to Smp24, approximately 51.1% (89.6% × (1-43%)).

• Smp43: At a concentration of 512 µg/ml, the hemolysis rate was only 1.2% ± 0.5%, indicating extremely weak hemolysis.|||Sheep erythrocytes (90% hemolysis at 512 ug/ml)"	"Harrison PL, Abdel-Rahman MA, Strong PN, Tawfik MM, Miller K.2016 Toxicon. 2016 Jul;117:30-6. PubMed|||Toxicon. 2016 Jul;117:30-6. PubMed|||27019370|||Toxicon. 2016 Jul;117:30-6.|||27019370|||Toxicon
. 2016 Jul:117:30-6. doi: 10.1016/j.toxicon.2016.03.014. Epub 2016 Mar 24.|||Toxicon. 2016 Jul;117:30-6. PubMed"	24	
FPDB00289	AP02720	GFGSKPIDSFGLSWL	Anticancer	a Marine Streptomyces species	N/A	N/A	Um S, Kim YJ, Kwon H, Wen H, Kim SH, Kwon HC, Park S, Shin J, Oh DC.2013 J Nat Prod. 2013 May 24;76(5):873-9. PubMed	15	
FPDB00290	AP02719|||AP02719|||Chaxapeptin|||DRAMP18198	GFGSKPLDSFGLNFF	Anti-S. aureus and B. subtilis, activity value is MIC = 30||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 30||Anti-Bacillus subtilis NCTC 2116, activity value is MIC = 30||Antimicrobial||Antibacterial||Anti-Gram+||Anti-cancer	Streptomyces leeuwenhoekii Strain C58; extremophile|||Synthetic construct|||Streptomyces leeuwenhoekii Strain C58	Beta	Streptomyces leeuwenhoekii Strain C58; extremophile	Elsayed SS, Trusch F, Deng H, Raab A, Prokes I, Busarakam K, Asenjo JA, Andrews BA, van West P, Bull AT, Goodfellow M, Yi Y, Ebel R, Jaspars M, Rateb ME. 2015 J Org Chem. 2015 Oct 16;80(20):10252-60. PubMed|||J Org Chem. 2015 Oct 16;80(20):10252-60. PubMed|||26402731|||J Org Chem.80(20):10252-60(2015)	15	
FPDB00291	AP02691|||AP02691|||RP9	RGSALTHLP	Anti-Gram-negative V. cholerae and Gram-positive B. pumilus, activity value is MIC = 61.2 uM||B. pumilus TISTR 905||B. subtilis ATCC 6633||S. aureus ATCC 1466||S. epidermidis (clinical isolate)||V. cholerae (clinical isolate)||S. typhi ATCC 5784||E. coli 0157:H7 and P. aeruginosa (clinical isolate)	leukocyte extract, Crocodylus siamensis|||Synthetic construct	N/A	RP9 revealed the hemolytic effect on hRBCs around 3.3 ± 0.5 % at the MICs (61.2 lM) and 5.7 ± 0.2 % at the 29 MICs (122.4 lM)|||leukocyte extract, Crocodylus siamensis||Melittin lysed 99% ofrat red blood cells at a con-centration of25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep-tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 andContig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra-tion (200 ug/ml). Nevertheless, the hemolytic activities ofthe peptides ISGCock_Contig13_4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, andISGCock_Contig15_1337–2 were relatively low compared to that of melittin at a concentration of101 ug/ml.|||3.3% at MIC(61.2 uM)	Theansungnoen T, Maijaroen S, Jangpromma N, Yaraksa N1, Daduang S, Temsiripong T, Daduang J, Klaynongsruang S. 2016 Protein J. 2016 Jun;35(3):202-11. PubMed|||Protein J. 2016 Jun;35(3):202-11. PubMed	9	
FPDB00292	AP02670|||AP02670|||XLAsp-P1	DEDDD	Anti-Gram+ bacteria S. aureus ATC29213, activity value is MIC = 10 ug/ml||Anti-S. sciuri, activity value is MIC = 50 ug/ml||Anti-R. nasimurium, activity value is MIC = 10 ug/ml||Anti-A. viridans, activity value is MIC = 20 ug/ml||Anti-E. coli ATC25922 or O111, activity value is MIC = 50 ug/ml||Anti-K. pneumoniae, activity value is MIC = 50 ug/ml||Anti-and A. bacillus, activity value is MIC = 50 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 10 ug/ml||Anti-Staphylococcus sciuri, activity value is MIC = 50 ug/ml||Anti-Rothia nasimurium, activity value is MIC = 10 ug/ml||Anti-Aerococcus viridans, activity value is MIC = 20 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 50 ug/ml||Anti-Escherichia coli O111, activity value is MIC = 50 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 50 ug/ml	skin, African clawed frog, Xenopus laevis, Africa|||Synthetic construct	N/A	skin, African clawed frog, Xenopus laevis, Africa|||Rabbit erythrocytes (6% Hemolysis at 64 ug/ml	Li S, Hao L, Bao W, Zhang P, Su D, Cheng Y, Nie L, Wang G, Hou F, Yang Y.2016 Arch Microbiol. 2016 Jul;198(5):473-82. PubMed|||Arch Microbiol. 2016 Jul;198(5):473-82. PubMed	5	
FPDB00293	AP02661|||DRAMP31897	GTSCGETCVLLPCLSSVLGCTCQNKRCYKD	Anticancer||Antimicrobial	Hedyotis diffusa	Bridge	N/A	Hu E, Wang D, Chen J, Tao X. 2015 Int J Clin Exp Med. 2015 Mar 15;8(3):4059-65. PubMed|||Int J Clin Exp Med. 2015 Mar 15;8(3):4059-65.	30	
FPDB00294	AP02660|||DRAMP31896	GAVPCGETCVYLPCITPDIGCSCQNKVCYRD	Anticancer||Antimicrobial	Hedyotis diffusa	Bridge	N/A	Hu E, Wang D, Chen J, Tao X. 2015 Int J Clin Exp Med. 2015 Mar 15;8(3):4059-65. PubMed|||Int J Clin Exp Med. 2015 Mar 15;8(3):4059-65.	31	
FPDB00295	AP02659|||DRAMP31895	GAFLKCGESCVYLPCLTTVVGCSCQNSVCYRD	Anticancer||Antimicrobial	Hedyotis diffusa	Bridge	N/A	Hu E, Wang D, Chen J, Tao X. 2015 Int J Clin Exp Med. 2015 Mar 15;8(3):4059-65. PubMed|||Int J Clin Exp Med. 2015 Mar 15;8(3):4059-65.	32	
FPDB00296	AP02657	GLPLCGETCVGGTCNTPGCSCGWPVCVRN	Anticancer	Viola ignobilis	Bridge	N/A	Esmaeili MA, Abagheri-Mahabadi N, Hashempour H, Farhadpour M, Gruber CW, Ghassempour A.2016 Fitoterapia. 2016 Jan 2;109:162-168. PubMed	29	
FPDB00297	AP02544|||DRAMP35529	FCTCNVKGFNAKNKRGIIYP	Anticancer||Antimicrobial	centipede, Scolopendra subspinipes mutilans, Asia	N/A	N/A	Lee JH, Kim IW, Kim SH, Kim MA, Yun EY, Nam SH, Ahn MY, Kang DC, Hwang JS. 2015 J Microbiol Biotechnol. 2015 Aug;25(8):1275-80. PubMed|||J Microbiol Biotechnol. 2015 Aug;25(8):1275-80.	20	
FPDB00298	AP02531|||AP02531|||Stigmurin|||DRAMP20933|||DRAMP21024|||Stigmurin|||AP02531|||DRAMP20933|||DRAMP21024	FFSLIPSLVGGLISAFK	Anti-S. aureus ATCC 29213 or MRSA ATCC 33591, activity value is MIC = 8.68||Anti-S. epidermidis ATCC 122225, activity value is MIC = 9.38 uM||Anti-E.faecalis ATCC 4028, activity value is MIC > 150 uM||Anti-E.coli ATCC 25922, activity value is MIC > 139 uM||Anti-E.cloacae ATCC 13047, activity value is MIC > 150 uM||Anti-P.aeruginosa ATCC 27853, activity value is MIC > 150 uM||Anti-s C. albicans ATCC 90028, activity value is MIC = 34.75 uM||Anti-C. krusei ATCC 6258, activity value is MIC = 69.5||Anti-and C. glabrata ATCC 90030, activity value is MIC = 69.5||Anti-Gram+||Antifungal||candidacidal||Antioxidant||Anti-MRSA||Wound healing||Anticancer||Anti-Staphylococcus aureus, activity value is MIC = 9.4 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 9.4 uM||Anti-Candida albicans, activity value is MIC = 37.5 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 9.38 uM||Anti-Staphylococcus epidermidis ATCC 122225, activity value is MIC = 9.38 uM||Anti-s: Candida albicans ATCC 90028, activity value is MIC = 37.5 uM||Anti-HeLa cell line, activity value is IC50 = 7.98 uM||Anti-Enterococcus faecalis, activity value is MIC > 150 uM||Anti-Pseudomonas aeruginosa, activity value is MIC > 150 uM||Anti-Escherichia coli, activity value is MIC > 150 uM||Anti-Enterobacter cloacae, activity value is MIC > 150 uM||Anti-Candida glabrata, activity value is MIC > 150 uM||Anti-Candida krusei, activity value is MIC > 150 uM||Anti-##yeasts: Candida albicans ATCC 90028, activity value is MIC = 37.5 uM||Anti-##HeLa cell line, activity value is IC50 = 7.98 uM||Anti-##Gram-negative bacteria : Pseudomonas aeruginosa, activity value is MIC > 150 uM||Anti-##Fungi : Candida albicans, activity value is MIC = 37.5 uM	venom gland, Tityus stigmurus|||venom gland, Tityus stigmurus, Brazil, South America|||Tityus stigmurus [Brazilian scorpion]|||Tityus stigmurus|||Scorpion Tityus stigmurus|||venom gland, Tityus stigmurus, Brazil, South America|||Tityus stigmurus|||Scorpion Tityus stigmurus|||venom gland, Tityus stigmurus, Brazil, South America	Helix||Alpha helix	"Hemolysis Rate at the Highest Test Concentration

- Test concentration: 139.5 μM (the highest peptide concentration used in the experiment)

- Hemolysis rate: 22%

- Description: This value was determined by human red blood cell hemolysis assay. In the experiment, PBS (0% hemolysis, negative control) and distilled water (100% hemolysis, positive control) were used as references. Peptides were incubated with red blood cells at 37°C for 180 minutes, and the hemolysis percentage was calculated by measuring absorbance at 540 nm. The results indicate low hemolytic activity at this concentration.

2. Hemolysis Test Concentration Range

- Concentration range: 1.1–139.5 μM

- Result trend: At test concentrations below 139.5 μM, hemolysis rates were below 22%, and no significant hemolytic activity was observed (exact hemolysis rates at lower concentrations were not listed separately, but overall showed a concentration-dependent trend, with hemolysis reaching 22% only at the highest concentration).

3. Control Group Setup

- Negative control: PBS (pH 7.4), no hemolytic effect (0% hemolysis).

- Positive control: distilled water, inducing complete hemolysis (100% hemolysis), used for standardizing hemolysis rate calculations.|||venom gland, Tityus stigmurus||Stigmurin was found to possess low hemolytic activity (22 %)218at the highest concentration tested (139.5 uM), as shown in Figure 6|||hRBC, Non hemolytic|||-Detection object: healthy human O-type red blood cells, incubation conditions are 37 C, 1 hour, detection wavelength 540 nm.

-Control settings: 0% hemolysis (PBS only, no peptides/triton), 100% hemolysis (triton Triton-X).

-Natural peptide Stigmurin: very low hemolytic activity in the concentration range of 1.17-75 uM, with a hemolysis rate of only 3% at the highest concentration (75 uM).

-Analogs StigA6 and StigA16: hemolysis rate is about 30% at the highest concentration (75 uM); However, at low concentrations (corresponding to MIC and effective concentration) that exert antibacterial and antiproliferative activities, the hemolysis rate is less than 10% and the toxicity is weak.|||- Test subject: human red blood cells, incubation conditions were 37°C for 1 hour, detection wavelength 540 nm; negative control (0.9% saline) showed 0% hemolysis, positive control (1% Triton X-100) showed 100% hemolysis.  

- Natural peptide Stigmurin: at the highest concentration (150 µM), the hemolysis rate was only 5.8%, indicating extremely low hemolytic activity.  

- Analogues StigA25 and StigA31: hemolytic activity was concentration-dependent, with weak hemolysis at low concentrations (effective antimicrobial concentrations):  

  - At concentrations ≤ 9.4 µM, hemolysis rates were 18.5% for StigA25 and 11.2% for StigA31;  

  - Hemolysis slightly increased at higher concentrations, but overall remained low, and showed no significant hemolytic toxicity at their minimum inhibitory concentrations (MIC, 1.2–4.7 µM).  

- Key correlation: the analogues had increased net charge through lysine substitutions (StigA25: 5, StigA31: 7, native peptide: 2), which significantly enhanced antimicrobial activity without a substantial increase in hemolytic activity, indicating good safety.|||hRBC, Non hemolytic|||Hemolytic activity of StigMurin. Human red blood cells were incubated with a series of diluted StigMurin (1.1–139.5 μM) at 37 °C for 3 hours. PBS and distilled water were used as negative and positive lysis controls, respectively, and the activity was measured at 540 nm. The hemolysis rate was calculated as 679% relative to the positive control (100%).|||[Ref.29670004]Hemolysis 0% at 1.17 uM, hemolysis 1% at 2.34 uM, hemolysis 1% at 4.69 uM, hemolysis 0% at 9.38 uM, hemolysis 1% at 18.75 uM, hemolysis 1% at 37.5 uM, hemolysis 3% at 75 uM against human red blood cell|||[Ref.30709056] 7% hemolysis at 1.2 ug/ml , 4% hemolysis at 2.3 ug/ml , 2% hemolysis at 4.7 ug/ml , 0% hemolysis at 9.4 ug/ml , 3% hemolysis at 18.8 ug/ml , 2% hemolysis at 37.5 ug/ml , 3% hemolysis at 75 ug/ml , 5% hemolysis at 150 ug/ml against human red blood cells|||Stigmurin was found to possess low hemolytic activity (22 %) at the highest concentration tested (139.5 uM), as shown in Figure 6."	"Melo ET, Estrela AB, Santos EC, Machado PR, Farias KJ, Torres TM, de Carvalho E, Lima JP, Silva-Júnior AA, Barbosa EG, Fernandes-Pedrosa MF. 2015 Peptides. 2015 Jun;68:3-10. PubMed|||Peptides
. 2015 Jun:68:3-10. doi: 10.1016/j.peptides.2015.03.003. Epub 2015 Mar 22.|||Peptides. 2015 Jun;68:3-10. PubMed|||30709056|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||Int J Mol Sci. 2019 Jan 31;20(3). pii: E623. doi: 10.3390/ijms20030623.||Ref.30709056|||30709056|||Peptides
. 2015 Jun:68:3-10. doi: 10.1016/j.peptides.2015.03.003. Epub 2015 Mar 22.|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||Int J Mol Sci. 2019 Jan 31;20(3). pii: E623. doi: 10.3390/ijms20030623.||Ref.30709056|||Peptides. 2015 Jun;68:3-10. PubMed"	17	
FPDB00299	AP02495|||AP02495|||AaeAP2|||DRAMP21252|||AaeAP2|||AP02495|||DRAMP21252	FLFSLIPSAIAGLVSAIRN	Anti-C. albicans, activity value is MIC = 32 ug/ml||Anti-E.coli, activity value is MIC > 512 ug/ml||Anti-and S. aureus, activity value is MIC = 16 ug/ml||Animalia||Arachnida ; Androctonus aeneas||Anti-S. aureus, activity value is MIC = 16 ug/ml||Anti-C. albicans S, activity value is MIC = 32 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Antifungal||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||activity value is MBC = 16 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC > 512 ug/ml||Anti-##Fungi : Candida albicans, activity value is MIC = 32 ug/ml||activity value is MBC = 64 ug/ml||candidacidal||Anticancer	Venom, Androctonus aeneas, Africa|||Androctonus aeneas|||Androctonus aeneas|||Venom, Androctonus aeneas, Africa|||Venom, Androctonus aeneas, Africa	N/A	Venom, Androctonus aeneas, Africa|||S. aureus (MIC= 16 ug/ml), E. coli (MIC= >512 ug/ml), C. albicans S (MIC= 32 ug/ml)||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||[Ref.25626077] 100% hemolysis at 64 ug/ml against horse red blood cells	"Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C.2015 Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed|||Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed|||https://pubmed.ncbi.nlm.nih.gov/25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||25626077|||Toxins (Basel)
. 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.||Ref.25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed"	19	
FPDB00300	AP02494|||AP02494|||AaeAP1|||DRAMP21251|||AaeAP1|||AP02494|||DRAMP21251	FLFSLIPSVIAGLVSAIRN	Anti-C. albicans, activity value is MIC = 32 ug/ml||Anti-E.coli, activity value is MIC > 512 ug/ml||Anti-and S. aureus, activity value is MIC = 16 ug/ml||Antibacterial||Antifungal ; Androctonus aeneas||Anti-S. aureus, activity value is MIC = 16 ug/ml||Anti-C. albicans S, activity value is MIC = 32 ug/ml||Antimicrobial||Anti-Gram+||Antifungal||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||activity value is MBC = 32 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC > 512 ug/ml||Anti-##Fungi : Candida albicans, activity value is MIC = 32 ug/ml||activity value is MBC = 64 ug/ml||candidacidal||Anticancer	Venom, Androctonus aeneas, Africa|||Androctonus aeneas|||Androctonus aeneas|||Venom, Androctonus aeneas, Africa|||Venom, Androctonus aeneas, Africa	N/A	Venom, Androctonus aeneas, Africa|||S. aureus (MIC= 16 ug/ml), E. coli (MIC= >512 ug/ml), C. albicans S (MIC= 32 ug/ml)||Horse RBCs ( 100% hemolysis at 16 ug/ml)|||Horse RBCs ( 100% hemolysis at 16 ug/ml)|||Horse RBCs ( 100% hemolysis at 16 ug/ml)|||[Ref.25626077] 100% hemolysis at 16 ug/ml against horse red blood cells	"Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C.2015 Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed|||Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed|||https://pubmed.ncbi.nlm.nih.gov/25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||25626077|||Toxins (Basel)
. 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.||Ref.25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed"	19	
FPDB00301	AP02427|||AP02427|||CecropinXJ|||DRAMP18491	RWKIFKKIEKMGRNIRDGIVKAGPAIEVLGSAKAIGK	Anti-Gram-negative bacteria E. coli ATCC 25922, activity value is MIC = 1.43 uM||Anti-K. pneumoniae, activity value is MIC = 1.97 uM||Anti-S. flexneri, activity value is MIC = 3.21 uM||Anti-A. baumannii, activity value is MIC = 1.43 uM||Anti-S. sonnei, activity value is MIC = 2.89 uM||Anti-K. ozaenae, activity value is MIC = 4.62 uM||Anti-and Gram-positive bacteria S. aureus, activity value is MIC = 1.81 uM||Anti-D. ribution, activity value is MIC = 2.48 uM||Anti-S. epidermidis, activity value is MIC = 5.76 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 1.81	larvae, Bombyx mori|||Bombyx mori	N/A	larvae, Bombyx mori||The hemolysis rate is far below 10% at 200 uM.|||Human erythrocytes (35% hemolysis at 800 uM)|||No hemolysis information or data found in the reference(s) presented in this entry	Li JY, Zhang FC, Ma ZH 2004 Acta Entomol. Sin. 47 (2004) 407–411. Refer also to Xia L et al. (2013), PubMed||Xia L et al., 2014|||Acta Entomol. Sin. 47 (2004) 407–411. Refer also to Xia L et al. (2013), PubMed||Xia L et al., 2014|||23500722|||Protein Expr Purif. 2013 Jul;90(1):47-54.	37	
FPDB00302	AP02424|||Crotalicidin|||AP02424|||DRAMP31926|||DRAMP18193	KRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF	Anti-Gram+ E. faecalis ATCC 29212 and a clinical isolate, activity value is MIC = 7.7||Anti-S. aureus ATCC 29213 and a clinical isolate, activity value is MIC = 7.7 uM||Anti-S. pyogenes clinical isolate, activity value is MIC = 3.8 uM||Anti-P. aeruginosa ATCC 27853 and a clinical isolate, activity value is MIC = 0.24||Anti-K. pneumoniae clinical isolate, activity value is MIC = 1.9 uM||Anti-E. coli ATCC 25922 and a clinical isolate, activity value is MIC = 0.06||Anti-and A. baumannii clinical isolate, activity value is MIC = 3.8 uM||Anti-C. albicans ATCC90028, activity value is MIC = 20 ug/ml||Anti-C. albicans LAB, activity value is MIC = 0125||Anti-C. laurentii LAB, activity value is MIC = 0402||Anti-C. laurentii LAB, activity value is MIC = 0403||Anti-C. neoformans LAB, activity value is MIC = 0405||Anti-C. neoformans LAB, activity value is MIC = 0406||Antimicrobial||Anticancer||Anti-negative: E.coli ATCC 25922, activity value is MIC = 0.25 ug/ml||Anti-P.aeruginosa, activity value is MIC = 1 ug/ml||Anti-positive: E.faecalis, activity value is MIC = 32 ug/ml||Anti-S.aureus, activity value is MIC = 32 ug/ml	venom gland, South American pit vipers, Crotalus durissus terrificus|||Crotalus durissus terrificus|||venom gland, South American pit vipers, Crotalus durissus terrificus|||Rattlesnake Venom Cathelicidin|||Crotalus durissus terrificus (South American rattlesnake)	Helix||alpha helical	relatively less potent hemolysis|||venom gland, South American pit vipers, Crotalus durissus terrificus||The hemolysis rate of Crotalicidin reaches 10% at a concentration of 25 uM.|||OHCRAMP, an elastin-derived peptide from Asia, shows the lowest toxicity to red blood cells (10% hemolysis at 100 μM). Clocidin and Bactucin are slightly more toxic, reaching a 10% hemolysis rate at 25 μM and 12.5 μM, respectively. Nevertheless, extrapolating the data in Figure 5 suggests that at concentrations close to the millimolar range, all three peptides reach a 50% hemolysis rate, defining an appropriate (~2 log) selectivity window. For elapid-derived PT_CRAMP1, again compared with its Asian homolog, the previously observed poorer antibacterial spectrum is again accompanied by fairly strong hemolytic activity (10% at ~6.25 μM, 50% at only 50 μM), making it rather non-selective.|||Human erythrocytes: 7% and 33% hemolysis at 100 and 400 uM, respectively|||[Ref.25100358] Crotalicidin reached 10% hemolysis at 25 uM. Even so, extrapolation of existing data indicates that 50% hemolysis would be reached at near-millimolar values, which defines an adequate (~2 log) selectivity window.	"Falcao CB, de La Torre BG, Pérez-Peinado C, Barron AE, Andreu D, Rádis-Baptista G.2014 Amino Acids. 2014 Nov;46(11):2561-71. PubMed|||Amino Acids. 2014 Nov;46(11):2561-71. PubMed|||31626724|||Amino Acids
. 2014 Nov;46(11):2561-71. doi: 10.1007/s00726-014-1801-4. Epub 2014 Aug 7.|||J Med Chem. 2015 Nov 12;58(21):8553-63.|||Ref.25100358"	34	
FPDB00303	AP02412|||AP02412|||Brevinin 2R	KLKNFAKGVAQSLLNKASCKLSGQC	Active against S. aureus||M. luteus||Bacillus spKR-8104||E. coli||S. typhimurium||P. aeruginosa||K. pneumonidae and fungi||such as C. albicans and C. tropicalis.||Anti-Escherichia coli ATCC 25922, activity value is MBC = 6.25 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is LD50 = 10||Anti-Jurkat T-cell leukemia, activity value is LD50 = 20||Anti-Mouse fibrosarcoma L929, activity value is LD50 = 20||Anti-Mouse B-cell lymphoma BJAB, activity value is LD50 = 30||Anti-Escherichia coli ATCC 25922, activity value is MBC = 1.56 ug/ml||Anti-Leishmania major MRHO/IR/75/ER, activity value is IC50 = 40||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer	skin, Marsh frog, formerly Rana ridibunda , new name Pelophylax ridibunda, Europe|||Pelophylax ridibundus,Pelophylax esculentus|||skin, Marsh frog, formerly Rana ridibunda , new name Pelophylax ridibunda, Europe	N/A	skin, Marsh frog, formerly Rana ridibunda , new name Pelophylax ridibunda, Europe||Even at a concentration as high as 200 ug/ml, the hemolytic activity of Brevinin-2R against sheep red blood cells is only approximately 2.5%.|||Human erythrocytes (0% Hemolysis at 500 ug/ml, Human erythrocytes (50% Hemolysis at 250 ug/ml|||Low hemolytic activity of Brevinin 2R against sheep erythrocytes.Brevinin-2R at concentrations as high as 200 ug/ml resulted in only 2.5% hemolytic activity	"Ghavami S, Asoodeh A, Klonisch T, Halayko AJ, Kadkhoda K, Kroczak TJ, Gibson SB, Booy EP, Naderi-Manesh H, Los M.2008 J Cell Mol Med. 2008 Jun;12(3):1005-22. doi: 10.1111/j.1582-4934.2008.00129.x. PubMed|||J Cell Mol Med. 2008 Jun;12(3):1005-22. doi: 10.1111/j.1582-4934.2008.00129.x. PubMed|||30811391, 18494941|||J Cell Mol Med
. 2008 Jun;12(3):1005-22. doi: 10.1111/j.1582-4934.2008.00129.x.|||J Cell Mol Med. 2008 Jun;12(3):1005-22. doi: 10.1111/j.1582-4934.2008.00129.x. PubMed"	25	
FPDB00304	AP02378|||AP02378|||Surfactin|||Surfactin|||AP02378|||DRAMP33490|||DRAMP33491|||DRAMP33492|||DRAMP33493|||DRAMP33494|||DRAMP33495|||DRAMP33496|||DRAMP33497|||DRAMP33498|||CAMPSQ21265	ELLVDLL	Anti-B. cinerea and C. acutatum, activity value is MIC = 4||Anti-Rhizoctonia solani, activity value is MIC = 4 ug/ml||Anti-Colletotrichum acutatum, activity value is MIC = 8 ug/ml||Anti-Botrytis cinerea, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 16 ug/ml||Anti-Salmonella typhi, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 16 ug/ml||Anti-Human breast adenocarcinoma MDA-MB-231, activity value is IC50 = 14.9 ug/ml||Anti-Human colon adenocarcinoma HCT-15, activity value is IC50 = 11.4 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 10.8 ug/ml||Anti-Human lung adenocarcinoma NCI-H23, activity value is IC50 = 11.2 ug/ml||Anti-Human gastric cancer NUGC-3, activity value is IC50 = 11.8 ug/ml||Anti-Human renal adenocarcinoma ACHN, activity value is IC50 = 11.5 ug/ml||Anti-Rhizoctonia solani, activity value is MIC = 8 ug/ml||Anti-Botrytis cinerea, activity value is MIC = 8 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 32 ug/ml||Anti-Salmonella typhi, activity value is MIC = 32 ug/ml||Anti-Human breast adenocarcinoma MDA-MB-231, activity value is IC50 = 16.1 ug/ml||Anti-Human colon adenocarcinoma HCT-15, activity value is IC50 = 18.3 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 19.4 ug/ml||Anti-Human lung adenocarcinoma NCI-H23, activity value is IC50 = 11.7 ug/ml||Anti-Human gastric cancer NUGC-3, activity value is IC50 = 13.9 ug/ml||Anti-Human renal adenocarcinoma ACHN, activity value is IC50 = 18.4 ug/ml||Anti-Rhizoctonia solani, activity value is MIC = 32 ug/ml||Anti-Colletotrichum acutatum, activity value is MIC = 16 ug/ml||Anti-Botrytis cinerea, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 64 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 64 ug/ml||Anti-Human breast adenocarcinoma MDA-MB-231, activity value is IC50 = 11.2 ug/ml||Anti-Human colon adenocarcinoma HCT-15, activity value is IC50 = 23.2 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 11.7 ug/ml||Anti-Human lung adenocarcinoma NCI-H23, activity value is IC50 = 10.9 ug/ml||Anti-Human gastric cancer NUGC-3, activity value is IC50 = 10.5 ug/ml||Anti-Human renal adenocarcinoma ACHN, activity value is IC50 = 12.3 ug/ml||Anti-Mycoplasmopsis pulmonis MpUR1.1, activity value is MIC = 25 uM||Anti-Mycoplasmopsis pulmonis MpUR1.1, activity value is MBC = 100 uM||Anti-Microsporum canis, activity value is EC50 = 80 ug/ml||Anti-Venturia inaequalis S755, activity value is IC50 = 5.984 ug/ml||Anti-Venturia inaequalis Rs552, activity value is IC50 > 100 ug/ml||Anti-Carnobacterium divergens NCFB 2763, activity value is MIC > 1000 ug/ml||Anti-Brochothrix thermosphacta NCDO 1676, activity value is MIC > 1000 ug/ml||Anti-Candida krusei ATCC 6258, activity value is MIC > 256 ug/ml||Anti-Zygosaccharomyces bailii NCYC 464, activity value is MIC > 256 ug/ml||Anti-Debaryomyces hansenii NCYC 102, activity value is MIC > 256 ug/ml||Anti-Rhizopus stolonifer IMI 017314, activity value is MIC > 64 ug/ml||Anti-Paecilomyces variotii, activity value is MIC > 64 ug/ml||Anti-Byssochlamys fulva IMI 040021, activity value is MIC > 64 ug/ml||Anti-Human colon adenocarcinoma Caco-2, activity value is IC50 = 200 ug/ml||Antimicrobial||Anticancer||Antibacterial||Antiviral||Antifungal	Bacillus subtilis	N/A	Bacillus subtilis|||, Pig erythrocytes (50% Hemolysis at 45.9+-0.9 ug/ml, Intestinal Porcine Epithelial Cells IPEC-J2 (50% Cell death at 100 ug/ml, Pig kidney epithelial cells PK15 (50% Cytotoxicity at 32.87 ug/ml, Chicken Embryonic Fibroblasts (CEF) (50% Cytotoxicity at 89.16 uM, Vero cells (IC50 at 200 ug/ml|||, Pig erythrocytes (50% Hemolysis at 45.9+-0.9 ug/ml, Intestinal Porcine Epithelial Cells IPEC-J2 (50% Cell death at 100 ug/ml, Pig kidney epithelial cells PK15 (50% Cytotoxicity at 32.87 ug/ml, Chicken Embryonic Fibroblasts (CEF) (50% Cytotoxicity at 89.16 uM, Vero cells (IC50 at 200 ug/ml	"Tareq FS, Lee MA, Lee HS, Lee JS, Lee YJ, Shin HJ.2014 Mar Drugs. 2014 Jan 31;12(2):871-85. doi: 10.3390/md12020871.PubMed|||Mar Drugs. 2014 Jan 31;12(2):871-85. doi: 10.3390/md12020871.PubMed|||24492520, 30973929, 30068648, 17101680|||https://pubmed.ncbi.nlm.nih.gov/24492520,|||Mar Drugs
. 2014 Jan 31;12(2):871-85. doi: 10.3390/md12020871.|||Mar Drugs. 2014 Jan 31;12(2):871-85|||24492520"	7	
FPDB00305	AP02375|||AP02375|||Frenatin 2.2S|||DRAMP33487	GLVGTLLGHIGKAILS	Anti-strains S. aureus and S. epidermidis, activity value is MIC = 8||Anti-C. albicans, activity value is MIC = 62.5 uM||Anti-A. baumannii clinical isolates NM75, activity value is MIC = 62.5 uM||Anti-S. maltophilia clinical isolates B32/1 B32/4 U8908 B5/5 B6/2, activity value is MIC = 31||Anti-Erwinia amylovora, activity value is MIC = 25||Anti-Xanthomonas arboricola pv. Pruni, activity value is MIC = 62||Anti-Xanthonomas axonopodis pv. vesicatoria, activity value is MIC = 6.2||Anti-Xanthomonas fragariae, activity value is MIC = 25||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal	skin secretions, the Orinoco lime frog, Sphaenorhynchus lacteus, north central Guyana, South America|||Sphaenorhynchus lacteus|||skin secretions, the Orinoco lime frog, Sphaenorhynchus lacteus, north central Guyana, South America	N/A	50% hemolysis|||skin secretions, the Orinoco lime frog, Sphaenorhynchus lacteus, north central Guyana, South America||The LC₅₀ (uM) for human red blood cells is 169±7.|||Horse blood cells(84 ± 1.8% hemolysis at 375 uM)|||The LC50 value was calculated using commercially available software (SPSS version 17.0) and was taken as the mean concentration of peptide producing 50% hemolysis in three independent experiments.	"Conlon JM, Mechkarska M, Radosavljevic G, Attoub S, King JD, Lukic ML, McClean S.2014 Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed||Camó C et al. 2018|||Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed||Camó C et al. 2018|||30508634|||Peptides
. 2014 Jun:56:132-40. doi: 10.1016/j.peptides.2014.03.020. Epub 2014 Apr 4.||Camó C et al. 2018|||Peptides. 2014 Jun;56:132-40.|||Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed"	16	
FPDB00306	AP02374|||AP02374|||Frenatin 2.1S|||DRAMP33485|||DRAMP33486|||DRAMP33488|||DRAMP33489	GLVGTLLGHIGKAILG	Anti-strains S. aureus and S. epidermidis, activity value is MIC = 8||Anti-C. albicans, activity value is MIC = 62.5 uM||Anti-and NM75, activity value is MIC = 62.5 uM||Anti-S. maltophilia clinical isolates, activity value is MIC = 31||Anti-Erwinia amylovora, activity value is MIC = 25||Anti-Xanthonomas axonopodis pv. vesicatoria, activity value is MIC = 3.1||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal	skin secretions, the Orinoco lime frog, Sphaenorhynchus lacteus, north central Guyana, South America|||Sphaenorhynchus lacteus|||Guyana, South America	N/A	50% hemolysis|||skin secretions, the Orinoco lime frog, Sphaenorhynchus lacteus, north central Guyana, South America||The LC₅₀ (uM) for human red blood cells is 167±8.|||Horse blood cells(86 ± 2.4% hemolysis at 375 uM)|||The LC50 value was calculated using commercially available software (SPSS version 17.0) and was taken as the mean concentration of peptide producing 50% hemolysis in three independent experiments.	"Conlon JM, Mechkarska M, Radosavljevic G, Attoub S, King JD, Lukic ML, McClean S.2014 Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed||Camó C et al. 2018|||Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed||Camó C et al. 2018|||30508634|||Peptides
. 2014 Jun:56:132-40. doi: 10.1016/j.peptides.2014.03.020. Epub 2014 Apr 4.||Camó C et al. 2018|||Peptides. 2014 Jun;56:132-40.|||Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed"	16	
FPDB00307	AP02372|||DRAMP18309	WAIVLL	Weakly active against S. aureus. It induces apoptosis in tumor cells by a p53-independent pathway. Under annotation.||Antimicrobial||Antibacterial||Anti-Gram+	plant-associated Bacillus strain	N/A	plant-associated Bacillus strain	Niggemann J, Bozko P, Bruns N, Wodtke A, Gieseler MT, Thomas K, Jahns C, Nimtz M, Reupke I, Brüser T, Auling G, Malek N, Kalesse M.2014 Chembiochem. 2014 May 5;15(7):1021-9. doi: 10.1002/cbic.201300778.PubMed|||Chembiochem. 2014 May 5;15(7):1021-9. doi: 10.1002/cbic.201300778.PubMed|||Chembiochem. 2014 May 5;15(7):1021-9.	6	
FPDB00308	AP02340|||DRAMP31838	RLGDGCTR	Active against Cancer cells MDA-MB-231. I||Antimicrobial||Anticancer	somatic seedlings, Santalum album L.|||somatic seedlings of sandalwood	N/A	N/A	Abheepsa Mishraa, Samiran S. Gauria, Sourav K. Mukhopadhyaya, Soumya Chatterjeea, Shibendu S. Dasa, Santi M. Mandalb, Satyahari Dey Peptides. 2014 Feb 3. (online)|||Peptides. 2014 Apr;54:148-58.	8	
FPDB00309	AP02332|||DRAMP35180	CETPSKHFNGLCIRSSNCASVCHGEHFTDGRCQGVRRRCMCLKPC	Active against S. aureus and E. coli. It inhibits breast cancer cells MCF-7 as well  .||Antimicrobial||Anticancer	Avocado Fruit, Persea americana var. drymifolia|||Persea americana	Bridge	Avocado Fruit, Persea americana var. drymifolia	Guzmán-Rodríguez JJ, López-Gómez R, Suárez-Rodríguez LM, Salgado-Garciglia R, Rodríguez-Zapata LC, Ochoa-Zarzosa A, López-Meza JE.2013 Biomed Res Int. 2013;2013:986273. PubMed; Gene Bank||Guzmán-Rodríguez JJ et al., 2016|||Biomed Res Int. 2013;2013:986273. PubMed; Gene Bank||Guzmán-Rodríguez JJ et al., 2016|||Biomed Res Int. 2013;2013:986273.	45	
FPDB00310	AP02329	SKWQHQQDSCRKQLQGVNLTPCEKHIMEKIQGRGDDDDDDDDD	Also showed anti-oxidant and anti-inflammatory activity  .	Glycine max	N/A	N/A	Galvez AF, de Lumen BO.1999 Nat Biotechnol. 1999 May;17(5):495-500. PubMed. Precursor sequence GenBank: ACE36683.1||Ren et al., 2018	43	
FPDB00311	AP02328|||DRAMP33200	GSVIKCGESCLLGKCYTPGCTCSRPICKKD	Anti-Human non-small lung cancer cells A549 and E. coli, activity value is MIC = 0.6 uM||Antimicrobial||Anticancer	Clitoria ternatea	N/A	Clitoria ternatea	Sen Z, Zhan XK, Jing J, Yi Z, Wanqi Z.2013 Oncol Lett. 2013 Feb;5(2):641-644. PubMed.|||Oncol Lett. 2013 Feb;5(2):641-644. PubMed.|||Oncol Lett. 2013 Feb;5(2):641-644.	30	
FPDB00312	AP02327|||DRAMP33199	GIPCGESCVYIPCTVTALLGCSCKDKVCYKN	Active against Human non-small lung cancer cells A549.||Antimicrobial||Anticancer	Clitoria ternatea	N/A	N/A	Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP.2011 J Biol Chem. 2011 Jul 8;286(27):24275-87. PubMed.|||Oncol Lett. 2013 Feb;5(2):641-644.	31	
FPDB00313	AP02326|||AP02326|||Cter B	GVPCAESCVWIPCTVTALLGCSCKDKVCYLN	Anti-MIC against E.coli, activity value is MIC > 160 uM||Anti-Gram-||Anticancer||Antibacterial	Clitoria ternatea	N/A	Clitoria ternatea	Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP.2011 J Biol Chem. 2011 Jul 8;286(27):24275-87. PubMed.||Strömstedt AA et al., 2017|||J Biol Chem. 2011 Jul 8;286(27):24275-87. PubMed.|||28669767	31	
FPDB00314	AP02325|||AP02325|||Cter R	GIPCGESCVFIPCTVTALLGCSCKDKVCYKN	Anti-E. coli, activity value is MIC = 40 uM||Anti-P. aeruginosa, activity value is MIC = 0.625 uM||Anti-S.aureus, activity value is MIC > 160 uM||Antibacterial	Clitoria ternatea	N/A	Clitoria ternatea	Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP.2011 J Biol Chem. 2011 Jul 8;286(27):24275-87. PubMed.|||J Biol Chem. 2011 Jul 8;286(27):24275-87. PubMed.|||28669767	31	
FPDB00315	AP02319|||AP02319|||Pseudhymenochirin-2Pa|||Pseudhymenochirin-2Pa|||AP02319|||DRAMP31856	GIFPIFAKLLGKVIKVASSLISKGRTE	Anti-S. aureus, activity value is MIC = 5||Anti-S. epidermidis, activity value is MIC = 2.5||Anti-E. faecalis, activity value is MIC = 20 um||Anti-and C. albicans, activity value is MIC = 80 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 20 uM||Anti-Escherichia coli ATCC 25726, activity value is MIC > 40 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5 uM||Anti-Escherichia coli ATCC 25726, activity value is MIC > 80 uM||Anti-Staphylococcus aureus 127/08, activity value is MIC = 5 uM||Anti-Staphylococcus aureus 145/08, activity value is MIC = 10 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 5 uM||Anti-Staphylococcus epidermidis RP62A/1, activity value is MIC = 2.5 uM||Anti-Staphylococcus epidermidis T6/19, activity value is MIC = 5 uM||Anti-Staphylococcus epidermidis T37/8, activity value is MIC = 10 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 20 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC > 80 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 80 uM||Anti-Acinetobacter baumannii NM8, activity value is MIC = 20 uM||Anti-Acinetobacter baumannii NM35, activity value is MIC = 10 uM||Anti-Stenotrophomonas maltophilia B32/1, activity value is MIC = 10 uM||Anti-Stenotrophomonas maltophilia B5/5, activity value is MIC = 40 uM||Anti-Stenotrophomonas maltophilia U8908, activity value is MIC = 20 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 80 uM||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-diabetes||Hemolytic	skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Pseudhymenochirus merlini|||Pseudhymenochirus merlini|||skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||skin secretions of the frog Pseudhymenochirus merlini (Pipidae)	Helix	skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Human umbilical vein endothelial cells HUVEC (50% Cell death at 68+-2 uM, Human erythrocytes (50% Hemolysis at 6.2+-1 uM, Mouse erythrocytes (50% Hemolysis at 7+-2 uM|||Human umbilical vein endothelial cells HUVEC (50% Cell death at 68+-2 uM, Human erythrocytes (50% Hemolysis at 6.2+-1 uM, Mouse erythrocytes (50% Hemolysis at 7+-2 uM|||Human erythrocytes: LC50=6.2±1 uM|||highly hemolytic (LC50 6.2 uM)	"Conlon JM, Prajeep M, Mechkarska M, Coquet L, Leprince J, Jouenne T, Vaudry H, King JD.2013 Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med|||24212286, 25447194, 26606380|||24212286, 25447194, 26606380|||Comp Biochem Physiol Part D Genomics Proteomics
. 2013 Dec;8(4):352-7. doi: 10.1016/j.cbd.2013.10.002. Epub 2013 Oct 12.|||Regul Pept. 2014 Nov;194-195:69-76.|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med"	27	
FPDB00316	AP02318|||AP02318|||Pseudhymenochirin-1Pb|||DRAMP31857	IKIPSFFRNILKKVGKEAVSLIAGALKQS	Anti-S. aureus, activity value is MIC = 5||Anti-S. epidermidis, activity value is MIC = 1.25||Anti-E. faecalis, activity value is MIC = 10 uM||Anti-E. coli, activity value is MIC = 10 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5||Anti-Escherichia coli ATCC 25726, activity value is MIC = 10 uM||Anti-Staphylococcus aureus 127/08, activity value is MIC = 5 uM||Anti-Staphylococcus aureus 145/08, activity value is MIC = 10 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 2.5 uM||Anti-Staphylococcus epidermidis RP62A/1, activity value is MIC = 1.25 uM||Anti-Staphylococcus epidermidis T6/19, activity value is MIC = 2.5 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 10 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 20 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 20 uM||Anti-Acinetobacter baumannii NM8, activity value is MIC = 10 uM||Anti-Acinetobacter baumannii NM35, activity value is MIC = 5 uM||Anti-Stenotrophomonas maltophilia B32/1, activity value is MIC = 5 uM||Anti-Stenotrophomonas maltophilia B5/5, activity value is MIC = 10 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 80 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 10 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 80 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 40 uM||Anti-Human lung carcinoma A549, activity value is IC50 = 7.2||Anti-Human breast adenocarcinoma MDA-MB-231, activity value is IC50 = 20||Anti-Human colon adenocarcinoma HT29, activity value is IC50 = 35||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-diabetes||Hemolytic	skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Pseudhymenochirus merlini|||skin secretions of the frog Pseudhymenochirus merlini (Pipidae)	Helix	skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Human umbilical vein endothelial cells HUVEC (50% Cell death at 5.6+-0.9 uM, Human erythrocytes (50% Hemolysis at 28+-2 uM, Mouse erythrocytes (50% Hemolysis at 30+-5 uM, Human umbilical vein endothelial cells HUVEC (50% Cell death at 27+-3 uM|||Human red blood cells (RBC): LC50>403 uM|||moderate hemolytic (LC50 28 uM)	"Conlon JM, Prajeep M, Mechkarska M, Coquet L, Leprince J, Jouenne T, Vaudry H, King JD.2013 Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med|||24212286, 25447194, 26606380|||Comp Biochem Physiol Part D Genomics Proteomics
. 2013 Dec;8(4):352-7. doi: 10.1016/j.cbd.2013.10.002. Epub 2013 Oct 12.|||Regul Pept. 2014 Nov;194-195:69-76.|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med"	29	
FPDB00317	AP02309|||AP02309|||Hymenochirin-1Pa|||Hymenochirin-1Pa|||AP02309|||DRAMP31853	LKLSPKTKDTLKKVLKGAIKGAIAIASMA	Anti-S. maltophilia, activity value is MIC = 0.6||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 10 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 20 uM||Anti-and weakly against C. albicans, activity value is MIC = 80 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2.5 uM||Anti-Escherichia coli ATCC 25726, activity value is MIC = 10 uM||Anti-Staphylococcus aureus 145/08, activity value is MIC = 2.5 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 1.25 uM||Anti-Staphylococcus epidermidis RP62A/1, activity value is MIC = 1.25 uM||Anti-Staphylococcus epidermidis T6/19, activity value is MIC = 1.25 uM||Anti-Staphylococcus epidermidis T37/8, activity value is MIC = 1.25 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 20 uM||Anti-Escherichia coli ATCC 25726, activity value is MIC = 5 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 10 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 20 uM||Anti-Acinetobacter baumannii NM8, activity value is MIC = 5 uM||Anti-Acinetobacter baumannii NM35, activity value is MIC = 5 uM||Anti-Acinetobacter baumannii NM75, activity value is MIC = 2.5 uM||Anti-Acinetobacter baumannii NM109, activity value is MIC = 5 uM||Anti-Acinetobacter baumannii NM124, activity value is MIC = 2.5 uM||Anti-Stenotrophomonas maltophilia B32/1, activity value is MIC = 2.5 uM||Anti-Stenotrophomonas maltophilia B32/4, activity value is MIC = 1.25 uM||Anti-Stenotrophomonas maltophilia U8908, activity value is MIC = 5 uM||Anti-Stenotrophomonas maltophilia B5/5, activity value is MIC = 2.5 uM||Anti-Stenotrophomonas maltophilia B6/2, activity value is MIC = 1.25 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 80 uM||Anti-Human lung carcinoma A549, activity value is IC50 = 1.2||Anti-Human breast adenocarcinoma MDA-MB-231, activity value is IC50 = 3.1||Anti-Human colon adenocarcinoma HT29, activity value is IC50 = 12.3||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic	skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Pseudhymenochirus merlini|||Pseudhymenochirus merlini|||skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||skin secretions of the frog Pseudhymenochirus merlini (Pipidae)	Helix	skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Human umbilical vein endothelial cells HUVEC (IC50 at 7.7+-0.7 uM, Human erythrocytes (50% Hemolysis at 162+-13 uM|||Human umbilical vein endothelial cells HUVEC (IC50 at 7.7+-0.7 uM, Human erythrocytes (50% Hemolysis at 162+-13 uM|||Human red blood cells (RBC): LC50=162±13 uM	"Conlon JM, Prajeep M, Mechkarska M, Coquet L, Leprince J, Jouenne T, Vaudry H, King JD.2013 Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357. Pub-Med|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357. Pub-Med|||24212286, 25241629|||24212286, 25241629|||Comp Biochem Physiol Part D Genomics Proteomics
. 2013 Dec;8(4):352-7. doi: 10.1016/j.cbd.2013.10.002. Epub 2013 Oct 12.|||Peptides. 2014 Nov;61:114-21.|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357. Pub-Med"	29	
FPDB00318	AP00566|||AP00566|||Dybowskin-3 , Brevinin-2DYc|||Dybowskin-3 , Brevinin-2DYc|||AP00566|||DRAMP01250	GLFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||Anti-M. luteus, activity value is MIC = 1.9 uM||Anti-v/v). The same amino acid sequence was also found by Conlon JM et al. as Brevinin-2DYc from Rana dybowskii (Brevinin-2DYc/d is active against E. coli and S. aureus, activity value is MIC = 15 uM||Anti-and S. lactis, activity value is MIC = 37.5 uM||Anti-C. albicans, activity value is MIC = 50 uM||Antibacterial||Anti-M. luteus, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 30 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 50 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 60 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 60 ug/ml||Anti-Escherichia coli, activity value is MIC = 15 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 15 ug/ml||Anti-Candida albicans, activity value is MIC = 100 ug/ml||Anti-S. aureus, activity value is MIC = 9 uM||Anti-B. subtilis, activity value is MIC = 15.1 uM||Anti-S. epidermidis, activity value is MIC = 18.1 uM||Anti-S. dysenteriae, activity value is MIC = 18.1 uM||Anti-E. coli, activity value is MIC = 4.5 uM||Anti-K. pneumoniae, activity value is MIC = 4.5 uM||Anti-P.mirabilis, activity value is MIC > 100 ug/ml||Anti-P.aeruginosa, activity value is MIC > 100 ug/ml||Anti-and C. albicans, activity value is MIC = 100 ug/ml||Anti-B. cereus, activity value is MIC = 37.5 uM||Anti-Micrococcus luteus ATCC4698, activity value is MIC = 39 ug/ml||Anti-Staphylococcus aureus KCTC3881, activity value is MIC = 50 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 60 ug/ml||Anti-Staphylococcus epidermidis ATCC12228, activity value is MIC = 60 ug/ml||Anti-Shigella dysenteriae ATCC9752, activity value is MIC = 15 ug/ml||Anti-Escherichia coli KCTC2433, activity value is MIC = 15 ug/ml||Anti-Klebsiella pneumoniae ATCC10031, activity value is MIC > 100 ug/ml||Anti-Candida albicans ATCC36232, activity value is MIC = 100 ug/ml	Rana dybowskii, or Rana nigromaculata, Asia|||Rana dybowskii, or Rana nigromaculata, Asia|||Rana dybowskii [Dybovsky frog]|||Rana dybowskii [Dybovsky frog]|||Rana dybowskii, or Rana nigromaculata, Asia|||Rana dybowskii (Korea brown frog)	N/A	"Percent hemolysis 1.86%|||The document mentions hemolysis-related information; the specific hemolysis values are as follows:

-Dybowskin-1: Hemolysis rate is 0.99%.
-Dybowskin-2: Hemolysis rate is 10.99%.
-Dybowskin-3: Hemolysis rate is 1.86%.
-Dybowskin-4: Hemolysis rate is 47.58%.
-Dybowskin-5: Hemolysis rate is 17.84%.
-Dybowskin-6: Hemolysis rate is 59.41%.|||hRBC (1.86% hemolysis at 100 ug/ml)|||hRBC (1.86% hemolysis at 100 ug/ml)|||At the test concentration of 100 ug/ml, the hemolysis rate of Dybowskin-3 on human red blood cells is only 1.86%.|||[Ref:17698251] It has 1.86% hemolytic activity at 100 ug/ml against human red blood cells|||Showed ~50% hemolysis at (100 ug/ml peptide to 2% human RBCs, v/v)."	"Peptides 2007; 28: 1532-1539. PubMed.|||Peptides
. 2007 Aug;28(8):1532-9. doi: 10.1016/j.peptides.2007.07.002. Epub 2007 Jul 7.|||17698251 , 17688900|||17698251 , 17688900|||Peptides 2007; 28: 1532-1539. PubMed.|||Ref.17698251|||Peptides 2007; 28: 1532-1539. PubMed."	33	
FPDB00319	AP00601|||AP00601|||Brevinin-1DYa|||Amurin-2c|||Amurin-2c|||AP00601|||DRAMP02016	FLSLALAALPKFLCLVFKKC	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer||Anti-E. coli and S. aureus, activity value is MIC < 15 uM||Anti-C. albicans, activity value is MIC = 32 uM||Antibacterial ; Rana dybowskii [Dybovsky frog]||Antibacterial||Anti-S. aureus, activity value is MIC = 32 uM||Anti-E. coli, activity value is MIC > 512 uM||Anti-MRSA, activity value is MIC = 32 uM||Antimicrobial||Anti-Gram+||Anti-Gram-	Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii [Dybovsky frog]|||Synthetic construct|||Rana dybowskii (Dybovsky's frog) (Korean brown frog)	Helix	"strongly hemolytic LC50<5 uM|||The document only explicitly provides the hemolytic values of three brevinin-1 family peptides in the skin extract of the Japanese brown frog (Rana dybowskii) (expressed as the concentration LC_{50} causing 50% hemolysis of human red blood cells), with the specific data as follows:

Brevinin-1DYa: hemolytic value LC_{50} < 5 μM, minimum inhibitory concentration (MIC) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) both < 15 μM;
Brevinin-1DYb: hemolytic value LC_{50} < 5 μM, MIC against E. coli and S. aureus both < 15 μM;
Brevinin-1DYc: hemolytic value LC_{50} < 5 μM, MIC against E. coli and S. aureus both < 15 μM.

In addition, the document also mentioned the following information:

Brevinin-1DYd and Brevinin-1DYe were not accurately measured for hemolytic values due to their low content;
Brevinin-2 family peptides Brevinin-2DYb, Brevinin-2DYc/d, and Brevinin-2DYe were only tested for antibacterial activity (MIC against E. coli and S. aureus: 15–30 μM) and no hemolytic values were reported;
Temporin-1DYa, lacking the basic amino acid residues common to the temporin family, showed no or very weak hemolytic activity against red blood cells, and no specific LC_{50} value was provided.|||The document mentions that peptides of the brevinin-1 family have strong hemolytic activity against human red blood cells, with a half-hemolysis concentration (LC₅₀) of less than 5 µM.|||Horse RBC (HC50 = 17 uM)|||Horse RBC (HC50 = 17 uM)|||LC₅₀<5 uM"	"Toxicon 2007; 50: 746-756. PubMed.|||Toxicon 2007; 50: 746-756. PubMed.|||Toxicon
. 2007 Nov;50(6):746-56. doi: 10.1016/j.toxicon.2007.06.023. Epub 2007 Jul 4.|||https://pubmed.ncbi.nlm.nih.gov/17688900|||29366784|||29366784|||Toxicon 2007; 50: 746-756. PubMed.|||Toxicon. 2007 Nov;50(6):746-756."	20	
FPDB00320	AP00602|||AP00602|||Brevinin-1DYb|||Amurin|||Amurin|||AP00602|||DRAMP02018	FLSLALAALPKLFCLIFKKC	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer||Anti-E. coli and S. aureus MRSA, activity value is MIC = 15||Anti-inactive E.coli, activity value is MIC > 512 uM||Antibacterial ; Rana dybowskii [Dybovsky frog]||Antibacterial||Anti-S. aureus, activity value is MIC = 32 uM||Anti-E. coli, activity value is MIC > 512 uM||Anti-C. albicans, activity value is MIC = 32 uM||Anti-MRSA, activity value is MIC = 32 uM||Antimicrobial||Anti-Gram+||Anti-Gram-	Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii [Dybovsky frog]|||Synthetic construct|||Rana dybowskii (Dybovsky's frog) (Korean brown frog)	Helix	"strongly hemolytic LC50<5 uM|||The document only explicitly provides the hemolytic values of three brevinin-1 family peptides in the skin extract of the Japanese brown frog (Rana dybowskii) (expressed as the concentration LC_{50} causing 50% hemolysis of human red blood cells), with the specific data as follows:

Brevinin-1DYa: hemolytic value LC_{50} < 5 μM, minimum inhibitory concentration (MIC) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) both < 15 μM;
Brevinin-1DYb: hemolytic value LC_{50} < 5 μM, MIC against E. coli and S. aureus both < 15 μM;
Brevinin-1DYc: hemolytic value LC_{50} < 5 μM, MIC against E. coli and S. aureus both < 15 μM.

In addition, the document also mentioned the following information:

Brevinin-1DYd and Brevinin-1DYe were not accurately measured for hemolytic values due to their low content;
Brevinin-2 family peptides Brevinin-2DYb, Brevinin-2DYc/d, and Brevinin-2DYe were only tested for antibacterial activity (MIC against E. coli and S. aureus: 15–30 μM) and no hemolytic values were reported;
Temporin-1DYa, lacking the basic amino acid residues common to the temporin family, showed no or very weak hemolytic activity against red blood cells, and no specific LC_{50} value was provided.|||The document mentions that peptides of the brevinin-1 family exhibit strong hemolytic activity against human red blood cells, with a half-maximal hemolytic concentration (LC₅₀) of less than 6 µM.|||Horse RBC (HC50 = 4.7 uM)|||Horse RBC (HC50 = 4.7 uM)|||LC₅₀<5 uM"	"Toxicon 2007; 50: 746-756. PubMed|||Toxicon 2007; 50: 746-756. PubMed.|||Toxicon
. 2007 Nov;50(6):746-56. doi: 10.1016/j.toxicon.2007.06.023. Epub 2007 Jul 4.|||https://pubmed.ncbi.nlm.nih.gov/17688900|||29366784|||29366784|||Toxicon 2007; 50: 746-756. PubMed.|||Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.Toxicon. 2007 Nov;50(6):746-756."	20	
FPDB00321	AP00605|||AP00605|||AP00606|||CAMPSQ2810|||DRAMP01754	ILPILSLIGGLLGK	Anti-Gram+||anti-sepsis||Antibiofilm||Anticancer||Anti-S. lactis, activity value is MIC = 41 uM||Anti-Staphylococcus aureus, activity value is MIC = 41 uM||Anti-Bacillus cereus, activity value is MIC = 41 uM||Anti-Streptococcus lactis, activity value is MIC = 41 uM||Anti-Escherichia coli, activity value is MIC > 100 uM	Rana chensinensis, China, Asia|||Rana chensinensis, China, Asia (also: peptide conjugates)|||Rana chensinensis, China, Asia|||Rana chensinensis [Chinese brown frog]|||Rana chensinensis (Chinese brown frog)	Helix	"The 50% hemolytic concentration (LD_{50}) of brevinin-1CEa on human red blood cells is 48 μM. The 50% hemolytic concentration (LD_{50}) of temporin-1CEa on human red blood cells is 230 μM. The 50% hemolytic concentration (LD_{50}) of temporin-1CEb on human red blood cells is 112 μM. The 50% hemolytic concentration (LD_{50}) of chensinin-1 on human red blood cells is >500 μM.|||The document mentioned hemolysis-related content. The specific hemolysis values are as follows:

- Brevinin-1CEa: The concentration causing 50% hemolysis of human red blood cells (LD₅₀) is 48 uM.
- Temporin-1CEa: LD₅₀ is 230 uM.
- Temporin-1CEb: LD₅₀ is 112 uM.
- Chensinin-1: No hemolytic activity at a concentration of 500 uM (LD₅₀ > 500 uM).|||The hemolytic values of antimicrobial peptides synthesized in the skin of Chinese brown frogs (Rana chensinensis), as explicitly mentioned in the document, measured against human red blood cells (expressed as half-maximal hemolytic concentration LD_{50}), are as follows:

- The hemolytic value LD_{50} of Brevinin-1CEa is 48 μM;
- The hemolytic value LD_{50} of Temporin-1CEa is 230 μM;
- The hemolytic value LD_{50} of Temporin-1CEb is 112 μM;
- The hemolytic value LD_{50} of the novel peptide Chensinin-1 is greater than 500 μM (i.e., no obvious hemolytic activity is observed even at 500 μM).

Note: LD_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; lower values indicate stronger hemolytic activity. Among them, Brevinin-1CEa has the strongest hemolytic activity (LD_{50} = 48 μM), and Chensinin-1 has the weakest."	"Zoolog Sci. 2009 Mar;26(3):220-6. PubMed|||2009 Mar;26(3):220-6. doi: 10.2108/zsj.26.220.|||Zoolog Sci
. 2009 Mar;26(3):220-6. doi: 10.2108/zsj.26.220.||Shang D et al., 2014|||19341344|||Zoolog Sci. 2009 Mar;26(3):220-6. PubMed."	14	
FPDB00322	AP00634	KYYGNGVTCGKHSCSVDWGKATTCIINNGAMAWATGGHQGNHKC	Anti-Gram+ & Gram-||Spermicidal||Anticancer||Anti-L. sakei subsp. sakei CIP 103139, activity value is MIC = 0.008 uM||Anti-E. faecium HKLHS, activity value is MIC = 0.256 uM||Anti-L. lactis CIP 102422, activity value is MIC = 0.256 uM||Anti-L. mesenteroides subsp. mesenteroides CIP 102305, activity value is MIC = 0.016 uM||Anti-L. innocua CIP 80.11, activity value is MIC = 0.256 uM||Anti-and L. monocytogenes CIP 82.110, activity value is MIC = 0.512 uM	Pediococcus acidilactici PAC-1.0; also Lactobacillus plantarum BM-1; ; lactic acid bacteria	Combine Helix and Beta structure	N/A	Arch Biochem Biophys 1992; 295: 5-12|||Arch Biochem Biophys 1992; 295: 5-12||Makhloufi KM et al., 2013	44	
FPDB00323	AP00644|||1543|||1544|||1545|||1546|||2996|||2997|||2998|||2999|||3000|||3001|||3002|||3003|||3004|||3005|||3006|||3007|||3008|||3009|||3010|||3011|||3012|||3013|||3014|||3015|||3016|||3017|||3018|||3019|||3020|||3021|||3022|||3023|||3024|||3025|||3026|||3027|||3028|||3029|||3030|||3031|||DRAMP03812	GFFALIPKIISSPLFKTLLSAVGSALSSSGGQE	Anti-Gram+ & Gram-||Anticancer||activity value is IC50 = 15.74 ug/ml||activity value is IC50 = 15.4 ug/ml||activity value is IC50 = 14.51 ug/ml||activity value is IC50 = 14.52 ug/ml||62 % Cytotoxicity at 50 ug/ml||44 % Cytotoxicity at 25 ug/ml||4 % Cytotoxicity at 12.5 ug/ml||75 % Cytotoxicity at 50 ug/ml||70 % Cytotoxicity at 25 ug/ml||4 % Cytotoxicity at 3.125 ug/ml||78 % Cytotoxicity at 50 ug/ml||68 % Cytotoxicity at 25 ug/ml||5 % Cytotoxicity at 6.25 ug/ml||10 % Cytotoxicity at 3.125 ug/ml||90 % Cytotoxicity at 50 ug/ml||80 % Cytotoxicity at 25000 ug/||15 % Cytotoxicity at 12.5 ug/ml||12 % Cytotoxicity at 6.25 ug/ml||5 % Cytotoxicity at 3.125 ug/ml||88 % Cytotoxicity at 50 ug/ml||82 % Cytotoxicity at 25 ug/ml||40 % Cytotoxicity at 12.5 ug/ml||35 % Cytotoxicity at 6.25 ug/ml||35 % Cytotoxicity at 3.125 ug/ml||90 % Cytotoxicity at 25 ug/ml||30 % Cytotoxicity at 12.5 ug/ml||30 % Cytotoxicity at 6.25 ug/ml||30 % Cytotoxicity at 3.125 ug/ml||97 % Cytotoxicity at 50 ug/ml||95 % Cytotoxicity at 25 ug/ml||39 % Cytotoxicity at 12.5 ug/ml||28 % Cytotoxicity at 6.25 ug/ml||38 % Cytotoxicity at 3.125 ug/ml||Shai et al. demonstrated antibacterial activity in 1996. Active against E. coli||A. calcoaceticus||P. aeruginosa (25 uM)||S. typhirnuriunz (40 uM)||B. rnegateriurn||M. luteus||and B. subtilis (The MIC against other bacteria 3-13 uM).||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Cytotoxic	Red Sea moses sole, Pardachirus marmoratus|||synthetic construct	Helix	"The document mentions hemolysis-related content but does not specify exact values. The following is a summary of the relevant information:

- Hemolysis of Pardaxin:
Both natural and synthetic Pardaxin exhibit hemolytic activity; they can lyse red blood cells, but specific hemolytic concentrations or activity values are not mentioned.
- Experimental phenomena related to hemolysis:
- When the concentration of Pardaxin is between 10^{-4}-10^{-7} M, it can cause cell lysis (cytolysis), which may be related to the hemolytic mechanism, but does not directly correspond to hemolytic values.
- Synthetic Pardaxin forms ion channels in lipid bilayers, which may lead to hemolysis by disrupting membrane structure, but no specific hemolytic efficiency data is provided.

In summary, the document does not provide specific hemolytic values and only describes that Pardaxin exhibits hemolytic activity and related biological effects."	"FEBS Lett. 1988 Dec 19;242(1):161-6. PubMed|||FEBS Lett
. 1988 Dec 19;242(1):161-6. doi: 10.1016/0014-5793(88)81007-x.|||J Pept Sci. 2008 Apr;14(4):524-527."	33	L
FPDB00324	AP00723|||AP00723|||Decoralin|||DRAMP03056|||Decoralin|||AP00723	SLLSLIRKLIT	Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anticancer||Anti-negative E. coli ATCC 25922, activity value is MIC = 80 uM||Anti-and A. faecalis ATCC 8750, activity value is MIC = 40 uM||Anti-and yeast C. albicans . It only showed weak leishmanicidal activity, activity value is IC50 = 72 uM||Anti-Staphylococcus aureus NCTC 10571, activity value is MIC = 14 uM||Anti-Escherichia coli NCTC 8007, activity value is MIC = 297 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 579 uM||Anti-Acinetobacter sp, activity value is MIC = 0.86 uM||Anti-Enterobacter aerogenes, activity value is MIC = 290 uM||Anti-Klebsiella sp. Strain 3105, activity value is MIC = 290 uM||Anti-Providencia stuartii, activity value is MIC > 1000 uM||Anti-Proteus mirabilis, activity value is MIC > 1000 uM||Anti-Fungi: Botrytis cinerea, activity value is MIC = 0.5 ug/ml||Anti-Candida albicans, activity value is MIC = 100 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-S.aureus CCT 6538, activity value is MIC = 40 uM||Anti-S.saprophyticus, activity value is MIC = 40 uM||Anti-B.subtilis CCT 2471, activity value is MIC = 40 uM||Anti-B.thuringiensis, activity value is MIC = 40 uM||Anti-E.coli ATCC 25922, activity value is MIC = 80 uM||Anti-E.coli CCT 1371, activity value is MIC = 160 uM||Anti-K.pneumonia ATCC 13883, activity value is MIC = 80 uM||Anti-A.faecalis ATCC 8750, activity value is MIC = 40 uM||Anti-C.albicans, activity value is MIC = 40 uM||Anti-L.major promastigotes, activity value is IC50 = 72 uM||Anti-28105725 :Candida albicans, activity value is MIC = 6.25 uM||Anti-28795464: Micrococcus luteus A 270, activity value is MIC = 0.8 uM||Anti-Escherichia coli SBS 363, activity value is MIC = 1.6 uM||Anti-Salmonella arizonae ATCC 13314, activity value is MIC = 25 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 6.2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1.6 uM||Anti-Candida albicans MDM8, activity value is MIC = 0.8 uM	venom, solitary eumenine wasp, Oreumenes decoratus|||venom, solitary eumenine wasp, Oreumenes decoratus|||Synthetic construct|||Oreumenes decoratus (Potter wasp)|||Oreumenes decoratus|||venom, solitary eumenine wasp, Oreumenes decoratus, China, Asia|||venom, solitary eumenine wasp, Oreumenes decoratus, China, Asia	Helix	significant hemolytic activity|||EC₅₀=1000 uM	"Peptides. 2007 Dec;28(12):2320-7. Epub 2007 Sep 29. PubMed|||Peptides
. 2007 Dec;28(12):2320-7. doi: 10.1016/j.peptides.2007.09.017. Epub 2007 Sep 29.||Torres et al., 2018|||17981364, 28105725, 28795464||Refer PubMed ID 9596699||Refer PubMed ID 15155221|||Peptides. 2007 Dec;28(12):2320-2327.|||https://pubmed.ncbi.nlm.nih.gov/17981364,|||Peptides. 2007 Dec;28(12):2320-7. Epub 2007 Sep 29. PubMed.||Torres et al., 2018|||Peptides. 2007 Dec;28(12):2320-7. Epub 2007 Sep 29. PubMed."	11	
FPDB00325	AP00770|||DRAMP01367	GLLGLLGSVVSHVLPAITQHL	Anti-Gram+ & Gram-||Anticancer||Anti-Bacillus cereus, activity value is MIC = 100 ug/ml||Anti-Bacillus cereus, activity value is MIC = 6 ug/ml||Anti-Listeria innocua, activity value is MIC = 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml	Litoria eucnemis, Australia|||Litoria eucnemis (Australian anurans)	N/A	Caerin 1.1： >250 ug/ml	Peptides 2004; 25: 1035-1054	21	
FPDB00326	AP00779|||4511|||4512|||4513|||4514|||4515|||4516|||4517|||4518|||4519|||4520|||4521|||4522|||4523|||4524|||4525|||4526|||4527|||4528|||4529|||4530|||4531|||4570|||4573|||AP00779|||Winter flounder 1a1|||DRAMP02349|||Winter flounder 1a1|||AP00779	GRRKRKWLRRIGKGVKIIGGAALDHL	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anticancer||5% cytotoxic at 5 uM||5% cytotoxic at 10 uM||30-35% cytotoxic at 25 uM||60% cytotoxic at 50 uM||5-10% cytotoxic at 5 uM||10% cytotoxic at 10 uM||30% cytotoxic at 5 uM||50% cytotoxic at 10 uM||70% cytotoxic at 25 uM||80-85% cytotoxic at 50 uM||40-50% cytotoxic at 10 uM||60-70% cytotoxic at 25 uM||15-20% cytotoxic at 5 uM||80% cytotoxic at 25 uM||85-90% cytotoxic at 50 uM||~0% cytotoxic at 5 uM||70% cytotoxic at 50 uM||60-70% cytotoxic at 50 uM||Anti-A. salmonicida 99-1, activity value is MIC = 2 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 4 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-E. coli CGSC 4908, activity value is MIC = 2 ug/ml||Anti-E. coli UB1005, activity value is MIC = 8 ug/ml||Anti-E. coli DC2, activity value is MIC = 2 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 8 ug/ml||Anti-MRSA C623, activity value is MIC = 8 ug/ml||Anti-C. albicans C627, activity value is MIC = 4 ug/ml||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 2 ug/ml||Anti-Aeromonas salmonicida 97-4, activity value is MIC = 4 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-Salmonella enterica serovar Typhimurium 14028s, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 2 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 2 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 8 ug/ml||Anti-Escherichia coli DC2, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus C623, activity value is MIC = 8 ug/ml||Anti-Highly active against active against A. salmonicida 99-1, activity value is MIC = 2 uM||Anti-A. salmonicida 97-4, activity value is MIC = 4 uM||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 uM||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 uM||Anti-P. aeruginosa K799, activity value is MIC = 2 uM||Anti-P. aeruginosa Z61, activity value is MIC = 1 uM||Anti-E. coli CGSC4908 or UB1005 or DC2, activity value is MIC = 2||Anti-S. epidermidis C621, activity value is MIC = 8 uM||Anti-methicillin-resistant S. aureus C623 MRSA, activity value is MIC = 8 uM||Anti-C. albicans C627, activity value is MIC = 4 uM	winter flounder 1a-1, Pleuronectes americanus|||winter flounder 1a-1, Pleuronectes americanus|||winter flounder 1a-1, Pleuronectes americanus|||Pseudopleuronectes americanus [Winter flounder]|||Pseudopleuronectes americanus (Winter flounder 3)|||Pseudopleuronectes americanus [Winter flounder]|||winter flounder 1a-1, Pleuronectes americanus	N/A	N/A	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.||Hou et al., 2022	26	L
FPDB00327	AP00780|||DRAMP31474	GRRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQA	Anti-Gram+ & Gram-||Anticancer||Antimicrobial||Antiviral	milk, Homo sapiens|||milk, Homo sapiens|||Synthetic construct	Helix	N/A	Scand J Infect Dis. 1998;30(5):513-7. PubMed|||1998;30(5):513-7. doi: 10.1080/00365549850161557.|||Antiviral Res. 2007 Sep;75(3):258-65.	49	
FPDB00328	AP00793|||AP00793|||Bombinin H4	LIGPVLGLVGSALGGLLKKI	Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Hemolytic||Anticancer||Antibacterial ; Bombina variegata [Yellow-bellied toad]||Antibacterial||Anti-C. tropicalis . Also active against C. jeikeium ATCC BAA-949, activity value is MIC = 8 uM	Bombina variegata, Europe|||Bombina variegata, Europe|||Bombina variegata [Yellow-bellied toad]	Helix	Bombinin H1: Not detected Bombinin H3: 15.7 µM Bombinin H4: 14.6 µM Bombinin H5: Not detected Synthetic peptide B: 17 µM|||Hemolytic activity (Human red blood cells) = 14.6 uM	EMBO J. 1993; 12:4829-4832|||EMBO J. 1993; 12:4829-4832|||https://pubmed.ncbi.nlm.nih.gov/8223491|||EMBO J. 1993; 12:4829-4832||Mangoni ML et al. 2007	20	
FPDB00329	AP00809|||DRAMP32374	GIKCRFCCGCCTPGICGVCCRF	Anti-Gram+ & Gram-||Antiviral||Anticancer||Antimicrobial	tilapia, Oreochromis mossambicus|||tilapia, Oreochromis mossambicus|||Skin Secretion of the African Frog, Kassina senegalensis	Bridge	N/A	Mol Immunol 2007; 44: 1922-1934. PubMed|||2007 Mar;44(8):1922-34. doi: 10.1016/j.molimm.2006.09.031. Epub 2006 Oct 25.|||Mol Immunol 2007; 44: 1922-1934. PubMed	22	
FPDB00330	AP00810|||DRAMP31546	"	
QSHLSLCRWCCNCCRSNKGC"	Anti-Gram-||Anticancer||Antimicrobial||Antiviral	tilapia, Oreochromis mossambicus|||tilapia, Oreochromis mossambicus|||Oreochromis mossambicus	N/A	N/A	Mol Immunol 2007; 44: 1922-1934|||Peptides. 2018 Aug;106:91-95.	20	
FPDB00331	AP00819|||AP00819|||Temporin-1Oc1|||DRAMP01773	"	
FLPLLASLFSRLF"	Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer||Anti-S. aureus, activity value is MIC = 2 uM||Anti-Staphylococcus epidermidis 1457, activity value is MIC = 1.6 uM||Anti-Bacillus subtilis 168, activity value is MIC = 12.5 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 25 uM||Anti-C. glabrata ATCC 2001, activity value is MIC = 25 uM||Anti-C. tropicalis ATCC 13803, activity value is MIC = 1.6||Anti-S. epidermidis 1457, activity value is MIC = 1.6 uM||Anti-B. subtilis 168, activity value is MIC = 12.5 uM||Anti-C. albicans, activity value is MIC = 25 uM||Anti-C. glabrata, activity value is MIC = 25 uM||Anti-Staphylococcus aureus, activity value is MIC = 2 uM	Rana Ornativentris, Asia|||Rana Ornativentris, Asia|||Rana ornativentris|||Rana ornativentris (Japanese mountain brown frog)	N/A	Human RBCs (HL50 < 12.5 uM)	J Peptide Res 2001; 58: 349-356. PubMed|||J Peptide Res 2001; 58: 349-356. PubMed.|||2001 Nov;58(5):349-56. doi: 10.1034/j.1399-3011.2001.00947.x.|||17147973, 11892844, 29842923||Refer PubMed ID: 29842923|||J Peptide Res 2001; 58: 349-356. PubMed.||see ref	13	
FPDB00332	AP00832|||AP00832|||Maximin H1|||DRAMP01123|||Maximin H1|||AP00832|||DRAMP01123	"	
ILGPVISTIGGVLGGLLKNL"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anticancer||Antibacterial ; Bombina maxima [Giant fire-bellied toad]||Anti-Escherichia coli ATCC25922, activity value is MIC = 9 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 4.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 9 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 4.5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 9 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 4.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 1010, activity value is MIC = 9 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 9 ug/ml||Anti-and fungi C. albicans ATCC2002, activity value is MIC = 4.5 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	skin secretions, Bombina maxima, China, Asia|||skin secretions, Bombina maxima, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||skin secretions, Bombina maxima, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||skin secretions, Bombina maxima, China, Asia	N/A	"strongly hemolytic|||Maximins: At peptide concentrations up to 50 µg/ml, maximins peptides showed almost no hemolytic activity. Maximin H peptide: At a concentration of 50 µg/ml, all maximin H peptides were able to lyse 90-100% of rabbit red blood cells.|||Escherichia coli ATCC25922 ( MIC = 9 ug/ml ), Staphylococcus aureus ATCC2592 ( MIC = 4.5 ug/ml ), Bacillus pyocyaneus CMCCB1010 ( MIC = 9 ug/ml ), Candida albicans ATCC2002 ( MIC = 4.5 ug/ml )|||The document mentions information related to the hemolytic activity of antimicrobial peptides in the skin secretions of the large-webbed bell toad (Bombina maxima):

- Maxims (first group of peptides): Even at concentrations as high as 50 µg/ml, they show almost no hemolytic activity against red blood cells.

- Maxims H (second group of peptides): They have strong hemolytic activity, causing 90%-100% hemolysis of rabbit red blood cells at a concentration of 50 µg/ml.

In the experiments, the group treated with 1% Triton X-100 was used as the maximum hemolysis control, and the degree of hemolysis was assessed by measuring the absorbance at 595 nm. The results showed that maximins H peptides have a significantly stronger hemolytic effect on red blood cells than maximins."	Peptides 2002; 23: 427-435|||Peptides 2002; 23: 427-435|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23: 427-435||Lai R et al., 2012|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.	20	
FPDB00333	AP00861|||AP00861|||Amolopin-1b|||DRAMP01341|||Amolopin-1b|||AP00861|||DRAMP01341	"	
FLPLAVSLAANFLPKLFCKITKKC"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 5.5 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 2.2 ug/ml||Anti-Escherichia coli, activity value is MIC = 6.5 ug/ml||Anti-Candida albicans, activity value is MIC = 7.5 ug/ml||Anti-Gram+ S. aureus, activity value is MIC = 5.5 ug/ml||Anti-B. dysenteriae, activity value is MIC = 2.2||Anti-and fungi C. albicans, activity value is MIC = 7.5 ug/ml	Amolops loloensis, China, Asia|||Amolops loloensis, China, Asia|||Amolops loloensis [rufous-spotted torrent frog]|||Amolops loloensis (Rufous-spotted torrent frog)|||Amolops loloensis [rufous-spotted torrent frog]|||Amolops loloensis, China, Asia|||Amolops loloensis (Rufous-spotted torrent frog)	N/A	strong hemolytic activity with a LD50 of 5000 ug/ml|||Brevinins-ALb: 5 µg/ml Temporins-ALa: None|||Staphylococcus aureus ( MIC = 5.5 ug/ml ), Escherichia coli ( MIC = 6.5 ug/ml ), Bacillus dysenteriae ( MIC = 2.2 ug/ml ), Candida albicans ( MIC = 7.5 ug/ml )	Peptides 2006; 27: 3085-3091|||Peptides 2006; 27: 3085-3091|||17000029|||Peptides. 2006 Dec;27(12):3085-3091.|||17000029|||Peptides 2006; 27: 3085-3091	24	
FPDB00334	AP00863|||AP00863|||Temporins-ALa|||DRAMP01339|||Temporins-ALa|||AP00863|||DRAMP01339	FLPIVGKLLSGLSGLL	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||Anti-S. aureus, activity value is MIC = 2 ug/ml||Anti-E. coli, activity value is MIC = 3 ug/ml||Anti-B. dysenteriae, activity value is MIC = 1.5 ug/ml||Anti-C. albicans, activity value is MIC = 6.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 2 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 1.5 ug/ml||Anti-Escherichia coli, activity value is MIC = 3 ug/ml||Antibacterial||Anti-Gram+ S. aureus, activity value is MIC = 2 ug/ml||Anti-B. dysenteriae, activity value is MIC = 1.5||Anti-and fungi C. albicans, activity value is MIC = 6.5 ug/ml	the rufous-spotted torrent frog, Amolops loloensis, China, Asia|||the rufous-spotted torrent frog, Amolops loloensis, China, Asia|||Amolops loloensis|||Amolops loloensis (Rufous-spotted torrent frog)|||Amolops loloensis [Rufous-spotted torrent frog]|||the rufous-spotted torrent frog, Amolops loloensis, China, Asia|||Amolops loloensis (Rufous-spotted torrent frog)	N/A	had little hemolytic activity|||Brevinins-ALb: 5 µg/ml Temporins-ALa: None|||Rabbit red blood cells (Slight hemolysis observed)|||In the study of antimicrobial peptides from the skin of the brown-spotted torrent frog, rabbit red blood cells were used as the test subject. The half-maximal hemolytic concentration (LD₅₀) of Brevinins-ALb was 5 μg/ml, and at a concentration of 20 μg/ml, it could lyse 96% of rabbit red blood cells, whereas Temporins-ALa showed almost no hemolytic activity.|||Rabbit red blood cells (Slight hemolysis observed)	Peptides 2006; 27: 3085-3091|||Peptides 2006; 27: 3085-3091|||17000029|||Peptides. 2006 Dec;27(12):3085-3091.|||17000029|||Peptides 2006; 27: 3085-3091	16	
FPDB00335	AP00871|||DRAMP01793	"	
FLPFLKSILGKIL"	Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Anti-Antibacterial activity was not reported due to a limited amount of material. We filled up this gap by using a synthetic peptide. Active against S. aureus USA300, activity value is MIC = 1.6||Anti-S. epidermidis 1457, activity value is MIC = 1.6 uM||Anti-B. subtilis 168, activity value is MIC = 12.5||Anti-C. albicans, activity value is MIC = 12.5 uM||Anti-C. glabrata, activity value is MIC = 12.5 uM||Antimicrobial	Florida bog frog, Rana okaloosae, North America|||Rana okaloosae (Florida bog frog)	Helix	N/A	Regul Pept 2007; 138: 87-93. PubMed|||Regul Pept 2007; 138: 87-93. PubMed.|||2007 Feb 1;138(2-3):87-93. doi: 10.1016/j.regpep.2006.08.007. Epub 2006 Sep 26.|||Regul Pept 2007; 138: 87-93.	13	
FPDB00336	AP00878|||AP00878|||Brevinin-1BYa|||DRAMP01960|||Brevinin-1BYa|||AP00878|||DRAMP01960	"	
FLPILASLAAKFGPKLFCLVTKKC"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-V3577, activity value is MIC = 3||Anti-V65A, activity value is MIC = 5||Anti-B51a/5, activity value is MIC = 5 uM||Anti-4426, activity value is MIC = 5||Anti-also Gram- E. coli ATCC 25922, activity value is MIC = 17||Anti-K. pneumoniae KK3 9904, activity value is MIC = 40 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 10 uM||Anti-P.mirabilis, activity value is MIC > 40 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 5 uM||Anti-Streptococcus Group B HNTCC 80130, activity value is MIC = 10 uM||Anti-S. epidermidis RP62A, activity value is MIC = 5 uM||Anti-and S. aureus NCTC 8352, activity value is MIC = 2 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 2 uM||Anti-Escherichia coli, activity value is MIC = 17 uM||Anti-Candida albicans, activity value is MIC = 3 uM||Antimicrobial||Anti-Gram+||Anti-Gram-	skin secretions, the foothill yellow-legged frog, Rana boylii, North America|||skin secretions, the foothill yellow-legged frog, Rana boylii, North America|||Rana boylii [Foothill yellow-legged frog]|||Rana boylii (Foothill yellow-legged frog)|||Rana boylii [Foothill yellow-legged frog]|||skin secretions, the foothill yellow-legged frog, Rana boylii, North America|||Rana picturata (Malaysian fire frog) (Hylarana picturata)	Helix	strong haemolytic LD50 =10 uM|||Brevinin-1BYa：LD₅₀ = 10 uM[Ser¹⁸,Ser²⁴] Brevinin-1BYa：LD₅₀ = 80 uM|||It is highly hemolytic (HC50 = 4-10 uM).	Int J Antimicrob Agents 2006; 27: 525-529|||Int J Antimicrob Agents 2006; 27: 525-529|||14531844|||J Pept Res. 2003 Nov;62(5):207-213.||Ref.14531844|||14531844|||Int J Antimicrob Agents 2006; 27: 525-529|||Toxicon. 2008 Sep 1;52(3):465-473.	24	
FPDB00337	AP00952|||1425|||1794|||1946|||2098|||2250|||2545|||2688|||AP00952|||MSI-78|||Pexiganan|||MSI-78, MSIEP	GIGKFLKKAKKFGKAFVKILKK	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-inflammatory||Wound healing||Anticancer||75% Cytotoxicity at 0.5 ug/ml||activity value is LD50 = 31 ug/ml||activity value is LD50 = 34 ug/ml||activity value is LD50 = 140 ug/ml||activity value is LD50 = 66 ug/ml||Anti-91% were susceptible to MSI-78 tested at a break-point of 64 ug/ml . Active against Acinetobacter sp. 10 strains, activity value is MIC = 4||Anti-A. faecalis 5 strains, activity value is MIC = 4||Anti-C. diversus 10 strains, activity value is MIC = 8||Anti-C. freundii 25 strains, activity value is MIC = 8||Anti-C. jeikeium, activity value is MIC = 0.125||Anti-E. aerogenes 25 strains, activity value is MIC = 8||Anti-E. cloacae 25 strains, activity value is MIC = 1||Anti-E.faecalis 30 strains, activity value is MIC > 256 ug/ml||Anti-E. coli 30 strains, activity value is MIC = 8||Anti-K. oxytoca 10 strains, activity value is MIC = 8||Anti-K. pneumoniae 25 strains, activity value is MIC = 8||Anti-P. aeruginosa 25 strains, activity value is MIC = 8||Anti-P. fluorescens 5 strains, activity value is MIC = 2||Anti-P. stutzeri 5 strains, activity value is MIC = 4||Anti-S. aureus MRSA 10 strains, activity value is MIC = 16||Anti-S. aureus MSSA 15 strains, activity value is MIC = 0.125||Anti-S. epidermidis 25 strains, activity value is MIC = 0.125||Anti-S. haemolyticus 10 strains, activity value is MIC = 408 ug/ml||Anti-S. hominis 5 strains, activity value is MIC = 2||Anti-S. simulans 5 strains, activity value is MIC = 0.125||Anti-S. warneri 5 strains, activity value is MIC = 0.125||Anti-S. xylosus 1 strain, activity value is MIC = 0.125 ug/ml||Anti-S. maltophilia 10 strains, activity value is MIC = 4||Anti-S. agalactiae 25 strains, activity value is MIC = 16||Anti-S. bovis 5 strains, activity value is MIC = 8||Anti-S. equinus 2 strains, activity value is MIC = 2||Anti-S. pyogenes 30 strains, activity value is MIC = 16||Anti-Streptococcus group C 5 strains, activity value is MIC = 16||Anti-Streptococcus group G 5 strains, activity value is MIC = 16||Anti-Viridans group streptococci 13 strains, activity value is MIC = 4||Anti-B. ovatus 7 strains, activity value is MIC = 4||Anti-B. ureolyticus 3 strains, activity value is MIC = 0.25||Anti-B. vulgatus 6 strains, activity value is MIC = 4 ug/ml||Anti-C. difficile 4 strains, activity value is MIC = 0.5||Anti-C. perfringens 5 strains, activity value is MIC = 8||Anti-C. ramosum 2 strains, activity value is MIC = 16 ug/ml||Anti-C. sporogenes 2 strains, activity value is MIC = 8||Anti-Clostridium sp, activity value is MIC = 32 ug/ml||Anti-P. anaerobius 6 strains, activity value is MIC = 32||Anti-P. asaccharolyticus 3 strains, activity value is MIC = 4||Anti-P. magnus 4 strains, activity value is MIC = 0.5||Anti-P. bivia 9 strains, activity value is MIC = 32||Anti-and P. melaninogenica 3 strains, activity value is MIC = 32||MIC against MRSA Staphylococcus aureus CCARM 3696||Bacillus subtilis KCTC 2213||Micrococcus luteus KCTC9341||vancomycin-resistant Enterococcus faecium CCARM 5028 (VRE)||Listeria mono-cytogenes KCTC 19111||multidrug-resistant Pseudomonas aeruginosa CCARM 2161(MDRPA)||Escherichia coli KCTC 1039||Klebsiella oxytoca KCTC 1686||Citrobacter fre-undii KCTC 2359 and Salmonella enterica KCTC 2930||Antibacterial	amino acid substitution, amphibians, animal-derived, natural derivative|||amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct	Helix	Staphylococcus aureus ATCC 29213 ( MIC = 8 16 ug/ml ), Staphylococcus aureus ATCC 33591 (methicillin resistant) ( MIC = 16 32 ug/ml ), Staphylococcus epidermidis ATCC 12228 ( MIC = 2 4 ug/ml ), Enterococcus faecium ATCC 51559 (vancomycin resistant) ( MIC = 8 ug/ml ), Enterococcus faecalis ATCC 29212 ( MIC = 64 ug/ml ), Group A Streptococcus ATCC 49399 ( MIC = 4 ug/ml ), Streptococcus pneumoniae ATCC 49619 ( MIC = 32 ug/ml ), Streptococcus bovis ATCC 49133 ( MIC = 4 ug/ml ), Bacillus cereus ATCC 11778 ( MIC = 8 ug/ml ), Micrococcus luteus ATCC 4698 ( MIC = 2 ug/ml ), Corynebacterium group A ATCC 49676 ( MIC = 2 4 ug/ml ), Escherichia coli ATCC 25922 ( MIC = 8 16 ug/ml ), Enterobacter cloacae ATCC 35030 ( MIC = 8 ug/ml ), Proteus mirabilis ATCC 29245 ( MIC = >256 ug/ml ), Serratia marcescens ATCC 8100 ( MIC = >256 ug/ml ), Helicobacter pylori ATCC 43504 ( MIC = 2 ug/ml ), Haemophilus influenzae ATCC 49247 ( MIC = 8 ug/ml ), Pseudomonas aeruginosa ATCC 27853 ( MIC = 8 16 ug/ml ), Bacteroides fragilis ATCC 90028 ( MIC = 2 4 ug/ml ), Bacteroides thetaiotaomicron ATCC 29741 ( MIC = 2 4 ug/ml ), Clostridium difficile ATCC 43255 ( MIC = 4 ug/ml ), Propionibacterium acnes ATCC 29399 ( MIC = 8 ug/ml ), Veillonella parvula ATCC 10790 ( MIC = 8 ug/ml )|||A. baumannii ATCC 19606 (MIC =2 ug/ml)|||MSI-78, [P. aeruginosa (MIC = 0.78 uM), E. coli (MIC = 1.56-3.12 uM), S. aureus (MIC = 0.78-1.56 uM), B. subtilis (MIC = 1.56 uM)]; MSIEP [(Isopeptide formation: K8, K14, and K18) - P. aeruginosa (MIC = 6.25-12.5 uM), E. coli (MIC = 12.5 uM), S. aureus (MIC = 6.25-12.5 uM), B. subtilis (MIC = 6.25-12.5 uM)]|||Even at a concentration of 200 ug/ml, the hemolysis rate of this peptide on human red blood cells remains < 1%.|||human RBC, 53% hemolysis at 512 ug/ml (HC50 512 ug/ml), less hemo.lytic.	"Ciba Found Symp. 1994;186:197-216; discussion 216-23. doi: 10.1002/9780470514658.ch12. PubMed|||J Antimicrob Chemother
. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. Epub 2013 Aug 14.|||1994:186:197-216; discussion 216-23.doi: 10.1002/9780470514658.ch12.||Fucks et al., 1998|||10103181|||30043322|||34043312|||Ciba Found Symp. 1994;186:197-216; discussion 216-23. doi: 10.1002/9780470514658.ch12. PubMed.||Fucks et al., 1998|||Ciba Found Symp. 1994;186:197-216; discussion 216-23. doi: 10.1002/9780470514658.ch12. PubMed."	22	L
FPDB00338	AP00964|||AP00964|||Dermaseptin-L1|||DRAMP01638|||Dermaseptin-L1|||AP00964|||DRAMP01638	"	
GLWSKIKEAAKAAGKAALNAVTGLVNQGDQPS"	Anti-Gram-||Antifungal||Anticancer||Anti-Dermaseptin-L1 was active against the Gram-negative bacterium E. coli, activity value is MIC = 8 uM||Antibacterial||Anti-Escherichia coli, activity value is MIC = 8 uM||Anti-Batrachochytrium dendrobatidis, activity value is MIC > 100 uM	Hylomantis lemur (Hylidae: Phyllomedusinae), South America|||Hylomantis lemur (Hylidae: Phyllomedusinae), South America|||Hylomantis lemur [Lemur leaf frog]|||Hylomantis lemur (Lemur leaf frog)|||Hylomantis lemur [Lemur leaf frog]|||Hylomantis lemur (Hylidae: Phyllomedusinae), South America|||Hylomantis lemur (Lemur leaf frog)	N/A	weakly hemolytic|||Dermaseptin-L1: Human red blood cells: LC₅₀ = 200 μMHepG2 human liver cancer cells: LC₅₀ = 45 μMPhylloseptin-L1: Human red blood cells: LC₅₀ = 40 μMHepG2 human liver cancer cells: LC₅₀ = 35 μM|||Human erythrocytes ( LC50 = 200 uM ), Human HepG2 cells ( LC50 = 45 uM )|||In the study of lemur leaf frog skin cell cytotoxic peptides, the half-maximal hemolytic concentration (LC₅₀) of Dermaseptin-L1 on human red blood cells was 200 µM, while the LC₅₀ of Phylloseptin-L1 on human red blood cells was 40 µM, with the latter exhibiting significantly higher hemolytic activity than the former.|||Human erythrocytes ( LC50 = 200 uM ), Human HepG2 cells ( LC50 = 45 uM )	Toxicon. 2007 Sep 15;50(4):498-506|||Toxicon. 2007 Sep 15;50(4):498-506|||17561225|||Toxicon. 2007 Sep 15;50(4):498-506.|||17561225|||Toxicon. 2007 Sep 15;50(4):498-506	32	
FPDB00339	AP00973|||AP00973|||Phylloseptin-L1|||Phylloseptin-L1|||AP00973|||DRAMP31672	"	
LLGMIPLAISAISALSKL"	Anti-Gram+||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-Phylloseptin-L1 was active against S. aureus, activity value is MIC = 8 uM||Anti-Batrachochytrium dendrobatidis, activity value is MIC = 100 uM||Anti-Staphylococcus aureus, activity value is MIC = 8 uM||Antimicrobial	Hylomantis lemur (Hylidae: Phyllomedusinae, South America; also skin secretion, red-eyed leaf frog, Agalychnis callidryas, Central America|||Hylomantis lemur (Hylidae: Phyllomedusinae, South America; also skin secretion, red-eyed leaf frog, Agalychnis callidryas, Central America|||Hylomantis lemur, Agalychnis callidryas [Lemur leaf frog, Red-eyed tree frog]|||Hylomantis lemur (Hylidae: Phyllomedusinae, South America; also skin secretion, red-eyed leaf frog, Agalychnis callidryas, Central America|||skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)	N/A	strongly hemolytic|||Dermaseptin-L1: Human red blood cells: LC₅₀ = 200 μMHepG2 human liver cancer cells: LC₅₀ = 45 μMPhylloseptin-L1: Human red blood cells: LC₅₀ = 40 μMHepG2 human liver cancer cells: LC₅₀ = 35 μM|||Human erythrocytes ( LC50 = 40 uM ), Human HepG2 cells ( LC50 = 35 uM )|||Human erythrocytes ( LC50 = 40 uM ), Human HepG2 cells ( LC50 = 35 uM )|||Human erythrocytes: LC50=200 uM	Toxicon. 2007 Sep 15;50(4):498-506|||Toxicon. 2007 Sep 15;50(4):498-506|||17561225|||17561225|||Toxicon. 2007 Sep 15;50(4):498-506|||Toxicon. 2007 Sep 15;50(4):498-506.	18	
FPDB00340	AP00979|||DRAMP00746|||AP00979|||DRAMP00746	"	
RECKTESNTFPGICITKPPCRKACISEKFTDGHCSKILRRCLCTKPC"	Antifungal||Insecticidal||Synergistic AMPs||Anticancer||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-F. oxysporum f. sp. vasinfectum, activity value is IC50 = 1 uM||Anti-L. maculans, activity value is IC50 = 0.8 uM||Anti-A. nidulans, activity value is IC50 = 0.8 uM||Anti-V. dahliae, activity value is IC50 = 0.75 uM||Anti-T. bisicola, activity value is IC50 = 0.8 uM||Anti-C-albicans, activity value is IC50 > 10 uM	ornamental tobacco flowers, Nicotiana alata|||Nicotiana alata (Winged tobacco) (Persian tobacco)|||ornamental tobacco flowers, Nicotiana alata|||Arabidopsis thaliana (Mouse-ear cress)	Combine Helix and Beta structure||Combine helix and strand structure	N/A	J Mol Biol. 2003 Jan 3;325(1):175-88. Pub-Med|||Plant Physiol. 2003 Mar;131(3):1283-1293.|||J Mol Biol. 2003 Jan 3;325(1):175-88. Pub-Med|||Plant Physiol. 2003 Mar;131(3):1283-1293.J Mol Biol. 2003 Jan 3;325(1):175-188.J Biol Chem. 2012 Jun 8;287(24):19961-72.J Biol Chem. 2008 May 23;283(21):14445-52.	47	
FPDB00341	AP00984|||DRAMP01043|||AP00984|||DRAMP01043	"	
QICKAPSQTFPGLCFMDSSCRKYCIKEKFTGGHCSKLQRKCLCTKPC"	Antifungal||Anticancer||Antimicrobial	tomato, Lycopersicon esculentum|||Lycopersicon esculentum|||tomato, Lycopersicon esculentum|||Lycopersicon esculentum	Combine Helix and Beta structure	N/A	Plant Mol Biol 1995; 28:691-711. PubMed|||Plant Mol Biol 1995; 28:691-711.|||Plant Mol Biol 1995; 28:691-711. PubMed.|||Plant Mol Biol 1995; 28:691-711.	47	
FPDB00342	AP01012|||AP01012|||Latarcin-3a|||DRAMP03229|||Latarcin-3a|||AP01012	SWKSMAKKLKEYMEKLKQRA	Anti-Gram+ & Gram-||Antifungal||Hemolytic||Antibiofilm||Anticancer||Anti-E. coli DH1, activity value is MIC = 2.5||Anti-P-aeruginosa, activity value is MIC > 40 uM||Anti-B. subtilis, activity value is MIC = 0.3||Anti-S. cerevisiae, activity value is MIC = 20 uM||Anti-E.coli ATCC 25922, activity value is MIC > 128 ug/ml||Anti-K.pneumoniae ATCC 13883, activity value is MIC > 128 ug/ml||Anti-P.aeruginosa KPC+ 003321199, activity value is MIC > 128 ug/ml||Anti-P.acnes ATCC 51277, activity value is MIC > 128 ug/ml||Antibacterial ; Synthetic construct||Anti-A. globiformis VKM Ac-1112, activity value is MIC = 0.3 uM||Anti-B. subtilis VKM B-501, activity value is MIC = 1.2 uM||Anti-E.coli DH5-alpha, activity value is MIC = 2.5 uM||Anti-E. coli MH1, activity value is MIC = 6 uM||Anti-P. pastoris GS115, activity value is MIC = 20 uM||Anti-S.cerevisiae Y190, activity value is MIC = 20 uM||Anti-Arthrobacter globiformis VKM Ac-1112, activity value is MIC = 0.3 uM||Anti-Bacillus subtilis VKM B-501, activity value is MIC = 1.2 uM||Anti-Escherichia coli DH5-alpha, activity value is MIC = 2.5 uM||Anti-Escherichia coli MH1, activity value is MIC = 6 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC > 40 uM||Anti-Pichia pastoris GS115, activity value is MIC = 20 uM||Anti-Saccharomyces cerevisiae Y190, activity value is MIC = 20 uM	venom, Lachesana tarabaevi, Central Asia|||venom, Lachesana tarabaevi, Central Asia|||Synthetic construct|||venom, Lachesana tarabaevi, Central Asia|||Lachesana tarabaevi (Spider)|||venom, Lachesana tarabaevi, Central Asia	Helix||Alpha helix	"Ltc1: 80Ltc2a: 6.0Ltc3a: >120Ltc3b: >120Ltc4a: >120Ltc4b: >120Ltc5: 40Ltc6a: >120Ltc7: >120|||A. globiformis VKM Ac-1112 ( MIC = 0.3 uM ), B. subtilis VKM B-501 ( MIC = 1.2 uM ), E.coli DH5-alpha ( MIC = 2.5 uM ), E. coli MH1 ( MIC = 6 uM ), P.aeruginosa PAO1 ( MIC = >40 uM ), P. pastoris GS115 ( MIC = 20 uM ), S.cerevisiae Y190 ( MIC = 20 uM)||Rabbit erythrocytes ( Hemolysis > 120 uM )|||Rabbit erythrocytes ( Hemolysis > 120 uM )|||According to the contents of the document, the hemolytic values of 9 latarcin peptides (Ltc 1, Ltc 2a, Ltc 3a, Ltc 3b, Ltc 4a, Ltc 4b, Ltc 5, Ltc 6a, Ltc 7) isolated from the venom of Tarschella (Lachesana tarabaevi) are as follows. The experiment was tested by fresh rabbit red blood cells and measured by the concentration of peptides causing red blood cell hemolysis:

Ltc 1: Exhibits moderate hemolytic activity (no specific concentration values provided; only the activity level is specified).
Ltc 2a: with strong hemolytic (no specific concentration value, only clear activity level).
Ltc 3a: red blood cells are highly resistant to it, and hemolysis is extremely weak (no specific concentration value, only the activity level is specified).
LTC 3b: Highly tolerant to red blood cells, with very low hemolytic activity (no specific concentration values provided; only the activity level is specified).
LTC-4a: Red blood cells exhibit high tolerance to it, with very low hemolytic activity (no specific concentration values are provided; only the activity level is specified).
Ltc 4b: Red blood cells exhibit high tolerance to it, with very low hemolytic activity (no specific concentration values are provided; only the activity level is specified).
Ltc 5: Exhibits moderate hemolytic activity (no specific concentration values provided; only the activity level is specified).
Ltc 6a: Red blood cells are highly resistant to it and have no antimicrobial activity (no specific concentration value, only activity grade is specified).
Ltc 7: Red blood cells exhibit high tolerance to it, and it demonstrates no antimicrobial activity (no specific concentration values are provided; only the activity level is specified).

Note: The document does not provide the specific value of half hemolysis concentration (LC_{50}) of each peptide causing 50% hemolysis. The hemolytic strength is only classified by descriptions such as &quot;highly tolerated&quot;, &quot;medium&quot; and &quot;strong&quot;. In the experiment, distilled water treatment group is used as 100 hemolysis control, and peptide-free treatment group is used as 0% hemolysis control. Hemoglobin release is measured by detecting absorbance at 414 nm to determine hemolysis.|||Ltc 1：80 uM；

• Ltc 2a：6 uM；

• Ltc 3a：120 uM；

• Ltc 3b：120 uM；

• Ltc 4a：120 uM；

• Ltc 4b：120 uM；

• Ltc 5：40 uM；

• Ltc 6a：120 uM；

• Ltc 7：120 uM。|||Rabbit erythrocytes ( Hemolysis > 120 uM )|||Tests to determine the hemolytic activity of latarcins were performed and showed that erythrocytes are highly resistant to Ltc 3a, Ltc 3b, Ltc 4a, Ltc 4b, Ltc 6a, and Ltc 7 (Table 3). Ltc 2a exhibited comparatively strong hemolytic activity, whereas Ltc 1 and Ltc 5 were moderately hemolytic. Ltc 6a and Ltc 9 (identified as putative AMPs) showed neither antimicrobial nor hemolytic activity."	J Biol Chem. 2006 Jul 28;281(30):20983-92. Pub-Med|||2006 Jul 28;281(30):20983-20992. doi: 10.1074/jbc.M602168200. Epub 2006 May 30.|||http://www.ncbi.nlm.nih.gov/protein/115311723|||J Biol Chem. 2006 Jul 28;281(30):20983-92. Pub-Med.|||J Biol Chem. 2006 Jul 28;281(30):20983-209892.||Ref.16735513|||16735513|||J Biol Chem. 2006 Jul 28;281(30):20983-92. Pub-Med.	20	
FPDB00343	AP01026|||Varv A	GLPVCGETCVGGTCNTPGCSCSWPVCTRN	Anticancer||Anti-Pseudomonas aeruginosa, activity value is MIC = 80 uM	Viola arvensis,Viola odorata, Viola tricolor, Viola baoshanensis, Viola yedoensis, and Viola biflora|||Viola odorata L. and Viola tricolor L	Bridge	N/A	J Nat Prod. 1998 Jan 23;61(1):77-81|||28669767	29	
FPDB00344	AP01031	"	
GVPICGETCTLGTCYTAGCSCSWPVCTRN"	Anticancer	Viola arvensis	Beta	N/A	J Nat Prod. 1999 Feb;62(2):283-6. Pub-Med	29	
FPDB00345	AP01036|||AP01036|||Cycloviolacin O2|||DRAMP00805	"	
GIPCGESCVWIPCISSAIGCSCKSKVCYRN"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anticancer||Anti-S. enterica serovar Typhimurium LT2 and E. coli in RDAs and MIC assays . Moderately active against S. aureus, activity value is MIC = 20||Anti-and C. albicans . A. baumannii, activity value is MIC = 4.2 uM||Anti-plant fungi F. oxysporum, activity value is MIC = 6||Anti-B. cinerea, activity value is MIC = 1.5 uM||Anti-F. graminearum, activity value is MIC = 6.25 uM||Anti-F. culmorum, activity value is MIC = 1.5 uM||Anti-C. utrechtense, activity value is MIC = 6.25 uM||Anti-A. alternatam, activity value is MIC = 1.5 uM||Anti-Escherichia coli, activity value is MIC = 20 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 10 uM||Anti-Staphylococcus aureus, activity value is MIC = 20 uM||Anti-Candida albicans, activity value is MIC = 20 uM||Insecticidal	Viola odorata and Viola japonica|||Viola odorata and Viola japonica|||Viola odorata L. and Viola tricolor L|||Viola biflora (Yellow wood violet) & Viola odorata (Sweet violet)	Bridge||Combine helix and strand structure	[Ref:16872274] It has 35% hemolytic activity at 1 uM and 60% hemolytic activity at 1.5 uM against human type A red blood cells	J Mol Biol. 1999 Dec 17;294(5):1327-36. Pub-Med.|||1999 Dec 17;294(5):1327-36. doi: 10.1006/jmbi.1999.3383.||ref 2024||Pränting M et al., 2010||Fensterseifer IC et al., 2014||Strömstedt AA et al., 2017||Slazak et al. 2018|||28669767|||J Mol Biol. 1999 Dec 17;294(5):1327-36. Pub-Med.||ref 2024||Pränting M et al., 2010||Fensterseifer IC et al., 2014||Strömstedt AA et al., 2017||Slazak et al. 2018|||J Mol Biol. 1999 Dec 17;294(5):1327-36. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12.J Mol Biol. 1999 Dec 17;294(5):1327-1336.Biochem J . 2006 Nov 15;400(1):1-12.	30	
FPDB00346	AP01121	"	
GIPCAESCVWIPCTVTALIGCGCSNKVCYN"	To be updated.	alpine violet Viola biflora	Bridge	N/A	Phytochemistry. 2008 Feb;69(4):939-52. Pub-Med.	30	
FPDB00347	AP01123	"	
GTFPCGESCVFIPCLTSAIGCSCKSKVCYKN"	To be updated.	alpine violet Viola biflora	Bridge	N/A	Phytochemistry. 2008 Feb;69(4):939-52. Pub-Med.	31	
FPDB00348	AP01124	"	
GLLPCAESCVYIPCLTTVIGCSCKSKVCYKN"	Anticancer	alpine violet Viola biflora	Bridge	N/A	Phytochemistry. 2008 Feb;69(4):939-52. Pub-Med.	31	
FPDB00349	AP01161	GRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLR	Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Chemotactic||anti-TB||anti-sepsis||Synergistic AMPs||Hemolytic||Anticancer||a recombinant peptide showed activity in vitro against bacteria (S. typhimurium||L. monocytogenes||E. coli||and S. aureus)||fungi C. neoformans||C. albicans||and parasites L. major||and parasites L. major.	NK cells; T lymphocytes; Homo sapiens|||gammadelta T cells, NK cells; T lymphocytes; Homo sapiens|||gammadelta T cells, NK cells; T lymphocytes; Homo sapiens|||NK cells; T lymphocytes; Homo sapiens	Helix	. Eluted fractions were all individually assayed for hemolytic activity. The fractions with the highest hemolytic activity were pooled and concentrated for use.	Science. 1998 Oct 2;282(5386):121-5. Pub-Med.|||1998 Oct 2;282(5386):121-5. doi: 10.1126/science.282.5386.121.||see the ref|||1998 Oct 2;282(5386):121-5. doi: 10.1126/science.282.5386.121.|||Science. 1998 Oct 2;282(5386):121-5. Pub-Med.||see the ref|||Science. 1998 Oct 2;282(5386):121-5. Pub-Med.	74	
FPDB00350	AP01196|||DRAMP00222	GETDPNTQLLNDLGNNMAWGAALGAPGGLGSAALGAAGGALQTVGQGLIDHGPVNVFIPVLIGPSWNGSGSGYNSATSSSGSGS	Anti-Gram-||Anticancer||Active against E. coli RYC1000||E. coli B||E. coli F.||E. coli ML35p||S. enterica Enteritidis||S. enterica Typhimurium||E. cloacae and K. pneumoniae  . The peptide lost its activity by amyloid formation (i.e. aggregates)  .||Anti-Escherichia coli F, activity value is MIC = 0.14 uM||Anti-Escherichia coli 363, activity value is MIC = 0.02 uM||Anti-Escherichia coli ML35p, activity value is MIC = 0.14 uM||Anti-Escherichia coli GM1, activity value is MIC = 0.04 uM||Anti-Escherichia coli GM1 KP1060, activity value is MIC = 0.65 uM||Anti-Escherichia coli W3110, activity value is MIC = 0.02 uM||Anti-Escherichia coli W3110-KP1344 Pms7, activity value is MIC = 0.08 uM||Anti-Escherichia coli W3110-6, activity value is MIC = 0.32 uM||Anti-Escherichia coli C600, activity value is MIC = 0.08 uM||Anti-Escherichia coli C600 pHX405, activity value is MIC = 0.16 uM||Anti-Salmonella enteritidis, activity value is MIC = 0.6 uM||Anti-Salmonella typhimurium, activity value is MIC = 1.2 uM	Klebsiella pneumoniae RYC492; human microbiota:gut, symbiont bacteria|||Klebsiella pneumoniae RYC492; human microbiota:gut, symbiont bacteria|||Klebsiella pneumoniae RYC492 (Gram-negative bacteria)	N/A	N/A	Arch Microbiol. 1984 Sep;139(1):72-5.|||Arch Microbiol. 1984 Sep;139(1):72-5.||Vassiliadis G et al. 2010||Bieler S et al 2005 JBC 280:26880	84	
FPDB00351	AP01239|||Cathelicidin-BF antimicrobial peptide|||CWA|||DRAMP02473|||Cathelicidin-BF antimicrobial peptide|||AP01239|||BF-30	"	
KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Enzyme inhibitor||Anticancer||Anti-Bacillus subtilis, activity value is MIC = 9.4 ug/ml||Anti-Bacillus pumilus, activity value is MIC = 9.4 ug/ml||Anti-Bacillus cereus, activity value is MIC = 1.2 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 1.2 ug/ml||Anti-DR, activity value is MIC = 2.3 ug/ml||Anti-DR, activity value is MIC = 9.4 ug/ml||Anti-DR, activity value is MIC = 18.7 ug/ml||Anti-Escherichia coliATCC25922, activity value is MIC = 2.3 ug/ml||Anti-DR, activity value is MIC = 1.2 ug/ml||Anti-DR, activity value is MIC = 0.6 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 4.7 ug/ml||Anti-DR, activity value is MIC = 75 ug/ml||Anti-Acinetobacter calcoaceticus, activity value is MIC = 2.3 ug/ml||Anti-Sphingobacterium siyangense, activity value is MIC = 9.4 ug/ml||Anti-Sacharibacillus kuerlensis, activity value is MIC = 4.7 ug/ml||Anti-Pseudomonas luteola, activity value is MIC = 1.2 ug/ml||Anti-DR, activity value is MIC = 4.7 ug/ml||Anti-DR, activity value is MIC = 0.3 ug/ml||Anti-DR, activity value is MIC = 150 ug/ml||Anti-Aspergillus terreus GIM3.34, activity value is MIC = 18.7 ug/ml||Anti-Aspergillus niculans, activity value is MIC = 18.7 ug/ml||Anti-Chaetomium globosum, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 4.7 ug/ml||Anti-Pichia pastoris, activity value is MIC = 0.3 ug/ml||E. coli K88||Anti-P. aeruginosa IS/DR, activity value is MIC = 2.3 ug/ml||Anti-P. aeruginosa 08031205 IS/DR, activity value is MIC = 9.4 ug/ml||Anti-P. aeruginosa 08031014 IS/DR, activity value is MIC = 18.7 ug/ml||Anti-Escherichia coli ATCC25922, activity value is MIC = 2.3 ug/ml||Anti-E. coli 08A852 IS/DR, activity value is MIC = 1.2 ug/ml||Anti-E. coli 08A866 IS/DR, activity value is MIC = 0.6 ug/ml||Anti-E. coli 08031017 IS/DR, activity value is MIC = 2.3 ug/ml||Anti-E. coli 08032813 IS/DR, activity value is MIC = 2.3 ug/ml||Anti-E. coli 08040726 IS/DR, activity value is MIC = 0.6 ug/ml||Anti-E. coli 08040722 IS/DR, activity value is MIC = 0.6 ug/ml||Anti-Klebsiella pneumoniae IS/DR, activity value is MIC = 4.7 ug/ml||Anti-K. pneumoniae 08031012 IS/DR, activity value is MIC = 9.4 ug/ml||Anti-K. pneumoniae 08040202 IS/DR, activity value is MIC = 0.6 ug/ml||Anti-K. pneumoniae 08040724 IS/DR, activity value is MIC = 0.3 ug/ml||Anti-Salmonella Typhi IS/DR, activity value is MIC = 1.2 ug/ml||Anti-Saccharibacillus kuerlensis, activity value is MIC = 4.7 ug/ml||Anti-B. pumilus, activity value is MIC = 9.4 ug/ml||Anti-B. cereus, activity value is MIC = 1.2 ug/ml||Anti-S. aureus 08A875 IS/DR, activity value is MIC = 75 ug/ml||Anti-S. aureus 08031002 IS/DR, activity value is MIC > 100 ug/ml||Anti-S. aureus 08031013 IS/DR, activity value is MIC > 100 ug/ml||Anti-S. aureus 08032706 IS/DR, activity value is MIC > 100 ug/ml||Anti-S. aureus 08032712 IS/DR, activity value is MIC > 100 ug/ml||Anti-S. aureus 08032810 IS/DR, activity value is MIC > 100 ug/ml||Anti-Enterococcus faecium IS/DR, activity value is MIC = 150 ug/ml||Anti-Aspergillus nidulans, activity value is MIC = 18.7 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 2.3 uM||Anti-P. aeruginosa ATCC278953, activity value is MIC = 1.2 uM||Anti-and C. albicans, activity value is MIC = 4.7 uM||Antiviral ; Influenza A virus	venom, banded krait, Bungarus fasciatus|||Bungarus fasciatus [banded krait]|||Synthetic construct|||Bungarus fasciatus (Banded krait)|||Bungarus fasciatus [banded krait]|||venom, banded krait, Bungarus fasciatus, Asia|||Synthetic construct|||venom, banded krait, Bungarus fasciatus, Asia	Helix	had little hemolytic activity|||No hemolytic and cytotoxic activity was observed at the dose of up to 400 Âug/ml.|||(PLoS ONE 2008) reported that cathelicidin-BF, isolated from the venom of Bungarus fasciatus, showed no hemolytic activity and did not cause hemoglobin release from human red blood cells even at concentrations as high as 400 µg/ml.|||No hemolytic and cytotoxic activity was observed at the dose of up to 400 Âug/ml.|||Cathelicidin-BF had little hemolytic activity on human red blood cells even with peptide concentrations up to 400000 ug/ml. At the same concentration, cathelicidin-BF was neither cytotoxic for mouse macrophage (RAW264.7) nor for human liver tumor cell (HepG2) (data not shown). Thus, it showed considerable selectivity for microorganisms over mammalian cells in vitro.|||Importantly, it showed low toxicity against human blood cells.	PLoS ONE. 2008 Sep 16;3(9):e3217. Pub-Med|||18795096|||29101873|||PLoS One. 2008 Sep 16;3(9):e3217.||Ref.18795096|||18795096|||PLoS ONE. 2008 Sep 16;3(9):e3217. Pub-Med||Tian Y et al. 2013|||https://pubmed.ncbi.nlm.nih.gov/30447229	30	
FPDB00352	AP01246|||DRAMP03379|||AP01246|||DRAMP03379	"	
FLPKTLRKFFCRIRGGRCAVLNCLGKEEQIGRCSNSGRKCCRKKK"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Chemotactic||Anticancer||Anti-MRSA||Anti-E faecalis ATCC 51299, activity value is MBC = 1.2||Anti-S. enterica serovar Typhimurium ATCC 13311, activity value is MBC = 0.6||Anti-and yeast C. albicans ATCC 24433, activity value is MBC = 1.2 uM||Antimicrobial||Antibacterial	spleen, colon, and tissues of the upper and lower respiratory tract, Mus musculus|||spleen, colon, and tissues of the upper and lower respiratory tract, Mus musculus|||Mus musculus (Mouse)|||spleen, colon, and tissues of the upper and lower respiratory tract, Mus musculus|||Mus musculus (Mouse)	Bridge	N/A	"J Biol Chem. 2008 Feb 29;283(9):5414-9. Pub-Med|||J Biol Chem
. 2008 Feb 29;283(9):5414-9. doi: 10.1074/jbc.M709103200. Epub 2007 Dec 31.|||2008 Feb 29;283(9):5414-9. doi: 10.1074/jbc.M709103200. Epub 2007 Dec 31|||Genome Res. 2004 Oct;14(10B):2121-2127.|||J Biol Chem. 2008 Feb 29;283(9):5414-9. Pub-Med|||Genome Res. 2004 Oct;14(10B):2121-2127.J Biol Chem. 2008 Feb 29;283(9):5414-5419."	45	
FPDB00353	AP01259|||DRAMP03538	RWKIFKKIEKVGQNIRDGIVKAGPAVAVVGQAATI	Anti-Gram-||Antifungal||Anticancer||Anti-Recombinant peptide expressed in is active against E. coli K12D31, activity value is MIC = 12 uM||Anti-P. aeruginosa, activity value is MIC = 20 uM||Anti-Salmonella spp, activity value is MIC = 14||Anti-P. chrysogenum, activity value is MIC = 22 uM||Anti-and G. saubinetii . Tandem repeat expression has reached the high yield of 68 ug/ml . Active against Salmonella spp, activity value is MIC = 14 uM||Antimicrobial||Antibacterial	hemolymph, Chinese silkworm, Bombyx mori|||hemolymph, Chinese silkworm, Bombyx mori|||Bombyx mori (Silk moth)	Helix	N/A	Sci China B 1989; 32:473–480. Pub-Med.|||2005 Oct;45(5):720-3||Li et al., 2007||Zhou et al., 2009||Chen et al., 2010|||Sci China B 1989; 32:473–480. Pub-Med.||Li et al., 2007||Zhou et al., 2009||Chen et al., 2010|||Annu Rev Microbiol. 1987;41:103-126.	35	
FPDB00354	AP01277|||DRAMP00954|||AP01277|||DRAMP00954	"	
KSCCPNTTGRNIYNACRLTGAPRPTCAKLSGCKIISGSTCPSDYPK"	Anti-Gram+ & Gram-||Antifungal||Hemolytic||Anticancer||Antimicrobial||Cytotoxic	the European mistletoe, Viscum album L|||Viscum album (European mistletoe)|||the European mistletoe, Viscum album L|||Viscum album (European mistletoe)	Combine Helix and Beta structure||Combine helix and strand structure	AMINO	Acta Chem Scand. 1968;22(8):2624-42|||Eur J Biochem. 1991 Jun 15;198(3):549-553.|||Acta Chem Scand. 1968;22(8):2624-42|||Eur J Biochem. 1991 Jun 15;198(3):549-553.Acta Chem Scand. 1971;25(6):2048-2054.Biochem J. 2000 Sep 1;350 Pt 2:569-577.	46	
FPDB00355	AP01278	"	
KSCCPNTTGRNIYNTCRFGGGSREVCARISGCKIISASTCPSDYPK"	Anticancer	the European mistletoe, Viscum album L	N/A	N/A	Biol Chem. 1997 Sep;378(9):989-96. PubMed	46	
FPDB00356	AP01279|||DRAMP00952	KSCCPNTTGRNIYNTCRLTGSSRETCAKLSGCKIISASTCPSNYPK	Anticancer||Antimicrobial||Antibacterial||Antifungal||Antiviral	seeds, Viscum album L|||Viscum album (European mistletoe)	Combine Helix and Beta structure||Combine helix and strand structure	No hemolysis information or data found in the reference(s) presented in this entry	Biol Chem. 1997 Sep;378(9):989-96. PubMed|||Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):985-992.|||Plant Mol Biol. 1993 Dec;23(6):1233-1242.	46	
FPDB00357	AP01280	KSCCPNTTGRNIYNTCRFAGGSRERCAKLSGCKIISASTCPSDYPK	Anticancer	the Asiatic Viscum album ssp Coloratum ohwi	Combine Helix and Beta structure	N/A	Biol Chem. 1997 Sep;378(9):989-96. PubMed	46	
FPDB00358	AP01281	KSCCPNTTGRNIYNTCRFGGGSRQVCASLSGCKIISASTCPSDYPK	Anticancer	Viscum album L	Combine Helix and Beta structure	N/A	Biol Chem. 1997 Sep;378(9):989-96. PubMed	46	
FPDB00359	AP01282|||DRAMP00955	KSCCPNTTGRNIYNTCRLGGGSRERCASLSGCKIISASTCPSDYPK	Anticancer||Antimicrobial||Antifungal||Cytotoxic	Viscum album L|||Viscum album (European mistletoe)	Combine Helix and Beta structure||Combine helix and strand structure	N/A	Eur J Biochem. 1991 Jun 15;198(3):549-53|||Eur J Biochem. 1991 Jun 15;198(3):549-553.|||Eur J Biochem. 1991 Jun 15;198(3):549-553.Biochem J. 2003 Aug 15;374(Pt 1):71-78.	46	
FPDB00360	AP01283|||3072|||3078|||3084|||3090|||3096|||DRAMP00240	MRKEFHNVLSSGQLLADKRPARDYNRK	Anti-Gram+ & Gram-||Anticancer||IC50= >70 uM||IC50=>70 uM||Antibacterial||Anti-cancer||Antimicrobial	Streptococcus pneumoniae|||Streptococcus pneumoniae (Gram-negative bacteria)	Helix	At concentrations of 0.19 µM, 0.39 µM, 0.78 µM, 1.56 µM, 3.12 µM, 6.25 µM, and 12.5 µM, the percentage of hemolysis is 0.|||The document mentions that Pep27anal2 has a hemolysis rate of 18% on human red blood cells at a concentration of 12.5 µM, whereas melittin exhibits a hemolysis rate of 100% at the same concentration. Other Pep27 analogs did not show significant hemolytic activity at the tested concentrations (up to 12.5 µM).	Cancer Cell Int. 2005 Jul 11;5:21|||Cancer Cell Int. 2005 Jul 11;5:21.	27	L
FPDB00361	AP01284	KSCCKNTTGRNIYNTCRFAGGSRERCAKLSGCKIISASTCPSDYPK	Anticancer	Viscum coloratum (Kom.) Nakai	Combine Helix and Beta structure	N/A	Yao Xue Xue Bao. 2004 Oct;39(10):813-7. In Chinese	46	
FPDB00362	AP01328|||2925|||2926|||2927|||2928|||2929|||2930|||2931|||2932|||2933|||2934|||2935|||2936|||2937|||2938|||2939|||2940|||2941|||2942|||2943|||2944|||2945|||2946|||2947|||2948|||AP01328|||Epinecidin-1|||DRAMP21241	GFIFHIIKGLFHAGKMIHGLV	Anti-Gram+ & Gram-||Antiviral||Antifungal||Antiparasitic||Anti-MRSA||Anti-inflammatory||anti-sepsis||Wound healing||Anticancer||45% Cytotoxicity at 50 ug/ml||38% Cytotoxicity at 25 ug/ml||75% Cytotoxicity at 50 ug/ml||65% Cytotoxicity at 25 ug/ml||75 % Cytotoxicity at 50 ug/ml||83% Cytotoxicity at 50 ug/ml||77 % Cytotoxicity at 25 ug/ml||82 % Cytotoxicity at 50 ug/ml||85 % Cytotoxicity at 25 ug/ml||42 % Cytotoxicity at 12.5 ug/ml||41 % Cytotoxicity at 6.25 ug/ml||39 % Cytotoxicity at 3.125 ug/ml||90 % Cytotoxicity at 50 ug/ml||95 % Cytotoxicity at 25 ug/ml||45 % Cytotoxicity at 12.5 ug/ml||25 % Cytotoxicity at 6.25 ug/ml||25 % Cytotoxicity at 3.125 ug/ml||95 % Cytotoxicity at 50 ug/ml||96 % Cytotoxicity at 25 ug/ml||46 % Cytotoxicity at 12.5 ug/ml||Anti-ntiviral activity against foot-and-mouth disease virus in vitro, activity value is EC50 = 0.6 ug/ml||Anti-Antiviral activity against foot-and-mouth disease virus in vitro, activity value is EC50 = 0.6 ug/ml||Anti-17570764: Listeria monocytogenes, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-Streptococcus pyogenes, activity value is MIC = 25 ug/ml||Anti-Streptococcus agalactiae, activity value is MIC = 50 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC > 100 ug/ml||Anti-Staphylococcus sp, activity value is MIC = 50 ug/ml||Anti-Staphylococcus xylosus, activity value is MIC = 50 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus subsp, activity value is MIC = 6.25 ug/ml||Anti-Enterobacter aerogenes, activity value is MIC = 50 ug/ml||Anti-Enterobacter cloacae subsp, activity value is MIC = 100 ug/ml||Anti-Vibrio alginolyticus, activity value is MIC = 12.5 ug/ml||Anti-Klebsiella oxytoca, activity value is MIC = 100 ug/ml||Anti-Salinivibrio costicola subsp, activity value is MIC = 12.5 ug/ml||Anti-Vibrio vulni cus, activity value is MIC = 50 ug/ml||Anti-Vibrio harveyi, activity value is MIC = 12.5 ug/ml||Anti-Vibrio vulnicus, activity value is MIC = 12.5 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 60 ug/ml||Anti-Yersinia enterocolitica subsp, activity value is MIC = 100 ug/ml||Anti-Carbapenem-resistant K. pneumoniae Bacterial isolates CRKP-1, activity value is MIC = 8000 ug||Anti-CRKP-2, activity value is MIC = 16000 ug||Anti-CRKP-3, activity value is MIC = 8000 ug||Anti-CRKP-4, activity value is MIC = 8000 ug||Anti-CRKP-5, activity value is MIC = 8000 ug||Anti-CRKP-6, activity value is MIC = 16000 ug||Anti-CRKP-7, activity value is MIC = 8000 ug||Anti-CRKP-8, activity value is MIC = 8000 ug||Anti-CRKP-9, activity value is MIC = 8000 ug||Anti-CRKP-10, activity value is MIC = 4000 ug||Anti-CRKP-11, activity value is MIC = 4000 ug||Anti-CRKP-12, activity value is MIC = 16000 ug||Anti-CRKP-13, activity value is MIC = 16000 ug||Anti-CRKP-14, activity value is MIC = 8000 ug||Anti-CRKP-15, activity value is MIC = 4000 ug||Anti-CRKP-16, activity value is MIC = 8000 ug||Anti-CRKP-17, activity value is MIC = 8000 ug||Anti-CRKP-18, activity value is MIC = 8000 ug||Anti-CRKP-19, activity value is MIC = 8000 ug||Anti-CRKP-20, activity value is MIC = 8000 ug||Anti-CRKP-21, activity value is MIC = 8000 ug||Anti-CRKP-22, activity value is MIC = 16000 ug||Anti-CRKP-23, activity value is MIC = 16000 ug||Anti-Carbapenem-resistant K. aerogenes Bacterial isolates CRKA-1, activity value is MIC = 16000 ug||Anti-CRKA-2, activity value is MIC = 8000 ug||Anti-CRKA-3, activity value is MIC = 4000 ug||Anti-CRKA-4, activity value is MIC = 16000 ug||Anti-CRKA-5, activity value is MIC = 4000 ug||Anti-CRKA-6, activity value is MIC = 16000 ug||Anti-CRKA-7, activity value is MIC = 4000 ug||Anti-CRKA-8, activity value is MIC = 8000 ug||Anti-CRKA-9, activity value is MIC = 16000 ug||Anti-CRKA-10, activity value is MIC = 8000 ug||Anti-CRKA-11, activity value is MIC = 4000 ug||Anti-CRKA-12, activity value is MIC = 8000 ug||Anti-CRKA-13, activity value is MIC = 16000 ug||Anti-CRKA-14, activity value is MIC = 8000 ug||Anti-CRKA-15, activity value is MIC = 8000 ug||Anti-CRKA-16, activity value is MIC = 8000 ug||Anti-CRKA-17, activity value is MIC = 4000 ug||Anti-Carbapenem-resistant P. aeruginosa Bacterial isolates CRPA-1, activity value is MIC = 8000 ug||Anti-CRPA-2, activity value is MIC = 16000 ug||Anti-CRPA-3, activity value is MIC = 8000 ug||Anti-CRPA-4, activity value is MIC = 16000 ug||Anti-CRPA-5, activity value is MIC = 16000 ug||Anti-CRPA-6, activity value is MIC = 8000 ug||Anti-CRPA-7, activity value is MIC = 4000 ug||Anti-CRPA-8, activity value is MIC = 16000 ug||Anti-CRPA-9, activity value is MIC = 8000 ug||Anti-CRPA-10, activity value is MIC = 16000 ug||Anti-CRPA-11, activity value is MIC = 16000 ug||Anti-CRPA-12, activity value is MIC = 16000 ug||Anti-CRPA-13, activity value is MIC = 32000 ug||Anti-Carbapenem-resistant A. baumannii Bacterial isolates CRAB-1, activity value is MIC = 32000 ug||Anti-CRAB-2, activity value is MIC = 32000 ug||Anti-CRAB-3, activity value is MIC = 4000 ug||Anti-CRAB-4, activity value is MIC = 16000 ug||Anti-CRAB-5, activity value is MIC = 32000 ug||Anti-CRAB-6, activity value is MIC = 16000 ug||Anti-CRAB-7, activity value is MIC = 32000 ug||Anti-CRAB-8, activity value is MIC = 8000 ug||Anti-CRAB-9, activity value is MIC = 16000 ug||Anti-Methicillin-resistant S. aureus Bacterial isolates MRSA-1, activity value is MIC = 16000 ug||Anti-MRSA-2, activity value is MIC = 16000 ug||Anti-MRSA-3, activity value is MIC = 32000 ug||Anti-MRSA-4, activity value is MIC = 8000 ug||Anti-MRSA-5, activity value is MIC = 16000 ug||Anti-MRSA-6, activity value is MIC = 8000 ug||Anti-MRSA-7, activity value is MIC = 8000 ug||Anti-MRSA-8, activity value is MIC = 16000 ug||Anti-MRSA-9, activity value is MIC = 32000 ug||Anti-MRSA-10, activity value is MIC = 16000 ug||Anti-MRSA-11, activity value is MIC = 16000 ug||Anti-MRSA-12, activity value is MIC = 16000 ug||Anti-MRSA-13, activity value is MIC = 16000 ug||Anti-MRSA-14, activity value is MIC = 16000 ug||Anti-MRSA-15, activity value is MIC = 16000 ug||Anti-MRSA-16, activity value is MIC = 16000 ug||Anti-MRSA-17, activity value is MIC = 8000 ug||Anti-MRSA-18, activity value is MIC = 16000 ug||Anti-MRSA-19, activity value is MIC = 16000 ug||Anti-MRSA-20, activity value is MIC = 16000 ug||Anti-MRSA-21, activity value is MIC = 16000 ug||Anti-MRSA-22, activity value is MIC = 8000 ug||Anti-Micrococcus luteus, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 50 ug/ml||Anti-Streptococcus agalactiae, activity value is MIC >= 100 ug/ml||Anti-Staphylococcus sp, activity value is MIC = 6.25 ug/ml||Anti-##Gram-negative bacteria : Grouper Vibrio alginolyticus, activity value is MIC = 6.25 ug/ml||Anti-Vibrio harveyi, activity value is MIC = 6.25 ug/ml||Anti-Vibrio vulnificus, activity value is MIC = 50 ug/ml	orange-spotted grouper, Epinephelus coioides|||orange-spotted grouper, Epinephelus coioides|||orange-spotted grouper, Epinephelus coioides|||Epinephelus coioides [orange-spotted grouper]|||Synthetic construct	N/A	gene|||hRBC(100% hemolysis at 156.25 ug/ml)|||[Ref.23598079] 0% hemolysis at 25 ug/ml , 10% hemolysis at 50 ug/ml , 15% hemolysis at 100 ug/ml , 30% hemolysis at 200 ug/ml , 50% hemolysis at 400 ug/ml against sheep red blood cells	DNA Cell Biol. 2007 Jun;26(6):403-13|||DNA Cell Biol. 2007 Jun;26(6):403-13|||30552913, 28882626, 17570764, 35052952||Refer 28882626||Refer Pubmed ID 35052952|||Peptides. 2013 Jun;44:139-48. doi: 10.1016/j.peptides.2013.04.004.||Ref.23598079	21	L
FPDB00363	AP01342|||AP01342|||Cn-AMP1|||DRAMP00929	"	
SVAGRAQGM"	Anti-Gram+ & Gram-||Antifungal||Anticancer||Antibacterial ; Erwinia amylovora ( MIC= >50 uM)||Xanthomonas arboricola pv. Pruni ( MIC= >50 uM)||Xanthonomas axonopodis pv. vesicatoria ( MIC= >50 uM)||Xanthomonas fragariae ( MIC= >50 uM)||Pseudomonas syringae pv. Actinidiae ( MIC= >50 uM)||Pseudomonas syringae pv. syringae ( MIC= >50 uM)||Anti-Bacillus subtilis, activity value is MIC = 76 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 80 ug/ml||Anti-Escherichia coli, activity value is MIC = 82 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 79 ug/ml	green coconut water, Cocos nucifera|||green coconut water, Cocos nucifera|||Cocos nucifera (Coconut palm)	Helix	Horse blood cells(0 ± 0.4% hemolysis at 375 uM)	Peptides. 2009 Apr;30(4):633-7|||Peptides. 2009 Apr;30(4):633-7|||30508634|||Ref.19111587	9	
FPDB00364	AP01343|||AP01343|||Cn-AMP2|||DRAMP00930	"	
TESYFVFSVGM"	Anti-Gram+ & Gram-||Anticancer||Anti-plant pathogens Gram-negative X. arboricola pv. pruni and P. syringae pv. actinidiae, activity value is MIC = 12.5||Anti-Pseudomonas syringae pv. Actinidiae, activity value is MIC = 12.5||Anti-Xanthomonas arboricola pv. Pruni, activity value is MIC = 12.5||Anti-Bacillus subtilis, activity value is MIC = 150 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 170 ug/ml||Anti-Escherichia coli, activity value is MIC = 170 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 169 ug/ml	green coconut water, Cocos nucife|||green coconut water, Cocos nucife|||Synthetic construct|||Cocos nucifera (Coconut palm)	N/A	Horse blood cells(8 ± 2.7% hemolysis at 375 uM)	Peptides. 2009 Apr;30(4):633-7|||Peptides. 2009 Apr;30(4):633-7||Camô C et al. 2019||Prabhu S et al. 2014||Gour et al., 2016|||30508634|||Ref.19111587	11	
FPDB00365	AP01412|||DRAMP01963|||AP01412	"	
FLPAIVGAAAKFLPKIFCAISKKC"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 1.5 uM||Anti-C. albicans, activity value is MIC = 6 uM||Anti-Staphylococcus aureus, activity value is MIC = 1.5 uM||Anti-Escherichia coli, activity value is MIC = 25 uM||Anti-Candida albicans, activity value is MIC = 6 uM	North America, leopard frog, Lithobates blairi|||North America, leopard frog, Lithobates blairi|||Lithobates blairi (plains leopard frog)|||North America, leopard frog, Lithobates blairi	N/A	"The document mentions the following hemolysis-related values:
brevinin-1BLc: The half-maximal hemolytic concentration (LC₅₀) against human erythrocytes is 9 µM, and the LC₅₀ against HepG2 human hepatocellular carcinoma cells is 6 µM. brevinin-1BLa: The LC₅₀ for human red blood cells is 14 µM, and the LC₅₀ for HepG2 cells is 12 µM.
brevinin-1Ya: The LC₅₀ for human red blood cells is 18 µM, and the LC₅₀ for HepG2 cells is 16 µM. brevinin-1Yb: The LC₅₀ for human red blood cells is 16 µM, and the LC₅₀ for HepG2 cells is 11 µM.
brevinin-1Yc: The LC₅₀ for human red blood cells is 13 µM, and the LC₅₀ for HepG2 cells is 14 µM.
ranatuerin-2Ya: The LC₅₀ for human red blood cells is greater than 100 µM, while the LC₅₀ for HepG2 cells is 20 µM.|||In Document 8 (Toxicon 2009), brevinin-1BLa, isolated from the skin secretions of the Plains Leopard Frog (Lithobates blairi), had an LC₅₀ of 14 μM against human red blood cells, and brevinin-1BLc had an LC₅₀ of 9 μM against human red blood cells; brevinin-1Ya, isolated from the skin secretions of the Lowland Leopard Frog (Lithobates yavapaiensis), had an LC₅₀ of 18 μM against human red blood cells, brevinin-1Yb had an LC₅₀ of 16 μM, brevinin-1Yc had an LC₅₀ of 13 μM, and ranatuerin-2Ya had an LC₅₀ greater than 100 μM against human red blood cells.|||[Ref.19254736] LC50=14 uM against human red blood cells"	Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. Epub 2009 Feb 28.|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.||Ref.19254736|||19254736||Ref.19254736|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.	24	
FPDB00366	AP01413|||DRAMP01964|||AP01413|||DRAMP01964	"	
FLPIIAGVAAKVLPKIFCAISKKC"	Anti-Gram+ & Gram-||Antifungal||Hemolytic||Anticancer||Antimicrobial||Antibacterial	North America, leopard frog, Lithobates blairi|||Lithobates blairi (leopard frog)|||North America, leopard frog, Lithobates blairi|||Rana boylii (Foothill yellow-legged frog)	N/A	"The document mentions the following hemolysis-related values:
brevinin-1BLc: The half-maximal hemolytic concentration (LC₅₀) against human erythrocytes is 9 µM, and the LC₅₀ against HepG2 human hepatocellular carcinoma cells is 6 µM. brevinin-1BLa: The LC₅₀ for human red blood cells is 14 µM, and the LC₅₀ for HepG2 cells is 12 µM.
brevinin-1Ya: The LC₅₀ for human red blood cells is 18 µM, and the LC₅₀ for HepG2 cells is 16 µM. brevinin-1Yb: The LC₅₀ for human red blood cells is 16 µM, and the LC₅₀ for HepG2 cells is 11 µM.
brevinin-1Yc: The LC₅₀ for human red blood cells is 13 µM, and the LC₅₀ for HepG2 cells is 14 µM.
ranatuerin-2Ya: The LC₅₀ for human red blood cells is greater than 100 µM, while the LC₅₀ for HepG2 cells is 20 µM."	Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. Epub 2009 Feb 28.|||Toxicon. 2009 Jun;53(7-8):699-705.|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||J Pept Res. 2003 Nov;62(5):207-213.	24	
FPDB00367	AP01414|||AP01414|||Brevinin-1BLc|||DRAMP01965|||Brevinin-1BLc|||AP01414	"	
FLPIIAGIAAKFLPKIFCTISKKC"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 1.5 uM||Anti-C. albicans, activity value is MIC = 3 uM||Antibacterial||Anti-Escherichia coli, activity value is MIC = 25 uM||Anti-Staphylococcus aureus, activity value is MIC = 1.5 uM||Anti-Candida albicans, activity value is MIC = 3 uM	North America, leopard frog, Lithobates blairi|||North America, leopard frog, Lithobates blairi|||Rana blairi [Leopard frog]|||Lithobates blairi (plains leopard frog)|||Lithobates blairi (leopard frog)|||Rana blairi [Leopard frog]|||North America, leopard frog, Lithobates blairi|||North America, leopard frog, Lithobates blairi	N/A	"The document mentions the following hemolysis-related values:
brevinin-1BLc: The half-maximal hemolytic concentration (LC₅₀) against human erythrocytes is 9 µM, and the LC₅₀ against HepG2 human hepatocellular carcinoma cells is 6 µM. brevinin-1BLa: The LC₅₀ for human red blood cells is 14 µM, and the LC₅₀ for HepG2 cells is 12 µM.
brevinin-1Ya: The LC₅₀ for human red blood cells is 18 µM, and the LC₅₀ for HepG2 cells is 16 µM. brevinin-1Yb: The LC₅₀ for human red blood cells is 16 µM, and the LC₅₀ for HepG2 cells is 11 µM.
brevinin-1Yc: The LC₅₀ for human red blood cells is 13 µM, and the LC₅₀ for HepG2 cells is 14 µM.
ranatuerin-2Ya: The LC₅₀ for human red blood cells is greater than 100 µM, while the LC₅₀ for HepG2 cells is 20 µM.|||Human erythrocytes ( LC50 = 9 uM ), HepG2 human hepatoma-derived cells ( LC50 = 6 uM )|||In Document 8 (Toxicon 2009), brevinin-1BLa, isolated from the skin secretions of the Plains Leopard Frog (Lithobates blairi), had an LC₅₀ of 14 μM against human red blood cells, and brevinin-1BLc had an LC₅₀ of 9 μM against human red blood cells; brevinin-1Ya, isolated from the skin secretions of the Lowland Leopard Frog (Lithobates yavapaiensis), had an LC₅₀ of 18 μM against human red blood cells, brevinin-1Yb had an LC₅₀ of 16 μM, brevinin-1Yc had an LC₅₀ of 13 μM, and ranatuerin-2Ya had an LC₅₀ greater than 100 μM against human red blood cells.|||[Ref.19254736] LC50=9 uM against human red blood cells.
[Ref.14531844]Non-hemolytic activity against human erythrocytes|||Human erythrocytes ( LC50 = 9 uM ), HepG2 human hepatoma-derived cells ( LC50 = 6 uM )"	Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. Epub 2009 Feb 28.|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.||Ref.19254736|||19254736||Ref.19254736|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.	24	
FPDB00368	AP01415|||AP01415|||Brevinin-1Ya|||DRAMP01966|||AP01415|||DRAMP01966	"	
FLPVIAGVAANFLPKLFCAISKKC"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 50 uM||Anti-S. aureus, activity value is MIC = 3 uM||Anti-C. albicans, activity value is MIC = 12 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Escherichia coli, activity value is MIC = 50 uM||Anti-Candida albicans, activity value is MIC = 12 uM||Antimicrobial||Anti-Gram+||Anti-Gram-	North America, leopard frog, Lithobates yavapaiensis|||North America, leopard frog, Lithobates yavapaiensis|||Rana blairi [Leopard frog]|||Lithobates yavapaiensis (North America leopard frog)|||North America, leopard frog, Lithobates yavapaiensis|||Lithobates blairi (leopard frog)	N/A	"The document mentions the following hemolysis-related values:
brevinin-1BLc: The half-maximal hemolytic concentration (LC₅₀) against human erythrocytes is 9 µM, and the LC₅₀ against HepG2 human hepatocellular carcinoma cells is 6 µM. brevinin-1BLa: The LC₅₀ for human red blood cells is 14 µM, and the LC₅₀ for HepG2 cells is 12 µM.
brevinin-1Ya: The LC₅₀ for human red blood cells is 18 µM, and the LC₅₀ for HepG2 cells is 16 µM. brevinin-1Yb: The LC₅₀ for human red blood cells is 16 µM, and the LC₅₀ for HepG2 cells is 11 µM.
brevinin-1Yc: The LC₅₀ for human red blood cells is 13 µM, and the LC₅₀ for HepG2 cells is 14 µM.
ranatuerin-2Ya: The LC₅₀ for human red blood cells is greater than 100 µM, while the LC₅₀ for HepG2 cells is 20 µM.|||HepG2 cells ( LC50 = 20 uM ), Human erythrocytes ( LC50 > 100 uM )|||highly hemolytic HC50 18 uM, hemolytic. Updated 7/2020; 7/2021"	Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. Epub 2009 Feb 28.|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.||Ref.19254736|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||Toxicon. 2009 Jun;53(7-8):699-705.|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.	24	
FPDB00369	AP01416|||AP01416|||AP01417|||Brevinin-1Yb|||DRAMP01967|||AP01416|||DRAMP01967	"	
FLPIIAGAAAKVVQKIFCAISKKC"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 3 uM||Anti-C. albicans, activity value is MIC = 3 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Escherichia coli, activity value is MIC = 25 uM||Anti-Candida albicans, activity value is MIC = 3 uM||Antimicrobial||Anti-Gram+||Anti-Gram-	North America, leopard frog, Lithobates yavapaiensis|||North America, leopard frog, Lithobates yavapaiensis|||Rana blairi [Leopard frog]|||Lithobates yavapaiensis (North America leopard frog)|||North America, leopard frog, Lithobates yavapaiensis|||Lithobates yavapaiensis (North America leopard frog)	N/A	"The document mentions the following hemolysis-related values:
brevinin-1BLc: The half-maximal hemolytic concentration (LC₅₀) against human erythrocytes is 9 µM, and the LC₅₀ against HepG2 human hepatocellular carcinoma cells is 6 µM. brevinin-1BLa: The LC₅₀ for human red blood cells is 14 µM, and the LC₅₀ for HepG2 cells is 12 µM.
brevinin-1Ya: The LC₅₀ for human red blood cells is 18 µM, and the LC₅₀ for HepG2 cells is 16 µM. brevinin-1Yb: The LC₅₀ for human red blood cells is 16 µM, and the LC₅₀ for HepG2 cells is 11 µM.
brevinin-1Yc: The LC₅₀ for human red blood cells is 13 µM, and the LC₅₀ for HepG2 cells is 14 µM.
ranatuerin-2Ya: The LC₅₀ for human red blood cells is greater than 100 µM, while the LC₅₀ for HepG2 cells is 20 µM."	Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med|||2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. Epub 2009 Feb 28.|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.||Ref.19254736|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.	24	
FPDB00370	AP01417|||Brevinin-1Yc|||DRAMP01968|||AP01417	"	
FLPIIAGAAAKVVEKIFCAISKKC"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Escherichia coli, activity value is MIC = 100 uM||Anti-Candida albicans, activity value is MIC = 6 uM||Anti-E. coli, activity value is MIC = 100 uM	North America, leopard frog, Lithobates yavapaiensis|||Rana blairi [Leopard frog]|||Lithobates yavapaiensis (North American leopard frog)|||North America, leopard frog, Lithobates yavapaiensis	N/A	In Document 8 (Toxicon 2009), brevinin-1BLa, isolated from the skin secretions of the Plains Leopard Frog (Lithobates blairi), had an LC₅₀ of 14 μM against human red blood cells, and brevinin-1BLc had an LC₅₀ of 9 μM against human red blood cells; brevinin-1Ya, isolated from the skin secretions of the Lowland Leopard Frog (Lithobates yavapaiensis), had an LC₅₀ of 18 μM against human red blood cells, brevinin-1Yb had an LC₅₀ of 16 μM, brevinin-1Yc had an LC₅₀ of 13 μM, and ranatuerin-2Ya had an LC₅₀ greater than 100 μM against human red blood cells.|||[Ref.19254736] LC50=13 uM against human red blood cells	Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.||Ref.19254736|||19254736||Ref.19254736|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.	24	
FPDB00371	AP01418|||AP01418|||Ranatuerin-2Ya|||DRAMP02237	"	
GLMDTIKGVAKTVAASWLDKLKCKITGC"	Anti-Gram+ & Gram-||Anticancer||Anti-E. coli, activity value is MIC = 50 uM||Antibacterial||Anti-Escherichia coli, activity value is MIC = 50 uM||Anti-Staphylococcus aureus, activity value is MIC = 50 uM	North America, leopard frog, Lithobates yavapaiensis|||North America, leopard frog, Lithobates yavapaiensis|||Rana blairi [Leopard frog]	N/A	"weak hemolytic|||The document mentions the following hemolysis-related values:
brevinin-1BLc: The half-maximal hemolytic concentration (LC₅₀) against human erythrocytes is 9 µM, and the LC₅₀ against HepG2 human hepatocellular carcinoma cells is 6 µM. brevinin-1BLa: The LC₅₀ for human red blood cells is 14 µM, and the LC₅₀ for HepG2 cells is 12 µM.
brevinin-1Ya: The LC₅₀ for human red blood cells is 18 µM, and the LC₅₀ for HepG2 cells is 16 µM. brevinin-1Yb: The LC₅₀ for human red blood cells is 16 µM, and the LC₅₀ for HepG2 cells is 11 µM.
brevinin-1Yc: The LC₅₀ for human red blood cells is 13 µM, and the LC₅₀ for HepG2 cells is 14 µM.
ranatuerin-2Ya: The LC₅₀ for human red blood cells is greater than 100 µM, while the LC₅₀ for HepG2 cells is 20 µM.|||In Document 8 (Toxicon 2009), brevinin-1BLa, isolated from the skin secretions of the Plains Leopard Frog (Lithobates blairi), had an LC₅₀ of 14 μM against human red blood cells, and brevinin-1BLc had an LC₅₀ of 9 μM against human red blood cells; brevinin-1Ya, isolated from the skin secretions of the Lowland Leopard Frog (Lithobates yavapaiensis), had an LC₅₀ of 18 μM against human red blood cells, brevinin-1Yb had an LC₅₀ of 16 μM, brevinin-1Yc had an LC₅₀ of 13 μM, and ranatuerin-2Ya had an LC₅₀ greater than 100 μM against human red blood cells."	Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. Epub 2009 Feb 28.|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018||Ref.19254736	28	
FPDB00372	AP01461|||AP01461|||Alyteserin-2a|||DRAMP01082	"	
ILGKLLSTAAGLLSNL"	Anti-Gram+||anti-diabetes||Anticancer||Anti-primarily G+ bacteria such as S. aureus, activity value is MIC = 50 uM||Anti-Escherichia coli, activity value is MIC = 150 uM||Anti-Staphylococcus aureus, activity value is MIC = 50 uM||Anti-S. aureus Sens 8325.4, activity value is MIC = 128 ug/ml||Anti-P. aeruginosa MDR1 B38084, activity value is MIC = 256 ug/ml||Anti-P. aeruginosa MDR2 B31770, activity value is MIC = 256 ug/ml||Anti-E. faecium Sens S1, activity value is MIC = 128 ug/ml||Anti-E. faecium Sens S2, activity value is MIC = 128 ug/ml||Anti-E. faecium VanA R39, activity value is MIC = 64 ug/ml||Anti-E. faecium VanB R44, activity value is MIC = 256 ug/ml||Anti-A. baumannii MDR Bangl 027, activity value is MIC = 256 ug/ml	the European midwife toad, Alytes obstetricans|||the European midwife toad, Alytes obstetricans|||Alytes obstetricans|||Alytes obstetricans (European midwife toad)	Helix||Alpha helix	"weak hemolytic LC50 > 100 uM|||The document mentions the following values related to hemolytic activity: 
D-1CDYa: Half-maximal hemolytic concentration (HC₅₀) for human red blood cells is greater than 450 µM.
brevinin-1CDYa: HC₅₀ for human red blood cells is 180±12 µM.
japonicin-1CDYa: HC₅₀ for human red blood cells is 180±10 µM.
temporin-CDYb: HC₅₀ for human red blood cells is greater than 450 µM.|||Human erythrocytes ( LC50 = 135 uM )|||[Ref:19463738] LC50 = 135 uM against human erthrocytes."	Peptides. 2009 Jun;30(6):1069-73. Pub-Med.|||2009 Jun;30(6):1069-73. doi: 10.1016/j.peptides.2009.03.004. Epub 2009 Mar 24.||Ojo et al., 2013|||19463738|||31102497|||Ref.19463738	16	
FPDB00373	AP01465|||AP01465|||Lasioglossin LL-I|||LL-I|||DRAMP02989	"	
VNWKKVLGKIIKVAK"	Anti-Gram+ & Gram-||Anticancer||Anti-B. subtilis, activity value is MIC = 0.8 uM||Anti-S. aureus, activity value is MIC = 14.3 uM||Anti-P. aeruginosa, activity value is MIC = 15.8 uM||Anti-and E. coli, activity value is MIC = 1.7 uM||Anti-Bacillus subtilis, activity value is MIC = 0.8 uM||Anti-Staphylococcus aureus, activity value is MIC = 14.3 uM||Anti-Escherichia coli, activity value is MIC = 1.7 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 15.8 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	the Eusocial Bee Lasioglossum laticeps|||the Eusocial Bee Lasioglossum laticeps|||Lasioglossum laticeps|||Synthetic construct|||Lasioglossum laticeps (Eusocial Bee)	Helix	"LC50>200 uM|||The document mentions the following hemolysis-related values: LL-I, LL-II, LL-III: at concentrations up to 200 μM, the hemolysis rate on red blood cells is 0% (no hemolytic activity).  
LL-II/3, LL-III/3: after replacing Gly8 with Lys, hemolytic activity slightly increases, but the specific values are not clearly stated.  
LL-III/5 (C-terminal deamidation): no hemolytic activity.  
LL-III/6 (C-terminal esterification): hemolytic activity increases, but no specific HC₅₀ value is given.|||Rat red blood cells (LC50 = >200 uM)"	Chembiochem. 2009 Aug 17;10(12):2089-99. PubMed.|||2009 Aug 17;10(12):2089-99. doi: 10.1002/cbic.200900133.|||19591185|||Chembiochem. 2009 Aug 17;10(12):2089-2099.	15	
FPDB00374	AP01466|||AP01466|||LL-II|||DRAMP02990	VNWKKILGKIIKVAK	Anti-Gram+ & Gram-||Anticancer||Anti-B. subtilis, activity value is MIC = 0.7 uM||Anti-S. aureus, activity value is MIC = 9 uM||Anti-P. aeruginosa, activity value is MIC = 14.4 uM||Anti-and E. coli, activity value is MIC = 1.4 uM||Anti-Bacillus subtilis, activity value is MIC = 0.7 uM||Anti-Staphylococcus aureus, activity value is MIC = 9 uM||Anti-Escherichia coli, activity value is MIC = 1.4 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 14.4 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	the Eusocial Bee Lasioglossum laticeps|||the Eusocial Bee Lasioglossum laticeps|||Synthetic construct|||Lasioglossum laticeps (Eusocial Bee)	Helix	"LC50>200 uM|||The document mentions the following hemolysis-related values: LL-I, LL-II, LL-III: at concentrations up to 200 μM, the hemolysis rate on red blood cells is 0% (no hemolytic activity).  
LL-II/3, LL-III/3: after replacing Gly8 with Lys, hemolytic activity slightly increases, but the specific values are not clearly stated.  
LL-III/5 (C-terminal deamidation): no hemolytic activity.  
LL-III/6 (C-terminal esterification): hemolytic activity increases, but no specific HC₅₀ value is given.|||Rat red blood cells (LC50 = >200 uM)"	Chembiochem. 2009 Aug 17;10(12):2089-99. PubMed.|||2009 Aug 17;10(12):2089-99. doi: 10.1002/cbic.200900133.|||19591185|||Chembiochem. 2009 Aug 17;10(12):2089-2099.	15	
FPDB00375	AP01467|||3495|||3501|||3502|||3519|||3520|||3526|||3527|||3544|||3545|||3551|||3552|||3569|||AP01467|||LL-III|||LL-III/5|||LL-III/6|||Lasioglossin LL-III|||LL-III|||AP01467|||DRAMP02991|||DRAMP18608|||DRAMP18609	"	
VNWKKILGKIIKVVK"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||activity value is IC50 = 4||activity value is IC50 = 12||activity value is IC50 = 3||activity value is IC50 = 5||activity value is IC50 = 18||activity value is IC50 = 25||activity value is IC50 = 13 uM||activity value is IC50 = 9 uM||Anti-B. subtilis, activity value is MIC = 0.7 uM||Anti-S. aureus, activity value is MIC = 3.9 uM||Anti-P. aeruginosa, activity value is MIC = 18.7 uM||Anti-and E. coli, activity value is MIC = 1.4 uM||Anti-B. subtilis, activity value is MIC = 0.8 uM||Anti-S. aureus, activity value is MIC = 14.3 uM||Anti-P. aeruginosa, activity value is MIC = 15.8 uM||Anti-and E. coli, activity value is MIC = 1.7 uM||Anti-Bacillus subtilis, activity value is MIC = 0.7 uM||Anti-Staphylococcus aureus, activity value is MIC = 3.9 uM||Anti-Escherichia coli, activity value is MIC = 1.4 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 18.7 uM||Anti-Bacillus subtilis, activity value is MIC = 1.2 uM||Anti-Staphylococcus aureus, activity value is MIC = 40 uM||Anti-Escherichia coli, activity value is MIC = 3.5 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 40 uM||Anti-Bacillus subtilis, activity value is MIC = 0.5 uM||Anti-Staphylococcus aureus, activity value is MIC = 2.1 uM||Anti-Escherichia coli, activity value is MIC = 1 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 22.5 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 3.5 uM||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 1 uM	the Eusocial Bee Lasioglossum laticeps|||Synthetic construct|||Lasioglossum laticeps [Wild eusocial bee]|||Lasioglossum laticeps [Broad-faced furrow bee]|||venom, the Eusocial Bee Lasioglossum laticeps, Europe|||Lasioglossum laticeps (Eusocial Bee)|||Synthetic construct|||venom, the Eusocial Bee Lasioglossum laticeps, Europe	Helix	"LC50>220 uM|||The document mentions the following hemolysis-related values: LL-I, LL-II, LL-III: at concentrations up to 200 μM, the hemolysis rate on red blood cells is 0% (no hemolytic activity).  
LL-II/3, LL-III/3: after replacing Gly8 with Lys, hemolytic activity slightly increases, but the specific values are not clearly stated.  
LL-III/5 (C-terminal deamidation): no hemolytic activity.  
LL-III/6 (C-terminal esterification): hemolytic activity increases, but no specific HC₅₀ value is given.|||Rat red blood cells (LC50 = >200 uM)|||Rat red blood cells (LC50 = 79.3 uM)|||human erythrocytes (LD50 = 157 uM)|||[Ref.19591185]LC50>200 uM against rat red blood cells|||[Ref.19591185]LC50=79.3 uM against rat red blood cells"	Chembiochem. 2009 Aug 17;10(12):2089-99. PubMed.|||2009 Aug 17;10(12):2089-99. doi: 10.1002/cbic.200900133.||Vrablikova et al., 2017|||19591185|||19591185, 28892177|||30753486|||Chembiochem. 2009 Aug 17;10(12):2089-99. PubMed.||Vrablikova et al., 2017|||Chembiochem. 2009 Aug 17;10(12):2089-2099.|||Chembiochem. 2009 Aug 17;10(12):2089-2114.||Ref.19591185|||Chembiochem. 2009 Aug 17;10(12):2089-2115.||Ref.19591185	15	L
FPDB00376	AP01478	PMPVSQECFETLRGHERILSILRHQNLLKELQDLALQGAKERAHQQ	Antifungal||candidacidal||Anticancer||Anti-and C. tropicalis at a concentration, activity value is MIC < 0.5 uM	Homo sapiens	Helix	N/A	Interdiscip Sci. 2015 Feb 14. in press. Li RF et al., 2015|||Interdiscip Sci. 2015 Feb 14. in press. Li RF et al., 2015||Li RF et al., 2015|||Interdiscip Sci. 2015 Feb 14. in press. Li RF et al., 2015	46	
FPDB00377	AP01512|||AP01512|||Imcroporin	"	
FFSLLPSLIGGLVSAIK"	Anti-Gram+||Anti-MRSA||Hemolytic||Anticancer||Anti-Staphylococcus aureus AB94004, activity value is MIC = 20 ug/ml||Anti-Pseudomonas aeruginosa AB93066, activity value is MIC > 100 ug/ml||Anti-Escherichia coli AB94012, activity value is MIC > 100 ug/ml||Anti-Bacillus thuringiensis AB92037, activity value is MIC = 50 ug/ml||Anti-Bacillus subtilis AB91021, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus AB93113, activity value is MIC = 20 ug/ml||Anti-Penicillin-resistant Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Methicillin-resistant coagulase-negative Staphylococcus, activity value is MIC = 50 ug/ml||Anti-Penicillin-sensitive S. epidermidis, activity value is MIC = 20 ug/ml||Anti-Methicillin-resistant Staphylococcus aureus P1386, activity value is MIC = 50 ug/ml||Anti-Methicillin-resistant Staphylococcus aureus P1374, activity value is MIC = 50 ug/ml	Isometrus maculates|||Isometrus maculates|||Isometrus maculatus	N/A	"low hemolytic|||The values related to hemolysis mentioned in this document refer to the hemolysis rates of human red blood cells at different concentrations of imcroporin, with the specific data as follows:

- When the concentration of imcroporin is 50 µg/ml, the hemolysis rate of human red blood cells is below 50%.

- As the concentration increases (up to a maximum of 100 µg/ml), the hemolysis rate gradually rises, but the document does not provide specific numerical values, only showing the trend through a curve (as shown in Figure 4B).

These data were measured through hemolysis experiments and reflect the hemolytic activity of this antimicrobial peptide on human red blood cells; the higher the concentration, the stronger the hemolytic effect.|||Hemolysis rate <50% at a concentration of 50 µg/ml"	"Antimicrob Agents Chemother. 2009 Aug;53(8):3472-7. PubMed.|||Antimicrob Agents Chemother
. 2009 Aug;53(8):3472-7. doi: 10.1128/AAC.01436-08. Epub 2009 May 18.|||Antimicrob Agents Chemother
. 2009 Aug;53(8):3472-7. doi: 10.1128/AAC.01436-08. Epub 2009 May 18.|||19451300"	17	
FPDB00378	AP01519|||DRAMP04395	"	
AMVGT"	Anti-Gram+ & Gram-||Anticancer||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	earthworm, Eisenia fetida|||Eisenia foetida (Common brandling worm)	N/A	N/A	Eur. J Soil Biol 2007; 43:S217-S134.|||European Journal of Soil Biology, 2007, 43:S127-S134	5	
FPDB00379	AP01521|||AP01521|||Cathelicidin-3.4|||DRAMP03680	"	
RFRLPFRRPPIRIHPPPFYPPFRRFL"	Anti-Gram+ & Gram-||Antifungal||Hemolytic||Anticancer||E.coli||P.aeruginosa||S.aureus||L.monocytogenes||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	goat, Capra hirca|||goat, Capra hirca|||Capra hircus [Goat]|||Capra hircus (Goat)	Rich	"have low hemolytic activity at concentrations from1 to100 uM|||At a concentration of 25 μM, the hemolysis rate of ChBac3.4 on human red blood cells was 2.1±0.3%; 

At a concentration of 50 μM, the hemolysis rate was 5.6±0.8%; 

At a concentration of 100 μM, the hemolysis rate was 10.8±2.8%.|||Has low hemolytic activity towards human RBC"	Int J Pept Ther 2009; 15: 31-42.|||Infect Immun. 1999 Nov;67(11):6221-6224.	26	
FPDB00380	AP01534|||AP01534|||Temporin-SHf|||DRAMP20778|||Temporin-SHf|||AP01534|||DRAMP20778	"	
FFFLSRIF"	Anti-Gram+ & Gram-||Antifungal||Anti-MRSA||Anticancer||Anti-Gram- E. coli ATCC 25922 or ML-35p or D21, activity value is MIC = 25||Anti-E.coli ATCC 35218, activity value is MIC > 200 uM||Anti-P.aeruginosa ATCC 27853, activity value is MIC > 200 uM||Anti-positive S. aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 50 uM||Anti-B. megaterium, activity value is MIC = 3 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 50 uM||Anti-S. cerevisiae, activity value is MIC = 12.5 uM||Anti-fungus A.flavus, activity value is MIC > 200 uM||Anti-and L-infantumamastigotes, activity value is MIC > 60 uM||Anti-but not E.coli K12, activity value is MIC > 100 uM||Anti-S.epidermidis 1457, activity value is MIC > 100 uM||Anti-and B.subtilis 168, activity value is MIC > 100 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 25 uM||Anti-Escherichia coli ATCC 35218, activity value is MIC > 200 uM||Anti-Escherichia coli D21, activity value is MIC = 100 uM||Anti-Escherichia coli ML-35p, activity value is MIC = 30 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 200 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-C. albicans ATCC 90028, activity value is MIC = 50 uM||Anti-A. flavus, activity value is MIC > 200 uM||Anti-E.coli ATCC 25922, activity value is MIC = 25 uM||Anti-E.coli ML-35p, activity value is MIC = 30 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-E.faecalis ATCC 29212, activity value is MIC = 50 uM||Anti-B.megaterium, activity value is MIC = 3 uM||Anti-C.albicans ATCC 90028, activity value is MIC = 50 uM||Anti-C.parapsilosis ATCC 22019, activity value is MIC = 50 uM||Anti-S.cerevisiae, activity value is MIC = 12.5 uM||Anti-A.flavus, activity value is MIC > 200 uM||Anti-Bacillus megaterium, activity value is MIC = 3 uM||Anti-s: Candida albicans ATCC 90028, activity value is MIC = 50 uM||Anti-Fungus, activity value is MIC > 200 uM||Anti-Candida albicans, activity value is MIC > 100 uM||Anti-## Gram-positive bacteria: Staphylococcus aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-## Yeasts: Candida albicans ATCC 90028, activity value is MIC = 50 uM||Anti-## Fungus, activity value is MIC > 200 uM	Sahara Frog, Pelophylax saharicus, Africa|||Pelophylax saharica(Sahara frog)|||Synthetic construct|||Pelophylax saharica|||Pelophylax saharicus|||Sahara Frog, Pelophylax saharicus, Africa|||Pelophylax saharica(Sahara frog)	Helix	"no hemolytic activity|||The values related to hemolysis mentioned in this document are the half-maximal hemolytic concentration (LC_{50}), that is, the peptide concentration that causes 50% hemolysis of human red blood cells. The specific data are as follows:

- Temporin-SHf: LC_{50} for human red blood cells = 200 μM

This value was measured through hemolysis experiments and reflects the hemolytic activity of this antimicrobial peptide on human red blood cells. The relatively high value indicates weak hemolytic activity and is much higher than the minimum inhibitory concentrations for sensitive strains (3–50 μM).|||LC50=200 uM|||Human erythrocytes ( LC50 = 200 uM )|||Human RBCs (LC50 = 200 uM)|||The hemolytic value of Temporin-SHf is LC_{50} = 200 μM (LC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells).|||[Ref.20308076] Temporin-SHf is not cytotoxic against human erythrocytes (LC50 = 200 μm), with a hemolytic activity detected only at peptide concentration far above the MIC values determined for the sensitive strains (3–50 μm)"	"J Biol Chem. 2010 May 28;285(22):16880-92. PubMed|||J Biol Chem
. 2010 May 28;285(22):16880-92. doi: 10.1074/jbc.M109.097204. Epub 2010 Mar 22.|||J Biol Chem
. 2010 May 28;285(22):16880-92. doi: 10.1074/jbc.M109.097204. Epub 2010 Mar 22.|||20308076|||J Biol Chem. 2010 May 28;285(22):16880-92.||Ref.20308076|||https://pubmed.ncbi.nlm.nih.gov/20308076|||https://pubmed.ncbi.nlm.nih.gov/28105725|||J Biol Chem. 2010 May 28;285(22):16880-92. PubMed|||J Biol Chem. 2010 May 28;285(22):16880-92.||Ref.20308076"	8	
FPDB00381	AP01564|||DRAMP03092	"	
ATCDLLSKWNWNHTACAGHCIAKGFKGGYCNDKAVCVCRN"	Anti-Gram+||Anticancer||Active against Gram+ M. luteus. It can cause tumor death in drosophila by binding to exposed phosphatidylserine (PS)  . Updated 4/2017; 7/2019.||Antimicrobial||Antibacterial	fruit fly, Drosophila melanogaster|||fruit fly, Drosophila melanogaster|||Drosophila melanogaster (Fruit fly)	Bridge	N/A	Eur J Biochem. 1994 Apr 1;221(1):201-9|||Eur J Biochem. 1994 Apr 1;221(1):201-9||Parvy et al., 2019|||Eur J Biochem. 1994 Apr 1;221(1):201-219.	40	
FPDB00382	AP00494|||3290|||3291|||3292|||3293|||3294|||3295|||3296|||3297|||3298|||3299|||AP00494|||P18	KWKLFKKIPKFLHLAKKF	Anti-Gram+ & Gram-||Hemolytic||Anticancer||92.2 ± 1.02% cell viability at 10 uM||71.1 ± 2.84% cell viability at 20 uM||50 ± 3.09% cell viability at 40 uM||31.5 ± 1.49% cell viability at 60 uM||13.8 ± 1.44% cell viability at 80 uM||86 ± 0.57% cell viability at 10 uM||63.8 ± 0.8% cell viability at 20 uM||47.5 ± 1.66% cell viability at 40 uM||26.9 ± 0.5% cell viability at 60 uM||6.5 ± 1.07% cell viability at 80 uM||Antibacterial||Antitumor	Sequence reverse, shuffling|||Sequence reverse, shuffling|||Synthetic construct	N/A	N/A	Protein Pept Lett 2002 Oct;9(5):395-402|||Protein Pept Lett 2002 Oct;9(5):395-402|||12005420	18	L
FPDB00383	AP01650|||AP01650|||Crotamine|||DRAMP02511|||AP01650|||DRAMP02511	"	
YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSG"	Anti-Gram+ & Gram-||Antifungal||Antiparasitic||Channel inhibitors||Antimalarial||Hemolytic||Anticancer||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-||Cytotoxic||It's now found to have multiple functions||including cell-penetrating (targeting lysosomes) and antimicrobial activities  . Active against P. falciparum. Crotamine preferentially targets eukaryotic cells over prokaryotic Kv channels.	venom, Crotalus durissus terrificus|||venom, Crotalus durissus terrificus|||Crotalus durissus terrificus [South American rattlesnake]|||Crotalus durissus terrificus (South American rattlesnake)|||venom, Crotalus durissus terrificus, South America|||Crotalus durissus terrificus (South American rattlesnake)|||venom, Crotalus durissus terrificus, South America	Combine Helix and Beta structure||Combine helix and strand structure	N/A	"Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-7. PubMed.|||Proc Natl Acad Sci U S A
. 2009 Sep 1;106(35):14972-7. doi: 10.1073/pnas.0904465106. Epub 2009 Aug 13.|||19706485|||Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-14977.|||Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-7. PubMed.||see ref|||Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-14977. Toxicon. 2005 Dec 1;46(7):759-767. Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):213-215. Toxicon. 1998 Dec;36(12):1927-1937. Mol Pharm. 2012 Feb 6|||Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-7. PubMed."	42	
FPDB00384	AP01774|||AP01774|||Cliotide T1|||CT1|||DRAMP00798	"	
GIPCGESCVFIPCITGAIGCSCKSKVCYRN"	Anti-Gram+ & Gram-||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 1.1 uM||Anti-K. pneumonia, activity value is MIC = 2.7 uM||Anti-and P. aeruginosa, activity value is MIC = 4.7 uM||Anti-Escherichia coli ATCC 700926, activity value is MIC = 1.1 uM||Anti-Klebsiella pneumonia ATCC 13883, activity value is MIC = 2.7 uM||activity value is MIC = 4.7 uM||Anti-Pseudomonas aeruginosa ATCC 39018, activity value is MIC = 2.7 uM||Anti-Klebsiella pneumonia ATCC 13883, activity value is MIC = 4.7 uM||Anti-Escherichia coli ATCC 700926, activity value is MIC = 1.3 uM||Anti-Pseudomonas aeruginosa ATCC 39018, activity value is MIC = 1.9 uM||Anti-Klebsiella pneumonia ATCC 13883, activity value is MIC = 1.5 uM	Clitoria ternatea|||Clitoria ternatea|||Clitoria ternatea [Butterfly pea]|||Clitoria ternatea (Butterfly pea)	N/A	HD50=7.1 uM|||In a study of the hemolytic activity of several cyclic peptides (cliotides T1–T4), melittin, which exhibits strong hemolytic activity in bee venom, was used as a control. The relevant values are as follows: the HD50 of cliotide T1 is 7.1 µM; cliotide T2 shows relatively low hemolytic activity, causing only 18% lysis of red blood cells at 40 µM, with an HD50&gt; 100 µM; the HD50 of cliotide T3 is 13.1 µM; the HD50 of cliotide T4 is 7.5 µM; and the HD50 of melittin is 3.2 µM.|||Human erythrocytes ( HD50 = 7.1 uM )|||Human erythrocytes (HD50 = 7.1 uM)|||[Ref.21596752] HD50 = 8.4 uM against human red blood cells	"J Biol Chem. 2011 Jul 8;286(27):24275-87. PubMed.|||J Biol Chem
. 2011 Jul 8;286(27):24275-87. doi: 10.1074/jbc.M111.229922. Epub 2011 May 19.|||21596752|||Ref.21596752"	30	
FPDB00385	AP01775|||CT2|||DRAMP00796	GEFLKCGESCVQGECYTPGCSCDWPICKKN	Anticancer||Escherichia coli ATCC 700926 (MIC = >100 uM)||Pseudomonas aeruginosa ATCC 39018 (MIC = >100 uM)||Klebsiella pneumonia ATCC 13883 (MIC = >100 uM)||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Clitoria ternatea|||Streptococcus bovis	N/A	HD50>100 uM|||Human erythrocytes (HD50 >100 uM)	J Biol Chem. 2011 Jul 8;286(27):24275-87. PubMed.|||21596752|||Appl Environ Microbiol. 2001 Feb;67(2):569-74.	30	
FPDB00386	AP01776|||CT3|||DRAMP00797	"	
GLPTCGETCTLGTCYVPDCSCSWPICMKN"	Hemolytic||Anticancer||Escherichia coli ATCC 700926 (MIC = >100 uM)||Pseudomonas aeruginosa ATCC 39018 (MIC = >100 uM)||Klebsiella pneumonia ATCC 13883 (MIC = >100 uM)||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Clitoria ternatea|||Staphylococcus warneri RK	N/A	HD50=13.1 uM|||Human erythrocytes (HD50 = 13.1 uM)	J Biol Chem. 2011 Jul 8;286(27):24275-87. PubMed.|||21596752|||Peptides. 2008 Jun;29(6):978-84.	29	
FPDB00387	AP01777|||AP01777|||Cliotide T4, Cyclotide cter-P|||DRAMP00795	"	
GIPCGESCVFIPCITAAIGCSCKSKVCYRN"	Anti-Gram+ & Gram-||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 1.3 uM||Anti-K. pneumonia, activity value is MIC = 1.9 uM||Anti-and P. aeruginosa, activity value is MIC = 1.5 uM||Anti-Escherichia coli ATCC 700926, activity value is MIC = 1 uM||Anti-Klebsiella pneumonia ATCC 13883, activity value is MIC = 5.5 uM||activity value is MIC = 7.5 uM||Anti-Escherichia coli ATCC 700926, activity value is MIC = 1.1 uM||Anti-Pseudomonas aeruginosa ATCC 39018, activity value is MIC = 2.7 uM||Anti-Klebsiella pneumonia ATCC 13883, activity value is MIC = 4.7 uM	Clitoria ternatea|||Clitoria ternatea|||Clitoria ternatea [Butterfly pea]|||Clitoria ternatea (Butterfly pea)	N/A	HD50=8.4 uM|||In a study of the hemolytic activity of several cyclic peptides (cliotides T1–T4), melittin, which exhibits strong hemolytic activity in bee venom, was used as a control. The relevant values are as follows: the HD50 of cliotide T1 is 7.1 µM; cliotide T2 shows relatively low hemolytic activity, causing only 18% lysis of red blood cells at 40 µM, with an HD50&gt; 100 µM; the HD50 of cliotide T3 is 13.1 µM; the HD50 of cliotide T4 is 7.5 µM; and the HD50 of melittin is 3.2 µM.|||Human erythrocytes ( HD50 = 8.4 uM )|||[Ref.21596752] HD50 = 7.1 uM against human red blood cells	"J Biol Chem. 2011 Jul 8;286(27):24275-87. PubMed.|||J Biol Chem
. 2011 Jul 8;286(27):24275-87. doi: 10.1074/jbc.M111.229922. Epub 2011 May 19.|||21596752|||Ref.21596752"	30	
FPDB00388	AP01784|||DRAMP00763	"	
GLPVCGETCAGGTCNTPGCSCSWPICTRN"	Anticancer||Antimicrobial||Antibacterial||Antifungal||Antiviral	Africa, the Ethiopian highlands, Viola abyssinica|||Viola abyssinica (Ethiopian highlands)|||Arabidopsis thaliana (Mouse-ear cress)	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2011 Apr 25;74(4):727-31|||J Nat Prod. 2011 Apr 25;74(4):727-731.	29	
FPDB00389	AP01785|||DRAMP00762	"	
GLPVCGETCFGGTCNTPGCTCDPWPVCTRN"	Anticancer||Antimicrobial||Antibacterial||Antifungal||Antiviral	Africa, the Ethiopian highlands, Viola abyssinica|||Viola abyssinica (Ethiopian highlands)|||Arabidopsis thaliana (Mouse-ear cress)	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2011 Apr 25;74(4):727-31|||J Nat Prod. 2011 Apr 25;74(4):727-731.	30	
FPDB00390	AP01794|||2851|||2852|||2853|||2854|||2875|||2876|||2877|||AP01794|||Temporin-1CEa|||DRAMP31681	"	
FVDLKKIANIINSIF"	Anti-Gram+ & Gram-||Anti-inflammatory||Anticancer||22% Cell viability at 40 uM||61% Cytotoxicity at 40 uM||61% Cell viability at 40 uM||32% Cytotoxicity at 40 uM||70% Cell viability at 20 uM||45% Cell viability at 30 uM||30 % Cell viability at 40 uM||Anti-S. lactis, activity value is MIC = 14.4 uM||Anti-X. arboricola pv. pruni and X. axonopodis pv. vesicatoria, activity value is MIC = 3.1||Anti-Bacillus cereus, activity value is MIC = 14.4 uM||Anti-Lactococcus lactis, activity value is MIC = 14.4 uM||Antimicrobial	Chinese brown frog, skin secretions, Rana chensinensis, China, Asia|||Chinese brown frog, skin secretions, Rana chensinensis, China, Asia|||Synthetic construct|||skin of the Chinese brown frog, Rana chensinensis	Helix	LD50=230 uM|||In the study of the hemolytic activity of peptides synthesized from the skin of Chinese forest frogs, the peptide concentration causing 50% red blood cell hemolysis (LD_{50}) was used as the measurement index, with the relevant values as follows: the LD_{50} of brevinin-1CEa was 48 μM; the LD_{50} of temporin-1CEa was 230 μM; the LD_{50} of temporin-1CEb was 112 μM; the LD_{50} of chensinin-1 was greater than 500 μM.|||Human erythrocytes: LD50=230 uM	"Zoolog Sci. 2009;26(3):220–226. PubMed.|||Zoolog Sci
. 2009 Mar;26(3):220-6. doi: 10.2108/zsj.26.220.||Camó C et al. 2018|||Zoolog Sci. 2009 Mar;26(3):220-6."	15	L
FPDB00391	AP01805|||AP01805|||Cr-ACP1|||DRAMP01064	"	
AWKLFDDGV"	Anti-Gram+ & Gram-||Anticancer||Antibacterial||Anticancer ; Human epidermoid cancer cells (Hep2)||Colon carcinoma cells (HCT15)||Anti-Staphylococcus epidermidis, activity value is MIC = 60 uM||Anti-Bacillus subtilis, activity value is MIC = 30 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 30 uM||Anti-EEscherichia coli strain ATCC 8739, activity value is MIC = 30 uM	seeds, Cycas revoluta|||seeds, Cycas revoluta|||Cycas revoluta (Sago palm)	N/A	[Ref.21882228] Hemocompatibility study revealed the effectiveness of both the peptides where it showed no significant lysis of normal RBC cells compare to positive control (Triton X-100). Cr-ACP1 induced hemolysis of 7% at the conentration of 1000 uM.	"J. Cell Biochem. 2012 Jan;113(1):184-93. doi: 10.1002/jcb.23343. PubMed|||J Cell Biochem
. 2012 Jan;113(1):184-93. doi: 10.1002/jcb.23343.|||21882228|||Ref.21882228"	9	
FPDB00392	AP01806	"	
GLPVCGETCVGGTCNTPGCACSWPVCTRN"	Hemolytic||Anticancer	Viola philippica	Bridge	N/A	Peptides. 2011 Aug;32(8):1719-23. PubMed.	29	
FPDB00393	AP01807	"	
GLPVCGETCVGGTCNTPGCGCSWPVCTRN"	Hemolytic||Anticancer	Viola philippica	Bridge	N/A	Peptides. 2011 Aug;32(8):1719-23. PubMed.	29	
FPDB00394	AP01808	GSIPCGESCVFIPCISSVIGCACKSKVCYKN	Hemolytic||Anticancer	Viola philippica	Bridge	N/A	Peptides. 2011 Aug;32(8):1719-23. PubMed.	31	
FPDB00395	AP01809	"	
GIPCGESCVFIPCISSVIGCSCSSKVCYRN"	Hemolytic||Anticancer	Viola philippica	Bridge	N/A	Peptides. 2011 Aug;32(8):1719-23. PubMed.	30	
FPDB00396	AP01810	"	
GSIPCGESCVFIPCISAVIGCSCSNKVCYKN"	Hemolytic||Anticancer	Viola philippica	Bridge	N/A	Peptides. 2011 Aug;32(8):1719-23. PubMed.	31	
FPDB00397	AP01811	"	
GSIPCGESCVFIPCISAIIGCSCSSKVCYKN"	Hemolytic||Anticancer	Viola philippica	Bridge	N/A	Peptides. 2011 Aug;32(8):1719-23. PubMed.	31	
FPDB00398	AP01812	"	
GSIPCEGSCVFIPCISAIIGCSCSNKVCYKN"	Hemolytic||Anticancer	Viola philippica	Bridge	N/A	Peptides. 2011 Aug;32(8):1719-23. PubMed.	31	
FPDB00399	AP01813	"	
GIPCGESCVFIPCLTSAIDCSCKSKVCYRN"	Hemolytic||Anticancer	Viola philippica	Bridge	N/A	Peptides. 2011 Aug;32(8):1719-23. PubMed.	30	
FPDB00400	AP01922|||3647|||3675|||3690|||3703|||AP01922|||CAMPSQ3627|||DRAMP20779	"	
GMWSKILGHLIR"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||activity value is IC50 > 100 uM||activity value is IC50 = 49||Anti-E. coli, activity value is MIC = 0.8||Anti-and CCRF-CEMT, activity value is IC50 = 11||Antibacterial||Anti-Escherichia coli, activity value is MIC = 3.8 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 45 uM||Anti-## Gram-positive bacteria: Bacillus subtilis, activity value is MIC = 0.8 uM||Anti-Staphylococcus aureus, activity value is MIC = 7.7 uM	venom, the eusocial bee, Halictus sexcinctus|||Synthetic construct|||Halictus sexcinctus|||venom, the eusocial bee, Halictus sexcinctus, Europe, Asia|||Halictus sexcinctus	Helix	Hemolytic activity LC50=82 uM|||venom, the eusocial bee, Halictus sexcinctus||82 µM (for rat red blood cells) (LC50, µM) Note: The hemolytic activity for human red blood cells is 102 µM.|||[Ref.20198492]  LC50=82 uM against rat red blood cells	"Amino Acids. 2010 Aug;39(3):763-75. PubMed.|||Amino Acids. 2010 Aug;39(3):763-75. doi: 10.1007/s00726-010-0519-1. Epub 2010 Mar 3.||Slaninova J et al. 2012 Peptides 33:18-26|||20198492|||Amino Acids
. 2010 Aug;39(3):763-75. doi: 10.1007/s00726-010-0519-1. Epub 2010 Mar 3.||Slaninova J et al. 2012 Peptides 33:18-26|||Amino Acids. 2010 Aug;39(3):763-75.||Ref.20198492|||Amino Acids. 2010 Aug;39(3):763-75. PubMed."	12	L
FPDB00401	AP01923|||3649|||3654|||3677|||3682|||3705|||3710|||AP01923|||CAMPSQ3628|||HAL-2|||AP01923|||DRAMP20780	"	
GKWMSLLKHILK"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||activity value is IC50 = 12||activity value is IC50 = 15||activity value is IC50 = 35||activity value is IC50 > 40 uM||activity value is IC50 = 34 uM||Anti-E. coli, activity value is MIC = 0.8||Anti-and CCRF-CEMT, activity value is IC50 = 12||Antibacterial||Anti-Escherichia coli, activity value is MIC = 2.5 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 42.1||Anti-## Gram-positive bacteria: Bacillus subtilis, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 8.1 uM	venom, the eusocial bee, Halictus sexcinctus|||Halictus sexcinctus|||Synthetic construct|||Synthetic construct|||Halictus sexcinctus [six-banded furrow bee]|||venom, the eusocial bee, Halictus sexcinctus, Europe, Asia|||Halictus sexcinctus|||venom, the eusocial bee, Halictus sexcinctus, Europe, Asia	Helix	Hemolytic activity LC50=78.1 uM|||venom, the eusocial bee, Halictus sexcinctus||78.1 µM (for rat red blood cells) (LC50, µM) Note: The hemolytic activity for human red blood cells is 91 µM.|||human erythrocytes (LD50 = 78 uM)|||[Ref.20198492]  LC50=78.1 uM against rat red blood cells	"Amino Acids. 2010 Aug;39(3):763-75. PubMed.|||Amino Acids. 2010 Aug;39(3):763-75. doi: 10.1007/s00726-010-0519-1. Epub 2010 Mar 3.||Slaninova J et al. 2012 Peptides 33:18-26|||20198492|||28600071|||30753486|||Amino Acids
. 2010 Aug;39(3):763-75. doi: 10.1007/s00726-010-0519-1. Epub 2010 Mar 3.||Slaninova J et al. 2012 Peptides 33:18-26|||Amino Acids. 2010 Aug;39(3):763-75.||Ref.20198492|||Amino Acids. 2010 Aug;39(3):763-75. PubMed."	12	L
FPDB00402	AP01956|||3586|||3591|||3592|||3595|||3596|||3602|||3607|||3608|||3611|||3612|||3618|||3623|||3624|||3627|||3628|||DRAMP20935|||AP01956|||DRAMP20935	"	
GFGMALKLLKKVL"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||activity value is IC50 = 10||activity value is IC50 = 15||activity value is IC50 = 8||activity value is IC50 = 32||activity value is IC50 = 21||activity value is IC50 = 23||activity value is IC50 = 49||activity value is IC50 = 29||activity value is IC50 > 100 uM||activity value is IC50 = 68||activity value is IC50 = 12||activity value is IC50 = 29 uM||activity value is IC50 = 15 uM||activity value is IC50 = 70 uM||activity value is IC50 = 43||Anti-B. subtilis, activity value is MIC = 1.3 uM||Anti-S. aureus, activity value is MIC = 3.7 uM||Anti-L. monocytogenes KCTC 3710, activity value is MIC = 25 uM||Anti-E. coli, activity value is MIC = 3 uM||Anti-P. aeruginosa, activity value is MIC = 6.25||Anti-E. coli, activity value is MIC = 6.25 uM||Anti-and C. albicans, activity value is MIC = 6.3 uM||Anti-Escherichia coli, activity value is MIC = 3 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 35 uM||Anti-Bacillus subtilis, activity value is MIC = 1.3 uM||Anti-Staphylococcus aureus, activity value is MIC = 3.7 uM||Anti-Fungus: Candida albicans, activity value is MIC = 6.3 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 3.13 uM||Anti-Listeria monocytogenes KCTC 3710, activity value is MIC = 25 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 6.25 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.25 uM||Anti-## Gram-positive bacteria: Bacillus subtilis, activity value is MIC = 1.3 uM||Anti-## Fungus: Candida albicans, activity value is MIC = 6.3 uM||Anti-##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 6.25 uM	venom, the solitary bee Macropis fulvipes|||Macropis fulvipes (Solitary bee) (Megilla fulvipes)|||venom, the solitary bee Macropis fulvipes, Europe|||Macropis fulvipes (Solitary bee) (Megilla fulvipes)|||venom, the solitary bee Macropis fulvipes, Europe	Helix||Alpha helix,random coil	"Hemolysis LC50=165 uM|||venom, the solitary bee Macropis fulvipes|||- Test conditions: 4% human red blood cell suspension, incubated at 37°C for 1 hour, detection wavelength 540 nm; blank control (physiological solution only) represents 0% hemolysis, 0.2% Triton X-100 represents 100% hemolysis.

- Natural peptide MAC-1 (macropin): LC_{50} = 160 μM, showing moderate hemolytic activity.

- All-D type analog MAC-1/1: LC_{50} = 152.0 μM, hemolytic activity close to that of the natural peptide.

- Low hemolytic analogs (LC_{50} > 200 μM): MAC-1/7, MAC-1/8, MAC-1/14, MAC-1/15, MAC-1/16, MAC-1/17, MAC-1/13, MAC-1/18, MAC-1/4, MAC-1/19, among which MAC-1/31 has LC_{50} > 800 μM, with extremely low hemolytic activity.

- High hemolytic analogs: MAC-1/3 (LC_{50} = 53.0 μM), MAC-1/24 (LC_{50} = 88 μM), MAC-1/25 (LC_{50} = 88 μM), MAC-1/26 (LC_{50} = 93 μM), with hemolytic activity significantly higher than that of the natural peptide.

- Other key analogs: MAC-1/2 (LC_{50} = 241 μM), MAC-1/9 (LC_{50} = 199 μM), MAC-1/10 (LC_{50} = 476 μM), MAC-1/20 (LC_{50} = 262 μM), MAC-1/27 (LC_{50} = 391 μM), MAC-1/28 (LC_{50} = 120 μM), MAC-1/29 (LC_{50} = 131 μM), MAC-1/30 (LC_{50} = 345 μM).|||The hemolytic activity of hainanenin-1 and 5 was then tested.
But undesirably, the result showed that hainanenin-1 and 5
possessed strong hemolytic activity on human erythrocytes. At con-
centrations of 25 ␮g/ml and 50 ␮g/ml (5–10 times of MICs), the
hemolytic rate of hainanenin-1 was 20.72% and 42.34%, respec-
tively. At the same concentrations, hainanenin-5 exhibited higher
hemolytic rate of 23.31% and 49.16%, respectively.|||[Ref.24616110] LC50=160 uM against human red blood cells. ##[Ref.29185466]5% hemolysis at 25 uM against red blood cells, 93% hemolysis at 50 uM against red blood cells|||HC50 160 uM."	"Peptides. 2012 Jan;33(1):18-26. PubMed.|||Peptides. 2012 Jan;33(1):18-26. doi: 10.1016/j.peptides.2011.11.002. Epub 2011 Nov 7.|||Sci Rep. 2017 Nov 29;7(1):16580. doi: 10.1038/s41598-017-16784-6.||Ref.24616110||Ref.29185466|||Peptides
. 2012 Jan;33(1):18-26. doi: 10.1016/j.peptides.2011.11.002. Epub 2011 Nov 7.|||J Pept Sci. 2014 Jun;20(6):375-84. doi: 10.1002/psc.2625. Epub 2014 Mar 11.## Sci Rep. 2017 Nov 29;7(1):16580. doi: 10.1038/s41598-017-16784-6.||Ref.24616110||Ref.29185466|||Peptides. 2012 Jan;33(1):18-26. PubMed."	13	L
FPDB00403	AP01957|||3587|||3619|||DRAMP31770	GTGLPMSERRKIMLMMR	Anti-Gram+ & Gram-||Antifungal||Anticancer||activity value is IC50 > 100 uM||activity value is IC50 = 32 uM||Antimicrobial	venom, the solitary bee Macropis fulvipes|||venom, the solitary bee Macropis fulvipes, Europe|||Synthetic	N/A	"Hemolysis LC50>200 uM|||venom, the solitary bee Macropis fulvipes|||The hemolytic activity of hainanenin-1 and 5 was then tested.
But undesirably, the result showed that hainanenin-1 and 5
possessed strong hemolytic activity on human erythrocytes. At con-
centrations of 25 ␮g/ml and 50 ␮g/ml (5–10 times of MICs), the
hemolytic rate of hainanenin-1 was 20.72% and 42.34%, respec-
tively. At the same concentrations, hainanenin-5 exhibited higher
hemolytic rate of 23.31% and 49.17%, respectively.|||Human erythrocytes: IC50>200 uM"	"Peptides. 2012 Jan;33(1):18-26. PubMed.|||Peptides. 2012 Jan;33(1):18-26. doi: 10.1016/j.peptides.2011.11.002. Epub 2011 Nov 7.|||Peptides
. 2012 Jan;33(1):18-26. doi: 10.1016/j.peptides.2011.11.002. Epub 2011 Nov 7.|||Peptides. 2012 Jan;33(1):18-26.|||Peptides. 2012 Jan;33(1):18-26. PubMed."	17	L
FPDB00404	AP01964|||AP01964|||Hymenochirin-1B|||Hymenochirin-1B|||AP01964|||DRAMP04654	"	
IKLSPETKDNLKKVLKGAIKGAIAVAKMV"	Anti-Gram+ & Gram-||Antifungal||anti-diabetes||Anticancer||Anti-K. pneumoniae, activity value is MIC = 20||Escherichia coli||Pseudomonas aeruginosa||Klebsiella pneumoniae||Staphylococcus aureus||Candida albicans||Anti-L. rhamnosus LGG, activity value is MIC = 250 ug/ml||Anti-L. casei R0215, activity value is MIC = 250 ug/ml||Anti-L. casei Shirota, activity value is MIC = 32 ug/ml||Anti-S. suis S10, activity value is MIC = 32 ug/ml||Antibacterial||Anti-Cancer cell lines: A549, activity value is IC50 = 15.22||Anti-HCT116, activity value is IC50 = 12.76||Anti-HepG2, activity value is IC50 = 8.07||Anti-S. aureus ATCC 29213, activity value is MIC = 12.5 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-S.epidermidis RP62A, activity value is MIC = 3.1 uM||Anti-S.epidermidis RP62A/1, activity value is MIC = 1.6 uM||Anti-C.albicans ATCC 90028, activity value is MIC = 100 uM||Anti-##Gram-negative bacteria: E.coli, activity value is MIC = 25 uM||Anti-A. baumannii, activity value is MIC = 6.25 uM||Anti-S. maltophilia, activity value is MIC = 6.25 uM||Anti-K. pneumoniae, activity value is MIC = 25 uM||Anti-P. aeruginosa, activity value is MIC = 50 uM||Anti-P.mirabilis, activity value is MIC > 100 uM	Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa|||Hymenochirus boettgeri [Congo dwarf clawed frog]|||Hymenochirus boettgeri|||Hymenochirus boettgeri [Congo dwarf clawed frog]|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa|||Hymenochirus boettgeri (Congo dwarf clawed frog)|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa	α-helical (most likely)	"LC50=225 uM|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa||LC₅₀ = 225 µM (for human red blood cells)|||The abilities of the synthetic hymenochirins to inhibit the
growth of reference strains of the Gram-positive bacterium S.
aureus, the Gram-negative bacteria E. coli, K. pneumoniae, and P.
aeruginosa, and the opportunistic yeast pathogen C. albicans are
compared in Table 1. The MIC values for hymenochirin-5B may be
artefactually high because of the restricted solubility of the peptide
in Mueller-Hinton broth and its tendency to form a gel in con-
centrated solution. All peptides displayed relatively low hemolytic
activities against human erythrocytes (LC50 in the range 160 to
>300 ␮M).|||[Ref.30789695] It has 5%, 6.3%, 7.7%, 10%, 10.7%, 15.3%, 9%, 15% and 9.7% hemolysis against fresh rabbit blood cells at 0.010, 0.25, 0.5, 1.0, 2.0, 5.0, 10.0, 20.0, 25 uM|||[Ref.24172540] LC₅₀ = 213 ± 18 uM against freshly prepared human erythrocytes."	"Peptides. 2012 Jun;35(2):269-75. PubMed.|||Peptides. 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 3.||Owolabi BO et al., 2016||Zhang et al., 2019|||22497805|||31102497|||22497805|||Peptides
. 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 3.||Owolabi BO et al., 2016||Zhang et al., 2019|||ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.||Ref.30789695|||Ref.24172540|||Peptides. 2012 Jun;35(2):269-75. PubMed."	29	
FPDB00405	AP01983|||DRAMP00771	GIACGESCVFLGCFIPGCSCKSKVCYFN	Anticancer||Antimicrobial||Anti-HIV||Anti-cancer	Psychotria leptothyrsa|||Arabidopsis thaliana (Mouse-ear cress)	Bridge	N/A	J Nat Prod. 2010 Jul 23;73(7):1207-13.PubMed|||J Nat Prod. 2010 Jul 23;73(7):1207-1213.	28	
FPDB00406	AP01984	"	
GVIPCGESCVFIPCISSVLGCSCKNKVCYRD"	Anticancer	Psychotria leptothyrsa	Bridge	N/A	J Nat Prod. 2010 Jul 23;73(7):1207-13.PubMed	31	
FPDB00407	AP01985	KLCGETCFKFKCYTPGCSCSYPFCK	Anticancer	Psychotria leptothyrsa	Bridge	N/A	J Nat Prod. 2010 Jul 23;73(7):1207-13.PubMed	25	
FPDB00408	AP01986|||DRAMP00767	"	
GDACGETCFTGICFTAGCSCNPWPTCTRN"	Hemolytic||Anticancer||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	hybrid peptide of melittin and protamine, designed, man-made sequences|||Arabidopsis thaliana (Mouse-ear cress)	Bridge	HD50=51.9 uM	J Biol Chem. 2012 May 18;287(21):17598-607. PubMed|||J Biol Chem. 2012 May 18;287(21):17598-17607.	29	
FPDB00409	AP01987|||DRAMP00768	GIPCAESCVWIPPCTITALMGCSCKNNVCYNN	Anticancer||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chassalia chartacea (or Chassalia curviflora)|||Arabidopsis thaliana (Mouse-ear cress)	Bridge	HD50>25 uM	J Biol Chem. 2012 May 18;287(21):17598-607. PubMed|||J Biol Chem. 2012 May 18;287(21):17598-17607.	32	
FPDB00410	AP01988|||DRAMP00769	"	
GASCGETCFTGICFTAGCSCNPWPTCTRN"	Hemolytic||Anticancer||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chassalia chartacea (or Chassalia curviflora)|||Arabidopsis thaliana (Mouse-ear cress)	Bridge	HD50=51.9 uM	J Biol Chem. 2012 May 18;287(21):17598-607. PubMed|||J Biol Chem. 2012 May 18;287(21):17598-17607.	29	
FPDB00411	AP01989|||AP01989|||ChaC7|||DRAMP00336	"	
IPCGESCVWIPCITAIAGCSCKNKVCYT"	Anti-Gram-||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 6.4 uM||Anti-not active against S-aureus and S-epidermis till 80 uM, activity value is MIC > 80 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.4 uM||Anti-Escherichia coli, activity value is MIC = 6.4 uM||Anti-Staphylococcus aureus, activity value is MIC > 80 uM||Anti-Staphylococcus epidermidis, activity value is MIC > 80 uM	Chassalia chartacea (or Chassalia curviflora)|||Chassalia chartacea	Bridge	HD50=11.6 uM|||Chassalia chartacea (or Chassalia curviflora)|||Human erythrocytes ( HD 50 ( 50% lysis of red blood cells ) = 11.6 uM )	J Biol Chem. 2012 May 18;287(21):17598-607. PubMed|||J Biol Chem. 2012 May 18;287(21):17598-17607. doi: 10.1074/jbc.M111.338970. Epub 2012 Mar 30.|||22467870	28	
FPDB00412	AP01990|||AP01990|||ChaC8|||DRAMP00337	"	
AIPCGESCVWIPCISTVIGCSCSNKVCYR"	Anti-Gram-||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 6.6 uM||Anti-but no activity was detected till 80 uM against S-aureus and S-epidermis, activity value is MIC > 80 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.6 uM||Anti-Escherichia coli, activity value is MIC = 6.6 uM||Anti-Staphylococcus aureus, activity value is MIC > 80 uM||Anti-Staphylococcus epidermidis, activity value is MIC > 80 uM	Chassalia chartacea (or Chassalia curviflora)|||Chassalia chartacea	Bridge	HD50=25.5 uM|||Chassalia chartacea (or Chassalia curviflora)|||Human erythrocytes ( HD 50 ( 50% lysis of red blood cells ) = 25.5 uM )	J Biol Chem. 2012 May 18;287(21):17598-607. PubMed|||J Biol Chem. 2012 May 18;287(21):17598-17607. doi: 10.1074/jbc.M111.338970. Epub 2012 Mar 30.|||22467870	29	
FPDB00413	AP01991|||DRAMP00770	GEYCGESCYLIPCFTPGCYCVSRQCVNKN	Anticancer||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chassalia chartacea (or Chassalia curviflora)|||Arabidopsis thaliana (Mouse-ear cress)	Bridge	HD50>25 uM	J Biol Chem. 2012 May 18;287(21):17598-607. PubMed|||J Biol Chem. 2012 May 18;287(21):17598-17607.	29	
FPDB00414	AP01992|||AP01992|||ChaC11|||DRAMP00338	"	
IPCGESCVWIPCISGMFGCSCKDKVCYS"	Anti-Gram-||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 8.5 uM||Anti-S-aureus, activity value is MIC > 80 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.5 uM||Anti-Escherichia coli, activity value is MIC = 8.5 uM||Anti-Staphylococcus aureus, activity value is MIC > 80 uM||Anti-Staphylococcus epidermidis, activity value is MIC > 80 uM	Chassalia chartacea (or Chassalia curviflora)|||Chassalia chartacea	Bridge	HD50=13.3 uM|||Chassalia chartacea (or Chassalia curviflora)|||Human erythrocytes ( HD 50 ( 50% lysis of red blood cells ) = 13.3 uM )	J Biol Chem. 2012 May 18;287(21):17598-607. PubMed|||J Biol Chem. 2012 May 18;287(21):17598-17607. doi: 10.1074/jbc.M111.338970. Epub 2012 Mar 30.|||22467870	28	
FPDB00415	AP02093	"	
SDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGA"	Anti-Gram+ & Gram-||Chemotactic||Anticancer	Homo sapiens	Combine Helix and Beta structure	N/A	J Leukoc Biol. 2003 Sep;74(3):448-55. Pub-Med. GenBank:CAG29322.1	86	
FPDB00416	AP02111|||DRAMP01447|||AP02111|||DRAMP01447	"	
GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-diabetes||Anticancer||Anti-Bacteria E. coli, activity value is MIC = 5 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 5 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 5 uM||Anti-S. aureus, activity value is MIC = 5 uM||Anti-A. baumannii, activity value is MIC = 5 uM||Anti-and S. maltophilia, activity value is MIC < 10 uM||Anti-E. coli, activity value is MIC = 5 uM||Anti-K. pneumoniae, activity value is MIC = 5 uM||Anti-P. aeruginosa, activity value is MIC = 5 uM	skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America|||skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America|||Lithobates chiricahuensis|||skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America|||Lithobates chiricahuensis	N/A	skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America||At a concentration of 100 μM, the hemolysis rate is < 10%.|||[Ref.21262304] LC50=150 uM against human erythrocytes|||less hemo.lytic (hRBC HC50=150 uM)	"Peptides. 2011 Apr;32(4):664-9. Pub-Med.|||Peptides
. 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.|||Peptides. 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.||Ojo et al., 2015|||Peptides. 2011 Apr;32(4):664-669.|||21262304|||Peptides
. 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.||Ojo et al., 2015|||Gram-negative bacteria: E. coli (MIC=5 uM), K. pneumoniae (MIC=5 uM), P. aeruginosa (MIC=5 uM);
Gram-positive bacterium: S. aureus (MIC=5 uM).
Yeast: C. albicans (MIC=10 uM).|||Peptides. 2011 Apr;32(4):664-9. Pub-Med."	37	
FPDB00417	AP02134|||AP02134|||TP3|||TP3|||DRAMP31547	"	
FIHHIIGGLFSVGKHIHSLIHGH"	Anti-Gram+ & Gram-||Anti-MRSA||Wound healing||Anticancer||Anti-Gram-negative V. vulnificus 204, activity value is MIC = 2.44 ug/ml||Anti-A-hydrophila BCRC 13018, activity value is MIC > 19.55 ug/ml||Anti-V. alginolyticus, activity value is MIC = 2.44 ug/ml||Anti-P-aeruginosa ATCC 19660, activity value is MIC > 19.55 ug/ml||Anti-S. agalactiae 819, activity value is MIC = 9.78 ug/ml||Anti-E. faecalis BCRC 10066, activity value is MIC = 19.55 ug/ml||Antibacterial||Antifungal||Anti-S. aureus, activity value is MIC = 256 ug/ml||Anti-MRSA, activity value is MIC = 256 ug/ml||Anti-C. albicans, activity value is MIC = 128 ug/ml||Antimicrobial||Antiviral	Nile Tilapia, Oreochromis niloticus|||Nile Tilapia, Oreochromis niloticus|||Oreochromis niloticus [Nile tilapia]|||Synthetic construct|||Oreochromis niloticus	N/A	"were hemolytic in fish red blood cells at 100000 ug/ml for 42% hemolysis|||The hemolytic values of five piscidin peptides (TP1-5) from Nile tilapia (Oreochromis niloticus) on fish red blood cells are as follows:

Table

Peptide Name  Concentration (ug/ml)  Hemolysis Rate (%)
TP1           100                     0
TP2           40                      60
TP3           100                     42
TP4           100                     100
TP5           100                     0

Note: TP1 and TP5 showed no hemolytic activity at the highest tested concentration (100 ug/ml); TP2 had a hemolysis rate of 60% at 40 ug/ml; TP3 had a hemolysis rate of 42% at 100 ug/ml; TP4 caused complete hemolysis (100%) at 100 ug/ml. The data are the average of three repeated experiments, and different letters indicate significant differences between groups (p<0.05).|||Nile Tilapia, Oreochromis niloticus||HC₅₀ = 8 uM。|||Vibrio vulnificus 204 ( MIC = 2.44 ug/ml ), Aeromonas hydrophila BCRC 13018 ( MIC >19.55 ug/ml ), Vibrio alginolyticus ( MIC = 2.44 ug/ml ), Pseudomonas aeruginosa ATCC 19660 ( MIC >19.55 ug/ml ), Streptococcus agalactiae 819 ( MIC = 9.78 ug/ml ), E. faecalis BCRC 10066 ( MIC = 19.55 ug/ml ), S. agalactiae BCRC 10787 ( MIC = 0.61 ug/ml )|||Mouse erythrocytes (100% hemolysis, 25 ug/ml)|||Mouse erythrocytes (100% hemolysis, 25 ug/ml)"	"PLoS One. 2012;7(11):e50263. Pub-Med.|||PLoS One
. 2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30.|||PLoS One. 2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30.|||23226256|||29040295|||29040295|||Peptides. 2018 Aug;106:91-95."	23	
FPDB00418	AP02135|||AP02135|||TP4|||DRAMP018494|||TP4|||AP02135	"	
FIHHIIGGLFSAGKAIHRLIRRRRR"	Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis||Hemolytic||Wound healing||Anticancer||Anti-Gram-negative V. vulnificus 204, activity value is MIC = 0.03 ug/ml||Anti-A. hydrophila BCRC 13018, activity value is MIC = 1.05 ug/ml||Anti-V. alginolyticus, activity value is MIC = 0.03 ug/ml||Anti-P. aeruginosa ATCC 19660, activity value is MIC = 0.52 ug/ml||Anti-S. agalactiae 819, activity value is MIC = 2.1 ug/ml||Anti-E. faecalis BCRC 10066, activity value is MIC = 8.39 ug/ml||Anti-which is active against S. aureus, activity value is MIC = 5 uM||Anti-B. subtilis, activity value is MIC = 1.7 uM||Anti-E. tarda, activity value is MIC = 20 uM||Anti-Vibrio vulnificus 204, activity value is MIC = 0.03 ug/ml||Anti-Aeromonas hydrophila BCRC 13018, activity value is MIC = 1.05 ug/ml||Anti-Vibrio alginolyticus, activity value is MIC = 0.03 ug/ml||Anti-Pseudomonas aeruginosa ATCC 19660, activity value is MIC = 0.52 ug/ml||Anti-Streptococcus agalactiae 819, activity value is MIC = 2.1 ug/ml||Anti-S. agalactiae BCRC 10787, activity value is MIC = 0.13 ug/ml||Anti-P. aeruginosa, activity value is MIC = 64 ug/ml||Anti-S. aureus, activity value is MIC = 8 ug/ml||Anti-MRSA, activity value is MIC = 16 ug/ml||Anti-C. albicans, activity value is MIC = 128 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||activity value is MBC = 16 ug/ml||Anti-Methicillin-resistant Staphylococcus aureus, activity value is MIC = 16 ug/ml||activity value is MBC = 32 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 64 ug/ml||activity value is MBC = 128 ug/ml||Anti-Candida albicans, activity value is MIC = 128 ug/ml	gills, Nile Tilapia, Oreochromis niloticus|||gills, Nile Tilapia, Oreochromis niloticus|||Oreochromis niloticus [Nile tilapia]|||Oreochromis niloticus|||Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)|||Oreochromis niloticus|||gills, Nile Tilapia, Oreochromis niloticus	Helix||Alpha helix	"were hemolytic in fish red blood cells at 100000 ug/ml for 100% hemolysis|||TP1 and TP5 showed no hemolytic activity at a concentration of 100 µg/ml. TP2 had a hemolysis rate of 60% at a concentration of 40 µg/ml. TP3 had a hemolysis rate of 42% at a concentration of 100 µg/ml. TP4 had a hemolysis rate of 100% at a concentration of 100 µg/ml.|||gills, Nile Tilapia, Oreochromis niloticus||HC₅₀ = 5 uM。|||Mouse erythrocytes (100% hemolysis, 25 ug/ml)|||Mouse erythrocytes (100% hemolysis, 25 ug/ml)|||. TP4 presented excellent antimicrobial
activity compared to cod pis 1 and grouper epinecidin-1.
Furthermore, the TP1,5 synthetic peptides were assayed for
hemolytic activities in fish blood cells. The TP1 and TP5 synthetic
peptides showed no hemolytic activity, and even when treated with
100000 ug/ml peptide, no hemolytic activity was detected (Fig. 5). In
contrast, TP4 and TP3 were hemolytic in fish red blood cells at
100000 ug/ml for 100% hemolysis and 42% hemolysis, respectively
(Fig. 5). TP2 achieved 60% hemolysis at 40000 ug/ml.|||fish RBCs, HC50 50 ug/ml, moderate hemolytic."	"PLoS One. 2012;7(11):e50263. Pub-Med.|||2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30.||Kuo et al., 2018||Ting CH et al., 2016|||PLoS One. 2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30.||Kuo et al., 2018||Ting CH et al., 2016|||23226256|||29040295|||PLoS One. 2017 Oct 17;12(10):e0186442.||Ref.29040295|||29040295|||PLoS One
. 2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30||Kuo et al., 2018||Ting CH et al., 2016|||PLoS One. 2012;7(11):e50263. Pub-Med."	25	
FPDB00419	AP02136|||AP02136|||Gaduscidin-1	"	
FIHHIIGWISHGVRAIHRAIH"	Anti-Gram+ & Gram-||Synergistic AMPs||Antibiofilm||Anticancer||Anti-and P. immobilisc NCIMB 308, activity value is MIC = 0.3||Antibacterial	Atlantic cod, Gadus morhua L.|||Gadus morhua|||Atlantic cod, Gadus morhua L.	Helix	"Atlantic cod, Gadus morhua L.||HC₅₀ = 12 uM。|||Escherichia coli MG1655[MIC = 2 uM], Escherichia coli MG1655[MIC = 4 uM], Escherichia coli MG1655[MIC = 16 uM], Escherichia coli MG1655[MBC = 2 uM], Escherichia coli MG1655[MBC = 16 uM], Vibrio harveyi[MIC = 8 uM], Vibrio harveyi[MBC = 16 uM], Aeromonas hydrophila[MIC = 16 uM], Aeromonas hydrophila[MBC = 16 uM], Pseudomonas aeruginosa PAO1[MIC >128 uM], Pseudomonas aeruginosa PAO1[MIC = 16 uM], Pseudomonas aeruginosa PAO1[MIC = 64 uM], Pseudomonas aeruginosa PAO1[MIC = 2 uM], Pseudomonas aeruginosa PAO1[MIC = NA ], Pseudomonas aeruginosa PAO1|||This document explicitly mentions the hemolytic values of three piscidin-related synthetic peptides (Pis1, Pis2, Pis2-β) from Atlantic cod (Gadus morhua L.), with melittin and cecropin P1 used as controls. The specific data are as follows:

1. Core hemolytic data (against Atlantic cod red blood cells)

The hemolysis of all tested peptides was measured by incubation at 37°C for 30 minutes. 0.2% Triton X-100 was used as the 100% hemolysis positive control, and PBS was used as the 0% hemolysis negative control. Results are expressed as the percentage of hemolysis relative to the positive control:

Pis1, Pis2, Pis2-β: At the highest tested concentration (1.6 μM), the hemolysis rate was all below 10%. Within the concentration range of 0.2 to 1.6 μM, the hemolysis rate remained consistently low (<10%), similar to the non-hemolytic control peptide cecropin P1.
Control peptides:
Melittin (hemolytic positive control): Hemolysis rate at 0.2 μM was 19.5%, and at 1.6 μM reached 78.7%, significantly higher than the three piscidin peptides.
Cecropin P1 (non-hemolytic control): Hemolysis rates were similar to Pis1, Pis2, Pis2-β, all <10% (at 1.6 μM).

2. Key conclusions

The hemolytic activity of the three cod piscidin peptides against their own red blood cells is extremely low. Even at concentrations far exceeding their antibacterial/anti-parasitic activity (e.g., 1.6 μM, much higher than the minimum inhibitory concentrations (MICs) for some bacteria, 0.04–10 μM), they caused almost no hemolysis.

Comparison with their bioactivity: Pis1 has antibacterial MICs as low as 0.04–10 μM. The anti-parasitic concentrations (PC₁₀₀) of Pis1, Pis2, Pis2-β are 5–9.9 μM, all below the concentration that induces significant hemolysis (>1.6 μM still shows no significant hemolysis), indicating that these peptides have good cellular selectivity (strong toxicity to microbes, weak toxicity to host red blood cells)."	Fish Shellfish Immunol. 2012 Mar;32(3):396-406. Pub-Med.|||Fish Shellfish Immunol. 2012 Mar;32(3):396-406. doi: 10.1016/j.fsi.2011.11.022. Epub 2011 Dec 8.|||33770667, 33428273|||Fish Shellfish Immunol. 2012 Mar;32(3):396-406. Pub-Med.	21	
FPDB00420	AP02137|||DRAMP34939	"	
FLHHIVGLIHHGLSLFGDRAD"	Anti-Gram-||Anticancer||Anti-Gram-negative bacteria Y. ruckeric NCIMB 2196 and P. immobilisc NCIMB 308, activity value is MIC = 2.5||Antimicrobial	Atlantic cod, Gadus morhua L.|||Gadus morhua	Helix	Atlantic cod, Gadus morhua L.||HC₅₀ = 35 uM。	Fish Shellfish Immunol. 2012 Mar;32(3):396-406. Pub-Med.|||Fish Shellfish Immunol. 2012 Mar;32(3):396-406. doi: 10.1016/j.fsi.2011.11.022. Epub 2011 Dec 8.||McDonald M et al., 2015|||Fish Shellfish Immunol. 2012 Mar;32(3):396-406.	21	
FPDB00421	AP02141|||1670|||1674|||1678|||1682|||1686|||1690|||1694|||1698|||1702|||DRAMP31797	"	
LLRHVVKILEKYL"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||57.62 Inhibition ratio at 50 ug/ml||52.77 Inhibition ratio at 50 ug/ml||52.32 Inhibition ratio at 50 ug/ml||50.90 Inhibition ratio at 50 ug/ml||48.19 Inhibition ratio at 50 ug/ml||45.62 Inhibition ratio at 50 ug/ml||37.22 Inhibition ratio at 50 ug/ml||30.82 Inhibition ratio at 50 ug/ml||24.15Inhibition ratio at 50 ug/ml||predicted to be helical.||Anti-S. aureus ATCC 25923, activity value is MIC = 2.5 ug/ml||Anti-S. suis 2 CVCC 606, activity value is MIC = 15.6 ug/ml||Anti-C. albicans ATCC10231, activity value is MIC = 31.25 ug/ml||Anti-Salmonella ATCC 20020, activity value is MIC = 15.6 ug/ml||Anti-P. aeruginosa ATCC 227853, activity value is MIC = 60 ug/ml||Anti-B-subtitlis, activity value is MIC > 64 uM||Anti-M. luteus, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 8 uM||Anti-P. vulgaris, activity value is MIC = 16 uM||Antimicrobial	Skin,The American bullfrog, Lithobates Catesbeianus, North America|||Skin,The American bullfrog, Lithobates Catesbeianus, North America|||Temporins family	N/A	showed no measurable hemolytic activity against rabbit erythrocytes at 250 ug/ml|||Skin,The American bullfrog, Lithobates Catesbeianus, North America||At a concentration of 50 µM, the hemolysis rate exceeds 50%.|||Showed no hemolytic activity against rabbit erythrocytes and human erythrocytes at 250 ug/ml	Molecular Cloning – Selected Applications in Medicine and Biology 2011 Sci Direct.|||Molecular Cloning – Selected Applications in Medicine and Biology 2011|||Molecular Cloning – Selected Applications in Medicine and Biology 2011 Sci Direct.|||J Pept Sci. 2012 Jul;18(7):476-86.	13	L
FPDB00422	AP02142	"	
GFLDIIKDTGKEFAVKILNNLKCKLAGGCPP"	Anti-Gram+ & Gram-||Anticancer||Anti-Listeria ATCC 54004, activity value is MIC = 30||Anti-S. aureus ATCC 25923, activity value is MIC = 7.8 ug/ml||Anti-P. aeruginosa ATCC 227853, activity value is MIC = 60 ug/ml	Skin,The American bullfrog, Lithobates Catesbeianus, North America	Helix	showed little hemolytic activity (0.25% at 250 ug/ml)|||Skin,The American bullfrog, Lithobates Catesbeianus, North America||At a concentration of 100 μM, the hemolysis rate is < 10%.	Molecular Cloning – Selected Applications in Medicine and Biology 2011	31	
FPDB00423	AP02151|||AP02151|||C18G	"	
ALYKKLLKKLLKSAKKLG"	Anti-Gram-||Anticancer||Anti-Gram- E. coli . Active against E. coli, activity value is MIC = 1.875 uM||Anti-P. aeruginosa, activity value is MIC = 7.5 uM||Anti-A. baumannii, activity value is MIC = 1.875 uM||Anti-S. aureus, activity value is MIC = 1.875 uM||Anti-and B. subtilis, activity value is MIC = 1.875 uM||Anti-E. coli, activity value is MIC = 940 uM||Anti-S. aureus, activity value is MIC = 1880 uM||Anti-S. enterica, activity value is MIC = 1880 uM||Anti-P. aeruginosa, activity value is MIC = 1880 uM||Anti-S. epidermidis, activity value is MIC = 940 uM	derivative of the carboxyl terminus of human platelet factor IV, animal-derived, natural derivative|||Synthetic construct	Helix	derivative of the carboxyl terminus of human platelet factor IV, animal-derived, natural derivative	J Clin Invest. 1992 Aug;90(2):447-55. doi: 10.1172/JCI115880. Pub-Med.|||J Clin Invest. 1992 Aug;90(2):447-55. doi: 10.1172/JCI115880.||ref||Kohn et al., 2018||Peck-Miller et al., 1993|||29103131	18	
FPDB00424	AP02216|||AP02216|||Amphiphatic peptide CT1|||Amphiphatic peptide CT1|||DRAMP03714	"	
FLGALWNVAKSVF"	Anti-Gram+ & Gram-||Anticancer||Anti-S. aureus ATCC 25923, activity value is MIC = 10 uM||Anti-B. subtilis ATCC 6633, activity value is MIC = 20 uM||Anti-E. coli ATCC 25922, activity value is MIC = 20 uM||Anti-S. typhi ATCC 6399, activity value is MIC = 10 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 10 uM||Anti-and S. agalactiae, activity value is MIC = 20 uM||Anti-S.aureus, activity value is MIC = 10 uM||Anti-B.subtilis, activity value is MIC = 20 uM||Anti-S.agalactiae, activity value is MIC = 20 uM||Anti-E.coli, activity value is MIC = 25 uM||Anti-S.typhi, activity value is MIC = 5 uM||Anti-and P.aeruginosa, activity value is MIC = 10 uM||Antibacterial||Antifungal||Antiprotozoal||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 3.12 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 25 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 3.12 uM||Anti-##Gram-negative bacterium: Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 0.78 uM||Anti-Escherichia coli D31, activity value is MIC = 3.12 uM||Anti-Serratia marcescens ATCC 4112, activity value is MIC = 1.56 uM||Anti-Enterobacter cloacae β-12, activity value is MIC = 25 uM||Anti-Micrococcus luteus A270, activity value is MIC = 1.56 uM||Anti-##Fungi: Candida albicans MDM8, activity value is MIC = 12.5 uM||Anti-Candida tropicalis IOC 4560, activity value is MIC = 6.25 uM||Anti-Candida parapsilosis IOC 4564, activity value is MIC = 25 uM||Anti-Aspergillus niger, activity value is MIC = 25 uM||Anti-Cladosporium herbarum ATCC 26362, activity value is MIC = 50 uM||Anti-Cryptococcus neoformans, activity value is MIC = 3.12 uM	Vaejovis mexicanus smithi|||Vaejovis mexicanus smithi [Scorpion]|||Vaejovis mexicanus smithi (Scorpion)	Helix||Alpha helix, random coil	mildly hemolytic|||Vaejovis mexicanus smithi||The hemolytic activity is extremely low, with a hemolysis rate of only 6% at the maximum concentration of 50 uM.The hemolysis rate is 12% at 50 uM, and it is even lower within its minimum inhibitory concentration (MIC) range (5–25 uM).|||Human erythrocytes 12% lysis (50 uM); [Refer PubMed ID - 31181304: Human RBCs [Hemolysis observed in the concentration of 0.1–100 uM] ]|||Human erythrocytes 12% lysis (50 uM); [Refer PubMed ID - 31181304: Human RBCs [Hemolysis observed in the concentration of 0.1�100 uM] ]|||[Ref.27912176] 10% hemolysis at 1.99 uM against human red blood cells.	Peptides. 2012 Apr;34(2):290-5. Pub-Med.|||Peptides. 2012 Apr;34(2):290-5. Pub-Med.||Pedron et al. 2017|||22342498, 31212183, 33442881,31181304|||22342498, 31212183, 33442881,31181304|||Eur J Med Chem. 2017 Jan 27;126:456-463.||Ref.27912176	13	
FPDB00425	AP02228	"	
RKGWFKAMKSIAKFIAKEKLKEHL"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anticancer||Anti-Gram-Negative Bacteria E. coli CGMCC1.1369, activity value is MIC = 25 uM||Anti-E. cloacae CGMCC1.58, activity value is MIC = 50 uM||Anti-Positive E. faecalis CGMCC1.100, activity value is MIC = 25 uM||Anti-B. thuringiensis Israel H14, activity value is MIC = 12.5 uM||Anti-B. cereus CMCC1.126, activity value is MIC = 6.2 uM||Anti-T. halophilus CGMCC1.2492, activity value is MIC = 3.1 uM||Anti-A. flavus CGMCC3.6433, activity value is MIC = 3.1 uM||Anti-B. bassiana CGMCC3.3576, activity value is MIC = 6.2 uM||Anti-and S. cerevisiae CGMCC2.1619, activity value is MIC = 50 uM	Venom, Lycosa singoriensis|||Venom, Lycosa singoriensis, Europe	Helix	Venom, Lycosa singoriensis|||10% hemolysis at 100 uM	"Curr Mol Med. 2012 Dec;12(10):1350-60. Pub-Med.|||Curr Mol Med. 2012 Dec;12(10):1350-60. Pub-Med.||Tang et al., 2019|||Curr Mol Med
. 2012 Dec;12(10):1350-60. doi: 10.2174/156652412803833643.||Tang et al., 2019|||Curr Mol Med. 2012 Dec;12(10):1350-60. Pub-Med."	24	
FPDB00426	AP02234|||3130|||3131|||3132|||3133|||3134|||DRAMP21244|||AP02234|||DRAMP21244	"	
FLSLIPKLVKKIIKAFK"	Anti-Gram+ & Gram-||Antifungal||Hemolytic||Anticancer||activity value is IC50 = 1.5 uM||activity value is IC50 = 1.6 uM||activity value is IC50 = 1.8 uM||activity value is IC50 = 2.1 uM||activity value is IC50 = 2.9 uM||Anti-Staphylococcus aureus, activity value is MIC = 2.5 uM||Anti-Escherichia coli, activity value is MIC = 5 uM||Anti-Candida albicans, activity value is MIC = 2.5 uM||activity value is MBC = 20 uM||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 5 uM||Anti-##Fungi : Candida albicans, activity value is MIC = 2.5 uM||activity value is MBC = 5 uM	The inactive natural peptide TsAP-1 was made active by increasing 4 lysines and one leucine, template-based design|||Synthetic construct|||The inactive natural peptide TsAP-1 was made active by increasing 4 lysines and one leucine, template-based design|||Synthetic construct	Alpha helix	"The inactive natural peptide TsAP-1 was made active by increasing 4 lysines and one leucine, template-based design||The hemolysis rate is 28% at 5 uM; concentrations of 20 uM and above cause complete hemolysis.|||- TsAP-1: At 160 µM, the hemolysis rate is only 6.48%, indicating low hemolytic activity.

- TsAP-2: No hemolysis at ≤15 µM; 86% hemolysis at 40 µM; complete hemolysis (100%) at ≥80 µM.

- TsAP-S1: 28% hemolysis at 5 µM; complete hemolysis (100%) at ≥20 µM.

- TsAP-S2: 28% hemolysis at 5 µM; complete hemolysis (100%) at ≥20 µM.|||[Ref.23770440] 30% hemolysis at 5 uM , 85% hemolysis at 10 uM , 100% hemolysis at 20 uM against horse red blood cells|||not hemolytic at 15 uM, but it caused 50% hemolysis (HC50 at ~30 uM and 100% hemolysis at 80 uM (Hemolytic)."	"Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. Pub-Med.|||Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. Pub-Med.|||Biochimie. 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003.||Ref.23770440|||Biochimie
. 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003. Epub 2013 Jun 14.|||Biochimie. 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003.||Ref.23770440"	17	L
FPDB00427	AP02235|||3125|||3126|||3127|||3128|||3129|||AP02235|||Putative antimicrobial peptide clone 4|||Antimicrobial peptide TsAP-2|||NDBP-4.23|||DRAMP03688|||Antimicrobial peptide TsAP-2|||NDBP-4.23|||AP02235	"	
FLGMIPGLIGGLISAFK"	Anti-Gram+||Antifungal||candidacidal||Hemolytic||Antibiofilm||Anticancer||activity value is IC50 = 4.1 uM||activity value is IC50 = 11 uM||activity value is IC50 = 6.4 uM||activity value is IC50 = 13.3 uM||activity value is IC50 = 15.4 uM||Anti-S. aureus, activity value is MIC = 5 uM||activity value is MBC = 10 uM||Anti-E.coli, activity value is MIC > 320 uM||Anti-C. tropicalis ATCC 750, activity value is MIC = 6.25 uM||Anti-C. parapsilosis ATCC22019, activity value is MIC = 100 uM||Anti-C. neoformans H99 serotype A, activity value is MIC = 25 uM||Anti-and C. neoformans B3501 serotype D, activity value is MIC = 12.5 uM||Anti-S.aureus, activity value is MIC = 5 uM||Anti-C.albicans, activity value is MIC = 10 uM||Anti-C. albicans SC5314, activity value is MIC = 50 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 100 uM||Anti-C. glabrata ATCC 90030, activity value is MIC > 400 uM||Anti-C. neoformans B3501 serotype D, activity value is MIC = 12.5 uM||Wound healing||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 15.6 ug/ml||Anti-B. cereus ATCC 11778, activity value is MIC = 31.2 ug/ml||Anti-K.pneumoniae ATCC 23357, activity value is MIC = 250 ug/ml||Anti-S.Typhimurium ATCC14028, activity value is MIC > 250 ug/ml||Anti-C.freundii ATCC 8090, activity value is MIC > 250 ug/ml||Anti-and E.coli EPEC CDC O86:H35, activity value is MIC = 125 ug/ml	venom, the Brazilian yellow scorpion, Tityus serrulatus, also Turrilites costatus; Tityus obscurus, South America|||Tityus costatus|||T. costatus|||venom, the Brazilian yellow scorpion, Tityus serrulatus, also Turrilites costatus; Tityus obscurus, South America|||Vespa magnifica|||venom, the Brazilian yellow scorpion, Tityus serrulatus, also Turrilites costatus; Tityus obscurus, South America	Helix	"venom, the Brazilian yellow scorpion, Tityus serrulatus, also Turrilites costatus; Tityus obscurus, South America||No obvious hemolysis is observed at low concentrations (≤15 uM); the hemolysis rate reaches 86% at 40 uM; and concentrations of 80 uM and above cause complete hemolysis.|||Exhibits hemolysis against human erythrocytes|||The document explicitly measured the hemolytic values of four peptides (TsAP-1, TsAP-2, and their cation-enhanced analogs TsAP-S1, TsAP-S2) on horse red blood cells. The peptides were incubated with a 4% horse red blood cell suspension for 120 minutes. 1% Triton X-100 was used as a 100% hemolysis positive control, and PBS as the 0% hemolysis negative control. The specific data are as follows:

1. Hemolytic activity of natural peptides (TsAP-1, TsAP-2)

TsAP-1: Hemolytic activity was extremely low, only observed at the highest tested concentration (160 µM), with a hemolysis rate of 6.48%; at lower concentrations, the hemolysis rate was negligible.
TsAP-2: Hemolytic activity was concentration-dependent:
Concentration ≤15 µM: No hemolysis (0%).
Concentration = 20 µM: Hemolysis rate 18%.
Concentration = 40 µM: Hemolysis rate significantly increased to 86%.
Concentration ≥80 µM: Complete hemolysis (100%).

2. Hemolytic activity of cation-enhanced analogs (TsAP-S1, TsAP-S2)

Due to increased cationicity, both analogs exhibited significantly higher hemolytic activity than the natural peptides and showed similar concentration-dependent characteristics:

Concentration = 5 µM: Both caused notable hemolysis, with a hemolysis rate of approximately 28%-30%.
Concentration ≥20 µM: Both achieved complete hemolysis (100%).

3. Supplementary related conclusions

Hemolytic activity is positively correlated with cationicity and helicity: the natural peptides (TsAP-1, TsAP-2) have a net charge of 2 and low hemolytic activity; the analogs (TsAP-S1, TsAP-S2) have a net charge increased to 6 and α-helix content increased from 58.82%-76.47% to 88.24%, with significantly enhanced hemolytic activity.
Safety differences: TsAP-1, due to its extremely low hemolytic activity, is safer for antimicrobial applications; while TsAP-2 and the two analogs have stronger antibacterial/antitumor activity, the risk of hemolysis at high concentrations may limit their systemic application, making them more suitable for local use.|||Exhibits hemolysis against human erythrocytes|||not hemolytic at 15 uM, but it caused 50% hemolysis (HC50 at ~30 uM and 100% hemolysis at 80 uM (Hemolytic)."	"Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. Pub-Med.|||Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. Pub-Med.||Guilhelmelli F et al., 2016|||Q5G8B5|||23770440|||27917162|||Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. Pub-Med.|||Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8.|||23770440|||27917162|||Biochimie
. 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003. Epub 2013 Jun 14.||see ref for structure||Guilhelmelli F et al., 2016"	17	L
FPDB00428	AP02253|||AP02253|||Chensinin-1b|||DRAMP20841	"	
SKVWRHWRRFWHRAHRLH"	Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis||Wound healing||Anticancer||Anti-S. aureus, activity value is MIC = 3.13 uM||Anti-S. epidermidis MRSE1208, activity value is MIC = 12.5 uM||Anti-B. cereus, activity value is MIC = 3.13 uM||Anti-S. lactis, activity value is MIC = 3.13 uM||Anti-E. faecalis, activity value is MIC = 1.56 uM||Anti-E. faecium, activity value is MIC = 3.13 uM||Anti-E. coli, activity value is MIC = 6.25 uM||Anti-E-cloacae, activity value is MIC > 50 uM||Anti-P-fluorescens MRPF0322, activity value is MIC > 50 uM||Anti-and P. aeruginosa, activity value is MIC = 1.56 uM||Anti-E. coli MREC0203, activity value is MIC = 1.56 uM||Anti-S. aureus MRSA0910, activity value is MIC = 3.13 uM||Anti-E. faecium M, activity value is MIC = 6.25 uM||Anti-Escherichia coli, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 1.56 uM||Anti-##Gram-positive bacteria:Staphylococcus aureus, activity value is MIC = 3.13 uM	amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct	Helix||Random coil conformation	no hemolytic activity|||All truncated Chensinin-1b analogs exhibited 50% hemolysis concentrations (HC₅₀) &gt;500 µM against human erythrocytes across the concentration range of 0.25–500 µM, indicating no significant hemolytic activity.|||amino acid substitution, amphibians, animal-derived, natural derivative||No obvious hemolytic activity was observed within the concentration range of 0.25–500 uM.|||[Ref.27060618] HC50>500 uM against human red blood cells	Acta Biomater. 2016 Jun;37:59-68. doi: 10.1016/j.actbio.2016.04.003. Pub-Med.|||2016 Jun:37:59-68. doi: 10.1016/j.actbio.2016.04.003. Epub 2016 Apr 6.|||Acta Biomater. 2016 Jun;37:59-68. doi: 10.1016/j.actbio.2016.04.003. Pub-Med.||Li et al., 2023|||28756209|||Acta Biomater. 2016 Jun;37:59-68.||Ref.27060618	18	
FPDB00429	1118|||DRAMP32359	gigkflkkakkfakafvkiinn	activity value is IC50 = 6 uM||Antimicrobial||Anticancer	African clawed frog Xenopus laevis skin	N/A	N/A	Cancer Res. 1993 Jul 1;53(13):3052-7.	22	D
FPDB00430	3505|||3530|||3555|||LLIII-D|||DRAMP31781	vnwkkilgkiikvvk	activity value is IC50 = 6||activity value is IC50 = 20 uM||activity value is IC50 = 5||Antifungal||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Rat erythrocytes: IC50>200 uM	28892177|||Peptides. 2012 Jan;33(1):18-26.	15	D
FPDB00431	3514|||3539|||3564|||DRAMP31785	vnwkkllgkllkvvk	activity value is IC50 = 4||activity value is IC50 = 20 uM||activity value is IC50 = 4 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	15	D
FPDB00432	3588|||3604|||3620|||DRAMP31754	gfgmalkllkkvl	activity value is IC50 = 12||activity value is IC50 = 19||activity value is IC50 = 11 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human erythrocytes: IC50=152 uM	Peptides. 2012 Jan;33(1):18-26.	13	D
FPDB00433	3635|||3663|||3691|||DRAMP32899	gmwskilghlir	activity value is IC50 = 15||activity value is IC50 > 40 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	D
FPDB00434	3650|||3678|||3706|||DRAMP32887	gkwmsllkhilk	activity value is IC50 = 12 uM||activity value is IC50 > 100 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	D
FPDB00435	4039|||4040|||4041|||4042|||4043|||4044|||4045|||4046|||4047|||DRAMP31589	glfdvikkvasviggl	activity value is IC50 = 5000000 uM||Antimicrobial||Anticancer	Amphibian skin secretions	N/A	N/A	Eur J Biochem. 2003 Mar;270(6):1141-53.	16	D
FPDB00436	1002|||1010|||1018|||1026|||1034|||Gaegurin 6|||DRAMP31603	LLAGLAANFLPTIICKISYKC	IC50= >100 ug/ml||IC50=>100 ug/ml||Antibacterial||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Human embryonic kidney HEK293T cells (IC50 at >100 ug/ml|||Human RBCs: less than 6% hemolysis at 100 ug/ml	14499271|||Peptides. 2003 Jul;24(7):945-53.	21	L
FPDB00437	1003|||1011|||1019|||1027|||1035|||Gaegurin 6|||DRAMP31604	FAGLAANFLPTIICKISYKC	IC50=>100 ug/ml||Anti-Human lung carcinoma A549, activity value is IC50 > 100 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 > 100 ug/ml||Anti-Human hepatocellular carcinoma Hep 3B, activity value is IC50 > 100 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is IC50 > 100 ug/ml||Anti-Escherichia coli DH5alpha, activity value is MIC > 100 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028, activity value is MIC > 100 ug/ml||Anti-Klebsiella pneumoniae ATCC 10031, activity value is MIC > 100 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Human RBCs: less than 6% hemolysis at 100 ug/ml	14499271|||Peptides. 2003 Jul;24(7):945-53.	20	L
FPDB00438	1004|||1012|||1020|||1028|||1036|||Gaegurin 6|||DRAMP31605	FLKLLKKLAAKFLPTIICKISYKC	activity value is IC50 = 13.71 ug/ml||activity value is IC50 = 26.15 ug/ml||activity value is IC50 = 18.63 ug/ml||activity value is IC50 = 18.18 ug/ml||activity value is IC50 = 18.1 ug/ml||Antibacterial||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Human embryonic kidney HEK293T cells (IC50 at 26.15+-6.23 ug/ml|||Human RBCs: 45.17% hemolysis at 100 ug/ml	14499271|||Peptides. 2003 Jul;24(7):945-53.	24	L
FPDB00439	1005|||1006|||1013|||1014|||1021|||1022|||1029|||1030|||1037|||1038|||CAMPSQ20046	FLKLLKKLAAKLF	activity value is IC50 = 9.09 ug/ml||activity value is IC50 = 13.94 ug/ml||activity value is IC50 = 15.11 ug/ml||activity value is IC50 = 14 ug/ml||activity value is IC50 = 13.27 ug/ml||activity value is IC50 = 15.07 ug/ml||activity value is IC50 = 5.43 ug/ml||activity value is IC50 = 17.56 ug/ml||Anti-Human lung carcinoma A549, activity value is IC50 = 13.94||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 13.27||Anti-Human hepatocellular carcinoma Hep 3B, activity value is IC50 = 15.07||Anti-Human breast adenocarcinoma MCF-7, activity value is IC50 = 17.56||Anti-Escherichia coli DH5alpha, activity value is MIC = 6.25 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028, activity value is MIC = 25 ug/ml||Anti-Klebsiella pneumoniae ATCC 10031, activity value is MIC = 25 ug/ml	Synthetic construct	N/A	Human embryonic kidney HEK293T cells (IC50 at 14.00+-1.46 ug/ml	14499271	13	L
FPDB00440	1007|||1015|||1023|||1031|||1039|||DRAMP31607	FLGALFKALSKLL	activity value is IC50 = 8.01 ug/ml||activity value is IC50 = 6.71 ug/ml||activity value is IC50 = 5.01 ug/ml||activity value is IC50 = 5.4 ug/ml||activity value is IC50 = 5.25 ug/ml||Antimicrobial||Anticancer	Synthetic	N/A	Human RBCs: less than 6% hemolysis at 100 ug/ml	Peptides. 2003 Jul;24(7):945-53.	13	L
FPDB00441	1008|||1016|||1024|||1032|||1040|||CAMPSQ20047|||DRAMP31608|||DRAMP31611	FLKLLAGLLKNFA	activity value is IC50 = 24.58 ug/ml||activity value is IC50 = 26.8 ug/ml||activity value is IC50 = 28.9 ug/ml||activity value is IC50 = 30.79 ug/ml||activity value is IC50 = 32.23 ug/ml||Anti-Human lung carcinoma A549, activity value is IC50 = 24.58||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 28.90||Anti-Human hepatocellular carcinoma Hep 3B, activity value is IC50 = 30.79||Anti-Human breast adenocarcinoma MCF-7, activity value is IC50 = 32.23||Anti-Escherichia coli DH5alpha, activity value is MIC = 100 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028, activity value is MIC > 100 ug/ml||Anti-Klebsiella pneumoniae ATCC 10031, activity value is MIC = 50 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Synthetic|||hCAP18 Synthetic	N/A	Human embryonic kidney HEK293T cells (IC50 at 26.80+-5.52 ug/ml|||Human RBCs: less than 6% hemolysis at 100 ug/ml	14499271|||Peptides. 2003 Jul;24(7):945-53.|||Cancer Lett. 2004 Aug 30;212(2):185-94.	13	L
FPDB00442	1041|||1042|||1043|||1044|||1045|||1046|||1356|||1362|||1368|||1374|||1380|||1386|||1392|||1398|||1404|||1410|||DRAMP31602	AIGKFLHSAKKFGKAFVGEIMNS	activity value is IC50 = 7.28 uM||activity value is IC50 = 11.7 uM||activity value is IC50 = 6.23 uM||activity value is IC50 = 10.4 uM||activity value is IC50 = 9.7 uM||activity value is IC50 = 6.56 uM||activity value is IC50 = 16 ug/ml||activity value is IC50 = 18 ug/ml||activity value is IC50 = 23 ug/ml||activity value is IC50 = 30 ug/ml||activity value is IC50 = 34 ug/ml||activity value is IC50 = 20 ug/ml||activity value is IC50 = 40 ug/ml||activity value is IC50 = 45 ug/ml||activity value is IC50 = 49 ug/ml||activity value is IC50 = 53 ug/ml||Antimicrobial||Anticancer	African clawed frog Xenopus laevis skin	N/A	Detectable but low hemolytic activity	Cancer Res. 1992 Jul 1;52(13):3534-8.	23	L
FPDB00443	1047|||1048|||1049|||1050|||1051|||1052|||1355|||1361|||1367|||1373|||1379|||1385|||1391|||1397|||1403|||1409|||Magainin-2	GIGKFLHSAKKFAKAFVAEIMNS	activity value is IC50 = 12.5 uM||activity value is IC50 = 10.5 uM||activity value is IC50 = 4.44 uM||activity value is IC50 = 7.23 uM||activity value is IC50 = 11.7 uM||activity value is IC50 = 6.57 uM||activity value is IC50 = 19 ug/ml||activity value is IC50 = 16 ug/ml||activity value is IC50 = 29 ug/ml||activity value is IC50 = 38 ug/ml||activity value is IC50 = 33 ug/ml||activity value is IC50 = 25 ug/ml||activity value is IC50 = 37 ug/ml||activity value is IC50 = 39 ug/ml||activity value is IC50 = 42 ug/ml||activity value is IC50 = 47 ug/ml||Antibacterial	Synthetic construct	N/A	Escherichia coli ATCC 25922[MIC50 = 1.2 ug/ml], Escherichia coli ATCC 25922[MIC = 5 ug/ml], Klebsiella pneumoniae ATCC 13883[MIC50 = 5 ug/ml], Klebsiella pneumoniae ATCC 13883[MIC = 25 ug/ml], Pseudomonas aeruginosa ATCC 27853[MIC50 = 25 ug/ml], Pseudomonas aeruginosa ATCC 27853[MIC = 50 ug/ml], Streptococcus agalactiae ATCC 12386[MIC50 = 0.25 ug/ml], Streptococcus agalactiae ATCC 12386[MIC = 1 ug/ml], Enterococcus faecalis ATCC 29212[MIC50 = 10 ug/ml], Enterococcus faecalis ATCC 29212[MIC = 25 ug/ml], Staphylococcus aureus ATCC 29213[MIC50 = 5 ug/ml], Staphylococcus aureus ATCC 29213[MIC = 10 ug/ml], Staphylococcus aureus ATCC 25923[MIC50 = 10 ug/ml], Staphylococcus aureus ATCC 25923[MIC = 25 ug/ml], Escherichia coli ATCC 25922[MIC50 = 70 ug/ml], Escherichia coli ATCC 25922[MIC >100 ug/ml], Klebsiella pneumoniae ATCC 13883[MIC50 = 100 ug/ml], Klebsiella pneumoniae ATCC 13883[MIC >100 ug/ml], Pseudomonas aeruginosa ATCC 27853[MIC50 = 100 ug/ml], Pseudomonas aeruginosa ATCC 27853[MIC >100 ug/ml], Streptococcus agalactiae ATCC 12386[MIC50 = 100 ug/ml], Streptococcus agalactiae ATCC 12386[MIC >100 ug/ml], Enterococcus faecalis ATCC 29212[MIC50 >100 ug/ml], Enterococcus faecalis ATCC 29212[MIC >100 ug/ml], Staphylococcus aureus ATCC 29213[MIC50 >100 ug/ml], Staphylococcus aureus ATCC 29213[MIC >100 ug/ml], Staphylococcus aureus ATCC 25923[MIC50 >100 ug/ml], Staphylococcus aureus ATCC 25923[MIC >100 ug/ml]	3410055	23	L
FPDB00444	1053|||1054|||1055|||1056|||1057|||1058|||1059|||1060|||1061|||1062|||1063|||1064|||1065|||1066|||1067|||1068|||1069|||1070|||1071|||1072|||1073|||1074|||1075|||1076|||1077|||1078|||1079|||1080|||1081|||1082|||1083|||1084|||1085|||1086|||1087|||1088|||1089|||1090|||1091|||1092|||1093|||1094|||1095|||1096|||1097|||1098|||1099|||1100|||1101|||1102|||1103|||1104|||1105|||1106|||1107|||1108|||1109|||1110|||Buforin IIb|||DRAMP04347	RAGLQFPVGRLLRRLLRRLLR	activity value is IC50 = 14.7 ug/ml||activity value is IC50 = 11.3 ug/ml||activity value is IC50 = 8.2 ug/ml||activity value is IC50 = 17 ug/ml||activity value is IC50 = 10.5 ug/ml||activity value is IC50 = 20.2 ug/ml||activity value is IC50 = 15.1 ug/ml||activity value is IC50 = 11.5 ug/ml||activity value is IC50 = 11.7 ug/ml||activity value is IC50 = 10.6 ug/ml||activity value is IC50 = 12.9 ug/ml||activity value is IC50 = 23.9 ug/ml||activity value is IC50 = 12.1 ug/ml||activity value is IC50 = 12.6 ug/ml||activity value is IC50 = 7.2 ug/ml||activity value is IC50 = 13.3 ug/ml||activity value is IC50 = 10.8 ug/ml||activity value is IC50 = 10.7 ug/ml||activity value is IC50 = 11.2 ug/ml||activity value is IC50 = 12.4 ug/ml||activity value is IC50 = 9.5 ug/ml||activity value is IC50 = 13.8 ug/ml||activity value is IC50 = 15.5 ug/ml||activity value is IC50 = 10.9 ug/ml||activity value is IC50 = 11.1 ug/ml||activity value is IC50 = 8.9 ug/ml||activity value is IC50 = 12.5 ug/ml||activity value is IC50 = 12.2 ug/ml||activity value is IC50 = 10 ug/ml||activity value is IC50 = 12 ug/ml||activity value is IC50 = 14.1 ug/ml||activity value is IC50 = 11 ug/ml||activity value is IC50 = 11.4 ug/ml||activity value is IC50 = 13.1 ug/ml||activity value is IC50 = 9 ug/ml||activity value is IC50 = 15.2 ug/ml||activity value is IC50 = 17.6 ug/ml||activity value is IC50 = 13 ug/ml||activity value is IC50 = 14.6 ug/ml||activity value is IC50 = 13.2 ug/ml||activity value is IC50 = 12.7 ug/ml||activity value is IC50 = 15.3 ug/ml||Anti-Escherichia coli, activity value is MIC = 1 ug/ml||Anti-S. enteritidis, activity value is MIC = 2 ug/ml||Anti-P. putida, activity value is MIC = 2 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 1 ug/ml||Anti-S. mutans, activity value is MIC = 2 ug/ml||Anti-S.aureus, activity value is MIC = 2 ug/ml||Anti-Candida albicans, activity value is MIC = 1 ug/ml||Anti-C.neoformans, activity value is MIC = 2 ug/ml||Anti-S. cerevisiae, activity value is MIC = 2 ug/ml||Antimicrobial||Antibacterial	Synthetic construct	N/A	Human RBC (MHC = 100 ug/ml)	22306477|||Peptides. 2012 Apr;34(2):283-289.	21	L
FPDB00445	1111|||1113|||1114|||1115|||Lfcin1	FKCRRWQWRMKKLGA	activity value is IC50 = 15.5 uM||activity value is IC50 = 37 uM||activity value is IC50 = 45 uM||activity value is IC50 = 60 uM||Anti-Escherichia coli CVCC195, activity value is MIC = 16 uM||Anti-E. coli CVCC1515, activity value is MIC = 16 uM||Anti-E. coli CICC21530, activity value is MIC = 32 uM||Anti-Salmonella typhimurium ATCC14028, activity value is MIC = 16 uM||Anti-S. enteritidis CVCC3377, activity value is MIC = 8 uM||Anti-S. pullorum CVCC1789, activity value is MIC > 64 uM||Anti-S. pullorum CVCC1802, activity value is MIC > 64 uM||Anti-S. choleraesuis CV, activity value is CC50 = 3||Anti-Pseudomonas aeruginosa CICC10419, activity value is MIC > 64 uM||Anti-P. aeruginosa CICC21630, activity value is MIC > 64 uM||Anti-Staphylococcus aureus ATCC43300, activity value is MIC > 64 uM||Anti-S. aureus ATCC25923, activity value is MIC = 1 uM||Anti-Streptococcus suis CVCC606, activity value is MIC > 64 uM||Anti-Enterococcus faecium CMCC1.2136, activity value is MIC = 8 uM||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 32 uM||Anti-34209722: C. albicans S5314, activity value is MIC = 6.25 ug/ml||Anti-C. albicans YLO12, activity value is MIC = 6.25 ug/ml||Anti-C. albicans YH050001, activity value is MIC = 6.25 ug/ml||Anti-C. albicans YH050005, activity value is MIC = 12.5 ug/ml||Anti-C. albicans YH050072, activity value is MIC = 6.25 ug/ml||Anti-C. glabrata YH050105, activity value is MIC = 50 ug/ml||Anti-C. krusei YLO6, activity value is MIC = 12.5 ug/ml||Anti-C. krusei YH050075, activity value is MIC = 6.25 ug/ml||Anti-C. tropicalis YLO86, activity value is MIC = 3.125 ug/ml||Anti-C. tropicalis YH050007, activity value is MIC = 3.125 ug/ml||Anti-C. tropicalis YH050013, activity value is MIC = 6.25 ug/ml||Anti-C. tropicalis YH050114, activity value is MIC = 6.25 ug/ml||Anti-C. parapsilosis YLO7, activity value is MIC = 3.125 ug/ml||Anti-C. dubliniensis YH050092, activity value is MIC = 12.5 ug/ml||Anti-11095180: Escherichia coli ATCC 25922, activity value is MIC = 24 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 48 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 4 ug/ml||Antibacterial||Antifungal	Bos taurus|||Bos taurus [Bovine]	N/A	7.5% hemolysis of mouse RBC at 256??g/ml	28287172, 34209722, 11095180, 30043322||Refer PubMed ID: 30043322|||28287172, 34209722, 11095180, 30043322	15	L
FPDB00446	1117|||DRAMP32358	GIGKFLKKAKKFAKAFVKIINN	activity value is IC50 = 10 uM||Antimicrobial||Anticancer	African clawed frog Xenopus laevis skin	N/A	N/A	Cancer Res. 1993 Jul 1;53(13):3052-7.	22	L
FPDB00447	1119|||1141|||1163|||1187|||1191|||1195|||1199|||Chain A, Cecropin A|||DRAMP03915|||DRAMP03964	KWKLFKKIPKFLHSAKKF	activity value is IC50 = 6 uM||activity value is IC50 = 20 uM||activity value is IC50 = 25 uM||activity value is IC50 = 35.1 uM||activity value is IC50 = 28 uM||Antibacterial||Antimicrobial||Antifungal	Synthetic construct [ ]|||Synthetic construct (De novo design)|||Synthetic construct	N/A	N/A	11009597|||Int J Mol Sci. 2012; 13(11): 15042-15053.|||Biochemistry. 2000 Oct 3;39(39):11855-11864.	18	L
FPDB00448	1120|||1142|||1164|||P18|||DRAMP31569	KWKFKKIPKFLHLAKKF	activity value is IC50 = 8 uM||activity value is IC50 = 4 uM||activity value is IC50 = 3.5 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 1.56 uM||Anti-Proteus vulgaris, activity value is MIC = 3.125 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 1.56 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 0.78 uM||Antimicrobial||Anticancer	Synthetic construct|||Ceropin A	N/A	No hemolysis, Human RBC|||Human erythrocytes: hemolysis: 0%=100 uM; hemolysis: 0%=50 uM; hemolysis: 0%=25 uM; hemolysis: 0%=12.5 uM; hemolysis: 0%=6.25 uM; hemolysis: 0%=3.125 uM; hemolysis: 0%=1.56 uM; hemolysis: 0%=0.78 uM	12005420|||J Pept Res. 2001 Dec;58(6):504-14.	17	L
FPDB00449	1121|||1143|||1165	KWKLFKKILKFLHLAKKF	activity value is IC50 = 3 uM||activity value is IC50 = 9 uM	N/A	N/A	N/A	N/A	18	L
FPDB00450	1122|||1144|||1166	KWKLFKKISKFLHLAKKF	activity value is IC50 = 4 uM||activity value is IC50 = 7 uM||activity value is IC50 = 3 uM	N/A	N/A	N/A	N/A	18	L
FPDB00451	1123|||1145|||1167|||N-1	WKLFKKIPKFLHLAKKF	activity value is IC50 = 9.5 uM||activity value is IC50 = 12 uM||activity value is IC50 = 6 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 1.56 uM||Anti-Proteus vulgaris, activity value is MIC = 1.56 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 1.56 uM	Synthetic construct	N/A	Human RBC (10.1% hemolysis at 100 ug/ml)	12005420	17	L
FPDB00452	1124|||1146|||1168|||N-2	FKLFKKIPKFLHLAKKF	activity value is IC50 = 11 uM||activity value is IC50 = 7 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 1.56 uM||Anti-Proteus vulgaris, activity value is MIC = 1.56 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 0.78 uM	Synthetic construct	N/A	Human RBC (0.6% hemolysis at 100 ug/ml)	12005420	17	L
FPDB00453	1125|||1147|||1169|||N-3	KWFKKIPKFLHLAKKF	activity value is IC50 = 17 uM||activity value is IC50 = 11 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 1.56 uM||Anti-Proteus vulgaris, activity value is MIC = 3.125 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 1.56 uM	Synthetic construct	N/A	Human RBC (1.8% hemolysis at 100 ug/ml)	12005420	16	L
FPDB00454	1126|||1148|||1170|||N-4	WFKKIPKFLHLAKKF	activity value is IC50 = 32 uM||activity value is IC50 = 23 uM||activity value is IC50 = 24 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 1.56 uM||Anti-Proteus vulgaris, activity value is MIC = 1.56 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 1.56 uM	Synthetic construct	N/A	Human RBC (1.5% hemolysis at 100 ug/ml)	12005420	15	L
FPDB00455	1127|||1149|||1171|||CAMPSQ9554	WKKIPKFLHLAKKF	activity value is IC50 = 100||activity value is IC50 = 100.0||Anti-Escherichia coli KCTC 1682, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 3.125 uM||Anti-Proteus vulgaris, activity value is MIC = 3.125 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 1.56 uM	Synthetic construct	N/A	No hemolysis, Human RBC	12005420	14	L
FPDB00456	1128|||1151|||1173|||N-4000 ml	WFKKIPKFLHLLKKF	activity value is IC50 = 5 uM||activity value is IC50 = 6 uM||activity value is IC50 = 3 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 3.125 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 1.56 uM||Anti-Proteus vulgaris, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 0.78 uM	Synthetic construct	N/A	Human RBC (28.8% hemolysis at 100 ug/ml)	12005420	15	L
FPDB00457	1129|||1130|||1152|||1174|||CAMPSQ9557	WKKIPKFLHLLKKF	activity value is IC50 = 5 uM||activity value is IC50 = 17 uM||activity value is IC50 = 14 uM||activity value is IC50 = 10 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 3.125 uM||Anti-Proteus vulgaris, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 1.56 uM	Synthetic construct	N/A	Human RBC (9.4% hemolysis at 100 ug/ml)	12005420	14	L
FPDB00458	1131|||1153|||1175|||C-1	KWKLFKKIPFLHLAKKF	activity value is IC50 = 26 uM||activity value is IC50 = 32 uM||activity value is IC50 = 31 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 6.25 uM||Anti-Proteus vulgaris, activity value is MIC = 1.56 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 1.56 uM	Synthetic construct	N/A	Human RBC (30.3% hemolysis at 100 ug/ml)	12005420	17	L
FPDB00459	1132|||1154|||1176|||C-2	KWKLFKKIPKFLHLAKK	activity value is IC50 = 28 uM||activity value is IC50 = 26 uM||activity value is IC50 = 23 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 6.25 uM||Anti-Proteus vulgaris, activity value is MIC = 1.56 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 1.56 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 1.56 uM	Synthetic construct	N/A	Human RBC (19.8% hemolysis at 100 ug/ml)	12005420	17	L
FPDB00460	1133|||1155|||1177|||C-3	KWKLFKKIPLHLAKKF	activity value is IC50 = 79 uM||activity value is IC50 = 74 uM||activity value is IC50 = 62 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 6.25 uM||Anti-Proteus vulgaris, activity value is MIC = 1.56 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 3.125 uM	Synthetic construct	N/A	Human RBC (4.7% hemolysis at 100 ug/ml)	12005420	16	L
FPDB00461	1134|||1156|||1178|||C-4	KWKLFKKIPKFLHLAK	activity value is IC50 = 54 uM||activity value is IC50 = 31 uM||activity value is IC50 = 25 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 3.125||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 6.25 uM||Anti-Proteus vulgaris, activity value is MIC = 1.56 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 1.56 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 3.125 uM	Synthetic construct	N/A	No hemolysis, Human RBC	12005420	16	L
FPDB00462	1135|||1157|||1179|||C-5	KWKLFKKIPHLAKKF	activity value is IC50 = 100 uM||activity value is IC50 = 81 uM||activity value is IC50 = 67 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 12.5 uM||Anti-Proteus vulgaris, activity value is MIC = 1.56 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 6.25 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 3.125 uM	Synthetic construct	N/A	No hemolysis, Human RBC	12005420	15	L
FPDB00463	1136|||1158|||1180|||C-6	KWKLFKKIPKFLHLA	activity value is IC50 = 47 uM||activity value is IC50 = 21 uM||activity value is IC50 = 27 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 6.25 uM||Anti-Proteus vulgaris, activity value is MIC = 3.125 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 6.25 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 3.125 uM	Synthetic construct	N/A	Human RBC (6.7% hemolysis at 100 ug/ml)	12005420	15	L
FPDB00464	1137|||1159|||1181|||CAMPSQ9564	KWKLFKKIPLAKKF	activity value is IC50 = 100||activity value is IC50 = 100.0||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 12.5 uM||Anti-Proteus vulgaris, activity value is MIC = 3.125 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 1.56 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 6.25 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 3.125 uM	Synthetic construct	N/A	No hemolysis, Human RBC	12005420	14	L
FPDB00465	1138|||1160|||1182|||CAMPSQ9565	KWKLFKKIPKFLHL	activity value is IC50 = 83 uM||activity value is IC50 = 54 uM||activity value is IC50 = 30 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 6.25 uM||Anti-Proteus vulgaris, activity value is MIC = 3.125 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 1.56 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 6.25 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 3.125 uM	Synthetic construct	N/A	No hemolysis, Human RBC	12005420	14	L
FPDB00466	1139|||1161|||1183|||C-9	KWKLFKKIPLKKF	activity value is IC50 = 100||activity value is IC50 = 100.0||Anti-Escherichia coli KCTC 1682, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 12.5 uM||Anti-Proteus vulgaris, activity value is MIC = 3.125 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 1.56 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 12.5 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 3.125 uM	Synthetic construct	N/A	Human RBC (6.2% hemolysis at 100 ug/ml)	12005420	13	L
FPDB00467	1140|||1162|||1184|||C-10	KWKLFKKIPKFLH	activity value is IC50 = 100||activity value is IC50 = 100.0||Anti-Escherichia coli KCTC 1682, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 6.25||Anti-Proteus vulgaris, activity value is MIC = 3.125 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 1.56 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 6.25 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 3.125 uM	Synthetic construct	N/A	Human RBC (7.6% hemolysis at 100 ug/ml)	12005420	13	L
FPDB00468	1150|||1172|||N-3000 ml	KWFKKIPKFLHLLKKF	activity value is IC50 = 4 uM||activity value is IC50 = 4.2 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 3.125 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 3.125 uM||Anti-Proteus vulgaris, activity value is MIC = 3.125 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 1.56 uM||Anti-Bacillus megaterium KCTC 1096, activity value is MIC = 0.78 uM	Synthetic construct	N/A	Human RBC (27.3% hemolysis at 100 ug/ml)	12005420	16	L
FPDB00469	1185|||1189|||1193|||1197|||1201|||1211|||1221|||3350|||3351|||3352|||3353|||3354|||3355|||Chain A, Cecropin A|||DRAMP03913|||DRAMP03962	KWKLFKKIGIGKFLHSAKKF	activity value is IC50 = 65 uM||activity value is IC50 = 60 uM||activity value is IC50 = 30 uM||activity value is IC50 = 44 uM||activity value is IC50 = 15.8 uM||activity value is IC50 = 16.1 uM||~90% survival rate at 10 uM||<20% survival rate at 100 uM||100% survival rate at 10 uM||0% survival rate at 100 uM||~80% survival rate at 10 uM||10% survival rate at 100 uM||Antibacterial ; Synthetic construct||Antibacterial||Antimicrobial||Antifungal	Synthetic construct|||Synthetic construct (De novo design)|||Synthetic construct	N/A	N/A	https://pubmed.ncbi.nlm.nih.gov/11009597|||Int J Mol Sci. 2012; 13(11): 15042-15053.|||Biochemistry. 2000 Oct 3;39(39):11855-11864.	20	L
FPDB00470	1188|||1192|||1196|||1200|||Cecropin A|||DRAMP31568	KWKLFKKIGPGKFLHSAKKF	IC50=>100 uM||activity value is IC50 = 75 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 3.125 uM||Anti-Salmonella typhimurium KCTC 1926, activity value is MIC = 0.78 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 0.78 uM||Anti-Bacillus subtilis KCTC 1918, activity value is MIC = 0.78 uM||Anti-Streptococcus pyogenes KCTC 3096, activity value is MIC = 0.78 uM||Anti-Staphylococcus aureus KCTC 1621, activity value is MIC = 3.125 uM||Antimicrobial||Anticancer	Synthetic construct|||Ceropin-Magainin hybrid peptides	N/A	Human erythrocytes (0% Hemolysis at 100 uM|||Human erythrocytes: Hemolysis 0% (100 uM)	10675500|||Biochim Biophys Acta. 2000 Feb 15;1463(2):209-18.	20	L
FPDB00471	1202|||1212|||1222|||AP04780|||CA	KWKLFKKIGIGAVLKVLTTG	activity value is IC50 = 32.2 uM||activity value is IC50 = 28.6 uM||Anti-and S. pyogenes . Antimalarial activity:P. falciparum, activity value is IC50 = 4 uM||Antibacterial ; Synthetic construct||Anti-E. coli D21, activity value is MIC = 0.4 uM||Anti-P. aeruginosa OT97, activity value is MIC = 0.9 uM||Anti-B. subtilis Bs11, activity value is MIC = 0.3 uM||Anti-B. megaterium Bm11, activity value is MIC = 0.2 uM||Anti-S. aureus Cowan 1, activity value is MIC = 2 uM||Anti-S. pyogenes, activity value is MIC = 0.1 uM	hybrid peptide, designed|||Synthetic construct	Helix	sheep RBC (LC >600 uM), not hemo.lytic.|||E. coli D21 ( MIC = 0.4 uM ), P. aeruginosa OT97 ( MIC = 0.9 uM) , B. subtilis Bs11 ( MIC = 0.3 uM), B. megaterium Bm11 ( MIC = 0.2 uM ), S. aureus Cowan 1 ( MIC = 2 uM ) , S. pyogenes ( MIC = 0.1 uM)||sheep red cells ( LC > 600 uM )|||sheep red cells ( LC > 600 uM )	FEBS Lett. 1992 Jan 20;296(2):190-4. doi: 10.1016/0014-5793(92)80377-s. PubMed|||https://pubmed.ncbi.nlm.nih.gov/1733777	20	L
FPDB00472	1203|||1213|||1223|||DRAMP32360	KWKLFKKIGIGAVLKVLKKG	activity value is IC50 = 3.4 uM||activity value is IC50 = 3.5 uM||activity value is IC50 = 4.5 uM||Antimicrobial||Anticancer	Ceropin A-Magainin 2	N/A	N/A	J Pept Res. 1997 Oct;50(4):279-85.	20	L
FPDB00473	1204|||1214|||1224|||DRAMP32361	KWKLFKKIGIGKFLHSATTF	activity value is IC50 = 36.2 uM||activity value is IC50 = 37.9 uM||activity value is IC50 = 47.7 uM||Antimicrobial||Anticancer	Ceropin A-Magainin 2	N/A	N/A	J Pept Res. 1997 Oct;50(4):279-85.	20	L
FPDB00474	1205|||1215|||1225|||DRAMP32362	KWKLFKKIGIGAFLHSAKKF	activity value is IC50 = 9.3 uM||activity value is IC50 = 10.9 uM||Antimicrobial||Anticancer	Ceropin A-Magainin 2	N/A	N/A	J Pept Res. 1997 Oct;50(4):279-85.	20	L
FPDB00475	1206|||1216|||1226|||DRAMP32363	KWKLFKKIGIGKFLHLAKKF	activity value is IC50 = 1.9 uM||activity value is IC50 = 1.3 uM||activity value is IC50 = 2.8 uM||Antimicrobial||Anticancer	Ceropin A-Magainin 2	N/A	N/A	J Pept Res. 1997 Oct;50(4):279-85.	20	L
FPDB00476	1207|||1217|||1227|||DRAMP32364	KWKLFKKIGIGAFLHLAKKF	activity value is IC50 = 2.9 uM||activity value is IC50 = 3.2 uM||Antimicrobial||Anticancer	Ceropin A-Magainin 2	N/A	N/A	J Pept Res. 1997 Oct;50(4):279-85.	20	L
FPDB00477	1208|||1218|||1228|||DRAMP32365	KWKLFKKIGIGKFKLAKKF	activity value is IC50 = 1.7 uM||activity value is IC50 = 2 uM||activity value is IC50 = 3.1 uM||Antimicrobial||Anticancer	Ceropin A-Magainin 2	N/A	N/A	J Pept Res. 1997 Oct;50(4):279-85.	19	L
FPDB00478	1209|||1219|||1229|||DRAMP32366	KWKLFAKIGIGKFLHLAKKF	activity value is IC50 = 3.1 uM||activity value is IC50 = 2.4 uM||Antimicrobial||Anticancer	Ceropin A-Magainin 2	N/A	N/A	J Pept Res. 1997 Oct;50(4):279-85.	20	L
FPDB00479	1210|||1220|||1230|||DRAMP32367	KWKKFLKIGIGKFLHLAKKF	activity value is IC50 = 2.6 uM||activity value is IC50 = 2.3 uM||activity value is IC50 = 1.8 uM||Antimicrobial||Anticancer	Ceropin A-Magainin 2	N/A	N/A	J Pept Res. 1997 Oct;50(4):279-85.	20	L
FPDB00480	1231|||1232|||1233|||1234|||1243|||1244|||1245|||1246|||1247|||1248|||1249|||1250|||1251|||Cecropin-B|||DRAMP03511	KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL	activity value is IC50 = 15.5 uM||activity value is IC50 = 24.8 uM||activity value is IC50 = 25.5 uM||IC50=>100 uM||activity value is IC50 = 4.4 uM||activity value is IC50 = 30.6 uM||activity value is IC50 = 33.5 uM||activity value is IC50 = 32 uM||activity value is IC50 = 37 uM||activity value is IC50 = 42.5 uM||activity value is IC50 = 34.5||activity value is IC50 = 24.5||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	Hyalophora cecropia [Cecropia moth]|||Hyalophora cecropia (Cecropia moth)	N/A	N/A	7140755, 28556271, 30823998|||Sci Rep. 2016 Jun 2;6:27258.	35	L
FPDB00481	1235|||1236|||1237|||1238|||AP00134|||AP00134|||Cecropin P1|||DRAMP03176|||Cecropin P1|||DRAMP21258	SWLSKTAKKLENSAKKRISEGIAIAIQGGPR	activity value is IC50 = 93 uM||IC50=>100 uM||Anti-Gram- L. anguillarum, activity value is MIC = 1.2 uM||Anti-E. coli, activity value is MIC = 1.2 uM||Anti-C. glutamicum, activity value is MIC = 1.6 uM||Anti-and S. aureus, activity value is MIC = 12.5 uM||Anti-L. monocytogenes EGD, activity value is MIC = 3||Anti-and P. aeruginosa MR3007, activity value is MIC = 0.3||Anti-E. coli ATCC 25922, activity value is MIC = 0.8||Anti-E. coli HB101, activity value is MIC = 0.8||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 0.8||Anti-C. glutamicum ATCC 13032, activity value is MIC = 0.4||Anti-S. cerevisiae spp, activity value is IC50 = 6.3 uM||Anti-C. albicans ATCC 10231, activity value is IC50 = 12.5 uM||Anti-B. cinerea 101, activity value is IC50 = 50 uM||Antibacterial||Anti-P1-NH2 : [E. coli K-12/ D21, activity value is MIC = 0.3 uM||Anti-E. coli 853/67/0149/K88, activity value is MIC = 0.9 uM||Anti-E. coli Bd2221/75/08/K88, activity value is MIC = 0.6 uM||Anti-E. coli Bd4462/84/0101/K99, activity value is MIC = 0.7 uM||Anti-E. coli Bd4466/84/064/K99, activity value is MIC = 0.3 uM||Anti-Salmonella typhimurium LT2, activity value is MIC = 0.9 uM||Anti-A. calcoaceticus Ac1l, activity value is MIC = 0.2 uM||Anti-Proteus vulgaris Pvll, activity value is MIC = 5.7 uM||Anti-Pseudomonas aeruginosa OT97, activity value is MIC = 5.9 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 1.8 uM||Anti-Streptococcus pyogenes, activity value is MIC = 19 uM||Anti-E. coli 853/67/0149/K88, activity value is MIC = 0.6 uM||Anti-E. coli Bd2221/75/08/K88, activity value is MIC = 0.7 uM||Anti-E. coli Bd4462/84/0101/K99, activity value is MIC = 0.8 uM||Anti-E. coli Bd4466/84/064/K99, activity value is MIC = 0.6 uM||Anti-Salmonella typhimurium LT2, activity value is MIC = 1.7 uM||Anti-A. calcoaceticus Ac1l, activity value is MIC = 0.5 uM||Anti-Proteus vulgaris Pvll, activity value is MIC = 12 uM||Anti-Pseudomonas aeruginosa OT97, activity value is MIC = 13 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 5.3 uM||Anti-Streptococcus pyogenes, activity value is MIC = 44 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC > 128 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC > 128 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC > 128 uM||Anti-Bacillus subtilis CMCC 63501, activity value is MIC = 1 uM||Anti-##Gram-negative bacteria : Escherichia coli ATCC25922, activity value is MIC = 0.5 uM||Anti-Escherichia coli UB1005, activity value is MIC = 0.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 128 uM||Anti-Salmonella typhimurium ATCC 7731, activity value is MIC = 2 uM||Anti-Salmonella pullorum C79-13, activity value is MIC = 0.5 uM	the large roundworm, Ascaris suum (living in pig)|||the large roundworm, Ascaris suum (living in pig)|||Synthetic construct|||Ascaris suum [Pig roundworm]|||Ascaris suum (Pig roundworm) (Ascaris lumbricoides)|||Synthetic construct|||Synthetic construct	Helix||Alpha helix	[Ref.29266746] MHC5>128 uM against human red blood cells	"1989 Dec;86(23):9159-62. doi: 10.1073/pnas.86.23.9159.||Lee IH et al., 1997|||Comparative Study Proc Natl Acad Sci U S A
. 1989 Dec;86(23):9159-62. doi: 10.1073/pnas.86.23.9159.||Lee IH et al., 1997|||23326415, https://doi.org/10.1046/j.1365-2761.1999.00191.x|||2512577, 11772394, 28544962|||Eur J Biochem. 1992 Oct 1;209(1):163-169.|||23326415, https://doi.org/10.1046/j.1365-2761.1999.00191.x|||Chem Biol Drug Des. 2018 May;91(5):1017-1029. doi: 10.1111/cbdd.13165.||Ref.29266746"	31	L
FPDB00482	1239|||1240|||1241|||1242	MPRWRLFRRIDRVGKQIKQGILRAGPAIALVGDARAVG	activity value is IC50 = 28.7 uM||activity value is IC50 = 56 uM||activity value is IC50 = 49.3 uM||IC50=>100 uM	N/A	N/A	N/A	N/A	38	L
FPDB00483	1350|||DRAMP31679	ETFSDLWKLL	Cytotoxicity=80% uMo/ml||Antimicrobial||Anticancer	Antennapedia	N/A	N/A	Ann Surg Oncol. 2008 Dec;15(12):3588-600.	10	L
FPDB00484	1352|||DRAMP31673	FKCRRWQWRMKKLGAPSITCVR	activity value is IC50 = 77 uM||Antimicrobial||Anticancer	Bovine lactoferrin (Lf-B)	N/A	N/A	J Pept Sci. 2008 Sep;14(9):1032-8.	22	L
FPDB00485	1353|||DRAMP31674	RKAFRWAWRMLKKAAPSITCVR	activity value is IC50 = 8 uM||Antimicrobial||Anticancer	Bovine lactoferrin (Lf-B)	N/A	N/A	J Pept Sci. 2008 Sep;14(9):1032-8.	22	L
FPDB00486	1354|||1360|||1366|||1372|||1378|||1384|||1390|||1396|||1402|||1408|||1909|||2061|||2213|||2365|||2518|||2661|||2804|||AP04135|||D Magainin-2|||AP04135	GIGKFLHAAKKFAKAFVAEIMNS	activity value is IC50 = 17 ug/ml||activity value is IC50 = 12 ug/ml||activity value is IC50 = 27 ug/ml||activity value is IC50 = 28 ug/ml||activity value is IC50 = 30 ug/ml||activity value is IC50 = 23 ug/ml||activity value is IC50 = 32 ug/ml||activity value is IC50 = 37 ug/ml||activity value is IC50 = 41 ug/ml||activity value is LD50 = 22 ug/ml||activity value is LD50 = 60 ug/ml||activity value is LD50 = 130 ug||activity value is LD50 = 130 ug/ml||activity value is LD50 = 45 ug/ml||activity value is LD50 = 125 ug/ml||Anti-Gram-||Antifungal||Antibacterial||Anti-fungi C. parasitica, activity value is MIC = 10 uM||Anti-F. oxysporum, activity value is MIC = 15 uM||Anti-and S. musiva, activity value is MIC = 5 uM||Anti-plant pathogenic bacteria A. tumefaciens, activity value is MIC = 100 uM||Anti-E.amylovora, activity value is MIC = 250 uM||Anti-and P.syringae, activity value is MIC = 250 uM	amino acid substitution, AMPHIBIAN, animal-derived, natural derivative|||Synthetic construct|||amino acid substitution, AMPHIBIAN, animal-derived, natural derivative	N/A	Rabbit erythrocytes (35% Hemolysis at 200 uM, Human erythrocytes (0% Hemolysis at 50 ug/ml, Sheep erythrocytes (50% Hemolysis at 9.6+-0.9 uM, Human erythrocytes (50% Hemolysis at 175 ug/ml, Human erythrocytes (68% Hemolysis at 100 uM	Mol Plant Microbe Interact. 1995 Sep-Oct;8(5):792-4. doi: 10.1094/mpmi-8-0792. PubMed|||3410055, 26986223, 14642822, 24102563, 26369301|||Mol Plant Microbe Interact. 1995 Sep-Oct;8(5):792-4. doi: 10.1094/mpmi-8-0792. PubMed	23	L
FPDB00487	1357|||1358|||1363|||1364|||1369|||1370|||1375|||1376|||1381|||1382|||1387|||1388|||1393|||1394|||1399|||1400|||1405|||1406|||1411|||1412|||DRAMP31662	ALSKALSKALSKALSKALSKALSK	activity value is IC50 = 97 ug/ml||activity value is IC50 = 123 ug/ml||activity value is IC50 = 60 ug/ml||activity value is IC50 = 83 ug/ml||activity value is IC50 = 107 ug/ml||activity value is IC50 = 109 ug/ml||activity value is IC50 = 115 ug/ml||activity value is IC50 = 143 ug/ml||activity value is IC50 = 80 ug/ml||activity value is IC50 = 102 ug/ml||activity value is IC50 = 64 ug/ml||activity value is IC50 = 72 ug/ml||activity value is IC50 = 98 ug/ml||activity value is IC50 = 112 ug/ml||Antimicrobial||Anticancer	Xenopus laevis	N/A	N/A	Proc Natl Acad Sci U S A. 1991 May 1;88(9):3792-6.	24	L
FPDB00488	1423|||CAMPSQ10137|||P-113unam|||P-113D|||P-113|||DRAMP04533	AKRHHGYKRKFH	15% Cytotoxicity at 0.5 ug/ml||Antibacterial||Antifungal||Antimicrobial||No MICs found in DRAMP database	Homo sapiens [Human]|||Homo sapiens|||Homo sapiens [Human]|||Homo sapiens	N/A	Gram-ve|||No hemolysis information or data found in the reference(s) presented in this entry	11302797, 28851350|||11302797|||11302797, 28851350|||Antimicrob Agents Chemother. 2001 Dec;45(12):3437-3444.	12	L
FPDB00489	1424|||AP04794|||Omiganan	ILRWPWWPWRRK	27% Cytotoxicity at 0.5 ug/ml||Anti-Gram+ E. faecalis PCM 2673, activity value is MIC = 16 ug/ml||Anti-S. aureus ATCC 25923 or 9144, activity value is MIC = 16 ug/ml||Anti-S. pneumoniae ATCC 49619, activity value is MIC = 8 ug/ml||Anti-E. coli ATCC 25922 or 23506, activity value is MIC = 16||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 16 ug/ml||Anti-A. niger ATCC 16404, activity value is MIC = 64 ug/ml||Anti-C.albicans ATCC 10231, activity value is MIC = 128 ug/ml||Anti-and C.glabrata ATCC 15126, activity value is MIC = 128 ug/ml||Antifungal	amino acid deletion, amino acid substitution, bovine cathelicidin analog, animal-derived, natural derivative|||Bos taurus [Bovine]	Rich	4% human RBC: < 10% hemolysis at 512 ug/ml.	Amino Acids. 2017 Oct;49(10):1755-1771. doi: 10.1007/s00726-017-2473-7. PubMed|||28105725	12	L
FPDB00490	1428|||1429|||1430|||1431|||3317|||3318|||3319|||3320|||3789|||3798|||3804|||3810|||NK-2|||DRAMP21012	KILRGVCKKIMRTFLRRISKDILTGKK	activity value is LD50 = 1||activity value is LD50 = 30 uM||IC50 = ~70 uM||IC50 = ~50 uM||IC50 = ~40 uM||activity value is IC50 = 4.3||activity value is IC50 = 50 uM||activity value is IC50 = 40 uM||Anti-Escherichia coli, activity value is MIC = 4 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 uM||Anti-Staphylococcus aureus, activity value is MIC = 2 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 2 uM||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 4 uM	Synthetic construct|||Mammal	Alpha helix	"- Test subject: Mouse red blood cells, incubation conditions were 37°C for 1 hour, detection wavelength 490 nm; negative control (PBS only) showed 0% hemolysis, positive control (0.2% Triton-X 100) showed 100% hemolysis.  

- Parent peptide NK-2: At a concentration of 75 μM, the hemolysis rate was 35%; at 150 μM, hemolytic activity further increased.  

- Proline-substituted analogs:  

- NK-pro (single proline substitution): At 75 μM, hemolysis rate was below 10%; at 150 μM, low hemolytic activity was still maintained.  

- NK-dpro (double proline substitution): At 75 μM, hemolysis rate was below 10%, similar to NK-pro, and significantly lower than the parent peptide.  

- Key correlation: Proline substitution did not change the net charge of the peptide (NK-2 and NK-pro are 10, NK-dpro is 9), but disrupted α-helical structure (α-helical content in membrane-mimicking environment: NK-2 was 84.4%, NK-pro was 66.0%, NK-dpro was 72.8%), thereby reducing hemolytic activity, while antimicrobial and antitumor activities also decreased to varying degrees.|||[Ref.29043494] 2.5% hemolysis at 10 ug/ml , 8% hemolysis at 25 ug/ml , 22% hemolysis at 50 ug/ml , 32.5% hemolysis at 75 ug/ml , 36% hemolysis at 150 ug/ml , 38% hemolysis at 300 ug/ml against human red blood cells"	29043494|||Probiotics Antimicrob Proteins. 2018 Mar;10(1):118-127. doi: 10.1007/s12602-017-9335-1.||Ref.29043494	27	L
FPDB00491	1432|||DRAMP31734	GIIKKIIIKKI	activity value is IC50 = 160 uM||Antimicrobial||Anticancer	AMP	N/A	Human red blood cells: over the active concentration ranges against bacteria and cancer cells, there is little activity or toxicity against hRBCs	Biomacromolecules. 2011 Nov 14;12(11):3839-43.	11	L
FPDB00492	1433|||DRAMP31735	GIIKKIIIKKIIIKKI	Antimicrobial||Anticancer	AMP	N/A	Human red blood cells: over the active concentration ranges against bacteria and cancer cells, there is little activity or toxicity against hRBCs	Biomacromolecules. 2011 Nov 14;12(11):3839-43.	16	L
FPDB00493	1438|||DRAMP31736	GIIKKIIIKKIIIKKIIIKKI	Antimicrobial||Anticancer	AMP	N/A	Human red blood cells: over the active concentration ranges against bacteria and cancer cells, there is little activity or toxicity against hRBCs	Biomacromolecules. 2011 Nov 14;12(11):3839-43.	21	L
FPDB00494	1445|||1455|||1465|||1475|||1485|||1495|||1505|||1515|||Peptide P|||DRAMP31704	KWKSFAKTFKSAKKTVAHTALKAISS	IC50=>83.6 uMo/L||Anti-Human lung carcinoma A549, activity value is IC50 > 83.6 uM||Anti-Human melanoma A375, activity value is IC50 > 83.6 uM||Anti-Human breast adenocarcinoma MCF-7, activity value is IC50 > 83.6 uM||Anti-Human colon adenocarcinoma SW1116, activity value is IC50 > 83.6 uM||Anti-Human rhabdomyosarcoma, activity value is IC50 > 83.6 uM||Anti-Human lung carcinoma H1299, activity value is IC50 > 83.6 uM||Anti-Mouse skin melanoma B16, activity value is IC50 > 83.6 uM||Anti-Human cervical carcinoma HeLa, activity value is IC50 > 83.6 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 125 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 125 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 125 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 125 uM||Anti-Human gastric cancer SGC-7901, activity value is IC50 > 125 uM||Antimicrobial||Anticancer	Synthetic construct|||PeptideV13K	N/A	Human erythrocytes (<5% Hemolysis at >500 uM, Mouse fibroblasts 3T3-L1 (50% Cell death at >125 uM|||Human red blood cells: MHC>334.3 uM	21252288, 27363513|||Mol Cancer Ther. 2011 Mar;10(3):416-26.	26	L
FPDB00495	1446|||1448|||1456|||1458|||1466|||1468|||1476|||1478|||1486|||1488|||1496|||1498|||1506|||1508|||1516|||1518|||DRAMP31705	KWKSFLKTFKSAKKTVAHTAAKAISS	IC50=>83.6 uMo/L||activity value is IC50 = 71 uM||activity value is IC50 = 59.8 uM||activity value is IC50 = 70.8 uM||activity value is IC50 = 37.7 uM||activity value is IC50 = 15.6 uM||activity value is IC50 = 64.7 uM||Antimicrobial||Anticancer	PeptideV14K	N/A	Human red blood cells: MHC>334.4 uM	Mol Cancer Ther. 2011 Mar;10(3):416-26.	26	L
FPDB00496	1447|||1457|||1467|||1477|||1487|||1497|||1507|||1517|||DRAMP31706	KWKSFLKTFKSAKKTVAHTALKAISS	IC50=>83.6 uMo/L||activity value is IC50 = 16.4 uM||Antimicrobial||Anticancer	PeptideV15K	N/A	Human red blood cells: MHC>334.4 uM	Mol Cancer Ther. 2011 Mar;10(3):416-26.	26	L
FPDB00497	1449|||1459|||1469|||1479|||1489|||1499|||1509|||1519|||L6A|||DRAMP31709	KWKSFAKTFKSAKKTVLHTALKAISS	activity value is IC50 = 53 uM||activity value is IC50 = 58.7 uM||activity value is IC50 = 62.3 uM||IC50=>83.6 uMo/L||activity value is IC50 = 14 uM||activity value is IC50 = 62.5 uM||activity value is IC50 = 58.6 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 125 ug/ml||Anti-Pseudomonas aeruginosa WR5, activity value is MIC = 250 ug/ml||Anti-Pseudomonas aeruginosa PAK, activity value is MIC = 250 ug/ml||Anti-Pseudomonas aeruginosa PA14, activity value is MIC = 500 ug/ml||Anti-Pseudomonas aeruginosa M2, activity value is MIC = 250 ug/ml||Anti-Pseudomonas aeruginosa CP204, activity value is MIC = 125 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||PeptideV18K	N/A	Human RBC (Maximum peptide concentration showing no hemolysis = 1000 ug/ml)|||Human red blood cells: MHC>334.4 uM	17158938|||Mol Cancer Ther. 2011 Mar;10(3):416-26.	26	L
FPDB00498	1450|||1460|||1470|||1480|||1490|||1500|||1510|||1520|||AP03685|||V13K|||V13KL|||DRAMP18533|||DRAMP18547	KWKSFLKTFKSAKKTVLHTALKAISS	activity value is IC50 = 33 uM||activity value is IC50 = 17.8 uM||activity value is IC50 = 15.8 uM||activity value is IC50 = 11.1 uM||activity value is IC50 = 25.2 uM||activity value is IC50 = 4.7 uM||activity value is IC50 = 11.5 uM||activity value is IC50 = 10.4 uM||Anti-Gram- E. coli ATCC 25922 or clinical strain, activity value is MIC = 2||Anti-P. aeruginosa ATCC 27853 or clinical, activity value is MIC = 8||Anti-K. pneumoniae ATCC 700603 or clinical, activity value is MIC = 4||Anti-S. aeurus ATCC 25923 or MRSA, activity value is MIC = 64||Anti-S. epidermidis ATCC 12228, activity value is MIC = 4 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC = 8 ug/ml||Anti-S. pneumoniae clinical isolate, activity value is MIC = 8 ug/ml||Anti-alpha or beta Hemolytic streptococcus, activity value is MIC = 64 ug/ml||MIC against E. coli ATCC25922||P. aeruginosa ATCC27853||S. aureus ATCC25923||B. subtilis ATCC49619||Anti-Staphylococcus aureus 25923, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus SAP0017, activity value is MIC = 64 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC = 5 ug/ml||Anti-Bacillus subtilis C971, activity value is MIC = 1.6 ug/ml||Anti-Enterococcus faecalis C625, activity value is MIC = 64 ug/ml||Anti-Corynebacterium xerosis C875, activity value is MIC = 1.3 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 2.5 ug/ml||Anti-Escherichia coli DC2, activity value is MIC = 1.6 ug/ml||Anti-Salmonella typhimurium C587, activity value is MIC = 4 ug/ml||Anti-Salmonella typhimurium C610, activity value is MIC = 1.3 ug/ml||Anti-Pseudomonas aeruginosa H187, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa H188, activity value is MIC = 5 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC = 25.4 ug/ml||Anti-Bacillus subtilis C971, activity value is MIC = 3.2 ug/ml||Anti-Corynebacterium xerosis C875, activity value is MIC = 2 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 3.2 ug/ml||Anti-Escherichia coli DC2, activity value is MIC = 2.5 ug/ml||Anti-Salmonella typhimurium C587, activity value is MIC = 32 ug/ml||Anti-Salmonella typhimurium C610, activity value is MIC = 1 ug/ml||Anti-Pseudomonas aeruginosa H187, activity value is MIC = 32 ug/ml||Anti-Pseudomonas aeruginosa H188, activity value is MIC = 25.4 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 31.3 ug/ml||Anti-Pseudomonas aeruginosa WR5, activity value is MIC = 250 ug/ml||Anti-Pseudomonas aeruginosa PAK, activity value is MIC = 125 ug/ml||Anti-Pseudomonas aeruginosa PA14, activity value is MIC = 62.5 ug/ml||Anti-Pseudomonas aeruginosa M2, activity value is MIC = 31.3 ug/ml||Anti-Pseudomonas aeruginosa CP204, activity value is MIC = 7.8 ug/ml||Anti-The geometric mean of MIC values above six Gram-positive strains, activity value is MIC = 11.8 ug/ml||Anti-##Gram-negative bacteria: Escherichia coli UB1005, activity value is MIC = 2.5 ug/ml||Anti-The geometric mean of MIC values above six Gram-negative strains, activity value is MIC = 3.1 ug/ml||Anti-The geometric mean of MIC values above six Pseudomonas aeruginosa strains, activity value is MIC = 49.6 ug/ml||Anti-The geometric mean of MIC values above six Gram-positive strains, activity value is MIC = 18.7 ug/ml||Anti-##Gram-negative bacteria: Escherichia coli UB1005, activity value is MIC = 3.2 ug/ml||Anti-The geometric mean of MIC values above six Gram-negative strains, activity value is MIC = 7.7 ug/ml	Hybrid peptide, designed, man-made sequences|||Synthetic construct|||Synthetic construct	Helix||Alpha helix	HC50 500 ug/ml, not hemo.lytic. Provided by Arjun Nair.|||Human red blood cells (MHC >250 ug/ml)|||Human RBC (Maximum peptide concentration showing no hemolysis = 250 ug/ml)|||[Ref.17158938]MHC=250 ug/ml against human red blood cells|||[Ref.15677462]MHC>250 ug/ml against human red blood cells	Peptides. 2011 Jul;32(7):1488-95. doi: 10.1016/j.peptides.2011.05.023. Pub-Med.|||15677462|||17158938|||J Biol Chem. 2005 Apr 1;280(13):12316-29.##Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406.||Ref.15677462||Ref.17158938|||J Biol Chem. 2005 Apr 1;280(13):12316-29.||Ref.15677462	26	L
FPDB00499	1451|||1461|||1471|||1481|||1491|||1501|||1511|||1521|||A12000 ml|||DRAMP18535	KWKSFLKTFKSLKKTVLHTALKAISS	activity value is IC50 = 11.1 uM||activity value is IC50 = 4.3 uM||activity value is IC50 = 5 uM||activity value is IC50 = 6.4 uM||activity value is IC50 = 7.5 uM||activity value is IC50 = 5.2 uM||activity value is IC50 = 3.8 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 15.6 ug/ml||Anti-Pseudomonas aeruginosa WR5, activity value is MIC = 62.5 ug/ml||Anti-Pseudomonas aeruginosa PAK, activity value is MIC = 31.3 ug/ml||Anti-Pseudomonas aeruginosa PA14, activity value is MIC = 31.3 ug/ml||Anti-Pseudomonas aeruginosa M2, activity value is MIC = 15.6||Anti-Pseudomonas aeruginosa CP204, activity value is MIC = 15.6 ug/ml||Anti-The geometric mean of MIC values above six Gram-negative strains, activity value is MIC = 24.8 ug/ml	Synthetic construct	Alpha helix	Human RBC (Maximum peptide concentration showing no hemolysis = 31.3 ug/ml)|||[Ref.17158938]MHC=31.3 ug/ml against human red blood cells	17158938|||Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406.||Ref.17158938	26	L
FPDB00500	1452|||1462|||1472|||1482|||1492|||1502|||1512|||1522|||A20000 ml|||DRAMP18536	KWKSFLKTFKSAKKTVLHTLLKAISS	activity value is IC50 = 8.7 uM||activity value is IC50 = 6.5 uM||activity value is IC50 = 5.1 uM||activity value is IC50 = 5 uM||activity value is IC50 = 9.8 uM||activity value is IC50 = 2.9 uM||activity value is IC50 = 7.8 uM||activity value is IC50 = 4.3 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 7.8 ug/ml||Anti-Pseudomonas aeruginosa WR5, activity value is MIC = 31.3 ug/ml||Anti-Pseudomonas aeruginosa PAK, activity value is MIC = 31.3 ug/ml||Anti-Pseudomonas aeruginosa PA14, activity value is MIC = 15.6 ug/ml||Anti-Pseudomonas aeruginosa M2, activity value is MIC = 15.6 ug/ml||Anti-Pseudomonas aeruginosa CP204, activity value is MIC = 7.8 ug/ml||Anti-Pseudomonas aeruginosa CP204, activity value is MIC = 7.7 ug/ml||Anti-The geometric mean of MIC values above six Gram-negative strains, activity value is MIC = 15.6 ug/ml	Synthetic construct	Alpha helix	Human RBC (Maximum peptide concentration showing no hemolysis = 31.3 ug/ml)|||[Ref.17158938]MHC=31.3 ug/ml against human red blood cells	17158938|||Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406.||Ref.17158938	26	L
FPDB00501	1453|||1463|||1473|||1483|||1493|||1503|||1513|||1523|||3755|||A12000 ml/A20000 ml|||DRAMP18525|||DRAMP18526|||DRAMP18527	KWKSFLKTFKSLKKTVLHTLLKAISS	activity value is IC50 = 9.7 uM||activity value is IC50 = 8.7 uM||activity value is IC50 = 6.2 uM||activity value is IC50 = 4.3 uM||activity value is IC50 = 6.4 uM||activity value is IC50 = 4.1 uM||activity value is IC50 = 4.4 uM||activity value is IC50 = 2 uM||activity value is IC50 = 1.71||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 62.5 ug/ml||Anti-Pseudomonas aeruginosa WR5, activity value is MIC = 125 ug/ml||Anti-Pseudomonas aeruginosa PAK, activity value is MIC = 62.5 ug/ml||Anti-Pseudomonas aeruginosa PA14, activity value is MIC = 125 ug/ml||Anti-Pseudomonas aeruginosa M2, activity value is MIC = 62.5 ug/ml||Anti-Pseudomonas aeruginosa CP204, activity value is MIC = 62.5 ug/ml||Anti-Cancer cell: HeLa cell, activity value is IC50 = 2.23||Anti-Cancer cell: HeLa cell, activity value is IC50 = 2.63||Anti-Cancer cell: HeLa cell, activity value is IC50 = 2.33	Synthetic construct	Alpha helix	Human RBC (Maximum peptide concentration showing no hemolysis = 8 ug/ml)|||[Ref.22837667]MHC=10.4±0.08 uM against human red blood cells|||[Ref.22837667]MHC=20.81±0.03 uM against human red blood cells|||[Ref.22837667]MHC=20.81±0.13 uM against human red blood cells	17158938|||Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	L
FPDB00502	1454|||1464|||1474|||1484|||1494|||1504|||1514|||1524|||A12000 ml/A20000 ml/A23000 ml	KWKSFLKTFKSLKKTVLHTLLKLISS	activity value is IC50 = 9.2 uM||activity value is IC50 = 7.2 uM||activity value is IC50 = 5.7 uM||activity value is IC50 = 3.5 uM||activity value is IC50 = 5.5 uM||activity value is IC50 = 2.7 uM||activity value is IC50 = 4.6 uM||activity value is IC50 = 2.2 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 500 ug/ml||Anti-Pseudomonas aeruginosa WR5, activity value is MIC = 500 ug/ml||Anti-Pseudomonas aeruginosa PAK, activity value is MIC = 500 ug/ml||Anti-Pseudomonas aeruginosa PA14, activity value is MIC = 500 ug/ml||Anti-Pseudomonas aeruginosa M2, activity value is MIC = 500 ug/ml||Anti-Pseudomonas aeruginosa CP204, activity value is MIC = 500 ug/ml	Synthetic construct	N/A	Human RBC (Maximum peptide concentration showing no hemolysis = 4 ug/ml)	17158938	26	L
FPDB00503	1525|||1531|||1537	LLGDFFRKSKEK	N/A	N/A	N/A	N/A	N/A	12	L
FPDB00504	1526|||1532|||1538|||AP02855|||C-terminal fragment, LL-37|||LL-37	IGKEFKRIVQRIKDFLRNLVPRTES	LC50=39 uM||LC50=40 uM||LC50=38 uM||Active against E. coli and S. aureus.||Antibacterial||Anticancer||Anti-Escherichia coli K12, activity value is MIC = 80 uM	Synthetic construct|||Homo sapiens	Helix	Sequence truncation, human cathelicidin analog, animal-derived, natural derivative	"J Am Chem Soc
. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875.|||16637646"	25	L
FPDB00505	1527|||1533|||1536|||1539|||1542|||LL17-32|||LL-37	FKRIVQRIKDFLRNLV	LC50=30 uM||LC50=25 uM||Anti-Streptococcus agalactiae NEM 316, activity value is MIC = 90||Anti-Escherichia coli K12, activity value is MIC = 20 uM	Homo sapiens	N/A	N/A	31417238|||16637646	16	L
FPDB00506	1535|||1541|||LL-37	LLGDFKRIVQRIKDF	Anti-Escherichia coli K12, activity value is MIC = 250 uM	Homo sapiens	N/A	N/A	16637646	15	L
FPDB00507	1547|||DRAMP31675	KAQIRAMECNIL	Antimicrobial||Anticancer	Cyclin B (285-296)	N/A	N/A	Bioorg Med Chem Lett. 2008 Aug 15;18(16):4633-7.	12	L
FPDB00508	1548	RKKRRQRRR	~10% Cytotoxicity at 100 uM	N/A	N/A	N/A	N/A	9	L
FPDB00509	1549|||DRAMP31676	KAQIRAMECNILGRKKRRQRRR	~80% Cytotoxicity at 100 uM||Antimicrobial||Anticancer	HIV-Tat (49-57)	N/A	N/A	Bioorg Med Chem Lett. 2008 Aug 15;18(16):4633-7.	22	L
FPDB00510	1604|||1619|||1634	PEWFKCRRWQWRMKKLGA	IC50=>404 uM	N/A	N/A	N/A	N/A	18	L
FPDB00511	1605|||1620|||1635|||DRAMP31570	PAWFKARRWAWRMKKLAA	activity value is IC50 = 144 uM||IC50=>254 uM||IC50=>440 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50>440 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00512	1606|||1621|||1636|||DRAMP31571	PAWRKAFRWAWRMKKLAA	activity value is IC50 = 32 uM||activity value is IC50 = 18 uM||activity value is IC50 = 141 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50>440 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00513	1607|||1622|||1637|||Undefined|||DRAMP31572	PAWFKARRWAWRMLKKAA	activity value is IC50 = 31 uM||activity value is IC50 = 16 uM||activity value is IC50 = 57 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Human red blood cells: EC50>440 uM	11481289|||J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00514	1608|||1623|||1638|||DRAMP31573	PAWRKAFRWAWRMLKKAA	activity value is IC50 = 6.6 uM||activity value is IC50 = 8 uM||activity value is IC50 = 14 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50=33 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00515	1609|||1624|||1639|||DRAMP31574	PAWRKAFRWAARMLKKAA	activity value is IC50 = 11 uM||activity value is IC50 = 12 uM||activity value is IC50 = 15 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50=278 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00516	1610|||1625|||1640|||DRAMP31575	PAWRKAFRAAWRMLKKAA	activity value is IC50 = 16 uM||activity value is IC50 = 11 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50=382 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00517	1611|||1626|||1641|||DRAMP31576	PAWAKAFRAAARMKLKAA	activity value is IC50 = 110 uM||activity value is IC50 = 12 uM||activity value is IC50 = 180 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50>489 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00518	1612|||1627|||1642|||DRAMP31577	PAWRKAARWAWRMLKKAA	activity value is IC50 = 35 uM||activity value is IC50 = 32 uM||activity value is IC50 = 52 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50>455 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00519	1613|||1628|||1643|||DRAMP31578	PAARKAFRWAWRMLKKAA	activity value is IC50 = 24 uM||activity value is IC50 = 20 uM||activity value is IC50 = 35 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50>463 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00520	1614|||1629|||1644|||DRAMP31582	PAARKAARWAWRMLKKGA	activity value is IC50 = 116 uM||activity value is IC50 = 75 uM||activity value is IC50 = 248 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50>480 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00521	1615|||1630|||1645|||DRAMP31583	PAWRKAFRWAKRMLKKAA	activity value is IC50 = 7.9 uM||activity value is IC50 = 10 uM||activity value is IC50 = 25 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50>451 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00522	1616|||1631|||1646|||DRAMP31584	PAWRKAFRKAWRMLKKAA	activity value is IC50 = 14 uM||activity value is IC50 = 12 uM||activity value is IC50 = 29 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50>451 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00523	1617|||1632|||1647|||DRAMP31585	PAWRKARRWAWRMKKLAA	activity value is IC50 = 125 uM||activity value is IC50 = 141 uM||activity value is IC50 = 423 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50>438 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00524	1618|||1633|||1648|||DRAMP31586	PAWRKARRWARRMKKLAA	activity value is IC50 = 87 uM||activity value is IC50 = 92 uM||activity value is IC50 = 178 uM||Antimicrobial||Anticancer	Synthetic	N/A	Human red blood cells: EC50>444 uM	J Pept Res. 2002 Oct;60(4):187-97.	18	L
FPDB00525	1651|||1655|||1659|||1663	GIGVLLSAGKAALKGLAKVLAEKYAN	activity value is IC50 = 24.2 ug/ml||activity value is IC50 = 53.4 ug/ml||IC50 =>50 ug/ml||IC50=>50 ug/ml	N/A	N/A	N/A	N/A	26	L
FPDB00526	1665|||1666|||1667|||1668|||1669|||DRAMP31157|||ApoE|||DRAMP31157	LRVRLASHLRKLRKRLLRDADDLQKRLAVY	55 % Cytotoxity at 40 ug/ml||60 % Cytotoxity at 40 ug/ml||35 % Cytotoxity at 40 ug/ml||65 % Cytotoxity at 40 ug/ml||Anti-hepatitis C virus :inhibition of infection in Huh7.5.1 cells, activity value is IC50 > 10 uM||Antiviral ; Hepatitis C virus (HCV) JFH-1[IC50 I >10 uM]||Antimicrobial||Antiviral	Synthetic construct(derived from human apolipoprotein E)|||Synthetic construct|||Synthetic construct(derived from human apolipoprotein E)	N/A	N/A	Ref.22334503|||https://pubmed.ncbi.nlm.nih.gov/22334503|||Hepatology. 2012 Aug;56(2):484-91.	30	L
FPDB00527	1671|||1675|||1679|||1683|||1687|||1691|||1695|||1699|||1703|||DRAMP31798	LLRHVVKILSKYL	62.73 Inhibition ratio at 50 ug/ml||59.37 Inhibition ratio at 50 ug/ml||56.81 Inhibition ratio at 50 ug/ml||55.98 Inhibition ratio at 50 ug/ml||50.85 Inhibition ratio at 50 ug/ml||50.64 Inhibition ratio at 50 ug/ml||37.00 Inhibition ratio at 50 ug/ml||30.90 Inhibition ratio at 50 ug/ml||27.99 Inhibition ratio at 50 ug/ml||Antimicrobial||Anticancer	Temporins family	N/A	Showed no hemolytic activity against rabbit erythrocytes and human erythrocytes at 250 ug/ml	J Pept Sci. 2012 Jul;18(7):476-86.	13	L
FPDB00528	1672|||1676|||1680|||1684|||1688|||1692|||1696|||1700|||1704|||DRAMP31799	RGDLLRHVVKILEKYL	72.69 Inhibition ratio at 50 ug/ml||70.39 Inhibition ratio at 50 ug/ml||73.09 Inhibition ratio at 50 ug/ml||60.22 Inhibition ratio at 50 ug/ml||62.49 Inhibition ratio at 50 ug/ml||47.26Inhibition ratio at 50 ug/ml||36.25 Inhibition ratio at 50 ug/ml||27.86 Inhibition ratio at 50 ug/ml||19.76 Inhibition ratio at 50 ug/ml||Antimicrobial||Anticancer	Arg-Gly-Asp(RGD) tripeptide ana temporins	N/A	Showed no hemolytic activity against rabbit erythrocytes and human erythrocytes at 250 ug/ml	J Pept Sci. 2012 Jul;18(7):476-86.	16	L
FPDB00529	1673|||1677|||1681|||1685|||1689|||1693|||1697|||1701|||1705|||DRAMP31800	RGDLLRHVVKILSKYL	81.465 Inhibition ratio at 50 ug/ml||86.175 Inhibition ratio at 50 ug/ml||78.045 Inhibition ratio at 50 ug/ml||73.07 Inhibition ratio at 50 ug/ml||73.705 Inhibition ratio at 50 ug/ml||52.50 Inhibition ratio at 50 ug/ml||38.13 Inhibition ratio at 50 ug/ml||32.52 Inhibition ratio at 50 ug/ml||29.33 Inhibition ratio at 50 ug/ml||Antimicrobial||Anticancer	Arg-Gly-Asp(RGD) tripeptide ana temporins	N/A	Showed no hemolytic activity against rabbit erythrocytes and human erythrocytes at 250 ug/ml	J Pept Sci. 2012 Jul;18(7):476-86.	16	L
FPDB00530	1707|||AP00163|||Dermaseptin-B4|||Dermaseptin-2|||DRAMP01651	ALWKDILKNVGKAAGKAVLNTVTDMVNQ	Cytotoxicity =15 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 3 uM||Anti-P. aeruginosa CIP A22, activity value is MIC = 4.6 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 11.6 uM||Anti-and E. coli 54127, activity value is MIC = 2.3 uM||Anti-E. coli ATCC 25922, activity value is MIC = 5 uM||Anti-E. coli 54127, activity value is MIC = 2.3 uM||Staphylococcus aureus||Escherichia coli||Pseudomonas aeruginosa||Candida albicans||Paracoccidioides brasiliensis||Anti-Staphylococcus aureus ATCC 25293, activity value is MIC = 1.3 uM||Anti-Pseudomonas aeruginosa CIP A22, activity value is MIC = 4.6 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 11.6 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5 uM	South American frog, Phyllomedusa bicolor|||Phyllomedusa bicolor [Two-colored leaf frog]|||Phyllomedusa tarsius [Brownbelly leaf frog]|||Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)	Alpha helix	N/A	"J Biol Chem
. 1998 Jun 12;273(24):14690-7. doi: 10.1074/jbc.273.24.14690.||Marenah L et al., 2004 Pancreas. Aug;29(2):110-5||Proaño-Bolaños C et al., 2016|||9614066"	28	L
FPDB00531	1710|||1711|||1712|||1713|||1714|||1715|||1734|||1738|||1742|||1743|||1744|||1745|||1746|||1747|||1748|||3240|||3241|||3242|||3243|||3244|||3245|||3246|||3741|||3742|||3743|||3745|||3746|||GA-K3	FLGWLFKWAKK	activity value is IC50 = 27390 uM||activity value is IC50 = 25200 uM||activity value is IC50 = 24760 uM||activity value is IC50 = 26700 uM||activity value is IC50 = 47690 uM||activity value is IC50 = 41210 uM||activity value is IC50 = 27000 uM||activity value is IC50 = 41.21 uM||activity value is IC50 = 25.2 uM||activity value is IC50 = 27 uM||activity value is IC50 = 26.7 uM||activity value is IC50 = 47.69 uM||activity value is IC50 = 27.39 uM||IC50||Anti-B. subtilis, activity value is MIC = 6.3 ug/ml||Anti-M. luteus, activity value is MIC = 3.1 ug/ml||Anti-S. aureus, activity value is MIC = 12.5 ug/ml||Anti-S. epidermis, activity value is MIC = 6.3 ug/ml||Anti-E. coli, activity value is MIC = 12.5 ug/ml||Anti-S. dysentariae, activity value is MIC = 25 ug/ml||Anti-S. typhimorium, activity value is MIC = 50 ug/ml||Anti-K. pneumoniae, activity value is MIC = 12.5 ug/ml||Anti-P. aeruginosa, activity value is MIC = 25 ug/ml	Synthetic construct	N/A	Human erythrocytes(<40% hemolysis at 100 ug/ml)	21110126	11	L
FPDB00532	1716|||1717|||1718|||1719|||1720|||1721|||1735|||1739|||1749|||1750|||1751|||1752|||1753|||1754|||1755|||1756|||3247|||3248|||3249|||3250|||3251|||3252|||3253|||3747|||3748|||3749|||3750|||3751|||3752|||3753|||3754|||Gaegurin 5	FLKWLFKWAKK	activity value is IC50 = 22250 uM||activity value is IC50 = 14530 uM||activity value is IC50 = 12550 uM||activity value is IC50 = 22510 uM||activity value is IC50 = 29100 uM||activity value is IC50 = 21480 uM||activity value is IC50 = 14800 uM||activity value is IC50 = 21.48 uM||activity value is IC50 = 14.53 uM||activity value is IC50 = 14.8 uM||activity value is IC50 = 22.51 uM||activity value is IC50 = 29.1 uM||activity value is IC50 = 22.25 uM||activity value is IC50 = 12.55 uM||activity value is IC50 = 24.76 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 3.1 ug/ml||Anti-Micrococcus luteus ATCC 10240, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus ATCC 6538P, activity value is MIC = 6.3 ug/ml||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 6.3 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 12.5 ug/ml||Anti-Shigella dysenteriae ATCC 9752, activity value is MIC = 25 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028, activity value is MIC = 50 ug/ml||Anti-Klebsiella pneumoniae ATCC 10031, activity value is MIC = 12.5 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 12.5 ug/ml||Anti-Human renal carcinoma A498, activity value is IC50 = 21.48 uM||Anti-Human lung carcinoma A549, activity value is IC50 = 14.53 uM||Anti-Human colon adenocarcinoma HCT 116, activity value is IC50 = 14.8 uM||Anti-Human gastric cancer MKN 45, activity value is IC50 = 22.51 uM||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 29.1 uM||Anti-Human skin melanoma SK-MEL-2, activity value is IC50 = 22.25 uM||Anti-Human ovarian adenocarcinoma SK-OV-3, activity value is IC50 = 12.55 uM	Synthetic construct	N/A	N/A	22644847	11	L
FPDB00533	1722|||1723|||1724|||1725|||1726|||1727|||1736|||1740|||1757|||1758|||1759|||1760|||1761|||1762|||1763|||1764|||3226|||3227|||3228|||3229|||3230|||3231|||3232|||3727|||3728|||3729|||3730|||3732|||3733|||GA-W3	FLGWLFKWAWK	activity value is IC50 = 13970 uM||activity value is IC50 = 20360 uM||activity value is IC50 = 22060 uM||activity value is IC50 = 24310 uM||activity value is IC50 = 46510 uM||activity value is IC50 = 24630 uM||activity value is IC50 = 48000 uM||activity value is IC50 = 22310 uM||activity value is IC50 = 22.88 uM||activity value is IC50 = 20.36 uM||activity value is IC50 = 24.63 uM||activity value is IC50 = 24.31 uM||activity value is IC50 = 46.51 uM||activity value is IC50 = 13.97 uM||activity value is IC50 = 22.06 uM||Anti-B. subtilis, activity value is MIC = 6.3 ug/ml||Anti-M. luteus, activity value is MIC = 3.1 ug/ml||Anti-S. aureus, activity value is MIC = 6.3 ug/ml||Anti-S. epidermis, activity value is MIC = 6.3 ug/ml||Anti-E. coli, activity value is MIC = 25 ug/ml||Anti-S. dysentariae, activity value is MIC = 12.5 ug/ml||Anti-S. typhimorium, activity value is MIC = 100 ug/ml||Anti-K. pneumoniae, activity value is MIC = 12.5 ug/ml||Anti-P. aeruginosa, activity value is MIC > 200 ug/ml	Synthetic construct	N/A	Human erythrocytes(<40% hemolysis at 100 ug/ml)	21110126	11	L
FPDB00534	1728|||1729|||1730|||1731|||1732|||1733|||1737|||1741|||1765|||1766|||1767|||1768|||1769|||1770|||1771|||1772|||3233|||3234|||3235|||3236|||3237|||3238|||3239|||3734|||3735|||3736|||3737|||3738|||3739|||3740|||GA-W4	FLWWLFKWAWK	activity value is IC50 = 13160 uM||activity value is IC50 = 14800 uM||activity value is IC50 = 14580 uM||activity value is IC50 = 13770 uM||activity value is IC50 = 24320 uM||activity value is IC50 = 57000 uM||activity value is IC50 = 15880 uM||activity value is IC50 = 22.59 uM||activity value is IC50 = 15.88 uM||activity value is IC50 = 14.8 uM||activity value is IC50 = 13.77 uM||activity value is IC50 = 24.32 uM||activity value is IC50 = 13.16 uM||activity value is IC50 = 14.58 uM||Anti-B. subtilis, activity value is MIC = 3.1 ug/ml||Anti-M. luteus, activity value is MIC = 3.1 ug/ml||Anti-S. aureus, activity value is MIC = 6.3 ug/ml||Anti-S. epidermis, activity value is MIC = 3.1 ug/ml||Anti-E. coli, activity value is MIC > 200 ug/ml||Anti-S. dysentariae, activity value is MIC = 200 ug/ml||Anti-S. typhimorium, activity value is MIC > 200 ug/ml||Anti-K. pneumoniae, activity value is MIC = 200 ug/ml||Anti-P. aeruginosa, activity value is MIC > 200 ug/ml	Synthetic construct	N/A	Human erythrocytes(<60% hemolysis at 100 ug/ml)	21110126	11	L
FPDB00535	1773|||1774|||1925|||1926|||2077|||2078|||2229|||2230|||2381|||2382|||2524|||2525|||2667|||2668|||Antibacterial peptide/melittin homolog|||DRAMP03850	FALALKALKKALKKLKKALKKAL	activity value is LD50 = 54 ug/ml||activity value is LD50 = 23 ug/ml||activity value is LD50 = 6 ug/ml||activity value is LD50 = 46 ug/ml||activity value is LD50 = 72 ug/ml||activity value is LD50 = 128 ug/ml||activity value is LD50 = 44 ug/ml||activity value is LD50 = 140 ug/ml||activity value is LD50 = 61 ug/ml||activity value is LD50 = 95 ug/ml||activity value is LD50 = 50 ug/ml||Antibacterial||Antimicrobial||Anti-Gram-	Synthetic construct	N/A	N/A	8714745|||Scanning Microsc. 1995 Jun;9(2):501-507.	23	L
FPDB00536	1775|||1776|||1927|||1928|||2079|||2080|||2231|||2232|||2383|||2384|||2526|||2527|||2669|||2670|||M-Cecropin-B	MPKWKVFKKIEKVGRNIRNGIVKAGPAIAVLGEAKALG	activity value is LD50 = 175 ug/ml||activity value is LD50 = 540 ug/ml||activity value is LD50 = 82 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 120 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 220 ug/ml||activity value is LD50 = 720 ug/ml||activity value is LD50 = 630 ug/ml||activity value is LD50 = 150 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 100 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 50 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MFC > 200 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC = 50 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC > 60 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 40 ug/ml||Anti-Pseudomonas syringae pv. tabaci, activity value is LD50 = 5.2 uM||Anti-Ralstonia solanacearum, activity value is LD50 = 64 uM||Anti-Pectobacterium carotovorum subsp. carotovorum, activity value is LD50 = 1.48 uM||Anti-Xanthomonas campestris pv. campestris, activity value is LD50 = 0.57 uM||Anti-Human breast adenocarcinoma MCF-7, activity value is LD50 = 175 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 82 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 120 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 220 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 = 150 ug/ml||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC > 200 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 75 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is LD50 = 540 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 > 1000 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 > 1000 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 720 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 > 1000 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 630 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 1 ug/ml||Anti-Salmonella enterica serovar Typhimurium, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa M76, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M917, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa M1251, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa M1426, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa R70, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus, activity value is MIC > 128 ug/ml||Anti-Candida albicans, activity value is MIC > 128 ug/ml||Anti-Pseudomonas stutzeri, activity value is MIC = 4 ug/ml||Anti-Pseudomonas fluorescens, activity value is MIC = 8 ug/ml||Anti-Ralstonia pickettii, activity value is MIC = 8 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 2 ug/ml||Anti-Achromobacter xylosoxidans, activity value is MIC = 32 ug/ml	Synthetic construct	N/A	Human erythrocytes (50% Hemolysis at >1000 ug/ml	15980369	38	L
FPDB00537	1777|||1929|||2081|||2233|||2385|||2528|||2671	FAKKLAKKLKKLAKKLAKLALAL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 83 ug/ml	N/A	N/A	N/A	N/A	23	L
FPDB00538	1778|||1930|||2082|||2234|||2386|||2529|||2672	FALAAKALKKLAKKLKKLAKKAL	activity value is LD50 = 62 ug/ml||activity value is LD50 = 5 ug/ml||activity value is LD50 = 27 ug/ml||activity value is LD50 = 64 ug/ml||activity value is LD50 = 41 ug/ml||activity value is LD50 = 82 ug/ml	N/A	N/A	N/A	N/A	23	L
FPDB00539	1779|||1931|||2083|||2235|||2387|||2530|||2673|||HB25, FLAKO3 AMD	FALALKALKKLLKKLKKLAKKAL	activity value is LD50 = 26 ug/ml||activity value is LD50 = 38 ug/ml||activity value is LD50 = 85 ug/ml||activity value is LD50 = 72 ug/ml||activity value is LD50 = 145 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli UB1005, activity value is MIC = 4 ug/ml||Anti-Salmonella enterica serovar Typhimurium, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M76, activity value is MIC = 32 ug/ml||Anti-Pseudomonas aeruginosa M917, activity value is MIC = 128 ug/ml||Anti-Pseudomonas aeruginosa M1251, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa M1426, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa R70, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||Anti-Candida albicans, activity value is MIC = 64 ug/ml||Anti-Pseudomonas stutzeri, activity value is MIC = 2 ug/ml||Anti-Pseudomonas fluorescens, activity value is MIC = 8 ug/ml||Anti-Ralstonia pickettii, activity value is MIC = 4 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 4 ug/ml||Anti-Achromobacter xylosoxidans, activity value is MIC = 32 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC > 80 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 30 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC > 40 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MFC > 50 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is LD50 = 26 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 38 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 85 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 72 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 = 145 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 38 ug/ml	Synthetic construct	N/A	Human fibroblasts WI-38 (LD50 at 55 ug/ml	15980369	23	L
FPDB00540	1780|||1932|||2075|||2084|||2227|||2236|||2388|||2531|||2674|||FLAKO4 AMD	FALALKALKKLAKKLKKLAKKAL	activity value is LD50 = 10 ug/ml||activity value is LD50 = 12 ug/ml||activity value is LD50 = 36 ug/ml||activity value is LD50 = 37 ug/ml||activity value is LD50 = 20 ug/ml||Antibacterial||Antifungal||Anti-Human breast adenocarcinoma MCF-7, activity value is EC50 = 4 uM||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 5 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MFC = 25 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC = 40 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 30 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 40 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MFC > 50 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 12 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 36 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 37 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 = 20 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 12 ug/ml	Synthetic construct	N/A	Human erythrocytes (50% Hemolysis at 6.4 uM	29679519	23	L
FPDB00541	1781|||1933|||2085|||2237|||2389|||2532|||2675	FALAKLAKKAKAKLKKALKAL	activity value is LD50 = 74 ug/ml||activity value is LD50 = 8 ug/ml||activity value is LD50 = 94 ug/ml||activity value is LD50 = 84 ug/ml||activity value is LD50 = 125 ug/ml||activity value is LD50 = 150 ug/ml	N/A	N/A	N/A	N/A	21	L
FPDB00542	1782|||1783|||1934|||1935|||2086|||2087|||2238|||2239|||2390|||2391|||2533|||2534|||2676|||2677|||FLAKO6 AMD|||FLAK25 AMD|||FLAKO6 AMD	FALALKALKKLKKALKKAL	activity value is LD50 = 14 ug/ml||activity value is LD50 = 65 ug/ml||activity value is LD50 = 26 ug/ml||activity value is LD50 = 59 ug/ml||activity value is LD50 = 44 ug/ml||activity value is LD50 = 93 ug/ml||activity value is LD50 = 16 ug/ml||activity value is LD50 = 54 ug/ml||activity value is LD50 = 8 ug/ml||activity value is LD50 = 25 ug/ml||activity value is LD50 = 80 ug/ml||Antibacterial ; Synthetic construct||Anti-Human breast adenocarcinoma MCF-7, activity value is EC50 = 7 uM||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 10 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MFC = 25 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC = 10 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 8 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MFC > 50 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 26 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 44 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 16 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 = 25 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 8 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC = 40 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 10 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC > 40 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MFC > 40 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is LD50 = 65 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 59 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 93 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 54 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 = 80 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 16 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is EC50 = 4 uM||Anti-Escherichia coli ATCC 25922, activity value is MBC = 30 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 15 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 10 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 30 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 56 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 57 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 19 ug/ml	Synthetic construct	N/A	Human breast adenocarcinoma MCF-7[EC50 = 7 uM], Staphylococcus aureus ATCC 6538[MIC = 10 ug/ml], Pseudomonas aeruginosa ATCC 9027[MIC = 10 ug/ml], Saccharomyces cerevisiae[MFC = 25 ug/ml], Escherichia coli ATCC 25922[MBC = 10 ug/ml], Pseudomonas aeruginosa ATCC 27853[MBC = 8 ug/ml], Staphylococcus aureus ATCC 25923[MBC = 8 ug/ml], Candida albicans ATCC 10231[MFC >50 ug/ml], Human colon adenocarcinoma SW480[LD50 = 26 ug/ml], Human melanoma BMKC[LD50 = 44 ug/ml], Human lung carcinoma H1299[LD50 = 16 ug/ml], Human cervical carcinoma HeLa S3[LD50 = 25 ug/ml], Human prostate adenocarcinoma PC-3[LD50 = 8 ug/ml], Escherichia coli ATCC 25922[MBC = 40 ug/ml], Pseudomonas aeruginosa ATCC 27853[MBC = 10 ug/ml], Staphylococcus aureus ATCC 25923[MBC >40 ug/ml], Candida albicans ATCC 10231[MFC >40 ug/ml], Human breast adenocarcinoma MCF-7[LD50 = 65 ug/ml], Human colon adenocarcinoma SW480[LD50 = 59 ug/ml], Human melanoma BMKC[LD50 = 93 ug/ml], Human lung carcinoma H1299[LD50 = 54 ug/ml], Human cervical carcinoma HeLa S3[LD50 = 80 ug/ml], Human prostate adenocarcinoma PC-3[LD50 = 16 ug/ml]||Human erythrocytes (50% Hemolysis at 62.3 uM|||Human breast adenocarcinoma MCF-7[EC50 = 4 uM], Escherichia coli ATCC 25922[MBC = 30 ug/ml], Pseudomonas aeruginosa ATCC 27853[MBC = 15 ug/ml], Staphylococcus aureus ATCC 25923[MBC = 10 ug/ml], Candida albicans ATCC 10231[MFC >40 ug/ml], Human colon adenocarcinoma SW480[LD50 = 30 ug/ml], Human melanoma BMKC[LD50 = 56 ug/ml], Human lung carcinoma H1299[LD50 = 57 ug/ml], Human prostate adenocarcinoma PC-3[LD50 = 19 ug/ml]||Human erythrocytes (50% Hemolysis at 37.6 uM|||Human erythrocytes (50% Hemolysis at 62.3 uM|||Human erythrocytes (50% Hemolysis at 37.6 uM|||Human erythrocytes (50% Hemolysis at 62.3 uM	https://pubmed.ncbi.nlm.nih.gov/29679519|||29679519	19	L
FPDB00543	1784|||1936|||2088|||2240|||2392|||2535|||2678	FAKKLAKKLKKLAKLALAL	activity value is LD50 = 140 ug/ml||activity value is LD50 = 210 ug/ml||activity value is LD50 = 300 ug/ml||activity value is LD50 = 170 ug/ml||activity value is LD50 = 280 ug/ml||activity value is LD50 = 260 ug/ml	N/A	N/A	N/A	N/A	19	L
FPDB00544	1785|||1921|||1922|||1937|||2073|||2074|||2089|||2225|||2226|||2241|||2377|||2378|||2393|||2536|||2679	VALALKALKKALKKLKKALKKAL	activity value is LD50 = 72 ug/ml||activity value is LD50 = 340 ug/ml||activity value is LD50 = 160 ug/ml||activity value is LD50 = 62 ug/ml||activity value is LD50 = 140 ug/ml||activity value is LD50 = 140 ug||activity value is LD50 = 125 ug/ml||activity value is LD50 = 65 ug/ml||activity value is LD50 = 190 ug/ml	N/A	N/A	N/A	N/A	23	L
FPDB00545	1786|||1938|||2090|||2242|||2394|||2537|||2680	FALALKKALKALKKAL	activity value is LD50 = 21 ug/ml||activity value is LD50 = 35 ug/ml||activity value is LD50 = 53 ug/ml||activity value is LD50 = 53 ug||activity value is LD50 = 24 ug/ml||activity value is LD50 = 9 ug/ml||activity value is LD50 = 62 ug/ml	N/A	N/A	N/A	N/A	16	L
FPDB00546	1787|||1811|||1939|||1963|||2091|||2115|||2243|||2267|||2395|||2419|||2538|||2562|||2681|||2705|||HB35, FLAK26 AMD	FAKKLAKLAKKLAKLAL	activity value is LD50 = 9 ug/ml||activity value is LD50 = 105 ug/ml||activity value is LD50 = 14 ug/ml||activity value is LD50 = 100 ug/ml||activity value is LD50 = 7 ug/ml||activity value is LD50 = 140 ug/ml||activity value is LD50 = 16 ug/ml||activity value is LD50 = 127 ug/ml||activity value is LD50 = 5 ug/ml||activity value is LD50 = 66 ug/ml||activity value is LD50 = 27 ug/ml||activity value is LD50 = 170 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 2 ug/ml||Anti-Salmonella enterica serovar Typhimurium, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa M76, activity value is MIC = 2 ug/ml||Anti-Pseudomonas aeruginosa M917, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M1251, activity value is MIC = 2 ug/ml||Anti-Pseudomonas aeruginosa M1426, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa R70, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||Anti-Candida albicans, activity value is MIC = 32 ug/ml||Anti-Pseudomonas stutzeri, activity value is MIC = 4 ug/ml||Anti-Pseudomonas fluorescens, activity value is MIC = 8 ug/ml||Anti-Ralstonia pickettii, activity value is MIC = 4 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 2 ug/ml||Anti-Achromobacter xylosoxidans, activity value is MIC = 16 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is EC50 = 5 uM||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 5 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MBC = 200 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MFC = 25 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC = 8 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 10 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MFC > 40 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 14 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 7 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 15 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 = 27 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC = 4 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 50 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC > 80 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is LD50 = 105 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 100 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 140 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 127 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 = 170 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 66 ug/ml	Synthetic construct	N/A	Human erythrocytes (50% Hemolysis at 112.5 uM, Human fibroblasts WI-38 (LD50 at 8 ug/ml	29679519, 15980369	17	L
FPDB00547	1788|||1915|||1940|||2067|||2070|||2092|||2244|||2396|||2539|||2682|||FLAK25 AMD	FAKKLAKLAKKLAKLALAL	activity value is LD50 = 9 ug/ml||activity value is LD50 = 23 ug/ml||activity value is LD50 = 30 ug/ml||activity value is LD50 = 56 ug/ml||activity value is LD50 = 57 ug/ml||activity value is LD50 = 19 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is EC50 = 4 uM||Anti-Escherichia coli ATCC 25922, activity value is MBC = 30 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 15 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 10 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MFC > 40 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 30 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 56 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 57 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 19 ug/ml	N/A	N/A	Human erythrocytes (50% Hemolysis at 37.6 uM	29679519	19	L
FPDB00548	1791|||2095|||2247|||2399|||2542|||2685	FAKKLAKLAKKALAL	activity value is LD50 = 130 ug/ml||activity value is LD50 = 510 ug/ml||activity value is LD50 = 420 ug/ml||activity value is LD50 = 310 ug/ml||activity value is LD50 = 620 ug/ml	N/A	N/A	N/A	N/A	15	L
FPDB00549	1792|||1944|||2248|||2400|||2543|||2686	FALAKKALKKAKKAL	activity value is LD50 = 760 ug/ml||LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 435 ug/ml	N/A	N/A	N/A	N/A	15	L
FPDB00550	1793|||1945|||2097|||2401|||2544|||2687	FAKKLAKKLKKLAKLALAK	activity value is LD50 = 98 ug/ml||activity value is LD50 = 120 ug/ml||activity value is LD50 = 290 ug/ml||activity value is LD50 = 245 ug/ml||activity value is LD50 = 140 ug/ml||activity value is LD50 = 185 ug/ml	N/A	N/A	N/A	N/A	19	L
FPDB00551	1795|||1947|||2099|||2251|||2403|||2689	FAKLLAKLAKKLL	activity value is LD50 = 9 ug/ml||activity value is LD50 = 7 ug/ml||activity value is LD50 = 6 ug/ml||activity value is LD50 = 15 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00552	1796|||1948|||2100|||2252|||2404|||2547	FAKKLAKLALKLAKL	activity value is LD50 = 140 ug/ml||activity value is LD50 = 32 ug/ml||activity value is LD50 = 47 ug/ml||activity value is LD50 = 72 ug/ml||activity value is LD50 = 45 ug/ml	N/A	N/A	N/A	N/A	15	L
FPDB00553	1797|||1949|||2101|||2253|||2405|||2548|||2691	FAKKLAKKLAKLAL	activity value is LD50 = 260 ug/ml||activity value is LD50 = 180 ug/ml||activity value is LD50 = 160 ug/ml||activity value is LD50 = 330 ug/ml||activity value is LD50 = 170 ug/ml	N/A	N/A	N/A	N/A	14	L
FPDB00554	1798|||1950|||2102|||2254|||2406|||2549|||2692	FAKKLKKLAKLAKKL	activity value is LD50 = 300 ug/ml||activity value is LD50 = 160 ug/ml||activity value is LD50 = 150 ug/ml||activity value is LD50 = 290 ug/ml||activity value is LD50 = 280 ug/ml	N/A	N/A	N/A	N/A	15	L
FPDB00555	1799|||1951|||2103|||2255|||2407|||2550|||2693	FAKKALKALKKL	activity value is LD50 = 575 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 700 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00556	1800|||1952|||2104|||2256|||2408|||2551|||2694	VAKLLAKLAKKLL	activity value is LD50 = 23 ug/ml||activity value is LD50 = 47 ug/ml||activity value is LD50 = 43 ug/ml||activity value is LD50 = 17 ug/ml||activity value is LD50 = 32 ug/ml||activity value is LD50 = 44 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00557	1801|||1953|||2105|||2257|||2409|||2552|||2695	FAKLLAKLAKKL	activity value is LD50 = 40 ug/ml||activity value is LD50 = 100 ug/ml||activity value is LD50 = 115 ug/ml||activity value is LD50 = 140 ug/ml||activity value is LD50 = 77 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00558	1802|||1954|||2106|||2258|||2410|||2553|||2696	VAKKLAKLAKKLAKLAL	activity value is LD50 = 32 ug/ml||activity value is LD50 = 46 ug/ml||activity value is LD50 = 40 ug||activity value is LD50 = 54 ug/ml||activity value is LD50 = 7 ug/ml||activity value is LD50 = 33 ug/ml	N/A	N/A	N/A	N/A	17	L
FPDB00559	1803|||1955|||2107|||2259|||2411|||2554|||2697|||2878|||AP01007|||CAMPSQ1019|||CM	KWKLFKKIGAVLKVL	activity value is LD50 = 45 ug/ml||activity value is LD50 = 40 ug/ml||activity value is LD50 = 40 ug||activity value is LD50 = 65 ug/ml||activity value is LD50 = 30 ug/ml||LC50 = 1.75 uM||lethal concentration (LC): active against E. coli D21 (LC 1 uM)||P. aeruginosa OT97 (LC 4 uM)||B. subtilis (LC 0.5 uM)||B. megaterium (LC 0.7 uM)||S. aureus Cowan 1 (LC 2 uM)||and S. pyogenes (LC 0.5 uM).||Anti-E. coli D21, activity value is MIC = 1 uM||Anti-P. aeruginosa OT97, activity value is MIC = 4 uM||Anti-B. subtilis Bs11, activity value is MIC = 0.5 uM||Anti-B. megaterium Bm11, activity value is MIC = 0.7 uM||Anti-S. aureus Cowan 1, activity value is MIC = 2 uM||Anti-S. pyogenes, activity value is MIC = 0.5 uM||Anti-30043322 : A. baumannii ATCC 19606, activity value is MIC = 2 ug/ml||Anti-31448597: E. coli, activity value is MIC = 2 uM||Anti-E. coli, activity value is MIC = 2 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-K. pneumoniae, activity value is MIC = 16 uM||Anti-K. pneumoniae, activity value is MIC = 2 uM||Anti-P. aeruginosa, activity value is MIC = 2 uM||Anti-MRSA, activity value is MIC = 4 uM||Anti-S. aureus, activity value is MIC = 2 uM||Anti-Clostridioides difficile strain 630, activity value is MIC = 3.906	hybrid peptide, designed, man-made sequences|||Synthetic construct	Helix	Cecropin A: Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. Melittin: Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. CA(1-13)M(1-13): Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. CA(1-8)M(1-18): Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. CA(1-8)M(1-12): Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. CA(1-8)M(1-10): Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. CA(1-7)M(1-8): Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. CA(1-7)M(2-9): Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. CA(1-7)M(3-10): Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. CA(1-7)M(4-11): Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. CA(1-7)M(5-12): Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity. CA(1-7)M(6-13): Hemolytic value not explicitly given, but it is mentioned as having hemolytic activity.|||Sheep red cells ( LC > 300 uM ); Refer PubMed ID - 31448597: Mouse RBCs [Hemolysis (%) = 40 ± 5 uM]	FEBS Lett. 1992 Jan 20;296(2):190-4|||1733777, 30043322, 30720915, 31448597|||34516580	15	L
FPDB00560	1804|||1956|||2108|||2260|||2412|||2555|||2698	FAKLLAKLAKKAL	activity value is LD50 = 60 ug/ml||activity value is LD50 = 90 ug/ml||activity value is LD50 = 80 ug/ml||activity value is LD50 = 190 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00561	1805|||1957|||2109|||2261|||2413|||2556|||2699|||CAMPSQ19671|||HB55, FLAK50D AMD	FAKLLAKALKKLL	activity value is LD50 = 16 ug/ml||activity value is LD50 = 14 ug/ml||activity value is LD50 = 7 ug/ml||activity value is LD50 = 47 ug/ml||activity value is LD50 = 15 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 4 ug/ml||Anti-Salmonella enterica serovar Typhimurium, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M76, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa M917, activity value is MIC = 32 ug/ml||Anti-Pseudomonas aeruginosa M1251, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M1426, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa R70, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||Anti-Candida albicans, activity value is MIC = 16 ug/ml||Anti-Pseudomonas stutzeri, activity value is MIC = 8 ug/ml||Anti-Pseudomonas fluorescens, activity value is MIC = 16 ug/ml||Anti-Ralstonia pickettii, activity value is MIC = 16 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 2 ug/ml||Anti-Achromobacter xylosoxidans, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 5 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 5 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MFC = 25 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC = 4 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 10 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 4 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MFC = 25 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is LD50 = 16 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 14 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 16 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 7 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 = 15 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 47 ug/ml||Antibacterial||Antifungal	Synthetic construct	N/A	Human fibroblasts WI-38 (LD50 at 32 ug/ml	15980369	13	L
FPDB00562	1806|||1958|||2110|||2262|||2414|||2557|||2700	FAKLLKLAAKKLL	activity value is LD50 = 500 ug/ml||activity value is LD50 = 215 ug/ml||activity value is LD50 = 205 ug/ml||activity value is LD50 = 205 ug||activity value is LD50 = 370 ug/ml||activity value is LD50 = 435 ug/ml||activity value is LD50 = 300 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00563	1807|||1959|||2111|||2263|||2415|||2558|||2701	FAKLLAKKLL	LD50 =>1000 ug/ml||activity value is LD50 = 740 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 830 ug/ml	N/A	N/A	N/A	N/A	10	L
FPDB00564	1808|||1960|||2112|||2264|||2416|||2559|||2702	FAKKLAKALL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	10	L
FPDB00565	1809|||1961|||2113|||2265|||2417|||2560|||2703	FAKKLAKKLL	activity value is LD50 = 31 ug/ml||activity value is LD50 = 42 ug/ml||activity value is LD50 = 155 ug/ml||activity value is LD50 = 180 ug/ml||activity value is LD50 = 81 ug/ml	N/A	N/A	N/A	N/A	10	L
FPDB00566	1810|||1962|||2114|||2266|||2418|||2561|||2704	FAKLAKKLL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	9	L
FPDB00567	1813|||1965|||2117|||2269|||2421|||2564|||2707|||AP04088	FAKALKALLKALKAL	activity value is LD50 = 80 ug/ml||LD50 = ug/ml||activity value is LD50 = 35 ug/ml||activity value is LD50 = 30 ug/ml||activity value is LD50 = 46 ug/ml||Anti-E. coli, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa, activity value is MIC = 63 ug/ml||Anti-K. pneumonia, activity value is MIC = 63 ug/ml||Anti-E. faecium, activity value is MIC = 16 ug/ml||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-and C. acnes, activity value is MIC = 2 ug/ml	Commercial	N/A	N/A	Antibiotics (Basel). 2023 Mar 10;12(3):551. doi: 10.3390/antibiotics12030551. PubMed	15	L
FPDB00568	1814|||1966|||2118|||2270|||2422|||2565|||2708	FAKLLAKLAKAKL	activity value is LD50 = 475 ug/ml||activity value is LD50 = 345 ug/ml||activity value is LD50 = 250 ug/ml||activity value is LD50 = 450 ug/ml||activity value is LD50 = 470 ug/ml||activity value is LD50 = 210 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00569	1815|||1967|||2119|||2271|||2423|||2566|||2709	FAKLLAKLAKLKL	activity value is LD50 = 90 ug/ml||activity value is LD50 = 145 ug/ml||activity value is LD50 = 200 ug/ml||activity value is LD50 = 200 ug||activity value is LD50 = 130 ug/ml||activity value is LD50 = 170 ug/ml||activity value is LD50 = 140 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00570	1816|||1818|||1968|||1970|||2120|||2122|||2272|||2274|||2424|||2426|||2567|||2569|||2710|||2712	FAKKLAKKLKKLAKKLAKKWKL	activity value is LD50 = 44 ug/ml||activity value is LD50 = 93 ug/ml||activity value is LD50 = 11 ug/ml||activity value is LD50 = 82 ug/ml||activity value is LD50 = 94 ug/ml||activity value is LD50 = 290 ug/ml||activity value is LD50 = 290 ug||activity value is LD50 = 63 ug/ml||activity value is LD50 = 160 ug/ml||activity value is LD50 = 28 ug/ml||activity value is LD50 = 240 ug/ml	N/A	N/A	N/A	N/A	22	L
FPDB00571	1817|||1969|||2121|||2273|||2425|||2568|||2711|||HB71, Shiva 10	FAKKLAKKLKKLAKKLAK	activity value is LD50 = 190 ug/ml||activity value is LD50 = 250 ug/ml||activity value is LD50 = 445 ug||activity value is LD50 = 445 ug/ml||activity value is LD50 = 320 ug/ml||activity value is LD50 = 270 ug/ml||activity value is LD50 = 570 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 2 ug/ml||Anti-Salmonella enterica serovar Typhimurium, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa M76, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M917, activity value is MIC = 32 ug/ml||Anti-Pseudomonas aeruginosa M1251, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M1426, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa R70, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC > 128 ug/ml||Anti-Candida albicans, activity value is MIC = 32 ug/ml||Anti-Pseudomonas stutzeri, activity value is MIC = 2 ug/ml||Anti-Pseudomonas fluorescens, activity value is MIC = 8 ug/ml||Anti-Ralstonia pickettii, activity value is MIC = 4 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 1 ug/ml||Anti-Achromobacter xylosoxidans, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 15 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 15 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MFC = 200 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC = 50 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 40 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC > 50 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MFC > 50 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is LD50 = 190 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 250 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 445 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 320 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 = 570 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 270 ug/ml	Synthetic construct	N/A	Human fibroblasts WI-38 (LD50 at 355 ug/ml	15980369	18	L
FPDB00572	1819|||1826|||1971|||1978|||2123|||2130|||2275|||2282|||2427|||2434|||2570|||2577|||2713|||2720	KWKLFKKKTKLFKKFAKKLAKKL	activity value is LD50 = 150 ug/ml||activity value is LD50 = 63 ug/ml||activity value is LD50 = 70 ug/ml||activity value is LD50 = 13 ug/ml||activity value is LD50 = 360 ug||activity value is LD50 = 12 ug/ml||activity value is LD50 = 360 ug/ml||activity value is LD50 = 115 ug/ml||activity value is LD50 = 22 ug/ml||activity value is LD50 = 97 ug/ml||activity value is LD50 = 170 ug/ml||activity value is LD50 = 270 ug/ml||activity value is LD50 = 19 ug/ml	N/A	N/A	N/A	N/A	23	L
FPDB00573	1820|||1972|||2124|||2276|||2428|||2571|||2714	FAKKLAKKLAKAL	activity value is LD50 = 465 ug/ml||activity value is LD50 = 340 ug/ml||activity value is LD50 = 460 ug/ml||activity value is LD50 = 670 ug/ml||activity value is LD50 = 660 ug/ml||activity value is LD50 = 260 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00574	1821|||1973|||2125|||2277|||2429|||2572|||2715	FAKKLAKKLAKLL	activity value is LD50 = 42 ug/ml||activity value is LD50 = 17 ug/ml||activity value is LD50 = 24 ug/ml||activity value is LD50 = 80 ug/ml||activity value is LD50 = 54 ug/ml||activity value is LD50 = 74 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00575	1822|||1974|||2126|||2278|||2430|||2573|||2716	FAKKLAKKLAKAAL	activity value is LD50 = 970 ug/ml||activity value is LD50 = 400 ug/ml||activity value is LD50 = 750 ug||activity value is LD50 = 750 ug/ml||activity value is LD50 = 860 ug/ml||activity value is LD50 = 675 ug/ml||activity value is LD50 = 380 ug/ml	N/A	N/A	N/A	N/A	14	L
FPDB00576	1823|||1975|||2127|||2279|||2431|||2574|||2717	FAKKLAKKAKLAKKL	LD50 =>1000 ug/ml||activity value is LD50 = 125 ug||activity value is LD50 = 125 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	15	L
FPDB00577	1824|||1976|||2128|||2280|||2432|||2575|||2718	FAKKLKKLAKKL	activity value is LD50 = 540 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 830 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00578	1825|||1977|||2129|||2281|||2433|||2576|||2719	KTKLFKKFAKKLAKKLKKLAKKL	activity value is LD50 = 29 ug/ml||activity value is LD50 = 35 ug/ml||activity value is LD50 = 76 ug/ml||activity value is LD50 = 64 ug/ml||activity value is LD50 = 28 ug/ml||activity value is LD50 = 97 ug/ml	N/A	N/A	N/A	N/A	23	L
FPDB00579	1828|||1980|||2132|||2284|||2436|||2579|||2722	FAKALAKLAKKLL	activity value is LD50 = 23 ug/ml||activity value is LD50 = 51 ug/ml||activity value is LD50 = 46 ug/ml||activity value is LD50 = 25 ug/ml||activity value is LD50 = 83 ug/ml||activity value is LD50 = 670 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00580	1829|||1981|||2133|||2285|||2438|||2581|||2724	FAKLLALALKLKL	activity value is LD50 = 65 ug/ml||activity value is LD50 = 11 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00581	1830|||1982|||2134|||2286|||2439|||2582|||2725	FAKLLAKLAKAKA	LD50 =>1000 ug/ml||activity value is LD50 = 820 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00582	1831|||1983|||2135|||2287|||2440|||2583|||2726	FAKLLAKLAKAKG	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00583	1832|||1984|||2136|||2288|||2441|||2584|||2727	FAKKLAKKLKKLAKKLAKLALALKALALKAL	activity value is LD50 = 96 ug/ml||activity value is LD50 = 125 ug/ml||activity value is LD50 = 94 ug/ml||activity value is LD50 = 53 ug/ml||activity value is LD50 = 52 ug/ml||activity value is LD50 = 175 ug/ml	N/A	N/A	N/A	N/A	31	L
FPDB00584	1833|||1985|||2137|||2289|||2442|||2585|||2728	FAKKLAKKLKKLAKKLIGAVLKV	activity value is LD50 = 95 ug/ml||activity value is LD50 = 120 ug/ml||activity value is LD50 = 94 ug/ml||activity value is LD50 = 54 ug/ml||activity value is LD50 = 28 ug/ml||activity value is LD50 = 180 ug/ml	N/A	N/A	N/A	N/A	23	L
FPDB00585	1834|||1986|||2138|||2290|||2443|||2586|||2729	FAKLLAKALKLKL	activity value is LD50 = 250 ug/ml||activity value is LD50 = 170 ug/ml||activity value is LD50 = 160 ug/ml||activity value is LD50 = 340 ug/ml||activity value is LD50 = 730 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00586	1835|||1987|||2139|||2291|||2444|||2587|||2730	FAKLLAKALKKAL	activity value is LD50 = 60 ug/ml||activity value is LD50 = 57 ug/ml||activity value is LD50 = 60 ug||activity value is LD50 = 27 ug/ml||activity value is LD50 = 66 ug/ml||activity value is LD50 = 43 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00587	1836|||1988|||2140|||2292|||2445|||2588|||2731	FAKLLAKALKKL	activity value is LD50 = 46 ug/ml||activity value is LD50 = 90 ug/ml||activity value is LD50 = 75 ug/ml||activity value is LD50 = 150 ug/ml||activity value is LD50 = 330 ug/ml||activity value is LD50 = 70 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00588	1837|||1989|||2141|||2293|||2446|||2589|||2732|||CA	KWKLFKKALKKLKKALKKAL	activity value is LD50 = 11 ug/ml||activity value is LD50 = 54 ug/ml||activity value is LD50 = 100 ug/ml||activity value is LD50 = 52 ug/ml||activity value is LD50 = 18 ug/ml||activity value is LD50 = 130 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is EC50 = 5 uM||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 10 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MFC = 200 ug/ml||Anti-Human colon adenocarcinoma SW480, activity value is LD50 = 54 ug/ml||Anti-Human melanoma BMKC, activity value is LD50 = 100 ug/ml||Anti-Human lung carcinoma H1299, activity value is LD50 = 52 ug/ml||Anti-Human cervical carcinoma HeLa S3, activity value is LD50 = 130 ug/ml||Anti-Human prostate adenocarcinoma PC-3, activity value is LD50 = 18 ug/ml	Synthetic construct	N/A	Human erythrocytes (50% Hemolysis at 32 uM)|||Human erythrocytes (50% Hemolysis at 32 uM	29679519	20	L
FPDB00589	1838|||1990|||2142|||2294|||2447|||2590|||2733	KIAKVALAKLGIGAVLKVLTTGL	activity value is LD50 = 635 ug/ml||LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	23	L
FPDB00590	1839|||1991|||2143|||2295|||2448|||2591|||2734	FAKKLAKLAKKL	activity value is LD50 = 620 ug/ml||activity value is LD50 = 570 ug/ml||activity value is LD50 = 690 ug/ml||activity value is LD50 = 920 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 700 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00591	1840|||1992|||2144|||2296|||2449|||2592|||2735	MPKEKVFLKIEKMGRNIRN	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	19	L
FPDB00592	1842|||1994|||2146|||2298|||2451|||2594|||2737	FAKKLAKLAKKLAKAL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	16	L
FPDB00593	1843|||1995|||2147|||2299|||2452|||2595|||2738	FAKKLLAKALKL	activity value is LD50 = 180 ug/ml||activity value is LD50 = 325 ug/ml||activity value is LD50 = 400 ug/ml||activity value is LD50 = 95 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 540 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00594	1844|||1996|||2148|||2300|||2453|||2596|||2739	FAKFLAKFLKKAL	activity value is LD50 = 35 ug/ml||activity value is LD50 = 27 ug/ml||activity value is LD50 = 26 ug/ml||activity value is LD50 = 8 ug/ml||activity value is LD50 = 11 ug/ml||activity value is LD50 = 7 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00595	1845|||1997|||2149|||2301|||2454|||2597|||2740	FAKLLFKALKKAL	activity value is LD50 = 500 ug/ml||activity value is LD50 = 800 ug/ml||activity value is LD50 = 445 ug/ml||activity value is LD50 = 470 ug/ml||activity value is LD50 = 640 ug/ml||activity value is LD50 = 660 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00596	1846|||1998|||2150|||2302|||2455|||2598|||2741	FAKLLAKFLKKAL	activity value is LD50 = 150 ug/ml||activity value is LD50 = 180 ug/ml||activity value is LD50 = 115 ug/ml||activity value is LD50 = 50 ug/ml||activity value is LD50 = 240 ug/ml||activity value is LD50 = 190 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00597	1847|||1999|||2151|||2303|||2456|||2599|||2742	FAKLLAKAFKKAL	activity value is LD50 = 730 ug/ml||LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00598	1848|||2000|||2152|||2304|||2457|||2600|||2743	FAKLFAKAFKKAL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00599	1849|||2001|||2153|||2305|||2458|||2601|||2744	FAKLLAKALKKFL	activity value is LD50 = 70 ug/ml||activity value is LD50 = 115 ug/ml||activity value is LD50 = 135 ug/ml||activity value is LD50 = 74 ug/ml||activity value is LD50 = 330 ug/ml||activity value is LD50 = 87 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00600	1850|||2002|||2154|||2306|||2459|||2602|||2745	FAKLLAKALKKFAL	activity value is LD50 = 54 ug/ml||activity value is LD50 = 46 ug/ml||activity value is LD50 = 36 ug/ml||activity value is LD50 = 33 ug/ml||activity value is LD50 = 140 ug/ml||activity value is LD50 = 30 ug/ml	N/A	N/A	N/A	N/A	14	L
FPDB00601	1851|||2003|||2155|||2307|||2460|||2603|||2746	FAKLLAKLAKKFAL	activity value is LD50 = 730 ug/ml||activity value is LD50 = 630 ug/ml||activity value is LD50 = 660 ug/ml||activity value is LD50 = 620 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 810 ug/ml	N/A	N/A	N/A	N/A	14	L
FPDB00602	1852|||2004|||2156|||2308|||2461|||2604|||2747	FAKLFAKLAKKFAL	activity value is LD50 = 400 ug/ml||activity value is LD50 = 800 ug/ml||activity value is LD50 = 670 ug/ml||activity value is LD50 = 460 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 830 ug/ml	N/A	N/A	N/A	N/A	14	L
FPDB00603	1853|||2005|||2157|||2309|||2462|||2605|||2748	FKLAFKLAKKAFL	activity value is LD50 = 360 ug/ml||activity value is LD50 = 570 ug/ml||activity value is LD50 = 700 ug/ml||activity value is LD50 = 830 ug/ml||activity value is LD50 = 800 ug/ml||activity value is LD50 = 780 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00604	1854|||2006|||2158|||2310|||2463|||2606|||2749	FAKLLAKLAK	activity value is LD50 = 615 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 635 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 940 ug/ml	N/A	N/A	N/A	N/A	10	L
FPDB00605	1855|||2007|||2159|||2311|||2464|||2607|||2750	FAKLLAKLAKKVL	activity value is LD50 = 18 ug/ml||activity value is LD50 = 9 ug/ml||activity value is LD50 = 10 ug/ml||activity value is LD50 = 30 ug/ml||activity value is LD50 = 14 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00606	1856|||2008|||2160|||2312|||2465|||2608|||2751	FAKLLAKLAKKIL	activity value is LD50 = 90 ug||activity value is LD50 = 125 ug/ml||activity value is LD50 = 220 ug/ml||activity value is LD50 = 76 ug/ml||activity value is LD50 = 145 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00607	1857|||2009|||2161|||2313|||2466|||2609|||2752	FAKLLAKLAKKEL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00608	1858|||2010|||2162|||2314|||2467|||2610|||2753	FAKLLAKLAKKSL	activity value is LD50 = 440 ug/ml||activity value is LD50 = 400 ug/ml||activity value is LD50 = 535 ug/ml||activity value is LD50 = 770 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 610 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00609	1859|||2011|||2163|||2315|||2468|||2611|||2754	FAKLA	activity value is LD50 = 500 ug/ml||activity value is LD50 = 530 ug/ml||activity value is LD50 = 330 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 700 ug/ml	N/A	N/A	N/A	N/A	5	L
FPDB00610	1860|||2012|||2164|||2316|||2469|||2612|||2755	FAKLF	LD50 =>1000 ug/ml||activity value is LD50 = 550 ug/ml||activity value is LD50 = 790 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	5	L
FPDB00611	1861|||2013|||2165|||2317|||2470|||2613|||2756	KAKLF	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	5	L
FPDB00612	1862|||2166|||2318|||2471|||2614|||2757	KWKLF	activity value is LD50 = 600 ug/ml||LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	5	L
FPDB00613	1863|||2015|||2167|||2319|||2472|||2615|||2758	FGKGIGKVGKKLL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00614	1864|||2016|||2168|||2320|||2473|||2616|||2759	FAFGKGIGKVGKKLL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	15	L
FPDB00615	1865|||2017|||2169|||2321|||2474|||2617|||2760	FAKAIAKIAFGKGIGKVGKKLL	LD50 =>1000 ug/ml||activity value is LD50 = 740 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	22	L
FPDB00616	1866|||2018|||2170|||2322|||2475|||2618|||2761	FAKLWAKLAFGKGIGKVGKKLL	activity value is LD50 = 54 ug/ml||activity value is LD50 = 80 ug/ml||activity value is LD50 = 155 ug/ml||activity value is LD50 = 115 ug/ml||activity value is LD50 = 310 ug/ml||activity value is LD50 = 215 ug/ml	N/A	N/A	N/A	N/A	22	L
FPDB00617	1867|||2019|||2171|||2323|||2476|||2619|||2762	FAKLWAKLAKKL	activity value is LD50 = 500 ug/ml||activity value is LD50 = 600 ug/ml||activity value is LD50 = 530 ug/ml||activity value is LD50 = 450 ug/ml||activity value is LD50 = 900 ug/ml||activity value is LD50 = 400 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00618	1868|||2020|||2172|||2324|||2477|||2620|||2763	FAKGVGKVGKKAL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00619	1869|||2021|||2173|||2325|||2478|||2621|||2764	FAFGKGIGKIGKKGL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	15	L
FPDB00620	1870|||2022|||2174|||2326|||2479|||2622|||2765	FAKIIAKIAKIAKKIL	activity value is LD50 = 625 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 525 ug/ml||activity value is LD50 = 850 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	16	L
FPDB00621	1871|||2023|||2175|||2327|||2480|||2623|||2766	FAFAKIIAKIAKKII	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 285 ug/ml	N/A	N/A	N/A	N/A	15	L
FPDB00622	1872|||2024|||2176|||2328|||2481|||2624|||2767	FALALKA	activity value is LD50 = 430 ug/ml||activity value is LD50 = 560 ug/ml||activity value is LD50 = 465 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	7	L
FPDB00623	1873|||2025|||2177|||2329|||2482|||2625|||2768	KWKLAKKALALL	activity value is LD50 = 44 ug/ml||activity value is LD50 = 38 ug/ml||activity value is LD50 = 115 ug/ml||activity value is LD50 = 60 ug/ml||activity value is LD50 = 55 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00624	1874|||2026|||2178|||2330|||2483|||2626|||2769	FAKIIAKIAKKI	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00625	1875|||2027|||2179|||2331|||2484|||2627|||2770	FALALKALKKAL	activity value is LD50 = 150 ug/ml||activity value is LD50 = 285 ug/ml||activity value is LD50 = 250 ug/ml||activity value is LD50 = 225 ug/ml||activity value is LD50 = 350 ug/ml||activity value is LD50 = 275 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00626	1876|||2028|||2180|||2332|||2485|||2628|||2771	FALKALKK	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 240 ug/ml	N/A	N/A	N/A	N/A	8	L
FPDB00627	1877|||2029|||2181|||2333|||2486|||2629|||2772|||SB1	KYKKALKKLAKLL	activity value is LD50 = 110 ug/ml||activity value is LD50 = 380 ug/ml||activity value is LD50 = 185 ug/ml||activity value is LD50 = 93 ug/ml||activity value is LD50 = 440 ug/ml||activity value is LD50 = 640 ug/ml||Anti-P. aeruginosa, activity value is MIC = 2 ug/ml	Synthetic construct	N/A	N/A	30830745	13	L
FPDB00628	1878|||2030|||2182|||2334|||2487|||2630|||2773	FKRLAKIKVLRLAKIKR	activity value is LD50 = 106 ug/ml||activity value is LD50 = 185 ug/ml||activity value is LD50 = 110 ug/ml||activity value is LD50 = 93 ug/ml||activity value is LD50 = 340 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	17	L
FPDB00629	1879|||2031|||2183|||2335|||2488|||2631|||2774	FAKLAKKALAKLL	activity value is LD50 = 315 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 330 ug/ml||activity value is LD50 = 660 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00630	1880|||2032|||2184|||2336|||2489|||2632|||2775	KAKLAKKALAKLL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00631	1881|||2033|||2185|||2337|||2490|||2633|||2776	KLALKLALKALKAAKLA	activity value is LD50 = 160 ug/ml||activity value is LD50 = 235 ug/ml||activity value is LD50 = 190 ug/ml||activity value is LD50 = 185 ug/ml||activity value is LD50 = 74 ug/ml||activity value is LD50 = 320 ug/ml	N/A	N/A	N/A	N/A	17	L
FPDB00632	1882|||2034|||2186|||2338|||2491|||2634|||2777	FAKLLAKLAKK	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	11	L
FPDB00633	1883|||2035|||2187|||2339|||2492|||2635|||2778	FAKLLAKLAKKGL	activity value is LD50 = 430 ug/ml||activity value is LD50 = 740 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 410 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00634	1884|||2036|||2188|||2340|||2493|||2636|||2779|||HB153	FALKALKKLKKALKKAL	activity value is LD50 = 64 ug/ml||activity value is LD50 = 61 ug/ml||activity value is LD50 = 165 ug/ml||activity value is LD50 = 50 ug/ml||activity value is LD50 = 97 ug/ml||activity value is LD50 = 140 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 4 ug/ml||Anti-Salmonella enterica serovar Typhimurium, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M76, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa M917, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa M1251, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M1426, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa R70, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||Anti-Candida albicans, activity value is MIC = 16 ug/ml||Anti-Pseudomonas stutzeri, activity value is MIC = 4 ug/ml||Anti-Pseudomonas fluorescens, activity value is MIC = 4 ug/ml||Anti-Ralstonia pickettii, activity value is MIC = 4 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 4 ug/ml||Anti-Achromobacter xylosoxidans, activity value is MIC = 128 ug/ml	Synthetic construct	N/A	N/A	15980369	17	L
FPDB00635	1885|||2037|||2189|||2341|||2494|||2637|||2780	VAKLLAKLAKKVL	activity value is LD50 = 315 ug/ml||activity value is LD50 = 750 ug/ml||activity value is LD50 = 330 ug/ml||activity value is LD50 = 400 ug/ml||activity value is LD50 = 640 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00636	1886|||2038|||2190|||2342|||2495|||2638|||2781	YAKLLAKLAKKAL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00637	1887|||2039|||2191|||2343|||2496|||2639|||2782	KLLKLLLKLYKKLLKLL	activity value is LD50 = 135 ug/ml||activity value is LD50 = 345 ug/ml||activity value is LD50 = 520 ug/ml||activity value is LD50 = 600 ug/ml||activity value is LD50 = 260 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	17	L
FPDB00638	1888|||2040|||2192|||2344|||2497|||2640|||2783|||DRAMP31191|||D5F|||DRAMP31191	FAVGLRAIKRALKKLRRGVRKVAKDL	activity value is LD50 = 240 ug/ml||activity value is LD50 = 530 ug/ml||activity value is LD50 = 600 ug/ml||activity value is LD50 = 315 ug/ml||activity value is LD50 = 375 ug/ml||LD50 = >1000 ug/ml||Anti-Feline immunodeficiency virus :inhibition of reverse transcriptase activity in CrFK cells, activity value is IC50 = 5.47 uM||Anti-Feline immunodeficiency virus, activity value is IC50 = 5.47 uM||Antimicrobial||Antiviral	Synthetic construct	N/A	N/A	Ref.12208971|||https://pubmed.ncbi.nlm.nih.gov/12208971|||J Virol. 2002 Oct;76(19):9952-61.	26	L
FPDB00639	1889|||1890|||2041|||2042|||2193|||2194|||2345|||2346|||2498|||2499|||2641|||2642|||2784|||2785|||Modelin-5-CONH2	KLAKKLAKLAKLAKAL	activity value is LD50 = 61 ug/ml||activity value is LD50 = 320 ug/ml||activity value is LD50 = 140 ug/ml||activity value is LD50 = 370 ug/ml||activity value is LD50 = 220 ug/ml||activity value is LD50 = 74 ug/ml||activity value is LD50 = 470 ug/ml||activity value is LD50 = 145 ug/ml||activity value is LD50 = 450 ug/ml||activity value is LD50 = 275 ug/ml||activity value is LD50 = 550 ug/ml	Synthetic construct	N/A	N/A	31074477	16	L
FPDB00640	1891|||2195|||2347|||2500|||2643|||2786	FALALKALKKL	activity value is LD50 = 360 ug/ml||activity value is LD50 = 240 ug/ml||activity value is LD50 = 56 ug/ml||activity value is LD50 = 340 ug/ml||activity value is LD50 = 400 ug/ml	N/A	N/A	N/A	N/A	11	L
FPDB00641	1892|||2044|||2196|||2348|||2501|||2644|||2787	FALAKALKKAL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml	N/A	N/A	N/A	N/A	11	L
FPDB00642	1893|||2045|||2197|||2349|||2502|||2645|||2788	FALALKLAKKAL	activity value is LD50 = 230 ug/ml||activity value is LD50 = 360 ug/ml||activity value is LD50 = 240 ug/ml||activity value is LD50 = 300 ug/ml||activity value is LD50 = 320 ug/ml||activity value is LD50 = 325 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00643	1894|||2046|||2198|||2350|||2503|||2646|||2789	FALLKL	activity value is LD50 = 630 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 590 ug||activity value is LD50 = 590 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	6	L
FPDB00644	1895|||2047|||2199|||2351|||2504|||2647|||2790	FALALKALKK	activity value is LD50 = 510 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 530 ug/ml||activity value is LD50 = 640 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	10	L
FPDB00645	1896|||2048|||2200|||2352|||2505|||2648|||2791	FALKALKKAL	activity value is LD50 = 940 ug/ml||LD50 =>1000 ug/m||LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	10	L
FPDB00646	1897|||2049|||2201|||2353|||2506|||2649|||2792	FALLKALKKAL	activity value is LD50 = 305 ug/ml||activity value is LD50 = 770 ug/ml||activity value is LD50 = 600 ug/ml||activity value is LD50 = 540 ug/ml||activity value is LD50 = 820 ug/ml	N/A	N/A	N/A	N/A	11	L
FPDB00647	1898|||2050|||2202|||2354|||2507|||2650|||2793	KFKKLAKKF	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	9	L
FPDB00648	1899|||2051|||2203|||2355|||2508|||2651|||2794	KFKKLAKKW	LD50 =>1000 ug/ml||activity value is LD50 = 70 ug||LD50 =>1000 ug/ml||activity value is LD50 = 510 ug/ml	N/A	N/A	N/A	N/A	9	L
FPDB00649	1900|||2052|||2204|||2356|||2509|||2652|||2795	FALALKALKKA	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	11	L
FPDB00650	1901|||2053|||2205|||2357|||2510|||2653|||2796	FALLKALLKKAL	activity value is LD50 = 190 ug/ml||activity value is LD50 = 310 ug/ml||activity value is LD50 = 240 ug/ml||activity value is LD50 = 120 ug/ml||activity value is LD50 = 380 ug/ml	N/A	N/A	N/A	N/A	12	L
FPDB00651	1902|||2054|||2206|||2358|||2511|||2654|||2797	FALALKLAKKL	activity value is LD50 = 770 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 640 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	11	L
FPDB00652	1903|||2055|||2207|||2359|||2512|||2655|||2798	LKKLAKLALAF	activity value is LD50 = 555 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 920 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	11	L
FPDB00653	1904|||2056|||2208|||2360|||2513|||2656|||2799	VALALKALKKL	activity value is LD50 = 950 ug/ml||activity value is LD50 = 600 ug/ml||activity value is LD50 = 770 ug/ml||LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 760 ug/ml	N/A	N/A	N/A	N/A	11	L
FPDB00654	1905|||2057|||2209|||2361|||2514|||2657|||2800	FALALKLKKL	activity value is LD50 = 550 ug/ml||activity value is LD50 = 870 ug/ml||activity value is LD50 = 830 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	10	L
FPDB00655	1906|||2058|||2210|||2362|||2515|||2658|||2801	FALALKAKKL	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	10	L
FPDB00656	1907|||2059|||2211|||2363|||2516|||2659|||2802	FALA	LD50 =>1000 ug/ml||LD50 =>1000 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	4	L
FPDB00657	1908|||2060|||2212|||2364|||2517|||2660|||2803	WALAL	activity value is LD50 = 260 ug/ml||activity value is LD50 = 440 ug/ml||activity value is LD50 = 600 ug/ml||activity value is LD50 = 370 ug/ml||activity value is LD50 = 570 ug/ml||activity value is LD50 = 302 ug/ml	N/A	N/A	N/A	N/A	5	L
FPDB00658	1910|||2062|||2214|||2366|||2519|||2662|||2805|||D2A21	FAKKFAKKFKKFAKKFAKFAFAF	activity value is LD50 = 64 ug/ml||activity value is LD50 = 76 ug/ml||activity value is LD50 = 140 ug/ml||activity value is LD50 = 77 ug/ml||activity value is LD50 = 45 ug/ml||activity value is LD50 = 170 ug/ml||Antibacterial||Anti-Feline immunodeficiency virus, activity value is IC50 = 3.05 uM	Synthetic construct	N/A	Human erythrocytes (93.1% Hemolysis at 250 ug/ml, Feline kidney epithelial CRFK cells (50% Cytotoxicity at 3.43 uM	11751108, 32204024|||12208971	23	L
FPDB00659	1911|||2063|||2215|||2367|||2520|||2663|||2806|||KSL	KKVVFKVKFK	activity value is LD50 = 340 ug/ml||LD50 =>1000 ug/ml||activity value is LD50 = 700 ug/ml||activity value is LD50 = 720 ug/ml||LD50 =>1000 ug/ml||Anti-Xanthomonas arboricola pv. Pruni, activity value is MIC = 6.2||Anti-Xanthonomas axonopodis pv. vesicatoria, activity value is MIC = 12.5||Anti-Xanthomonas fragariae, activity value is MIC = 6.2||Anti-Pseudomonas syringae pv. Actinidiae, activity value is MIC = 1.6||Anti-Pseudomonas syringae pv. syringae, activity value is MIC = 6.2	Synthetic construct	N/A	Horse blood cells(5 ± 1.3% hemolysis at 375 uM)	30508634	10	L
FPDB00660	1912|||2064|||2216|||2368|||2521|||2664|||2807|||KSL7	FKVKFKVKVK	activity value is LD50 = 315 ug/ml||activity value is LD50 = 530 ug/ml||activity value is LD50 = 330 ug/ml||activity value is LD50 = 345 ug/ml||LD50 =>1000 ug/ml||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 9 ug/ml||Anti-Micrococcus luteus ATCC 9341, activity value is MIC = 5 ug/ml||Anti-Staphylococcus aureus 1550, activity value is MIC = 11 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 6 ug/ml||Anti-Escherichia coli ATCC 2592, activity value is MIC = 12.5 ug/ml||Anti-Candida albicans ATCC 36232, activity value is MIC = 6.25 ug/ml||Anti-Candida albicans ATCC 36232, activity value is MIC = 10 ug/ml	Synthetic construct	N/A	N/A	10195440|||https://pubmed.ncbi.nlm.nih.gov/10195440	10	L
FPDB00661	1913|||2065|||2217|||2369|||2522|||2665|||2808	LPKWKVFKKIEKVGRNIRNGIVKAGPAIAVLGEAKALG	activity value is LD50 = 50 ug/ml||activity value is LD50 = 240 ug/ml||activity value is LD50 = 170 ug/ml||activity value is LD50 = 120 ug/ml||activity value is LD50 = 370 ug/ml||activity value is LD50 = 250 ug/ml	N/A	N/A	N/A	N/A	38	L
FPDB00662	1914|||2066|||2218|||2370|||2523|||2666|||2809	FAKKLAKKLKKLAKKLAKLAKKL	activity value is LD50 = 38 ug/ml||activity value is LD50 = 73 ug/ml||activity value is LD50 = 83 ug/ml||activity value is LD50 = 160 ug/ml||activity value is LD50 = 66 ug/ml||activity value is LD50 = 100 ug/ml	N/A	N/A	N/A	N/A	23	L
FPDB00663	1916|||2068|||2220|||2372	VAKFLAKFLKKAL	activity value is LD50 = 92 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00664	1917|||2069|||2221|||2373	VAKKFAKKFKKFAKKFAKFAFAF	activity value is LD50 = 210 ug/ml	N/A	N/A	N/A	N/A	23	L
FPDB00665	1918|||2222|||2374|||HB504	VAKKLAKLAKKLAKLALAL	activity value is LD50 = 130 ug/ml||Antibacterial ; Synthetic construct||Anti-Escherichia coli UB1005, activity value is MIC = 64 ug/ml||Anti-Salmonella enterica serovar Typhimurium, activity value is MIC = 64 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 32 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M76, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M917, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa M1251, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa M1426, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa R70, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 32 ug/ml||Anti-Candida albicans, activity value is MIC = 16 ug/ml||Anti-Pseudomonas stutzeri, activity value is MIC = 4 ug/ml||Anti-Pseudomonas fluorescens, activity value is MIC = 8 ug/ml||Anti-Ralstonia pickettii, activity value is MIC = 8 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 4 ug/ml||Anti-Achromobacter xylosoxidans, activity value is MIC = 64 ug/ml	Synthetic construct	N/A	Escherichia coli UB1005[MIC = 64 ug/ml], Salmonella enterica serovar Typhimurium[MIC = 64 ug/ml], Pseudomonas aeruginosa PAO1[MIC = 32 ug/ml], Pseudomonas aeruginosa[MIC = 8 ug/ml], Pseudomonas aeruginosa[MIC = Aug-16 ug/ml], Pseudomonas aeruginosa M76[MIC = 8 ug/ml], Pseudomonas aeruginosa M917[MIC = 16 ug/ml], Pseudomonas aeruginosa M1251[MIC = 8 ug/ml], Pseudomonas aeruginosa M1426[MIC = 8 ug/ml], Pseudomonas aeruginosa R70[MIC = 8 ug/ml], Staphylococcus aureus[MIC = 32 ug/ml], Candida albicans[MIC = 16 ug/ml], Pseudomonas stutzeri[MIC = 4 ug/ml], Pseudomonas fluorescens[MIC = 8 ug/ml], Ralstonia pickettii[MIC = 8 ug/ml], Stenotrophomonas maltophilia[MIC = 4 ug/ml], Achromobacter xylosoxidans[MIC = 64 ug/ml]	https://pubmed.ncbi.nlm.nih.gov/15980369|||15980369	19	L
FPDB00666	1919|||2223|||2375	VAKKLAKLAKKLLAL	activity value is LD50 = 86 ug/ml	N/A	N/A	N/A	N/A	15	L
FPDB00667	1920|||2072|||2224|||2376	VAKLLAKALKKLL	activity value is LD50 = 45 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00668	1923|||2379	VALALKALKKLAKKLKKLAKKAL	activity value is LD50 = 84 ug/ml	N/A	N/A	N/A	N/A	23	L
FPDB00669	1924|||2076|||2228|||2380|||2437|||2580|||2723	FAKLLAKLAKKAA	activity value is LD50 = 320 ug/ml||activity value is LD50 = 690 ug/ml||LD50 = >1000 ug/ml	N/A	N/A	N/A	N/A	13	L
FPDB00670	1942|||2071|||2094|||2246|||2398|||2541|||2684	FAKKLAKLAKKLLAL	activity value is LD50 = 13 ug/ml||activity value is LD50 = 21 ug/ml||activity value is LD50 = 33 ug/ml||activity value is LD50 = 10 ug/ml||activity value is LD50 = 35 ug/ml	N/A	N/A	N/A	N/A	15	L
FPDB00671	2043	KWKKLAKKW	activity value is LD50 = 240 ug/ml	N/A	N/A	N/A	N/A	9	L
FPDB00672	2219	VAKALKALLKALKAL	N/A	N/A	N/A	N/A	N/A	15	L
FPDB00673	2371	VAKALAKALLKALKAL	N/A	N/A	N/A	N/A	N/A	16	L
FPDB00674	2810|||2812|||2814|||2816|||2818|||2820|||2822|||2824|||2826|||2828|||2830|||2832|||2834|||DRAMP31825	RRRRRNWMWC	activity value is IC50 = 44 uM||activity value is IC50 = 23 uM||activity value is IC50 = 28 uM||activity value is IC50 = 39 uM||activity value is IC50 = 29 uM||activity value is IC50 = 16 uM||activity value is IC50 = 93 uM||activity value is IC50 = 37 uM||activity value is IC50 = 36 uM||activity value is IC50 = 25 uM||activity value is IC50 = 47 uM||activity value is IC50 = 12 uM||Antimicrobial||Anticancer	Nullomer derived anticancer peptides (NulloPs):	N/A	no hemolytic effect on human RBCs	Peptides. 2012 Dec;38(2):302-11.	10	L
FPDB00675	2811|||2813|||2815|||2817|||2819|||2821|||2823|||2825|||2827|||2829|||2831|||2833|||2835|||DRAMP31826	RRRRRWCMNW	activity value is IC50 = 26 uM||activity value is IC50 = 9 uM||activity value is IC50 = 8 uM||activity value is IC50 = 18 uM||activity value is IC50 = 12 uM||activity value is IC50 = 10 uM||activity value is IC50 = 38 uM||activity value is IC50 = 43 uM||activity value is IC50 = 45 uM||activity value is IC50 = 36 uM||activity value is IC50 = 17 uM||Antimicrobial||Anticancer	Nullomer derived anticancer peptides (NulloPs):	N/A	significant hemolytic activity	Peptides. 2012 Dec;38(2):302-11.	10	L
FPDB00676	2839|||2842|||AP04801|||Undefined|||DRAMP31833	GIIKKIIKKI	99% Cytotoxicity at 4 uM Approx||100% Cytotoxicity at 5 uM Approx||Anti-S.aureus ATCC 25923, activity value is MIC > 128 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 16 uM||Anti-K.pneumoniae ATCC 700603, activity value is MIC > 128 uM||Anti-E. coli ATCC 25922, activity value is MIC = 32 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 64 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 64 uM||Anti-Escherichia coli DH5alpha, activity value is MIC = 125||Anti-Bacillus subtilis 168, activity value is MIC = 30||Anti-Human cervical carcinoma HeLa, activity value is IC50 = 160||Anti-Human promyelocytic leukemia HL-60, activity value is IC50 > 500 uM||Antimicrobial||Anticancer	Designed, man-made sequences|||Synthetic construct|||Alpha-helical proteins	Helix	hRBC: HC10 >256 uM; HC50> 256 uM, not hemo.lytic. LC50 >128 uM not toxic to human embryonic kidney cell line (HEK293T)|||Human erythrocytes (- at NA	ACS Infect Dis. 2024 Aug 14. doi: 10.1021/acsinfecdis.3c00706. PubMed|||21955251|||Biomaterials. 2014 Feb;35(5):1552-61.	10	L
FPDB00677	2840|||2843|||AP04802|||G|||DRAMP31834	GIIKKIIKKIIKKI	95% Cytotoxicity at 4 uM Approx||90% Cytotoxicity at 5 uM Approx||Anti-S. aureus ATCC 25923, activity value is MIC = 4 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 8 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 8 uM||Anti-E. coli ATCC 25922, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 8 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 4 uM||Antifungal||Antibiofilm||Antimicrobial||Anticancer	Designed, man-made sequences|||Synthetic construct|||Alpha-helical proteins	Helix	hRBC: HC10 138.32 uM. HC50 256 uM. poorly hemo.lytic. LC50 16 uM toxic to human embryonic kidney cell line (HEK293T).|||Human erythrocytes (HC50 >800 uM)|||Human erythrocytes: HC50>250 uM	ACS Infect Dis. 2024 Aug 14. doi: 10.1021/acsinfecdis.3c00706. PubMed|||34626966|||Biomaterials. 2014 Feb;35(5):1552-61.	14	L
FPDB00678	2841|||2844|||AP04803|||Undefined|||DRAMP31835	GIIKKIIKKIIKKIIKKI	80% Cytotoxicity at 4 uM Approx||70% Cytotoxicity at 5 uM Approx||Anti-S. aureus ATCC 25923, activity value is MIC = 4 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 2 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 8 uM||Anti-E. coli ATCC 25922, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 4 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 4 uM||Anti-Escherichia coli DH5alpha, activity value is MIC = 2||Anti-Bacillus subtilis 168, activity value is MIC = 0.5||Anti-Human cervical carcinoma HeLa, activity value is IC50 = 4||Anti-Human promyelocytic leukemia HL-60, activity value is IC50 = 10||Antimicrobial||Anticancer	Designed, man-made sequences|||Synthetic construct|||Alpha-helical proteins	Helix	hRBC: HC10 6.887 uM. HC50 32 uM. hemolytic. LC50 4-8 uM toxic to human embryonic kidney cell line (HEK293T).|||Human erythrocytes (50% Hemolysis at 41+-2 uM	ACS Infect Dis. 2024 Aug 14. doi: 10.1021/acsinfecdis.3c00706. PubMed|||21955251|||Biomaterials. 2014 Feb;35(5):1552-61.	18	L
FPDB00679	2845|||DRAMP31616	ERRP	30% Cell viability at 5 ug/ml||Antimicrobial||Anticancer	EGFR-related peptide	N/A	N/A	Mol Cancer Ther. 2004 Dec;3(12):1615-21.	4	L
FPDB00680	2872|||2873|||2874|||DRAMP35103	DEVD	65% Cell viability at 20 uM||40% Cell viability at 20 uM||35 % Cell viability at 40 uM||Antimicrobial||Anticancer	N/A	N/A	N/A	Life Sci. 2013 May 30;92(20-21):1004-14.	4	L
FPDB00681	2900	MNFNKLFVFVALVLAVCIGQSEAGWLKKIGKKIERVGQHTRDATIQTIGVAQQAANVAATLKG	35.2 % Cell viability at 100 uM	N/A	N/A	N/A	N/A	63	L
FPDB00682	2973|||2974|||2975|||2976|||2977|||2978|||2979|||2980|||2981|||2982|||2983|||2984|||2985|||2986|||2987|||2988|||2989|||2990|||2991|||2992|||2993|||2994|||2995|||Epinecidin-1|||DRAMP21242	FIFHIIKGLFHAGKMI	8 % Cytotoxicity at 12.5 ug/ml||3 % Cytotoxicity at 6.25 ug/ml||3 % Cytotoxicity at 3.125 ug/ml||60 % Cytotoxicity at 50 ug/ml||50 % Cytotoxicity at 25 ug/ml||10 % Cytotoxicity at 6.25 ug/ml||5 % Cytotoxicity at 3.125 ug/ml||75 % Cytotoxicity at 50 ug/ml||70 % Cytotoxicity at 25 ug/ml||5 %Cytotoxicity at 12.5 ug/ml||7 % Cytotoxicity at 6.25 ug/ml||10 % Cytotoxicity at 3.125 ug/ml||76 % Cytotoxicity at 50 ug/ml||12 % Cytotoxicity at 12.5 ug/ml||4 % Cytotoxicity at 6.25 ug/ml||4 % Cytotoxicity at 3.125 ug/ml||90 % Cytotoxicity at 50 ug/ml||75 % Cytotoxicity at 25 ug/ml||Anti-Vibrio alginolyticus, activity value is MIC = 12.5 ug/ml||Anti-Vibrio harveyi BCRC 13812, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus BCRC 10780, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus sp. BCRC 10451, activity value is MIC = 12.5 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus sp, activity value is MIC = 12.5 ug/ml||Anti-##Gram-negative bacteria : Grouper Vibrio alginolyticus, activity value is MIC = 12.5 ug/ml||Anti-Vibrio harveyi, activity value is MIC = 6.25 ug/ml	Synthetic construct	N/A	Sheep erythrocytes (50% Hemolysis at 400 ug/ml|||[Ref.23598079] 0% hemolysis at 50 ug/ml , 10% hemolysis at 100 ug/ml , 20% hemolysis at 200 ug/ml , 50% hemolysis at 400 ug/ml against sheep red blood cells	23598079|||Peptides. 2013 Jun;44:139-48. doi: 10.1016/j.peptides.2013.04.004.||Ref.23598079	16	L
FPDB00683	3032|||3033|||3034|||3035|||3036|||3037|||3038|||3039|||3040|||3041|||3042|||3043|||3044|||3045|||3046|||3047|||3048|||3049|||3050|||3051|||3052|||3053|||3054|||3055|||3056|||3057|||3058|||3059|||3060|||3061|||3062|||3063|||3064|||3065|||3066|||3067|||3068|||3069|||3070|||3071|||Pardaxin P-4|||DRAMP21243	GFFALIPKIISSPLFKTLLSAVGSALS	70 % Cytotoxicity at 50 ug/ml||60 % Cytotoxicity at 25 ug/ml||4 % Cytotoxicity at 12.5 ug/ml||5 % Cytotoxicity at 6.25 ug/ml||1 % Cytotoxicity at 3.125 ug/ml||78 % Cytotoxicity at 50 ug/ml||70 % Cytotoxicity at 25 ug/ml||10 % Cytotoxicity at 12.5 ug/ml||10 % Cytotoxicity at 6.25 ug/ml||5 % Cytotoxicity at 3.125 ug/ml||82 % Cytotoxicity at 50 ug/ml||18 % Cytotoxicity at 12.5 ug/ml||4 % Cytotoxicity at 6.25 ug/ml||10 % Cytotoxicity at 3.125 ug/ml||90 % Cytotoxicity at 50 ug/ml||82 % Cytotoxicity at 25 ug/ml||18 % Cytotoxicity at 6.25 ug/ml||18 % Cytotoxicity at 3.125 ug/ml||80 % Cytotoxicity at 50 ug/ml||85 % Cytotoxicity at 25 ug/ml||45 % Cytotoxicity at 12.5 ug/ml||30 % Cytotoxicity at 6.25 ug/ml||25 % Cytotoxicity at 3.125 ug/ml||84 % Cytotoxicity at 50 ug/ml||84% Cytotoxicity at 25 ug/ml||48 % Cytotoxicity at 12.5 ug/ml||35 % Cytotoxicity at 3.125 ug/ml||30 % Cytotoxicity at 12.5 ug/ml||35 % Cytotoxicity at 6.25 ug/ml||15 % Cytotoxicity at 3.125 ug/ml||90 % Cytotoxicity at 25 ug/ml||20 % Cytotoxicity at 12.5 ug/ml||1 % Cytotoxicity at 6.25 ug/ml||Anti-Vibrio alginolyticus, activity value is MIC = 12.5 ug/ml||Anti-Vibrio harveyi BCRC 13812, activity value is MIC = 12.5 ug/ml||Anti-Vibrio vulnificus 204, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus BCRC 11034, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus BCRC 10780, activity value is MIC = 50 ug/ml||Anti-Streptococcus pneumoniae BCRC 10794, activity value is MIC = 50 ug/ml||Anti-Streptococcus agalactiae, activity value is MIC = 50 ug/ml||Anti-Staphylococcus sp. BCRC 10451, activity value is MIC = 6.25 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 12.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 50 ug/ml||Anti-Staphylococcus sp, activity value is MIC = 6.25 ug/ml||Anti-##Gram-negative bacteria : Grouper Vibrio alginolyticus, activity value is MIC = 12.5 ug/ml||Anti-Vibrio harveyi, activity value is MIC = 12.5 ug/ml||Anti-Vibrio vulnificus, activity value is MIC = 50 ug/ml	Synthetic construct	N/A	Sheep erythrocytes (50% Hemolysis at 100 ug/ml|||[Ref.23598079] 8% hemolysis at 12.5 ug/ml , 29% hemolysis at 25 ug/ml , 38% hemolysis at 50 ug/ml , 57.5% hemolysis at 100 ug/ml , 99% hemolysis at 200 ug/ml , 98% hemolysis at 400 ug/ml against sheep red blood cells	23598079|||Peptides. 2013 Jun;44:139-48. doi: 10.1016/j.peptides.2013.04.004.||Ref.23598079	27	L
FPDB00684	3073|||3079|||3085|||3091|||3097|||DRAMP31628	MWKWFHNVLSSWQLLADKRPARDYNRK	activity value is IC50 = 50 uM||activity value is IC50 = 53 uM||activity value is IC50 = 47 uM||activity value is IC50 = 37 uM||activity value is IC50 = 55 uM||Antimicrobial||Anticancer	S. pneumoniae	N/A	Human RBCs(0% hemolysis at 0.19 uM, 0.39 uM, 0.78 uM, 1.56 uM, 3.12 uM, 6.25 uM, 12.5 uM)	Cancer Cell Int. 2005 Jul 11;5:21.	27	L
FPDB00685	3074|||3080|||3086|||3092|||3098|||DRAMP31629	MWKWFHNVLSWWWLLADKRPARDYNRK	activity value is IC50 = 29 uM||activity value is IC50 = 20 uM||activity value is IC50 = 23 uM||activity value is IC50 = 25 uM||IC50= <10 uM||Antimicrobial||Anticancer	S. pneumoniae	N/A	Human RBCs(18% hemolysis at 12.5 uM), Human RBCs(0% hemolysis at 0.19 uM, 0.39 uM, 0.78 uM, 1.56 uM, 3.12 uM, 6.25 uM)	Cancer Cell Int. 2005 Jul 11;5:21.	27	L
FPDB00686	3075|||3081|||3087|||3093|||3099|||DRAMP31630	MRKWFHNVLSSGQLLADKWPAWDYNRK	activity value is IC50 = 67 uM||activity value is IC50 = 52 uM||activity value is IC50 = 50 uM||activity value is IC50 = 38 uM||Antimicrobial||Anticancer	S. pneumoniae	N/A	Human RBCs(0% hemolysis at 0.19 uM, 0.39 uM, 0.78 uM, 1.56 uM, 3.12 uM, 6.25 uM, 12.5 uM)	Cancer Cell Int. 2005 Jul 11;5:21.	27	L
FPDB00687	3076|||3082|||3088|||3094|||3100|||DRAMP31631	MWKEFHNVLSSGQLLADKRWARWYNRW	activity value is IC50 = 50 uM||activity value is IC50 = 51 uM||activity value is IC50 = 46 uM||activity value is IC50 = 37 uM||activity value is IC50 = 29 uM||Antimicrobial||Anticancer	S. pneumoniae	N/A	Human RBCs(0% hemolysis at 0.19 uM, 0.39 uM, 0.78 uM, 1.56 uM, 3.12 uM, 6.25 uM, 12.5 uM)	Cancer Cell Int. 2005 Jul 11;5:21.	27	L
FPDB00688	3077|||3083|||3089|||3095|||3101|||DRAMP31632	MWKWFHNVLSSGQLLADKWWAWWYNWW	IC50= >70 uM||IC50=>70 uM||Antimicrobial||Anticancer	S. pneumoniae	N/A	Human RBCs(0% hemolysis at 0.19 uM, 0.39 uM, 0.78 uM, 1.56 uM, 3.12 uM, 6.25 uM, 12.5 uM)	Cancer Cell Int. 2005 Jul 11;5:21.	27	L
FPDB00689	3102|||3103|||3104|||3105|||3106|||3107|||3254|||3255|||3256|||3257|||3258|||3259|||DRAMP31802	PDEDAINNALNKVCSTGRRQRSICKQLLKK	100% cell viability at 5 uM||40% cell viability at 50 uM||<40% cell viability at 50 uM||<100% cell viability at 5 uM||<20% cell viability at 50 uM||100% cell viability at 5 uM<40% cell viability at 50 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12087-92.	30	L
FPDB00690	3108|||3109|||3110|||3111|||3112|||3113|||3260|||3261|||3262|||3265|||DRAMP31801	PDEDAINDALNKVCSTGRRQRSICKQLLKK	>100% cell viability at 5 uM||60% cell viability at 50 uM||100% cell viability at 5 uM||<60% cell viability at 50 uM||<100% cell viability at 5 uM||<40% cell viability at 50 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12087-92.	30	L
FPDB00691	3114|||3115|||3116|||3117|||3118|||3122|||MAP-04-03|||DRAMP18564	KWLRRVWRWWR	Cell viability >80% at 25 uM||Cell viability ~50% at 50 uM||Cell viability <40% at 75 uM||Cell viability >20% at 100 uM||Cell viability ~100% at 25 uM||activity value is IC50 = 61.5 uM||Anti-Staphylococcus aureus, activity value is MIC = 2.5 uM||Anti-Escherichia coli, activity value is MIC = 15 uM||Anti-Pseudomonas aeroginosa, activity value is MIC = 20 uM||Anti-Staphylococcus aureus, activity value is MIC = 90||Anti-##Gram-negative bacterium: Escherichia coli, activity value is MIC = 90||Anti-Pseudomonas aeroginosa, activity value is MIC = 90	Synthetic construct	N/A	Human red blood cells (100% hemolysis at 100 uM)|||[Ref.22578463]100% hemolysis at 100 uM against human red blood cells	22578463|||Bioorg Med Chem Lett. 2012 Jun 15;22(12):4185-8.||Ref.22578463	11	L
FPDB00692	3119|||3120|||3121|||MAP-04-04|||DRAMP18565	KRLRRVWRRWR	Cell viability >80% at 50 uM||Cell viability >80% at 75 uM||Cell viability >80% at 100 uM||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-Escherichia coli, activity value is MIC = 30 uM||Anti-Pseudomonas aeroginosa, activity value is MIC = 20 uM||Anti-Staphylococcus aureus, activity value is MIC = 90||Anti-##Gram-negative bacterium: Escherichia coli, activity value is MIC = 90||Anti-Pseudomonas aeroginosa, activity value is MIC = 90	Synthetic construct	N/A	Human red blood cells (3% hemolysis at 100 uM)|||[Ref.22578463]3% hemolysis at 100 uM against human red blood cells	22578463|||Bioorg Med Chem Lett. 2012 Jun 15;22(12):4185-8.||Ref.22578463	11	L
FPDB00693	3123|||3124|||Antimicrobial peptide TsAP-1	FLSLIPSLVGGSISAFK	activity value is IC50 = 55.9 uM||activity value is IC50 = 52.5 uM||Antibacterial||Antifungal||Anticancer ; S.aureus||E.coli||C.albicans	N/A	N/A	N/A	23770440	17	L
FPDB00694	3135|||3136|||3137|||3138|||3139|||DRAMP21245	FLGMIPKLIKKLIKAFK	activity value is IC50 = 0.83 uM||activity value is IC50 = 1.6 uM||activity value is IC50 = 1.8 uM||activity value is IC50 = 2 uM||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||activity value is MBC = 20 uM||Anti-Escherichia coli, activity value is MIC = 5 uM||activity value is MBC = 40 uM||Anti-Candida albicans, activity value is MIC = 2.5 uM||activity value is MBC = 10 uM||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 5 uM||Anti-##Fungi : Candida albicans, activity value is MIC = 2.5 uM	Synthetic construct	Alpha helix	"- TsAP-1: At 160 µM, the hemolysis rate is only 6.48%, indicating low hemolytic activity.

- TsAP-2: No hemolysis at ≤15 µM; 86% hemolysis at 40 µM; complete hemolysis (100%) at ≥80 µM.

- TsAP-S1: 28% hemolysis at 5 µM; complete hemolysis (100%) at ≥20 µM.

- TsAP-S2: 28% hemolysis at 5 µM; complete hemolysis (100%) at ≥20 µM.|||[Ref.23770440] 30% hemolysis at 5 uM , 85% hemolysis at 10 uM , 100% hemolysis at 20 uM against horse red blood cells"	Biochimie. 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003.||Ref.23770440|||Biochimie. 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003.||Ref.23770440	17	L
FPDB00695	3140|||3141|||3142|||DRAMP32913|||DRAMP32914|||DRAMP32915|||DRAMP32916	CHHNLTHAC	4.5 ± 0.1.4% cell growth inhibition at 160 uM in 48 h||19 ± 2.82% cell growth inhibition at 160 uM in 72 h||4 ± 1.4% cell growth inhibition at 160 uM in 72 h||Antimicrobial||Anticancer	Synthetic|||Synthetic (Derived from PTPRJ pep-19)	N/A	N/A	ACS Chem Biol. 2013 Jul 19;8(7):1497-506.	9	L
FPDB00696	3143|||3144|||3145|||DRAMP32917	CAHNLTHAC	16.5 ± 2.12% cell growth inhibition at 160 uM in 24 h||30 ± 2.82% cell growth inhibition at 160 uM in 48 h||32.0  ± 4.2% cell growth inhibition at 160 uM in 72 h||Antimicrobial||Anticancer	Synthetic (Derived from PTPRJ pep-19)	N/A	N/A	ACS Chem Biol. 2013 Jul 19;8(7):1497-506.	9	L
FPDB00697	3146|||3147|||3148|||DRAMP32918	CHANLTHAC	28  ± 5.5% cell growth inhibition at 160 uM in 24 h||46  ± 4.2% cell growth inhibition at 160 uM in 48 h||51  ± 1.4% cell growth inhibition at 160 uM in 72 h||Antimicrobial||Anticancer	Synthetic (Derived from PTPRJ pep-19)	N/A	N/A	ACS Chem Biol. 2013 Jul 19;8(7):1497-506.	9	L
FPDB00698	3149|||3150|||3151|||DRAMP32919	CHHALTHAC	48.0  ± 2.82% cell growth inhibition at 160 uM in 24 h||62.5  ± 4.9% cell growth inhibition at 160 uM in 48 h||66.5  ± 2.12% cell growth inhibition at 160 uM in 72 h||Antimicrobial||Anticancer	Synthetic (Derived from PTPRJ pep-19)	N/A	N/A	ACS Chem Biol. 2013 Jul 19;8(7):1497-506.	9	L
FPDB00699	3152|||3153|||DRAMP32920	CHHNATHAC	2  ± 1.5% cell growth inhibition at 160 uM in 48 h||19  ± 4.2% cell growth inhibition at 160 uM in 72 h||Antimicrobial||Anticancer	Synthetic (Derived from PTPRJ pep-19)	N/A	N/A	ACS Chem Biol. 2013 Jul 19;8(7):1497-506.	9	L
FPDB00700	3154|||DRAMP32921	CHHNLAHAC	19  ± 4.2% cell growth inhibition at 160 uM in 72 h||Antimicrobial||Anticancer	Synthetic (Derived from PTPRJ pep-19)	N/A	N/A	ACS Chem Biol. 2013 Jul 19;8(7):1497-506.	9	L
FPDB00701	3155|||3156|||DRAMP32922	CHHNLTAAC	4.5  ± 2.13% cell growth inhibition at 160 uM in 48 h||20 ± 1.4% cell growth inhibition at 160 uM in 72 h||Antimicrobial||Anticancer	Synthetic (Derived from PTPRJ pep-19)	N/A	N/A	ACS Chem Biol. 2013 Jul 19;8(7):1497-506.	9	L
FPDB00702	3198|||3200|||3201|||3202|||3203|||3204|||3205|||3208|||3210|||3211|||3212|||3213|||3214|||3215|||DRAMP34940	MTLTG	Antimicrobial||Anticancer	Immunomodulatory bursal-derived Pentapeptide-II	N/A	N/A	J Biol Chem. 2012 Feb 3;287(6):3798-807.	5	L
FPDB00703	3222|||3223|||3224|||3225|||DRAMP31792	KVKVKVKVPPTKVKVKVK	activity value is IC50 > 100 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	J Am Chem Soc. 2012 Apr 11;134(14):6210-7.	18	L
FPDB00704	3266|||CAMPSQ20048|||CAMPSQ20049|||CAMPSQ20050|||CAMPSQ20051|||CAMPSQ20052|||CAMPSQ20053|||CAMPSQ20054|||DRAMP31823|||DRAMP31824	FLGALFHALSKLL	activity value is IC50 = 28 uM||Anti-Human lung carcinoma A549, activity value is IC50 = 52||Anti-Human lung carcinoma A549, activity value is IC50 = 27||Anti-Escherichia coli ATCC 25404, activity value is MIC > 64 uM||Anti-Escherichia coli O157, activity value is MIC > 64 uM||Anti-Salmonella typhimurium, activity value is MIC > 64 uM||Anti-Listeria monocytogenes, activity value is MIC = 8 uM||Anti-Micrococcus luteus ATCC 10420, activity value is MIC = 2 uM||Anti-Staphylococcus epidermidis ATCC 9709, activity value is MIC = 4 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 4 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC = 4 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 1 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2 uM||Anti-Human pancreatic carcinoma Panc-1, activity value is IC50 = 57 uM||Anti-Human pancreatic carcinoma Panc-1, activity value is IC50 = 58 uM||Anti-Human pancreatic carcinoma Panc-1, activity value is IC50 = 59 uM||Anti-Human pancreatic carcinoma Panc-1, activity value is IC50 = 60 uM||Anti-Human pancreatic carcinoma Panc-1, activity value is IC50 = 61 uM||Anti-Human pancreatic carcinoma Panc-1, activity value is IC50 = 62 uM||Anti-Human pancreatic carcinoma Panc-1, activity value is IC50 = 63 uM||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Normal breast cells MCF-10a (IC50 at 32 uM, Human erythrocytes (0.5% Hemolysis at 7.5 uM|||Normal breast cells MCF-10a (IC50 at 32 uM, Human erythrocytes (0.5% Hemolysis at 7.6 uM|||Normal breast cells MCF-10a (IC50 at 32 uM, Human erythrocytes (0.5% Hemolysis at 7.7 uM|||Normal breast cells MCF-10a (IC50 at 32 uM, Human erythrocytes (0.5% Hemolysis at 7.8 uM|||Normal breast cells MCF-10a (IC50 at 32 uM, Human erythrocytes (0.5% Hemolysis at 7.9 uM|||Normal breast cells MCF-10a (IC50 at 32 uM, Human erythrocytes (0.5% Hemolysis at 7.1 uM|||Normal breast cells MCF-10a (IC50 at 32 uM, Human erythrocytes (0.5% Hemolysis at 7.11 uM|||Human erythrocytes: 6.8% Hemolysis=30 uM|||Human erythrocytes: 8.8% Hemolysis=30 uM	19464332, 22526264|||19464332, 22526265|||19464332, 22526266|||19464332, 22526267|||19464332, 22526268|||19464332, 22526269|||19464332, 22526270|||Biomacromolecules. 2012 Oct 8;13(10):3327-33.	13	L
FPDB00705	3267	FLGALFKALSHLL	activity value is IC50 = 32 uM	N/A	N/A	N/A	N/A	13	L
FPDB00706	3271|||3272|||AP05137|||PST13-RK|||DRAMP31677	KKKFPWWWPFKKK	activity value is IC50 = 90 ug/ml||activity value is IC50 = 80 ug/ml||Anti-Gram+ & Gram-||Anti-Escherichia coli, activity value is MIC = 2 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 4 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 2 ug/ml||Antimicrobial||Anticancer	sequence extension, amino acid SUBSTITUTION, amino acid deletion, porcine cathelicidin, animal-derived, natural derivatives|||Synthetic construct|||Derivative of tritrpticin	N/A	Human erythroctes (<5% hemolysis at 100 uM)	Int J Antimicrob Agents. 2006 Apr;27(4):325-30. doi: 10.1016/j.ijantimicag.2005.11.014. PubMed|||16563706|||Biotechnol Lett. 2009 Feb;31(2):233-7.	13	L
FPDB00707	3282|||3283|||3284|||3285|||3286|||3287|||3314|||3315|||3316|||3341|||CAMPSQ9484|||DRAMP31683	FKCRRWQWRMKK	activity value is IC50 = 38 uM||activity value is IC50 = 55 uM||activity value is IC50 = 57 uM||activity value is IC50 = 16 uM||activity value is IC50 = 13 uM||activity value is IC50 = 10 uM||activity value is IC50 > 160 uM||activity value is IC50 = 141||Inhibition at 100000 ug/l||Antibacterial||Antimicrobial||Anticancer	Synthetic construct|||Bovine lactoferrin (Lf-B)	N/A	N/A	28613262|||BMC Cancer. 2009 Jun 15;9:183.	12	L
FPDB00708	3288|||3289|||Undefined|||DRAMP31684	KAAKKAAKAAKKAAKAAKKAA	activity value is IC50 = 30||activity value is IC50 = 55||Antibacterial||Antimicrobial||Anticancer	Synthetic construct|||Bovine lactoferrin (Lf-B)	N/A	Human erythrocytes (<10% Hemolysis at >1630 uM	8759631|||BMC Cancer. 2009 Jun 15;9:183.	21	L
FPDB00709	3321|||3322|||3323|||3324|||NK-2 C7A|||DRAMP31848	KILRGVAKKIMRTFLRRISKDILTGKK	activity value is IC50 = 10.6||activity value is IC50 = 13||activity value is IC50 = 12.1||activity value is IC50 = 37||Anti-Staphylococcus aureus SA113, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus SA113, activity value is MIC > 256 ug/ml||Anti-Staphylococcus aureus SA113, activity value is MBC = 32 ug/ml||Anti-Staphylococcus aureus SA113, activity value is MBC > 256 ug/ml||Anti-Staphylococcus aureus Del-mprF, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus Del-mprF, activity value is MBC = 32 ug/ml||Anti-Staphylococcus aureus Del-mprF, activity value is MBC = 16 ug/ml||Anti-Staphylococcus aureus Del-mprFpRBsyn, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus Del-mprFpRBsyn, activity value is MBC = 16 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus, activity value is MBC = 32 ug/ml||Anti-Staphylococcus aureus, activity value is MBC = 64 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Whole blood cells: experiments revealed absent or minimal hemolysis	21474443|||Oncotarget. 2014 Jun 30;5(12):4467-79.	27	L
FPDB00710	3325|||3326|||3327|||3328|||3794|||3800|||3806|||3812|||DRAMP31850	KILRGVAKKIMRTFLRRISKKILTGKK	activity value is IC50 = 8.4||activity value is IC50 = 12.3||activity value is IC50 = 8.3||Antimicrobial||Anticancer	Synthetic	N/A	Whole blood cells: experiments revealed absent or minimal hemolysis	Oncotarget. 2014 Jun 30;5(12):4467-79.	27	L
FPDB00711	3329|||3330|||3331|||3332|||3795|||3801|||3807|||3813|||DRAMP31849	KILRGVAKKIMRTFLRRILTGKK	activity value is IC50 = 7.5||activity value is IC50 = 13.8||activity value is IC50 = 9.3||activity value is IC50 = 13.1||Antimicrobial||Anticancer	Synthetic	N/A	Whole blood cells: experiments revealed absent or minimal hemolysis	Oncotarget. 2014 Jun 30;5(12):4467-79.	23	L
FPDB00712	3333|||3334|||3335|||3336|||3790|||3796|||3802|||3808|||3814|||NK11|||DRAMP33374	KISKRILTGKK	IC50 >>100 uM||IC-50 >> 100 uM||IC-50>> 100 uM||IC50 >> 100 uM||Anti-Staphylococcus aureus SA113, activity value is MIC > 256 ug/ml||Anti-Staphylococcus aureus SA113, activity value is MBC > 256 ug/ml||Anti-Staphylococcus aureus Del-mprF, activity value is MIC = 256 ug/ml||Anti-Staphylococcus aureus Del-mprF, activity value is MIC > 256 ug/ml||Anti-Staphylococcus aureus Del-mprF, activity value is MBC > 256 ug/ml||Anti-Staphylococcus aureus Del-mprFpRBsyn, activity value is MIC = 256 ug/ml||Anti-Staphylococcus aureus Del-mprFpRBsyn, activity value is MBC > 256 ug/ml||Anti-Staphylococcus aureus, activity value is MIC > 256 ug/ml||Anti-Staphylococcus aureus, activity value is MBC > 256 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC > 256 ug/ml||Anti-Acinetobacter baumannii ATCC 19606, activity value is MIC > 256 ug/ml||Anti-Bordetella bronchiseptica CUN 11844-99, activity value is MIC > 256 ug/ml||Anti-Brucella abortus 9.49, activity value is MIC > 256 ug/ml||Anti-Brucella abortus 9.49, activity value is MBC > 256 ug/ml||Anti-Pseudomonas aeruginosa CUN 4158-02, activity value is MIC > 256 ug/ml||Anti-Yersinia pestis KIM pYV, activity value is MIC > 256 ug/ml||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC > 256 ug/ml||Anti-Escherichia coli ATCC 23716, activity value is MIC > 256 ug/ml||Anti-Escherichia coli ATCC 23716, activity value is MIC = 200 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC > 256 ug/ml||Anti-Acinetobacter baumannii ATCC 19606, activity value is MBC > 256 ug/ml||Anti-Bordetella bronchiseptica CUN 11844-99, activity value is MBC > 256 ug/ml||Anti-Pseudomonas aeruginosa CUN 4158-02, activity value is MBC > 256 ug/ml||Anti-Yersinia pestis KIM pYV, activity value is MBC > 256 ug/ml||Anti-Staphylococcus aureus ATCC 43300, activity value is MBC > 256 ug/ml||Anti-Escherichia coli ATCC 23716, activity value is MBC > 256 ug/ml||Anti-Escherichia coli ATCC 23716, activity value is MBC > 200 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Human erythrocytes (5% Hemolysis at 100 ug/ml	21474443, 17389605|||J Biol Chem. 2007 May 18;282(20):14719-28.	11	L
FPDB00713	3342|||DRAMP31829	YPFPG	Inhibition at 9000000-11000000 ug/l||Antimicrobial||Anticancer	Bovine milk	N/A	N/A	J Amino Acids. 2013;2013:939804.	5	L
FPDB00714	3343|||DRAMP31828	RYLGYL	Inhibition at 12000000-15000000 ug/l||Antimicrobial||Anticancer	Bovine milk	N/A	N/A	J Amino Acids. 2013;2013:939804.	6	L
FPDB00715	3344|||DRAMP31827	PPPEE	Inhibition at 24000000-28000000 ug/l||Antimicrobial||Anticancer	Bovine milk	N/A	N/A	J Amino Acids. 2013;2013:939804.	5	L
FPDB00716	3356|||3357|||3358|||3359|||3360|||3361	KWKKLLKKPPPLLKKLLKKL	35% survival rate at 10 uM||0% survival rate at 100 uM||~60% survival rate at 10 uM||~20% survival rate at 10 uM	N/A	N/A	N/A	N/A	20	L
FPDB00717	3362|||3363|||3364|||3365|||3366|||3367|||3380|||3381|||3382|||3383|||3384|||3385|||3398|||3399|||3400|||3401|||3402|||3403|||3416|||3417|||3418|||3419|||3420|||3421|||3434|||3435|||3436|||3437|||3438|||3439|||3452|||3453|||3454|||3455|||3456|||3457	NHFTLKCPKTALTEPPTLAY	<5% cytotoxicity at 1 uM||<20% cytotoxicity at 10 uM||~15% cytotoxicity at 1 uM||>20% cytotoxicity at 10 uM||<5% cytotoxicity at 10 uM||10% cytotoxicity at 1 uM||<10% cytotoxicity at 10 uM||~25% cytotoxicity at 1 uM||<25% cytotoxicity at 10 uM||~45% cytotoxicity at 1 uM||<45% cytotoxicity at 10 uM||20% cytotoxicity at 1 uM||10% cytotoxicity at 10 uM||<3% cytotoxicity at 10 uM||<20% cytotoxicity at 1 uM||15% cytotoxicity at 10 uM||5% cytotoxicity at 10 uM||20% cytotoxicity at 10 uM||~5% cytotoxicity at 10 uM||~10% cytotoxicity at 1 uM||~10% cytotoxicity at 10 uM||~15% cytotoxicity at 10 uM	N/A	N/A	N/A	N/A	20	L
FPDB00718	3368|||3369|||3370|||3371|||3372|||3373|||3386|||3387|||3388|||3389|||3390|||3391|||3404|||3405|||3409|||3422|||3423|||3424|||3425|||3426|||3427|||3440|||3441|||3442|||3443|||3444|||3445|||3458|||3459|||3460|||3461|||3462|||3463	TAGIKLTVPIEKFPVTTQTFWG	<5% cytotoxicity at 1 uM||~10% cytotoxicity at 10 uM||10% cytotoxicity at 1 uM||>10% cytotoxicity at 10 uM||>10% cytotoxicity at 1 uM||<5% cytotoxicity at 10 uM||~25% cytotoxicity at 1 uM||~25% cytotoxicity at 10 uM||>25% cytotoxicity at 10 uM||~45% cytotoxicity at 1 uM||<45% cytotoxicity at 10 uM||<15% cytotoxicity at 1 uM||15% cytotoxicity at 10 uM||5% cytotoxicity at 1 uM||<3% cytotoxicity at 1 uM||>20% cytotoxicity at 10 uM||~20% cytotoxicity at 1 uM||~40% cytotoxicity at 10 uM||~5% cytotoxicity at 1 uM||~15% cytotoxicity at 10 uM||~15% cytotoxicity at 1 uM||<3% cytotoxicity at 10 uM	N/A	N/A	N/A	N/A	22	L
FPDB00719	3374|||3375|||3376|||3377|||3378|||3379|||3392|||3393|||3394|||3395|||3396|||3397|||3410|||3411|||3412|||3413|||3414|||3415|||3428|||3429|||3430|||3431|||3432|||3433|||3446|||3447|||3448|||3449|||3450|||3451|||3464|||3465|||3466|||3467|||3468|||3469	GQVWEATATVNAIRGSVTPAVSQFNARTAD	<5% cytotoxicity at 1 uM||<5% cytotoxicity at 10 uM||>20% cytotoxicity at 1 uM||~35% cytotoxicity at 10 uM||~20% cytotoxicity at 10 uM||~30% cytotoxicity at 1 uM||<30% cytotoxicity at 10 uM||<30% cytotoxicity at 1 uM||~50% cytotoxicity at 10 uM||>40% cytotoxicity at 1 uM||50% cytotoxicity at 10 uM||<20% cytotoxicity at 1 uM||>20% cytotoxicity at 10 uM||>30% cytotoxicity at 1 uM||~40% cytotoxicity at 10 uM||>40% cytotoxicity at 10 uM||~20% cytotoxicity at 1 uM||~45% cytotoxicity at 10 uM||~55% cytotoxicity at 10 uM||40% cytotoxicity at 1 uM||20% cytotoxicity at 10 uM	N/A	N/A	N/A	N/A	30	L
FPDB00720	3496|||3518|||3521|||3543|||3546|||3568|||LL-III/2|||DRAMP18605	VNWKKILAKIIKVVK	activity value is IC50 = 3||activity value is IC50 = 8 uM||activity value is IC50 = 12||Anti-Bacillus subtilis, activity value is MIC = 0.6 uM||Anti-Staphylococcus aureus, activity value is MIC = 2.2 uM||Anti-Escherichia coli, activity value is MIC = 1.4 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 27.1 uM||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 1.4 uM	Synthetic construct	N/A	Rat red blood cells (LC50 = 55.1 uM)|||[Ref.19591185]LC50=55.1 uM against rat red blood cells	19591185|||Chembiochem. 2009 Aug 17;10(12):2089-2111.||Ref.19591185	15	L
FPDB00721	3497|||3522|||3547|||LL-III/1|||DRAMP18604	NVWKKILGKIIKVVK	activity value is IC50 = 11 uM||activity value is IC50 = 7||Anti-Bacillus subtilis, activity value is MIC = 0.7 uM||Anti-Staphylococcus aureus, activity value is MIC = 9 uM||Anti-Escherichia coli, activity value is MIC = 1.4 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 23.1 uM||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 1.4 uM	Synthetic construct	N/A	Rat red blood cells (LC50 = >200 uM)|||[Ref.19591185]LC50>200 uM against rat red blood cells	19591185|||Chembiochem. 2009 Aug 17;10(12):2089-2110.||Ref.19591185	15	L
FPDB00722	3498|||3523|||3548|||LL-III/3|||DRAMP18606	VNWKKILKKIIKVVK	activity value is IC50 > 40 uM||Anti-Bacillus subtilis, activity value is MIC = 0.7 uM||Anti-Staphylococcus aureus, activity value is MIC = 9.6 uM||Anti-Escherichia coli, activity value is MIC = 0.7 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 26.1 uM||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 0.7 uM	Synthetic construct	N/A	Rat red blood cells (LC50 = 72.2 uM)|||[Ref.19591185]LC50=72.2 uM against rat red blood cells	19591185|||Chembiochem. 2009 Aug 17;10(12):2089-2112.||Ref.19591185	15	L
FPDB00723	3499|||3524|||3549|||DRAMP31783	VNWKKILGKIKKVVK	activity value is IC50 = 7||activity value is IC50 > 40 uM||activity value is IC50 = 18 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	15	L
FPDB00724	3500|||3525|||3550|||LL-III/4|||DRAMP18607	VNWKKILPKIIKVVK	activity value is IC50 > 40 uM||activity value is IC50 = 6||Anti-Bacillus subtilis, activity value is MIC = 0.8 uM||Anti-Staphylococcus aureus, activity value is MIC = 32.5 uM||Anti-Escherichia coli, activity value is MIC = 1.2 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 100 uM||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 1.2 uM	Synthetic construct	N/A	Rat red blood cells (LC50 = >200 uM)|||[Ref.19591185]LC50>200 uM against rat red blood cells	19591185|||Chembiochem. 2009 Aug 17;10(12):2089-2113.||Ref.19591185	15	L
FPDB00725	3503|||3528|||3553|||DRAMP31773	KNWKKILGKIIKVVK	activity value is IC50 = 9||activity value is IC50 = 9 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	15	L
FPDB00726	3504|||3529|||3554|||DRAMP31780	VNWKKIILGKIIKVVK	activity value is IC50 = 8||activity value is IC50 = 48 uM||activity value is IC50 = 4||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	16	L
FPDB00727	3506|||3531|||3556|||DRAMP31777	VNFKKLLGKLLKVVK	activity value is IC50 = 7||activity value is IC50 = 42 uM||activity value is IC50 = 9||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	15	L
FPDB00728	3508|||3533|||3558|||DRAMP31788	VNWRRILGRIIRVVR	activity value is IC50 = 9 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	15	L
FPDB00729	3509|||3534|||3559|||DRAMP31774	KNWKKILKKIIKVVK	activity value is IC50 = 3 uM||activity value is IC50 = 7||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	15	L
FPDB00730	3512|||3537|||3562|||DRAMP31784	VNWKKLLGKLLKVVK	activity value is IC50 = 4 uM||activity value is IC50 = 15 uM||activity value is IC50 = 6 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	15	L
FPDB00731	3515|||3540|||3565|||DRAMP31789	VYWKKILGKIIKVVK	activity value is IC50 = 5||activity value is IC50 = 30 uM||activity value is IC50 = 6 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	15	L
FPDB00732	3516|||3541|||3566|||DRAMP31786	VNWKKVLGKVVKVVK	activity value is IC50 = 13||activity value is IC50 > 100 uM||activity value is IC50 = 18 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	15	L
FPDB00733	3517|||3542|||3567|||DRAMP31776	NKWKKILGKIIKVVK	activity value is IC50 = 5||activity value is IC50 = 37 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	15	L
FPDB00734	3589|||3605|||3621|||CAMPSQ20593|||Macropin 1|||DRAMP31750	AFGMALKLLKKVL	activity value is IC50 = 16||activity value is IC50 = 16 uM||activity value is IC50 = 17 uM||Anti-Human cervical carcinoma HeLa S3, activity value is IC50 = 16||Anti-Human colon adenocarcinoma SW480, activity value is IC50 = 16 uM||Anti-Human lymphoblastic leukemia CCRF-CEM, activity value is IC50 = 17 uM||Anti-Bacillus subtilis 168, activity value is MIC = 1.3 uM||Anti-Staphylococcus aureus, activity value is MIC = 4.7 uM||Anti-Escherichia coli B, activity value is MIC = 4.7 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 38.3 uM||Anti-Candida albicans F7-39/IDE99, activity value is MIC = 10 uM||Anti-Bacillus subtilis 168, activity value is MIC = 2.1 uM||Anti-Staphylococcus aureus, activity value is MIC = 5.7 uM||Anti-Escherichia coli B, activity value is MIC = 4.4 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 37 uM||Anti-Candida albicans F7-39/IDE99, activity value is MIC = 8 uM||Antibacterial||Antifungal||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Human umbilical vein endothelial cells HUVEC (IC50 at 30+-4 uM, Human erythrocytes (50% Hemolysis at 120 uM|||Human erythrocytes: IC50>200 uM	24616110|||Peptides. 2012 Jan;33(1):18-26.	13	L
FPDB00735	3590|||3606|||3622|||CAMPSQ20594|||Macropin 1|||DRAMP31775	LFGMALKLLKKVL	activity value is IC50 = 9||activity value is IC50 = 11||activity value is IC50 = 22 uM||Anti-Human cervical carcinoma HeLa S3, activity value is IC50 = 9||Anti-Human colon adenocarcinoma SW480, activity value is IC50 = 11||Anti-Human lymphoblastic leukemia CCRF-CEM, activity value is IC50 = 22 uM||Anti-Bacillus subtilis 168, activity value is MIC = 1.5 uM||Anti-Staphylococcus aureus, activity value is MIC = 2.3 uM||Anti-Escherichia coli B, activity value is MIC = 3.8 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 50 uM||Anti-Candida albicans F7-39/IDE99, activity value is MIC = 10 uM||Antibacterial||Antifungal||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Human umbilical vein endothelial cells HUVEC (IC50 at 27+-5 uM|||Human erythrocytes: IC50=53 uM	24616110|||Peptides. 2012 Jan;33(1):18-26.	13	L
FPDB00736	3593|||3594|||3610|||3625|||3626|||CAMPSQ20595|||Macropin 1|||DRAMP31762	GFKMALKLLKKVL	activity value is IC50 = 8||activity value is IC50 = 15||activity value is IC50 = 14||activity value is IC50 = 16 uM||Anti-Human cervical carcinoma HeLa S3, activity value is IC50 = 8||Anti-Human colon adenocarcinoma SW480, activity value is IC50 = 13||Anti-Human lymphoblastic leukemia CCRF-CEM, activity value is IC50 = 14||Anti-Bacillus subtilis 168, activity value is MIC = 1.3 uM||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-Escherichia coli B, activity value is MIC = 2.3 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 11.3 uM||Anti-Candida albicans F7-39/IDE99, activity value is MIC = 4.3 uM||Anti-Human cervical carcinoma HeLa S3, activity value is IC50 = 15||Anti-Human lymphoblastic leukemia CCRF-CEM, activity value is IC50 = 16 uM||Anti-Bacillus subtilis 168, activity value is MIC = 0.8 uM||Anti-Staphylococcus aureus, activity value is MIC = 6.7 uM||Anti-Escherichia coli B, activity value is MIC = 1.8 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 12.8 uM||Anti-Candida albicans F7-39/IDE99, activity value is MIC = 5.5 uM||Anti-Bacillus subtilis 168, activity value is MIC = 1.7 uM||Anti-Staphylococcus aureus, activity value is MIC = 12.5 uM||Anti-Escherichia coli B, activity value is MIC = 4 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 20 uM||Anti-Candida albicans F7-39/IDE99, activity value is MIC = 8.7 uM||Antibacterial||Antifungal||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Human umbilical vein endothelial cells HUVEC (IC50 at 17+-2 uM, Human umbilical vein endothelial cells HUVEC (IC50 at 23 uM, Human erythrocytes (50% Hemolysis at 391 uM|||Human erythrocytes: IC50=199 uM	24616110|||Peptides. 2012 Jan;33(1):18-26.	13	L
FPDB00737	3598|||3614|||3630|||DRAMP31760	GFGMALRLLRRVL	activity value is IC50 = 9||activity value is IC50 = 17||activity value is IC50 = 22||Antimicrobial||Anticancer	Synthetic	N/A	Human erythrocytes: IC50=72 uM	Peptides. 2012 Jan;33(1):18-26.	13	L
FPDB00738	3636|||3664|||3692	GMWSKILGHLIK	activity value is IC50 = 15||activity value is IC50 > 100 uM	N/A	N/A	N/A	N/A	12	L
FPDB00739	3637|||3665|||3693|||DRAMP32901	GMWSKILGHLKR	activity value is IC50 > 100 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00740	3638|||3666|||3694|||DRAMP32902	GMWSKILGKLIR	activity value is IC50 = 9||activity value is IC50 > 50 uM||activity value is IC50 = 30||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00741	3639|||3667|||3695|||DRAMP32903	GMWSKILKHLIR	activity value is IC50 = 4||activity value is IC50 = 18||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00742	3641|||3669|||DRAMP32894	GKWSKILGHLIR	activity value is IC50 = 43||activity value is IC50 > 100 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00743	3642|||3670|||3698|||DRAMP31771	KMWSKILGHLIR	activity value is IC50 = 35||activity value is IC50 > 100 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00744	3643|||3699|||DRAMP32897	GMWKKILGKLIR	activity value is IC50 = 13||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00745	3644|||3672|||3700|||DRAMP32895	GKWSKILGKLIR	activity value is IC50 = 22||activity value is IC50 > 40 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00746	3645|||3673|||3701|||DRAMP31764	GKWKKILGHLIR	activity value is IC50 > 100 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00747	3646|||3674|||3702|||CAMPSQ11740|||DRAMP31765	GKWKKILGKLIR	activity value is IC50 = 30||activity value is IC50 > 100 uM||Antibacterial||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Rat erythrocytes: IC50>200 uM	30447380|||Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00748	3648|||3676|||3704|||DRAMP31769	GMWSKLLGHLLR	activity value is IC50 = 14||activity value is IC50 > 40 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50=62 uM	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00749	3651|||3679|||3707|||DRAMP32891	GKWMSLLKKILK	activity value is IC50 > 40 uM||activity value is IC50 = 38||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00750	3652|||3680|||3708|||DRAMP31768	GKWMKLLKHILK	activity value is IC50 = 6||activity value is IC50 = 35||activity value is IC50 > 40 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50=87.4 uM	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00751	3653|||3681|||DRAMP31766	GKWKSLLKHILK	activity value is IC50 = 14||activity value is IC50 > 100 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00752	3655|||3683|||3711|||DRAMP32889	GKWMSLLKHIWK	activity value is IC50 = 14||activity value is IC50 > 40 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00753	3656|||3712|||DRAMP32890	GKWMSLLKHWLK	activity value is IC50 = 16||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00754	3658|||3686|||3714|||DRAMP31763	GKFMSLLKHILK	activity value is IC50 = 34 uM||activity value is IC50 > 40 uM||Antimicrobial||Anticancer	Synthetic	N/A	Rat erythrocytes: IC50>200 uM	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00755	3659|||3687|||3715|||DRAMP32886	GKWMSFLKHILK	activity value is IC50 = 23||activity value is IC50 > 40 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00756	3660|||3688|||3716|||DRAMP32893	GKWMTLLKHILK	activity value is IC50 = 13||activity value is IC50 > 60 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00757	3661|||3689|||3717|||CAMPSQ19899|||Halictine-2/11, HAL-2/11|||DRAMP31767	GKWLSLLKHILK	activity value is IC50 = 14||activity value is IC50 = 40 uM||Antibacterial||Antifungal||Antimicrobial||Anticancer	Synthetic construct|||Synthetic	N/A	Human umbilical vein endothelial cells HUVEC (IC50 at 21.6+-2.4 uM|||Rat erythrocytes: IC50=65 uM	30240951|||Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00758	3668|||3696|||DRAMP32896	GMWKKILGHLIR	activity value is IC50 = 44||activity value is IC50 > 40 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00759	3685|||3713|||DRAMP32892	GKWMSLWKHILK	activity value is IC50 > 40 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Peptides. 2012 Jan;33(1):18-26.	12	L
FPDB00760	3718|||DRAMP35154	YGRKKRRQRRRREADFFWSLCTADMS	Antimicrobial||Anticancer	N/A	N/A	N/A	Cell Death Dis. 2013 Oct 31;4(10):e894.	26	L
FPDB00761	3726|||DRAMP31796	PLLQATLGGGS	activity value is IC50 = 1 uM||Antimicrobial||Anticancer	No information found in the references	N/A	N/A	J Cancer Res Clin Oncol. 2012 Aug;138(8):1321-8.	11	L
FPDB00762	3793|||3799|||3811|||DRAMP35125	KILRGVAKKILRTFLRRISKDILTGKK	activity value is IC50 = 10.6||activity value is IC50 = 13||activity value is IC50 = 3.7||Antimicrobial||Anticancer	N/A	N/A	N/A	J Pept Sci. 2013 Oct;19(10):619-28.	27	L
FPDB00763	3816|||3817|||3821|||3824	MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQL	Cell viability(% of control)=0.5 at concentration 7 ug/ml||Cell viability(% of control)= 0.5 at concentration 8 ug/ml||Apoptotic rate(%)= >30% at concentration of 8 ug/ml||Apoptotic rate(%)= >50% at concentration of 8 ug/ml	N/A	N/A	N/A	N/A	180	L
FPDB00764	3818|||3819|||3823	MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRGDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL	Cell viability(% of control)=0.5 at concentration 4 ug/ml||Cell viability(% of control)= 0.5 at concentration 8 ug/ml||Apoptotic rate(%)= >70% at concentration of 8 ug/ml	N/A	N/A	N/A	N/A	207	L
FPDB00765	3826|||3827|||3828	MDSNKDERAYAQWVIIILHNVGSSPFKIANLGLSWGKLYADGNKDKEVYPSDYNGKTVGPDEKIQINSCGRENASSGTEGSFDIVDPNDGNKTIRHFYWECPWGSKRNTWTPSGSNTKWMVEWSGQNLDSGALGTITVDVLRKGN	At 2.5 uM concentration||decrease in cell vibility= 35%||decrease in cell vibility= 70%	N/A	N/A	N/A	N/A	145	L
FPDB00766	3834|||3835|||3836	IVRRADRAAVP	60% inhibition at 2.5 ug/ml||60% inhibition at 5 ug/ml||60% inhibition at 10 ug/ml	N/A	N/A	N/A	N/A	11	L
FPDB00767	3837|||3838|||3839|||3841|||3842|||DRAMP31693|||DRAMP31694|||DRAMP31695|||DRAMP31696	ACDCRGDCFCGGGGIVRRADRAAVP	50% inhibition at 2.5 ug/ml||40% inhibition at 5 ug/ml||75% inhibition at 10 ug/ml||42% inhibition at 5 ug/ml||52% inhibition at 10 ug/ml||Antimicrobial||Anticancer	Endostatin derived Synthetic	N/A	N/A	Bioconjug Chem. 2010 Jul 21;21(7):1142-7.	25	L
FPDB00768	4048|||4049|||4050|||4051|||4052|||4053|||4054|||4055|||4056|||Citropin-1.3	GLFAVIKKVASVIGGL	activity value is IC50 = 6000000 uM||IC50= > 1 uM||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Escherichia coli, activity value is MIC = 100 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 25 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Pasteurella multocida, activity value is MIC > 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 25 ug/ml	Synthetic construct	N/A	N/A	12631273, 19464332	16	L
FPDB00769	4057|||4058|||4059|||4060|||4061|||4062|||4063|||4064|||4065|||DRAMP31590	GLFDVIKAVASVIGGL	activity value is IC50 = 5000000 uM||IC50= >100 uM||Antimicrobial||Anticancer	Amphibian skin secretions	N/A	N/A	Eur J Biochem. 2003 Mar;270(6):1141-53.	16	L
FPDB00770	4066|||Citropin-1.1|||DRAMP31591	GLFDVIKKVAAVIGGL	activity value is IC50 = 5000000 uM||Anti-Bacillus cereus, activity value is MIC = 50 ug/ml||Anti-Escherichia coli, activity value is MIC > 100 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 6 ug/ml||Anti-Listeria innocua, activity value is MIC > 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Pasteurella multocida, activity value is MIC > 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 25 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 25 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Amphibian skin secretions	N/A	N/A	12631273|||Eur J Biochem. 2003 Mar;270(6):1141-53.	16	L
FPDB00771	4084|||4085|||4086|||4087|||4088|||4089|||4090|||4091|||4092|||Citropin-1.1|||DRAMP31593	GLFDVIKKVASVIKKL	activity value is IC50 = 5000000 uM||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Escherichia coli, activity value is MIC > 100 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 50 ug/ml||Anti-Pasteurella multocida, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Amphibian skin secretions	N/A	N/A	12631273|||Eur J Biochem. 2003 Mar;270(6):1141-53.	16	L
FPDB00772	4093|||4094|||4095|||4096|||4097|||4098|||4099|||4100|||4101|||Citropin 1.1 M14	GLFDVIAKVASVIKKL	activity value is IC50 = 5000000 uM||Anti-E. faecalis Van-sens, activity value is MIC = 8 ug/ml||Anti-E. faecalis VanA, activity value is MIC = 8 ug/ml||Anti-E. faecalis VanB, activity value is MIC = 16 ug/ml||Anti-B. subtilis, activity value is MIC = 8 ug/ml||Anti-S. aureus H, activity value is MIC = 8 ug/ml||Anti-E. coli B, activity value is MIC = 128 ug/ml	Synthetic construct	N/A	Human RBC (IH50 = 256 ug/ml)	20564028	16	L
FPDB00773	4102|||4103|||4104|||4105|||4106|||4107|||4108|||4109|||4110|||Citropin-1.1|||DRAMP29006	GLFAVIKKVASVIKGL	activity value is IC50 = 5000000 uM||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Escherichia coli, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 12 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 6 ug/ml||Anti-Pasteurella multocida, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 6 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 25 ug/ml||Anti-Cancer cell lines: C4-2B, activity value is IC50 = 29.05 uM||Anti-A549, activity value is IC50 = 14.97 uM||Anti-U87, activity value is IC50 = 14.8 uM	Synthetic construct	Helicity = 61.5% in 50% 2,2,2-trifluoroethanol (TFE) aqueous solution (100 ug/ml)	Human umbilical vein endothelial cells HUVEC (IC50 at 6.4+-2.2 uM|||No hemolysis information or data found in the reference(s) presented in this entry	12631273, 30240951|||Front Chem. 2020 Dec 10;8:616147. doi: 10.3389/fchem.2020.616147. eCollection 2020.||Ref.33363118	16	L
FPDB00774	4111|||4112|||4113|||4114|||4115|||4116|||4117|||4118|||4119|||Citropin 1.1 M15|||DRAMP01591	GLFAVIKKVASVIKKL	activity value is IC50 = 5000000 uM||Anti-E. faecalis Van-sens, activity value is MIC = 8 ug/ml||Anti-E. faecalis VanA, activity value is MIC = 8 ug/ml||Anti-E. faecalis VanB, activity value is MIC = 16 ug/ml||Anti-B. subtilis, activity value is MIC = 8 ug/ml||Anti-S. aureus H, activity value is MIC = 8 ug/ml||Anti-E. coli B, activity value is MIC = 128 ug/ml||Anti-E. coli, activity value is MIC = 53 uM||Anti-S. aureus, activity value is MIC = 3 uM||Anti-B. subtilis, activity value is MIC = 3 uM	Synthetic construct|||Synthetic construc	N/A	Human RBC (IH50 = 128 ug/ml)	20564028	16	L
FPDB00775	4120|||4121|||4122|||4123|||4124|||4125|||4126|||4127|||4128|||Citropin 1.1|||DRAMP31594	GLFAVIKKVAAVIKKL	activity value is IC50 = 5000000 uM||Anti-Bacillus cereus, activity value is MIC = 100 ug/ml||Anti-Escherichia coli, activity value is MIC = 100 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 1.5 ug/ml||Anti-Listeria innocua, activity value is MIC = 12 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 25 ug/ml||Anti-Pasteurella multocida, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 3 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 12 ug/ml||Anti-Batrachochytrium dendrobatidis, activity value is MIC = 100||Antimicrobial||Anticancer	Synthetic construct|||Amphibian skin secretions	N/A	N/A	15784290, 12631273|||Eur J Biochem. 2003 Mar;270(6):1141-53.	16	L
FPDB00776	4129|||4130|||4131|||4132|||4133|||4134|||4135|||4136|||4137|||Citropin-1.1|||DRAMP31595	GLFAVIKKVAAVIRRL	activity value is IC50 = 5000000 uM||IC50= >10 uM||Anti-Bacillus cereus, activity value is MIC = 50 ug/ml||Anti-Escherichia coli, activity value is MIC > 100 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 12 ug/ml||Anti-Listeria innocua, activity value is MIC = 12 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 50 ug/ml||Anti-Pasteurella multocida, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Amphibian skin secretions	N/A	N/A	12631273|||Eur J Biochem. 2003 Mar;270(6):1141-53.	16	L
FPDB00777	4138|||4139|||Citropin-1.1|||DRAMP31596	GLFAVIKKVAKVIKKL	activity value is IC50 = 5000000 uM||activity value is IC50 = 6000000 uM||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Escherichia coli, activity value is MIC > 100 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC > 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 25 ug/ml||Anti-Pasteurella multocida, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Amphibian skin secretions	N/A	N/A	12631273|||Eur J Biochem. 2003 Mar;270(6):1141-53.	16	L
FPDB00778	4149|||4150|||4151|||4152|||4153|||4154|||4155|||Citropin 1.1 M20|||DRAMP31597	GLFKVIKKVASVIGGL	activity value is IC50 = 5000000 uM||IC50= >10 uM||Anti-E. faecalis Van-sens, activity value is MIC = 2 ug/ml||Anti-E. faecalis VanA, activity value is MIC = 2 ug/ml||Anti-E. faecalis VanB, activity value is MIC = 4 ug/ml||Anti-B. subtilis, activity value is MIC = 2 ug/ml||Anti-S. aureus H, activity value is MIC = 4 ug/ml||Anti-E. coli B, activity value is MIC = 128 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Amphibian skin secretions	N/A	Human RBC (IH50 = 256 ug/ml)	20564028|||Eur J Biochem. 2003 Mar;270(6):1141-53.	16	L
FPDB00779	4156|||4157|||4158|||4159|||4160|||4161|||4162|||4163|||4164|||Citropin-1.1|||DRAMP31598	GLFKVIKKVAKVIKKL	activity value is IC50 = 5000000 uM||IC50= >10 uM||Anti-Bacillus cereus, activity value is MIC = 50 ug/ml||Anti-Escherichia coli, activity value is MIC = 100 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 6 ug/ml||Anti-Listeria innocua, activity value is MIC = 25 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 25 ug/ml||Anti-Pasteurella multocida, activity value is MIC > 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml||Antimicrobial||Anticancer	Synthetic construct|||Amphibian skin secretions	N/A	N/A	12631273|||Eur J Biochem. 2003 Mar;270(6):1141-53.	16	L
FPDB00780	4165|||4166|||4167|||4168|||4169|||4170|||4171|||4172|||4173|||AP04793|||DRAMP31599	LGGIVSAVKKIVDFLG	activity value is IC50 = 5000000 uM||IC50= >10 uM||Anti-Gram+ E.faecalis PCM 2673, activity value is MIC = 128 ug/ml||Anti-S. aureus ATCC 25923 or 9144, activity value is MIC = 64 ug/ml||Anti-S.pneumoniae ATCC 49619, activity value is MIC = 128 ug/ml||Anti-E. coli ATCC 25922 or 23506, activity value is MIC = 64||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 32 ug/ml||Anti-P.aeruginosa ATCC 9027, activity value is MIC = 256 ug/ml||Anti-A.niger ATCC 16404, activity value is MIC = 256 ug/ml||Anti-C.albicans ATCC 10231, activity value is MIC = 128 ug/ml||Anti-and C.glabrata ATCC 15126, activity value is MIC = 256 ug/ml||Antimicrobial||Anticancer	sequence reversal, sequence shuffling, designed, man-made sequences|||Amphibian skin secretions	Helix	4% human RBC: no hemolysis at the MIC.	Amino Acids. 2017 Oct;49(10):1755-1771. doi: 10.1007/s00726-017-2473-7. PubMed|||Eur J Biochem. 2003 Mar;270(6):1141-53.	16	L
FPDB00781	4174|||4175|||4176|||4177|||4178|||4179|||4180|||4181|||4182|||4183|||DRAMP31609	KIFGSLAFL	0.1% Inhibition at 10000000-10000000 uM||1% Inhibition at 10000000-9000000 uM||5% Inhibition at 10000000-8000000 uM||10% Inhibition at 10000000-7000000 uM||20% Inhibition at 10000000-6000000 uM||8% Inhibition at 10000000-10000000 uM||25% Inhibition at 10000000-9000000 uM||80% Inhibition at 10000000-8000000 uM||85% Inhibition at 10000000-7000000 uM||92% Inhibition at 10000000-6000000 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Eur J Immunol. 2004 Mar;34(3):752-761.	9	L
FPDB00782	4184	HHPHG	activity value is IC50 = 92 uM	N/A	N/A	N/A	N/A	5	L
FPDB00783	4185|||4186	HHPHGHHPHG	activity value is IC50 = 11.6 uM||activity value is IC50 = 26.9 uM	N/A	N/A	N/A	N/A	10	L
FPDB00784	4187|||4188	HHPHGHHPHGHHPHG	activity value is IC50 = 1.25 uM||activity value is IC50 = 1.56 uM	N/A	N/A	N/A	N/A	15	L
FPDB00785	4189|||4190|||DRAMP31612	HHPHGHHPHGHHPHGHHPHG	activity value is IC50 = 0.256 uM||activity value is IC50 = 0.245 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Cancer Res. 2004 Aug 15;64(16):5812-7.	20	L
FPDB00786	4191|||4192|||4193|||4194|||CAMPSQ21821	GRKKRRQRRR	7% apoptosis at 10 uM||15% apoptosis at 20 uM||35% apoptosis at 30 uM||65% apoptosis at 50 uM||Antiviral	Synthetic construct	N/A	N/A	22319541	10	L
FPDB00787	4195|||4196|||4197|||4198|||DRAMP31615	GRKKRRQRRRGGWMWVTNLRTD	15% apoptosis at 10 uM||47% apoptosis at 20 uM||72% apoptosis at 30 uM||79% apoptosis at 50 uM||Antimicrobial||Anticancer	RasGAP-derived peptides	N/A	N/A	Oncogene. 2004 Nov 25;23(55):8971-8.	22	L
FPDB00788	4200|||DRAMP31618	HSHRDFQPVLHLVALNSPLSGGMRG	39% inhibition at 7000 ug/kg/d||Antimicrobial||Anticancer	Human endostatin peptides	N/A	N/A	Cancer Res. 2005 May 1;65(9):3656-63.	25	L
FPDB00789	4201|||DRAMP31619	MRGIRGADFQAFQQARAVGLAGTFR	19% inhibition at 7000 ug/kg/d||Antimicrobial||Anticancer	Human endostatin peptides	N/A	N/A	Cancer Res. 2005 May 1;65(9):3656-63.	25	L
FPDB00790	4202|||DRAMP31620	TFRAFLSSRLQDLYSIVRRADRAAV	No inhibition at 7000 ug/kg/d||Antimicrobial||Anticancer	Human endostatin peptides	N/A	N/A	Cancer Res. 2005 May 1;65(9):3656-63.	25	L
FPDB00791	4203|||DRAMP31621	AAVPIVNLKDELLFPSWEALFSGSE	No inhibition at 7000 ug/kg/d||Antimicrobial||Anticancer	Human endostatin peptides	N/A	N/A	Cancer Res. 2005 May 1;65(9):3656-63.	25	L
FPDB00792	4204|||DRAMP31622	GSEGPLKPGARIFSFDGKDVLRHPT	29% inhibition at 7000 ug/kg/d||Antimicrobial||Anticancer	Human endostatin peptides	N/A	N/A	Cancer Res. 2005 May 1;65(9):3656-63.	25	L
FPDB00793	4205|||DRAMP31623	HPTWPQKSVWHGSDPNGRRLTESY	No inhibition at 7000 ug/kg/d||Antimicrobial||Anticancer	Human endostatin peptides	N/A	N/A	Cancer Res. 2005 May 1;65(9):3656-63.	24	L
FPDB00794	4206|||DRAMP31624	ETWRTEAPSATGQASSLLGGRLLGQ	No inhibition at 7000 ug/kg/d||Antimicrobial||Anticancer	Human endostatin peptides	N/A	N/A	Cancer Res. 2005 May 1;65(9):3656-63.	25	L
FPDB00795	4207|||DRAMP31625	LGQSAASAHHAYIVLAIENSFMTASKKK	No inhibition at 7000 ug/kg/d||Antimicrobial||Anticancer	Human endostatin peptides	N/A	N/A	Cancer Res. 2005 May 1;65(9):3656-63.	28	L
FPDB00796	4219|||4220|||4221|||4222|||4223|||4224|||4225|||4226|||DRAMP31633	YSL	49.4% cytotoxic at 0.1 ug/ml||51.2% cytotoxic at 1 ug/ml||53.0% cytotoxic at 10 ug/ml||61.2% cytotoxic at 100 ug/ml||39.0% cytotoxic at 0.1 ug/ml||20.8% cytotoxic at 1 ug/ml||33.8% cytotoxic at 10 ug/ml||35.6% cytotoxic at 100 ug/ml||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Cancer Immunol Immunother. 2006 Jan;55(1):56-60.	3	L
FPDB00797	4475|||DRAMP31744	KAAKKWAKAAKKAAKAWKKAA	activity value is EC50 > 211 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	J Biol Chem. 2012 Jan 2;287(1):233-244.	21	L
FPDB00798	4476|||4486|||4496|||DRAMP31745	KAAKKWAKAWKKAAKAWKKAA	activity value is EC50 > 211 uM||activity value is EC50 = 173 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	J Biol Chem. 2012 Jan 2;287(1):233-244.	21	L
FPDB00799	4477|||4487|||4497|||DRAMP31742	KAAKKAWKAWKKAAKAAWKKAA	activity value is EC50 > 211 uM||activity value is EC50 = 128 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	J Biol Chem. 2012 Jan 2;287(1):233-244.	22	L
FPDB00800	4478|||4488|||4498|||DRAMP31740	KAAKKAWKAAKKAAKWWKKAA	activity value is EC50 = 155 uM||activity value is EC50 = 68 uM||activity value is EC50 = 173 uM||Antimicrobial||Anticancer	Synthetic	N/A	MRC-5: EC53=78 uM	J Biol Chem. 2012 Jan 2;287(1):233-244.	21	L
FPDB00801	4479|||4489|||4499|||DRAMP31743	KAAKKAWKWAKKAAKWAKKAA	activity value is EC50 = 42 uM||activity value is EC50 = 28 uM||activity value is EC50 = 67 uM||Antimicrobial||Anticancer	Synthetic	N/A	MRC-5: EC54=27 uM	J Biol Chem. 2012 Jan 2;287(1):233-244.	21	L
FPDB00802	4480|||4490|||4500|||DRAMP31746	KWWKKAAKAAKKAAKAAKKWA	activity value is EC50 = 17 uM||activity value is EC50 = 16 uM||activity value is EC50 = 31 uM||Antimicrobial||Anticancer	Synthetic	N/A	MRC-5: EC55=23 uM	J Biol Chem. 2012 Jan 2;287(1):233-244.	21	L
FPDB00803	4481|||4491|||4501|||DRAMP31741	KAAKKAWKAAKKAWKAAKKAA	activity value is EC50 = 15 uM||activity value is EC50 = 21 uM||Antimicrobial||Anticancer	Synthetic	N/A	MRC-5: EC56=20 uM	J Biol Chem. 2012 Jan 2;287(1):233-244.	21	L
FPDB00804	4482|||4492|||4502|||DRAMP31739	AWKKWAKAWKWAKAKWWAKAA	activity value is EC50 = 19 uM||activity value is EC50 = 14 uM||activity value is EC50 = 23 uM||Antimicrobial||Anticancer	Synthetic	N/A	MRC-5: EC57=17 uM	J Biol Chem. 2012 Jan 2;287(1):233-244.	21	L
FPDB00805	4483|||4493|||4503|||DRAMP31738	AAWKWAWAKKWAKAKKWAKAA	activity value is EC50 = 9 uM||activity value is EC50 = 16 uM||activity value is EC50 = 13 uM||Antimicrobial||Anticancer	Synthetic	N/A	MRC-5: EC58=14 uM	J Biol Chem. 2012 Jan 2;287(1):233-244.	21	L
FPDB00806	4484|||4494|||4504|||DRAMP31737	AAKKWAKAKWAKAKKWAKAA	activity value is EC50 > 211 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	J Biol Chem. 2012 Jan 2;287(1):233-244.	20	L
FPDB00807	4485|||4495|||DRAMP34919	KAAKKWAKAAKKWAKAWKKAA	activity value is EC50 = 186 uM||activity value is EC50 > 211 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	J Biol Chem. 2012 Jan 2;287(1):233-244.	21	L
FPDB00808	4532|||4533|||4534|||4535|||4536|||4537|||4538|||4539|||4540|||4541|||4542|||4543|||4544|||4545|||4546|||4547|||4548|||4549|||4550|||4571|||4574|||AP00783|||AP00783|||Pleurocidin-like peptide YT2|||DRAMP02359|||Pleurocidin-like peptide YT2|||AP00783	RWGKWFKKATHVGKHVGKAALTAYL	5% cytotoxic at 10 uM||20-30% cytotoxic at 25 uM||40-50% cytotoxic at 50 uM||~0% cytotoxic at 5 uM||10% cytotoxic at 10 uM||20% cytotoxic at 25 uM||20% cytotoxic at 10 uM||70-80% cytotoxic at 25 uM||80-85% cytotoxic at 50 uM||10% cytotoxic at 5 uM||50% cytotoxic at 10 uM||80% cytotoxic at 25 uM||80-90% cytotoxic at 50 uM||30-40% cytotoxic at 5 uM||60-70% cytotoxic at 10 uM||80-90% cytotoxic at 25 uM||85-90% cytotoxic at 50 uM||70% cytotoxic at 50 uM||60-70% cytotoxic at 50 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibacterial||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 4 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 2 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 2 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 4 ug/ml||Anti-E. coli UB1005, activity value is MIC = 4 ug/ml||Anti-E. coli DC2, activity value is MIC = 4 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus C623, activity value is MIC = 64 ug/ml||Anti-A. salmonicida 99-1, activity value is MIC = 4 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 2 ug/ml||Anti-E. coli CGSC 4908, activity value is MIC = 4 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 64 ug/ml||Anti-MRSA C623, activity value is MIC = 64 ug/ml||Anti-C. albicans C627, activity value is MIC = 16 ug/ml||Anti-A. salmonicida 99-1, activity value is MIC = 4 uM||Anti-A. salmonicida 97-4, activity value is MIC = 2 uM||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 uM||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 uM||Anti-P. aeruginosa K799, activity value is MIC = 4 uM||Anti-P. aeruginosa Z61, activity value is MIC = 2 uM||Anti-E. coli CGSC4908 or UB1005 or DC2, activity value is MIC = 4 uM||Anti-S. epidermidis C621 or MRSA, activity value is MIC = 64 uM||Anti-and C. albicans C627, activity value is MIC = 16 uM	Yellowtail flounder YT2, Pleuronectes ferruginea Storer|||Yellowtail flounder YT2, Pleuronectes ferruginea Storer|||Limanda ferruginea [Yellowtail flounder]|||Limanda ferruginea (Yellowtail flounder YT2)|||Limanda ferruginea [Yellowtail flounder]|||Yellowtail flounder YT2, Pleuronectes ferruginea Storer	N/A	A. salmonicida 99-1 ( MIC = 4 ug/ml), A. salmonicida 97-4 ( MIC = 2 ug/ml), S. enterica serovar Typhimurium MS7953s ( MIC = 2 ug/ml), S. enterica serovar Typhimurium 14028s ( MIC = 8 ug/ml), P. aeruginosa K799 ( MIC = 4 ug/ml), P. aeruginosa Z61 ( MIC = 2 ug/ml), E. coli CGSC 4908 ( MIC = 4 ug/ml), E. coli UB1005 ( MIC = 4 ug/ml), E. coli DC2 ( MIC = 4 ug/ml), S. epidermidis C621 ( MIC = 64 ug/ml), MRSA C623 ( MIC = 64 ug/ml), C. albicans C627 ( MIC = 16 ug/ml)	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.	25	L
FPDB00809	4551|||4552|||4553|||4554|||4555|||4556|||4557|||4558|||4559|||4560|||4561|||4562|||4563|||4564|||4565|||4566|||4567|||4568|||4569|||4572|||4575|||Pleurocidin-like peptide AP3|||NRC-13|||AP3|||DRAMP02362|||NRC-13	GWRTLLKKAEVKTVGKLALKHYL	~5% cytotoxic at 10 uM||10% cytotoxic at 25 uM||10-15% cytotoxic at 50 uM||~0% cytotoxic at 5 uM||~0% cytotoxic at 10 uM||10% cytotoxic at 5 uM||10% cytotoxic at 10 uM||10-15% cytotoxic at 25 uM||15-20% cytotoxic at 50 uM||~5% cytotoxic at 5 uM||5% cytotoxic at 25 uM||5-10% cytotoxic at 25 uM||20% cytotoxic at 50 uM||0% cytotoxic at 50 uM||~5% cytotoxic at 50 uM||Antibacterial||Antifungal||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 4 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 2 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 2 ug/ml||Anti-E. coli UB1005, activity value is MIC = 4 ug/ml||Anti-E. coli DC2, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus C623, activity value is MIC = 4 ug/ml||Anti-A. salmonicida 99-1, activity value is MIC = 4 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-E. coli CGSC4908, activity value is MIC = 2 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 4 ug/ml||Anti-MRSA C623, activity value is MIC = 4 ug/ml||Anti-C. albicans C627, activity value is MIC = 4 ug/ml	Hippoglossoides platessoides [American plaice]|||Glyptocephalus cynoglossus L. [Witch]|||Pleuronectes americanus [Fish]|||Hippoglossoides platessoides (American plaice AP3)	N/A	A. salmonicida 99-1 ( MIC = 4 ug/ml), A. salmoni- cida 97-4 ( MIC = 2 ug/ml), S. enterica serovar typhimurium MS7953s ( MIC = 2 ug/ml), S. enterica serovar typhimurium 14028s ( MIC = 8 ug/ml), P. aeruginosa K799 ( MIC = 4 ug/ml), P. aeruginosa Z61 ( MIC = 1 ug/ml), E. coli CGSC 4908 ( MIC = 2 ug/ml), E. coli UB1005 ( MIC = 4 ug/ml), E. coli DC2 ( MIC = 2 ug/ml), S. epidermidis C621 ( MIC = 4 ug/ml), MRSA C623 ( MIC = 4 ug/ml), C. albicans C627 ( MIC = 4 ug/ml)|||A. salmonicida 99-1 (MIC = 4 ug/ml), A. salmonicida 97-4 (MIC = 2 ug/ml), S. enterica serovar Typhimurium MS7953s (MIC = 2 ug/ml), S. enterica serovar Typhimurium 14028s (MIC = 8 ug/ml), P. aeruginosa K799 (MIC = 4 ug/ml), P. aeruginosa Z61 ( MIC = 1 ug/ml ), E. coli CGSC4908 (MIC = 2 ug/ml), E. coli UB1005 (MIC = 4 ug/ml), E. coli DC2 (MIC = 2 ug/ml), S. epidermidis C621 (MIC = 4 ug/ml), MRSA C623 (MIC=4 ug/ml), C. albicans C627 (MIC =4 ug/ml)|||S. aureus [MIC = 4.15 uM], E. coli [MIC = 8.3 uM], P. aeruginosa [MIC = 0.25 uM], K. pneumoniae [MIC = 4.15 uM]	12878506|||Reference: Wang, C, Sun Z, Liu Y, Zhang X, Xu G (2007) A novel antimicrobial vermipeptide family from earthworm Eisenia fetida. Eur. J Soil Biol 2007; 43:S217-S134.|||30845708|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.|||Reference: Wang, C, Sun Z, Liu Y, Zhang X, Xu G (2007) A novel antimicrobial vermipeptide family from earthworm Eisenia fetida. Eur. J Soil Biol 2007; 43:S217-S134.	23	L
FPDB00810	4576|||DRAMP31733	LIAHNQVRQV	Antimicrobial||Anticancer	Synthetic	N/A	N/A	Cancer Immunol Immunother. 2012 Mar;61(3):397-407.	10	L
FPDB00811	4577|||DRAMP31732	GVGSPYVSRLLGICL	Antimicrobial||Anticancer	Synthetic	N/A	N/A	Cancer Immunol Immunother. 2012 Mar;61(3):397-407.	15	L
FPDB00812	4578|||DRAMP31724	PRFWEYWLRLME	activity value is IC50 = 0.01 uM||Antimicrobial||Anticancer	E13 ubiquitin-protein ligase	N/A	N/A	PLoS One. 2011 Mar 15;6(3):e17898.	12	L
FPDB00813	4579|||DRAMP31714|||DRAMP31715|||DRAMP35129|||DRAMP35130	LTFEHYWAQLTS	activity value is IC50 = 0.29 uM||Antimicrobial||Anticancer	E3 ubiquitin-protein ligase|||E4 ubiquitin-protein ligase|||Synthetic	N/A	N/A	PLoS One. 2011 Mar 15;6(3):e17898.|||Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3445-55.	12	L
FPDB00814	4580|||DRAMP31716	LTAEHYAAQATS	activity value is IC50 > 100 uM||Antimicrobial||Anticancer	E5 ubiquitin-protein ligase	N/A	N/A	PLoS One. 2011 Mar 15;6(3):e17898.	12	L
FPDB00815	4581|||DRAMP31717	QETFSDLWKLLP	activity value is IC50 = 4.7 uM||Antimicrobial||Anticancer	E6 ubiquitin-protein ligase	N/A	N/A	PLoS One. 2011 Mar 15;6(3):e17898.	12	L
FPDB00816	1441|||1443|||DRAMP31601	KLlRLLkkLlRLlLK	LC50 = 2.5 uM||LC50= 4.5 uM||Antimicrobial||Anticancer	Diastereomeric peptide	N/A	Human erythrocyte: Hemolysis% at 50 μm peptide LC50=0 uM	J Biol Chem. 2003 Jun 6;278(23):21018-23.	15	Mix
FPDB00817	1442	KlllKLKlKlLK	LC50 = 100 uM	N/A	N/A	N/A	N/A	12	Mix
FPDB00818	1444|||CAMPSQ18535|||DRAMP31600	KLllKLKlKlLK	LC50 = >50 uM||Antibacterial||Antimicrobial||Anticancer	Synthetic construct|||Diastereomeric peptide	N/A	Human erythrocyte: Hemolysis% at 50 μm peptide LC50=0 uM	9169426, 24419338|||J Biol Chem. 2003 Jun 6;278(23):21018-23.	12	Mix
FPDB00819	1530	FKRiVQRiKDFlRNLV	N/A	N/A	N/A	N/A	N/A	16	Mix
FPDB00820	1789|||1941|||2093|||2245|||2397|||2540|||2683	FALALKALKKALkkLKKALKKAL	activity value is LD50 = 14 ug||activity value is LD50 = 57 ug/ml||activity value is LD50 = 150 ug/ml||activity value is LD50 = 64 ug/ml	N/A	N/A	N/A	N/A	23	Mix
FPDB00821	2855|||2856|||2857|||2858|||2859|||2860|||2861|||2901|||2902|||2903|||2904|||2905|||2906|||2907|||2908|||2909|||2910|||2911|||2912	KLlLKlLkkLLKlLKKK	activity value is IC50 = 37.1 uM||activity value is IC50 = 28.0 uM||activity value is IC50 = 37.4 uM||activity value is IC50 = 77.3 uM||activity value is IC50 = 30.5 uM||activity value is IC50 = 27.1 uM||activity value is IC50 = 18.5 uM||activity value is IC50 = 34.5 uM||activity value is IC50 = 14.1 uM||activity value is IC50 = 25.7 uM||activity value is IC50 = 27 uM||activity value is IC50 = 20 uM||activity value is IC50 = 19.4 uM||activity value is IC50 = 19.1 uM||activity value is IC50 = 21.9 uM||activity value is IC50 = 17 uM||activity value is IC50 = 17.1 uM||activity value is IC50 = 15.8 uM||activity value is IC50 = 13.5 uM	N/A	N/A	N/A	N/A	17	Mix
FPDB00822	2862|||2863|||2864|||2865|||2866|||2867|||2868	KQLIRFLKRLDRNGGGKLlLKlLkkLLKlLKKK	activity value is IC50 = 6.8 uM||activity value is IC50 = 7.5 uM||activity value is IC50 = 13.2 uM||activity value is IC50 = 18.5 uM||activity value is IC50 = 3.6 uM||activity value is IC50 = 5.7 uM	N/A	N/A	N/A	N/A	33	Mix
FPDB00823	2869|||2870|||2871|||DRAMP31636	LKlLKKLlkKLLkLL	LC50=6 uMol/L||LC50=3 uMol/L||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Cancer Immunol Immunother. 2006 Jan;55(1):56-60.	15	Mix
FPDB00824	2913|||2914|||2915|||2916|||2917|||2918|||2919|||2920|||2921|||2922|||2923|||2924	THRPPMWSPVWPGGGKLlLKlLkkLLKlLKKK	activity value is IC50 = 8.8 uM||activity value is IC50 = 4 uM||activity value is IC50 = 6.5 uM||activity value is IC50 = 7.8 uM||activity value is IC50 = 4.8 uM||activity value is IC50 = 9.3 uM||activity value is IC50 = 6.3 uM||activity value is IC50 = 7 uM||activity value is IC50 = 8.3 uM||activity value is IC50 = 6.2 uM||activity value is IC50 = 6.4 uM	N/A	N/A	N/A	N/A	32	Mix
FPDB00825	3206|||3207|||3216|||3217|||DRAMP31790	KVKVKVKVpPTKVKVKVK	activity value is IC50 = 8.1||activity value is IC50 = 5.6||Antimicrobial||Anticancer	Synthetic	N/A	Human erythrocytes: 50% Hemolysis=80.8±12.8 uM	J Am Chem Soc. 2012 Apr 11;134(14):6210-7.	18	Mix
FPDB00826	3218|||3219|||3220|||3221|||DRAMP31791	kvkvkvkvPptkvkvkvk	activity value is IC50 = 3.2||activity value is IC50 = 4.5||activity value is IC50 = 4.7||Antimicrobial||Anticancer	Synthetic	N/A	N/A	J Am Chem Soc. 2012 Apr 11;134(14):6210-7.	18	Mix
FPDB00827	3756|||DRAMP18515	KWKSFLkTFKSLKKTVLHTLLKAISS	activity value is IC50 = 1.29||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 62.5 ug/ml||Anti-Pseudomonas aeruginosa WR5, activity value is MIC = 125 ug/ml||Anti-Pseudomonas aeruginosa PAK, activity value is MIC = 62.5 ug/ml||Anti-Pseudomonas aeruginosa PA14, activity value is MIC = 125 ug/ml||Anti-Pseudomonas aeruginosa M2, activity value is MIC = 62.5 ug/ml||Anti-Pseudomonas aeruginosa CP204, activity value is MIC = 62.5 ug/ml||Anti-The geometric mean of MIC values above six Gram-negative strains, activity value is MIC = 78.7 ug/ml	Synthetic construct	Alpha helix	[Ref.22837667]MHC=8 ug/ml, MHC=5.2±0.02 uM against human red blood cells	Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406.##Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.17158938||Ref.22837667	26	Mix
FPDB00828	3757|||DRAMP18516	KWKSFLKTFKSLKkTVLHTLLKAISS	activity value is IC50 = 1.52||Anti-Cancer cell: HeLa cell, activity value is IC50 = 1.29	Synthetic construct	Alpha helix	[Ref.22837667]MHC=10.4±0.04 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00829	3758|||DRAMP18517	KWKSFLKTFKSLKKTVLHTLLkAISS	activity value is IC50 = 1.39||Anti-Cancer cell: HeLa cell, activity value is IC50 = 1.52	Synthetic construct	Alpha helix	[Ref.22837667]MHC=5.2±0.02 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00830	3759|||3761|||DRAMP18518	KWKSFLkTFKSLKkTVLHTLLKAISS	activity value is IC50 = 2.06||activity value is IC50 = 4.45||Anti-Cancer cell: HeLa cell, activity value is IC50 = 1.39	Synthetic construct	Alpha helix	[Ref.22837667]MHC=20.81±0.1 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00831	3760|||DRAMP18519	KWKSFLKTFKSLKkTVLHTLLkAISS	activity value is IC50 = 1.40||Anti-Cancer cell: HeLa cell, activity value is IC50 = 2.06	Synthetic construct	Alpha helix	[Ref.22837667]MHC=20.81±0.15 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00832	3762|||DRAMP18521|||DRAMP18522	KWKSFLkTFkSLKkTVLHTLLkAISS	activity value is IC50 = 4.79||Anti-Cancer cell: HeLa cell, activity value is IC50 = 4.45||Anti-Cancer cell: HeLa cell, activity value is IC50 = 4.79	Synthetic construct	Alpha helix	[Ref.22837667]MHC=81.31±0.17 uM against human red blood cells|||[Ref.22837667]MHC=325.2±0.82 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00833	3763|||DRAMP18523	KWkSFLkTFkSLKkTVLHTLLkAISS	activity value is IC50 = 20.41||Anti-Cancer cell: HeLa cell, activity value is IC50 = 20.41	Synthetic construct	Alpha helix	[Ref.22837667]MHC>325.2 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00834	3764|||DRAMP18524	kWkSFLkTFkSLKkTVLHTLLkAISS	activity value is IC50 = 18.07||Anti-Cancer cell: HeLa cell, activity value is IC50 = 18.07	Synthetic construct	Alpha helix	[Ref.22837667]MHC>325.2 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00835	3765|||DRAMP31805	KWKSFlKTFKSLKKTVLHTLLKAISS	activity value is IC50 = 2.23||Antimicrobial||Anticancer	Acetylation	N/A	Human red blood cells: MHC=10.4±0.08 uM	Int J Mol Sci. 2012;13(6):6849-6862.	26	Mix
FPDB00836	3766|||DRAMP31803	KWKSFLKTFKSlKKTVLHTLLKAISS	activity value is IC50 = 2.63||Antimicrobial||Anticancer	Acetylation	N/A	Human red blood cells: MHC=20.81±0.03 uM	Int J Mol Sci. 2012;13(6):6849-6862.	26	Mix
FPDB00837	3767|||DRAMP31804	KWKSFLKTFKSLKKTVLHTlLKAISS	activity value is IC50 = 2.33||Antimicrobial||Anticancer	Acetylation	N/A	Human red blood cells: MHC=20.81 +0.13 uM	Int J Mol Sci. 2012;13(6):6849-6862.	26	Mix
FPDB00838	3768|||DRAMP18528	KWKSFlKTFKSlKKTVLHTLLKAISS	activity value is IC50 = 3.01||Anti-Cancer cell: HeLa cell, activity value is IC50 = 3.01	Synthetic construct	Alpha helix	[Ref.22837667]MHC=20.81±0.1 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00839	3769|||DRAMP18529	KWKSFLKTFKSlKKTVLHTlLKAISS	activity value is IC50 = 3.14||Anti-Cancer cell: HeLa cell, activity value is IC50 = 3.14	Synthetic construct	Alpha helix	[Ref.22837667]MHC=81.31±0.43 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00840	3770|||DRAMP18530	KWKSFlKTFKSlKKTVLHTlLKAISS	activity value is IC50 = 7.80||Anti-Cancer cell: HeLa cell, activity value is IC50 = 7.8	Synthetic construct	Alpha helix	[Ref.22837667]MHC=162.61±0.19 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00841	3771|||DRAMP18531	KWKSFlKTFKSlKKTVlHTlLKAISS	activity value is IC50 = 9.69||Anti-Cancer cell: HeLa cell, activity value is IC50 = 9.69	Synthetic construct	Alpha helix	[Ref.22837667]MHC=81.31±1.05 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00842	3772|||DRAMP18532	KWKSFlKTFKSlKKTVlHTllKAISS	activity value is IC50 = 12.88||Anti-Cancer cell: HeLa cell, activity value is IC50 = 12.88	Synthetic construct	Alpha helix	[Ref.22837667]MHC>325.2 uM against human red blood cells	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.||Ref.22837667	26	Mix
FPDB00843	4227|||4228|||4229|||4230|||4231|||4232|||4233|||4234|||4235|||4236|||4237|||4238	rrrrrrrrGNLWAAQRYGRELRRMSDEFVDSFKK	0% apoptosis at 10 uM||10% apoptosis at 20 uM||30% apoptosis at 50 uM||30% apoptosis at 10 uM||80% apoptosis at 20 uM||80% apoptosis at 50 uM||20% apoptosis at 10 uM||>50% apoptosis at 20 uM||15% apoptosis at 10 uM||20% apoptosis at 20 uM||50% apoptosis at 50 uM	N/A	N/A	N/A	N/A	34	Mix
FPDB00844	4239|||4240|||4241|||4242|||4243|||4244|||4245|||4246|||4247|||4248|||4249|||4250|||DRAMP31634	rrrrrrrrGEDIIRNIARHLAQVGDSMDR	8% apoptosis at 10 uM||45% apoptosis at 20 uM||65% apoptosis at 50 uM||25% apoptosis at 10 uM||66% apoptosis at 20 uM||68% apoptosis at 50 uM||43% apoptosis at 10 uM||46% apoptosis at 20 uM||79% apoptosis at 50 uM||23% apoptosis at 10 uM||35% apoptosis at 20 uM||55% apoptosis at 50 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Cancer Immunol Immunother. 2006 Jan;55(1):56-60.	29	Mix
FPDB00845	4251|||4252|||4253|||4254|||4255|||4256|||4257|||4258|||4259|||4260|||4261|||4262|||DRAMP31635	rrrrrrrrGEDIIRNIARHAAQVGASMDR	1% apoptosis at 10 uM||2% apoptosis at 20 uM||3% apoptosis at 50 uM||2% apoptosis at 10 uM||1% apoptosis at 20 uM||5% apoptosis at 50 uM||0% apoptosis at 10 uM||2% apoptosis at 50 uM||Antimicrobial||Anticancer	Synthetic	N/A	N/A	Cancer Immunol Immunother. 2006 Jan;55(1):56-60.	29	Mix
FPDB00846	4263|||4264|||4266|||4267|||4269|||4270|||4272|||4273|||Undefined	lKKllKKllKKl	LC50>100 uM||LC50<3.125 uM||LC50=3.125 uM||Anti-Candida albicans ATCC 10231, activity value is MIC > 50 uM||Anti-Cryptococcus neoformans ATCC 26430, activity value is MIC > 50 uM||Anti-Aspergillus fumigatus ATCC MY A-422, activity value is MIC = 50 uM||Anti-Staphylococcus aureus ATCC 6538P, activity value is MIC > 50 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 50 uM||Anti-Escherichia coli ATCC 35218, activity value is MIC > 50 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 25 uM||Anti-Cryptococcus neoformans ATCC 26430, activity value is MIC = 1.56 uM||Anti-Aspergillus fumigatus ATCC MY A-422, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus ATCC 6538P, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 12.5 uM||Anti-Escherichia coli ATCC 35218, activity value is MIC = 12.5 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 3.12 uM||Anti-Cryptococcus neoformans ATCC 26430, activity value is MIC = 0.78 uM||Anti-Aspergillus fumigatus ATCC MY A-422, activity value is MIC = 6.25 uM||Anti-Staphylococcus aureus ATCC 6538P, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 25 uM||Anti-Escherichia coli ATCC 35218, activity value is MIC = 25 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 1.56 uM||Anti-Aspergillus fumigatus ATCC MY A-422, activity value is MIC = 1.56 uM||Anti-Staphylococcus aureus ATCC 6538P, activity value is MIC = 50 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 50 uM||Anti-Escherichia coli ATCC 35218, activity value is MIC = 50 uM||Anti-Escherichia coli K-12, activity value is MIC = 7.81 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 31.3 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 7.81 uM||Anti-Staphylococcus aureus 8325-4, activity value is MIC = 15.6 uM||Anti-Staphylococcus aureus, activity value is MIC = 62.5 uM||Anti-Pseudomonas aeruginosa PA-W1, activity value is MIC = 15.6 uM	Synthetic construct	N/A	Human erythrocytes (50% Hemolysis at >2000 uM	15907192, 28457962	12	Mix
FPDB00847	4275|||4276	lRRllRRllRRl	LC50=50 uM||LC50>100 uM	N/A	N/A	N/A	N/A	12	Mix
FPDB00848	4278|||4279	DDAlRRllRRllRRl	LC50=3.125 uM	N/A	N/A	N/A	N/A	15	Mix
FPDB00849	4335|||4336|||4337|||4338|||4339|||4340|||4599|||4600	YHWYGYTPQNVIGGGKLlLKlLkkLLKlLKKK	activity value is IC50 = 6.8 uM||activity value is IC50 = 6.5 uM||activity value is IC50 = 12 uM||activity value is IC50 = 10 uM||activity value is IC50 = 0.12 uM||activity value is IC50 = 0.46 uM	N/A	N/A	N/A	N/A	32	Mix
FPDB00850	4341|||4342|||4343|||4344|||4345|||4346	YRWYGYTPQNVIGGGKLlLKlLkkLLKlLKKK	activity value is IC50 = 3.2 uM||activity value is IC50 = 1.9 uM||activity value is IC50 = 8.4 uM||activity value is IC50 = 6.6 uM||activity value is IC50 = 7.4 uM||activity value is IC50 = 4.8 uM	N/A	N/A	N/A	N/A	32	Mix
FPDB00851	4347|||4348|||4349|||4350	NYQWVPYQGRVPYPRGGLLkLLKklLKKLlKL	activity value is IC50 = 12.5 uM||activity value is IC50 = 10.6 uM||activity value is IC50 = 13.1 uM||activity value is IC50 = 7.9 uM	N/A	N/A	N/A	N/A	32	Mix
FPDB00852	4351|||4352|||4353|||4354	GRVPYPRGGLLkLLKklLKKLlKL	activity value is IC50 = 14.7 uM||activity value is IC50 = 9.2 uM||activity value is IC50 = 14.1 uM||activity value is IC50 = 8 uM	N/A	N/A	N/A	N/A	24	Mix
FPDB00853	4199	lw	ID50=10.1 ug/ml	N/A	N/A	N/A	N/A	2	D
FPDB00854	3157|||3158|||3159|||3160|||DRAMP35057	WRWRWRWRW	62-73% inhibition of cell proliferation at 1 uM||51-74% inhibition of cell proliferation at 1 uM||50-67% inhibition of cell proliferation at 1 uM||60-79% inhibition of cell proliferation at 1 uM||Antimicrobial||Anticancer	N/A	N/A	N/A	Mol Pharm. 2013 Feb 4;10(2):488-99.	9	L
FPDB00855	3161|||3162|||3163|||3164|||DRAMP03918	RWRWRWRW	46-69% antiproliferative activity at 1 uM||28-34% antiproliferative activity at 1 uM||21-61% antiproliferative activity at 1 uM||60-74% antiproliferative activity at 1 uM||Antimicrobial||Antifungal	Synthetic construct (De novo design)	N/A	N/A	Int J Mol Sci. 2012; 13(11): 15042-15053.	8	L
FPDB00856	3189	(K-Aib-C(CH2CO-2'-Pac))2	activity value is IC50 = 0.00131 uM	N/A	N/A	N/A	N/A	12	L
FPDB00857	3190|||3192|||3193|||3194	(K-Aib-C(CH2CO-2'-Pac))3	activity value is IC50 = 0.00285 uM||activity value is IC50 = 0.0017 uM||activity value is IC50 = 0.00388 uM||activity value is IC50 = 0.003 uM	N/A	N/A	N/A	N/A	12	L
FPDB00858	3191|||3195|||3196|||3197	(K-Aib-C(CH2CO-2'-Pac))4	activity value is IC50 = 0.00062 uM||activity value is IC50 = 0.00096 uM||activity value is IC50 = 0.0013 uM||activity value is IC50 = 0.00064 uM	N/A	N/A	N/A	N/A	12	L
FPDB00859	3305|||3306|||3307	WKKW-Dip-KKWK	activity value is IC50 = 75||activity value is IC50 = 73||activity value is IC50 = 28	N/A	N/A	N/A	N/A	11	L
FPDB00860	3308|||3309|||3310|||5012|||5013|||5014	KKWWKKW-Dip-K	activity value is IC50 = 38||activity value is IC50 = 31||activity value is IC50 = 14||activity value is IC50 = 13.3 uM||activity value is IC50 = 12.7 uM||activity value is IC50 = 15.3 uM	N/A	N/A	N/A	N/A	11	L
FPDB00861	3311|||3312|||3313	OOW-Dip-OOWWO	activity value is IC50 = 248||activity value is IC50 = 216||activity value is IC50 = 78	N/A	N/A	N/A	N/A	11	L
FPDB00862	3507|||3532|||3557	VN-Nal-KKLLGKLLKVVK	activity value is IC50 = 6	N/A	N/A	N/A	N/A	17	L
FPDB00863	3510|||3535|||3560	VNWKK-Aib-LGK-Aib-IK-Aib-VK	activity value is IC50 = 3||activity value is IC50 = 28 uM||activity value is IC50 = 8	N/A	N/A	N/A	N/A	21	L
FPDB00864	3511|||3536|||3561	KNWKK-Aib-LKK-Aib-IK-Aib-VK	activity value is IC50 = 11||activity value is IC50 > 100 uM||activity value is IC50 = 25	N/A	N/A	N/A	N/A	21	L
FPDB00865	3599|||3615|||3631	GFGMALKL-(AC6C)-KKVL	activity value is IC50 = 8||activity value is IC50 = 16||activity value is IC50 = 11 uM	N/A	N/A	N/A	N/A	15	L
FPDB00866	3600|||3616|||3632	GFGMALK-(AC6C)-LKKVL	activity value is IC50 = 7||activity value is IC50 = 14||activity value is IC50 = 12	N/A	N/A	N/A	N/A	15	L
FPDB00867	3601|||3617|||3633	GFGMA-(AC6C)-KLLKKVL	activity value is IC50 = 8||activity value is IC50 = 18||activity value is IC50 = 9	N/A	N/A	N/A	N/A	15	L
FPDB00868	3773|||3781	KKW tail 2, 2W KKK	N/A	N/A	N/A	N/A	N/A	11	L
FPDB00869	3774|||3776|||3778|||3780|||3782|||3784|||3786|||3788|||OLAP-362	KW	Anti-Escherichia coli UB1005, activity value is MIC > 2000 ug/ml||Anti-Staphylococcus aureus SAP 0017, activity value is MIC > 2000 ug/ml||Anti-Candida albicans 105, activity value is MIC > 2000 ug/ml||Anti-Cutibacterium acnes, activity value is MIC > 2000 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus ATCC 33591, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis ATCC 27626, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 75 ug/ml||Anti-Staphylococcus aureus ATCC 33591, activity value is MIC = 50 ug/ml	Synthetic construct	N/A	Human erythrocytes (- at NA , Human erythrocytes (- at NA	N/A	2	L
FPDB00870	3775|||3779|||3783|||3787|||OLAP-344|||Undefined	KK	Anti-Staphylococcus aureus, activity value is MIC = 2||Anti-Staphylococcus aureus, activity value is MBC = 2||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus ATCC 29213, activity value is MBC = 16 ug/ml||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus ATCC 43300, activity value is MBC = 16 ug/ml||Anti-Staphylococcus aureus MR, activity value is MIC = 2||Anti-Staphylococcus aureus MR, activity value is MBC = 2||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 4 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MBC = 8 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 2||Anti-Enterococcus faecalis, activity value is MBC = 2||Anti-Enterococcus faecalis VR, activity value is MIC = 2||Anti-Enterococcus faecalis VR, activity value is MBC = 2||Anti-Streptococcus pyogenes, activity value is MIC = 1||Anti-Streptococcus pyogenes, activity value is MBC = 2||Anti-Streptococcus pyogenes ATCC 19615, activity value is MIC = 2 ug/ml||Anti-Streptococcus pyogenes ATCC 19615, activity value is MBC = 4 ug/ml||Anti-Rhodococcus equi, activity value is MIC = 2||Anti-Rhodococcus equi, activity value is MBC = 4||Anti-Rhodococcus equi ATCC 6939, activity value is MIC = 16 ug/ml||Anti-Rhodococcus equi ATCC 6939, activity value is MBC = 32 ug/ml||Anti-Enterococcus faecalis ATCC 51299, activity value is MIC = 4 ug/ml||Anti-Enterococcus faecalis ATCC 51299, activity value is MBC = 16 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 4||Anti-Microsporum canis, activity value is MIC = 0.06||Anti-Microsporum canis, activity value is MFC = 16||Anti-Trichophyton rubrum, activity value is MIC = 0.015||Anti-Trichophyton rubrum, activity value is MFC = 16||Anti-Trichophyton mentagrophytes, activity value is MIC = 0.5||Anti-Trichophyton mentagrophytes, activity value is MFC = 16||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MBC = 16 ug/ml||Anti-Proteus mirabilis PCM 543, activity value is MIC = 256 ug/ml||Anti-Proteus mirabilis PCM 543, activity value is MBC = 512 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 64 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MBC = 64 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 16 ug/ml||Anti-Staphylococcus epidermidis PCM 2118, activity value is MIC = 1 ug/ml||Anti-Staphylococcus epidermidis PCM 2118, activity value is MBC = 1 ug/ml||Anti-Streptococcus pneumoniae ATCC 49619, activity value is MIC = 8 ug/ml||Anti-Streptococcus pneumoniae ATCC 49619, activity value is MBC = 16 ug/ml||Anti-Streptococcus pyogenes PCM 465, activity value is MIC = 8 ug/ml||Anti-Streptococcus pyogenes PCM 465, activity value is MBC = 16 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus SAP 0017, activity value is MIC = 4 ug/ml||Anti-Candida albicans 105, activity value is MIC = 16 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis ATCC 14490, activity value is MIC = 4 ug/ml||Anti-Klebsiella pneumoniae ATCC 200603, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 128 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 128 ug/ml||Anti-Candida tropicalis PCM 2681, activity value is MIC = 128 ug/ml||Anti-Rhodococcus equi, activity value is MBC = 2||Anti-Rhodococcus equi ATCC 6939, activity value is MIC = 8 ug/ml||Anti-Rhodococcus equi ATCC 6939, activity value is MBC = 16 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus SAP 0017, activity value is MIC = 16 ug/ml||Anti-Candida albicans 105, activity value is MIC = 64 ug/ml||Anti-Cutibacterium acnes, activity value is MIC = 1||Anti-Staphylococcus aureus USA 300, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 50 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 3.1 uM||Anti-Klebsiella pneumoniae, activity value is MIC > 50 uM||Anti-Staphylococcus aureus USA 200, activity value is MIC = 6.25 uM||Anti-Staphylococcus aureus USA 400, activity value is MIC = 6.25 uM||Anti-Staphylococcus aureus UAMS-1, activity value is MIC = 6.25 uM||Anti-Staphylococcus aureus MU50, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus Newman, activity value is MIC = 6.25 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 6.25 uM||Anti-Candida albicans ATCC 10231, activity value is MIC > 25 uM||Anti-Candida glabrata ATCC 2001, activity value is MIC = 25 uM||Anti-Candida tropicalis ATCC 13803, activity value is MIC = 6.25 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 64 ug/ml||Anti-Staphylococcus epidermidis PCM 2118, activity value is MIC = 4 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 4 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 32 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 64 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 128 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 32 ug/ml||Anti-Proteus vulgaris PCM 2668, activity value is MIC > 512 ug/ml||Anti-Candida tropicalis PCM 2681, activity value is MIC = 256 ug/ml||Anti-Aspergillus niger ATCC 16404, activity value is MIC = 256 ug/ml||Anti-Staphylococcus aureus USA 300, activity value is MIC = 100 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC > 200 uM||Anti-Escherichia coli K-12, activity value is MIC = 100 uM||Anti-Bacillus subtilis, activity value is MIC = 100 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 2000 ug/ml||Anti-Staphylococcus epidermidis PCM 2118, activity value is MIC = 64 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 64 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 512 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2000 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 2000 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 2000 ug/ml||Anti-Proteus vulgaris PCM 2668, activity value is MIC > 2000 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 1000 ug/ml||Anti-Candida tropicalis PCM 2681, activity value is MIC = 1000 ug/ml||Anti-Aspergillus niger ATCC 16404, activity value is MIC = 2000 ug/ml||Anti-Staphylococcus aureus USA 300, activity value is MIC > 200 uM||Anti-Escherichia coli K-12, activity value is MIC > 200 uM||Anti-Bacillus subtilis, activity value is MIC > 200 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 2000 ug/ml||Anti-Staphylococcus epidermidis PCM 2118, activity value is MIC = 256 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 256 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC > 2000 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC > 2000 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC > 2000 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 2000 ug/ml||Anti-Aspergillus niger ATCC 16404, activity value is MIC = 1000 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 1000 ug/ml||Anti-Staphylococcus epidermidis PCM 2118, activity value is MIC > 1000 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC > 1000 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC > 1000 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC > 1000 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC > 1000 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC > 2000 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 25 uM||Anti-Enterobacter cloacae ATCC 49141, activity value is MIC = 50 uM||Anti-Acinetobacter baumannii ATCC 19606, activity value is MIC = 75 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-Enterococcus faecalis ATCC 19433, activity value is MIC = 25 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 9.4 uM||Anti-Aspergillus fumigatus ATCC 26430, activity value is MIC = 6.2 uM	Synthetic construct	N/A	Human erythrocytes (10% Hemolysis at 16 ug/ml, Human erythrocytes (50% Hemolysis at 50 uM, Human erythrocytes (10% Hemolysis at 128 ug/ml, Human erythrocytes (10% Hemolysis at >4000 ug/ml, Human erythrocytes (10% Hemolysis at 4000 ug/ml, Human erythrocytes (22% Hemolysis at 100 uM	https://pubmed.ncbi.nlm.nih.gov/27226784,	2	L
FPDB00871	3777|||3785	KKW	N/A	N/A	N/A	N/A	N/A	3	L
FPDB00872	3847|||3848|||3849|||3850|||3851|||3852|||3853|||3854|||3855|||3856|||3857|||3858|||3859|||3860|||3861|||3862|||3863|||3864|||3865|||3866|||3867|||3868|||3869|||3870|||3871	YA*	14.2% inhibition at 10-6||19.7% inhibition at 10-5||24.9% inhibition at 10-4||30.4% inhibition at 10-3||10% inhibition at 10-5||8.2% inhibition at 10-4||36.1% inhibition at 10-3||6.5% inhibition at 10-6||14% inhibition at 10-5||7.5% inhibition at 10-4||14% inhibition at 10-3||9.8% inhibition at 10-6||1.6% inhibition at 10-5||5.4% inhibition at 10-4||26.5% inhibition at 10-3||12.9% inhibition at 10-6||16.5% inhibition at 10-5||28.1% inhibition at 10-4||58.2% inhibition at 10-3||3.5% inhibition at 10-6||22.7% inhibition at 10-5||18.9% inhibition at 10-4||26.4% inhibition at 10-3||2.4% inhibition at 10-5	N/A	N/A	N/A	N/A	2	L
FPDB00873	3872|||3873|||3874|||3875|||3876|||3877|||3878|||3879|||3880|||3881|||3882|||3883|||3884|||3885|||3886|||3887|||3888|||3889|||3890|||3891|||3892|||3893|||3894|||3895|||3896|||3897|||3898|||3899|||3900|||3901|||3902|||3903|||3904|||3905|||3906|||3907|||3908|||3909|||3910|||3911|||3912|||3913|||3914|||3915|||3916	YSA*	6.2% inhibition at 10-6||6.4% inhibition at 10-5||8.2% inhibition at 10-4||21.2% inhibition at 10-3||7.5% inhibition at 10-6||6.1% inhibition at 10-5||3.1% inhibition at 10-4||14.8% inhibition at 10-3||3.9% inhibition at 10-5||7.3% inhibition at 10-3||4.9% inhibition at 10-6||8.9% inhibition at 10-5||3.4% inhibition at 10-4||20.8% inhibition at 10-3||10.5% inhibition at 10-6||21.9% inhibition at 10-5||11.8% inhibition at 10-4||17.9% inhibition at 10-3||3.7% inhibition at 10-6||16.5% inhibition at 10-5||8.4% inhibition at 10-4||14.5% inhibition at 10-3||1.1% inhibition at 10-5||1.2% inhibition at 10-4||17.8% inhibition at 10-3||8.5% inhibition at 10-6||4.9% inhibition at 10-5||1.9% inhibition at 10-4||16.2% inhibition at 10-3||7.2% inhibition at 10-6||17.1% inhibition at 10-5||11.0% inhibition at 10-4||20.5% inhibition at 10-3||3.0% inhibition at 10-6||4.7% inhibition at 10-5||2.7% inhibition at 10-4||0.7% inhibition at 10-6||8.3% inhibition at 10-5||10.5% inhibition at 10-4||21.8% inhibition at 10-3||10.7% inhibition at 10-6||10.0% inhibition at 10-5||7.7% inhibition at 10000000-4000000 uM||18.7% inhibition at 10000000-3000000 uM	N/A	N/A	N/A	N/A	3	L
FPDB00874	3917|||3918|||3919|||3920|||3921|||3922|||3923|||3924|||3925|||3926|||3927|||3928|||3929|||3930|||3931|||3932|||3933|||3934|||3935|||3936|||3937|||3938|||3939|||3940|||3941	YSA*G	2.7% inhibition at 10000000-6000000 uM||2.0% inhibition at 10000000-5000000 uM||18.8% inhibition at 10000000-4000000 uM||26.7% inhibition at 10000000-3000000 uM||9.8% inhibition at 10000000-6000000 uM||7.3% inhibition at 10000000-5000000 uM||9.9% inhibition at 10000000-4000000 uM||28.2% inhibition at 10000000-3000000 uM||1.6% inhibition at 10000000-6000000 uM||2.9% inhibition at 10000000-5000000 uM||5.9% inhibition at 10000000-4000000 uM||17.9% inhibition at 10000000-3000000 uM||5.4% inhibition at 10000000-6000000 uM||7.4% inhibition at 10000000-5000000 uM||9.5% inhibition at 10000000-4000000 uM||15.7% inhibition at 10000000-3000000 uM||13.6% inhibition at 10000000-6000000 uM||20.4% inhibition at 10000000-5000000 uM||14.4% inhibition at 10000000-4000000 uM||23.4% inhibition at 10000000-3000000 uM||2.2% inhibition at 10000000-6000000 uM||4.2% inhibition at 10000000-5000000 uM||6.4% inhibition at 10000000-4000000 uM||6.2% inhibition at 10000000-3000000 uM||21.2% inhibition at 10000000-3000000 uM	N/A	N/A	N/A	N/A	4	L
FPDB00875	3942|||3943|||3944|||3945|||3946|||3947|||3948|||3949|||3950|||3951|||3952|||3953|||3954|||3955|||3956|||3957|||3958|||3959|||3960|||3961|||3962|||3963|||3964|||3965	YRA*G	4.6% inhibition at 10000000-6000000 uM||4.9% inhibition at 10000000-5000000 uM||12.6% inhibition at 10000000-4000000 uM||26.4% inhibition at 10000000-3000000 uM||11.0% inhibition at 10000000-6000000 uM||11.7% inhibition at 10000000-5000000 uM||11.6% inhibition at 10000000-4000000 uM||28.2% inhibition at 10000000-3000000 uM||1.2% inhibition at 10000000-5000000 uM||3.3% inhibition at 10000000-4000000 uM||19.4% inhibition at 10000000-3000000 uM||7.6% inhibition at 10000000-6000000 uM||3.8% inhibition at 10000000-5000000 uM||12.4% inhibition at 10000000-4000000 uM||22.4% inhibition at 10000000-3000000 uM||17.0% inhibition at 10000000-6000000 uM||13.5% inhibition at 10000000-5000000 uM||13.5% inhibition at 10000000-4000000 uM||25.3% inhibition at 10000000-3000000 uM||8.1% inhibition at 10000000-6000000 uM||6.9% inhibition at 10000000-5000000 uM||8.1% inhibition at 10000000-4000000 uM||8.6% inhibition at 10000000-3000000 uM||15.6% inhibition at 10000000-3000000 uM	N/A	N/A	N/A	N/A	4	L
FPDB00876	3966|||3967|||3968|||3969|||3970|||3971|||3972|||3973|||3974|||3975|||3976|||3977|||3978|||3979|||3980|||3981|||3982|||3983|||3984|||3985|||3986|||3987|||3988|||3989|||3990|||3991|||3992|||3993|||3994|||3995|||3996|||3997|||3998|||3999|||4000|||4001|||4002|||4003|||4004|||4005|||4006|||4007|||4008|||4009|||4010|||4011|||4012|||4013|||4014|||4015|||4016	YA*GFM	1.0% inhibition at 10000000-6000000 uM||10.1% inhibition at 10000000-5000000 uM||16.8% inhibition at 10000000-4000000 uM||36.1% inhibition at 10000000-3000000 uM||4.9% inhibition at 10000000-6000000 uM||10.2% inhibition at 10000000-5000000 uM||13.3% inhibition at 10000000-4000000 uM||28.0% inhibition at 10000000-3000000 uM||0.8% inhibition at 10000000-6000000 uM||1.4% inhibition at 10000000-5000000 uM||2.4% inhibition at 10000000-4000000 uM||18.3% inhibition at 10000000-3000000 uM||3.3% inhibition at 10000000-6000000 uM||11.0% inhibition at 10000000-5000000 uM||7.9% inhibition at 10000000-4000000 uM||23.7% inhibition at 10000000-3000000 uM||12.2% inhibition at 10000000-6000000 uM||15.5% inhibition at 10000000-5000000 uM||24.7% inhibition at 10000000-4000000 uM||29.0% inhibition at 10000000-3000000 uM||3.0% inhibition at 10000000-6000000 uM||8.4% inhibition at 10000000-5000000 uM||18.5% inhibition at 10000000-4000000 uM||10.6% inhibition at 10000000-3000000 uM||22.8% inhibition at 10000000-3000000 uM||13.7% inhibition at 10000000-6000000 uM||25.8% inhibition at 10000000-5000000 uM||34.7% inhibition at 10000000-4000000 uM||44.5% inhibition at 10000000-3000000 uM||8.5% inhibition at 10000000-6000000 uM||9.5% inhibition at 10000000-5000000 uM||15.4% inhibition at 10000000-4000000 uM||24.1% inhibition at 10000000-3000000 uM||2.4% inhibition at 10000000-6000000 uM||4.5% inhibition at 10000000-5000000 uM||11.4% inhibition at 10000000-4000000 uM||23.2% inhibition at 10000000-3000000 uM||16.2% inhibition at 10000000-6000000 uM||6.6% inhibition at 10000000-5000000 uM||5.1% inhibition at 10000000-4000000 uM||14.5% inhibition at 10000000-3000000 uM||26.4% inhibition at 10000000-6000000 uM||13.1% inhibition at 10000000-5000000 uM||14.6% inhibition at 10000000-4000000 uM||38.4% inhibition at 10000000-3000000 uM||17.7% inhibition at 10000000-6000000 uM||10.9% inhibition at 10000000-5000000 uM||12.1% inhibition at 10000000-4000000 uM||8.1% inhibition at 10000000-3000000 uM||9.6% inhibition at 10000000-4000000 uM||29.9% inhibition at 10000000-3000000 uM	N/A	N/A	N/A	N/A	5	L
FPDB00877	4017|||4018|||4019|||4020|||4021|||4022|||4023|||4024|||4025|||4026|||4027|||4028|||4029	YGGFMA*	3.9% inhibition at 10000000-5000000 uM||45% inhibition at 10000000-3000000 uM||9.3% inhibition at 10000000-3000000 uM||4.1% inhibition at 10000000-6000000 uM||70.7% inhibition at 10000000-5000000 uM||34.4% inhibition at 10000000-3000000 uM||9.2% inhibition at 10000000-3000000 uM||11.08% inhibition at 10000000-5000000 uM||47.0% inhibition at 10000000-3000000 uM||2.2% inhibition at 10000000-6000000 uM||7.1% inhibition at 10000000-5000000 uM||6.9% inhibition at 10000000-4000000 uM||25.9% inhibition at 10000000-3000000 uM	N/A	N/A	N/A	N/A	6	L
FPDB00878	4208|||4209|||4210	Aoc-Hse-E-Dhb-Hyp-Hse-FLIILG	No inhibition at 4 uM	N/A	N/A	N/A	N/A	22	L
FPDB00879	4211|||4212|||4213|||4214|||4215|||4216|||4217	A-Hleu-QN-MeIle-Hasn-TPLT-Ade-V-Hleu	50% inhibition at 1 uM||44% inhibition at 1 uM||40% inhibition at 1 uM	N/A	N/A	N/A	N/A	28	L
FPDB00880	4618|||4619|||DRAMP03913	KWKWKW	at 10 uM 60% viablity||at 10 uM 35-40% viablity||Antimicrobial||Antifungal	Synthetic construct (De novo design)	N/A	N/A	Int J Mol Sci. 2012; 13(11): 15042-15053.	6	L
FPDB00881	5015	KAQ-Dip-QKQAW	IC50= >350 uM	N/A	N/A	N/A	N/A	11	L
FPDB00882	3165.0|||3166.0|||3167.0|||3168.0|||3169.0|||3170.0|||3171.0|||3172.0|||3173.0|||3174.0|||3175.0|||3176.0|||3177.0|||3178.0|||3179.0|||3180.0|||3181.0|||3182.0|||3183.0|||3184.0|||3185.0|||3186.0|||3187.0|||3188.0	fCYwO-CyLeu-Pen-TKKrPKPfQwFwL-CyLeu-KKLMYPTYLKKfQWAV-Aib-HL	10.6 % inhibition of cell proliferation at 0.001 uM||18.2 % inhibition of cell proliferation at 0.01 uM||30.7 % inhibition of cell proliferation at 0.1 uM||43.1 % inhibition of cell proliferation at 1 uM||98.3 % inhibition of cell proliferation at 10 uM||24.2 % inhibition of cell proliferation at 0.001 uM||37.8 % inhibition of cell proliferation at 0.01 uM||48.2 % inhibition of cell proliferation at 0.1 uM||59.6 % inhibition of cell proliferation at 1 uM||84.5 % inhibition of cell proliferation at 10 uM||16.5 % inhibition of cell proliferation at 0.001 uM||14.2 % inhibition of cell proliferation at 0.01 uM||16.8 % inhibition of cell proliferation at 0.1 uM||21.7 % inhibition of cell proliferation at 1 uM||27.9 % inhibition of cell proliferation at 10 uM||10.4 % inhibition of cell proliferation at 0.001 uM||18.7 % inhibition of cell proliferation at 0.01 uM||34.7 % inhibition of cell proliferation at 0.1 uM||54.3 % inhibition of cell proliferation at 1 uM||94.5 % inhibition of cell proliferation at 10 uM||activity value is ED50 = 2.1 uM||activity value is ED50 = 0.21 uM||activity value is ED50 > 10 uM||activity value is ED50 = 0.29 uM	N/A	N/A	N/A	N/A	52	Mix
FPDB00883	3720.0|||3721.0|||3722.0|||3723.0|||3724.0|||3725.0	fA*YwKA*T	activity value is IC50 = 17.05||activity value is IC50 = 16.93||activity value is IC50 = 33.88||activity value is IC50 = 27.69||activity value is IC50 = 29.97||activity value is IC50 = 36.81	N/A	N/A	N/A	N/A	7	Mix