Unique_ID Origin_ID Sequence Activity Source Structure Hemolysis Reference Length Stereo FPDB00001 AP00001|||2846|||2847|||2848|||2849|||2850|||AP00001|||Adenoregulin|||DRAMP01646|||Adenoregulin|||AP00001|||DRAMP01646 GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV Anti-M. canis IP 1194, activity value is MIC = 10 ug/ml||Anti-T. rubrum IP 1400-82, activity value is MIC = 15 ug/ml||Anti-A. fumigatus IP 1025-70, activity value is MIC = 125 ug/ml||Anti-A. simii IP 1063-74, activity value is MIC = 30 ug/ml||Anti-A. caviae IP 67-16 T, activity value is MIC = 60 ug/ml||Anti-E. coli IP 76-24, activity value is MIC = 15 ug/ml||Anti-P. aeruginosa, activity value is MIC = 3.1 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 0.7 uM||Anti-N. brasiliensis IP 16-80, activity value is MIC = 30 ug/ml||Anti-C. neoformans IP 960-67 or IP 962-67, activity value is MIC = 15 ug/ml||Anti-and C. albicans, activity value is MIC = 15 ug/ml||activity value is GI50 = 1.24||activity value is GI50 = 0.31||activity value is GI50 = 0.91||activity value is GI50 = 8.06||activity value is GI50 = 2.57||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anticancer||Antibacterial||Anti-Microsporum canis, activity value is MIC = 10 ug/ml||Anti-Tricophyton rubrum, activity value is MIC = 15 ug/ml||Anti-Arthroderma simii, activity value is MIC = 30 ug/ml||Anti-Aspergillus fumigatus IP, activity value is MIC = 125 ug/ml||Anti-Aerornonas caviae, activity value is MIC = 60 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 15 ug/ml||Anti-Candida albicans, activity value is MIC = 15 ug/ml||Anti-Escherichia coli, activity value is MIC = 15 ug/ml||Anti-Nocardia brasiliensis, activity value is MIC = 30 ug/ml||Anti-usporum canis IP 11 94, activity value is MIC = 10 ug/ml||Anti-Tricophyton rubrum IP 1400-82, activity value is MIC = 15 ug/ml||Anti-Arthroderma simii IP 1063-74, activity value is MIC = 30 ug/ml||Anti-Aspergillus fumigatus IP 1025-70, activity value is MIC = 125 ug/ml||Anti-Aerornonas caviae IP 67-16 T, activity value is MIC = 60 ug/ml||Anti-Escherichia coli IP 76-24, activity value is MIC = 15 ug/ml||Anti-Nocardia brasiliensis IP 16-80, activity value is MIC = 30 ug/ml||Anti-Cryptococcus neoformans IP 960-67, activity value is MIC = 15 ug/ml||Anti-Cryptococcus neofonnans IP 962-67, activity value is MIC = 15 ug/ml||Anti-Candida albicans IP 884-65, activity value is MIC = 15 ug/ml skin, the arboreal frog, Giant leaf frog, Phyllomedusa bicolor, South America|||skin, the arboreal frog, Giant leaf frog, Phyllomedusa bicolor, South America|||Phyllomedusa bicolor [Two-colored leaf frog]|||Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)|||Phyllomedusa bicolor [Two-colored leaf frog]|||skin, the arboreal frog, Giant leaf frog, Phyllomedusa bicolor, South America|||Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) Helix||Alpha helix In Document 1 (Eur. J. Biochem. 1994), various peptides of the dermaseptin family (including DS I, DS II-V, and adenoregulin/DS bII) showed no significant hemolytic activity. When tested on rabbit red blood cells, no hemolysis was observed even at the highest test concentration of 250 µg/ml.|||[Ref:8306981]Lack hemolytic activity against rabbit red blood cells|||No hemolytic activity (0% hemolysis at 200 μM)|||[Ref:8306981]Lack hemolytic activity against rabbit red blood cells "Biochem Biophys Res Commun. 1993 Mar 31;191(3):983-90. doi: 10.1006/bbrc.1993.1314. PubMed.|||Amiche M, Ducancel F, Lajeunesse E, Boulain JC, Ménez A, Nicolas P. 1993 Biochem Biophys Res Commun. 1993 Mar 31;191(3):983-90. doi: 10.1006/bbrc.1993.1314. PubMed.|||Comparative Study Biochem Biophys Res Commun . 1993 Mar 31;191(3):983-90. doi: 10.1006/bbrc.1993.1314.|||8306981|||Eur J Biochem 1994, 219 (1-2):145-154.||Ref.8306981|||8306981||Ref.8306981|||8306981|||Biochem Biophys Res Commun. 1993 Mar 31;191(3):983-90. doi: 10.1006/bbrc.1993.1314.|||Ref.8306981|||Biochem Biophys Res Commun. 1993 Mar 31;191(3):983-90. doi: 10.1006/bbrc.1993.1314. PubMed." 33 L FPDB00002 AP00026|||AP00026|||Lactotransferrin precursor|||LFcinB|||DRAMP02840 FKCRRWQWRMKKLGAPSITCVRRAF Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||anti-sepsis||Synergistic AMPs||Anticancer||Anti-E. coli IID-861, activity value is MIC = 2 uM||Anti-K. pneumoniae JCM1662T, activity value is MIC = 3 uM||Anti-P. aeruginosa IFO-3446, activity value is MIC = 3 uM||Anti-S. aureus JCM-2151 or MRSA, activity value is MIC = 2 uM||Anti-L. monocytogenes IDF-1 b, activity value is MIC = 0.3 uM||MRSA||Antibacterial||Anti-Streptomyces scabiei S58, activity value is IC50 = 1.222||Anti-Escherichia coli L361, activity value is MIC = 4 uM||Anti-Salmonella Salford, activity value is MIC = 4 uM||Anti-Escherichia coli O:9, activity value is MIC = 6 uM||Anti-Pseudomonas fluorescens, activity value is MIC = 10 uM||Anti-Listeria monocytogenes, activity value is MIC = 2 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Bacillus cereus, activity value is MIC = 6 uM||Anti-ctive against E. coli IID-861, activity value is MIC = 2 uM cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine) Beta||Beta strand (4 strands; 8 residues) E.coli ( MIC = 12.5 ug/ml) "J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.|||Bellamy W, Takase M, Wakabayashi H, Kawase K, Tomita M.1992 J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol. 1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.|||1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol . 1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.|||9521752 , 8980754|||35213576|||Ref.8980754|||1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012" 25 FPDB00004 AP00058|||1649|||1653|||1657|||1661|||AP00058|||Maximin 1|||DRAMP01107|||Maximin 1|||AP00058|||AP00058|||DRAMP01107|||Maximin 1 GIGTKILGGVKTALKGALKELASTYAN Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Spermicidal||Anti-HIV||Hemolytic||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 19.5 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 19.5 ug/ml||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 19.5 ug/ml||Anti-B. megatherium, activity value is MIC = 19.5 ug/ml||Anti-K. pneumoniae, activity value is MIC = 9 ug/ml||Anti-B. dysenterium, activity value is MIC = 2.7 uM||Anti-C. albicans ATCC2002, activity value is MIC = 3 uM||activity value is IC50 = 15.3 ug/ml||activity value is IC50 = 24.3 ug/ml||activity value is IC50 = 20.5 ug/ml||activity value is IC50 = 35.4 ug/ml||Anti-Escherichia coli ATCC25922, activity value is MIC = 9 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 4.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 9 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 4.5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 19.5 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 9 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 19.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 19.5 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 19.5 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 2.7 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima Helix "No hemolytic activity (0% hemolysis at 100 µM)|||In Document 3 (Eur. J. Immunol. 2005), the specific hemolytic values of the maximin family and maximin H family antimicrobial peptides in the skin secretions of the large-webbed bell toad (Bombina maxima) are not explicitly mentioned.|||No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml. Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells" "Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002. Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides . 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed." 27 L FPDB00005 AP00060|||1650|||1654|||1658|||1662|||AP00060|||Maximin 3|||DRAMP01109|||Maximin 3|||AP00060|||DRAMP01109|||AP00060|||DRAMP01109|||Maximin 3 GIGGKILSGLKTALKGAAKELASTYLH Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Spermicidal||Anti-HIV||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 0.9 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 3.1 ug/ml||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 1.5 ug/ml||Anti-B. megatherium, activity value is MIC = 0.9 ug/ml||Anti-B. dysenterium, activity value is MIC = 0.9 ug/ml||Anti-K. pneumoniae, activity value is MIC = 3.1 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 15 uM||activity value is IC50 = 11.4 ug/ml||activity value is IC50 = 25.2 ug/ml||activity value is IC50 = 28 ug/ml||activity value is IC50 = 18 ug/ml||Anti-and T24, activity value is IC50 = 11||Anti-Escherichia coli ATCC25922, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 2 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 4 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 0.9 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 3.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 1.5 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 0.9 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 0.9 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 15 ug/ml||Anti-HIV-1, activity value is IC50 = 11.4 ug/ml||activity value is EC50 = 1.5 ug/ml||Anti-Cancer cell lines: C8166, activity value is IC50 = 11.4 ug/ml||Anti-Molt-4, activity value is IC50 = 25.2 ug/ml||Anti-BIU-87, activity value is IC50 = 28 ug/ml||Anti-T24, activity value is IC50 = 18 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima Helix "No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml. Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells|||human RBC: HC50 >250 ug/ml, less hemo.lytic. toxic to cell IC50 11.4 ug/ml, anti-HIV-1 EC50 1.5 ug/ml, cell selectivity index 7.6 (Lai R et al., 2012)." "Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002. Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides . 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed." 27 L FPDB00006 AP00061|||AP00061|||Maximin 4|||DRAMP01110|||Maximin 4|||AP00061|||DRAMP01110|||AP00061|||DRAMP01110|||Maximin 4 GIGGVLLSAGKAALKGLAKVLAEKYAN Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Spermicidal||Anti-HIV||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 2.7 uM||Anti-S. aureus ATCC2592, activity value is MIC = 2.7 uM||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 2.7 uM||Anti-B. megatherium, activity value is MIC = 1.5 uM||Anti-B. dysenterium, activity value is MIC = 2.7 uM||Anti-K. pneumoniae, activity value is MIC = 15 uM||Anti-C. albicans ATCC2002, activity value is MIC = 15 uM||Anti-and P.uticale IFFI2001 . active against cancer cells C8166 and Molt-4, activity value is IC50 = 24||Anti-Escherichia coli ATCC25922, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 10 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 20 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.7 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 15 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 2.7 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 2.7 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 1.5 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 2.7 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 15 ug/ml||Anti-HIV-1, activity value is IC50 = 24.2 ug/ml||activity value is EC50 = 21.9 ug/ml||Anti-Cancer cell lines: C8166, activity value is IC50 = 24.2 ug/ml||Anti-Molt-4, activity value is IC50 = 35.4 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima Helix "No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml. Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells|||toxic to cell IC50 24.2 ug/ml, similar to EC50 against HIV-1 (Lai R et al., 2012)." "Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002. Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides . 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9. Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed." 27 FPDB00007 AP00062|||1652|||1656|||1660|||1664|||AP00062|||Maximin 5|||DRAMP01111|||Maximin 5|||AP00062|||DRAMP01111|||AP00062|||DRAMP01111|||Maximin 5 SIGAKILGGVKTFFKGALKELASTYLQ Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anticancer||Anti-S. aureus ATCC2592, activity value is MIC = 3.6 uM||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 7.2 uM||Anti-B. megatherium, activity value is MIC = 12 uM||Anti-B. dysenterium, activity value is MIC = 12 uM||Anti-K. pneumoniae, activity value is MIC = 3.6 uM||Anti-C. albicans ATCC2002, activity value is MIC = 1.2 uM||Anti-A. flavus IFFI4015, activity value is MIC = 12 ug/ml||Anti-and P. uticale IFFI2001, activity value is MIC = 12 ug/ml||activity value is IC50 = 34.4 ug/ml||activity value is IC50 > 50 ug/ml||IC50 =>50 ug/ml||IC50=>50 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 3.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB10104, activity value is MIC = 7.2 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 12 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 12 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 3.6 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 1.2 ug/ml||Anti-Aspergillus flavus IFFI4015, activity value is MIC = 12 ug/ml||Anti-Penicillium uticale IFFI2001, activity value is MIC = 12 ug/ml||Anti-HIV-1, activity value is MIC = 34.4 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 3.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 7.2 ug/ml||Anti-Aspergillus flavus IFFI 4015, activity value is MIC = 12 ug/ml||Anti-Penicillium uticale IFFI 2001, activity value is MIC = 12 ug/ml||Anti-HIV-1, activity value is IC50 = 34.4 ug/ml||activity value is EC50 = 39.8 ug/ml||Anti-Cancer cell lines: C8166, activity value is IC50 = 34.4 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima N/A "No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml. Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells|||IC50 34.4 ug/ml, against HIV-1 cell selectivity index 0.88 (Lai R et al., 2012). Updated 2/2012; 12/2015; 11/2024 GW." "Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002. Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides . 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed." 27 L FPDB00008 AP00121|||DRAMP30312|||AP00121|||DRAMP30312 GLMDTVKNVAKNLAGHMLDKLKCKITGC "Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-S. aureus, activity value is MIC = 50 uM||Anti-E. coli, activity value is MIC = 13 uM||Anti-and C. albicans, activity value is MIC = 67 uM||Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(90% inhibition at 500 uM); Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(99% inhibition at 50 uM)." North American frog, Rana pipiens , or Lithobates pipiens, ALSO: the Oregon spotted frog Rana pretiosa|||Rana pipiens (Northern leopard frog)|||North American frog, Rana pipiens , or Lithobates pipiens, ALSO: the Oregon spotted frog Rana pretiosa|||Rana pipiens (Northern leopard frog) N/A N/A "Eur J Biochem. 2000 Feb;267(3):894-900. PubMed|||Eur J Biochem. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Comparative Study Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Ref.11601906|||2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Virology. 2001 Sep 30;288(2):351-7.||Ref.11601906|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed." 28 FPDB00010 AP00146|||1841|||1993|||2145|||2297|||2450|||2593|||2736|||3337|||3338|||3339|||3340|||3791|||3797|||3803|||3809|||3815|||AP00146|||Melittin|||DRAMP03002|||AP00146|||Melittin GIGAVLKVLTTGLPALISWIKRKRQQ Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Insecticidal||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Anti-E. coli W 160-37, activity value is MIC = 5||Anti-S. aureus 8530B, activity value is MIC = 10||Anti-B. subtilis, activity value is MIC = 2||Anti-and P. putida NCIM 2102, activity value is MIC = 25||Anti-and E. agglomerans Bo-1S . ActivityG: D=L. Also active against colistin-resistant A. baumannii. C. albicans, activity value is MIC = 3||Anti-HSV-2 . It is also insecticidal, activity value is EC50 = 5.9||Anti-S. aureus, activity value is MIC = 4.4 uM||Anti-and E. faecium, activity value is MIC = 2.2 uM||Anti-P. aeruginosa, activity value is MIC = 2.2 uM||Anti-and V. vulnificus, activity value is MIC = 4.4 uM||Anti-T. beigelii, activity value is MIC = 4.4 uM||Anti-M. furfur, activity value is MIC = 8.8 uM||activity value is LD50 = 9 ug/ml||activity value is LD50 = 23 ug/ml||activity value is LD50 = 18 ug/ml||activity value is LD50 = 25 ug/ml||activity value is LD50 = 13 ug/ml||activity value is LD50 = 35 ug/ml||activity value is IC50 = 3.2||activity value is IC50 = 2.1||activity value is IC50 = 1.8||activity value is IC50 = 1.4||Anti-and E. agglomerans Bo-1S . ActivityG: D=L. Also active against colistin-resistant A. baumannii. Active against Gram+ bacteria S. mutants, activity value is MIC = 1.1 uM||Anti-S. aureus 29213 or 25923, activity value is MIC = 2 uM||Anti-L.rhamnosus 1.0385 or 1.0911, activity value is MIC > 128 uM||Anti-L.plantarum 7469, activity value is MIC > 128 uM||Anti-S.thermophilus YM-C, activity value is MIC > 128 uM||Anti-C. tropicalis cgmcc 2.1975, activity value is MIC = 2 uM||Anti-and C. parapsilosis cgmcc 2.3989, activity value is MIC = 2 uM||Anti-SARS CoV2, activity value is EC50 = 0.656 ug||Anti-E. coli 25922, activity value is MIC = 1 uM||Anti-E. coli UB1005, activity value is MIC = 1 uM||Anti-E. coli K88, activity value is MIC = 1 uM||Anti-E. coli K99, activity value is MIC = 1 uM||Anti-E. coli 078, activity value is MIC = 2 uM||Anti-E. coli 987P, activity value is MIC = 1 uM||Anti-P. aeruginosa 27853, activity value is MIC = 2 uM||Anti-P. aeruginosa PAO1, activity value is MIC = 2 uM||Anti-S. typhimurium 14028, activity value is MIC = 2 uM||Anti-S. typhimurium 7731, activity value is MIC = 2 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 2 uM||Anti-Listeria monocytogenes CMCC 54004, activity value is MIC = 1 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 uM||Anti-Escherichia coli UB 1005, activity value is MIC = 2 uM||Anti-Salmonella pullorum C7913, activity value is MIC = 8 uM||Anti-Salmonella enterica subsp enterica CMCC 50071, activity value is MIC = 2 uM||Enzyme inhibitor Honeybee venom, Apis mellifera (also A. florea, A. cerana)|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Honeybee venom, Apis mellifera (also A. florea, A. cerana)|||Apis mellifera [Honeybee]|||Apis mellifera (Honeybee)|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Apis mellifera [Honeybee] Helix||Alpha helix "Since these amphiphilic peptides may be membrane dis ruptive (12), magainin 2 was assayed for hemolytic activityagainst human erythrocytes (Fig. 4B). Unlike mellitin, ahemolytic, amphiphilic 26-amino acid peptide from beevenom (12), magainin 2 was not hemolytic up to at least 0.00015 ug/ml in phosphate-buffered normal saline (Fig. 4B). Theabsence of hemolytic activity of magainin 2 is striking in thatit possesses a potential hydrophobic moment very similar tomellitin (12)|||Moderate hemolytic activity (50% hemolysis at 50 µM)|||Under physiological salt concentration, when melittin at concentrations up to 500 µg was incubated with 1×10⁹/ml human red blood cells at 37°C for 3 hours, no significant hemolytic activity was observed (<0.5%); however, in 10,000 µM sodium phosphate buffer containing 340,000 µM sucrose, high concentrations of melittin exhibited significant hemolytic activity, although the exact values were not specified.|||​|||sheep red blood cells (11000 uM)|||In Document 11 (Gene 2018), the recombinant hybrid antimicrobial peptide AL32-P113 and the synthetic hybrid peptide L31-P113 both exhibited hemolytic activity against human erythrocytes. At a concentration of 500 μg/ml, the hemolysis rate of AL32-P113 was 10.4% ± 2.2%, and that of L31-P113 was 12.0% ± 0.7%; as controls, the hemolysis rate of LL-37 was 2.9% ± 0.7%, and that of Hst-5 was 1.6% ± 0.6%.|||Moderate hemolytic activity (50% hemolysis at 50 µM)|||sheep red blood cells (11000 uM)|||It is highly hemolytic (100% at 6.25 uM) and can cause histamine release (85% at 10 uM) (Kawakami et al., 2017)." "Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med.|||Fennell JF, Shipman WH, Cole LJ.1967 Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med.||ref AP252||Ref. AP83||ref, see AP2411||see ref. AP1480||Yasin et al., 2000||Perez-Cordero JJ et al. 2011 Peptides 32, 683-90|||Res Dev Tech Rep. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638|||. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638||Yasin et al., 2000|||Res Dev Tech Rep . 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||ref, see AP2411||see ref. AP1480||Yasin et al., 2000||Perez-Cordero JJ et al. 2011 Peptides 32, 683-90|||9568968, 35236909|||31199117|||Eur J Biochem. 1983 Sep 1;135(1):123-126.||Ref.29783753|||Res Dev Tech Rep. 1967 Dec 5:1-13.doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638|||9568968, 35236909|||Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med." 26 L FPDB00012 AP00157|||1708|||AP00157|||Dermaseptin-1|||DRAMP01668|||Dermaseptin-1|||AP00157|||DRAMP01668 ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||Anti-A. caviae IP67-16T, activity value is MIC = 0.5 uM||Anti-E. coli IP76-24, activity value is MIC = 1 uM||Anti-S. aureus IP76-25, activity value is MIC = 5 uM||Anti-N. brasiliensis IP118079, activity value is MIC = 35 uM||Anti-S. cerevisiae IP118079, activity value is MIC = 5 uM||Anti-IP886-65, activity value is MIC = 10 uM||Anti-C. neoformans IP960-67 and IP962-67, activity value is MIC = 0.5||Anti-M. canis IP1194, activity value is MIC = 15 uM||Anti-T. rubrum IP2043-92, activity value is MIC = 35 uM||Anti-T. metagrophytes IP877-71, activity value is MIC = 20 uM||Anti-mutant, activity value is MIC = 30 uM||Anti-A. simii J43, activity value is MIC = 15 uM||Anti-A. niger IP218-53 and A. fumigatus IP1025-70, activity value is MIC = 30 uM||Antibacterial||Anti-Microsporum canis, activity value is MIC = 50 ug/ml||Anti-Tricophyton rubrum, activity value is MIC = 100 ug/ml||Anti-Arthroderma simii, activity value is MIC = 100 ug/ml||Anti-Aspergillus fumigatus, activity value is MIC = 100 ug/ml||Anti-Aerornonas caviae IP T, activity value is MIC = 50 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 15 ug/ml||Anti-Candida albicans, activity value is MIC = 60 ug/ml||Anti-Escherichia coli, activity value is MIC = 5 ug/ml||Anti-Nocardia brasiliensis, activity value is MIC = 200 ug/ml||Anti-usporum canis IP 11 94, activity value is MIC = 50 ug/ml||Anti-Tricophyton rubrum IP 1400-82, activity value is MIC = 100 ug/ml||Anti-Arthroderma simii IP 1063-74, activity value is MIC = 100 ug/ml||Anti-Aspergillus fumigatus IP 1025-70, activity value is MIC = 100 ug/ml||Anti-Aerornonas caviae IP 67-16 T, activity value is MIC = 50 ug/ml||Anti-Escherichia coli IP 76-24, activity value is MIC = 5 ug/ml||Anti-Nocardia brasiliensis IP 16-80, activity value is MIC = 200 ug/ml||Anti-Cryptococcus neoformans IP 960-67, activity value is MIC = 15 ug/ml||Anti-Cryptococcus neofonnans IP 962-67, activity value is MIC = 15 ug/ml||Anti-Candida albicans IP 884-65, activity value is MIC = 60 ug/ml Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagii [Sauvage leaf frog]|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Phyllomedusa sauvagii [Sauvage leaf frog]|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog) Helix||Alpha helix (CD) No hemolytic activity (0% hemolysis at 200 μM)|||When incubated with rabbit red blood cells at 1000 µg/ml of dermaseptin for 20 minutes, 100% hemolysis was observed; however, no hemolysis was detected after 2 hours of incubation at a concentration of 200 µg/ml, and within the concentration range of 0.8–1000 µg/ml, there was no significant effect on normal clotting time (120 seconds).|||Dermaseptin in (Biochemistry 1991), at a concentration of 1000 µg/ml for 20 minutes, can cause 100% hemolysis, but at a concentration of 200 µg/ml for 2 hours, it has no hemolytic effect on rabbit red blood cells.|||No hemolytic activity (0% hemolysis at 200 μM) "Biochemistry. 1991;30(36):8824-8830. doi:10.1021/bi00100a014.PubMed.|||Biochemistry. 1991;30(36):8824-8830. doi:10.1021/bi00100a014.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90|||J Biol Chem . 1994 Dec 16;269(50):31635-41.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90|||9614066 , 1909573|||Biochemistry. 1991 Sep 10;30(36):8824-8830.|||1909573|||9614066 , 1909573|||Biochemistry. 1991;30(36):8824-8830. doi:10.1021/bi00100a014.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90|||1994 Dec 16;269(50):31635-41.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90" 34 L FPDB00013 AP00160|||AP00160|||DS4|||DRAMP18708|||AP00160|||DRAMP18708 ALWMTLLKKVLKAAAKAALNAVLVGANA Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||anti-sepsis||Antimalarial||Hemolytic||Anti-A. caviae IP67-16T, activity value is MIC = 0.5 uM||Anti-E. coli IP76-24, activity value is MIC = 4 uM||Anti-S. aureus IP76-25, activity value is MIC = 10||Anti-N. brasiliensis IP118079, activity value is MIC = 10 uM||Anti-S. cerevisiae IP118079, activity value is MIC = 20 uM||Anti-IP886-65, activity value is MIC = 20 uM||Anti-C. neoformans IP960-67 and IP962-67, activity value is MIC = 1||Anti-M. canis IP1194, activity value is MIC = 15 uM||Anti-T. rubrum IP2043-92, activity value is MIC = 40 uM||Anti-T. metagrophytes IP877-71, activity value is MIC = 20 uM||Anti-mutant, activity value is MIC = 30 uM||Anti-A. simii J43, activity value is MIC = 20 uM||Anti-A. niger IP218-53 and A. fumigatus IP1025-70, activity value is MIC = 20||Anti-C. albicans, activity value is MIC = 11.5||Anti-S1, activity value is MIC = 295.97 ug/ml||Anti-S2, activity value is MIC = 380.82 ug/ml||Anti-S3, activity value is MIC = 343.68 ug/ml||Anti-S4, activity value is MIC = 358.13 ug/ml||Anti-S5, activity value is MIC = 274.17 ug/ml||Anti-S6, activity value is MIC = 330.65 ug/ml||Anti-S7, activity value is MIC = 411.06 ug/ml||Anti-S1, activity value is MIC = 250.22 ug/ml||Anti-S2, activity value is MIC = 269.06 ug/ml||Anti-S3, activity value is MIC = 490.77 ug/ml||Anti-S4, activity value is MIC = 257.4 ug/ml||Anti-S5, activity value is MIC = 308.89 ug/ml||Anti-S6, activity value is MIC = 344.32 ug/ml||Anti-S7, activity value is MIC = 275.73 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||[Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria||fungi||protozoa||and the enveloped herpes simplex virus type 1 Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa hypochondrialis [orange-legged leaf frog]|||Synthetic construct|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog) Helix||Alpha helix No hemolytic activity (0% hemolysis at 200 μM)|||Dermaseptin S1: At a concentration of 70 µM, treatment for 1 hour did not cause hemolysis of human red blood cells. Dermaseptin S2: At 70 µM, hemolysis of red blood cells occurred within 1 hour. Dermaseptin S3: At 80 µM, hemolysis of red blood cells occurred within 1 hour. Dermaseptin S4: At 1 µM, 100% hemolysis occurred within 1 hour; at 0.5 µM, 50% hemolysis was observed. Dermaseptin S5: At a concentration of 90 µM, treatment for 1 hour did not cause hemolysis of human red blood cells.|||hRBCs, >50% hemolysis at 8 ug/ml|||hRBCs, >50% hemolysis at 128 ug/ml|||[Swiss_Prot Entry P80280]Strong hemolytic activity "J Biol Chem. 1994;269(50):31635-31641.PubMed.|||J Biol Chem. 1994;269(50):31635-31641.|||1994 Dec 16;269(50):31635-41.|||J Biol Chem . 1994 Dec 16;269(50):31635-41.|||33774792|||Eur. J. Biochem. 1994; 219:145-154.|||J Biol Chem. 1994;269(50):31635-31641.|||Eur. J. Biochem. 1994; 219:145-154." 28 FPDB00017 AP00179|||DRAMP03594|||Neutrophil defensin 4|||AP00179|||DRAMP03594|||AP00179|||DRAMP03594 VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Active against E. coli||S. faecalis||and C. albicans.||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)||Antiviral(SARS-CoV-4) Homo sapiens|||Homo sapiens (Human)|||Homo sapiens [Human]|||Homo sapiens|||Homo sapiens (Human)|||Homo sapiens|||Homo sapiens (Human) Beta||Beta strand No hemolysis information or data found in the reference(s) presented in this entry "J. Biol. Chem. 1989; 264:11200-11203. PubMed.|||1989 Jul 5;264(19):11200-3.|||J. Biol. Chem. 1989; 264:11200-11203.|||Comparative Study J Biol Chem . 1989 Jul 5;264(19):11200-3.|||Viruses. 2021 Jun 26;13(7):1246.|||2500436, 17088326, 30658057|||J. Biol. Chem. 1989; 264:11200-11203.|||Viruses. 2021 Jun 26;13(7):1246.Protein Sci. 2006 Dec;15(12):2749-2760.FEBS Lett. 2005 Jan 3;579(1):162-166.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.|||1989 Jul 5;264(19):11200-3.|||Viruses. 2021 Jun 26;13(7):1246." 33 FPDB00018 AP00195|||1426|||AP00195|||IB-200|||IB-445|||OLAP-311|||Protegrin-1|||Recombinant Protegrin-1|||PG-1|||Protegrin|||IB-247 RGGRLCYCRRRFCVCVGR "Anti-Gram+||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||anti-sepsis||Synergistic AMPs||Hemolytic||Antibiofilm||61% Cytotoxicity at 0.5 ug/ml||Anti-E. coli 004, activity value is MIC = 0.12 ug/ml||Anti-V, activity value is MIC = 0.25 ug/ml||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 0.5 ug/ml||Anti-S. aureus ATCC 33591 or MRSA, activity value is MIC = 2 ug/ml||Anti-MRSA, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 2 ug/ml||MIC E.Coli (ATCC 25922: 2 ug/ml||ATCC 700926: 0.25 ug/ml||MB 4902: 0.015 ug/ml)||K. pneumoniae (ATCC 13883: 0.5 ug/ml||ATCC 700603: 4 ug/ml||BAA 2146: 4 ug/ml)||A. baumannii (ATCC 19606): 0.25 ug/ml||P. aeruginosa (ATCC 27853): 4 ug/ml||B. subtilis (ATCC 6051): 0.03 ug/ml||S. aureus ATCC 43300 (MRSA): 4 ug/ml||C. albicans (ATCC 90028): 2 ug/ml||C. neoformans (ATCC 208821): 0.06 ug/ml||Anti-E. coli, activity value is MIC = 64 ug/ml||Anti-S. aureus, activity value is MIC = 64 ug/ml||Anti-S. epiderrnidis, activity value is MIC = 2 ug/ml||Anti-Escherichia coli ATCC 25377, activity value is MIC = 3 ug/ml||Anti-A. baumannii ATCC 238719, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 361823, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 371484, activity value is MIC = 2 ug/ml||Anti-A. baumannii ATCC 371981, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 378177, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 378648, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 379385, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 379622, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 380023, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 380667, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 381577, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 382933, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 383074, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 383290, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 386052, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 388538, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 5615, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 12316, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 12834, activity value is MIC = 4 ug/ml||Anti-S. aureus 29213, activity value is MIC = 1.7 ug/ml||Anti-E. coli 25922, activity value is MIC = 0.75 ug/ml||Anti-P. aeruginosa 27853, activity value is MIC = 0.5 ug/ml||Anti-E. faecalis 29212, activity value is MIC = 2.7 ug/ml||Anti-""A. baumannii ATCC 238719, activity value is MIC = 4 ug/ml||Antibacterial||Anti-K. pneumoniae strains NTUH-K2044, activity value is MIC = 0.5 ug/ml||Anti-ATCC 43816, activity value is MIC = 0.5 ug/ml||Anti-ATCC 13883, activity value is MIC = 0.5 ug/ml||Anti-ATCC 700603, activity value is MIC = 0.5 ug/ml||Anti-MKP103, activity value is MIC = 2 ug/ml||Anti-MKP103 wza mutant, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 0.5 ug/ml" leukocytes; porcine neutrophil, pig, Sus scrofa|||eukocytes; porcine neutrophil, pig, Sus scrofa|||leukocytes; porcine neutrophil, pig, Sus scrofa|||Synthetic construct|||Porcine neutrophils|||Sus scrofa [pig] Beta 96.1% hemolysis at 64 uM (see ref. AP05000). Chem Pharm Bull (Tokyo). 1995 May;43(5):853-8|||Chem Pharm Bull (Tokyo). 1995 May;43(5):853-8||Blower et al., 2018||Yasin et al., 2000||Guo C et al., 2014||Sousa et al., 2017|||Blower et al., 2018||Yasin et al., 2000||Guo C et al., 2014||Sousa et al., 2017|||8647100|||31399625|||31214759|||28382709, 9257752, 31214759||Refer 31214759|||34502403|||35254120|||10931444 18 L FPDB00019 AP00211|||AP00211|||OLAP-313|||Polyphemusin-1|||L-Polyphemusin|||DRAMP02933|||Polyphemusin-1|||AP00211 RRWCFRVCYRGFCYRKCR Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||anti-sepsis||Anti-Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1 ug/ml||Anti-E. coli K12, activity value is MIC = 6.3 ug/ml||Anti-S. Minnesota 1114W or R595, activity value is MIC = 3.1||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 6.3 ug/ml||Anti-and C. albicans M9, activity value is MIC = 6.3 ug/ml||MIC E.Coli (ATCC 25922: 0.5 ug/ml||ATCC 700926: 0.06 ug/ml||MB 4902: 0.03 ug/ml)||K. pneumoniae (ATCC 13883: 0.5 ug/ml||ATCC 700603: 1 ug/ml||BAA 2146: 2 ug/ml)||A. baumannii (ATCC 19606): 0.06 ug/ml||P. aeruginosa (ATCC 27853): 2 ug/ml||B. subtilis (ATCC 6051): 0.25 ug/ml||S. aureus ATCC 43300 (MRSA): 2 ug/ml||C. albicans (ATCC 90028): 1 ug/ml||C. neoformans (ATCC 208821): 0.06 ug/ml||Antibacterial||Anti-S.aureus, activity value is MIC = 16 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 0.5 ug/ml||Anti-E. coli DC2, activity value is MIC = 1 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 0.25 ug/ml||Anti-S. typhimurium, activity value is MIC = 1 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-Staphylococcus aureus SAP0017, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 1 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 1 ug/ml||Antifungal ; Candida albicans M9||Anti-Active against Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1 ug/ml Limulus polyphemus|||Limulus polyphemus|||Limulus polyphemus [Atlantic horseshoe crab]|||Synthetic construct|||Limulus polyphemus (Atlantic horseshoe crab)|||Limulus polyphemus Beta||No secondary structure (CD) Moderate hemolytic activity (40% hemolysis at 20 μM)|||IC50 for hRBC = 1885 ug/ml "J. Biochem. 1989; 106: 663-668. PubMed|||J. Biochem. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||J Biochem . 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||2514185|||28453851|||Biochim Biophys Acta. 2004 May 6;1698(2):239-250.|||2514185|||J. Biochem. 1989; 106: 663-668. doi: 10.1093/oxfordjournals.jbchem.a122913." 18 FPDB00020 AP00212|||AP00212|||Polyphemusin-2|||DRAMP02935|||Polyphemusin-2|||AP00212|||DRAMP02935 RRWCFRVCYKGFCYRKCR Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1||Anti-E. coli K12, activity value is MIC = 12.5 ug/ml||Anti-S. Minnesota 1114W or R595, activity value is MIC = 3.1||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 6.3||Anti-and C. albicans M9, activity value is MIC = 6.3 ug/ml||Antibacterial||Antimicrobial||Antifungal ; Candida albicans M9||Anti-Active against Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1 Atlantic Limulus polyphemus|||Atlantic Limulus polyphemus|||Limulus polyphemus [Atlantic horseshoe crab]|||Limulus polyphemus (Atlantic horseshoe crab)|||Atlantic Limulus polyphemus|||Limulus polyphemus (Atlantic horseshoe crab) Bridge Moderate hemolytic activity (45% hemolysis at 20 μM) "J. Biochem. 1989; 106: 663-668. PubMed|||J. Biochem. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||J Biochem . 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||2514185|||J Biochem. 1989 Oct;106(4):663-668.|||2514185|||J. Biochem. 1989; 106: 663-668. doi: 10.1093/oxfordjournals.jbchem.a122913.|||J Biochem. 1989 Oct;106(4):663-668.Biochim Biophys Acta. 2004 May 6;1698(2):239-250.|||1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913." 18 FPDB00034 AP00277|||AP00277|||Clavanin-B|||DRAMP02598|||Clavanin-B|||AP00277|||DRAMP02598 " VFQFLGRIIHHVGNFVHGFSHVF" Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-L. monocytogenes EGD and C. albicans in radial diffusion assays . Recent microdilution assays revealed that the MIC value was reduced 32 fold against E. faecalis ATCC 29212, activity value is MIC = 8 ug/ml||Anti-while the activity against C. albicans ATCC 10231, activity value is MIC = 64 ug/ml||Antibacterial||Antimicrobial||Antifungal ; E.coli||L.monocytes||C.albicans invertebrate Styela clava|||invertebrate Styela clava|||Styela clava [Sea squirt]|||Styela clava (Sea squirt)|||invertebrate Styela clava|||Styela clava (Sea squirt) Alpha helix N/A "FEBS Lett. 1997; 400:158-162. PubMed.|||FEBS Lett. 1997; 400:158-162. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023|||FEBS Lett . 1997 Jan 3;400(2):158-62. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023|||9001389|||FEBS Lett. 1997 Jan 3;400(2):158-162.|||9001389|||FEBS Lett. 1997; 400:158-162. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023|||FEBS Lett. 1997 Jan 3;400(2):158-162.|||1997 Jan 3;400(2):158-62. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023" 23 FPDB00036 AP00310|||AP00310|||LL-37|||LL-37|||AP00310 LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||Chemotactic||Anti-MRSA||Enzyme inhibitor||anti-TB||anti-sepsis||Synergistic AMPs||Hemolytic||Antibiofilm||Wound healing||Anticancer||Anti-L. monocytogenes EGD, activity value is MIC = 1.5 ug/ml||Antibacterial||Anti-S. aureusNCTC 6571, activity value is MIC = 19.3||Anti-E. coli ATCC 25922, activity value is MIC = 9.8||Anti-27367675: E.coli K88, activity value is MIC = 61||Anti-E.coli CVCC245, activity value is MIC = 61||Anti-S.aureus CVCC 26003, activity value is MIC = 36||Anti-S.aureus ATCC 25923, activity value is MIC = 58||Anti-Listeria monocytogene CVCC 1599, activity value is MIC = 13||Anti-Micrococcus luteus CVCC 28001, activity value is MIC = 90||Anti-A. baumannii ATCC 19606, activity value is MIC = 4 ug/ml||Anti-29022391 : S. mutans, activity value is MIC = 250 ug/ml||Anti-A. israelii, activity value is MIC = 7.81 ug/ml||Anti-E. faecalis, activity value is MIC = 2000 ug/ml||Anti-31417238: Streptococcus agalactiae NEM 316, activity value is MIC = 90||Anti-C-terminal:COOH): A. baumannii 6043, activity value is MIC = 14.2 uM||Anti-P. aeruginosa ATCC 19660, activity value is MIC = 28.5 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 28.5 uM||Anti-28649410: P. aeruginosa ATCC 9027, activity value is EC50 = 0.525 uM||Anti-P. aeruginosa PAO1 (pTDKGFP, activity value is EC50 = 0.599 uM||Anti-F. novicida U112, activity value is EC50 = 0.0534 uM||Anti-B. thailandensis E264, activity value is EC50 = 1.88 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 0.552 uM||Anti-31016971: Staphylococcus aureus SA113 WT, activity value is MIC = 256 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 256 uM gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||Homo sapiens|||Homo sapiens [Human]|||Homo sapiens [Human]|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes Helix Moderate hemolytic activity (60% hemolysis at 50 μM)|||hRBC (4.47 (±0.35)% hemolysis at 175 ug/ml), Sheep RBC (HC₅₀=32 ± 0.68 ug/ml)|||hRBC (4.47 (±0.35)% hemolysis at 175 ug/ml), Sheep RBC = (HC50=32 ± 0.68 ug/ml) "Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R. T.1996 Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||Eur J Biochem . 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||28476579|||28408902, 30076860, 28400226, 27367675, 30076864, 30043322, 29022391, 31417238, 31396193, 31016971|||35254120|||28408902, 30076860, 28400226, 27367675, 30076864, 30043322, 29022391, 31417238, 31396193, 31016971||Refer 30076860||Refer PubMed ID: 30076864||Refer PubMed ID: 30043322|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed" 37 FPDB00045 AP00445|||AP00445|||RTD-1|||DRAMP02642|||AP00445|||DRAMP02642|||AP00445|||DRAMP02642 GFCRCLCRRGVCRCICTR Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Anti-toxin||Enzyme inhibitor||Active against S. aureus 502a or MRSA||L. monocytogenes||E. coli ML 35||S. typhimurium||C. albicans 16820||and C. neoformans. Theta-defensins are particularly important for antifungal activity of the granule extracts as alpha-defensins are poorly active (Tongaonkar P et al 2011 J Leuko Biol 89||283-90). It is also active against HIV-1. RTD-1 inhibits human Papillomavirus (hrHPV||nonenvelope DNA virus) infection through a mechanism involving capsid clustering that inhibits virions from binding to cell surface receptor complexes .||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram- leukocytes, Rhesus Macaque (Macaca mulatta)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus macaque)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus macaque) Beta||Beta strand (4 strands; 10 residues) Strong hemolytic activity (100% hemolysis at 5 μM)|||No hemolysis information or data found in the reference(s) presented in this entry Science. 1999 Oct 15;286(5439):498-502|||Science. 1999 Oct 15;286(5439):498-502||Skeate et al., 2020|||Science. 1999 Oct 15;286(5439):498-502||Skeate et al., 2020|||11675394|||Science. 1999 Oct 15;286(5439):498-502.|||Science. 1999 Oct 15;286(5439):498-502||Skeate et al., 2020|||Science. 1999 Oct 15;286(5439):498-502.J Leukoc Biol. 2001 Sep;70(3):461-464.J Biol Chem. 2002 Feb 1;277(5):3079-3084.|||Science. 1999 Oct 15;286(5439):498-502|||Science. 1999 Oct 15;286(5439):498-502. 18 FPDB00046 AP00449|||AP00449|||Alpha-MSH|||Alpha-MSH|||AP00449|||DRAMP02876 SYSMEHFRWGKPV "Anti-Gram+||Antiviral||Antifungal||candidacidal||Anti-HIV||Antibacterial||Gram-positive bacterium: Staphylococcus aureus. Yeast: Candida albicans.||Antimicrobial" Brain, Homo sapiens|||Brain, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens [Human]|||Brain, Homo sapiens|||Bos taurus (Bovine) N/A "The document provides hemolytic values for some peptide compounds, as follows: - DNal: Hemolysis rate is 7% ± 2.1% at a concentration of 100 μM. - Peptide 3: Hemolysis rate is 23% ± 0.1% at a concentration of 100 μM. - Peptide 4: Hemolysis rate is 30% ± 0.2% at a concentration of 100 μM. - Peptide 8: Hemolysis rate is 24% ± 0.4% at a concentration of 100 μM. - Peptide 9: Hemolysis rate is 49% ± 4.1% at a concentration of 100 μM. - Peptide 10: Hemolysis rate is 34% ± 1% at a concentration of 100 μM. These data indicate that different peptide compounds have varying hemolytic effects on red blood cells at different concentrations. Some peptides show certain hemolytic activity at higher concentrations, but the overall hemolysis rate is relatively low, suggesting a certain safety potential." J Leukoc Biol 2000; 67(2): 233-9|||J Leukoc Biol 2000; 67(2): 233-9|||10670585|||10670585|||J Leukoc Biol 2000; 67(2): 233-9|||J Leukoc Biol 2000; 67(2): 233-239. 13 FPDB00047 AP00451|||AP00451|||HBD1|||DRAMP02722 DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Channel inhibitors||Synergistic AMPs||Anticancer||While the reduced form is active against both Gram+ and Gram- bacteria||the oxidized form is only active against Gram- bacteria with little effect on cell envelope . Interestingly||it inhibits the growth of clinical S. aureus strains but NOT lab strains. It was observed that hBD-1 from human platelets can cluster bacteria and signals NETs formation .||Antimicrobial||Antibacterial airway, hemofiltrates, urine, kidney; keratinocytes; skin; platelets; oral saliva; milk, mammary gland epithelium, colonic mucosa, Homo sapiens|||airway, hemofiltrates, urine, kidney; keratinocytes; skin; platelets; oral saliva; milk, mammary gland epithelium, colonic mucosa, Homo sapiens|||Synthetic construct Combine Helix and Beta structure Moderate hemolytic activity (50% hemolysis at 50 µM) "FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed|||Bensch KW, Raida M, Mägert HJ, Schulz-Knappe P, Forssmann WG.1995 FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||1995 Jul 17;368(2):331-5. doi: 10.1016/0014-5793(95)00687-5.||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||FEBS Lett. 1995 Jul 17;368(2):331-5. doi: 10.1016/0014-5793(95)00687-5.||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||FEBS Lett . 1995 Jul 17;368(2):331-5. doi: 10.1016/0014-5793(95)00687-5.||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||Pongo pygmaeus (Bornean orangutan)||Immunogenetics. 2002 Feb;53(10-11):907-913.Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.|||FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed" 36 FPDB00051 AP00505|||AP00505|||Histatin5|||DRAMP03580|||Histatin5|||AP00505|||DRAMP03580 DSHAKRHHGYKRKFHEKHHSHRGY Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Enzyme inhibitor||Anti-C. albicans, activity value is LD50 = 2.3 ug/ml||Anti-and E. faecium . Also active against bacteria A.actinomycetemcomitans, activity value is ED50 > 100 uM||Anti-S. mutans cariogenic bacteria, activity value is ED50 = 92 uM||Anti-C. albicans DIS or azole resistant, activity value is ED50 = 6.4||Anti-C. glabrata or fluconazole resistant, activity value is ED50 = 38.7||Anti-C. krusei, activity value is ED50 = 6.47 uM||Anti-and C. neoformans CN2 or amphotericin B resistant, activity value is ED50 = 3.71||Anti-and S. cerevisiae, activity value is MIC = 74 uM||Antibacterial||Antimicrobial||Anti-Streptococcus mutans U159, activity value is MIC = 234 ug/ml||Anti-Candida albicans ATCC10231, activity value is IC50 = 8.5 ug/ml||Anti-31417503: C. albicans ATCC 90028, activity value is MIC = 64.45 ug/ml||Anti-11302797: Candida albicans, activity value is LD50 = 7.3 salivary glands, Homo sapiens|||salivary glands, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||Homo sapiens [Human]|||salivary glands, Homo sapiens|||Homo sapiens (Human) Helix||Alpha helix Streptococcus mutans U159 (MIC= 234 ug/ml), Candida albicans ATCC10231 (IC50= 8.5 ug/ml); Refer PubMed ID- 31417503: C. albicans ATCC 90028 (MIC = 64.45 ug/ml); Refer PubMed ID- 11302797: Candida albicans (LD50 = 7.3 ± 0.52 ug/ml); Refer PubMed ID- 3286634: C. albicans ( 100 % inhibition at 54 nmol) J Biol Chem. 1988 Jun 5;263(16):7472-7.|||J Biol Chem. 1988 Jun 5;263(16):7472-7.||Data from ref for AP504||Du H et al., 2017||Luque-Ortega et al., 2008|||J Biol Chem. 1988 Jun 5;263(16):7472-7.||Data from ref for AP504||Du H et al., 2017||Luque-Ortega et al., 2008|||34417532, 33740624, 31417503, 11302797, 3286634|||J Biol Chem. 1988 Jun 5;263(16):7472-7477.|||34417532, 33740624, 31417503, 11302797, 3286634|||J Biol Chem. 1988 Jun 5;263(16):7472-7.||Data from ref for AP504||Du H et al., 2017||Luque-Ortega et al., 2008|||J Biol Chem. 1988 Jun 5;263(16):7472-7477. 24 FPDB00053 AP00524|||AP00524|||HBD2|||Human beta-defensin-2 WT hBD - 2|||AP00524|||DRAMP03598 " GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP" Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Chemotactic||Anti-toxin||Channel inhibitors||Synergistic AMPs||Antibiofilm||Wound healing||Anti-synthetic: Active against E. coli DSM1103, activity value is MIC = 18.8 ug/ml||Anti-K. pneumoniae DSM681, activity value is MIC = 37.5 ug/ml||Anti-P. aeruginosa DSM1128, activity value is MIC = 25 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 100 ug/ml||Anti-and S.pneumoniae DSM11865, activity value is MIC = 300 ug/ml||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram- airway, skin, lung, trachea epithelia, and uterus, oral (saliva); Homo sapiens|||airway, skin, lung, trachea epithelia, and uterus, oral (saliva); Homo sapiens|||Synthetic construct|||Homo sapiens [Human]|||airway, skin, lung, trachea epithelia, and uterus, oral (saliva); Homo sapiens|||Homo sapiens (Human) Combine Helix and Beta structure [Ref.15625724] It is slightly hemolytic (<12%) against human erythrocytes at the highest concentration of 500 ug/ml. "Nature. 1997 Jun 26;387(6636):861. PubMed.|||1997 Jun 26;387(6636):861. doi: 10.1038/43088.||see ref AP1315|||Nature. 1997 Jun 26;387(6636):861. doi: 10.1038/43088.|||Nature . 1997 Jun 26;387(6636):861. doi: 10.1038/43088.||see ref AP1315|||9727055|||Nature. 1997 Jun 26;387(6636):861. PubMed.|||Nature. 1997 Jun 26;387(6636):861.J Biol Chem. 2000 Oct 20;275(42):32911-32918.Plant Cell Rep. 2007 Aug;26(8):1391-1398." 41 FPDB00057 AP00599|||AP00599|||Brevinin-2-related peptide|||DRAMP01873|||Brevinin-2-related peptide|||AP00599|||DRAMP01873 GIWDTIKSMGKVFAGKILQNL Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Anti-E. coli, activity value is MIC = 13||Anti-S. aureus or MRSA, activity value is MIC = 25 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Anti-Escherichia coli, activity value is MIC = 13 uM||Anti-Staphylococcus aureus, activity value is MIC = 25 uM||Anti-Candida albicans, activity value is MIC = 25 uM||Anti-19793185 : E. coli, activity value is MIC = 6.25 uM||Anti-S. aureus, activity value is MIC = 12.5 uM||Anti-A. baumannii, activity value is MIC = 6.25 uM||Anti-31549575 : Staphylococcus aureus, activity value is MIC = 16||Anti-Escherichia coli, activity value is MIC = 32 uM||Anti-Candida albicans, activity value is MIC = 16 uM||Anti-Candida albicans, activity value is MIC = 70 uM mink frog, Rana septentrionalis, North America|||Rana septentrionalis (mink frog)|||mink frog, Rana septentrionalis, North America|||Rana septentrionalis (mink frog) N/A "The document explicitly provides the hemolytic values of five major antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), expressed as the concentration required to induce 50% hemolysis of human red blood cells (HC₅₀). The specific data are as follows: Brevinin-1SPa: The hemolytic concentration HC₅₀ is 7 μM, and its minimum inhibitory concentrations (MICs) against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans) are 13 μM, 3 μM, and 6 μM, respectively. Brevinin-1SPb: hemolytic activity, HC₅₀ = 25 μM; MIC values against Escherichia coli, Staphylococcus aureus, and Candida albicans are 50 μM, 6 μM, and 13 μM, respectively. Brevinin-1SPd: hemolytic activity HC₅₀ = 8 μM; the MIC values against Escherichia coli, Staphylococcus aureus, and Candida albicans are all 3 μM. Temporin-1SPb: hemolytic activity, HC₅₀ = 60 μM; only a MIC of 6 μM against Staphylococcus aureus was detected, while the MICs against Escherichia coli and Candida albicans were not determined (ND). Brevinin-2-related peptide: hemolytic activity, HC₅₀ = 70 µM; MIC values against Escherichia coli, Staphylococcus aureus, and Candida albicans are 13 µM, 25 µM, and 25 µM, respectively.|||The document mentioned hemolysis-related content, and the specific hemolytic values are as follows: - Brevinin-1SPa: The concentration causing 50% hemolysis of human red blood cells (HC₅₀) is 7 μM. - Brevinin-1SPb: HC₅₀ is 25 μM. - Brevinin-1SPd: HC₅₀ is 8 μM. - Temporin-1SPb: HC₅₀ is 60 μM. - Brevinin-2 related peptides: HC₅₀ is 71 μM.|||Human erythrocytes ( HC50 = 70 uM ); Refer PubMed ID - 19793185: hRBC(LC50= 90 uM)|||In Document 2 (Comparative Biochemistry and Physiology, Part C 2004), among the antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), brevinin-1SPa has an HC₅₀ of 7 μM for human red blood cells, brevinin-1SPb has an HC₅₀ of 25 μM, brevinin-1SPd has an HC₅₀ of 8 μM, temporin-1SPb has an HC₅₀ of 60 μM, and brevinin-2 related peptide has an HC₅₀ of 70 μM.|||[Ref.15556063]HC50=70 uM against human erythrocytes|||Human erythrocytes ( HC50 = 70 uM ); Refer PubMed ID - 19793185: hRBC(LC50= 90 uM)|||[Ref.15556063]HC50=70 uM against human erythrocytes|||The document mentions the hemolytic activity values of several antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), expressed as HC_{50}, which is the peptide concentration causing 50% hemolysis. The details are as follows: - Brevinin-1SPa: HC_{50} = 7 μM - Brevinin-1SPb: HC_{50} = 25 μM - Brevinin-1SPd: HC_{50} = 8 μM - Temporin-1SPb: HC_{50} = 60 μM - Brevinin-2-related peptide: HC_{50} = 70 μM These values reflect the hemolytic capability of different peptides on human red blood cells; the lower the value, the stronger the hemolytic activity." Comp. Biochem. Physiol. C 2004; 139: 31-38|||omp. Biochem. Physiol. C 2004; 139: 31-38|||15556063, 19793185, 31549575|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.||Ref.15556063|||15556063||Ref.15556063|||15556063, 19793185, 31549575|||Comp. Biochem. Physiol. C 2004; 139: 31-38|||Ref.15556063 21 FPDB00062 AP00724|||AP00724|||RTD-2|||DRAMP31352|||AP00724|||DRAMP31352 " GVCRCLCRRGVCRCLCRR" Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Antibacterial||Antimicrobial Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta (Rhesus macaque) Bridge Strong hemolytic activity (100% hemolysis at 5 μM) J Leukoc Biol 2001; 70:461-464|||J Leukoc Biol 2001; 70:461-464|||11675394|||J Immunol. 2004 Jul 1;173(1):515-20.|||J Leukoc Biol 2001; 70:461-464|||J Immunol. 2004 Jul 1;173(1):515-20. 18 FPDB00063 AP00725|||AP00725|||Rhesus theta defensin-1/3, subunit A precursor|||DRAMP31353|||AP00725|||Rhesus theta defensin-1/3, subunit A precursor|||DRAMP31353 " GFCRCICTRGFCRCICTR" Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Antibacterial||Antimicrobial||Antiviral ; Staphylococcus aureus 502a||Escherichia coli ML35||and yeast forms of Candida albicans 16820 and Cryptococcus neoformans 271A||HIV Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque) Bridge Strong hemolytic activity (100% hemolysis at 5 μM) J Leukoc Biol 2001; 70:461-464|||J Leukoc Biol 2001; 70:461-464|||11675394|||J Immunol. 2004 Jul 1;173(1):515-20.|||J Leukoc Biol 2001; 70:461-464|||https://pubmed.ncbi.nlm.nih.gov/11675394|||J Immunol. 2004 Jul 1;173(1):515-20. 18 FPDB00084 AP01136|||AP01136|||Tricyclon A GGTIFDCGESCFLGTCYTKGCSCGEWKLCYGTN Anti-Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-E.coli, activity value is MIC = 160 uM||Anti-P. aeruginosa, activity value is MIC = 80 uM||Anti-S.aureus, activity value is MIC = 160 uM||Anti-C. albicans, activity value is MIC = 80 uM||Antibacterial Australian flowers, Viola tricolor|||Australian flowers, Viola tricolor|||Viola odorata L. and Viola tricolor L Beta "Under specific hemolysis experimental conditions, after incubating 500 uM of tricyclon A with red blood cells at 37°C for 1 hour, the hemolysis rate was only 2%; under the same conditions, about 100 uM of kalata B1 resulted in a hemolysis rate of 50%. The HD50 of kalata B1 at 37°C is 100 uM, while tricyclon A exhibits very low hemolytic activity.|||The document mentions hemolytic-related data for tricyclon A and kalata B1, as follows: - Tricyclon A: At a concentration of 500 µM, after incubation at 37°C for 1 hour, it only caused 2% hemolysis of red blood cells, indicating very low hemolytic activity. - Kalata B1 (for comparison): Under the same experimental conditions, the half-hemolysis concentration (HD_{50}) is about 100 µM, meaning the concentration that causes 50% hemolysis of red blood cells is 100 µM. These data were obtained through hemolysis experiments using human type A red blood cells as the experimental subject, with a 1% Triton X-100 treatment group as the maximum hemolysis control and a PBS treatment group as the minimum hemolysis control. The hemolysis percentage was calculated accordingly." Structure. 2005 May;13(5):691-701|||Structure. 2005 May;13(5):691-701||Strömstedt et al., 2017|||Structure. 2005 May;13(5):691-701|||28669767 33 FPDB00090 AP01223|||AP01223|||Ascaphin-8|||Ascaphin-8|||AP01223|||DRAMP01847|||AP01223|||DRAMP01847 " GFKDLLKGAAKALVKTVLF" Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Enzyme inhibitor||Anticancer||Anti-E. coli, activity value is MIC = 6 uM||Anti-P. aeruginosa, activity value is MIC = 13 uM||Anti-E. cloacae, activity value is MIC = 6 uM||Anti-K. pneumoniae, activity value is MIC = 6 uM||Anti-S. epidermidis, activity value is MIC = 6 uM||Anti-Streptococcus Group B, activity value is MIC = 6 uM||Anti-E. faecalis, activity value is MIC = 50 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Anti-Escherichia coli, activity value is MIC = 6 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 50 uM||Anti-Enterobacter cloacae, activity value is MIC = 13 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 25 uM||Anti-Proteus mirabilis, activity value is MIC > 100 uM||Anti-S. epidermidis, activity value is MIC = 25 uM||Anti-E. faecalis, activity value is MIC > 100 uM||Anti-Streptococcus Group B, activity value is MIC = 13 uM||Anti-C. albicans, activity value is MIC = 100 uM||Anti-E. coli ATCC25922, activity value is MIC = 3 uM||Anti-S. aureus ATCC25923, activity value is MIC = 3 uM||Anti-E. coli ML35p, activity value is MIC = 1.6 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 3 uM||Anti-S. aureus multiresistant ATCCBAA-44, activity value is MIC = 3 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 12.5 uM||Anti-A549, activity value is IC50 = 33.79 uM||Anti-C4-2B, activity value is IC50 = 42.91 uM||Anti-HEK293T, activity value is IC50 = 53.67 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Ascaphus truei [Coastal tailed frog]|||Ascaphus truei (Coastal tailed frog)|||Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Ascaphus truei (Coastal tailed frog) Helix "Free acid HC50>200 Amidated HC50=55|||Endogenous peptides: ascaphin-1: Half-maximal hemolytic concentration (HC_{50}) for human red blood cells >200 μM. ascaphin-3: HC_{50} >200 μM. ascaphin-7: HC_{50} >200 μM. ascaphin-8: HC_{50} is 50 μM. Synthetic peptides: ascaphin-1 (free acid form): HC_{50} >200 μM; amidated form: HC_{50} >200 μM. ascaphin-5 (free acid form): HC_{50} >200 μM. ascaphin-8 (amidated form): HC_{50} is 55 μM. The above results were obtained through hemolysis experiments. In the experiments, peptides at different concentrations were incubated with washed human red blood cells for 1 hour, and the degree of hemolysis was measured by absorbance at 450 nm. The 1% Tween 20 treated group was used as the 100% hemolysis control, and HC_{50} was defined as the peptide concentration producing 50% hemolysis.|||Ascaphin-1: HC₅₀ > 200 uM. Ascaphin-3: HC₅₀ > 200 uM. Ascaphin-7: HC₅₀ > 200 uM. Ascaphin-8: Endogenous Ascaphin-8: HC₅₀ = 50 uM. Synthetic amidated Ascaphin-8: HC₅₀ = 55 uM. Ascaphin-5: HC₅₀ > 200 uM.|||Human erythrocytes ( HC50 = 50 uM ); Refer PubMed ID 23094651: Rat RBCs [HC50 = 115 uM], PubMed ID 33932712: Rabbit RBC [HC50 = >100 miroM]|||Human erythrocytes ( HC50 = 50 uM ); Refer PubMed ID 23094651: Rat RBCs [HC50 = 115 uM], PubMed ID 33932712: Rabbit RBC [HC50 = >100 miroM]|||The therapeutic potential of ascaphin-8 as an antiinfective agent is limited by its moderately high haemolytic activity (HC50 ¼ 55 lM) In contrast, ascaphin-1 and ascaphin-5, although displaying high potencies only against Gram-negative bacteria, have very low haemolytic activities (HC50 >200 lM) compared with many other frog skin peptides. By way of comparison, the HC50 values of brevinin-1E from Rana esculenta [22] and temporin L from Rana temporaria [23] are less than 2 lM.|||[Ref.15207717]HC50=50 uM against human erythrocytes|||The document mentions the hemolytic values of various ascaphin peptides (expressed as HC_{50}, which is the peptide concentration that causes 50% hemolysis), as follows: Hemolytic values of endogenous peptides (Table 1) - Ascaphin-1: HC_{50} > 200 μM - Ascaphin-3: HC_{50} > 200 μM - Ascaphin-7: HC_{50} > 200 μM - Ascaphin-8: HC_{50} = 50 μM Hemolytic values of synthetic peptides (Table 2) - Ascaphin-1 (free acid form): HC_{50} > 200 μM - Ascaphin-1 (amidated form): HC_{50} > 200 μM - Ascaphin-5 (free acid form): HC_{50} > 200 μM - Ascaphin-8 (amidated form): HC_{50} = 55 μM|||[Ref.15207717]HC50=50 uM against human erythrocytes|||hemolytic HC50 50 uM. TC50 2.9 uM in CEM-SS cells(Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346)." "Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. doi: 10.1016/j.bbrc.2004.05.141.||Menousek J et al 2012 Int J Antimicrob Agents 39:402|||Comparative Study Biochem Biophys Res Commun . 2004 Jul 16;320(1):170-5. doi: 10.1016/j.bbrc.2004.05.141.|||2004 Jul 16;320(1):170-5. doi: 10.1016/j.bbrc.2004.05.141.||Menousek J et al 2012 Int J Antimicrob Agents 39:402|||15207717, 33932712, 23094651||Refer PubMed ID 23094651|||15207717, 33932712, 23094651||Refer PubMed ID 23094651||Refer PubMed ID 33932712|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed||Menousek J et al 2012 Int J Antimicrob Agents 39:402|||Ref.15207717|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175." 19 FPDB00096 AP01580|||AP01580|||Elafin AQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ Anti-Gram+ & Gram-||Antiviral||Antifungal||Antiparasitic||Anti-HIV||Enzyme inhibitor||Antimalarial||active against P. aeruginosa PAO1 and S. aureus C1705. Active against HIV-1 and HSV-2 (Drannik AG||et al 2013). The anti-HIV activity of Elafin is 130 times more potent than its precursor serine antiprotease trappin-2 (Drannik AG||et al 2012).||Antibacterial ; S. aureus||P. aeruginosa gammadelta T cells, keratinocytes, epithelial cells, skin, Homo sapiens|||skin, Homo sapiens|||Homo sapiens [Human] Beta no hemolytic activity FEBS Lett. 1999 Jun 11;452(3):309-13. doi: 10.1016/s0014-5793(99)00670-5. PubMed|||FEBS Lett. 1999 Jun 11;452(3):309-13. doi: 10.1016/s0014-5793(99)00670-5.|||Scand J Immunol. 2009 Dec;70(6):547-52|||16336202 57 FPDB00102 AP02075|||AP02075|||CCL20|||DRAMP03555 " SNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM" Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Anti-HIV||Chemotactic||Antibiofilm||Anti-Gram- P. aeruginosa PA01, activity value is LD50 = 1.1 ug/ml||Anti-M. catarrhalis ATCC43627, activity value is LD50 = 0.9 ug/ml||Anti-S. pyogenes ATCC14289, activity value is LD50 = 0.2 ug/ml||Anti-E. faecium 1438, activity value is LD50 = 4.5 ug/ml||Anti-C. albicans 90028, activity value is LD50 = 25 ug/ml||Anti-and C. neoforman 96-1043, activity value is LD50 = 80 ug/ml||Anti-S. coag. neg. spp, activity value is MIC = 1.58 uM||Anti-Propionibacterium spp, activity value is MIC = 5.23 uM||Anti-S. aureus, activity value is MIC = 5.54 uM||Anti-and C. albicans, activity value is MIC = 0.09 uM||Antibacterial ; Escherichia coli ATCC25922||Staphylococcus aureus ATCC29213||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- Skin, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human) Combine Helix and Beta structure Skin, Homo sapiens||At a concentration of 20 μM, the hemolysis rate is < 10%. "J Leukoc Biol. 2003 Sep;74(3):448-55. Pub-Med. GenBank:NP_001123518.1.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.||Ramamourthy et al., 2019|||https://pubmed.ncbi.nlm.nih.gov/12949249|||J Leukoc Biol . 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||J Biol Chem. 2002 Oct 4;277(40):37647-54." 69 FPDB00160 AP00054|||AP00054|||Maximin-6|||BLP-7|||DRAMP01112|||Maximin-6|||BLP-7|||AP00054|||DRAMP01112 GIGGALLSAGKSALKGLAKGLAEHFAN Anti-E. coli, activity value is MIC = 6.3 uM||Anti-S. aureus, activity value is MIC = 6.3 uM||Anti-2012. ALso has anticancer effects on human hepatic adenocarcinoma SK-HEP-1 cells, activity value is IC50 = 0.99 uM||Anti-Hep G2 cells, activity value is IC50 = 2.8 uM||C. albicans||Anti-E.coli, activity value is MIC = 16 ug/ml||Anti-S.aureus, activity value is MIC = 16 ug/ml||Anti-C.albicans, activity value is MIC = 32 ug/ml||Antimicrobial||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Anticancer Oriental fire-bellied toad/frog, Bombina orientalis, Asia|||Oriental fire-bellied toad/frog, Bombina orientalis, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina orientalis|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Bombina orientalis|||Oriental fire-bellied toad/frog, Bombina orientalis, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) N/A Shows little hemolytic activity|||Human RBCs (>80% hemolysis at 256 ug/ml) "Miele R, Borro M, Fiocco D, Barra D, Simmaco M.2000 Peptides 2000; 21:1681-1686. PubMed.||Zhou et al., 2017|||Peptides . 2000 Nov;21(11):1681-6. doi: 10.1016/s0196-9781(00)00317-x.||Zhou et al., 2017|||11835991|||28636781|||Eur J Immunol. 2005 Apr;35(4):1220-1229.|||11835991|||28636781|||Peptides 2000; 21:1681-1686. doi: 10.1016/s0196-9781(00)00317-x.||Zhou et al., 2017|||Eur J Immunol. 2005 Apr;35(4):1220-1229.Peptides. 2002 Mar;23(3):427-435.|||Peptides 2000; 21:1681-1686. PubMed." 27 FPDB00161 AP00090|||1001|||1009|||1017|||1025|||1033|||AP00090|||Gaegurin-6|||DRAMP02296|||Gaegurin-6|||AP00090 FLPLLAGLAANFLPTIICKISYKC Anti-M. luteus, activity value is MIC = 2.5 ug/ml||Anti-S. epidermidis, activity value is MIC = 10 ug/ml||Anti-B. subtilis, activity value is MIC = 10 ug/ml||Anti-K. pneumoniae, activity value is MIC = 50 ug/ml||Anti-S. dysentariae, activity value is MIC = 50 ug/ml||Anti-P.putida, activity value is MIC = 150 ug/ml||Anti-P.aeruginosa, activity value is MIC = 150 ug/ml||Anti-E. coli, activity value is MIC = 100 ug/ml||Anti-S. cerevisiae, activity value is MIC = 50 ug/ml||Anti-C. albicans, activity value is MIC = 50 ug/ml||activity value is IC50 = 6.49 ug/ml||activity value is IC50 = 5.62 ug/ml||activity value is IC50 = 5.75 ug/ml||activity value is IC50 = 4.91 ug/ml||activity value is IC50 = 4.88 ug/ml||Antibacterial||Antifungal||Antiparasitic||Anti-Micrococcus luteus, activity value is MIC = 2.5 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 10 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 10 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 50 ug/ml||Anti-Shigella dysentariae, activity value is MIC = 50 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 100 ug/ml||Anti-Eshchericia coli, activity value is MIC = 50 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC = 50 ug/ml||Anti-Candida albicans, activity value is MIC = 50 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 200 ug/ml||Anti-Proteus mirabilis, activity value is MIC > 200 ug/ml||Anti-Serratia marcescens, activity value is MIC > 200 ug/ml||Anti-Gram+ & Gram-||candidacidal||Anticancer skin, Korean wrinkled frog Rana rugosa, Asia|||skin, Korean wrinkled frog Rana rugosa, Asia|||Rana rugosa [Japanese wrinkled frog]|||Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)|||Rana rugosa [Japanese wrinkled frog]|||skin, Korean wrinkled frog, Glandirana emeljanovi, previously Rana rugosa, Asia N/A "Hemolytic activity test results: At a concentration of 100 μg/ml, the hemolysis rates of gaegurin 1-6 on human red blood cells were all below 2%, while the positive control melittin showed a hemolysis rate of 37.67% at 10 μg/ml and reached 98.92% at 100 μg/ml. Sample data: gaegurin 1: Hemolysis rate 0.59% at 100 μg/ml. gaegurin 2: Hemolysis rate 0.82% at 100 μg/ml. gaegurin 3: Hemolysis rate 1.20% at 100 μg/ml. gaegurin 4: Hemolysis rate 1.67% at 100 μg/ml. gaegurin 5: Hemolysis rate 1.01% at 100 μg/ml. gaegurin 6: Hemolysis rate 0.86% at 100 μg/ml.|||Micrococcus luteus ( MIC = 2.5 ug/ml), Staphylococcus epidermidis ( MIC = 10 ug/ml), Bacillus subtilis ( MIC = 10 ug/ml), Klebsiella pneumoniae ( MIC = 50 ug/ml), Shigella dysentariae ( MIC = 50 ug/ml), Pseudomonas putida ( MIC = 50 ug/ml), Pseudomonas aeruginosa ( MIC = 100 ug/ml), Eshchericia coli ( MIC = 50 ug/ml), Saccharomyces cerevisiae ( MIC = 50 ug/ml), Candida albicans ( MIC = 50 ug/ml), Salmonella typhimurium ( MIC = 200 ug/ml), Proteus mirabilis ( MIC = >200 ug/ml), Serratia marcescens ( MIC = >200 ug/ml)|||In Document 8 (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1994), six gaegurin family antimicrobial peptides (gaegurin 1-6) were isolated from the skin of the wrinkled frog (Rana rugosa), and their hemolytic activity was extremely low; at a concentration of 100 µg/ml, the hemolysis rates were 0.59% for gaegurin 1, 0.82% for gaegurin 2, 1.20% for gaegurin 3, 1.67% for gaegurin 4, 1.01% for gaegurin 5, and 0.86% for gaegurin 6; as a control, the bee venom hemolytic peptide had a hemolysis rate of 98.92% at 100 µg/ml." "Park JM, Jung J-E, Lee BJ.1994 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-54.PubMed.|||Biochem Biophys Res Commun . 1994 Nov 30;205(1):948-54. doi: 10.1006/bbrc.1994.2757.|||7999137|||Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.||Ref.7999137|||7999137|||Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-54.doi: 10.1006/bbrc.1994.2757.|||Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-54.PubMed." 24 L FPDB00162 AP00094|||1427|||AP00094|||Temporin-A FLPLIGRVLSGIL Anti-S. pyogenes beta hem. group A, activity value is MIC = 1||Anti-E. coli, activity value is MIC = 6.2||Anti-and A. baumannii, activity value is MIC = 24 uM||Anti-including parasites L. donovani and L. mexicana . Also active against C. jeikeium ATCC BAA-949, activity value is MIC = 8 uM||15% Cytotoxicity at 0.5 ug/ml||Anti-B. megateriurn Bml I, activity value is MIC = 1.2 uM||Anti-S. aureus Cowanl, activity value is MIC = 2.3 uM||Anti-Y. pseudotuberculosis, activity value is MIC = 2 uM||Anti-S. pyogenes/3 hem. group A, activity value is MIC = 2 uM||Anti-E. coli D21, activity value is MIC = 11.9 uM||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Chemotactic||Wound healing||Anticancer European common frog, Rana temporaria|||European common frog, Rana temporaria|||Rana temporaria [european common frog] Helix "Hemolytic activity test results: Temporin A and Temporin B both showed less than 1% hemolysis of human red blood cells at a concentration of 120 μM, whereas bee venom peptide (melittin) can cause more than 90% red blood cell hemolysis at 0.9 μM. Example data: Temporin A: Hemolytic concentration > 120 μM. Temporin B: Hemolytic concentration > 120 μM. Melittin: Hemolytic concentration 0.9 μM.|||The hemolytic concentration of temporin A on human red blood cells is >120 µM. The hemolytic concentration of temporin B on human red blood cells is >120 µM. The hemolytic concentration of melittin on human red blood cells is 0.9 µM. The hemolytic concentration of melittin-like peptide (MLP) on human red blood cells is 0.5 µM. The hemolytic concentration of defensin 1 (esculentin 1) on human red blood cells is >200 µM. The hemolytic concentration of cecropin A on human red blood cells is >400." "Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.1996 Eur J Biochem. 1996 Dec 15;242(3):788-92. PubMed.||Swithenbank et al., 2020||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90|||Eur J Biochem . 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||Swithenbank et al., 2020||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90|||9022710, 30043322|||Eur J Biochem. 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||Swithenbank et al., 2020||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90|||1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90|||Eur J Biochem. 1996 Dec 15;242(3):788-92. PubMed." 13 L FPDB00168 AP00144|||1116|||1306|||1307|||1308|||1309|||1310|||1311|||1312|||1313|||1314|||1359|||1365|||1371|||1377|||1383|||1389|||1395|||1401|||1407|||1413|||AP00144|||Magainin-2|||Magainin-2 amide|||DRAMP02271|||Magainin 2|||AP00144 GIGKFLHSAKKFGKAFVGEIMNS Anti-E. coli D31, activity value is MIC = 5 ug/ml||Anti-S. epidermidis, activity value is MIC = 10 ug/ml||Anti-C. freundii, activity value is MIC = 30 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-C. albicans, activity value is MIC = 80 ug/ml||Anti-and S. marcescens, activity value is MIC = 100 ug/ml||activity value is IC50 = 110 uM||activity value is IC50 = 32.3 uM||activity value is IC50 = 54.1 uM||activity value is IC50 = 28.6 uM||activity value is IC50 = 484 uM||activity value is IC50 = 52.4 uM||activity value is IC50 = 57.8 uM||activity value is IC50 = 135.3 uM||activity value is IC50 = 31 uM||activity value is IC50 = 59.4 uM||activity value is IC50 > 150 ug/ml||activity value is IC50 > 200 ug/ml||Antibacterial||Antifungal||Antiparasitic||Anti-Escherichia coli D31, activity value is MIC = 5 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 10 ug/ml||Anti-Escherichia coli, activity value is MIC = 50 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 10 ug/ml||Anti-Citrobacter freundii, activity value is MIC = 30 ug/ml||Anti-Enterobacter cloacae, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 100 ug/ml||Anti-Serratia marcescens, activity value is MIC = 100 ug/ml||Anti-Proteus mirabilis, activity value is MIC > 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Streptococcus fecalis, activity value is MIC > 100 ug/ml||Anti-Candida albicans, activity value is MIC = 80 ug/ml||Anti-Streptococcus fecalis Paramecium caudatum, activity value is MIC = 10 ug/ml||Anti-Euglena gracilis ] [ - E.coli ATCC 25922, activity value is MIC = 62||Anti-Klebsiella Pneumonae ATCC 13883, activity value is MIC = 125||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 125||Anti-Candida ablicansATCC 14053, activity value is MIC = 250||Anti-Gram+ & Gram-||Antiviral||candidacidal||Insecticidal||Spermicidal||anti-sepsis||Antimalarial||Synergistic AMPs||Wound healing||Anticancer skin; Stomach, African clawed frog, Xenopus laevis, Africa|||skin; Stomach, African clawed frog, Xenopus laevis, Africa|||Xenopus laevis [African clawed frog]|||Xenopus ruwenzoriensis (Uganda clawed frog)|||skin; Stomach, African clawed frog, Xenopus laevis, Africa Helix "Since these amphiphilic peptides may be membrane dis ruptive (12), magainin 2 was assayed for hemolytic activityagainst human erythrocytes (Fig. 4B). Unlike mellitin, ahemolytic, amphiphilic 26-amino acid peptide from beevenom (12), magainin 2 was not hemolytic up to at least 0.00015 ug/ml in phosphate-buffered normal saline (Fig. 4B). Theabsence of hemolytic activity of magainin 2 is striking in thatit possesses a potential hydrophobic moment very similar tomellitin (12)|||​|||[ Refer PubMed : 3299384 :- Escherichia coli D31 ( MIC = 5 ug/ml), Klebsiella pneumoniae ( MIC = 10 ug/ml), Pseudomonas putida ( MIC = 10 ug/ml), Staphylococcus epidermidis ( MIC = 10 ug/ml), Citrobacter freundii ( MIC = 30 ug/ml), Enterobacter cloacae ( MIC = 50 ug/ml), Escherichia coli ( MIC = 50 ug/ml), Staphylococcus aureus ( MIC = 50 ug/ml), Candida albicans ( MIC = 80 ug/ml), Pseudomonas aeruginosa ( MIC = 100 ug/ml), Serratia marcescens ( MIC = 100 ug/ml), Proteus mirabilis ( MIC = >100 ug/ml), Streptococcus fecalis ( MIC = >100 ug/ml)Paramecium caudatum ( MIC = 10 ug/ml), Amoeba proteus , Euglena gracilis ] [ Refer PubMed : 1717472 :- E.coli ATCC 25922 ( MIC = 62-125 ug/ml), Klebsiella Pneumonae ATCC 13883 ( MIC = 125-250 ug/ml), Pseudomonas aeruginosa ATCC 27853 ( MIC = 125-250 ug/ml), Staphylococcus aureus ATCC 29213 ( MIC = >500 ug/ml), Streptococcus faecalis ATCC 29212 ( MIC = >500 ug/ml), Candida ablicansATCC 14053 ( MIC = 250-500 ug/ml) ], [ Refer Pubmed ID 35073323: Mycoplasma pneumoniae ]|||Xanthomonas axonopodis pv. glycines (MIC = 13 uM), Escherichia coli (MIC = 13 uM), Pseudomonas aeruginosa (MIC = 26 uM)|||In Document 4 (Proc. Natl. Acad. Sci. USA 1987), magainin 1 and magainin 2, isolated from the skin of the African clawed frog (Xenopus laevis), showed no hemolytic activity against human erythrocytes, and no hemolysis was observed even at concentrations up to 150 µg/ml in phosphate-buffered saline.|||Magainin 2 shows no hemolytic activity on human red blood cells even at concentrations as high as 150 µg/ml; whereas melittin, the bee venom peptide, exhibits significant hemolytic effects at low concentrations." "Zasloff M.1987 Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. PubMed.||Peschel et al., 2001|||1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.||see ref AP4787||Peschel et al., 2001|||Proc Natl Acad Sci U S A . 1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.||Peschel et al., 2001|||1717472 , 3299384, 35073323|||23029273|||Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-5453.|||1717472 , 3299384, 35073323||PubMed : 3299384||PubMed : 1717472||Refer Pubmed ID 35073323|||Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.|||1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.|||Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. PubMed." 23 L FPDB00171 AP00166|||AP00166|||Pleurocidin|||DRAMP02350|||AP00166 GWGSFFKKAAHVGKHVGKAALTHYL Anti-Highly active against A. salmonicida 99-1, activity value is MIC = 2 uM||Anti-A. salmonicida 97-4, activity value is MIC = 2 uM||Anti-S. enterica serovar Typhimurium MS7953s or 14028s or I or II, activity value is MIC = 2||Anti-P. aeruginosa K799 or Z61, activity value is MIC = 4||Anti-E. coli CGSC4908 or UB1005 or DC2, activity value is MIC = 2||Anti-S. epidermidis C621, activity value is MIC = 8 uM||Anti-methicillin-resistant S. aureus C623 or MRSA, activity value is MIC = 8 uM||Anti-C. albicans C627, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 2.2||Anti-A. salmonicida, activity value is MIC = 2||Anti-P. aeruginosa, activity value is MIC = 4||Anti-C. aquatilis, activity value is MIC = 2.2||Anti-P. haemolytica, activity value is MIC = 4.4||Anti-positive B. subtilis, activity value is MIC = 1.1||Anti-S. aureus, activity value is MIC = 17.7||Anti-S. epidermidis, activity value is MIC = 8 uM||Anti-UA 140, activity value is MIC = 8||Anti-L. fermenti, activity value is MIC = 2||Anti-Gram+ & Gram-||Antifungal||candidacidal||Chemotactic||Anti-MRSA||Antibiofilm||Anticancer||Antibacterial||Anti-Escherichia coli, activity value is MIC = 2.2||Anti-Leucothrix mucor, activity value is MIC > 35 uM||Anti-Serratia marcescens, activity value is MIC > 35 uM||Anti-Pseudomonas aeruginosa, activity value is MIC > 35 uM||Anti-Aeromonas salmonicida, activity value is MIC = 17.7||Anti-Cytophaga aquatilis, activity value is MIC = 2.2||Anti-Pasteurella haemolytica, activity value is MIC = 4.4||Anti-Salmonella typhimurium I, activity value is MIC = 8.8||Anti-Salmonella typhimurium II, activity value is MIC = 8.8||Anti-Bacillus subtilis, activity value is MIC = 1.1||Anti-Staphylococcus aureus, activity value is MIC = 17.7 the skin mucous secretions, Winter flounder, Pleuronectes americanus|||the skin mucous secretions, Winter flounder, Pleuronectes americanus|||Pseudopleuronectes americanus [Winter flounder]|||Pseudopleuronectes americanus (Winter flounder 4)|||the skin mucous secretions, Winter flounder, Pleuronectes americanus Helix Refer 30508627 Mouse RBC (12% hemolysis at 32 uM) "Cole AM, Weis P, Diamond G.1997 J. Biol. Chem. 1997; 272:12008-12013. Pub-Med.||Tao R et al., 2011|||J. Biol. Chem. 1997; 272:12008-12013. Pub-Med.|||Comparative Study J Biol Chem . 1997 May 2;272(18):12008-13. doi: 10.1074/jbc.272.18.12008.||Tao R et al., 2011|||9115266 , 10898673 , 12950255 , 12878506, 30508627|||J Biol Chem. 1997 May 2;272(18):12008-12013.|||J. Biol. Chem. 1997; 272:12008-12013. doi: 10.1074/jbc.272.18.12008.||Tao R et al., 2011" 25 FPDB00172 AP00191|||AP00191|||Gomesin c|||DRAMP18495|||Gomesin c|||AP00191 QCRRLCYKQRCVTYCRGR Anti-N. asteroides, activity value is MIC = 0.4||Anti-X. campestris, activity value is MIC = 0.4||Anti-S. cerevisiae, activity value is MIC = 0.4||Anti-and B. bassiana, activity value is MIC = 12.5||Anti-Escherichia coli SBS 363, activity value is MIC = 0.32||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 0.64||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 1.28||Anti-Candida albicans MDM8, activity value is MIC = 0.32||Anti-Candida albicans MDM8, activity value is MIC = 2.56||Anti-Aerococcus viridans, activity value is MIC = 0.8||Anti-Bacillus cereus, activity value is MIC = 6.25||Anti-Bacillus megaterium, activity value is MIC = 0.2||Anti-Bacillus thuringiensis, activity value is MIC = 1.6||Anti-Enterococcus faecalis, activity value is MIC = 6.2||Anti-Listeria monocytogenes, activity value is MIC = 0.8||Anti-Micrococcus luteus, activity value is MIC = 0.4||Anti-Pediococcus acidolacrici, activity value is MIC = 3.15||Anti-Staphylococcus aureus, activity value is MIC = 1.6||Anti-Staphylococcus epidermidis, activity value is MIC = 0.8||Anti-Staphylococcus haemolyticus, activity value is MIC = 0.8||Anti-Staphylococcus saprophyticus, activity value is MIC = 0.8||Anti-Streptococcus pyogenes, activity value is MIC = 1.6||Anti-Nocardia asteroides, activity value is MIC = 1.6||Anti-Escherichia coli 1106, activity value is MIC = 0.8||Anti-Escherichia coli D22, activity value is MIC = 0.4||Anti-Escherichia coli D31, activity value is MIC = 0.8||Anti-Escherichia coli SBS363, activity value is MIC = 0.4||Anti-Erwinia carolovora, activity value is MIC = 3.15||Anti-Enterobacter cloacae β12, activity value is MIC = 3.15||Anti-Klebsiella pneumoniae, activity value is MIC = 3.15||Anti-Pseudomonas aeruginosa, activity value is MIC = 1.6||Anti-Salmonella thyphinurium, activity value is MIC = 0.8||Anti-Xhantomonas campestris pv. orizae, activity value is MIC = 3.15||Anti-Alternaria brassicola, activity value is MIC = 0.4||Anti-Aspergillus fumigatus, activity value is MIC = 1.6||Anti-Beauveria bassiana, activity value is MIC = 12.5||Anti-Fusarium culmorum, activity value is MIC = 0.4||Anti-Fusarium oxysporum, activity value is MIC = 0.4||Anti-Neurospora crassa, activity value is MIC = 0.4||Anti-Nectria haematococca, activity value is MIC = 0.2||Anti-Tricoderma viridae, activity value is MIC = 0.4||Anti-Tricophvton mentagrophytes, activity value is MIC = 0.8||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Antimalarial||Anticancer Hemocytes, Acanthoscurria gomesiana|||Hemocytes, Acanthoscurria gomesiana|||Synthetic construct|||Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus)|||Hemocytes, Acanthoscurria gomesiana Beta "Using as control a hemoglobin fragment (33–61 of bovine a-hemoglobin) (26), which exhibits some effect on the viability of the parasite at high concentrations (.40000 uM), gomesin was found to strongly reduce viability even at concentration as low as 2500 uM. In addition, in an hemolytic assay against human erythrocytes, the percentage of cell lysis was found to be dependent of the gomesin (amidated and non-amidated) concentrations tested. From 100 uM (the lowest concentration tested) up to 200 uM, the percentage of hemolysis remains rather low (,5%), whereas increasing the peptide concentration up to 1000 uM results in a rapid and significant elevation of the percentage of cell lysis (up to approximately 16%). However, an increase in the concentra-tion of gomesin of 2 orders of magnitude (final concentration tested of 100000 uM) has only little effect on human eryhtrocyte lysis|||Human erythrocytes (35% Hemolysis at 100 uM|||SK84 was hemolytic to both mouse and human erythrocytes, and only about 0.01% of the hemolysis rate was observed after 1 h incubation in the 1-100 uM concentration range (compared to 100% hemolysis induced by 0.2% Triton X-100).|||Human erythrocytes (35% Hemolysis at 100 uM|||25% hemolysis at 100 uM. Updated 5/2010; 2/2014; 5/2015; 7/2021 GW" "Silva PI Jr, Daffre S, Bulet P.2000 J Biol Chem. 2000 Oct 27;275(43):33464-70. PubMed.|||J Biol Chem . 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200.|||22865764|||J Biol Chem. 2000 Oct 27;275(43):33464-70.||Ref.10942757|||22865764|||J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200.|||J Biol Chem. 2000 Oct 27;275(43):33464-70. PubMed." 18 FPDB00183 AP00281|||AP00281|||Cathelin-related antimicrobial peptide|||DRAMP03405|||AP00281 GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE Anti-E. coli ATCC 25922 or ML35 or D21, activity value is MIC = 0.5||Anti-S. typhimurium ATCC 14028, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 4 uM||Anti-S. marcescens ATCC 8100, activity value is MIC = 4 uM||Anti-P-vulgaris ATCC 13315, activity value is MIC > 64 uM||Anti-S. aureus ATCC 25923 or Cowan I MRSA, activity value is MIC = 32||Anti-S. epidermidis ATCC 12228, activity value is MIC = 16 uM||Anti-S. faecalis ATCC 29212, activity value is MIC = 32 uM||Anti-B. megaterium Bm11, activity value is MIC = 4 uM||Anti-fumgi C-albicans, activity value is MIC > 64 uM||Anti-C. neoformans, activity value is MIC = 16 uM||Anti-and the single-stranded RNA virus respiratory syncytial virus . It also inhibit B. anthracis, activity value is MIC = 8 ug/ml||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-MRSA||Anticancer||Antibacterial||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 uM||Anti-Escherichia coli ML35, activity value is MIC = 2 uM||Anti-Escherichia coli D21, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 4 uM||Anti-Serratia marcescens ATCC 8100, activity value is MIC = 4 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 32 uM||Anti-Staphylococcus aureus Cowan I, activity value is MIC = 32 uM||Anti-Staphylococcus aureus, activity value is MIC > 64 uM||Anti-Staphylococcus aureus, activity value is MIC = 64 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 16 uM||Anti-Streptococcus faecalis ATCC 29212, activity value is MIC = 16 uM||Anti-Bacillus megaterium Bm11, activity value is MIC = 4 uM||Anti-Cryptococcus neoformans, activity value is MIC = 16 uM precursor sequence homology, sequence alignment, other predictions|||precursor sequence homology, sequence alignment, other methods predicted|||precursor sequence homology, sequence alignment, other predictions|||Mus musculus [Mouse]|||Mus musculus (Mouse)|||precursor sequence homology, sequence alignment, other methods predicted Helix||Alpha helix (CD) CRAMP peptide does not lyse human or sheep red blood cell membranes at a concentration of 50 μM, but specific hemolytic values are not mentioned.|||CRAMP is also anticancer (tumor cells A549, K562, Jurkat, IC50 16-28 uM) with 2.2% hemolysis at 100 uM (little hemo.lytic). Change residue 2, 9, or 13 to K made CRAMP-18 anticancer as well but not better than its parent molecule. CRAMP also inactivates Zika virus (ZIKV). Updated 11/2015; 4/2016; 10/2016; 3/2023; seq corrected 5/2023; 6/2024. "Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R.1997 J. Biol. Chem. 1997: 272:13088-13093. PubMed||Blower et al., 2018||Archer NK et al., 2016|||J. Biol. Chem. 1997: 272:13088-13093. PubMed|||J Biol Chem . 1997 May 16;272(20):13088-93. doi: 10.1074/jbc.272.20.13088.||Blower et al., 2018||Archer NK et al., 2016|||9148921|||FEBS Lett. 1996 Aug 5;391(1-2):5-8.|||J. Biol. Chem. 1997: 272:13088-13093. PubMed||Blower et al., 2018||Archer NK et al., 2016|||1997 May 16;272(20):13088-93. doi: 10.1074/jbc.272.20.13088.||Blower et al., 2018" 33 FPDB00185 AP00308|||1420|||AP00308|||Buforin-2|||BF2|||DRAMP01163|||Buforin-2|||AP00308|||DRAMP01163 TRSSRAGLQFPVGRVHRLLRK Anti-Gram+ bacteria B. subtilis, activity value is MIC = 2 ug/ml||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-S. mutans, activity value is MIC = 2 ug/ml||Anti-S. pneumoniae, activity value is MIC = 4 ug/ml||Anti-P. putida, activity value is MIC = 2 ug/ml||Anti-E. coli, activity value is MIC = 4 ug/ml||Anti-S. typhimurium, activity value is MIC = 1 ug/ml||Anti-Serratia sp, activity value is MIC = 4 ug/ml||Anti-C. albicans, activity value is MIC = 1 ug/ml||Anti-C. neoformans, activity value is MIC = 1 ug/ml||Anti-and S. cerevisiae, activity value is MIC = 1 ug/ml||5% Cytotoxicity at 0.5 ug/ml||Anti-ctive against Gram+ bacteria B. subtilis, activity value is MIC = 2 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||Anti-Streptococcus mutans, activity value is MIC = 2 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 4 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 2 ug/ml||Anti-Escherichia coli, activity value is MIC = 4 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 1 ug/ml||Anti-Candida albicans, activity value is MIC = 1 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 1 ug/ml||Antibacterial||Anti-Saccharomyces cerevisiae, activity value is MIC = 1 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||anti-sepsis||Anticancer derivative of buforin I after treatment with endoproteinase, protease digestion|||derivative of buforin I after treatment with endoproteinase, protease digestion|||Bufo gargarizans [Asian toad]|||Sphaenorhynchus lacteus [Orinoco lime treefrog]|||Bufo gargarizans (Asian toad) (Bufo bufo gargarizans)|||derivative of buforin I after treatment with endoproteinase, Sequence truncation, animal-derived, natural derivative|||Bufo gargarizans (Asian toad) (Bufo bufo gargarizans) Helix||Alpha helix Human RBCs (<50% hemolysis at 6.25-200 uM) "Park CB, Kim MS, Kim SC.1996 Biochem. Biophys. Res. Commun. 1996; 218:408-413||Lee 2008 Cancer Lett 271: 47-51|||Biochem. Biophys. Res. Commun. 1996; 218:408-413||Lee 2008 Cancer Lett 271: 47-51|||Lee 2008 Cancer Lett 271: 47-51|||8573171|||30044391|||Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.|||8573171|||Biochem. Biophys. Res. Commun. 1996; 218:408-413||Lee 2008 Cancer Lett 271: 47-51|||Biochem. Biophys. Res. Commun. 1996; 218:408-413" 21 L FPDB00190 AP00366|||AP00366|||Antibacterial peptide BMAP-27|||DRAMO02855|||Antibacterial peptide BMAP-27|||AP00366 GRFKRFRKKFKKLFKKLSPVIPLLHLG Anti-E. coli ATCC 25922 ML-35 or D21, activity value is MIC = 0.5||Anti-S. typhimurium ATCC 14028, activity value is MIC = 1||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-S. marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-S. aureus ATCC 25923 or Cowan 1 MRSA, activity value is MIC = 2||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1 uM||Anti-B. megaterium Bm11, activity value is MIC = 2 uM||Anti-C. albicans, activity value is MIC = 8 uM||Anti-and C. neoformans, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 1 uM||Anti-E. coli ML35, activity value is MIC = 1 uM||Anti-E.coli D21, activity value is MIC = 0.25 uM||Anti-S. typhimurium ATCC 14028, activity value is MIC = 1 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2 uM||Anti-S. aureus Cowan 1, activity value is MIC = 2 uM||Anti-S. aureus MRSA, activity value is MIC = 4 uM||Anti-C.albicans, activity value is MIC = 8 uM||Anti-C.neoformans, activity value is MIC = 4 uM||Anti-E.coli(LOG 2, activity value is MIC = 3.75||Anti-Escherichia coli ATCC25922, activity value is MIC = 1 ug/ml||Anti-E. coli ML35, activity value is MIC = 1 ug/ml||Anti-E. coli D21, activity value is MIC = 0.25 ug/ml||Anti-Salmonella typhimurium ATCC 14028, activity value is MIC = 1 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1 ug/ml||Anti-Serratia marcescens ATCC 8100, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus Cowan 1, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1 ug/ml||Anti-Bacillus megaterium Bm11, activity value is MIC = 2 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 4 ug/ml cattle, Bos taurus|||cattle, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine)|||Bos taurus [Bovine]|||cattle, Bos taurus Helix "The hemolytic activity of the two BMAPs was much lower, when measured on bovine erythrocytes (data not shown). These cells were 5–10-fold less susceptible than human red blood cells to BMAP-28 (3, 6, and 22% hemolysis at 10, 30, and 100000 uM peptide), and virtually unaffected by BMAP-27 even at 100000 uM. We speculate that the different susceptibility of human and bovine red blood cells to these molecules may be accounted for by species-specific differences in the erythrocyte membrane composition, and may reflect the need to protect the host cells from undesired cytotoxic effects. We have also noted that the effects of BMAP-28 on the cell membranes are consistently higher than BMAP-27, in spite of the structural similarity of the two molecules, thus suggesting that minor structural dif-ferences can modulate the activity of these peptides.|||The document explicitly mentions the hemolytic values of two novel antimicrobial peptides (BMAP-27, BMAP-28) and their derivatives (BMAP-27(1–18), BMAP-28(1–18), mBMAP-28) on human red blood cells. The core data are as follows: 1. Hemolytic properties of parent peptides (BMAP-27, BMAP-28). BMAP-28 (for human red blood cells): At a concentration of 3 μM, the hemolysis rate is 14.5%; At a concentration of 100 μM, the hemolysis rate exceeds 90% (specifically 94.1%). BMAP-27 (against human red blood cells): At a concentration of 3 μM, the hemolysis rate is only 3.5%; At a concentration of 100 μM, the hemolysis rate is 32.7%. Its hemolytic effect on bovine red blood cells is significantly lower than that of human red blood cells: BMAP-28 had hemolytic rates of 3%, 6%, and 22% at concentrations of 10 uM, 30 uM, and 100 uM, respectively; BMAP-27 has almost no hemolytic effect on bovine red blood cells even at a concentration of 100 uM. 2. Hemolytic properties of truncated derivatives (BMAP-27(1–18), BMAP-28(1–18)). The hemolytic effect of truncated peptides (retaining only 18 residues at the N-terminus and removing the hydrophobic tail at the C-terminus) is significantly reduced: BMAP-27 (1–18): Has almost no hemolytic activity against human red blood cells (Figure 6 shows no significant hemolytic rate; combined with text description of ""hemolytic effect disappears""). BMAP-28(1–18): hemolytic rate of human red blood cells is significantly lower than that of parent peptides (the curve in Figure 6 is close to baseline, no specific value, but the text clearly states ""hemolytic effect greatly reduced""). 3. Hemolytic properties of modified derivatives (mBMAP-28). Significant loss of hemolytic activity in mBMAP-28 (replacement of hydrophobic residues at the C-terminal for hydrophilic residues): At a concentration of 100 μM, the hemolytic rate for human red blood cells is only 3.3%, far lower than the 94.1% of the parent peptide BMAP-28. Additional notes Hemolysis detection method: Using standard hemolysis experiments, 10% (v/v) red blood cell suspension and peptides of different concentrations were incubated at 37°C for 15 minutes to measure absorbance at 415nm, using complete hemolysis induced by 0.2% Triton X-100 as a 100% control. Relationship between hemolysis and antibacterial activity: The hemolytic concentration of parental peptides (≥3 uM) is much higher than that of their antibacterial activity concentration (MIC: 0.25–4 uM); Truncated/modified derivatives retain antibacterial activity while significantly reducing hemolytic activity and improving targeted selectivity.|||The document clearly mentions the hemolytic values of BMAP-27, BMAP-28, and their analogues (truncated or modified forms) on human and bovine red blood cells. The core data are as follows: I. Hemolytic values for human red blood cells (key indicators) Measured by standard hemolysis experiments, presented as ""peptide concentration (uM) - hemolysis rate (%)"", the results are the average of multiple independent experiments (S.E. ≤1.8): 1. BMAP-28 3 uM: 14.5% 100 uM: >90% (specifically 94.1%) 2. BMAP-27 3 uM: 3.5% 100 uM: 32.7% 3. Truncated forms: BMAP-27(1–18), BMAP-28(1–18) BMAP-27(1–18): nearly no hemolytic activity (no specific value given, only mentioned as ""hemolytic effect disappeared""). BMAP-28(1–18): hemolytic activity significantly reduced (no specific concentration-hemolysis correspondence given, only mentioned as ""declined markedly""). 4. Modified form: mBMAP-28 (hydrophobic residues at C-terminus replaced with hydrophilic residues) 100 uM: only 3.3% hemolysis (much lower than parent BMAP-28's 94.1%). II. Hemolytic values for bovine red blood cells (species difference comparison) Bovine red blood cells are significantly less sensitive to BMAPs than human red blood cells: 1. BMAP-28 10 uM: 3% 30 uM: 6% 100 uM: 22% 2. BMAP-27 100 uM: virtually no hemolysis (""virtually unaffected""). III. Supplementary notes Hemolysis experiment conditions: 10% (v/v) red blood cell suspension in pH 7.4 PBS, incubated with peptides at 37 °C for 15 minutes, with complete hemolysis induced by 0.2% Triton X-100 as the 100% control. Trend: The hemolytic activity of peptides is mainly mediated by the hydrophobic domain at the C-terminus—removal (truncated forms) or modification (mBMAP-28) of this region significantly reduces hemolysis, but antibacterial activity (MIC) is largely retained.|||BMAP-28 can cause 14.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate exceeds 90% at 100 μM. BMAP-27 can cause 3.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate is 32.7% at 100 μM. Cow red blood cells are 5-10 times less sensitive to BMAP-28 than human red blood cells, with hemolysis rates of 3%, 6%, and 22% at concentrations of 10 μM, 30 μM, and 100 μM, respectively; BMAP-27 shows almost no hemolytic effect on cow red blood cells at 100 μM. The hemolytic effect of the truncated analog BMAP-27(1-18) disappears, and the hemolytic effect of BMAP-28(1-18) is greatly reduced. The modified analog mBMAP-28 has a hemolysis rate of only 3.3% for human red blood cells at 100 μM, far lower than the 94.1% of the parent peptide BMAP-28.|||BMAP-27 shows lower toxicity, with a hemolysis rate of only 3.5% at 3 uM and 32.7% at 100 uM.|||human RBC: HC50>100 uM (3.5% hemolysis at 3 uM; 32.7% hemolysis at 100 uM), but not hemo.lytic to bovine RBC even at 100 uM. Thus, hemolysis is related to cell sources, indicating the need of protecting the host from lysis." "Skerlavaj B., Gennaro R., Bagella L., Merluzzi L, Risso A, Zanetti M.1996 J. Biol. Chem. 1996; 271: 28375-28381. PubMed.||Xia et al., 2024|||J. Biol. Chem. 1996; 271: 28375-28381. PubMed.|||J Biol Chem . 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375.||Xia et al., 2024|||8910461, 29103679||Refer PubMed ID: 29103679|||J Biol Chem. 1996 Nov 8;271(45):28375-28381.|||8910461, 29103679||Refer PubMed ID: 29103679|||J. Biol. Chem. 1996; 271: 28375-28381. PubMed.||Xia et al., 2024" 27 FPDB00191 AP00367|||AP00367|||Cathelicidin-5 , Antibacterial peptide BMAP-28 , Myeloid antibacterial peptide 28|||DRAMO02854|||Cathelicidin-5 , Antibacterial peptide BMAP-28 , Myeloid antibacterial peptide 28|||AP00367 GGLRSLGRKILRAWKKYGPIIVPIIRIG Anti-E. coli ATCC 25922 ML-35 or D21, activity value is MIC = 0.5||Anti-S. typhimurium ATCC 14028, activity value is MIC = 1 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-S. marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-S. aureus ATCC 25923 or Cowan 1 MRSA, activity value is MIC = 1||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1 uM||Anti-B. megaterium Bm11, activity value is MIC = 1 uM||Anti-C. albicans, activity value is MIC = 8 uM||Anti-and C. neoformans, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Anti-MRSA||Hemolytic||Antibiofilm||Anticancer||Anti-E. coli ATCC 25922, activity value is MIC = 2 uM||Anti-E. coli ML35, activity value is MIC = 2 uM||Anti-E. coli D21, activity value is MIC = 0.5 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2 uM||Anti-S. aureus Cowan 1, activity value is MIC = 1 uM||Anti-S. aureus, activity value is MIC = 4 uM||Anti-B. megaterium Bm11, activity value is MIC = 2 uM||Anti-C. neoformans, activity value is MIC = 4 uM||Anti-E.coli(LOG 2, activity value is MIC = 5.80||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2 uM||Anti-Salmonella typhimurium ATCC 14028, activity value is MIC = 1 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-Serratia marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2 uM||Anti-Staphylococcus aureus Cowan 1, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 1 uM||Anti-Bacillus megaterium Bm11, activity value is MIC = 2 uM||Anti-Cryptococcus neoformans, activity value is MIC = 4 uM peripheral neutrophils; cattle, Bos taurus|||peripheral neutrophils; cattle, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine)|||Bos taurus [Bovine]|||peripheral neutrophils; cattle, Bos taurus Helix "The hemolytic activity of the two BMAPs was much lower, when measured on bovine erythrocytes (data not shown). These cells were 5–10-fold less susceptible than human red blood cells to BMAP-28 (3, 6, and 22% hemolysis at 10, 30, and 100000 uM peptide), and virtually unaffected by BMAP-27 even at 100000 uM. We speculate that the different susceptibility of human and bovine red blood cells to these molecules may be accounted for by species-specific differences in the erythrocyte membrane composition, and may reflect the need to protect the host cells from undesired cytotoxic effects. We have also noted that the effects of BMAP-28 on the cell membranes are consistently higher than BMAP-27, in spite of the structural similarity of the two molecules, thus suggesting that minor structural dif-ferences can modulate the activity of these peptides.|||The document explicitly mentions the hemolytic values of two novel antimicrobial peptides (BMAP-27, BMAP-28) and their derivatives (BMAP-27(1–18), BMAP-28(1–18), mBMAP-28) on human red blood cells. The core data are as follows: 1. Hemolytic properties of parent peptides (BMAP-27, BMAP-28). BMAP-28 (for human red blood cells): At a concentration of 3 μM, the hemolysis rate is 14.5%; At a concentration of 100 μM, the hemolysis rate exceeds 90% (specifically 94.1%). BMAP-27 (against human red blood cells): At a concentration of 3 μM, the hemolysis rate is only 3.5%; At a concentration of 100 μM, the hemolysis rate is 32.7%. Its hemolytic effect on bovine red blood cells is significantly lower than that of human red blood cells: BMAP-28 had hemolytic rates of 3%, 6%, and 22% at concentrations of 10 uM, 30 uM, and 100 uM, respectively; BMAP-27 has almost no hemolytic effect on bovine red blood cells even at a concentration of 100 uM. 2. Hemolytic properties of truncated derivatives (BMAP-27(1–18), BMAP-28(1–18)). The hemolytic effect of truncated peptides (retaining only 18 residues at the N-terminus and removing the hydrophobic tail at the C-terminus) is significantly reduced: BMAP-27 (1–18): Has almost no hemolytic activity against human red blood cells (Figure 6 shows no significant hemolytic rate; combined with text description of ""hemolytic effect disappears""). BMAP-28(1–18): hemolytic rate of human red blood cells is significantly lower than that of parent peptides (the curve in Figure 6 is close to baseline, no specific value, but the text clearly states ""hemolytic effect greatly reduced""). 3. Hemolytic properties of modified derivatives (mBMAP-28). Significant loss of hemolytic activity in mBMAP-28 (replacement of hydrophobic residues at the C-terminal for hydrophilic residues): At a concentration of 100 μM, the hemolytic rate for human red blood cells is only 3.3%, far lower than the 94.1% of the parent peptide BMAP-28. Additional notes Hemolysis detection method: Using standard hemolysis experiments, 10% (v/v) red blood cell suspension and peptides of different concentrations were incubated at 37°C for 15 minutes to measure absorbance at 415nm, using complete hemolysis induced by 0.2% Triton X-100 as a 100% control. Relationship between hemolysis and antibacterial activity: The hemolytic concentration of parental peptides (≥3 uM) is much higher than that of their antibacterial activity concentration (MIC: 0.25–4 uM); Truncated/modified derivatives retain antibacterial activity while significantly reducing hemolytic activity and improving targeted selectivity.|||The document clearly mentions the hemolytic values of BMAP-27, BMAP-28, and their analogues (truncated or modified forms) on human and bovine red blood cells. The core data are as follows: I. Hemolytic values for human red blood cells (key indicators) Measured by standard hemolysis experiments, presented as ""peptide concentration (uM) - hemolysis rate (%)"", the results are the average of multiple independent experiments (S.E. ≤1.8): 1. BMAP-28 3 uM: 14.5% 100 uM: >90% (specifically 94.1%) 2. BMAP-27 3 uM: 3.5% 100 uM: 32.7% 3. Truncated forms: BMAP-27(1–18), BMAP-28(1–18) BMAP-27(1–18): nearly no hemolytic activity (no specific value given, only mentioned as ""hemolytic effect disappeared""). BMAP-28(1–18): hemolytic activity significantly reduced (no specific concentration-hemolysis correspondence given, only mentioned as ""declined markedly""). 4. Modified form: mBMAP-28 (hydrophobic residues at C-terminus replaced with hydrophilic residues) 100 uM: only 3.3% hemolysis (much lower than parent BMAP-28's 94.1%). II. Hemolytic values for bovine red blood cells (species difference comparison) Bovine red blood cells are significantly less sensitive to BMAPs than human red blood cells: 1. BMAP-28 10 uM: 3% 30 uM: 6% 100 uM: 22% 2. BMAP-27 100 uM: virtually no hemolysis (""virtually unaffected""). III. Supplementary notes Hemolysis experiment conditions: 10% (v/v) red blood cell suspension in pH 7.4 PBS, incubated with peptides at 37 °C for 15 minutes, with complete hemolysis induced by 0.2% Triton X-100 as the 100% control. Trend: The hemolytic activity of peptides is mainly mediated by the hydrophobic domain at the C-terminus—removal (truncated forms) or modification (mBMAP-28) of this region significantly reduces hemolysis, but antibacterial activity (MIC) is largely retained.|||BMAP-28 can cause 14.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate exceeds 90% at 100 μM. BMAP-27 can cause 3.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate is 32.7% at 100 μM. Cow red blood cells are 5-10 times less sensitive to BMAP-28 than human red blood cells, with hemolysis rates of 3%, 6%, and 22% at concentrations of 10 μM, 30 μM, and 100 μM, respectively; BMAP-27 shows almost no hemolytic effect on cow red blood cells at 100 μM. The hemolytic effect of the truncated analog BMAP-27(1-18) disappears, and the hemolytic effect of BMAP-28(1-18) is greatly reduced. The modified analog mBMAP-28 has a hemolysis rate of only 3.3% for human red blood cells at 100 μM, far lower than the 94.1% of the parent peptide BMAP-28.|||At 3 uM, the hemolysis rate of BMAP-28 is 14.5%, and it exceeds 90% at 100 uM.|||The document mentions experimental results related to hemolysis, as follows: - Hemolytic effect of BMAP-28 on human red blood cells: at a concentration of 3 µM, 14.5% of cells were lysed; at 100 µM, more than 90% of cells were lysed. - Hemolytic effect of BMAP-27 on human red blood cells: at a concentration of 3 µM, 3.5% of cells were lysed; at 100 µM, 32.7% of cells were lysed. - Hemolytic effect of BMAP-28 on bovine red blood cells: at concentrations of 10 µM, 30 µM, and 100 µM, 3%, 6%, and 22% of cells were lysed, respectively. - Hemolytic effect of BMAP-27 on bovine red blood cells: even at a concentration of 100 µM, bovine red blood cells were almost unaffected. - Hemolytic effect of BMAP-28(1-18) on human red blood cells: hemolytic activity was significantly reduced (specific values were not clearly listed). - Hemolytic effect of BMAP-27(1-18) on human red blood cells: completely lost hemolytic activity. - Hemolytic effect of mBMAP-28 on human red blood cells: at a concentration of 100 µM, only 3.3% of cells were lysed.|||Human RBC: HC50 < 100 uM (at 100 uM, 90% hemolysis). However, lower hemolysis to bovine RBC BMAP-28 (3, 6, and 22% hemolysis at 10, 30, and 100000 uM peptide)." "Skerlavaj B., Gennaro R., Bagella L., Merluzzi L, Risso A, Zanetti M.1996 J. Biol. Chem. 1996; 271: 28375-28381. PubMed.|||J. Biol. Chem. 1996; 271: 28375-28381. PubMed.|||J Biol Chem . 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375.|||8910461, 29103679||Refer PubMed ID: 29103679|||J Biol Chem. 1996 Nov 8;271(45):28375-28381.|||8910461, 29103679||Refer PubMed ID: 29103679|||J. Biol. Chem. 1996; 271: 28375-28381. PubMed." 28 FPDB00194 AP00427|||AP00427|||XT-7|||DRAMP02136|||AP00427 GLLGPLLKIAAKVGSNLL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer||Anti-L. plantarum WCFS1, activity value is MIC = 128 ug/ml||Anti-L. rhamnosus LGG, activity value is MIC = 64 ug/ml||Anti-L. salivarius DSM20554, activity value is MIC = 128 ug/ml||Anti-L. salivarius FortaFit Ls-33, activity value is MIC = 250 ug/ml||Anti-L. casei R0215, activity value is MIC = 64 ug/ml||Anti-L. casei Shirota, activity value is MIC = 64 ug/ml||Anti-L. johnsonii LC-1, activity value is MIC = 128 ug/ml||Anti-L. reuteri ATCC5730, activity value is MIC = 64 ug/ml||Anti-L. acidophilus LA5, activity value is MIC = 64 ug/ml||Anti-S. suis S10, activity value is MIC = 32 ug/ml||Anti-S. aureus DMS20231, activity value is MIC = 16 ug/ml||Anti-S. aureus Sens 8325.4, activity value is MBC = 64 ug/ml||Anti-S. aureus MRSA B33424, activity value is MIC = 8 ug/ml||Anti-S. pseudintermedium E138, activity value is MIC = 8 ug/ml||Anti-S. pseudintermedium E139, activity value is MBC = 32 ug/ml||Anti-S. pseudintermedium E140, activity value is MBC = 16 ug/ml||Anti-S. pseudintermedium S70E2, activity value is MBC = 64 ug/ml||Anti-P. aeruginosa Sens 2 ATCC27853, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa MDR1 B38084, activity value is MIC = 256 ug/ml||Anti-P. aeruginosa MDR2 B31770, activity value is MIC = 32 ug/ml||Anti-E. faecium Sens S1, activity value is MIC = 256 ug/ml||Anti-E. faecium Sens S2, activity value is MIC = 64 ug/ml||Anti-E. faecium VanA R39, activity value is MIC = 8 ug/ml||Anti-E. faecium VanB R44, activity value is MIC = 16 ug/ml||Anti-A. baumannii MDR Bangl 027, activity value is MIC = 256 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 1.7 uM||Anti-S. aureus ATCC25923, activity value is MIC = 4.7 uM||Anti-E. coli ML35p, activity value is MIC = 3 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 25 uM||Anti-S. aureus multiresistant ATCCBAA-44, activity value is MIC = 1.6 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 6.3 uM||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-Escherichia coli, activity value is MIC = 5 uM||Anti-Candida albicans, activity value is MIC = 40 uM||Anti-Staphylococcus aureus, activity value is MIC = 7 uM||Anti-Staphylococcus epidermidis 1420129, activity value is MIC = 3 uM||Anti-S. saprophyticus 1950556, activity value is MIC = 13 uM||Anti-Escherichia coli 25922, activity value is MIC = 6 uM||Anti-Streptococcus group C 1541035, activity value is MIC = 3 uM||Anti-Shigella sonnei 1840187, activity value is MIC = 35 uM||Anti-Pseudomonas aeruginosa 0380972, activity value is MIC = 60 uM||Anti-Enterobacter cloacae 1441323, activity value is MIC = 35 uM Diploid clawed frog Silurana tropicalis, (formerly) Xenopus tropicalis , Africa|||Diploid clawed frog Silurana tropicalis, (formerly) Xenopus tropicalis , Africa|||Silurana tropicalis|||Xenopus tropicalis [Western clawed frog]|||Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)|||Diploid clawed frog Silurana tropicalis, (formerly) Xenopus tropicalis , Africa Helix "The abilities of the peptides isolated in this study to inhibit the growth of the Gram-positive bacterium S. aureus, the Gram-negative bacterium E. coli and the yeast C. albicans and to lyse human erythrocytes are compared in Table 1. The ability of a synthetic replicate of peptide XT-7 to inhibit the growth of a range of microorganisms from clinical isolates is shown in Table 2. The MIC values for the free acid form of XT-7 are 60 WM against E. coli, 130 WM against S. aureus and s 200 WM against C. albi-cans. The peptide showed no hemolytic activity at concentrations up to 400 WM. Synthetic des-Lys8- XT-7 was inactive against S. aureus and E. coli at concentrations up to 200 WM.|||The hemolytic data explicitly mentioned in the document (with 50% hemolysis concentration (HC₅₀) as the core indicator) are as follows, covering both natural peptides and synthetic analogs: 1. Natural antimicrobial peptides (XT-1 to XT-7) Hemolytic data are clearly recorded for only three peptides; the remaining peptides were either not tested (ND) or have no recorded hemolytic activity. Details are as follows: XT-1: HC₅₀ against human red blood cells not detected (ND). XT-7: HC₅₀ against human red blood cells = 70 μM, the only natural peptide with clearly noted hemolytic activity. XT-5, XT-6: HC₅₀ against human red blood cells both >150 μM, hemolytic activity is very weak. XT-2, XT-3, XT-4: No specific hemolytic values mentioned; it is inferred from antimicrobial activity tests that there is no significant hemolytic activity recorded. 2. Synthetic analogs of XT-7 By modifying the structure of XT-7 (reducing cationicity), its hemolytic activity changed significantly: XT-7 free acid (C-terminal -COOH replaced with -CONH₂): Even at concentrations up to 400 μM, no hemolytic activity was observed against human red blood cells. des-Lys⁸-XT-7 (lacking Lys⁸ residue): Specific HC₅₀ not mentioned, but since antimicrobial activity is completely lost (no activity against Staphylococcus aureus or E. coli at concentrations >200 μM), it is inferred that its hemolytic activity is also very low or absent. Note: All hemolytic experiments were conducted on human red blood cells, with HC₅₀ calculated by comparing to 100% hemolysis induced by 1% Tween 20 under incubation at 37 °C for 1 hour.|||Among the seven antimicrobial peptides secreted by the skin (XT-1 to XT-7), some peptides exhibit hemolytic activity against human erythrocytes. Their hemolytic values (HC₅₀, the peptide concentration causing 50% hemolysis) are as follows: - XT-1: 90 µM - XT-7: 70 µM - XT-2, XT-4, XT-5, XT-6: No hemolytic activity was observed at the tested concentrations (up to 150 µM or 400 µM), marked as "">153"" or not determined (ND).|||Rat RBCs [HC50 = 110 uM]|||In Biochimica et Biophysica Acta 2001, among the antimicrobial peptides isolated from the skin secretions of the tropical clawed frog (Xenopus tropicalis), XT-1 had an HC₅₀ of 90 μM against human red blood cells, XT-7 had an HC₅₀ of 70 μM against human red blood cells, the hemolytic activity of XT-2 was not measured, and XT-4, XT-5, and XT-6 all had an HC₅₀ greater than 150 μM against human red blood cells.|||HC₅₀=70" "ALI MF., SOTO A., KNOOP FC., CONLON JM.2001 Biochim Biophys Acta 2001 Nov 26;1550(1):81-9. PubMed.|||Biochim Biophys Acta 2001 Nov 26;1550(1):81-9. PubMed.|||Biochim Biophys Acta . 2001 Nov 26;1550(1):81-9. doi: 10.1016/s0167-4838(01)00272-2.|||31102497|||33932712, 23094651, 11738090||Refer PubMed ID 23094651|||Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.|||Biochim Biophys Acta 2001 Nov 26;1550(1):81-9. PubMed." 18 FPDB00195 AP00429|||AP00429|||Antimicrobial peptide NK-lysin|||DRAMP02980|||AP00429 GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||anti-sepsis||Antimalarial||Anticancer||Anti-Escherichia coli D21, activity value is MIC = 8 uM||Anti-Bacillus megaterium, activity value is MIC = 0.8 uM||Anti-moderate PIG Escherichia coli Bd2221/75, activity value is MIC = 39 uM||Anti-Streptococcus pyogeneis, activity value is MIC = 34 uM||Anti-Candida albicans, activity value is MIC = 31 uM||Anti-with medium E]: Escherichia coli D21, activity value is MIC = 0.5 uM||Anti-Escherichia coli Bd2221/75, activity value is MIC = 10 uM||Anti-Acinetobacter calcoaceticus Ac 11, activity value is MIC = 7 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 1.6 uM||Anti-Escherichia coli Bd2221/75, activity value is MIC = 39 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 0.8 uM||Anti-Streptococcus pyogenes w.t, activity value is MIC = 34 uM||Anti-Candida albicans w.t, activity value is MIC = 31 uM cytotoxic T and NK cells, small intestine, domestic pig Sus scrofa|||ytotoxic T and NK cells, small intestine, domestic pig Sus scrofa|||cytotoxic T and NK cells, small intestine, domestic pig Sus scrofa|||Sus scrofa [pig]|||Sus scrofa (Pig)|||cytotoxic T and NK cells, small intestine, domestic pig Sus scrofa Helix||Alpha helix 1 "Andersson M, Gunne H, Agerberth B, Boman A, Bergman T, Sillard R, Jörnvall H, Mutt V, Olsson B, Wigzell H, et al. 1995 EMBO J. 1995 Apr 18;14(8):1615-25. PubMed.|||1995 Apr 18;14(8):1615-25. doi: 10.1002/j.1460-2075.1995.tb07150.x.|||EMBO J . 1995 Apr 18;14(8):1615-25. doi: 10.1002/j.1460-2075.1995.tb07150.x.|||7737114|||EMBO J. 1995 Apr 18;14(8):1615-1625.|||EMBO J. 1995 Apr 18;14(8):1615-25. PubMed.|||EMBO J. 1995 Apr 18;14(8):1615-25. PubMed." 78 FPDB00200 AP00541|||AP00541|||CAMPSQ25 IDWKKLLDAAKQIL Anti-G+ and G- bacteria such as E. coli, activity value is MIC = 5 uM||Anti-S. aureus, activity value is MIC = 9 uM||Anti-and B. cereus, activity value is MIC = 5 uM||Anti-and P. aeruginosa, activity value is MIC = 5 uM||Anti-B. subtilis CCT 2576, activity value is MIC = 4 ug/ml||Anti-S. aureus ATCC 6538, activity value is MIC = 15 ug/ml||Anti-E. coli ATCC 25922, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa ATCC 15422, activity value is MIC = 8 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Chemotactic||Anticancer venom, social wasp, Polybia paulista|||venom, social wasp, Polybia paulista|||Vespa magnifica [Hornet]|||venom, social wasp, Polybia paulista, Brazil, Paraguay, and Argentina, South America Helix "Polybia-MPIpresented no hemolytic activity, while Polybia-CP presenteda very reduced hemolysis at 10−5000000 uM, but caused 78% hemol-ysis at the concentration of 10−4000000 uM.|||The document mentions the hemolytic activity results of two peptides: - Polybia-MPI: No hemolytic activity was observed within the experimental concentration range (up to 10^{-4} M). - Polybia-CP: Hemolytic activity was very low at 10^{-5} M, and at 10^{-4} M, it caused 78% hemolysis of red blood cells.|||It still exhibits no hemolytic activity at a concentration of 10⁻⁴ M." "Souza BM, Mendes MA, Santos LD, Marques MR, Cesar LM, Almeida RN, Pagnocca FC, Konno K, Palma MS2005 Peptides. 2005 Nov;26(11):2157-64. Pub-Med.||Wang K et al. 2014|||Peptides . 2005 Nov;26(11):2157-64. doi: 10.1016/j.peptides.2005.04.026. Epub 2005 Aug 29.||Wang K et al. 2014|||16129513|||Peptides. 2005 Nov;26(11):2157-64. Pub-Med.||Wang K et al. 2014|||Peptides. 2005 Nov;26(11):2157-64. Pub-Med." 14 FPDB00201 AP00565|||AP00565|||Brevinin-1DYe , Dybowskin-2|||Brevinin-1DYe , Dybowskin-2|||AP00565|||DRAMP01249 FLIGMTQGLICLITRKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||Anti-E.coli, activity value is MIC = 15 uM||Anti-S. aureus, activity value is MIC = 30 uM||Anti-Staphylococcus aureus, activity value is MIC = 15 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 25 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 50 ug/ml||Anti-Escherichia coli, activity value is MIC = 60 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 60 ug/ml||Anti-Candida albicans, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 3.3 uM||Anti-S. aureus, activity value is MIC = 7.9 uM||Anti-B. subtilis, activity value is MIC = 13.1 uM||Anti-S. epidermidis, activity value is MIC = 13.1 uM||Anti-S. dysenteriae, activity value is MIC = 26.2 uM||Anti-E. coli, activity value is MIC = 31.4 uM||Anti-K. pneumoniae, activity value is MIC = 31.4 uM||Anti-P.mirabilis, activity value is MIC > 100 ug/ml||Anti-P.aeruginosa, activity value is MIC > 100 ug/ml||Anti-and C. albicans, activity value is MIC = 100 ug/ml||Anti-S. lactis and E. coli, activity value is MIC = 12.8||Anti-Micrococcus luteus ATCC4698, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus KCTC3881, activity value is MIC = 15 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis ATCC12228, activity value is MIC = 25 ug/ml||Anti-Shigella dysenteriae ATCC9752, activity value is MIC = 50 ug/ml||Anti-Escherichia coli KCTC2433, activity value is MIC = 60 ug/ml||Anti-Klebsiella pneumoniae ATCC10031, activity value is MIC = 60 ug/ml||Anti-Proteus mirabilis ATCC25933, activity value is MIC > 100 ug/ml||Anti-Candida albicans ATCC36232, activity value is MIC = 100 ug/ml Rana dybowskii, Rana chensinensis, Asia|||Rana dybowskii, Rana chensinensis, Asia|||Rana dybowskii|||Rana dybowskii (Korea brown frog) N/A "Such a strong hydrophobic property may lead to indiscriminant membrane perturbation that would in turn explain its high hemolytic activity (47.58%).|||The document mentions content related to hemolysis. The specific hemolysis values are as follows: - Dybowskin-1: Hemolysis rate is 0.99%. - Dybowskin-2: Hemolysis rate is 10.99%. - Dybowskin-3: Hemolysis rate is 1.86%. - Dybowskin-4: Hemolysis rate is 47.58%. - Dybowskin-5: Hemolysis rate is 17.84%. - Dybowskin-6: Hemolysis rate is 59.40%.|||hRBC (10.99% hemolysis at 100 ug/ml)|||hRBC (10.99% hemolysis at 100 ug/ml)|||At the test concentration of 100 ug/ml, the hemolysis rate of Dybowskin-2 on human red blood cells is 10.99%.|||[Ref:17698251] It has 10.99% hemolytic activity at 100 ug/ml against human red blood cells|||Showed ~11% hemolysis at (100 ug/ml peptide to 10% human RBCs, v/v)." "Kim SS, et al. Lee BJ2007 Peptides 2007; 28: 1532-1539. PubMed|||Peptides . 2007 Aug;28(8):1532-9. doi: 10.1016/j.peptides.2007.07.002. Epub 2007 Jul 7.|||17688900 , 17698251||Refer PubMed ID: 17698251000000|||17688900 , 17698251||Refer PubMed ID: 17698251000000|||Peptides 2007; 28: 1532-1539. PubMed.||ref see AP605|||Ref.17698251|||Peptides 2007; 28: 1532-1539. PubMed." 17 FPDB00203 AP05186 FLKGLMGVIASLFK Anti-Gram+ S. aureus NCTC 13277 MRSA, activity value is MIC = 6.25 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 1.56 uM||Anti-S. typhi ATCC 14028, activity value is MIC = 50 uM||Anti-E. coli ATCC 25922, activity value is MIC = 25 uM||Anti-P. aeruginosa ATCC 10145, activity value is MIC = 50 uM||Anti-and fungi C. albicans ATCC 36082, activity value is MIC = 15.6 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer sequence extension, designed, man-made sequences Helix a hemolysis HC50 value of 90 uM|||NST-2(1): 90.0 uMRNST-2(2): 13.8 uMRSP-1(3): 51.0 uMRLFP-1(4): 98.9 uMRLFP-2(5): 25.0 uMRLFP-3(6): 6.6 uMRSP-4(7): >100 uMRLFP-4(8): 4.5 uM|||human RBC: HC50 51 uM. Hemolytic. Abdullah SJ, Guan JS, Mu Y, Bhattacharjya S.2024 Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213.|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed 14 FPDB00204 AP05185 FLKKLMGVIASLF Anti-Gram+ S. aureus NCTC 13277 MRSA, activity value is MIC = 50 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 12.5 uM||Anti-S. typhi ATCC 14028, activity value is MIC = 100 uM||Anti-E. coli ATCC 25922, activity value is MIC = 50 uM||Anti-P.aeruginosa ATCC 10145, activity value is MIC = 200 uM||Anti-and fungi C. albicans ATCC 36082, activity value is MIC = 100 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anticancer amino acid substitution, designed, man-made sequences Helix a hemolysis HC50 value of 90 uM|||NST-2(1): 90.0 uMRNST-2(2): 13.8 uMRSP-1(3): 51.0 uMRLFP-1(4): 98.9 uMRLFP-2(5): 25.0 uMRLFP-3(6): 6.6 uMRSP-4(7): >100 uMRLFP-4(8): 4.5 uM|||human RBC: HC50 >100 uM (not hemo.lytic at 100 uM). Abdullah SJ, Guan JS, Mu Y, Bhattacharjya S.2024 Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213.|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed 13 FPDB00205 AP05184 " FLKGLMGVIASLF" Anti-Gram+ S. aureus NCTC 13277 MRSA, activity value is MIC = 3.12 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 1.56 uM||Anti-S. typhi ATCC 14028, activity value is MIC = 50 uM||Anti-E. coli ATCC 25922, activity value is MIC = 50 uM||Anti-P.aeruginosa ATCC 10145, activity value is MIC = 200 uM||Anti-and fungi C. albicans ATCC 36082, activity value is MIC = 15.6 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer sequence reversal, designed, man-made sequences|||Source: sequence reversal, designed, man-made sequences Helix a hemolysis HC50 value of 90 uM|||NST-2(1): 90.0 uMRNST-2(2): 13.8 uMRSP-1(3): 51.0 uMRLFP-1(4): 98.9 uMRLFP-2(5): 25.0 uMRLFP-3(6): 6.6 uMRSP-4(7): >100 uMRLFP-4(8): 4.5 uM|||human RBC: HC50 13.8 uM; hemolytic. Abdullah SJ, Guan JS, Mu Y, Bhattacharjya S.2024 Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213.|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed 13 FPDB00206 AP05183 " FLSAIVGMLGKLF" Anti-Gram+ S. aureus NCTC 13277 MRSA, activity value is MIC = 14.34 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 6.25 uM||Anti-S.typhi ATCC 14028, activity value is MIC = 250 uM||Anti-E.coli ATCC 25922, activity value is MIC = 125 uM||Anti-P.aeruginosa ATCC 10145, activity value is MIC > 250 uM||Anti-and fungi C. albicans ATCC 36082, activity value is MIC = 20 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer amino acid substitution, amphibians, animal-derived, natural derivative Helix a hemolysis HC50 value of 90 uM|||NST-2(1): 90.0 uMRNST-2(2): 13.8 uMRSP-1(3): 51.0 uMRLFP-1(4): 98.9 uMRLFP-2(5): 25.0 uMRLFP-3(6): 6.6 uMRSP-4(7): >100 uMRLFP-4(8): 4.5 uM|||human RBC: HC50 90 uM. Nazir S, Khan AI, Maharjan R, Khan SN, Akram MA, Maresca M, Khan FA, Shaheen F. 2024 Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213.|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed|||Antibiotics (Basel). 2024 Dec 13;13(12):1213. doi: 10.3390/antibiotics13121213. PubMed 13 FPDB00212 AP04839|||DRAMP32284 ALWKDMLKGIGKLAGKAALGAVKTLV Anti-S. aureus NCTC 10788or MRSA NCTC 12493, activity value is MIC = 2 uM||Anti-E. faecalis NCTC 1269, activity value is MIC = 4 uM||Anti-E. coli NCTC 10418, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 2 uM||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 1 uM||Anti-MCF-7, activity value is IC50 = 2.92 uM||Anti-PC-3, activity value is IC50 = 4.15 uM||Anti-and U251 MG cells, activity value is IC50 = 2.47 uM||Antimicrobial||Anticancer Phyllomedusa palliata, South America|||Phyllomedusa palliata Skin Secretions|||Phyllomedusa palliata Skin Secretions Helix Hemolysis concentration for 50% (HC₅₀): 38.77 uM Hemolysis rate at 16 uM concentration: <20%|||horse RBC: HC50 38.77 uM. Induced a very low degree of LDH release in normal HMEC-1 cells (<10%).|||Horse erythrocytes: Dermaseptin-PP exhibited only a moderate hemolytic effect (<20% at 16 uM with a calculated HC50 of 38.77 uM)|||horse RBC: HC50 38.77 uM. Dong Z, Hu H, Yu X, Tan L, Ma C, Xi X, Li L, Wang L, Zhou M, Chen T, Du S, Lu Y.2020Front Chem. 2020 Jun 5;8:476. doi: 10.3389/fchem.2020.00476. PubMed|||2020 Jun 5:8:476. doi: 10.3389/fchem.2020.00476. eCollection 2020.|||Front Chem. 2020 Jun 5;8:476. doi: 10.3389/fchem.2020.00476. PubMed|||J Biol Chem. 2020 Aug 7;295(32):10911-10925.|||Front Chem. 2020 Jun 5;8:476.|||Front Chem. 2020 Jun 5;8:476. doi: 10.3389/fchem.2020.00476. PubMed 26 FPDB00213 AP04836 " FFPKVAGVAAKVLKKFCTISKKC" Anti-S. aureus NCTC 6538, activity value is MIC = 32 uM||Anti-493, activity value is MIC > 128 uM||Anti-697, activity value is MIC = 64 uM||Anti-E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-816, activity value is MIC = 4 uM||Anti-P. aeruginosa ATCC CRM 9027, activity value is MIC = 16 uM||Anti-A. baumannii BAA 747, activity value is MIC = 16 uM||Anti-231, activity value is MIC = 16 uM amino acid substitution, amino acid deletion, amphibians, animal-derived, natural derivative Helix horse RBC: HC50 >128 uM, less hemo.lytic. Less toxic to HaCaT skin cells (IC50 128.1 uM). Also showed effects on both H838 (IC50 4.54 uM) and MCF-7 (IC50 7.19 uM) cancer cell lines.|||horse RBC: HC50 >128 uM, less hemo.lytic. Wang J, Hu J, Pu W, Chen X, Ma C, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, Wang L. 2024 Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed|||Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed|||Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed 23 FPDB00215 AP04819 " FLSLIPKAIKAVKALAKKL" Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 2 uM||Anti-E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-A. baumannii BAA 747, activity value is MIC = 2 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 16 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anticancer amino acid substitution, amphibian peptide analog, animal-derived, natural derivative Helix PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||In vitro toxicity: horse RBC: HC50 32 uM. It showed toxicity to both cancer and non-cancer cells.|||w90c6t7w1sexseowqbf1|||horse RBC: HC50 32 uM. It showed toxicity to both cancer and non-cancer cells. Yin W, Yao J, Leng X, Ma C, Chen X, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, et al. 2024 Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI 19 FPDB00216 AP04818|||AP04818|||AP04819 " FLSLIPKAIKAVSALAKKL" Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 2 uM||Anti-E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-A. baumannii BAA 747, activity value is MIC = 4 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 16 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-A. baumannii BAA 747, activity value is MIC = 2 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anticancer amino acid substitution, amphibian peptide analog, animal-derived, natural derivative Helix PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||horse RBC: HC50 64 uM. It showed toxicity to both cancer and non-cancer cells.|||w90c6t7w1sexseowqbf1 Yin W, Yao J, Leng X, Ma C, Chen X, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, et al. 2024 Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098.|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI 19 FPDB00217 AP04815 " FLSLIPHAISAVSALAKHL" Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 2||Anti-E. coli ATCC 8739, activity value is MIC = 16 uM||Anti-A.baumannii BAA 747, activity value is MIC > 128 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 64 uM||Anti-P.aeruginosa ATCC 9027, activity value is MIC > 128 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anticancer the skin secretion, Super Tiger Leg Monkey Tree Frog, Phyllomedusa tomopterna, Central America, South America|||the skin secretion, Super Tiger Leg Monkey Tree Frog, Phyllomedusa tomopterna, Central America, South America Helix PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||horse RBC: HC50 64 uM.|||w90c6t7w1sexseowqbf1 Yin W, Yao J, Leng X, Ma C, Chen X, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, et al. 2024 Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI 19 FPDB00218 AP04729|||AP04729|||AaeAP1a|||DRAMP21253|||AaeAP1a|||DRAMP21253 " FLFKLIPKAIKGLVKAIRK" Anti-S. aurerus, activity value is MIC = 4 ug/ml||Anti-E.coli, activity value is MIC = 16 ug/ml||Anti-and C. albicans, activity value is MIC = 4 ug/ml||Antibacterial||Antifungal ; Androctonus aeneas||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-E. coli, activity value is MIC = 16 ug/ml||Anti-C. albicans S, activity value is MIC = 4 ug/ml||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||activity value is MBC = 32 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 16 ug/ml||Anti-##Fungi : Candida albicans, activity value is MIC = 4 ug/ml||activity value is MBC = 16 ug/ml amino acid substitution, scorpions, animal-derived, natural derivative|||amino acid substitution, scorpions, animal-derived, natural derivative|||Androctonus aeneas|||Synthetic construct N/A horse RBC: 100% hemolysis at 64 ug/ml.|||S. aureus (MIC= 4 ug/ml), E. coli (MIC= 16 ug/ml), C. albicans S (MIC= 4 ug/ml)||Horse RBCs ( 100% hemolysis at 32 ug/ml)|||Horse RBCs ( 100% hemolysis at 32 ug/ml)|||Horse RBCs ( 100% hemolysis at 32 ug/ml)|||[Ref.25626077] 100% hemolysis at 32 ug/ml against horse red blood cells|||horse RBC: 100% hemolysis at 64 ug/ml. Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C. 2015 Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed|||https://pubmed.ncbi.nlm.nih.gov/25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.||Ref.25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed 19 FPDB00219 AP04728|||AP04728|||AaeAP2a|||DRAMP21254|||AaeAP2a|||DRAMP21254 " FLFKLIPKVIKGLVKAIRK" Anti-S. aurerus, activity value is MIC = 4 ug/ml||Anti-E.coli, activity value is MIC = 16 ug/ml||Anti-and C. albicans, activity value is MIC = 4 ug/ml||Antibacterial||Antifungal ; Androctonus aeneas||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-E. coli, activity value is MIC = 16 ug/ml||Anti-C. albicans S, activity value is MIC = 4 ug/ml||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||activity value is MBC = 32 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 16 ug/ml||Anti-##Fungi : Candida albicans, activity value is MIC = 4 ug/ml||activity value is MBC = 16 ug/ml amino acid substitution, scorpions, animal-derived, natural derivative|||amino acid substitution, scorpions, animal-derived, natural derivative|||Androctonus aeneas|||Synthetic construct N/A horse RBC: 100% hemolysis at 32 ug/ml.|||S. aureus (MIC= 4 ug/ml), E. coli (MIC= 16 ug/ml), C. albicans S (MIC= 4 ug/ml)||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||[Ref.25626077] 100% hemolysis at 64 ug/ml against horse red blood cells|||horse RBC: 100% hemolysis at 32 ug/ml. Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C. 2015 Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed|||https://pubmed.ncbi.nlm.nih.gov/25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.||Ref.25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219. PubMed 19 FPDB00221 AP04623 " ALWKTLLKHVGKAAGKAALNAVTDMVNQ" Anti-S. aureus ATCC 12600 MRSA ATCC BAA-1720, activity value is MIC = 4||Anti-E. faecalis ATCC 29212, activity value is MIC = 32 uM||Anti-E. coli ATCC 11755, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 16 uM||Anti-and C. albicans ATCC 10231, activity value is MIC = 4 uM skin secretion, Painted-belly leaf frog, Phyllomedusa sauvagii, South America|||skin secretion, Painted-belly leaf frog, Phyllomedusa sauvagii, South America Helix Der-PS4 exhibited approximately 50% hemolytic activity at a concentration of about 128 μM. At the minimum inhibitory concentrations (MICs), Der-PS4 showed slight hemolytic activity.|||horse RBC: HC50 ~128 uM. It started to show hemolysis at 16 uM. Chen D, Zhou X, Chen X, Huang L, Xi X, Ma C, Zhou M, Wang L, Chen T.2019 Molecules. 2019 Aug 16;24(16):2974. doi: 10.3390/molecules24162974. PubMed|||2019 Aug 16;24(16):2974. doi: 10.3390/molecules24162974.|||Molecules. 2019 Aug 16;24(16):2974. doi: 10.3390/molecules24162974. PubMed|||Molecules. 2019 Aug 16;24(16):2974. doi: 10.3390/molecules24162974. PubMed 28 FPDB00222 AP04526|||Stigmurin|||DRAMP20958|||Stigmurin|||DRAMP20958 " FFKLIPKLVKGLISAFK" Anti-Gram- E. coli ATCC 25922, activity value is MIC = 2.34 uM||Anti-E. cloacae ATCC 13047, activity value is MIC = 9.38 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1.17 uM||Anti-S. aureus ATCC 29213, activity value is MIC = 2.34 uM||Anti-S. epidermidis ATCC 122225, activity value is MIC = 9.38 uM||Anti-E. faecalis ATCC 4028, activity value is MIC = 1.17 uM||Anti-s C. albicans ATCC 90028, activity value is MIC = 4.69 uM||Anti-C. krusei ATCC 6258, activity value is MIC = 9.38 uM||Anti-and C. glabrata ATCC 90030, activity value is MIC = 9.38 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.34 uM||Anti-P. aeuruginosa, activity value is MIC = 1.17 uM||Anti-E. cloacae, activity value is MIC = 9.38 uM||Anti-S. aureus, activity value is MIC = 2.34 uM||Anti-S. epidermidis, activity value is MIC = 9.38 uM||Anti-E. faecalis, activity value is MIC = 1.17 uM||Anti-C. albicans, activity value is MIC = 4.69 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 2.34 uM||Anti-Staphylococcus epidermidis ATCC 122225, activity value is MIC = 9.38 uM||Anti-Enterococcus faecalis ATCC 4028, activity value is MIC = 1.17 uM||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 9.38 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1.17 uM||Anti-s: Candida albicans ATCC 90028, activity value is MIC = 4.69 uM||Anti-Candida krusei ATCC 6258, activity value is MIC = 9.38 uM||Anti-Candida glabrata ATCC 90030, activity value is MIC = 9.38 uM||Anti-HeLa cell line, activity value is IC50 = 13.01 uM||Anti-##Gram-negative bacteria: Escherichia coli ATCC 25922, activity value is MIC = 2.34 uM||Anti-##yeasts: Candida albicans ATCC 90028, activity value is MIC = 4.69 uM||Anti-##HeLa cell line, activity value is IC50 = 13.01 uM amino acid substitution, amino acid truncation, animal-derived, natural derivative|||Synthetic construct|||amino acid substitution, sequence truncation, animal-derived, natural derivative Helix||Alpha helix "approximately 30% hemolysis at 75000000 uM.|||Human RBC (30% hemolysis at 75 uM)|||- Test subjects: Healthy human O⁺ red blood cells, incubated at 37°C for 1 hour, detection wavelength 540 nm; negative control (PBS only) showed 0% hemolysis, positive control (Triton-X) showed 100% hemolysis. - Natural peptide Stigmurin: Low hemolytic activity in the concentration range of 1.17–75 µM, with a hemolysis rate of only 3% at the highest concentration (75 µM). - Analogs StigA6 and StigA16: Hemolysis rate around 30% at the highest concentration (75 µM); however, at lower concentrations that exhibit antibacterial and antiproliferative activity (corresponding to MIC and effective concentrations), hemolysis rate is below 10%, indicating minimal toxicity. - Key correlation: Increased hemolytic activity of the analogs is associated with the hydrophobic moment increase caused by lysine substitution, but hemolytic activity remains low at lower concentrations, not significantly affecting biosafety.|||Human RBC (30% hemolysis at 75 uM)|||[Ref.29670004] Hemolysis 0% at 1.17 [Ref.29670004] Hemolysis 0% at 1.17 uM, hemolysis 2% at 2.34 uM, hemolysis 10% at 4.69 uM, hemolysis 20% at 9.38 uM, hemolysis 35% at 18.75 uM, hemolysis 37% at 37.5 uM, hemolysis 40% at 75 uM against human red blood cells|||human RBC: low levels (<50%) of hemolysis until 75 uM, while the parent peptide showed no hemolysis under the same condition. Updated: seq corrected 10/2024" Parente AMS, Daniele-Silva A, Furtado AA, Melo MA, Lacerda AF, Queiroz M, Moreno C, Santos E, Rocha HAO, Barbosa EG, Carvalho E, Silva-Júnior AA, Silva MS, Fernandes-Pedrosa MF.2018 Toxins (Basel). 2018 Apr 18;10(4):161. doi: 10.3390/toxins10040161. PubMed|||29670004|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||29670004|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||Toxins (Basel). 2018 Apr 18;10(4):161. doi: 10.3390/toxins10040161. PubMed 17 FPDB00223 AP04525|||Stigmurin|||DRAMP20957|||Stigmurin|||DRAMP20957 FFSLIPKLVKGLISAFK Anti-Gram- E. coli ATCC 25922, activity value is MIC = 4.69 uM||Anti-E. cloacae ATCC 13047, activity value is MIC = 18.75 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 9.38 uM||Anti-S. aureus ATCC 29213, activity value is MIC = 2.34 uM||Anti-S. epidermidis ATCC 122225, activity value is MIC = 1.17 uM||Anti-E. faecalis ATCC 4028, activity value is MIC = 1.17 uM||Anti-s C. albicans ATCC 90028, activity value is MIC = 9.38 uM||Anti-C. krusei ATCC 6258, activity value is MIC = 37.5 uM||Anti-and C. glabrata ATCC 90030, activity value is MIC = 17.75 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 4.69 uM||Anti-P. aeuruginosa, activity value is MIC = 9.38 uM||Anti-E. cloacae, activity value is MIC = 18.75 uM||Anti-S. aureus, activity value is MIC = 2.34 uM||Anti-S. epidermidis, activity value is MIC = 1.17 uM||Anti-E. faecalis, activity value is MIC = 1.17 uM||Anti-C. albicans, activity value is MIC = 9.38 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 2.34 uM||Anti-Staphylococcus epidermidis ATCC 122225, activity value is MIC = 9.38 uM||Anti-Enterococcus faecalis ATCC 4028, activity value is MIC = 1.17 uM||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 18.75 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 9.38 uM||Anti-s: Candida albicans ATCC 90028, activity value is MIC = 9.38 uM||Anti-Candida krusei ATCC 6258, activity value is MIC = 37.5 uM||Anti-Candida glabrata ATCC 90030, activity value is MIC = 18.75 uM||Anti-HeLa cell line, activity value is IC50 = 14.01 uM||Anti-##Gram-negative bacteria: Escherichia coli ATCC 25922, activity value is MIC = 4.69 uM||Anti-##yeasts: Candida albicans ATCC 90028, activity value is MIC = 9.38 uM||Anti-##HeLa cell line, activity value is IC50 = 14.01 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct Helix||Alpha helix "approximately 30% hemolysis at 75000000 uM.|||Human RBC (40% hemolysis at 75 uM)|||- Test subjects: Healthy human O⁺ red blood cells, incubated at 37°C for 1 hour, detection wavelength 540 nm; negative control (PBS only) showed 0% hemolysis, positive control (Triton-X) showed 100% hemolysis. - Natural peptide Stigmurin: Low hemolytic activity in the concentration range of 1.17–75 µM, with a hemolysis rate of only 3% at the highest concentration (75 µM). - Analogs StigA6 and StigA16: Hemolysis rate around 30% at the highest concentration (75 µM); however, at lower concentrations that exhibit antibacterial and antiproliferative activity (corresponding to MIC and effective concentrations), hemolysis rate is below 10%, indicating minimal toxicity. - Key correlation: Increased hemolytic activity of the analogs is associated with the hydrophobic moment increase caused by lysine substitution, but hemolytic activity remains low at lower concentrations, not significantly affecting biosafety.|||Human RBC (40% hemolysis at 75 uM)|||[Ref.29670004] Hemolysis 0% at 1.17 uM, hemolysis 2% at 2.34 uM, hemolysis 15% at 4.69 uM, hemolysis 27% at 9.38 uM, hemolysis 30% at 18.75 uM, hemolysis 30% at 37.5 uM, hemolysis 27% at 75 uM against human red blood cells|||human RBC: low levels (<50%) of hemolysis until 75 uM, while the parent peptide showed no hemolysis under the same condition." Parente AMS, Daniele-Silva A, Furtado AA, Melo MA, Lacerda AF, Queiroz M, Moreno C, Santos E, Rocha HAO, Barbosa EG, Carvalho E, Silva-Júnior AA, Silva MS, Fernandes-Pedrosa MF.2018 Toxins (Basel). 2018 Apr 18;10(4):161. doi: 10.3390/toxins10040161. PubMed|||29670004|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||29670004|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||Toxins (Basel). 2018 Apr 18;10(4):161. doi: 10.3390/toxins10040161. PubMed 17 FPDB00230 AP04035|||AP04035|||CAMPSQ23276|||DRAMP29124 LNLKKLLKVAKKIL Anti-Gram+ S. aureus ATCC 25923, activity value is MIC = 32 uM||Anti-B. cereus ATCC 11778, activity value is MIC = 16 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 4 uM||Anti-L. monocytogenes ATCC 15313, activity value is MIC = 4 uM||Anti-E. coli ATCC 25922, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 64 uM||Anti-S. enterica ATCC 13076, activity value is MIC = 32 uM||Anti-and fungi C. albicans ATCC 10231, activity value is MIC = 16 uM||LNLKKLLKVAKKIL||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 16 uM||Anti-Bacillus subtilis ATCC 23857, activity value is MIC = 4 uM||Anti-##Gram-negative bacteria:Escherichia coli ATCC 25922, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 4 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 8 uM||Anti-H1975, activity value is IC50 = 6.25012||Anti-and H441, activity value is IC50 = 3.1 Amino acid substitution|||Amino acid substitution|||Synthetic construct|||Synthetic construct Alpha helix,random coil human RBC, HC50 128 uM, less hemo.lytic.|||Mouse erythrocytes (15% Hemolysis at 256 uM|||human RBC, HC50 128 uM, less hemo.lytic.|||[Ref.33285267]15% hemolysis against mouse erythrocytes at 256 uM. Thi Phuong HB, Huy BL, Van KN, Thi ND, Thi TB, Thi Hai YN, Thanh TB, Xuan HL, Thi Thanh BN. 2023 ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed|||ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed|||33285267|||ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed|||Eur J Pharm Sci. 2021 Mar 1;158:105665.||Ref.33285267|||ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed 14 FPDB00237 AP03631|||AP03631|||K2-CRAMP18|||DRAMP33028 GKKLKKIGQKIKNFFQKL Anti-CRAMP-18 E2K is active against E. coli KCTC 1682, activity value is MIC = 3.12 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 1.56 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 0.78 uM||Anti-B. subtilis KCTC 1918, activity value is MIC = 3.12 uM||Anti-S. pyogenes KCTC 3096, activity value is MIC = 3.12 uM||Anti-S. aureus KCTC 1621, activity value is MIC = 1.56 uM||Anti-C. albicans, activity value is MIC = 6.25 uM||Anti-A. fumigatus, activity value is MIC = 12.5 uM||Anti-tumor cells: A549, activity value is IC50 = 25 uM||Anti-K562, activity value is IC50 = 34 uM||Anti-Jurkat, activity value is IC50 = 20 uM||Antimicrobial||Anticancer amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic (Derived from CRAMP-18) Helix 2.2% hemolysis at a concentration of 100000 uM|||amino acid substitution, cathelicidin analog, animal-derived, natural derivative||No hemolytic activity.|||0% hemolysis at 100 uM (not hemo.lytic).|||No hemolytic activity.|||0% hemolysis at 100 uM (not hemo.lytic).|||0% hemolysis at 100 uM (not hemo.lytic). Shin SY, Kang SW, Lee DG, Eom SH, Song WK, Kim JI. 2000 Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med. 18 FPDB00238 AP03630|||AP03630|||MCRAMP GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ Anti-E. coli, activity value is MIC = 3.12 uM||Anti-S. typhimurium, activity value is MIC = 3.12 uM||Anti-P. aeruginosa, activity value is MIC = 3.12 uM||Anti-B. subtilis, activity value is MIC = 6.25 uM||Anti-S. pyogenes, activity value is MIC = 6.25 uM||Anti-S. aureus, activity value is MIC = 3.12 uM||Anti-C. albicans, activity value is MIC = 12||Anti-A. fumigatus, activity value is MIC = 12.5 uM||Anti-tumor cells: A549, activity value is IC50 = 22 uM||Anti-K562, activity value is IC50 = 28 uM||Anti-Jurkat, activity value is IC50 = 16 uM||Antibacterial||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibiofilm||Anticancer bone marrow, saliva, Mice, Mus musculus|||bone marrow, saliva, Mice, Mus musculus|||Mus musculus [Mouse]|||bone marrow, saliva, Mice, Mus musculus N/A bone marrow, saliva, Mice, Mus musculus|||2.2% hemolysis at 100 uM (hemo.lytic) (Data from ref for AP3628. This peptide differs from the natural form only by the last Q, which is neutral presumably with a minimal effect on activity).|||2.2% hemolysis at 100 uM (hemo.lytic) (Data from ref for AP3628. This peptide differs from the natural form only by the last Q, which is neutral presumably with a minimal effect on activity).|||2.2% hemolysis at 100 uM (hemo.lytic) (Data from ref for AP3628. This peptide differs from the natural form only by the last Q, which is neutral presumably with a minimal effect on activity). UPdated 10/2023 Pestonjamasp VK, Huttner KH, Gallo RL.2001 Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.||Wang et al., 2023|||Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.||Wang et al., 2023|||Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.||Wang et al., 2023|||11557478|||Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.|||Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.||Wang et al., 2023|||Peptides. 2001 Oct;22(10):1643-50. doi: 10.1016/s0196-9781(01)00499-5. Pub-Med.||Wang et al., 2023 34 FPDB00246 AP03425|||DRAMP35857 GLLGKILGAGKKVLCGVSGLC Anti-788, activity value is MIC = 4 uM||Anti-923, activity value is MIC = 16 uM||Anti-MRSA B042 V2E1A, activity value is MIC = 16||Anti-697, activity value is MIC = 8 uM||Anti-S. constellatus B003 VISIT, activity value is MIC = 8 uM||Anti-418, activity value is MIC = 8 uM||Anti-816, activity value is MIC = 16 uM||Anti-P. aeruginosa ATCC 9097, activity value is MIC = 64 uM||Anti-P. aeruginosa B004 V2S2B, activity value is MIC = 16 uM||Anti-and fungus C. albicans NYCY 1467, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Antimicrobial Pelophylax nigromaculatus, Asia|||Animalia Helix Pelophylax nigromaculatus, Asia Chengyu Lu, Lingling Liu, Chengbang Ma, Liuqing Di, Tianbao Chen 2022 Journal of Genetic Engineering and Biotechnology 2022; 20:76. Publisher Web|||Journal of Genetic Engineering and Biotechnology 2022; 20:76. Publisher Web|||J Genet Eng Biotechnol. 2022 May 23;20(1):76.|||Journal of Genetic Engineering and Biotechnology 2022; 20:76. Publisher Web 21 FPDB00248 AP03307|||AP03307|||T-DPH1|||T-DPH1|||AP03307|||DRAMP35817 GLWSKIKNVAAAAGKAALGAL Anti-S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 8||Anti-E.faecalis NCTC 12697, activity value is MIC = 128 uM||Anti-E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 16 uM||Anti-C. albicans ATCC 10231, activity value is MIC = 64 uM||Anti-H157 and U251MG, activity value is IC50 = 10.2||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Anti-S. aureus ATCC 6538, activity value is MIC = 8 uM||Anti-Methicillin-resistant Staphylococcus aureus NCTC 12493, activity value is MIC = 16 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MIC = 128 uM||Antimicrobial skin secretion, the northern orange-legged leaf frog, tiger-legged monkey frog, Phyllomedusa hypochondrialis, South America|||Phyllomedusa hypochondrialis [orange-legged leaf frog]|||Animalia|||skin secretion, the northern orange-legged leaf frog, tiger-legged monkey frog, Phyllomedusa hypochondrialis, South America Helix "skin secretion, the northern orange-legged leaf frog, tiger-legged monkey frog, Phyllomedusa hypochondrialis, South America|||Horse RBC [HC50= 106.4 uM]|||The key value related to hemolysis in this study is the half-maximal hemolytic concentration (HC₅₀), with horse red blood cells as the test subject. The specific data are as follows: The parent peptide t-DPH1 has an HC₅₀ of 106.4 μM, and its hemolysis rate exceeds 50% at a high concentration (100 μM); Analogue t-DPH1-K4 has an HC₅₀ of 444.8 μM, which is 4 times that of the parent peptide; Analogue t-DPH1-5K has an HC₅₀ of 19.39 μM, and is the only analogue with increased hemolytic activity, approximately 5 times that of the parent peptide, with a hemolysis rate approaching 40% at 10 μM concentration; Analogue t-DPH1-6K has an HC₅₀ of 834.6 μM, 8 times that of the parent peptide; Analogue t-DPH1-6KW has an HC₅₀ of 2094 μM, showing the lowest hemolytic activity, with almost no hemolysis observed at the tested concentrations. Except for t-DPH1-5K, all other designed analogues have lower hemolytic activity than the parent peptide at the tested concentrations.|||Horse RBC [HC50= 106.4 uM]" "Qin H, Fang H, Chen X, Wang L, Ma C, Xi X, Chen T, Shaw C, Zhou M. 2021 Antibiotics (Basel). 2021 Dec 14;10(12):1529. doi: 10.3390/antibiotics10121529. PubMed|||Microb Genom . 2017 Sep 25;3(10):e000134. doi: 10.1099/mgen.0.000134. eCollection 2017 Oct.|||Microb Genom . 2017 Sep 25;3(10):e000134. doi: 10.1099/mgen.0.000134. eCollection 2017 Oct.|||34943741|||Antibiotics (Basel). 2021 Dec 14;10(12):1529. doi: 10.3390/antibiotics10121529. PubMed|||34943741|||Microb Genom . 2017 Sep 25;3(10):e000134. doi: 10.1099/mgen.0.000134. eCollection 2017 Oct.|||Antibiotics (Basel). 2021 Dec 14;10(12):1529.|||Antibiotics (Basel). 2021 Dec 14;10(12):1529. doi: 10.3390/antibiotics10121529. PubMed" 21 FPDB00252 AP03279|||AP03279|||Pituitary adenylate cyclase-activating polypeptide, PACAP-38|||Pituitary adenylate cyclase-activating polypeptide, PACAP-38|||AP03279|||DRAMP32144 HSDGIFTDSYSRYRKQMAVKKYLAAVLGRRYRQRFRNK Anti-fish Gram- pathogens Y. ruckeri, activity value is MIC = 50 uM||Anti-A. salmonicida, activity value is MIC = 50 uM||Anti-human bacteria B. subtilis, activity value is MIC = 5 uM||Anti-and C. albicans, activity value is MIC = 75 uM||Anti-S.aureus, activity value is MIC > 300 uM||Anti-P.aeruginosa, activity value is MIC = 300 uM||Anti-E.coli, activity value is MIC > 300 uM||Anti-and Salmonella sp, activity value is MIC = 300 uM||Antibacterial||Antifungal||Anti-Yersinia ruckeri 4319/03, activity value is MIC = 50 uM||Anti-Yersinia ruckeri 4319/03, activity value is IC50 = 0.023 uM||Anti-Aeromonas hydrophila 4387/12, activity value is MIC = 300 uM||Anti-Aeromonas hydrophila 4387/12, activity value is IC50 = 7.2 uM||Anti-Aeromonas sobria 02/12, activity value is MIC = 100 uM||Anti-Aeromonas sobria 02/12, activity value is IC50 = 28.6 uM||Anti-Aeromonas salmonicida 4387/12, activity value is MIC = 50 uM||Anti-Bacillus subtilis ATCC 6333, activity value is MIC = 5 uM||Anti-Bacillus subtilis ATCC 6333, activity value is IC50 = 0.76 uM||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC > 300 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 300 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is IC50 = 54.4 uM||Anti-Escherichia coli ATCC 8739, activity value is MIC > 300 uM||Anti-Escherichia coli ATCC 8739, activity value is IC50 = 46.6 uM||Anti-Salmonella sp, activity value is MIC = 300 uM||Anti-Salmonella sp, activity value is IC50 = 116.8 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 75 uM||Anti-Candida albicans ATCC 10231, activity value is IC50 = 36.9 uM||Anti-Human lung carcinoma NCI-H460, activity value is IC50 = 14.97||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||candidacidal Clarias gariepinus, North Africa|||Clarias gariepinus|||Clarias gariepinus|||Clarias gariepinus, North Africa|||Synthetic N/A Clarias gariepinus, North Africa|||Human erythrocytes (0% Hemolysis at <75 uM|||Human erythrocytes (0% Hemolysis at <75 uM|||Human red blood cells: PACAP was not hemolytic for human erythrocytes at concentrations below 75 uM (0% hemolysis). At concentration between 75 uM and 150 uM the hemolytic activity was less than 3%; Fish red blood cells:PACAP was not hemolytic for fish red blood cells at concentrations below 18.75 uM (0% hemolysis). At concentration between 18.75 uM and 150 uM, the hemolytic activity was less than 20%|||Interestingly, catfish PACAP was less cytotoxic for human cells than for fish cells. In any case, the hemolytic activity reached 50% hemolysis (Fig. 4A and B). PACAP was not hemolytic for fish red blood cells at concentrations below 18.75 uM (0% hemolysis). At concentration between 18.75 uM and 150 uM, the hemolytic activity was less than 20%. PACAP reached a top value of 39% hemolysis at the highest concentration analyzed (300 uM) (Fig. 4A). On the other hand, PACAP was not hemolytic for human erythrocytes at concentrations below 75 uM (0% hemolysis). At concentration between 75 uM and 150 uM the hemolytic activity was less than 3%. PACAP reached a top value of 6% hemolysis at the highest concentration analyzed (300 uM) (Fig. 4B). "Lugo JM, Tafalla C, Oliva A, Pons T, Oliva B, Aquilino C, Morales R, Estrada MP. 2018 Fish Shellfish Immunol. 2019 Mar;86:559-570. doi: 10.1016/j.fsi.2018.11.056. PubMed|||Fish Shellfish Immunol . 2019 Mar:86:559-570. doi: 10.1016/j.fsi.2018.11.056. Epub 2018 Nov 24.|||30481557|||30481557|||Fish Shellfish Immunol . 2019 Mar:86:559-570. doi: 10.1016/j.fsi.2018.11.056. Epub 2018 Nov 24.|||Fish Shellfish Immunol. 2019 Mar;86:559-570.|||Fish Shellfish Immunol. 2019 Mar;86:559-570. doi: 10.1016/j.fsi.2018.11.056. PubMed" 38 FPDB00255 AP03239|||AP03239|||Phylloseptin-PTa|||Phylloseptin-PTa|||AP03239|||DRAMP32064 FLSLIPKIAGGIAALAKHL Anti-S. aureus NCTC 10788, activity value is MIC = 4.14 uM||Anti-E. faecalis NCTC 12697, activity value is MIC = 16.56 uM||Anti-E. coli NCTC 10418, activity value is MIC = 16.56 uM||Anti-C. albicans NCYC 1467, activity value is MIC = 2.07 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Antibiofilm||Anticancer||Anti-S. aureus NCTC 10788, activity value is MIC = 64 ug/ml||Anti-MRSA NCTC 12493, activity value is MIC = 64 ug/ml||Anti-E. faecalis NCTC 12697, activity value is MIC = 512 ug/ml||Anti-C. albicans NCYC 1, activity value is MIC = 256 ug/ml||Antimicrobial skin secretions, the Brown-bellied Leaf Frog, Phyllomedusa tarsius, South America|||Phyllomedusa tarsius [Brownbelly leaf frog]|||Phyllomedusa baltea|||skin secretions, the Brown-bellied Leaf Frog, Phyllomedusa tarsius, South America Helix "skin secretions, the Brown-bellied Leaf Frog, Phyllomedusa tarsius, South America|||Horse erythrocytes (HC50= 22.8 uM)|||The document clearly provides detailed hemolytic data for two types of antimicrobial peptides in leaf frogs (phylloseptin-PTa and phylloseptin-PHa), with the core information as follows: 1. Key hemolytic markers (Tsushima erythrocytes) The hemolytic properties of the two peptides were measured by hemolysis rates at half the hemolytic concentration (HC₅₀), 10% hemolytic concentration (HC₁₀), and minimum inhibitory concentration (MIC). Specific data are shown in Table 2: Peptide Name Hemolytic Rate at S. aureus MIC HC₁₀(uM) HC₅₀(uM) phylloseptin-PTa 4.42% 7.79 22.8 phylloseptin-PHa 2.52% 76.5 109.5 - HC₁₀: The concentration of peptides inducing 10% red blood cell hemolysis; the higher the value, the lower the hemolytic activity at lower concentrations; - HC₅₀: The concentration of peptides inducing 50% hemolysis of red blood cells; the higher the value, the lower the overall hemolysis; - Both have hemolytic rates below 5% at MIC concentrations targeting Staphylococcus aureus (S. aureus), with phylloseptin-PHa being only 2.52%, indicating lower hemolytic toxicity. 2. Experimental Background and Safety Verification - Experimental method: 4% red blood cell suspension was prepared from defibrotic horse blood and incubated with peptides of different concentrations (1~512 uM) at 37°C for 2 hours. The absorbance of the supernatant at 550 nm (reflecting hemoglobin release) was measured. The 2% Triton X-100 treatment group was used as the 100% hemolytic positive control and 1% DMSO/PBS as the solvent control. The hemolysis rate was calculated using formulas. - Security Comparison: 1. The hemolytic properties of both peptides are significantly lower than those of most highly toxic antimicrobial peptides (for example, some frog-derived peptides have hemolytic rates exceeding 10% under MIC); 2. Combined with treatment index (TI) analysis (Table 3), the ratio of HC₁₀ to MIC/MBEC (minimum biofilm clearance concentration) for inhibiting Gram-positive bacteria and clearing Staphylococcus aureus biofilms was greater than 1, indicating a low risk of hemolysis at effective antibacterial concentrations; 3. Cytotoxicity tests on human microvascular endothelial cells (HMEC-1) showed that phylloseptin-PHa showed mild toxicity at test concentrations, while phylloseptin-PTa showed significant toxicity only at 100 uM, further confirming their safety against normal mammalian cells. In summary, both types of antimicrobial peptides in leaf frogs exhibit low hemolytic characteristics, with phylloseptin-PHa having lower hemolytic activity, providing important safety evidence for its use as an anti-infective drug candidate.|||Horse erythrocytes (HC50= 22.8 uM)|||Horse erythrocytes: 10% Hemolysis=7.79 uM; 50% Hemolysis=22.8 uM" "Liu J, Wu Q, Li L, Xi X, Wu D, Zhou M, Chen T, Shaw C, Wang L.2017 Molecules. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428. PubMed|||Molecules . 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428.|||Molecules . 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428.|||28850103|||Molecules. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428. PubMed|||28850103|||Molecules . 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428.|||Molecules. 2017 Aug 29;22(9):1428.|||Molecules. 2017 Aug 29;22(9):1428. doi: 10.3390/molecules22091428. PubMed" 19 FPDB00257 AP03224|||AP03224|||Dermaseptin PD-2|||Dermaseptin PD-2|||AP03224 GMWSKIKNAGKAAAKAAAKAAGKAALDAVSEAI Anti-Strongly active against E. coli, activity value is MIC = 5 uM||Anti-S. aureus, activity value is MIC = 5 uM||Anti-P. aeruginosa, activity value is MIC = 2.5 uM||Antibacterial||Antifungal||Anti-Escherichia coli NCTC 10418, activity value is MIC = 5 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 20.2 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 5 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 10.1 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 10.1 uM||Anti-Candida albicans NCPF 1467, activity value is MBC = 20.2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 2.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 10.1 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 13.43 uM||Anti-Human squamous lung carcinoma NCI-H157, activity value is IC50 = 6.43 uM||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 3.17 uM||Anti-Gram+ & Gram-||candidacidal||Anticancer Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Pachymedusa dacnicolor|||Pachymedusa dacnicolor|||Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Skin Secretion, Pachymedusa dacnicolor, Mexico, North America Rich Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Horse erythrocytes (- at NA|||Horse erythrocytes (- at NA "Shi D, Hou X, Wang L, Gao Y, Wu D, Xi X, Zhou M, Kwok HF, Duan J, Chen T, Shaw C. 2016 Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144. PubMed|||Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144.|||27187467|||27187467|||Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144.|||Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144. PubMed" 33 FPDB00258 AP03223|||AP03223|||Dermaseptin PD-1|||Dermaseptin PD-1|||AP03223 GMWSKIKETAMAAAKEAAKAAGKTISDMIKQ Anti-E. coli, activity value is MIC = 19.6 uM||Anti-S. aureus, activity value is MIC = 39.2 uM||Anti-P. aeruginosa, activity value is MIC = 19.6 uM||Antibacterial||Antifungal||Anti-Escherichia coli NCTC 10418, activity value is MIC = 19.6 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 39.2 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 39.2 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 78.4 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 39.2 uM||Anti-Candida albicans NCPF 1467, activity value is MBC = 78.4 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 19.6 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 78.4 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 15.08 uM||Anti-Gram+ & Gram-||candidacidal||Anticancer Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Pachymedusa dacnicolor|||Pachymedusa dacnicolor|||Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Skin Secretion, Pachymedusa dacnicolor, Mexico, North America N/A Skin Secretion, Pachymedusa dacnicolor, Mexico, North America|||Horse erythrocytes (- at NA|||Horse erythrocytes (- at NA "Shi D, Hou X, Wang L, Gao Y, Wu D, Xi X, Zhou M, Kwok HF, Duan J, Chen T, Shaw C. 2016 Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144. PubMed|||Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144.|||27187467|||27187467|||Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144.|||Toxins (Basel) . 2016 May 12;8(5):144. doi: 10.3390/toxins8050144. PubMed" 31 FPDB00259 AP03219|||AP03219|||Kassiniatuerin-3|||Kassiniatuerin-3|||AP03219|||DRAMP32285 FIQHLIPLIPHAIQGIKDIF Anti-moderately to weakly active against S. aureus, activity value is MIC = 16||Anti-MRSA, activity value is MIC = 32||Anti-E.faecalis, activity value is MIC = 128 uM||Anti-E.coli, activity value is MIC > 512 uM||Anti-and C. albicans, activity value is MIC = 64||Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 16||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 32||Anti-Escherichia coli NCTC 10418, activity value is MIC > 512 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC > 512 uM||Anti-Candida albicans NCYC 1467, activity value is MIC = 64||Anti-Candida albicans NCYC 1467, activity value is MFC = 128 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MIC = 32||Anti-Staphylococcus aureus NCTC 12493, activity value is MBC = 64||Anti-Enterococcus faecalis NCTC 12697, activity value is MIC = 128 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MBC = 128 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 512 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC > 512 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 13.2 uM||Anti-Human prostate adenocarcinoma LNCaP, activity value is IC50 = 3.79 uM||Anti-Human lung adenocarcinoma NCI-H838, activity value is IC50 = 10.03 uM||Anti-Human lung carcinoma NCI-H460, activity value is IC50 = 1.67 uM||Anti-Human squamous lung carcinoma NCI-H157, activity value is IC50 = 21.54 uM||Anti-Human lung adenocarcinoma NCI-H23, activity value is IC50 = 4.52 uM||Antimicrobial Kassina senegalensis, Africa|||Kassina senegalensis|||Skin Secretion of the African Frog, Kassina senegalensis|||Skin Secretion of the African Frog, Kassina senegalensis Helix "50% hemolysis at a concentration of 65000000 uM|||In this document, the key information related to the hemolytic activity of a novel antimicrobial peptide Kassinatuerin-3, derived from the skin of the African frog (Kassina senegalensis), is as follows, as determined by the horse red blood cell hemolysis assay (0.1% Triton X-100 as 100% hemolytic positive control, PBS as 0% hemolytic negative control): Core Hemolytic Activity Results - Tested concentration range: 5–160 μM (covering its effective antimicrobial concentrations, such as MIC against Staphylococcus aureus = 16–32 μM, MIC against MRSA = 32–64 μM) - Kassinatuerin-3 hemolysis values: - No hemolysis at low concentrations: No significant hemolytic activity was detected at concentrations of 160 μM and below (hemolysis rate <1%). This concentration is far higher than the effective antimicrobial concentration against Gram-positive bacteria (16–64 μM), indicating almost no hemolytic toxicity during antimicrobial activity. - Slight hemolysis at high concentrations: Slight hemolysis only occurred when concentrations exceeded 160 μM; however, the document did not mention the exact hemolysis rates at specific higher concentrations (e.g., 256 μM, 512 μM). - Comparison with homologous peptides and positive control: - The homologous peptide Kassinatuerin-2Ma (from Kassina maculata) showed a hemolysis rate of 40%–50% at 120 μM, whereas Kassinatuerin-3 showed no hemolysis at 160 μM, indicating significantly lower hemolytic toxicity; - The positive control melittin, although exhibiting strong antimicrobial activity (MIC against Staphylococcus aureus = 1–2 μM), has extremely high hemolytic toxicity and lacks clinical safety, whereas Kassinatuerin-3 demonstrates a higher therapeutic index (ratio of antimicrobial activity to hemolytic toxicity).|||Kassina senegalensis, Africa||At a concentration of up to 160 μM, Kassinatuerin-3 did not show detectable hemolytic activity, with slight activity observed above this concentration. Kassinatuerin-1, which has a net charge of +2, has a MIC of 6.25 μM against Staphylococcus aureus, but induces 50% hemolysis at a concentration of 65 μM.|||Horse erythrocytes (2.5% Hemolysis at 160 uM|||The document clearly provides the hemolytic data of the novel antimicrobial peptide Kassinatuerin-3 on equine red blood cells. The core information is as follows: 1. Critical hemolytic value (for equine red blood cells) Core characteristics: Kassinatuerin-3 hemolysis is very weak, no obvious hemolytic activity at most concentrations tested in the experiment. At concentrations ≤ 160 uM: no detectable hemolytic activity (hemolysis ratio ≈ 0%). At concentrations> 160 uM: showed only slight hemolytic activity (specific values not explicitly quantified but significantly lower than the positive control). 2. Experimental Controls and Supplementary Notes Comparison settings: Negative control (PBS treatment): No hemolysis (hemolysis rate = 0%). Positive control (0.1% Triton X-100 treatment): complete hemolysis (hemolysis rate = 100%), used to calibrate the detection system. The correlation between hemolytic activity and antibacterial activity: The minimum inhibitory concentration (MIC) of Kassinatuerin-3 against gram-positive bacteria (such as S. aureus and MRSA) is 16-64 uM, and the minimum bactericidal concentration (MBC) is 32-128 uM, which are far lower than the concentration (>160 uM) that produces slight hemolysis, reflecting a high therapeutic index (high ratio of antibacterial activity to hemolytic toxicity). Comparison with similar peptides: The Kassinatuerin-2Ma of the same genus (net charge is the same as that of the Kassinatuerin-3, both are +1) has a hemolysis rate of 40% ~ 50% at 120 uM concentration, while the Kassinatuerin-3 still has no hemolysis at 160 uM, indicating that it has higher selectivity and lower toxicity to mammalian red blood cells.|||Horse erythrocytes (2.5% Hemolysis at 160 uM|||At a concentration of up to 160 μM, Kassinatuerin-3 did not show detectable hemolytic activity, with slight activity observed above this concentration. Kassinatuerin-1, which has a net charge of +2, has a MIC of 6.25 μM against Staphylococcus aureus, but induces 50% hemolysis at a concentration of 65 μM.|||Human RBCs: Kassinatuerin-3 produced no detectable hemolysis activity up to a concentration of 160 uM|||Kassinatuerin-3 produced no detectable hemolysis activity up to a concentration of 160 uM, above which there was slight activity (Figure5a)." "Wang H, He H, Chen X, Zhou M, Wei M, Xi X, Ma C, Du Q, Che T, Shaw C, Wang L. 2020 Biology (Basel) . 2020 Jul 2;9(7):E148. doi: 10.3390/biology9070148. PubMed|||Biology (Basel) . 2020 Jul 2;9(7):148. doi: 10.3390/biology9070148.|||Biology (Basel) . 2020 Jul 2;9(7):148. doi: 10.3390/biology9070148.|||32630734|||Biology (Basel) . 2020 Jul 2;9(7):E148. doi: 10.3390/biology9070148. PubMed|||32630734|||Biology (Basel) . 2020 Jul 2;9(7):148. doi: 10.3390/biology9070148.|||Biology (Basel). 2020 Jul 2;9(7):148.|||Biology (Basel) . 2020 Jul 2;9(7):E148. doi: 10.3390/biology9070148. PubMed" 20 FPDB00260 AP03217|||AP03217|||Phylloseptin-PBa2|||Phylloseptin-PBa2|||AP03217 FLSLLPHIASGIASLVSKF Anti-S. aureus, activity value is MIC = 5 uM||Anti-C. albicans, activity value is MIC = 15 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 200 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 5 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 15 uM||Anti-Gram+||Antifungal||candidacidal||Hemolytic||Anticancer Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America|||Phyllomedusa burmeisteri [Burmeister's leaf frog]|||Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America N/A Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America|||Hourse red blood cells(100% hemolysis at 2 uM)|||Hourse red blood cells(100% hemolysis at 2 uM)|||These three phylloseptins exhibited different degrees of hemo lytic activities against red blood cells. Nevertheless, Phylloseptin PBa3 showed a much weaker effect than Phylloseptin-PBa1 and-PBa2, the HC50 of Phylloseptin-PBa1,-PBa2 and-PBa3 were 18.6 uM, 15.82 uM and 53.98 uM, respectively (Fig. 4. C). "Wu Y, Wang L, Zhou M, Chen T, Shaw C.2019 Biochem Biophys Res Commun. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. PubMed|||Biochem Biophys Res Commun . 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. Epub 2019 Jan 3.|||30612735|||30612735|||Biochem Biophys Res Commun . 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. Epub 2019 Jan 3.|||Biochem Biophys Res Commun. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. PubMed" 19 FPDB00261 AP03216|||AP03216|||Phylloseptin-PBa1|||Phylloseptin-PBa1|||AP03216 FLSLIPHIASGIASLVKNF Anti-S. aureus, activity value is MIC = 5 uM||Anti-C. albicans, activity value is MIC = 20 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 200 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 5 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 20 uM||Anti-Gram+||Antifungal||candidacidal||Hemolytic||Anticancer Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America|||Phyllomedusa burmeisteri [Burmeister's leaf frog]|||Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America N/A Burmeister's leaf frog. Phyllomedusa burmeisteri , Brazil, South America|||Hourse red blood cells(100% hemolysis at 2 uM)|||Hourse red blood cells(100% hemolysis at 2 uM)|||These three phylloseptins exhibited different degrees of hemo lytic activities against red blood cells. Nevertheless, Phylloseptin PBa3 showed a much weaker effect than Phylloseptin-PBa1 and-PBa2, the HC50 of Phylloseptin-PBa1,-PBa2 and-PBa3 were 18.6 uM, 15.82 uM and 53.98 uM, respectively (Fig. 4. C). "Wu Y, Wang L, Zhou M, Chen T, Shaw C.2019 Biochem Biophys Res Commun. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. PubMed|||Biochem Biophys Res Commun . 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. Epub 2019 Jan 3.|||30612735|||30612735|||Biochem Biophys Res Commun . 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. Epub 2019 Jan 3.|||Biochem Biophys Res Commun. 2019 Feb 12;509(3):664-673. doi: 10.1016/j.bbrc.2018.12.156. PubMed" 19 FPDB00265 AP03133|||AP03133|||Dermaseptin-PT9|||Dermaseptin-PT9|||AP03133 GLWSKIKDAAKTAGKAALGFVNEMV Anti-S. aureus NCTC 10788, activity value is MIC = 16 uM||Anti-MRSA NCTC 12493, activity value is MIC = 32 uM||Anti-E. faecalis NCTC 12697, activity value is MIC = 16 uM||Anti-E. coli NCTC 10418, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 16 uM||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 8 uM||Anti-and C. albicans NCYC 1467, activity value is MIC = 64 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Anti-C. albicans NCYC 1467, activity value is MIC = 64 uM skin secretion, Phyllomedusa tarsius, Purchased in Peru, South America|||Phyllomedusa tarsius|||Phyllomedusa tarsius|||skin secretion, Phyllomedusa tarsius, Purchased in Peru, South America|||skin secretion, Phyllomedusa tarsius, Purchased in Peru, South America Helix skin secretion, Phyllomedusa tarsius, Purchased in Peru, South America|||Horse erythrocytes [HC50 = 210 uM]|||Horse erythrocytes [HC50 = 210 uM] "Li M, Xi X, Ma C, Chen X, Zhou M, Burrows JF, Chen T, Wang L.2019 Biomolecules. 2019 Oct 18;9(10). pii: E628. doi: 10.3390/biom9100628. PubMed|||Biomolecules . 2019 Oct 18;9(10):628. doi: 10.3390/biom9100628.|||Biomolecules . 2019 Oct 18;9(10):628. doi: 10.3390/biom9100628.|||31635388|||Biomolecules. 2019 Oct 18;9(10). pii: E628. doi: 10.3390/biom9100628. PubMed|||31635388|||Biomolecules . 2019 Oct 18;9(10):628. doi: 10.3390/biom9100628.|||Biomolecules. 2019 Oct 18;9(10). pii: E628. doi: 10.3390/biom9100628. PubMed" 25 FPDB00266 AP03087|||AP03087|||Limnonectes fujianensis Brevinvin|||Limnonectes fujianensis Brevinvin|||AP03087 GLFSVVKGVLKGVGKNVSGSLLDQLKCKISGGC Anti-S. aureus, activity value is MIC = 16 ug/ml||Anti-E. coli, activity value is MIC = 32 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 64 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||Anti-Candida albicans, activity value is MIC = 64 ug/ml||Anti-Gram+ & Gram-||candidacidal||Anticancer the Fujian Large Headed Frog, Limnonectes fujianensi, China, Asia|||Limnonectes fujianensis [Fujian Frog]|||Limnonectes fujianensis [Fujian Frog]|||the Fujian Large Headed Frog, Limnonectes fujianensi, China, Asia|||the Fujian Large Headed Frog, Limnonectes fujianensi, China, Asia Helix LFB exhibited significantly high hemolytic activity at a concentration of 16 ug/ml and above (Figure 5C)|||the Fujian Large Headed Frog, Limnonectes fujianensi, China, Asia|||Human erythrocytes (100% hemolysis at 500 ug/ml)|||Human erythrocytes (100% hemolysis at 500 ug/ml)|||This assay demonstrated that LFB exhibited significantly high hemolytic activity at a concentration of 16 ug/ml and above (Figure 5C). Each assay was carried out over three individual experiments and the standard errors were typically <5% of the mean. "Li B, Lyu P, Xie S, Qin H, Pu W, Xu H, Chen T, Shaw C, Ge L, Kwok HF.2019 Biomolecules. 2019 Jun 21;9(6). pii: E242. doi: 10.3390/biom9060242. PubMed|||Biomolecules . 2019 Jun 21;9(6):242. doi: 10.3390/biom9060242.|||31234333|||31234333|||Biomolecules . 2019 Jun 21;9(6):242. doi: 10.3390/biom9060242.|||Biomolecules. 2019 Jun 21;9(6). pii: E242. doi: 10.3390/biom9060242. PubMed" 33 FPDB00269 AP03049|||VLL28|||AP03049 VLLVTLTRLHQRGVIYRKWRHFSGRKYR activity value is MIC = 90||Anti-B. subtilis AZ54, activity value is MIC = 3 uM||Anti-E. coli DH5alpha, activity value is MIC = 1.5 uM||Anti-P. aeruginosa PAOI or PA14 or RP73, activity value is MIC = 3||Anti-C. parapsilosis 3 or 10, activity value is MIC = 25 uM||Anti-C. tropicalis 54 or 2, activity value is MIC = 12.5 uM||Anti-C. glabrata 28 or 34, activity value is MIC = 50 uM||Anti-and C. krusei, activity value is MIC = 25 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibiofilm||Anticancer||Anti-Candida albicans ATCC10231, activity value is MIC = 25 uM||Anti-Candida albicans 80, activity value is MIC = 25 uM||Anti-Candida albicans 81, activity value is MIC = 25 uM||Anti-C. parapsilosis 3, activity value is MIC = 25 uM||Anti-C. parapsilosis 10, activity value is MIC = 25 uM||Anti-C. tropicalis 54, activity value is MIC = 12.5 uM||Anti-C. tropicalis 2, activity value is MIC = 12.5 uM||Anti-C. glabrata 28, activity value is MIC = 50 uM||Anti-C. glabrata 34, activity value is MIC = 50 uM||Anti-C. krusei 1, activity value is MIC = 25 uM||Anti-C. krusei 14, activity value is MIC = 25 uM Sulfolobus islandicus Helix Sulfolobus islandicus "Notomista E, Falanga A, Fusco S, Pirone L, Zanfardino A, Galdiero S, Varcamonti M, Pedone E, Contursi P.2015 Microb Cell Fact. 2015 Sep 4;14:126. doi: 10.1186/s12934-015-0302-9. PubMed||this ref||Roscetto E et al. 2018|||Microb Cell Fact . 2015 Sep 4:14:126. doi: 10.1186/s12934-015-0302-9.||this ref||Roscetto E et al. 2018|||Microb Cell Fact. 2015 Sep 4;14:126. doi: 10.1186/s12934-015-0302-9. PubMed|||30514888|||Microb Cell Fact . 2015 Sep 4:14:126. doi: 10.1186/s12934-015-0302-9.||this ref||Roscetto E et al. 2018|||Microb Cell Fact. 2015 Sep 4;14:126. doi: 10.1186/s12934-015-0302-9. PubMed" 28 FPDB00270 AP03041|||AP03041|||CAMPSQ12278|||DRAMP29104|||AP03041|||DRAMP29104 LNLKALLAVAKKIL Anti-E. faecalis, activity value is MIC = 4||Anti-S. aureus or MRSA, activity value is MIC = 2||Anti-E. coli, activity value is MIC = 4||Anti-P. aeruginosa, activity value is MIC = 8||Anti-and C. albicans, activity value is MIC = 4||Anti-Gram+ B. cereus ATCC 11778, activity value is MIC = 4 uM||Anti-L. monocytogenes ATCC 15313, activity value is MIC = 8 uM||Anti-S. enterica ATCC 13076, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Antibiofilm||Anticancer||Anti-S.aureus NCTC 10788, activity value is MIC = 2 uM||Anti-E.coli NCTC 10418, activity value is MIC = 4 uM||Anti-C.albicans NCTC 1467, activity value is MIC = 4 uM||Anti-S.aureus MRSA ATCC 12493, activity value is MIC = 4 uM||Anti-P.aeruginosa ATCC 27853, activity value is MIC = 8 uM||Anti-E.faecalis NCTC 12697, activity value is MIC = 8 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 2 uM||activity value is MIC = 4||Anti-Escherichia coli NCTC 10418, activity value is MIC = 4 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 8 uM||Anti-Candida albicans NCTC 1467, activity value is MIC = 4 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4 uM||Anti-Bacillus subtilis ATCC 23857, activity value is MIC = 4 uM||activity value is MIC = 4 uM||activity value is MIC = 8 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 8 uM||activity value is MIC = 16 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 2 uM||activity value is MBC = 4 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MIC = 8 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MBC = 8 uM||Anti-##Gram-negative bacteria:Escherichia coli NCTC 10418, activity value is MIC = 4 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 16 uM||Anti-Candida albicans NCTC 1467, activity value is MBC = 4 uM||Anti-##Cancer:Human squamous lung carcinoma NCI-H157, activity value is IC50 = 13.57 uM||Anti-Human breast adenocarcinoma MDA-MB-435S, activity value is IC50 = 27.7 uM||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 6.29 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 36.65 uM||Anti-Human breast adenocarcinoma MCF-7, activity value is IC50 = 25.27 uM venom, the European Hornet, Vespa crabro|||venom, the European Hornet, Vespa crabro, Europe (introuced to US)|||Vespa crabro [European hornet]|||Vespa crabro|||venom, the European Hornet, Vespa crabro, Europe (introuced to US)|||Vespa crabro|||venom, the European Hornet, Vespa crabro, Europe (introuced to US) Helix||Alpha helix,random coil "causing no hemolysis to human erythrocytes within 200 uM|||In this document, the key values related to hemolysis for mastoparan-C (MP-C) derived from European hornet (Vespa crabro) venom and its two modified analogs (cyclic cMP-C and TAT-conjugated tMP-C) are as follows, measured using a horse red blood cell hemolysis assay (with 1% Triton X-100 as the 100% hemolysis positive control and PBS as the 0% hemolysis negative control): Core Hemolytic Activity Results - Test Indicator: Hemolytic toxicity of the three peptides was evaluated using the half hemolysis concentration (HC_{50}, i.e., the peptide concentration inducing 50% hemolysis of horse red blood cells) as the core indicator. - HC_{50} values of each peptide: - MP-C (natural peptide): HC_{50}=40.11 μM, moderate hemolytic activity; its effective antibacterial concentration (MIC against sensitive bacteria = 2–8 μM) is much lower than HC_{50}, and its toxicity to normal cells (human microvascular endothelial cells HMEC-1) is relatively low (IC₅₀=57.15 μM), resulting in a high therapeutic index. - cMP-C (cyclic modified peptide): HC_{50}=9.19 μM, hemolytic activity significantly increased (4.4 times that of the natural peptide), and its hemolytic concentration is lower than the antibacterial concentration for most cancer cells...|||venom, the European Hornet, Vespa crabro|||Horse RBCs (HC50 = 40.11 uM)|||[Ref.29904274]50% hemolysis against horse erythrocytes at 40.11 uM.##[Ref.33285267]10% hemolysis against mouse erythrocytes at 64 uM; 60% hemolysis against mouse erythrocytes at 256 uM.|||Similar results were obtained by Yoon et al. (antimicrobial activity against E.coli ATCC 11775 (MIC>1000 uM), S.aureus ATCC 12600 (MIC=500 uM), C.albicans ATCC 10231 (MIC=100 uM) and causing no hemolysis to human erythrocytes within 200 uM 25), although effective concentrations were up to two orders of magnitude higher than what we observed." "Chen X, Zhang L, Wu Y, Wang L, Ma C, Xi X, Bininda-Emonds ORP, Shaw C, Chen T, Zhou M.2018 Int J Biol Sci. 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. PubMed||combined with new data from ref for AP4034|||Int J Biol Sci . 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. eCollection 2018.|||Int J Biol Sci . 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. eCollection 2018.||combined with new data from ref for AP4034|||29904274|||Int J Biol Sci. 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. PubMed|||Int J Biol Sci. 2018 Apr 25;14(6):599-607.||Ref.29904274||Ref.33285267|||Int J Biol Sci . 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. eCollection 2018.||combined with new data from ref for AP4034|||Eur J Pharm Sci. 2021 Mar 1;158:105665.##Int J Biol Sci. 2018 Apr 25;14(6):599-607.||Ref.29904274||Ref.33285267|||Int J Biol Sci. 2018 Apr 25;14(6):599-607. doi: 10.7150/ijbs.23419. PubMed" 14 FPDB00272 AP03039|||AP03039|||Dermaseptin-PS1, Dermaseptin cDNA|||Dermaseptin-PS1, Dermaseptin cDNA|||AP03039 ALWKTMLKKLGTVALHAGKAALGAVADTISQ Anti-S. aureus, activity value is MIC = 10 uM||Anti-E. coli, activity value is MIC = 10 uM||Antibacterial||Antifungal||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 10 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 100 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 10 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 100 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 100 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 5.419 uM||Anti-Gram+ & Gram-||candidacidal||Anticancer skin, the waxy monkey tree frog, Phyllomedusa sauvagei, South America|||Phyllomedusa sauvagii|||Phyllomedusa sauvagii|||skin, the waxy monkey tree frog, Phyllomedusa sauvagei, South America|||skin, the waxy monkey tree frog, Phyllomedusa sauvagei, South America Helix skin, the waxy monkey tree frog, Phyllomedusa sauvagei, South America|||Horse erythrocytes (<20% Hemolysis at 10 uM|||Horse erythrocytes (<20% Hemolysis at 10 uM "Long Q, Li L, Wang H, Li M, Wang L, Zhou M, Su Q, Chen T, Wu Y.2018 J Cell Mol Med. 2019; 23 (10), 6797-6804. doi: 10.1111/jcmm.14032. PubMed|||J Invest Dermatol . 2019 May;139(5):1135-1142. doi: 10.1016/j.jid.2018.11.004. Epub 2018 Nov 20.|||30461197|||30461197|||J Invest Dermatol . 2019 May;139(5):1135-1142. doi: 10.1016/j.jid.2018.11.004. Epub 2018 Nov 20.|||J Cell Mol Med. 2019; 23 (10), 6797-6804. doi: 10.1111/jcmm.14032. PubMed" 31 FPDB00273 AP03016|||AP03016|||Dermaseptin DRS-DU-1|||Dermaseptin DRS-DU-1|||AP03016 ALWKSLLKNVGKAAGKAALNAVTDMVNQ Anti-S. aureus MRSA, activity value is MIC = 4 uM||Anti-P. aeruginosa, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anticancer||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 4 uM Callimedusa (Phyllomedusa) duellmani, Peru, South America|||Phyllomedusa duellmani|||Phyllomedusa duellmani|||Callimedusa (Phyllomedusa) duellmani, Peru, South America Helix "50% hemolysis of the red bloods cells|||This document focuses on the study of novel dermaseptin antimicrobial peptides discovered from the secretions of two types of frog skin, involving multiple aspects such as peptide cloning, synthesis, antimicrobial activity, and hemolytic activity testing. Among these, hemolytic activity was tested using horse red blood cells, with 1% DMSO as the negative control and Triton X-100 as the positive control. The hemolysis rate and the half-maximal hemolytic concentration (HC_{50}) were calculated by measuring absorbance at 550 nm. The specific values are as follows: Table Peptide | Half-Maximal Hemolytic Concentration (μM) | Hemolytic Activity Analysis --- | --- | --- DRS-CA-1 | 114.7 | At MIC or MBC concentrations, there is no significant hemolytic activity against the tested microorganisms except for Enterococcus faecalis; compared to other peptides with high hemolytic activity, this peptide has a lower hemolysis rate at relatively low concentrations and causes minimal damage to red blood cells. DRS-DU-1 | 216.6 | Has strong antimicrobial activity, with no significant hemolytic activity at MIC or MBC concentrations except against Enterococcus faecalis; higher than DRS-CA-1, indicating lower toxicity to red blood cells and causing less damage to normal cells while maintaining antimicrobial effects. DP-1 | | Has relatively low antimicrobial activity and almost no hemolytic activity; even at higher concentrations, it does not show significant hemolysis, making it safe for red blood cells, though its antimicrobial potency is weak. DP-2 | | Antimicrobial activity is restored, and its activity against Enterococcus faecalis is higher than that of natural peptides; shows no significant hemolytic activity, indicating a low risk of red blood cell damage while exerting antimicrobial effects, with potential application value.|||Callimedusa (Phyllomedusa) duellmani, Peru, South America||The MIC, MBC and HC50 values of all the peptides obtained from antimicrobial and hemolysis assays are summarized in Table 2. The two natural peptides, DRS-CA-1 and DRSDU-1, showed the same MIC values (4 uM) against S. aureus and E. coli and C. albicans. DRS-DU-1 was twofold more potent against MRSA, E. faecalis, K. pneumoniae and P. aeruginosa than DRS-CA-1. The MBC values of two natural peptides against seven tested microorganisms were two or four-fold higher than respective MICs. No obvious hemolysis activity was detected at the MIC or MBC concentrations except against E. faecalis. The two designed peptides also exhibited broad spectrum antimicrobial activities against the seven tested microorganisms, though the potency of DP-1 was much lower. However, the antimicrobial activities of DP-2 were restored comparing to DP-1. Additionally, the antimicrobial potency of DP-3 on E. faecalis was higher than the natural peptides.|||Horse erythrocytes (50% Hemolysis at 216.6 uM)|||Horse erythrocytes (50% Hemolysis at 216.6 uM)|||DRS-CA-1 and DRS-DU-1 exhibited strong antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi with no obvious hemolytic activity, and almost the same proportion of polar residues and nonpolar residues as well as the a-helical structure." "Zhu H, Ding X, Li W, Lu T, Ma C, Xi X, Wang L, Zhou M, Burden R, Chen T.2018 PeerJ. 2018 Sep 19;6:e5635. doi: 10.7717/peerj.5635. PubMed|||PeerJ . 2018 Sep 19:6:e5635. doi: 10.7717/peerj.5635. eCollection 2018.|||PeerJ . 2018 Sep 19:6:e5635. doi: 10.7717/peerj.5635. eCollection 2018.|||30258724|||30258724|||PeerJ . 2018 Sep 19:6:e5635. doi: 10.7717/peerj.5635. eCollection 2018.|||PeerJ. 2018 Sep 19;6:e5635. doi: 10.7717/peerj.5635. PubMed" 28 FPDB00274 AP03008|||AP03008|||Dermaseptin-4|||Dermaseptin DPS3|||Dermaseptin DPS3|||AP03008|||DRAMP01676 ALWKDILKNAGKAALNEINQIVQ Anti-E. coli NCTC 10418, activity value is MIC = 32 uM||Antibacterial||Antifungal||Anti-S. aureus NCTC 10788, activity value is MIC = 256 uM||Anti-C. albicans NCYC 1467, activity value is MIC = 64 uM||Antimicrobial||Anti-Gram+||Anti-Gram-||candidacidal||Anticancer skin secretion, Phyllomedusa sauvagii, USA, North America|||Phyllomedusa tarsius [Brownbelly leaf frog]|||Phyllomedusa sauvagii [waxy monkey tree frog]|||Phyllomedusa sauvagii [waxy monkey tree frog]|||skin secretion, Phyllomedusa sauvagii, USA, North America|||Phyllomedusa tarsius (Brownbelly leaf frog)|||skin secretion, Phyllomedusa sauvagii, USA, North America Helix skin secretion, Phyllomedusa sauvagii, USA, North America||All three peptides exhibited some haemolytic activity against healthy red blood cells (Figure 5). However, both artificial analogues exhibited a greater effect than the parent peptide, with the L10, 11-DPS3 analogue showing marked haemolysis even at lower concentrations. The HC50s of DPS3, K5, 17-DPS3 and L10, 11-DPS3 are 138.1, 14.98 and 3.44, respectively.|||Horse blood cells (HC50s = 138.1 uM )|||Horse blood cells (HC50s = 138.1 uM ) "Tan Y, Chen X, Ma C, Xi X, Wang L, Zhou M, Burrows JF, Kwok HF, Chen T.2018 Toxins (Basel). 2018 Aug 7;10(8). 320. doi: 10.3390/toxins10080320. PubMed|||Toxins (Basel) . 2018 Aug 7;10(8):320. doi: 10.3390/toxins10080320.|||30087268|||30087268|||Toxins (Basel) . 2018 Aug 7;10(8):320. doi: 10.3390/toxins10080320.|||Submitted (AUG-2006) to UniProtKB.|||Toxins (Basel). 2018 Aug 7;10(8). 320. doi: 10.3390/toxins10080320. PubMed" 23 FPDB00276 AP02977|||AP02977|||Temporin-PE|||Temporin-PE|||AP02977|||DRAMP18658 FLPIVAKLLSGLL Anti-S. aureus, activity value is MIC = 2 uM||Anti-MRSA, activity value is MIC = 4 uM||Anti-E. faecalis, activity value is MIC = 8 uM||Anti-and C. albicans, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anticancer||Anti-Staphylococcus aureus, activity value is MIC = 2 uM||Anti-Methicillin-resistant Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Enterococcus faecalis, activity value is MIC = 8 uM||Anti-Escherichia coli, activity value is MIC = 16 uM||Anti-Candida albicans, activity value is MIC = 4 uM||Anti-P. aeruginosa, activity value is MIC = 128 uM||Antibacterial||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 16 uM||Anti-##Fungus: Candida albicans, activity value is MIC = 4 uM||Anti-U251MG, activity value is IC50 = 25.13 uM||Anti-PC-3, activity value is IC50 = 38.56 uM||Anti-MDA-MB-435s, activity value is IC50 = 33.23 uM||Anti-HMEC-1, activity value is IC50 = 58.62 uM skin secretions, Pelophylax kl. esculentus, Europe|||Pelophylax kl.esculentus [Edible frog]|||Pelophylax kl.esculentus [Edible frog]|||skin secretions, Pelophylax kl. esculentus, Europe|||Pelophylax kl.esculentus(Europe edible frog)|||skin secretions, Pelophylax kl. esculentus, Europe Helix||Alpha helix Temporin-PE, temporin-PEa and temporin-PEb exhibited different degrees of hemolysis on horse erythrocytes with HC50 of 39.64 uM, 531.7 uM and 44.64 uM, respectively.|||svgsqq05aqe3x4h6uske|||skin secretions, Pelophylax kl. esculentus, Europe|||The hemolysis and pain induction of SvcAMPs have been reported in previous literature, noting that some SvcAMPs exhibit hemolytic activity against mammalian blood cells (Corzo et al., 2001; Gao et al., 2009; Harrison et al., 2016). This activity has long been considered a defensive strategy to repel small mammals. To provide further evidence to support this speculation, we collected blood cells from three of the most common vertebrates that feed on scorpions (mice, lizards, and birds; Polis, 1990) to evaluate the hemolytic activity of crude venom from Mesobuthus martensii and individual SvcAMPs. As shown in Figure 7A, snake venom diluted with 0.9% sodium chloride caused 50% hemolysis of mouse and lizard blood cells, and 25.7 ± 1.7% hemolysis of bird blood cells (Figure 7A). For individual peptide components, at a peptide concentration of 3.125 μM, all SvcAMPs exhibited varying degrees of hemolysis against mouse blood cells, with MeuFSPL1 and marmelittin showing the strongest hemolytic effects, at 61 ± 2.5% and 66 ± 1.2%, respectively. At this concentration, bee venom could cause complete hemolysis. As the peptide concentration increased to 6.25 μM, hemolytic activity of most SvcAMPs exceeded 50%, while the hemolytic activity of MeuFSPL-1 and marmelittin increased to nearly 100%. When the peptide concentration reached 12.5 μM, almost all peptides caused complete hemolysis except Meucin-13. Meucin-13 required 25 μM to achieve the same effect.|||[Ref.29191658]HC50=39.64 uM against horse red blood cells|||TAT is an arginine-rich decapeptide derived from HIV-1, an ideal cell-penetration segment to transit drugs through cell membranes via membrane translocation and endocytosis, with no hemolytic effects, mild antibiotic activity and inhibits the growth of fungi with MICs ranging from 3 uM to 24 uM [35]. "Sang M, Wu Q, Xi X, Ma C, Wang L, Zhou M, Burrows JF, Chen T.2018 Biochem Biophys Res Commun. 2018 Jan 22;495(4):2539-2546. doi: 10.1016/j.bbrc.2017.11.173. PubMed|||Biochem Biophys Res Commun . 2018 Jan 22;495(4):2539-2546. doi: 10.1016/j.bbrc.2017.11.173. Epub 2017 Nov 28.|||Biochem Biophys Res Commun . 2018 Jan 22;495(4):2539-2546. doi: 10.1016/j.bbrc.2017.11.173. Epub 2017 Nov 28.|||29191658|||29191658|||Biochem Biophys Res Commun . 2018 Jan 22;495(4):2539-2546. doi: 10.1016/j.bbrc.2017.11.173. Epub 2017 Nov 28.|||Biochem Biophys Res Commun. 2018 Jan 22;495(4):2539-2546.||Ref.29191658|||Biochem Biophys Res Commun. 2018 Jan 22;495(4):2539-2546. doi: 10.1016/j.bbrc.2017.11.173. PubMed" 13 FPDB00277 AP02976|||DRAMP01295 NLVSALIEGRKYLKNVLKKLNRLKEKNKAKNSKENN Anti-bacteria mainly Gram- E. coli, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa, activity value is MIC = 64 ug/ml||Antimicrobial||Anti-Gram-||Antifungal||candidacidal||Anticancer Skin Secretion, Phyllomedusa hypochondrialis, South America|||Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)|||Skin Secretion, Phyllomedusa hypochondrialis, South America N/A Skin Secretion, Phyllomedusa hypochondrialis, South America "Wu D, Gao Y, Tan Y, Liu Y, Wang L, Zhou M, Xi X, Ma C, Bininda-Emonds ORP, Chen T, Shaw C.2018 Front Microbiol. 2018 Mar 23;9:541. doi: 10.3389/fmicb.2018.00541. PubMed|||Front Microbiol . 2018 Mar 23:9:541.doi: 10.3389/fmicb.2018.00541.eCollection 2018.|||Front Microbiol . 2018 Mar 23:9:541. doi: 10.3389/fmicb.2018.00541. eCollection 2018.|||Thesis (2006), University of Ulster Coleraine, United Kingdom|||Front Microbiol. 2018 Mar 23;9:541. doi: 10.3389/fmicb.2018.00541. PubMed" 36 FPDB00279 AP02924 ALWKEVLKNAGKAALNEINNLV Anti-and C. albicans, activity value is MIC = 16||Anti-more effective against E. coli and C. albicans, activity value is MIC = 16 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibiofilm||Anticancer orange-legged leaf frog, Pithecopus (Phyllomedusa) hypochondrialis, South America|||orange-legged leaf frog, Pithecopus (Phyllomedusa) hypochondrialis, South America Helix "orange-legged leaf frog, Pithecopus (Phyllomedusa) hypochondrialis, South America|||The document explicitly mentions hemolytic information related to Dermaseptin-PH. The core conclusion is that it exhibits low cytotoxicity (low hemolysis) to mammalian red blood cells (horse red blood cells) within the effective antibacterial concentration range (16-64 µM), but does not provide specific hemolysis rate values. Key experimental background and details: 1. Experimental subjects: A 4% (v/v) red blood cell suspension prepared from defibrinated horse blood. 2. Experimental method: Red blood cells were incubated with different concentrations (1-512 µM) of Dermaseptin-PH at 37 °C for 2 hours. Hemolysis was assessed by measuring absorbance at 570 nm; the 1% (v/v) Triton X-100 treatment group served as the positive control (complete hemolysis), while the phosphate-buffered saline (PBS) treatment group served as the negative control (no hemolysis). 3. Core results: Within the key concentration range where Dermaseptin-PH exhibits antibacterial activity (16-64 µM, corresponding to the minimum inhibitory concentration [MIC] and minimum bactericidal concentration [MBC] for Escherichia coli, Staphylococcus aureus, Candida albicans, etc.), no significant hemolysis was observed, confirming its low toxicity to red blood cells and good safety profile. The document does not provide specific hemolysis percentage data at different concentrations, only qualitatively describing 'low cytotoxicity' and 'no obvious hemolysis,' and indicating its hemolytic characteristics through experimental observations (absorbance close to that of the negative control)." "Huang L, Chen D, Wang L, Lin C, Ma C, Xi X, Chen T, Shaw C, Zhou M.2017 Molecules. 2017 Oct 24;22(10). pii: E1805. doi: 10.3390/molecules22101805. PubMed|||Molecules . 2017 Oct 24;22(10):1805.doi: 10.3390/molecules22101805.|||Molecules. 2017 Oct 24;22(10). pii: E1805. doi: 10.3390/molecules22101805. PubMed|||Molecules . 2017 Oct 24;22(10):1805. doi: 10.3390/molecules22101805.|||Molecules. 2017 Oct 24;22(10). pii: E1805. doi: 10.3390/molecules22101805. PubMed" 22 FPDB00280 AP02921|||Bombinin H-BO1|||Bombinin H-BO1|||AP02921|||DRAMP32118 IIGPVLGLVGKALGGLL Anti-Weakly active against C. albicans, activity value is MIC = 160 uM||Anti-E. coli, activity value is MIC > 161.1 uM||Anti-S. aureus, activity value is MIC > 161.1 uM||Anti-C. albicans, activity value is MIC > 161.1 uM||Antimicrobial||Anticancer||Antifungal||candidacidal skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia|||Bombina orientalis [Oriental fire-bellied toad]|||skin secretion of Oriental fire-bellied toad, Bombina orientalis|||skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia N/A It caused only 2.89% hemolysis of the red cells at a concentration of 26.3 uM and 38.05% hemolysis at 52.5 uM.|||Human Red cells: caused 42.03% hemolysis of the red cells at a concentration of 40.3 uM while reaching 100% hemolysis at 161.1 uM|||Besides, Bombinin BO1 exhibited moderate hemolytic effect on human red blood cells. It caused only 2.89% hemolysis of the red cells at a concentration of 26.3 uM and 38.05% hemolysis at 52.5 uM. In contrast, Bombinin H-BO1 showed weak antibacterial action against C. albicans (161.1 uM for both MIC and MBC), and less effect on E. coli and S. aureus, whereas this peptide caused 42.03% hemolysis of the red cells at a concentration of 40.3 uM while reaching 100% hemolysis at 161.1 uM. "Peng X, Zhou C, Hou X, Liu Y, Wang Z, Peng X, Zhang Z, Wang R, Kong D.2017 Amino Acids. 2017 Nov 2. doi: 10.1007/s00726-017-2509-z. PubMed|||29098406|||29098406|||Amino Acids . 2018 Feb;50(2):241-253. doi: 10.1007/s00726-017-2509-z. Epub 2017 Nov 2.|||Amino Acids. 2018 Feb;50(2):241-253|||Amino Acids. 2017 Nov 2. doi: 10.1007/s00726-017-2509-z. PubMed" 17 FPDB00281 AP02920|||AP02920|||Bombinin-BO1|||Bombinin-BO1|||AP02920|||DRAMP32116 GIGSAILSAGKSIIKGLAKGLAEHF Anti-E. coli, activity value is MIC = 26 uM||Anti-S. aureus, activity value is MIC = 26 uM||Anti-C. albicans, activity value is MIC = 52 uM||Anti-E. coli, activity value is MIC = 26.3 uM||Anti-S. aureus, activity value is MIC = 26.3 uM||Anti-C. albicans, activity value is MIC = 52.5 uM||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia|||Bombina orientalis [Oriental fire-bellied toad]|||Bombina orientalis [Oriental fire-bellied toad]|||skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia|||Bombina orientalis|||skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia N/A "It caused only 2.89% hemolysis of the red cells at a concentration of 26.3 uM and 38.05% hemolysis at 52.5 uM.|||skin secretion, Oriental fire-bellied toad, Bombina orientalis, China, Asia||Besides, Bombinin- BO1 exhibited moderate hemolytic effect on human red blood cells. It caused only 2.89% hemolysis of the red cells at a concentration of 26.3 uM and 38.05% hemolysis at 52.5 uM. In contrast, Bombinin H-BO1 showed weak antibacterial action against C. albicans (161.1 uM for both MIC and MBC), and less effect on E. coli and S. aureus, whereas this peptide caused 42.03% hemolysis of the red cells at a concentration of 40.3 uM while reaching 100% hemolysis at 161.1 uM.|||Human erythrocytes: 2.89% Hemolysis=26.3 uM; Human erythrocytes=38.05% Hemolysis=52.5 uM|||Besides, Bombinin BO1 exhibited moderate hemolytic effect on human red blood cells. It caused only 2.89% hemolysis of the red cells at a concentration of 26.3 uM and 38.05% hemolysis at 52.5 uM. In contrast, Bombinin H-BO1 showed weak antibacterial action against C. albicans (161.1 uM for both MIC and MBC), and less effect on E. coli and S. aureus, whereas this peptide caused 42.03% hemolysis of the red cells at a concentration of 40.3 uM while reaching 100% hemolysis at 161.1 uM." "Peng X, Zhou C, Hou X, Liu Y, Wang Z, Peng X, Zhang Z, Wang R, Kong D.2017 Amino Acids. 2017 Nov 2. doi: 10.1007/s00726-017-2509-z. PubMed|||Amino Acids . 2018 Feb;50(2):241-253. doi: 10.1007/s00726-017-2509-z. Epub 2017 Nov 2.|||29098406|||29098406|||Amino Acids . 2018 Feb;50(2):241-253. doi: 10.1007/s00726-017-2509-z. Epub 2017 Nov 2.|||Amino Acids. 2018 Feb;50(2):241-253|||Amino Acids. 2017 Nov 2. doi: 10.1007/s00726-017-2509-z. PubMed" 25 FPDB00287 AP02730|||AP02730|||Smp43|||DRAMP18442|||AP02730|||DRAMP18442 GVWDWIKKTAGKIWNSEPVKALKSQALNAAKNFVAEKIGATPS Anti-B. subtilis NCIMB 8024, activity value is MIC = 4 ug/ml||Anti-S. aureus SH100, activity value is MIC = 32||Anti-and C. albicans, activity value is MIC = 64||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Anticancer venom, Scorpio maurus palmatus|||Scorpio maurus palmatus|||venom, Scorpio maurus palmatus|||venom, Scorpio maurus palmatus, Africa, Asia|||venom, Scorpio maurus palmatus, Africa, Asia Helix "venom, Scorpio maurus palmatus|||Sheep erythrocytes (<5% hemolysis at 512 ug/ml)|||Smp13: No antimicrobial activity, hemolytic data not explicitly mentioned, presumed to have no significant hemolysis. • Smp24: At a concentration of 512 µg/ml, the hemolysis rate reached 89.6% ± 5.6%, indicating strong hemolysis. • Smp24GVG (Pro-14 replaced by Gly-Val-Gly): At a concentration of 512 µg/ml, the hemolysis rate showed no significant difference compared to Smp24 (specific value not provided, only clearly stated as ""no obvious change""). • Smp24T (C-terminal truncated by 4 residues): At a concentration of 512 µg/ml, the hemolysis rate decreased by 43% compared to Smp24, approximately 51.1% (89.6% × (1-43%)). • Smp43: At a concentration of 512 µg/ml, the hemolysis rate was only 1.2% ± 0.5%, indicating extremely weak hemolysis." "Harrison PL, Abdel-Rahman MA, Strong PN, Tawfik MM, Miller K.2016 Toxicon. 2016 Jul;117:30-6. PubMed|||Toxicon. 2016 Jul;117:30-6. PubMed|||27019370|||Toxicon. 2016 Jul;117:30-6.|||Toxicon . 2016 Jul:117:30-6. doi: 10.1016/j.toxicon.2016.03.014. Epub 2016 Mar 24.|||Toxicon. 2016 Jul;117:30-6. PubMed" 43 FPDB00288 AP02729|||AP02729|||Smp24|||DRAMP18443|||Smp24|||AP02729|||DRAMP18443 IWSFLIKAATKLLPSLFGGGKKDS Anti-S. aureus SH100, activity value is MIC = 4||Anti-E. coli JM109, activity value is MIC = 64 ug/ml||Anti-and C. albicans, activity value is MIC = 32 ug/ml||Antibacterial||Antifungal||Anti-B. subtilis NCIMB 8024, activity value is MIC = 4 ug/ml||Anti-S. epidermidis sp, activity value is MIC = 8 ug/ml||Anti-S. aureus SH100, activity value is MIC = 8 ug/ml||Anti-K. pneumoniae NCTC 13439, activity value is MIC = 128 ug/ml||Anti-P.aeruginosa, activity value is MIC = 256 ug/ml||Anti-C. albicans, activity value is MIC = 32 ug/ml||Anti-Gram+ & Gram-||candidacidal||Anticancer venom, Scorpio maurus palmatus|||Scorpio maurus palmatus|||venom, Scorpio maurus palmatus|||Scorpio maurus palmatus|||venom, Scorpio maurus palmatus, Africa, Asia|||venom, Scorpio maurus palmatus, Africa, Asia Helix "venom, Scorpio maurus palmatus|||Sheep erythrocytes (90% hemolysis at 512 ug/ml)|||Smp13: No antimicrobial activity, hemolytic data not explicitly mentioned, presumed to have no significant hemolysis. • Smp24: At a concentration of 512 µg/ml, the hemolysis rate reached 89.6% ± 5.6%, indicating strong hemolysis. • Smp24GVG (Pro-14 replaced by Gly-Val-Gly): At a concentration of 512 µg/ml, the hemolysis rate showed no significant difference compared to Smp24 (specific value not provided, only clearly stated as ""no obvious change""). • Smp24T (C-terminal truncated by 4 residues): At a concentration of 512 µg/ml, the hemolysis rate decreased by 43% compared to Smp24, approximately 51.1% (89.6% × (1-43%)). • Smp43: At a concentration of 512 µg/ml, the hemolysis rate was only 1.2% ± 0.5%, indicating extremely weak hemolysis.|||Sheep erythrocytes (90% hemolysis at 512 ug/ml)" "Harrison PL, Abdel-Rahman MA, Strong PN, Tawfik MM, Miller K.2016 Toxicon. 2016 Jul;117:30-6. PubMed|||Toxicon. 2016 Jul;117:30-6. PubMed|||27019370|||Toxicon. 2016 Jul;117:30-6.|||27019370|||Toxicon . 2016 Jul:117:30-6. doi: 10.1016/j.toxicon.2016.03.014. Epub 2016 Mar 24.|||Toxicon. 2016 Jul;117:30-6. PubMed" 24 FPDB00298 AP02531|||AP02531|||Stigmurin|||DRAMP20933|||DRAMP21024|||Stigmurin|||AP02531|||DRAMP20933|||DRAMP21024 FFSLIPSLVGGLISAFK Anti-S. aureus ATCC 29213 or MRSA ATCC 33591, activity value is MIC = 8.68||Anti-S. epidermidis ATCC 122225, activity value is MIC = 9.38 uM||Anti-E.faecalis ATCC 4028, activity value is MIC > 150 uM||Anti-E.coli ATCC 25922, activity value is MIC > 139 uM||Anti-E.cloacae ATCC 13047, activity value is MIC > 150 uM||Anti-P.aeruginosa ATCC 27853, activity value is MIC > 150 uM||Anti-s C. albicans ATCC 90028, activity value is MIC = 34.75 uM||Anti-C. krusei ATCC 6258, activity value is MIC = 69.5||Anti-and C. glabrata ATCC 90030, activity value is MIC = 69.5||Anti-Gram+||Antifungal||candidacidal||Antioxidant||Anti-MRSA||Wound healing||Anticancer||Anti-Staphylococcus aureus, activity value is MIC = 9.4 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 9.4 uM||Anti-Candida albicans, activity value is MIC = 37.5 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 9.38 uM||Anti-Staphylococcus epidermidis ATCC 122225, activity value is MIC = 9.38 uM||Anti-s: Candida albicans ATCC 90028, activity value is MIC = 37.5 uM||Anti-HeLa cell line, activity value is IC50 = 7.98 uM||Anti-Enterococcus faecalis, activity value is MIC > 150 uM||Anti-Pseudomonas aeruginosa, activity value is MIC > 150 uM||Anti-Escherichia coli, activity value is MIC > 150 uM||Anti-Enterobacter cloacae, activity value is MIC > 150 uM||Anti-Candida glabrata, activity value is MIC > 150 uM||Anti-Candida krusei, activity value is MIC > 150 uM||Anti-##yeasts: Candida albicans ATCC 90028, activity value is MIC = 37.5 uM||Anti-##HeLa cell line, activity value is IC50 = 7.98 uM||Anti-##Gram-negative bacteria : Pseudomonas aeruginosa, activity value is MIC > 150 uM||Anti-##Fungi : Candida albicans, activity value is MIC = 37.5 uM venom gland, Tityus stigmurus|||venom gland, Tityus stigmurus, Brazil, South America|||Tityus stigmurus [Brazilian scorpion]|||Tityus stigmurus|||Scorpion Tityus stigmurus|||venom gland, Tityus stigmurus, Brazil, South America|||Tityus stigmurus|||Scorpion Tityus stigmurus|||venom gland, Tityus stigmurus, Brazil, South America Helix||Alpha helix "Hemolysis Rate at the Highest Test Concentration - Test concentration: 139.5 μM (the highest peptide concentration used in the experiment) - Hemolysis rate: 22% - Description: This value was determined by human red blood cell hemolysis assay. In the experiment, PBS (0% hemolysis, negative control) and distilled water (100% hemolysis, positive control) were used as references. Peptides were incubated with red blood cells at 37°C for 180 minutes, and the hemolysis percentage was calculated by measuring absorbance at 540 nm. The results indicate low hemolytic activity at this concentration. 2. Hemolysis Test Concentration Range - Concentration range: 1.1–139.5 μM - Result trend: At test concentrations below 139.5 μM, hemolysis rates were below 22%, and no significant hemolytic activity was observed (exact hemolysis rates at lower concentrations were not listed separately, but overall showed a concentration-dependent trend, with hemolysis reaching 22% only at the highest concentration). 3. Control Group Setup - Negative control: PBS (pH 7.4), no hemolytic effect (0% hemolysis). - Positive control: distilled water, inducing complete hemolysis (100% hemolysis), used for standardizing hemolysis rate calculations.|||venom gland, Tityus stigmurus||Stigmurin was found to possess low hemolytic activity (22 %)218at the highest concentration tested (139.5 uM), as shown in Figure 6|||hRBC, Non hemolytic|||-Detection object: healthy human O-type red blood cells, incubation conditions are 37 C, 1 hour, detection wavelength 540 nm. -Control settings: 0% hemolysis (PBS only, no peptides/triton), 100% hemolysis (triton Triton-X). -Natural peptide Stigmurin: very low hemolytic activity in the concentration range of 1.17-75 uM, with a hemolysis rate of only 3% at the highest concentration (75 uM). -Analogs StigA6 and StigA16: hemolysis rate is about 30% at the highest concentration (75 uM); However, at low concentrations (corresponding to MIC and effective concentration) that exert antibacterial and antiproliferative activities, the hemolysis rate is less than 10% and the toxicity is weak.|||- Test subject: human red blood cells, incubation conditions were 37°C for 1 hour, detection wavelength 540 nm; negative control (0.9% saline) showed 0% hemolysis, positive control (1% Triton X-100) showed 100% hemolysis. - Natural peptide Stigmurin: at the highest concentration (150 µM), the hemolysis rate was only 5.8%, indicating extremely low hemolytic activity. - Analogues StigA25 and StigA31: hemolytic activity was concentration-dependent, with weak hemolysis at low concentrations (effective antimicrobial concentrations): - At concentrations ≤ 9.4 µM, hemolysis rates were 18.5% for StigA25 and 11.2% for StigA31; - Hemolysis slightly increased at higher concentrations, but overall remained low, and showed no significant hemolytic toxicity at their minimum inhibitory concentrations (MIC, 1.2–4.7 µM). - Key correlation: the analogues had increased net charge through lysine substitutions (StigA25: 5, StigA31: 7, native peptide: 2), which significantly enhanced antimicrobial activity without a substantial increase in hemolytic activity, indicating good safety.|||hRBC, Non hemolytic|||Hemolytic activity of StigMurin. Human red blood cells were incubated with a series of diluted StigMurin (1.1–139.5 μM) at 37 °C for 3 hours. PBS and distilled water were used as negative and positive lysis controls, respectively, and the activity was measured at 540 nm. The hemolysis rate was calculated as 679% relative to the positive control (100%).|||[Ref.29670004]Hemolysis 0% at 1.17 uM, hemolysis 1% at 2.34 uM, hemolysis 1% at 4.69 uM, hemolysis 0% at 9.38 uM, hemolysis 1% at 18.75 uM, hemolysis 1% at 37.5 uM, hemolysis 3% at 75 uM against human red blood cell|||[Ref.30709056] 7% hemolysis at 1.2 ug/ml , 4% hemolysis at 2.3 ug/ml , 2% hemolysis at 4.7 ug/ml , 0% hemolysis at 9.4 ug/ml , 3% hemolysis at 18.8 ug/ml , 2% hemolysis at 37.5 ug/ml , 3% hemolysis at 75 ug/ml , 5% hemolysis at 150 ug/ml against human red blood cells|||Stigmurin was found to possess low hemolytic activity (22 %) at the highest concentration tested (139.5 uM), as shown in Figure 6." "Melo ET, Estrela AB, Santos EC, Machado PR, Farias KJ, Torres TM, de Carvalho E, Lima JP, Silva-Júnior AA, Barbosa EG, Fernandes-Pedrosa MF. 2015 Peptides. 2015 Jun;68:3-10. PubMed|||Peptides . 2015 Jun:68:3-10. doi: 10.1016/j.peptides.2015.03.003. Epub 2015 Mar 22.|||Peptides. 2015 Jun;68:3-10. PubMed|||30709056|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||Int J Mol Sci. 2019 Jan 31;20(3). pii: E623. doi: 10.3390/ijms20030623.||Ref.30709056|||30709056|||Peptides . 2015 Jun:68:3-10. doi: 10.1016/j.peptides.2015.03.003. Epub 2015 Mar 22.|||Toxins (Basel). 2018 Apr 18;10(4). pii: E161.||Ref.29670004|||Int J Mol Sci. 2019 Jan 31;20(3). pii: E623. doi: 10.3390/ijms20030623.||Ref.30709056|||Peptides. 2015 Jun;68:3-10. PubMed" 17 FPDB00299 AP02495|||AP02495|||AaeAP2|||DRAMP21252|||AaeAP2|||AP02495|||DRAMP21252 FLFSLIPSAIAGLVSAIRN Anti-C. albicans, activity value is MIC = 32 ug/ml||Anti-E.coli, activity value is MIC > 512 ug/ml||Anti-and S. aureus, activity value is MIC = 16 ug/ml||Animalia||Arachnida ; Androctonus aeneas||Anti-S. aureus, activity value is MIC = 16 ug/ml||Anti-C. albicans S, activity value is MIC = 32 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Antifungal||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||activity value is MBC = 16 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC > 512 ug/ml||Anti-##Fungi : Candida albicans, activity value is MIC = 32 ug/ml||activity value is MBC = 64 ug/ml||candidacidal||Anticancer Venom, Androctonus aeneas, Africa|||Androctonus aeneas|||Androctonus aeneas|||Venom, Androctonus aeneas, Africa|||Venom, Androctonus aeneas, Africa N/A Venom, Androctonus aeneas, Africa|||S. aureus (MIC= 16 ug/ml), E. coli (MIC= >512 ug/ml), C. albicans S (MIC= 32 ug/ml)||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||Horse RBCs ( 100% hemolysis at 64 ug/ml)|||[Ref.25626077] 100% hemolysis at 64 ug/ml against horse red blood cells "Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C.2015 Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed|||Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed|||https://pubmed.ncbi.nlm.nih.gov/25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||25626077|||Toxins (Basel) . 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.||Ref.25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed" 19 FPDB00300 AP02494|||AP02494|||AaeAP1|||DRAMP21251|||AaeAP1|||AP02494|||DRAMP21251 FLFSLIPSVIAGLVSAIRN Anti-C. albicans, activity value is MIC = 32 ug/ml||Anti-E.coli, activity value is MIC > 512 ug/ml||Anti-and S. aureus, activity value is MIC = 16 ug/ml||Antibacterial||Antifungal ; Androctonus aeneas||Anti-S. aureus, activity value is MIC = 16 ug/ml||Anti-C. albicans S, activity value is MIC = 32 ug/ml||Antimicrobial||Anti-Gram+||Antifungal||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||activity value is MBC = 32 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC > 512 ug/ml||Anti-##Fungi : Candida albicans, activity value is MIC = 32 ug/ml||activity value is MBC = 64 ug/ml||candidacidal||Anticancer Venom, Androctonus aeneas, Africa|||Androctonus aeneas|||Androctonus aeneas|||Venom, Androctonus aeneas, Africa|||Venom, Androctonus aeneas, Africa N/A Venom, Androctonus aeneas, Africa|||S. aureus (MIC= 16 ug/ml), E. coli (MIC= >512 ug/ml), C. albicans S (MIC= 32 ug/ml)||Horse RBCs ( 100% hemolysis at 16 ug/ml)|||Horse RBCs ( 100% hemolysis at 16 ug/ml)|||Horse RBCs ( 100% hemolysis at 16 ug/ml)|||[Ref.25626077] 100% hemolysis at 16 ug/ml against horse red blood cells "Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C.2015 Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed|||Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed|||https://pubmed.ncbi.nlm.nih.gov/25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||25626077|||Toxins (Basel) . 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.|||Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.||Ref.25626077|||Toxins (Basel). 2015 Jan 23;7(2):219-37. PubMed" 19 FPDB00303 AP02412|||AP02412|||Brevinin 2R KLKNFAKGVAQSLLNKASCKLSGQC Active against S. aureus||M. luteus||Bacillus spKR-8104||E. coli||S. typhimurium||P. aeruginosa||K. pneumonidae and fungi||such as C. albicans and C. tropicalis.||Anti-Escherichia coli ATCC 25922, activity value is MBC = 6.25 ug/ml||Anti-Human breast adenocarcinoma MCF-7, activity value is LD50 = 10||Anti-Jurkat T-cell leukemia, activity value is LD50 = 20||Anti-Mouse fibrosarcoma L929, activity value is LD50 = 20||Anti-Mouse B-cell lymphoma BJAB, activity value is LD50 = 30||Anti-Escherichia coli ATCC 25922, activity value is MBC = 1.56 ug/ml||Anti-Leishmania major MRHO/IR/75/ER, activity value is IC50 = 40||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer skin, Marsh frog, formerly Rana ridibunda , new name Pelophylax ridibunda, Europe|||Pelophylax ridibundus,Pelophylax esculentus|||skin, Marsh frog, formerly Rana ridibunda , new name Pelophylax ridibunda, Europe N/A skin, Marsh frog, formerly Rana ridibunda , new name Pelophylax ridibunda, Europe||Even at a concentration as high as 200 ug/ml, the hemolytic activity of Brevinin-2R against sheep red blood cells is only approximately 2.5%.|||Human erythrocytes (0% Hemolysis at 500 ug/ml, Human erythrocytes (50% Hemolysis at 250 ug/ml|||Low hemolytic activity of Brevinin 2R against sheep erythrocytes.Brevinin-2R at concentrations as high as 200 ug/ml resulted in only 2.5% hemolytic activity "Ghavami S, Asoodeh A, Klonisch T, Halayko AJ, Kadkhoda K, Kroczak TJ, Gibson SB, Booy EP, Naderi-Manesh H, Los M.2008 J Cell Mol Med. 2008 Jun;12(3):1005-22. doi: 10.1111/j.1582-4934.2008.00129.x. PubMed|||J Cell Mol Med. 2008 Jun;12(3):1005-22. doi: 10.1111/j.1582-4934.2008.00129.x. PubMed|||30811391, 18494941|||J Cell Mol Med . 2008 Jun;12(3):1005-22. doi: 10.1111/j.1582-4934.2008.00129.x.|||J Cell Mol Med. 2008 Jun;12(3):1005-22. doi: 10.1111/j.1582-4934.2008.00129.x. PubMed" 25 FPDB00305 AP02375|||AP02375|||Frenatin 2.2S|||DRAMP33487 GLVGTLLGHIGKAILS Anti-strains S. aureus and S. epidermidis, activity value is MIC = 8||Anti-C. albicans, activity value is MIC = 62.5 uM||Anti-A. baumannii clinical isolates NM75, activity value is MIC = 62.5 uM||Anti-S. maltophilia clinical isolates B32/1 B32/4 U8908 B5/5 B6/2, activity value is MIC = 31||Anti-Erwinia amylovora, activity value is MIC = 25||Anti-Xanthomonas arboricola pv. Pruni, activity value is MIC = 62||Anti-Xanthonomas axonopodis pv. vesicatoria, activity value is MIC = 6.2||Anti-Xanthomonas fragariae, activity value is MIC = 25||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal skin secretions, the Orinoco lime frog, Sphaenorhynchus lacteus, north central Guyana, South America|||Sphaenorhynchus lacteus|||skin secretions, the Orinoco lime frog, Sphaenorhynchus lacteus, north central Guyana, South America N/A 50% hemolysis|||skin secretions, the Orinoco lime frog, Sphaenorhynchus lacteus, north central Guyana, South America||The LC₅₀ (uM) for human red blood cells is 169±7.|||Horse blood cells(84 ± 1.8% hemolysis at 375 uM)|||The LC50 value was calculated using commercially available software (SPSS version 17.0) and was taken as the mean concentration of peptide producing 50% hemolysis in three independent experiments. "Conlon JM, Mechkarska M, Radosavljevic G, Attoub S, King JD, Lukic ML, McClean S.2014 Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed||Camó C et al. 2018|||Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed||Camó C et al. 2018|||30508634|||Peptides . 2014 Jun:56:132-40. doi: 10.1016/j.peptides.2014.03.020. Epub 2014 Apr 4.||Camó C et al. 2018|||Peptides. 2014 Jun;56:132-40.|||Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed" 16 FPDB00306 AP02374|||AP02374|||Frenatin 2.1S|||DRAMP33485|||DRAMP33486|||DRAMP33488|||DRAMP33489 GLVGTLLGHIGKAILG Anti-strains S. aureus and S. epidermidis, activity value is MIC = 8||Anti-C. albicans, activity value is MIC = 62.5 uM||Anti-and NM75, activity value is MIC = 62.5 uM||Anti-S. maltophilia clinical isolates, activity value is MIC = 31||Anti-Erwinia amylovora, activity value is MIC = 25||Anti-Xanthonomas axonopodis pv. vesicatoria, activity value is MIC = 3.1||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal skin secretions, the Orinoco lime frog, Sphaenorhynchus lacteus, north central Guyana, South America|||Sphaenorhynchus lacteus|||Guyana, South America N/A 50% hemolysis|||skin secretions, the Orinoco lime frog, Sphaenorhynchus lacteus, north central Guyana, South America||The LC₅₀ (uM) for human red blood cells is 167±8.|||Horse blood cells(86 ± 2.4% hemolysis at 375 uM)|||The LC50 value was calculated using commercially available software (SPSS version 17.0) and was taken as the mean concentration of peptide producing 50% hemolysis in three independent experiments. "Conlon JM, Mechkarska M, Radosavljevic G, Attoub S, King JD, Lukic ML, McClean S.2014 Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed||Camó C et al. 2018|||Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed||Camó C et al. 2018|||30508634|||Peptides . 2014 Jun:56:132-40. doi: 10.1016/j.peptides.2014.03.020. Epub 2014 Apr 4.||Camó C et al. 2018|||Peptides. 2014 Jun;56:132-40.|||Peptides. 2014 Apr 4;56C:132-140. doi: 10.1016/j.peptides.2014.03.020. PubMed" 16 FPDB00315 AP02319|||AP02319|||Pseudhymenochirin-2Pa|||Pseudhymenochirin-2Pa|||AP02319|||DRAMP31856 GIFPIFAKLLGKVIKVASSLISKGRTE Anti-S. aureus, activity value is MIC = 5||Anti-S. epidermidis, activity value is MIC = 2.5||Anti-E. faecalis, activity value is MIC = 20 um||Anti-and C. albicans, activity value is MIC = 80 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 20 uM||Anti-Escherichia coli ATCC 25726, activity value is MIC > 40 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5 uM||Anti-Escherichia coli ATCC 25726, activity value is MIC > 80 uM||Anti-Staphylococcus aureus 127/08, activity value is MIC = 5 uM||Anti-Staphylococcus aureus 145/08, activity value is MIC = 10 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 5 uM||Anti-Staphylococcus epidermidis RP62A/1, activity value is MIC = 2.5 uM||Anti-Staphylococcus epidermidis T6/19, activity value is MIC = 5 uM||Anti-Staphylococcus epidermidis T37/8, activity value is MIC = 10 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 20 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC > 80 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 80 uM||Anti-Acinetobacter baumannii NM8, activity value is MIC = 20 uM||Anti-Acinetobacter baumannii NM35, activity value is MIC = 10 uM||Anti-Stenotrophomonas maltophilia B32/1, activity value is MIC = 10 uM||Anti-Stenotrophomonas maltophilia B5/5, activity value is MIC = 40 uM||Anti-Stenotrophomonas maltophilia U8908, activity value is MIC = 20 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 80 uM||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-diabetes||Hemolytic skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Pseudhymenochirus merlini|||Pseudhymenochirus merlini|||skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||skin secretions of the frog Pseudhymenochirus merlini (Pipidae) Helix skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Human umbilical vein endothelial cells HUVEC (50% Cell death at 68+-2 uM, Human erythrocytes (50% Hemolysis at 6.2+-1 uM, Mouse erythrocytes (50% Hemolysis at 7+-2 uM|||Human umbilical vein endothelial cells HUVEC (50% Cell death at 68+-2 uM, Human erythrocytes (50% Hemolysis at 6.2+-1 uM, Mouse erythrocytes (50% Hemolysis at 7+-2 uM|||Human erythrocytes: LC50=6.2±1 uM|||highly hemolytic (LC50 6.2 uM) "Conlon JM, Prajeep M, Mechkarska M, Coquet L, Leprince J, Jouenne T, Vaudry H, King JD.2013 Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med|||24212286, 25447194, 26606380|||24212286, 25447194, 26606380|||Comp Biochem Physiol Part D Genomics Proteomics . 2013 Dec;8(4):352-7. doi: 10.1016/j.cbd.2013.10.002. Epub 2013 Oct 12.|||Regul Pept. 2014 Nov;194-195:69-76.|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med" 27 FPDB00316 AP02318|||AP02318|||Pseudhymenochirin-1Pb|||DRAMP31857 IKIPSFFRNILKKVGKEAVSLIAGALKQS Anti-S. aureus, activity value is MIC = 5||Anti-S. epidermidis, activity value is MIC = 1.25||Anti-E. faecalis, activity value is MIC = 10 uM||Anti-E. coli, activity value is MIC = 10 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5||Anti-Escherichia coli ATCC 25726, activity value is MIC = 10 uM||Anti-Staphylococcus aureus 127/08, activity value is MIC = 5 uM||Anti-Staphylococcus aureus 145/08, activity value is MIC = 10 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 2.5 uM||Anti-Staphylococcus epidermidis RP62A/1, activity value is MIC = 1.25 uM||Anti-Staphylococcus epidermidis T6/19, activity value is MIC = 2.5 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 10 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 20 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 20 uM||Anti-Acinetobacter baumannii NM8, activity value is MIC = 10 uM||Anti-Acinetobacter baumannii NM35, activity value is MIC = 5 uM||Anti-Stenotrophomonas maltophilia B32/1, activity value is MIC = 5 uM||Anti-Stenotrophomonas maltophilia B5/5, activity value is MIC = 10 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 80 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 10 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 80 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 40 uM||Anti-Human lung carcinoma A549, activity value is IC50 = 7.2||Anti-Human breast adenocarcinoma MDA-MB-231, activity value is IC50 = 20||Anti-Human colon adenocarcinoma HT29, activity value is IC50 = 35||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-diabetes||Hemolytic skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Pseudhymenochirus merlini|||skin secretions of the frog Pseudhymenochirus merlini (Pipidae) Helix skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Human umbilical vein endothelial cells HUVEC (50% Cell death at 5.6+-0.9 uM, Human erythrocytes (50% Hemolysis at 28+-2 uM, Mouse erythrocytes (50% Hemolysis at 30+-5 uM, Human umbilical vein endothelial cells HUVEC (50% Cell death at 27+-3 uM|||Human red blood cells (RBC): LC50>403 uM|||moderate hemolytic (LC50 28 uM) "Conlon JM, Prajeep M, Mechkarska M, Coquet L, Leprince J, Jouenne T, Vaudry H, King JD.2013 Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med|||24212286, 25447194, 26606380|||Comp Biochem Physiol Part D Genomics Proteomics . 2013 Dec;8(4):352-7. doi: 10.1016/j.cbd.2013.10.002. Epub 2013 Oct 12.|||Regul Pept. 2014 Nov;194-195:69-76.|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357.Pub-Med" 29 FPDB00317 AP02309|||AP02309|||Hymenochirin-1Pa|||Hymenochirin-1Pa|||AP02309|||DRAMP31853 LKLSPKTKDTLKKVLKGAIKGAIAIASMA Anti-S. maltophilia, activity value is MIC = 0.6||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 10 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 20 uM||Anti-and weakly against C. albicans, activity value is MIC = 80 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2.5 uM||Anti-Escherichia coli ATCC 25726, activity value is MIC = 10 uM||Anti-Staphylococcus aureus 145/08, activity value is MIC = 2.5 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 1.25 uM||Anti-Staphylococcus epidermidis RP62A/1, activity value is MIC = 1.25 uM||Anti-Staphylococcus epidermidis T6/19, activity value is MIC = 1.25 uM||Anti-Staphylococcus epidermidis T37/8, activity value is MIC = 1.25 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 20 uM||Anti-Escherichia coli ATCC 25726, activity value is MIC = 5 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 10 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 20 uM||Anti-Acinetobacter baumannii NM8, activity value is MIC = 5 uM||Anti-Acinetobacter baumannii NM35, activity value is MIC = 5 uM||Anti-Acinetobacter baumannii NM75, activity value is MIC = 2.5 uM||Anti-Acinetobacter baumannii NM109, activity value is MIC = 5 uM||Anti-Acinetobacter baumannii NM124, activity value is MIC = 2.5 uM||Anti-Stenotrophomonas maltophilia B32/1, activity value is MIC = 2.5 uM||Anti-Stenotrophomonas maltophilia B32/4, activity value is MIC = 1.25 uM||Anti-Stenotrophomonas maltophilia U8908, activity value is MIC = 5 uM||Anti-Stenotrophomonas maltophilia B5/5, activity value is MIC = 2.5 uM||Anti-Stenotrophomonas maltophilia B6/2, activity value is MIC = 1.25 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 80 uM||Anti-Human lung carcinoma A549, activity value is IC50 = 1.2||Anti-Human breast adenocarcinoma MDA-MB-231, activity value is IC50 = 3.1||Anti-Human colon adenocarcinoma HT29, activity value is IC50 = 12.3||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Pseudhymenochirus merlini|||Pseudhymenochirus merlini|||skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||skin secretions of the frog Pseudhymenochirus merlini (Pipidae) Helix skin secretions, Merlin's clawed frog, Pseudhymenochirus merlini, Africa|||Human umbilical vein endothelial cells HUVEC (IC50 at 7.7+-0.7 uM, Human erythrocytes (50% Hemolysis at 162+-13 uM|||Human umbilical vein endothelial cells HUVEC (IC50 at 7.7+-0.7 uM, Human erythrocytes (50% Hemolysis at 162+-13 uM|||Human red blood cells (RBC): LC50=162±13 uM "Conlon JM, Prajeep M, Mechkarska M, Coquet L, Leprince J, Jouenne T, Vaudry H, King JD.2013 Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357. Pub-Med|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357. Pub-Med|||24212286, 25241629|||24212286, 25241629|||Comp Biochem Physiol Part D Genomics Proteomics . 2013 Dec;8(4):352-7. doi: 10.1016/j.cbd.2013.10.002. Epub 2013 Oct 12.|||Peptides. 2014 Nov;61:114-21.|||Comp Biochem Physiol Part D Genomics Proteomics. 2013 Oct 12;8(4):352-357. Pub-Med" 29 FPDB00318 AP00566|||AP00566|||Dybowskin-3 , Brevinin-2DYc|||Dybowskin-3 , Brevinin-2DYc|||AP00566|||DRAMP01250 GLFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||Anti-M. luteus, activity value is MIC = 1.9 uM||Anti-v/v). The same amino acid sequence was also found by Conlon JM et al. as Brevinin-2DYc from Rana dybowskii (Brevinin-2DYc/d is active against E. coli and S. aureus, activity value is MIC = 15 uM||Anti-and S. lactis, activity value is MIC = 37.5 uM||Anti-C. albicans, activity value is MIC = 50 uM||Antibacterial||Anti-M. luteus, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 30 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 50 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 60 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 60 ug/ml||Anti-Escherichia coli, activity value is MIC = 15 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 15 ug/ml||Anti-Candida albicans, activity value is MIC = 100 ug/ml||Anti-S. aureus, activity value is MIC = 9 uM||Anti-B. subtilis, activity value is MIC = 15.1 uM||Anti-S. epidermidis, activity value is MIC = 18.1 uM||Anti-S. dysenteriae, activity value is MIC = 18.1 uM||Anti-E. coli, activity value is MIC = 4.5 uM||Anti-K. pneumoniae, activity value is MIC = 4.5 uM||Anti-P.mirabilis, activity value is MIC > 100 ug/ml||Anti-P.aeruginosa, activity value is MIC > 100 ug/ml||Anti-and C. albicans, activity value is MIC = 100 ug/ml||Anti-B. cereus, activity value is MIC = 37.5 uM||Anti-Micrococcus luteus ATCC4698, activity value is MIC = 39 ug/ml||Anti-Staphylococcus aureus KCTC3881, activity value is MIC = 50 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 60 ug/ml||Anti-Staphylococcus epidermidis ATCC12228, activity value is MIC = 60 ug/ml||Anti-Shigella dysenteriae ATCC9752, activity value is MIC = 15 ug/ml||Anti-Escherichia coli KCTC2433, activity value is MIC = 15 ug/ml||Anti-Klebsiella pneumoniae ATCC10031, activity value is MIC > 100 ug/ml||Anti-Candida albicans ATCC36232, activity value is MIC = 100 ug/ml Rana dybowskii, or Rana nigromaculata, Asia|||Rana dybowskii, or Rana nigromaculata, Asia|||Rana dybowskii [Dybovsky frog]|||Rana dybowskii [Dybovsky frog]|||Rana dybowskii, or Rana nigromaculata, Asia|||Rana dybowskii (Korea brown frog) N/A "Percent hemolysis 1.86%|||The document mentions hemolysis-related information; the specific hemolysis values are as follows: -Dybowskin-1: Hemolysis rate is 0.99%. -Dybowskin-2: Hemolysis rate is 10.99%. -Dybowskin-3: Hemolysis rate is 1.86%. -Dybowskin-4: Hemolysis rate is 47.58%. -Dybowskin-5: Hemolysis rate is 17.84%. -Dybowskin-6: Hemolysis rate is 59.41%.|||hRBC (1.86% hemolysis at 100 ug/ml)|||hRBC (1.86% hemolysis at 100 ug/ml)|||At the test concentration of 100 ug/ml, the hemolysis rate of Dybowskin-3 on human red blood cells is only 1.86%.|||[Ref:17698251] It has 1.86% hemolytic activity at 100 ug/ml against human red blood cells|||Showed ~50% hemolysis at (100 ug/ml peptide to 2% human RBCs, v/v)." "Peptides 2007; 28: 1532-1539. PubMed.|||Peptides . 2007 Aug;28(8):1532-9. doi: 10.1016/j.peptides.2007.07.002. Epub 2007 Jul 7.|||17698251 , 17688900|||17698251 , 17688900|||Peptides 2007; 28: 1532-1539. PubMed.|||Ref.17698251|||Peptides 2007; 28: 1532-1539. PubMed." 33 FPDB00319 AP00601|||AP00601|||Brevinin-1DYa|||Amurin-2c|||Amurin-2c|||AP00601|||DRAMP02016 FLSLALAALPKFLCLVFKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer||Anti-E. coli and S. aureus, activity value is MIC < 15 uM||Anti-C. albicans, activity value is MIC = 32 uM||Antibacterial ; Rana dybowskii [Dybovsky frog]||Antibacterial||Anti-S. aureus, activity value is MIC = 32 uM||Anti-E. coli, activity value is MIC > 512 uM||Anti-MRSA, activity value is MIC = 32 uM||Antimicrobial||Anti-Gram+||Anti-Gram- Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii [Dybovsky frog]|||Synthetic construct|||Rana dybowskii (Dybovsky's frog) (Korean brown frog) Helix "strongly hemolytic LC50<5 uM|||The document only explicitly provides the hemolytic values of three brevinin-1 family peptides in the skin extract of the Japanese brown frog (Rana dybowskii) (expressed as the concentration LC_{50} causing 50% hemolysis of human red blood cells), with the specific data as follows: Brevinin-1DYa: hemolytic value LC_{50} < 5 μM, minimum inhibitory concentration (MIC) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) both < 15 μM; Brevinin-1DYb: hemolytic value LC_{50} < 5 μM, MIC against E. coli and S. aureus both < 15 μM; Brevinin-1DYc: hemolytic value LC_{50} < 5 μM, MIC against E. coli and S. aureus both < 15 μM. In addition, the document also mentioned the following information: Brevinin-1DYd and Brevinin-1DYe were not accurately measured for hemolytic values due to their low content; Brevinin-2 family peptides Brevinin-2DYb, Brevinin-2DYc/d, and Brevinin-2DYe were only tested for antibacterial activity (MIC against E. coli and S. aureus: 15–30 μM) and no hemolytic values were reported; Temporin-1DYa, lacking the basic amino acid residues common to the temporin family, showed no or very weak hemolytic activity against red blood cells, and no specific LC_{50} value was provided.|||The document mentions that peptides of the brevinin-1 family have strong hemolytic activity against human red blood cells, with a half-hemolysis concentration (LC₅₀) of less than 5 µM.|||Horse RBC (HC50 = 17 uM)|||Horse RBC (HC50 = 17 uM)|||LC₅₀<5 uM" "Toxicon 2007; 50: 746-756. PubMed.|||Toxicon 2007; 50: 746-756. PubMed.|||Toxicon . 2007 Nov;50(6):746-56. doi: 10.1016/j.toxicon.2007.06.023. Epub 2007 Jul 4.|||https://pubmed.ncbi.nlm.nih.gov/17688900|||29366784|||29366784|||Toxicon 2007; 50: 746-756. PubMed.|||Toxicon. 2007 Nov;50(6):746-756." 20 FPDB00320 AP00602|||AP00602|||Brevinin-1DYb|||Amurin|||Amurin|||AP00602|||DRAMP02018 FLSLALAALPKLFCLIFKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer||Anti-E. coli and S. aureus MRSA, activity value is MIC = 15||Anti-inactive E.coli, activity value is MIC > 512 uM||Antibacterial ; Rana dybowskii [Dybovsky frog]||Antibacterial||Anti-S. aureus, activity value is MIC = 32 uM||Anti-E. coli, activity value is MIC > 512 uM||Anti-C. albicans, activity value is MIC = 32 uM||Anti-MRSA, activity value is MIC = 32 uM||Antimicrobial||Anti-Gram+||Anti-Gram- Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii, or Rana amurensis, Asia|||Rana dybowskii [Dybovsky frog]|||Synthetic construct|||Rana dybowskii (Dybovsky's frog) (Korean brown frog) Helix "strongly hemolytic LC50<5 uM|||The document only explicitly provides the hemolytic values of three brevinin-1 family peptides in the skin extract of the Japanese brown frog (Rana dybowskii) (expressed as the concentration LC_{50} causing 50% hemolysis of human red blood cells), with the specific data as follows: Brevinin-1DYa: hemolytic value LC_{50} < 5 μM, minimum inhibitory concentration (MIC) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) both < 15 μM; Brevinin-1DYb: hemolytic value LC_{50} < 5 μM, MIC against E. coli and S. aureus both < 15 μM; Brevinin-1DYc: hemolytic value LC_{50} < 5 μM, MIC against E. coli and S. aureus both < 15 μM. In addition, the document also mentioned the following information: Brevinin-1DYd and Brevinin-1DYe were not accurately measured for hemolytic values due to their low content; Brevinin-2 family peptides Brevinin-2DYb, Brevinin-2DYc/d, and Brevinin-2DYe were only tested for antibacterial activity (MIC against E. coli and S. aureus: 15–30 μM) and no hemolytic values were reported; Temporin-1DYa, lacking the basic amino acid residues common to the temporin family, showed no or very weak hemolytic activity against red blood cells, and no specific LC_{50} value was provided.|||The document mentions that peptides of the brevinin-1 family exhibit strong hemolytic activity against human red blood cells, with a half-maximal hemolytic concentration (LC₅₀) of less than 6 µM.|||Horse RBC (HC50 = 4.7 uM)|||Horse RBC (HC50 = 4.7 uM)|||LC₅₀<5 uM" "Toxicon 2007; 50: 746-756. PubMed|||Toxicon 2007; 50: 746-756. PubMed.|||Toxicon . 2007 Nov;50(6):746-56. doi: 10.1016/j.toxicon.2007.06.023. Epub 2007 Jul 4.|||https://pubmed.ncbi.nlm.nih.gov/17688900|||29366784|||29366784|||Toxicon 2007; 50: 746-756. PubMed.|||Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.Toxicon. 2007 Nov;50(6):746-756." 20 FPDB00324 AP00723|||AP00723|||Decoralin|||DRAMP03056|||Decoralin|||AP00723 SLLSLIRKLIT Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anticancer||Anti-negative E. coli ATCC 25922, activity value is MIC = 80 uM||Anti-and A. faecalis ATCC 8750, activity value is MIC = 40 uM||Anti-and yeast C. albicans . It only showed weak leishmanicidal activity, activity value is IC50 = 72 uM||Anti-Staphylococcus aureus NCTC 10571, activity value is MIC = 14 uM||Anti-Escherichia coli NCTC 8007, activity value is MIC = 297 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 579 uM||Anti-Acinetobacter sp, activity value is MIC = 0.86 uM||Anti-Enterobacter aerogenes, activity value is MIC = 290 uM||Anti-Klebsiella sp. Strain 3105, activity value is MIC = 290 uM||Anti-Providencia stuartii, activity value is MIC > 1000 uM||Anti-Proteus mirabilis, activity value is MIC > 1000 uM||Anti-Fungi: Botrytis cinerea, activity value is MIC = 0.5 ug/ml||Anti-Candida albicans, activity value is MIC = 100 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-S.aureus CCT 6538, activity value is MIC = 40 uM||Anti-S.saprophyticus, activity value is MIC = 40 uM||Anti-B.subtilis CCT 2471, activity value is MIC = 40 uM||Anti-B.thuringiensis, activity value is MIC = 40 uM||Anti-E.coli ATCC 25922, activity value is MIC = 80 uM||Anti-E.coli CCT 1371, activity value is MIC = 160 uM||Anti-K.pneumonia ATCC 13883, activity value is MIC = 80 uM||Anti-A.faecalis ATCC 8750, activity value is MIC = 40 uM||Anti-C.albicans, activity value is MIC = 40 uM||Anti-L.major promastigotes, activity value is IC50 = 72 uM||Anti-28105725 :Candida albicans, activity value is MIC = 6.25 uM||Anti-28795464: Micrococcus luteus A 270, activity value is MIC = 0.8 uM||Anti-Escherichia coli SBS 363, activity value is MIC = 1.6 uM||Anti-Salmonella arizonae ATCC 13314, activity value is MIC = 25 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 6.2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1.6 uM||Anti-Candida albicans MDM8, activity value is MIC = 0.8 uM venom, solitary eumenine wasp, Oreumenes decoratus|||venom, solitary eumenine wasp, Oreumenes decoratus|||Synthetic construct|||Oreumenes decoratus (Potter wasp)|||Oreumenes decoratus|||venom, solitary eumenine wasp, Oreumenes decoratus, China, Asia|||venom, solitary eumenine wasp, Oreumenes decoratus, China, Asia Helix significant hemolytic activity|||EC₅₀=1000 uM "Peptides. 2007 Dec;28(12):2320-7. Epub 2007 Sep 29. PubMed|||Peptides . 2007 Dec;28(12):2320-7. doi: 10.1016/j.peptides.2007.09.017. Epub 2007 Sep 29.||Torres et al., 2018|||17981364, 28105725, 28795464||Refer PubMed ID 9596699||Refer PubMed ID 15155221|||Peptides. 2007 Dec;28(12):2320-2327.|||https://pubmed.ncbi.nlm.nih.gov/17981364,|||Peptides. 2007 Dec;28(12):2320-7. Epub 2007 Sep 29. PubMed.||Torres et al., 2018|||Peptides. 2007 Dec;28(12):2320-7. Epub 2007 Sep 29. PubMed." 11 FPDB00326 AP00779|||4511|||4512|||4513|||4514|||4515|||4516|||4517|||4518|||4519|||4520|||4521|||4522|||4523|||4524|||4525|||4526|||4527|||4528|||4529|||4530|||4531|||4570|||4573|||AP00779|||Winter flounder 1a1|||DRAMP02349|||Winter flounder 1a1|||AP00779 GRRKRKWLRRIGKGVKIIGGAALDHL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anticancer||5% cytotoxic at 5 uM||5% cytotoxic at 10 uM||30-35% cytotoxic at 25 uM||60% cytotoxic at 50 uM||5-10% cytotoxic at 5 uM||10% cytotoxic at 10 uM||30% cytotoxic at 5 uM||50% cytotoxic at 10 uM||70% cytotoxic at 25 uM||80-85% cytotoxic at 50 uM||40-50% cytotoxic at 10 uM||60-70% cytotoxic at 25 uM||15-20% cytotoxic at 5 uM||80% cytotoxic at 25 uM||85-90% cytotoxic at 50 uM||~0% cytotoxic at 5 uM||70% cytotoxic at 50 uM||60-70% cytotoxic at 50 uM||Anti-A. salmonicida 99-1, activity value is MIC = 2 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 4 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-E. coli CGSC 4908, activity value is MIC = 2 ug/ml||Anti-E. coli UB1005, activity value is MIC = 8 ug/ml||Anti-E. coli DC2, activity value is MIC = 2 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 8 ug/ml||Anti-MRSA C623, activity value is MIC = 8 ug/ml||Anti-C. albicans C627, activity value is MIC = 4 ug/ml||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 2 ug/ml||Anti-Aeromonas salmonicida 97-4, activity value is MIC = 4 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-Salmonella enterica serovar Typhimurium 14028s, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 2 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 2 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 8 ug/ml||Anti-Escherichia coli DC2, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus C623, activity value is MIC = 8 ug/ml||Anti-Highly active against active against A. salmonicida 99-1, activity value is MIC = 2 uM||Anti-A. salmonicida 97-4, activity value is MIC = 4 uM||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 uM||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 uM||Anti-P. aeruginosa K799, activity value is MIC = 2 uM||Anti-P. aeruginosa Z61, activity value is MIC = 1 uM||Anti-E. coli CGSC4908 or UB1005 or DC2, activity value is MIC = 2||Anti-S. epidermidis C621, activity value is MIC = 8 uM||Anti-methicillin-resistant S. aureus C623 MRSA, activity value is MIC = 8 uM||Anti-C. albicans C627, activity value is MIC = 4 uM winter flounder 1a-1, Pleuronectes americanus|||winter flounder 1a-1, Pleuronectes americanus|||winter flounder 1a-1, Pleuronectes americanus|||Pseudopleuronectes americanus [Winter flounder]|||Pseudopleuronectes americanus (Winter flounder 3)|||Pseudopleuronectes americanus [Winter flounder]|||winter flounder 1a-1, Pleuronectes americanus N/A N/A Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.||Hou et al., 2022 26 L FPDB00328 AP00793|||AP00793|||Bombinin H4 LIGPVLGLVGSALGGLLKKI Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Hemolytic||Anticancer||Antibacterial ; Bombina variegata [Yellow-bellied toad]||Antibacterial||Anti-C. tropicalis . Also active against C. jeikeium ATCC BAA-949, activity value is MIC = 8 uM Bombina variegata, Europe|||Bombina variegata, Europe|||Bombina variegata [Yellow-bellied toad] Helix Bombinin H1: Not detected Bombinin H3: 15.7 µM Bombinin H4: 14.6 µM Bombinin H5: Not detected Synthetic peptide B: 17 µM|||Hemolytic activity (Human red blood cells) = 14.6 uM EMBO J. 1993; 12:4829-4832|||EMBO J. 1993; 12:4829-4832|||https://pubmed.ncbi.nlm.nih.gov/8223491|||EMBO J. 1993; 12:4829-4832||Mangoni ML et al. 2007 20 FPDB00331 AP00819|||AP00819|||Temporin-1Oc1|||DRAMP01773 " FLPLLASLFSRLF" Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anticancer||Anti-S. aureus, activity value is MIC = 2 uM||Anti-Staphylococcus epidermidis 1457, activity value is MIC = 1.6 uM||Anti-Bacillus subtilis 168, activity value is MIC = 12.5 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 25 uM||Anti-C. glabrata ATCC 2001, activity value is MIC = 25 uM||Anti-C. tropicalis ATCC 13803, activity value is MIC = 1.6||Anti-S. epidermidis 1457, activity value is MIC = 1.6 uM||Anti-B. subtilis 168, activity value is MIC = 12.5 uM||Anti-C. albicans, activity value is MIC = 25 uM||Anti-C. glabrata, activity value is MIC = 25 uM||Anti-Staphylococcus aureus, activity value is MIC = 2 uM Rana Ornativentris, Asia|||Rana Ornativentris, Asia|||Rana ornativentris|||Rana ornativentris (Japanese mountain brown frog) N/A Human RBCs (HL50 < 12.5 uM) J Peptide Res 2001; 58: 349-356. PubMed|||J Peptide Res 2001; 58: 349-356. PubMed.|||2001 Nov;58(5):349-56. doi: 10.1034/j.1399-3011.2001.00947.x.|||17147973, 11892844, 29842923||Refer PubMed ID: 29842923|||J Peptide Res 2001; 58: 349-356. PubMed.||see ref 13 FPDB00332 AP00832|||AP00832|||Maximin H1|||DRAMP01123|||Maximin H1|||AP00832|||DRAMP01123 " ILGPVISTIGGVLGGLLKNL" Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anticancer||Antibacterial ; Bombina maxima [Giant fire-bellied toad]||Anti-Escherichia coli ATCC25922, activity value is MIC = 9 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 4.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 9 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 4.5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 9 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 4.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 1010, activity value is MIC = 9 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 9 ug/ml||Anti-and fungi C. albicans ATCC2002, activity value is MIC = 4.5 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- skin secretions, Bombina maxima, China, Asia|||skin secretions, Bombina maxima, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||skin secretions, Bombina maxima, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||skin secretions, Bombina maxima, China, Asia N/A "strongly hemolytic|||Maximins: At peptide concentrations up to 50 µg/ml, maximins peptides showed almost no hemolytic activity. Maximin H peptide: At a concentration of 50 µg/ml, all maximin H peptides were able to lyse 90-100% of rabbit red blood cells.|||Escherichia coli ATCC25922 ( MIC = 9 ug/ml ), Staphylococcus aureus ATCC2592 ( MIC = 4.5 ug/ml ), Bacillus pyocyaneus CMCCB1010 ( MIC = 9 ug/ml ), Candida albicans ATCC2002 ( MIC = 4.5 ug/ml )|||The document mentions information related to the hemolytic activity of antimicrobial peptides in the skin secretions of the large-webbed bell toad (Bombina maxima): - Maxims (first group of peptides): Even at concentrations as high as 50 µg/ml, they show almost no hemolytic activity against red blood cells. - Maxims H (second group of peptides): They have strong hemolytic activity, causing 90%-100% hemolysis of rabbit red blood cells at a concentration of 50 µg/ml. In the experiments, the group treated with 1% Triton X-100 was used as the maximum hemolysis control, and the degree of hemolysis was assessed by measuring the absorbance at 595 nm. The results showed that maximins H peptides have a significantly stronger hemolytic effect on red blood cells than maximins." Peptides 2002; 23: 427-435|||Peptides 2002; 23: 427-435|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23: 427-435||Lai R et al., 2012|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435. 20 FPDB00333 AP00861|||AP00861|||Amolopin-1b|||DRAMP01341|||Amolopin-1b|||AP00861|||DRAMP01341 " FLPLAVSLAANFLPKLFCKITKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 5.5 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 2.2 ug/ml||Anti-Escherichia coli, activity value is MIC = 6.5 ug/ml||Anti-Candida albicans, activity value is MIC = 7.5 ug/ml||Anti-Gram+ S. aureus, activity value is MIC = 5.5 ug/ml||Anti-B. dysenteriae, activity value is MIC = 2.2||Anti-and fungi C. albicans, activity value is MIC = 7.5 ug/ml Amolops loloensis, China, Asia|||Amolops loloensis, China, Asia|||Amolops loloensis [rufous-spotted torrent frog]|||Amolops loloensis (Rufous-spotted torrent frog)|||Amolops loloensis [rufous-spotted torrent frog]|||Amolops loloensis, China, Asia|||Amolops loloensis (Rufous-spotted torrent frog) N/A strong hemolytic activity with a LD50 of 5000 ug/ml|||Brevinins-ALb: 5 µg/ml Temporins-ALa: None|||Staphylococcus aureus ( MIC = 5.5 ug/ml ), Escherichia coli ( MIC = 6.5 ug/ml ), Bacillus dysenteriae ( MIC = 2.2 ug/ml ), Candida albicans ( MIC = 7.5 ug/ml ) Peptides 2006; 27: 3085-3091|||Peptides 2006; 27: 3085-3091|||17000029|||Peptides. 2006 Dec;27(12):3085-3091.|||17000029|||Peptides 2006; 27: 3085-3091 24 FPDB00334 AP00863|||AP00863|||Temporins-ALa|||DRAMP01339|||Temporins-ALa|||AP00863|||DRAMP01339 FLPIVGKLLSGLSGLL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||Anti-S. aureus, activity value is MIC = 2 ug/ml||Anti-E. coli, activity value is MIC = 3 ug/ml||Anti-B. dysenteriae, activity value is MIC = 1.5 ug/ml||Anti-C. albicans, activity value is MIC = 6.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 2 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 1.5 ug/ml||Anti-Escherichia coli, activity value is MIC = 3 ug/ml||Antibacterial||Anti-Gram+ S. aureus, activity value is MIC = 2 ug/ml||Anti-B. dysenteriae, activity value is MIC = 1.5||Anti-and fungi C. albicans, activity value is MIC = 6.5 ug/ml the rufous-spotted torrent frog, Amolops loloensis, China, Asia|||the rufous-spotted torrent frog, Amolops loloensis, China, Asia|||Amolops loloensis|||Amolops loloensis (Rufous-spotted torrent frog)|||Amolops loloensis [Rufous-spotted torrent frog]|||the rufous-spotted torrent frog, Amolops loloensis, China, Asia|||Amolops loloensis (Rufous-spotted torrent frog) N/A had little hemolytic activity|||Brevinins-ALb: 5 µg/ml Temporins-ALa: None|||Rabbit red blood cells (Slight hemolysis observed)|||In the study of antimicrobial peptides from the skin of the brown-spotted torrent frog, rabbit red blood cells were used as the test subject. The half-maximal hemolytic concentration (LD₅₀) of Brevinins-ALb was 5 μg/ml, and at a concentration of 20 μg/ml, it could lyse 96% of rabbit red blood cells, whereas Temporins-ALa showed almost no hemolytic activity.|||Rabbit red blood cells (Slight hemolysis observed) Peptides 2006; 27: 3085-3091|||Peptides 2006; 27: 3085-3091|||17000029|||Peptides. 2006 Dec;27(12):3085-3091.|||17000029|||Peptides 2006; 27: 3085-3091 16 FPDB00335 AP00871|||DRAMP01793 " FLPFLKSILGKIL" Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anticancer||Anti-Antibacterial activity was not reported due to a limited amount of material. We filled up this gap by using a synthetic peptide. Active against S. aureus USA300, activity value is MIC = 1.6||Anti-S. epidermidis 1457, activity value is MIC = 1.6 uM||Anti-B. subtilis 168, activity value is MIC = 12.5||Anti-C. albicans, activity value is MIC = 12.5 uM||Anti-C. glabrata, activity value is MIC = 12.5 uM||Antimicrobial Florida bog frog, Rana okaloosae, North America|||Rana okaloosae (Florida bog frog) Helix N/A Regul Pept 2007; 138: 87-93. PubMed|||Regul Pept 2007; 138: 87-93. PubMed.|||2007 Feb 1;138(2-3):87-93. doi: 10.1016/j.regpep.2006.08.007. Epub 2006 Sep 26.|||Regul Pept 2007; 138: 87-93. 13 FPDB00336 AP00878|||AP00878|||Brevinin-1BYa|||DRAMP01960|||Brevinin-1BYa|||AP00878|||DRAMP01960 " FLPILASLAAKFGPKLFCLVTKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-V3577, activity value is MIC = 3||Anti-V65A, activity value is MIC = 5||Anti-B51a/5, activity value is MIC = 5 uM||Anti-4426, activity value is MIC = 5||Anti-also Gram- E. coli ATCC 25922, activity value is MIC = 17||Anti-K. pneumoniae KK3 9904, activity value is MIC = 40 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 10 uM||Anti-P.mirabilis, activity value is MIC > 40 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 5 uM||Anti-Streptococcus Group B HNTCC 80130, activity value is MIC = 10 uM||Anti-S. epidermidis RP62A, activity value is MIC = 5 uM||Anti-and S. aureus NCTC 8352, activity value is MIC = 2 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 2 uM||Anti-Escherichia coli, activity value is MIC = 17 uM||Anti-Candida albicans, activity value is MIC = 3 uM||Antimicrobial||Anti-Gram+||Anti-Gram- skin secretions, the foothill yellow-legged frog, Rana boylii, North America|||skin secretions, the foothill yellow-legged frog, Rana boylii, North America|||Rana boylii [Foothill yellow-legged frog]|||Rana boylii (Foothill yellow-legged frog)|||Rana boylii [Foothill yellow-legged frog]|||skin secretions, the foothill yellow-legged frog, Rana boylii, North America|||Rana picturata (Malaysian fire frog) (Hylarana picturata) Helix strong haemolytic LD50 =10 uM|||Brevinin-1BYa：LD₅₀ = 10 uM[Ser¹⁸,Ser²⁴] Brevinin-1BYa：LD₅₀ = 80 uM|||It is highly hemolytic (HC50 = 4-10 uM). Int J Antimicrob Agents 2006; 27: 525-529|||Int J Antimicrob Agents 2006; 27: 525-529|||14531844|||J Pept Res. 2003 Nov;62(5):207-213.||Ref.14531844|||14531844|||Int J Antimicrob Agents 2006; 27: 525-529|||Toxicon. 2008 Sep 1;52(3):465-473. 24 FPDB00337 AP00952|||1425|||1794|||1946|||2098|||2250|||2545|||2688|||AP00952|||MSI-78|||Pexiganan|||MSI-78, MSIEP GIGKFLKKAKKFGKAFVKILKK Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-inflammatory||Wound healing||Anticancer||75% Cytotoxicity at 0.5 ug/ml||activity value is LD50 = 31 ug/ml||activity value is LD50 = 34 ug/ml||activity value is LD50 = 140 ug/ml||activity value is LD50 = 66 ug/ml||Anti-91% were susceptible to MSI-78 tested at a break-point of 64 ug/ml . Active against Acinetobacter sp. 10 strains, activity value is MIC = 4||Anti-A. faecalis 5 strains, activity value is MIC = 4||Anti-C. diversus 10 strains, activity value is MIC = 8||Anti-C. freundii 25 strains, activity value is MIC = 8||Anti-C. jeikeium, activity value is MIC = 0.125||Anti-E. aerogenes 25 strains, activity value is MIC = 8||Anti-E. cloacae 25 strains, activity value is MIC = 1||Anti-E.faecalis 30 strains, activity value is MIC > 256 ug/ml||Anti-E. coli 30 strains, activity value is MIC = 8||Anti-K. oxytoca 10 strains, activity value is MIC = 8||Anti-K. pneumoniae 25 strains, activity value is MIC = 8||Anti-P. aeruginosa 25 strains, activity value is MIC = 8||Anti-P. fluorescens 5 strains, activity value is MIC = 2||Anti-P. stutzeri 5 strains, activity value is MIC = 4||Anti-S. aureus MRSA 10 strains, activity value is MIC = 16||Anti-S. aureus MSSA 15 strains, activity value is MIC = 0.125||Anti-S. epidermidis 25 strains, activity value is MIC = 0.125||Anti-S. haemolyticus 10 strains, activity value is MIC = 408 ug/ml||Anti-S. hominis 5 strains, activity value is MIC = 2||Anti-S. simulans 5 strains, activity value is MIC = 0.125||Anti-S. warneri 5 strains, activity value is MIC = 0.125||Anti-S. xylosus 1 strain, activity value is MIC = 0.125 ug/ml||Anti-S. maltophilia 10 strains, activity value is MIC = 4||Anti-S. agalactiae 25 strains, activity value is MIC = 16||Anti-S. bovis 5 strains, activity value is MIC = 8||Anti-S. equinus 2 strains, activity value is MIC = 2||Anti-S. pyogenes 30 strains, activity value is MIC = 16||Anti-Streptococcus group C 5 strains, activity value is MIC = 16||Anti-Streptococcus group G 5 strains, activity value is MIC = 16||Anti-Viridans group streptococci 13 strains, activity value is MIC = 4||Anti-B. ovatus 7 strains, activity value is MIC = 4||Anti-B. ureolyticus 3 strains, activity value is MIC = 0.25||Anti-B. vulgatus 6 strains, activity value is MIC = 4 ug/ml||Anti-C. difficile 4 strains, activity value is MIC = 0.5||Anti-C. perfringens 5 strains, activity value is MIC = 8||Anti-C. ramosum 2 strains, activity value is MIC = 16 ug/ml||Anti-C. sporogenes 2 strains, activity value is MIC = 8||Anti-Clostridium sp, activity value is MIC = 32 ug/ml||Anti-P. anaerobius 6 strains, activity value is MIC = 32||Anti-P. asaccharolyticus 3 strains, activity value is MIC = 4||Anti-P. magnus 4 strains, activity value is MIC = 0.5||Anti-P. bivia 9 strains, activity value is MIC = 32||Anti-and P. melaninogenica 3 strains, activity value is MIC = 32||MIC against MRSA Staphylococcus aureus CCARM 3696||Bacillus subtilis KCTC 2213||Micrococcus luteus KCTC9341||vancomycin-resistant Enterococcus faecium CCARM 5028 (VRE)||Listeria mono-cytogenes KCTC 19111||multidrug-resistant Pseudomonas aeruginosa CCARM 2161(MDRPA)||Escherichia coli KCTC 1039||Klebsiella oxytoca KCTC 1686||Citrobacter fre-undii KCTC 2359 and Salmonella enterica KCTC 2930||Antibacterial amino acid substitution, amphibians, animal-derived, natural derivative|||amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct Helix Staphylococcus aureus ATCC 29213 ( MIC = 8 16 ug/ml ), Staphylococcus aureus ATCC 33591 (methicillin resistant) ( MIC = 16 32 ug/ml ), Staphylococcus epidermidis ATCC 12228 ( MIC = 2 4 ug/ml ), Enterococcus faecium ATCC 51559 (vancomycin resistant) ( MIC = 8 ug/ml ), Enterococcus faecalis ATCC 29212 ( MIC = 64 ug/ml ), Group A Streptococcus ATCC 49399 ( MIC = 4 ug/ml ), Streptococcus pneumoniae ATCC 49619 ( MIC = 32 ug/ml ), Streptococcus bovis ATCC 49133 ( MIC = 4 ug/ml ), Bacillus cereus ATCC 11778 ( MIC = 8 ug/ml ), Micrococcus luteus ATCC 4698 ( MIC = 2 ug/ml ), Corynebacterium group A ATCC 49676 ( MIC = 2 4 ug/ml ), Escherichia coli ATCC 25922 ( MIC = 8 16 ug/ml ), Enterobacter cloacae ATCC 35030 ( MIC = 8 ug/ml ), Proteus mirabilis ATCC 29245 ( MIC = >256 ug/ml ), Serratia marcescens ATCC 8100 ( MIC = >256 ug/ml ), Helicobacter pylori ATCC 43504 ( MIC = 2 ug/ml ), Haemophilus influenzae ATCC 49247 ( MIC = 8 ug/ml ), Pseudomonas aeruginosa ATCC 27853 ( MIC = 8 16 ug/ml ), Bacteroides fragilis ATCC 90028 ( MIC = 2 4 ug/ml ), Bacteroides thetaiotaomicron ATCC 29741 ( MIC = 2 4 ug/ml ), Clostridium difficile ATCC 43255 ( MIC = 4 ug/ml ), Propionibacterium acnes ATCC 29399 ( MIC = 8 ug/ml ), Veillonella parvula ATCC 10790 ( MIC = 8 ug/ml )|||A. baumannii ATCC 19606 (MIC =2 ug/ml)|||MSI-78, [P. aeruginosa (MIC = 0.78 uM), E. coli (MIC = 1.56-3.12 uM), S. aureus (MIC = 0.78-1.56 uM), B. subtilis (MIC = 1.56 uM)]; MSIEP [(Isopeptide formation: K8, K14, and K18) - P. aeruginosa (MIC = 6.25-12.5 uM), E. coli (MIC = 12.5 uM), S. aureus (MIC = 6.25-12.5 uM), B. subtilis (MIC = 6.25-12.5 uM)]|||Even at a concentration of 200 ug/ml, the hemolysis rate of this peptide on human red blood cells remains < 1%.|||human RBC, 53% hemolysis at 512 ug/ml (HC50 512 ug/ml), less hemo.lytic. "Ciba Found Symp. 1994;186:197-216; discussion 216-23. doi: 10.1002/9780470514658.ch12. PubMed|||J Antimicrob Chemother . 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. Epub 2013 Aug 14.|||1994:186:197-216; discussion 216-23.doi: 10.1002/9780470514658.ch12.||Fucks et al., 1998|||10103181|||30043322|||34043312|||Ciba Found Symp. 1994;186:197-216; discussion 216-23. doi: 10.1002/9780470514658.ch12. PubMed.||Fucks et al., 1998|||Ciba Found Symp. 1994;186:197-216; discussion 216-23. doi: 10.1002/9780470514658.ch12. PubMed." 22 L FPDB00339 AP00973|||AP00973|||Phylloseptin-L1|||Phylloseptin-L1|||AP00973|||DRAMP31672 " LLGMIPLAISAISALSKL" Anti-Gram+||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-Phylloseptin-L1 was active against S. aureus, activity value is MIC = 8 uM||Anti-Batrachochytrium dendrobatidis, activity value is MIC = 100 uM||Anti-Staphylococcus aureus, activity value is MIC = 8 uM||Antimicrobial Hylomantis lemur (Hylidae: Phyllomedusinae, South America; also skin secretion, red-eyed leaf frog, Agalychnis callidryas, Central America|||Hylomantis lemur (Hylidae: Phyllomedusinae, South America; also skin secretion, red-eyed leaf frog, Agalychnis callidryas, Central America|||Hylomantis lemur, Agalychnis callidryas [Lemur leaf frog, Red-eyed tree frog]|||Hylomantis lemur (Hylidae: Phyllomedusinae, South America; also skin secretion, red-eyed leaf frog, Agalychnis callidryas, Central America|||skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae) N/A strongly hemolytic|||Dermaseptin-L1: Human red blood cells: LC₅₀ = 200 μMHepG2 human liver cancer cells: LC₅₀ = 45 μMPhylloseptin-L1: Human red blood cells: LC₅₀ = 40 μMHepG2 human liver cancer cells: LC₅₀ = 35 μM|||Human erythrocytes ( LC50 = 40 uM ), Human HepG2 cells ( LC50 = 35 uM )|||Human erythrocytes ( LC50 = 40 uM ), Human HepG2 cells ( LC50 = 35 uM )|||Human erythrocytes: LC50=200 uM Toxicon. 2007 Sep 15;50(4):498-506|||Toxicon. 2007 Sep 15;50(4):498-506|||17561225|||17561225|||Toxicon. 2007 Sep 15;50(4):498-506|||Toxicon. 2007 Sep 15;50(4):498-506. 18 FPDB00345 AP01036|||AP01036|||Cycloviolacin O2|||DRAMP00805 " GIPCGESCVWIPCISSAIGCSCKSKVCYRN" Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anticancer||Anti-S. enterica serovar Typhimurium LT2 and E. coli in RDAs and MIC assays . Moderately active against S. aureus, activity value is MIC = 20||Anti-and C. albicans . A. baumannii, activity value is MIC = 4.2 uM||Anti-plant fungi F. oxysporum, activity value is MIC = 6||Anti-B. cinerea, activity value is MIC = 1.5 uM||Anti-F. graminearum, activity value is MIC = 6.25 uM||Anti-F. culmorum, activity value is MIC = 1.5 uM||Anti-C. utrechtense, activity value is MIC = 6.25 uM||Anti-A. alternatam, activity value is MIC = 1.5 uM||Anti-Escherichia coli, activity value is MIC = 20 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 10 uM||Anti-Staphylococcus aureus, activity value is MIC = 20 uM||Anti-Candida albicans, activity value is MIC = 20 uM||Insecticidal Viola odorata and Viola japonica|||Viola odorata and Viola japonica|||Viola odorata L. and Viola tricolor L|||Viola biflora (Yellow wood violet) & Viola odorata (Sweet violet) Bridge||Combine helix and strand structure [Ref:16872274] It has 35% hemolytic activity at 1 uM and 60% hemolytic activity at 1.5 uM against human type A red blood cells J Mol Biol. 1999 Dec 17;294(5):1327-36. Pub-Med.|||1999 Dec 17;294(5):1327-36. doi: 10.1006/jmbi.1999.3383.||ref 2024||Pränting M et al., 2010||Fensterseifer IC et al., 2014||Strömstedt AA et al., 2017||Slazak et al. 2018|||28669767|||J Mol Biol. 1999 Dec 17;294(5):1327-36. Pub-Med.||ref 2024||Pränting M et al., 2010||Fensterseifer IC et al., 2014||Strömstedt AA et al., 2017||Slazak et al. 2018|||J Mol Biol. 1999 Dec 17;294(5):1327-36. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12.J Mol Biol. 1999 Dec 17;294(5):1327-1336.Biochem J . 2006 Nov 15;400(1):1-12. 30 FPDB00349 AP01161 GRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Chemotactic||anti-TB||anti-sepsis||Synergistic AMPs||Hemolytic||Anticancer||a recombinant peptide showed activity in vitro against bacteria (S. typhimurium||L. monocytogenes||E. coli||and S. aureus)||fungi C. neoformans||C. albicans||and parasites L. major||and parasites L. major. NK cells; T lymphocytes; Homo sapiens|||gammadelta T cells, NK cells; T lymphocytes; Homo sapiens|||gammadelta T cells, NK cells; T lymphocytes; Homo sapiens|||NK cells; T lymphocytes; Homo sapiens Helix . Eluted fractions were all individually assayed for hemolytic activity. The fractions with the highest hemolytic activity were pooled and concentrated for use. Science. 1998 Oct 2;282(5386):121-5. Pub-Med.|||1998 Oct 2;282(5386):121-5. doi: 10.1126/science.282.5386.121.||see the ref|||1998 Oct 2;282(5386):121-5. doi: 10.1126/science.282.5386.121.|||Science. 1998 Oct 2;282(5386):121-5. Pub-Med.||see the ref|||Science. 1998 Oct 2;282(5386):121-5. Pub-Med. 74 FPDB00351 AP01239|||Cathelicidin-BF antimicrobial peptide|||CWA|||DRAMP02473|||Cathelicidin-BF antimicrobial peptide|||AP01239|||BF-30 " KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF" Anti-Gram+ & Gram-||Antifungal||candidacidal||Enzyme inhibitor||Anticancer||Anti-Bacillus subtilis, activity value is MIC = 9.4 ug/ml||Anti-Bacillus pumilus, activity value is MIC = 9.4 ug/ml||Anti-Bacillus cereus, activity value is MIC = 1.2 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 1.2 ug/ml||Anti-DR, activity value is MIC = 2.3 ug/ml||Anti-DR, activity value is MIC = 9.4 ug/ml||Anti-DR, activity value is MIC = 18.7 ug/ml||Anti-Escherichia coliATCC25922, activity value is MIC = 2.3 ug/ml||Anti-DR, activity value is MIC = 1.2 ug/ml||Anti-DR, activity value is MIC = 0.6 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 4.7 ug/ml||Anti-DR, activity value is MIC = 75 ug/ml||Anti-Acinetobacter calcoaceticus, activity value is MIC = 2.3 ug/ml||Anti-Sphingobacterium siyangense, activity value is MIC = 9.4 ug/ml||Anti-Sacharibacillus kuerlensis, activity value is MIC = 4.7 ug/ml||Anti-Pseudomonas luteola, activity value is MIC = 1.2 ug/ml||Anti-DR, activity value is MIC = 4.7 ug/ml||Anti-DR, activity value is MIC = 0.3 ug/ml||Anti-DR, activity value is MIC = 150 ug/ml||Anti-Aspergillus terreus GIM3.34, activity value is MIC = 18.7 ug/ml||Anti-Aspergillus niculans, activity value is MIC = 18.7 ug/ml||Anti-Chaetomium globosum, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 4.7 ug/ml||Anti-Pichia pastoris, activity value is MIC = 0.3 ug/ml||E. coli K88||Anti-P. aeruginosa IS/DR, activity value is MIC = 2.3 ug/ml||Anti-P. aeruginosa 08031205 IS/DR, activity value is MIC = 9.4 ug/ml||Anti-P. aeruginosa 08031014 IS/DR, activity value is MIC = 18.7 ug/ml||Anti-Escherichia coli ATCC25922, activity value is MIC = 2.3 ug/ml||Anti-E. coli 08A852 IS/DR, activity value is MIC = 1.2 ug/ml||Anti-E. coli 08A866 IS/DR, activity value is MIC = 0.6 ug/ml||Anti-E. coli 08031017 IS/DR, activity value is MIC = 2.3 ug/ml||Anti-E. coli 08032813 IS/DR, activity value is MIC = 2.3 ug/ml||Anti-E. coli 08040726 IS/DR, activity value is MIC = 0.6 ug/ml||Anti-E. coli 08040722 IS/DR, activity value is MIC = 0.6 ug/ml||Anti-Klebsiella pneumoniae IS/DR, activity value is MIC = 4.7 ug/ml||Anti-K. pneumoniae 08031012 IS/DR, activity value is MIC = 9.4 ug/ml||Anti-K. pneumoniae 08040202 IS/DR, activity value is MIC = 0.6 ug/ml||Anti-K. pneumoniae 08040724 IS/DR, activity value is MIC = 0.3 ug/ml||Anti-Salmonella Typhi IS/DR, activity value is MIC = 1.2 ug/ml||Anti-Saccharibacillus kuerlensis, activity value is MIC = 4.7 ug/ml||Anti-B. pumilus, activity value is MIC = 9.4 ug/ml||Anti-B. cereus, activity value is MIC = 1.2 ug/ml||Anti-S. aureus 08A875 IS/DR, activity value is MIC = 75 ug/ml||Anti-S. aureus 08031002 IS/DR, activity value is MIC > 100 ug/ml||Anti-S. aureus 08031013 IS/DR, activity value is MIC > 100 ug/ml||Anti-S. aureus 08032706 IS/DR, activity value is MIC > 100 ug/ml||Anti-S. aureus 08032712 IS/DR, activity value is MIC > 100 ug/ml||Anti-S. aureus 08032810 IS/DR, activity value is MIC > 100 ug/ml||Anti-Enterococcus faecium IS/DR, activity value is MIC = 150 ug/ml||Anti-Aspergillus nidulans, activity value is MIC = 18.7 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 2.3 uM||Anti-P. aeruginosa ATCC278953, activity value is MIC = 1.2 uM||Anti-and C. albicans, activity value is MIC = 4.7 uM||Antiviral ; Influenza A virus venom, banded krait, Bungarus fasciatus|||Bungarus fasciatus [banded krait]|||Synthetic construct|||Bungarus fasciatus (Banded krait)|||Bungarus fasciatus [banded krait]|||venom, banded krait, Bungarus fasciatus, Asia|||Synthetic construct|||venom, banded krait, Bungarus fasciatus, Asia Helix had little hemolytic activity|||No hemolytic and cytotoxic activity was observed at the dose of up to 400 Âug/ml.|||(PLoS ONE 2008) reported that cathelicidin-BF, isolated from the venom of Bungarus fasciatus, showed no hemolytic activity and did not cause hemoglobin release from human red blood cells even at concentrations as high as 400 µg/ml.|||No hemolytic and cytotoxic activity was observed at the dose of up to 400 Âug/ml.|||Cathelicidin-BF had little hemolytic activity on human red blood cells even with peptide concentrations up to 400000 ug/ml. At the same concentration, cathelicidin-BF was neither cytotoxic for mouse macrophage (RAW264.7) nor for human liver tumor cell (HepG2) (data not shown). Thus, it showed considerable selectivity for microorganisms over mammalian cells in vitro.|||Importantly, it showed low toxicity against human blood cells. PLoS ONE. 2008 Sep 16;3(9):e3217. Pub-Med|||18795096|||29101873|||PLoS One. 2008 Sep 16;3(9):e3217.||Ref.18795096|||18795096|||PLoS ONE. 2008 Sep 16;3(9):e3217. Pub-Med||Tian Y et al. 2013|||https://pubmed.ncbi.nlm.nih.gov/30447229 30 FPDB00352 AP01246|||DRAMP03379|||AP01246|||DRAMP03379 " FLPKTLRKFFCRIRGGRCAVLNCLGKEEQIGRCSNSGRKCCRKKK" Anti-Gram+ & Gram-||Antifungal||candidacidal||Chemotactic||Anticancer||Anti-MRSA||Anti-E faecalis ATCC 51299, activity value is MBC = 1.2||Anti-S. enterica serovar Typhimurium ATCC 13311, activity value is MBC = 0.6||Anti-and yeast C. albicans ATCC 24433, activity value is MBC = 1.2 uM||Antimicrobial||Antibacterial spleen, colon, and tissues of the upper and lower respiratory tract, Mus musculus|||spleen, colon, and tissues of the upper and lower respiratory tract, Mus musculus|||Mus musculus (Mouse)|||spleen, colon, and tissues of the upper and lower respiratory tract, Mus musculus|||Mus musculus (Mouse) Bridge N/A "J Biol Chem. 2008 Feb 29;283(9):5414-9. Pub-Med|||J Biol Chem . 2008 Feb 29;283(9):5414-9. doi: 10.1074/jbc.M709103200. Epub 2007 Dec 31.|||2008 Feb 29;283(9):5414-9. doi: 10.1074/jbc.M709103200. Epub 2007 Dec 31|||Genome Res. 2004 Oct;14(10B):2121-2127.|||J Biol Chem. 2008 Feb 29;283(9):5414-9. Pub-Med|||Genome Res. 2004 Oct;14(10B):2121-2127.J Biol Chem. 2008 Feb 29;283(9):5414-5419." 45 FPDB00367 AP01414|||AP01414|||Brevinin-1BLc|||DRAMP01965|||Brevinin-1BLc|||AP01414 " FLPIIAGIAAKFLPKIFCTISKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 1.5 uM||Anti-C. albicans, activity value is MIC = 3 uM||Antibacterial||Anti-Escherichia coli, activity value is MIC = 25 uM||Anti-Staphylococcus aureus, activity value is MIC = 1.5 uM||Anti-Candida albicans, activity value is MIC = 3 uM North America, leopard frog, Lithobates blairi|||North America, leopard frog, Lithobates blairi|||Rana blairi [Leopard frog]|||Lithobates blairi (plains leopard frog)|||Lithobates blairi (leopard frog)|||Rana blairi [Leopard frog]|||North America, leopard frog, Lithobates blairi|||North America, leopard frog, Lithobates blairi N/A "The document mentions the following hemolysis-related values: brevinin-1BLc: The half-maximal hemolytic concentration (LC₅₀) against human erythrocytes is 9 µM, and the LC₅₀ against HepG2 human hepatocellular carcinoma cells is 6 µM. brevinin-1BLa: The LC₅₀ for human red blood cells is 14 µM, and the LC₅₀ for HepG2 cells is 12 µM. brevinin-1Ya: The LC₅₀ for human red blood cells is 18 µM, and the LC₅₀ for HepG2 cells is 16 µM. brevinin-1Yb: The LC₅₀ for human red blood cells is 16 µM, and the LC₅₀ for HepG2 cells is 11 µM. brevinin-1Yc: The LC₅₀ for human red blood cells is 13 µM, and the LC₅₀ for HepG2 cells is 14 µM. ranatuerin-2Ya: The LC₅₀ for human red blood cells is greater than 100 µM, while the LC₅₀ for HepG2 cells is 20 µM.|||Human erythrocytes ( LC50 = 9 uM ), HepG2 human hepatoma-derived cells ( LC50 = 6 uM )|||In Document 8 (Toxicon 2009), brevinin-1BLa, isolated from the skin secretions of the Plains Leopard Frog (Lithobates blairi), had an LC₅₀ of 14 μM against human red blood cells, and brevinin-1BLc had an LC₅₀ of 9 μM against human red blood cells; brevinin-1Ya, isolated from the skin secretions of the Lowland Leopard Frog (Lithobates yavapaiensis), had an LC₅₀ of 18 μM against human red blood cells, brevinin-1Yb had an LC₅₀ of 16 μM, brevinin-1Yc had an LC₅₀ of 13 μM, and ranatuerin-2Ya had an LC₅₀ greater than 100 μM against human red blood cells.|||[Ref.19254736] LC50=9 uM against human red blood cells. [Ref.14531844]Non-hemolytic activity against human erythrocytes|||Human erythrocytes ( LC50 = 9 uM ), HepG2 human hepatoma-derived cells ( LC50 = 6 uM )" Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. Epub 2009 Feb 28.|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.||Ref.19254736|||19254736||Ref.19254736|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med. 24 FPDB00368 AP01415|||AP01415|||Brevinin-1Ya|||DRAMP01966|||AP01415|||DRAMP01966 " FLPVIAGVAANFLPKLFCAISKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 50 uM||Anti-S. aureus, activity value is MIC = 3 uM||Anti-C. albicans, activity value is MIC = 12 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Escherichia coli, activity value is MIC = 50 uM||Anti-Candida albicans, activity value is MIC = 12 uM||Antimicrobial||Anti-Gram+||Anti-Gram- North America, leopard frog, Lithobates yavapaiensis|||North America, leopard frog, Lithobates yavapaiensis|||Rana blairi [Leopard frog]|||Lithobates yavapaiensis (North America leopard frog)|||North America, leopard frog, Lithobates yavapaiensis|||Lithobates blairi (leopard frog) N/A "The document mentions the following hemolysis-related values: brevinin-1BLc: The half-maximal hemolytic concentration (LC₅₀) against human erythrocytes is 9 µM, and the LC₅₀ against HepG2 human hepatocellular carcinoma cells is 6 µM. brevinin-1BLa: The LC₅₀ for human red blood cells is 14 µM, and the LC₅₀ for HepG2 cells is 12 µM. brevinin-1Ya: The LC₅₀ for human red blood cells is 18 µM, and the LC₅₀ for HepG2 cells is 16 µM. brevinin-1Yb: The LC₅₀ for human red blood cells is 16 µM, and the LC₅₀ for HepG2 cells is 11 µM. brevinin-1Yc: The LC₅₀ for human red blood cells is 13 µM, and the LC₅₀ for HepG2 cells is 14 µM. ranatuerin-2Ya: The LC₅₀ for human red blood cells is greater than 100 µM, while the LC₅₀ for HepG2 cells is 20 µM.|||HepG2 cells ( LC50 = 20 uM ), Human erythrocytes ( LC50 > 100 uM )|||highly hemolytic HC50 18 uM, hemolytic. Updated 7/2020; 7/2021" Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. Epub 2009 Feb 28.|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.||Ref.19254736|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||Toxicon. 2009 Jun;53(7-8):699-705.|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med. 24 FPDB00369 AP01416|||AP01416|||AP01417|||Brevinin-1Yb|||DRAMP01967|||AP01416|||DRAMP01967 " FLPIIAGAAAKVVQKIFCAISKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 3 uM||Anti-C. albicans, activity value is MIC = 3 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Escherichia coli, activity value is MIC = 25 uM||Anti-Candida albicans, activity value is MIC = 3 uM||Antimicrobial||Anti-Gram+||Anti-Gram- North America, leopard frog, Lithobates yavapaiensis|||North America, leopard frog, Lithobates yavapaiensis|||Rana blairi [Leopard frog]|||Lithobates yavapaiensis (North America leopard frog)|||North America, leopard frog, Lithobates yavapaiensis|||Lithobates yavapaiensis (North America leopard frog) N/A "The document mentions the following hemolysis-related values: brevinin-1BLc: The half-maximal hemolytic concentration (LC₅₀) against human erythrocytes is 9 µM, and the LC₅₀ against HepG2 human hepatocellular carcinoma cells is 6 µM. brevinin-1BLa: The LC₅₀ for human red blood cells is 14 µM, and the LC₅₀ for HepG2 cells is 12 µM. brevinin-1Ya: The LC₅₀ for human red blood cells is 18 µM, and the LC₅₀ for HepG2 cells is 16 µM. brevinin-1Yb: The LC₅₀ for human red blood cells is 16 µM, and the LC₅₀ for HepG2 cells is 11 µM. brevinin-1Yc: The LC₅₀ for human red blood cells is 13 µM, and the LC₅₀ for HepG2 cells is 14 µM. ranatuerin-2Ya: The LC₅₀ for human red blood cells is greater than 100 µM, while the LC₅₀ for HepG2 cells is 20 µM." Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med|||2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. Epub 2009 Feb 28.|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.||Ref.19254736|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med. 24 FPDB00370 AP01417|||Brevinin-1Yc|||DRAMP01968|||AP01417 " FLPIIAGAAAKVVEKIFCAISKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Escherichia coli, activity value is MIC = 100 uM||Anti-Candida albicans, activity value is MIC = 6 uM||Anti-E. coli, activity value is MIC = 100 uM North America, leopard frog, Lithobates yavapaiensis|||Rana blairi [Leopard frog]|||Lithobates yavapaiensis (North American leopard frog)|||North America, leopard frog, Lithobates yavapaiensis N/A In Document 8 (Toxicon 2009), brevinin-1BLa, isolated from the skin secretions of the Plains Leopard Frog (Lithobates blairi), had an LC₅₀ of 14 μM against human red blood cells, and brevinin-1BLc had an LC₅₀ of 9 μM against human red blood cells; brevinin-1Ya, isolated from the skin secretions of the Lowland Leopard Frog (Lithobates yavapaiensis), had an LC₅₀ of 18 μM against human red blood cells, brevinin-1Yb had an LC₅₀ of 16 μM, brevinin-1Yc had an LC₅₀ of 13 μM, and ranatuerin-2Ya had an LC₅₀ greater than 100 μM against human red blood cells.|||[Ref.19254736] LC50=13 uM against human red blood cells Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med.|||19254736|||Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.||Ref.19254736|||19254736||Ref.19254736|||Toxicon. 2009 Jun;53(7-8):699-705. Pub-Med. 24 FPDB00375 AP01467|||3495|||3501|||3502|||3519|||3520|||3526|||3527|||3544|||3545|||3551|||3552|||3569|||AP01467|||LL-III|||LL-III/5|||LL-III/6|||Lasioglossin LL-III|||LL-III|||AP01467|||DRAMP02991|||DRAMP18608|||DRAMP18609 " VNWKKILGKIIKVVK" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||activity value is IC50 = 4||activity value is IC50 = 12||activity value is IC50 = 3||activity value is IC50 = 5||activity value is IC50 = 18||activity value is IC50 = 25||activity value is IC50 = 13 uM||activity value is IC50 = 9 uM||Anti-B. subtilis, activity value is MIC = 0.7 uM||Anti-S. aureus, activity value is MIC = 3.9 uM||Anti-P. aeruginosa, activity value is MIC = 18.7 uM||Anti-and E. coli, activity value is MIC = 1.4 uM||Anti-B. subtilis, activity value is MIC = 0.8 uM||Anti-S. aureus, activity value is MIC = 14.3 uM||Anti-P. aeruginosa, activity value is MIC = 15.8 uM||Anti-and E. coli, activity value is MIC = 1.7 uM||Anti-Bacillus subtilis, activity value is MIC = 0.7 uM||Anti-Staphylococcus aureus, activity value is MIC = 3.9 uM||Anti-Escherichia coli, activity value is MIC = 1.4 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 18.7 uM||Anti-Bacillus subtilis, activity value is MIC = 1.2 uM||Anti-Staphylococcus aureus, activity value is MIC = 40 uM||Anti-Escherichia coli, activity value is MIC = 3.5 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 40 uM||Anti-Bacillus subtilis, activity value is MIC = 0.5 uM||Anti-Staphylococcus aureus, activity value is MIC = 2.1 uM||Anti-Escherichia coli, activity value is MIC = 1 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 22.5 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 3.5 uM||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 1 uM the Eusocial Bee Lasioglossum laticeps|||Synthetic construct|||Lasioglossum laticeps [Wild eusocial bee]|||Lasioglossum laticeps [Broad-faced furrow bee]|||venom, the Eusocial Bee Lasioglossum laticeps, Europe|||Lasioglossum laticeps (Eusocial Bee)|||Synthetic construct|||venom, the Eusocial Bee Lasioglossum laticeps, Europe Helix "LC50>220 uM|||The document mentions the following hemolysis-related values: LL-I, LL-II, LL-III: at concentrations up to 200 μM, the hemolysis rate on red blood cells is 0% (no hemolytic activity). LL-II/3, LL-III/3: after replacing Gly8 with Lys, hemolytic activity slightly increases, but the specific values are not clearly stated. LL-III/5 (C-terminal deamidation): no hemolytic activity. LL-III/6 (C-terminal esterification): hemolytic activity increases, but no specific HC₅₀ value is given.|||Rat red blood cells (LC50 = >200 uM)|||Rat red blood cells (LC50 = 79.3 uM)|||human erythrocytes (LD50 = 157 uM)|||[Ref.19591185]LC50>200 uM against rat red blood cells|||[Ref.19591185]LC50=79.3 uM against rat red blood cells" Chembiochem. 2009 Aug 17;10(12):2089-99. PubMed.|||2009 Aug 17;10(12):2089-99. doi: 10.1002/cbic.200900133.||Vrablikova et al., 2017|||19591185|||19591185, 28892177|||30753486|||Chembiochem. 2009 Aug 17;10(12):2089-99. PubMed.||Vrablikova et al., 2017|||Chembiochem. 2009 Aug 17;10(12):2089-2099.|||Chembiochem. 2009 Aug 17;10(12):2089-2114.||Ref.19591185|||Chembiochem. 2009 Aug 17;10(12):2089-2115.||Ref.19591185 15 L FPDB00376 AP01478 PMPVSQECFETLRGHERILSILRHQNLLKELQDLALQGAKERAHQQ Antifungal||candidacidal||Anticancer||Anti-and C. tropicalis at a concentration, activity value is MIC < 0.5 uM Homo sapiens Helix N/A Interdiscip Sci. 2015 Feb 14. in press. Li RF et al., 2015|||Interdiscip Sci. 2015 Feb 14. in press. Li RF et al., 2015||Li RF et al., 2015|||Interdiscip Sci. 2015 Feb 14. in press. Li RF et al., 2015 46 FPDB00383 AP01650|||AP01650|||Crotamine|||DRAMP02511|||AP01650|||DRAMP02511 " YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSG" Anti-Gram+ & Gram-||Antifungal||Antiparasitic||Channel inhibitors||Antimalarial||Hemolytic||Anticancer||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-||Cytotoxic||It's now found to have multiple functions||including cell-penetrating (targeting lysosomes) and antimicrobial activities . Active against P. falciparum. Crotamine preferentially targets eukaryotic cells over prokaryotic Kv channels. venom, Crotalus durissus terrificus|||venom, Crotalus durissus terrificus|||Crotalus durissus terrificus [South American rattlesnake]|||Crotalus durissus terrificus (South American rattlesnake)|||venom, Crotalus durissus terrificus, South America|||Crotalus durissus terrificus (South American rattlesnake)|||venom, Crotalus durissus terrificus, South America Combine Helix and Beta structure||Combine helix and strand structure N/A "Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-7. PubMed.|||Proc Natl Acad Sci U S A . 2009 Sep 1;106(35):14972-7. doi: 10.1073/pnas.0904465106. Epub 2009 Aug 13.|||19706485|||Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-14977.|||Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-7. PubMed.||see ref|||Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-14977. Toxicon. 2005 Dec 1;46(7):759-767. Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):213-215. Toxicon. 1998 Dec;36(12):1927-1937. Mol Pharm. 2012 Feb 6|||Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-7. PubMed." 42 FPDB00400 AP01922|||3647|||3675|||3690|||3703|||AP01922|||CAMPSQ3627|||DRAMP20779 " GMWSKILGHLIR" Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||activity value is IC50 > 100 uM||activity value is IC50 = 49||Anti-E. coli, activity value is MIC = 0.8||Anti-and CCRF-CEMT, activity value is IC50 = 11||Antibacterial||Anti-Escherichia coli, activity value is MIC = 3.8 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 45 uM||Anti-## Gram-positive bacteria: Bacillus subtilis, activity value is MIC = 0.8 uM||Anti-Staphylococcus aureus, activity value is MIC = 7.7 uM venom, the eusocial bee, Halictus sexcinctus|||Synthetic construct|||Halictus sexcinctus|||venom, the eusocial bee, Halictus sexcinctus, Europe, Asia|||Halictus sexcinctus Helix Hemolytic activity LC50=82 uM|||venom, the eusocial bee, Halictus sexcinctus||82 µM (for rat red blood cells) (LC50, µM) Note: The hemolytic activity for human red blood cells is 102 µM.|||[Ref.20198492] LC50=82 uM against rat red blood cells "Amino Acids. 2010 Aug;39(3):763-75. PubMed.|||Amino Acids. 2010 Aug;39(3):763-75. doi: 10.1007/s00726-010-0519-1. Epub 2010 Mar 3.||Slaninova J et al. 2012 Peptides 33:18-26|||20198492|||Amino Acids . 2010 Aug;39(3):763-75. doi: 10.1007/s00726-010-0519-1. Epub 2010 Mar 3.||Slaninova J et al. 2012 Peptides 33:18-26|||Amino Acids. 2010 Aug;39(3):763-75.||Ref.20198492|||Amino Acids. 2010 Aug;39(3):763-75. PubMed." 12 L FPDB00401 AP01923|||3649|||3654|||3677|||3682|||3705|||3710|||AP01923|||CAMPSQ3628|||HAL-2|||AP01923|||DRAMP20780 " GKWMSLLKHILK" Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anticancer||activity value is IC50 = 12||activity value is IC50 = 15||activity value is IC50 = 35||activity value is IC50 > 40 uM||activity value is IC50 = 34 uM||Anti-E. coli, activity value is MIC = 0.8||Anti-and CCRF-CEMT, activity value is IC50 = 12||Antibacterial||Anti-Escherichia coli, activity value is MIC = 2.5 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 42.1||Anti-## Gram-positive bacteria: Bacillus subtilis, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 8.1 uM venom, the eusocial bee, Halictus sexcinctus|||Halictus sexcinctus|||Synthetic construct|||Synthetic construct|||Halictus sexcinctus [six-banded furrow bee]|||venom, the eusocial bee, Halictus sexcinctus, Europe, Asia|||Halictus sexcinctus|||venom, the eusocial bee, Halictus sexcinctus, Europe, Asia Helix Hemolytic activity LC50=78.1 uM|||venom, the eusocial bee, Halictus sexcinctus||78.1 µM (for rat red blood cells) (LC50, µM) Note: The hemolytic activity for human red blood cells is 91 µM.|||human erythrocytes (LD50 = 78 uM)|||[Ref.20198492] LC50=78.1 uM against rat red blood cells "Amino Acids. 2010 Aug;39(3):763-75. PubMed.|||Amino Acids. 2010 Aug;39(3):763-75. doi: 10.1007/s00726-010-0519-1. Epub 2010 Mar 3.||Slaninova J et al. 2012 Peptides 33:18-26|||20198492|||28600071|||30753486|||Amino Acids . 2010 Aug;39(3):763-75. doi: 10.1007/s00726-010-0519-1. Epub 2010 Mar 3.||Slaninova J et al. 2012 Peptides 33:18-26|||Amino Acids. 2010 Aug;39(3):763-75.||Ref.20198492|||Amino Acids. 2010 Aug;39(3):763-75. PubMed." 12 L FPDB00402 AP01956|||3586|||3591|||3592|||3595|||3596|||3602|||3607|||3608|||3611|||3612|||3618|||3623|||3624|||3627|||3628|||DRAMP20935|||AP01956|||DRAMP20935 " GFGMALKLLKKVL" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||activity value is IC50 = 10||activity value is IC50 = 15||activity value is IC50 = 8||activity value is IC50 = 32||activity value is IC50 = 21||activity value is IC50 = 23||activity value is IC50 = 49||activity value is IC50 = 29||activity value is IC50 > 100 uM||activity value is IC50 = 68||activity value is IC50 = 12||activity value is IC50 = 29 uM||activity value is IC50 = 15 uM||activity value is IC50 = 70 uM||activity value is IC50 = 43||Anti-B. subtilis, activity value is MIC = 1.3 uM||Anti-S. aureus, activity value is MIC = 3.7 uM||Anti-L. monocytogenes KCTC 3710, activity value is MIC = 25 uM||Anti-E. coli, activity value is MIC = 3 uM||Anti-P. aeruginosa, activity value is MIC = 6.25||Anti-E. coli, activity value is MIC = 6.25 uM||Anti-and C. albicans, activity value is MIC = 6.3 uM||Anti-Escherichia coli, activity value is MIC = 3 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 35 uM||Anti-Bacillus subtilis, activity value is MIC = 1.3 uM||Anti-Staphylococcus aureus, activity value is MIC = 3.7 uM||Anti-Fungus: Candida albicans, activity value is MIC = 6.3 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 3.13 uM||Anti-Listeria monocytogenes KCTC 3710, activity value is MIC = 25 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 6.25 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.25 uM||Anti-## Gram-positive bacteria: Bacillus subtilis, activity value is MIC = 1.3 uM||Anti-## Fungus: Candida albicans, activity value is MIC = 6.3 uM||Anti-##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 6.25 uM venom, the solitary bee Macropis fulvipes|||Macropis fulvipes (Solitary bee) (Megilla fulvipes)|||venom, the solitary bee Macropis fulvipes, Europe|||Macropis fulvipes (Solitary bee) (Megilla fulvipes)|||venom, the solitary bee Macropis fulvipes, Europe Helix||Alpha helix,random coil "Hemolysis LC50=165 uM|||venom, the solitary bee Macropis fulvipes|||- Test conditions: 4% human red blood cell suspension, incubated at 37°C for 1 hour, detection wavelength 540 nm; blank control (physiological solution only) represents 0% hemolysis, 0.2% Triton X-100 represents 100% hemolysis. - Natural peptide MAC-1 (macropin): LC_{50} = 160 μM, showing moderate hemolytic activity. - All-D type analog MAC-1/1: LC_{50} = 152.0 μM, hemolytic activity close to that of the natural peptide. - Low hemolytic analogs (LC_{50} > 200 μM): MAC-1/7, MAC-1/8, MAC-1/14, MAC-1/15, MAC-1/16, MAC-1/17, MAC-1/13, MAC-1/18, MAC-1/4, MAC-1/19, among which MAC-1/31 has LC_{50} > 800 μM, with extremely low hemolytic activity. - High hemolytic analogs: MAC-1/3 (LC_{50} = 53.0 μM), MAC-1/24 (LC_{50} = 88 μM), MAC-1/25 (LC_{50} = 88 μM), MAC-1/26 (LC_{50} = 93 μM), with hemolytic activity significantly higher than that of the natural peptide. - Other key analogs: MAC-1/2 (LC_{50} = 241 μM), MAC-1/9 (LC_{50} = 199 μM), MAC-1/10 (LC_{50} = 476 μM), MAC-1/20 (LC_{50} = 262 μM), MAC-1/27 (LC_{50} = 391 μM), MAC-1/28 (LC_{50} = 120 μM), MAC-1/29 (LC_{50} = 131 μM), MAC-1/30 (LC_{50} = 345 μM).|||The hemolytic activity of hainanenin-1 and 5 was then tested. But undesirably, the result showed that hainanenin-1 and 5 possessed strong hemolytic activity on human erythrocytes. At con- centrations of 25 ␮g/ml and 50 ␮g/ml (5–10 times of MICs), the hemolytic rate of hainanenin-1 was 20.72% and 42.34%, respec- tively. At the same concentrations, hainanenin-5 exhibited higher hemolytic rate of 23.31% and 49.16%, respectively.|||[Ref.24616110] LC50=160 uM against human red blood cells. ##[Ref.29185466]5% hemolysis at 25 uM against red blood cells, 93% hemolysis at 50 uM against red blood cells|||HC50 160 uM." "Peptides. 2012 Jan;33(1):18-26. PubMed.|||Peptides. 2012 Jan;33(1):18-26. doi: 10.1016/j.peptides.2011.11.002. Epub 2011 Nov 7.|||Sci Rep. 2017 Nov 29;7(1):16580. doi: 10.1038/s41598-017-16784-6.||Ref.24616110||Ref.29185466|||Peptides . 2012 Jan;33(1):18-26. doi: 10.1016/j.peptides.2011.11.002. Epub 2011 Nov 7.|||J Pept Sci. 2014 Jun;20(6):375-84. doi: 10.1002/psc.2625. Epub 2014 Mar 11.## Sci Rep. 2017 Nov 29;7(1):16580. doi: 10.1038/s41598-017-16784-6.||Ref.24616110||Ref.29185466|||Peptides. 2012 Jan;33(1):18-26. PubMed." 13 L FPDB00403 AP01957|||3587|||3619|||DRAMP31770 GTGLPMSERRKIMLMMR Anti-Gram+ & Gram-||Antifungal||Anticancer||activity value is IC50 > 100 uM||activity value is IC50 = 32 uM||Antimicrobial venom, the solitary bee Macropis fulvipes|||venom, the solitary bee Macropis fulvipes, Europe|||Synthetic N/A "Hemolysis LC50>200 uM|||venom, the solitary bee Macropis fulvipes|||The hemolytic activity of hainanenin-1 and 5 was then tested. But undesirably, the result showed that hainanenin-1 and 5 possessed strong hemolytic activity on human erythrocytes. At con- centrations of 25 ␮g/ml and 50 ␮g/ml (5–10 times of MICs), the hemolytic rate of hainanenin-1 was 20.72% and 42.34%, respec- tively. At the same concentrations, hainanenin-5 exhibited higher hemolytic rate of 23.31% and 49.17%, respectively.|||Human erythrocytes: IC50>200 uM" "Peptides. 2012 Jan;33(1):18-26. PubMed.|||Peptides. 2012 Jan;33(1):18-26. doi: 10.1016/j.peptides.2011.11.002. Epub 2011 Nov 7.|||Peptides . 2012 Jan;33(1):18-26. doi: 10.1016/j.peptides.2011.11.002. Epub 2011 Nov 7.|||Peptides. 2012 Jan;33(1):18-26.|||Peptides. 2012 Jan;33(1):18-26. PubMed." 17 L FPDB00404 AP01964|||AP01964|||Hymenochirin-1B|||Hymenochirin-1B|||AP01964|||DRAMP04654 " IKLSPETKDNLKKVLKGAIKGAIAVAKMV" Anti-Gram+ & Gram-||Antifungal||anti-diabetes||Anticancer||Anti-K. pneumoniae, activity value is MIC = 20||Escherichia coli||Pseudomonas aeruginosa||Klebsiella pneumoniae||Staphylococcus aureus||Candida albicans||Anti-L. rhamnosus LGG, activity value is MIC = 250 ug/ml||Anti-L. casei R0215, activity value is MIC = 250 ug/ml||Anti-L. casei Shirota, activity value is MIC = 32 ug/ml||Anti-S. suis S10, activity value is MIC = 32 ug/ml||Antibacterial||Anti-Cancer cell lines: A549, activity value is IC50 = 15.22||Anti-HCT116, activity value is IC50 = 12.76||Anti-HepG2, activity value is IC50 = 8.07||Anti-S. aureus ATCC 29213, activity value is MIC = 12.5 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-S.epidermidis RP62A, activity value is MIC = 3.1 uM||Anti-S.epidermidis RP62A/1, activity value is MIC = 1.6 uM||Anti-C.albicans ATCC 90028, activity value is MIC = 100 uM||Anti-##Gram-negative bacteria: E.coli, activity value is MIC = 25 uM||Anti-A. baumannii, activity value is MIC = 6.25 uM||Anti-S. maltophilia, activity value is MIC = 6.25 uM||Anti-K. pneumoniae, activity value is MIC = 25 uM||Anti-P. aeruginosa, activity value is MIC = 50 uM||Anti-P.mirabilis, activity value is MIC > 100 uM Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa|||Hymenochirus boettgeri [Congo dwarf clawed frog]|||Hymenochirus boettgeri|||Hymenochirus boettgeri [Congo dwarf clawed frog]|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa|||Hymenochirus boettgeri (Congo dwarf clawed frog)|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa α-helical (most likely) "LC50=225 uM|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa||LC₅₀ = 225 µM (for human red blood cells)|||The abilities of the synthetic hymenochirins to inhibit the growth of reference strains of the Gram-positive bacterium S. aureus, the Gram-negative bacteria E. coli, K. pneumoniae, and P. aeruginosa, and the opportunistic yeast pathogen C. albicans are compared in Table 1. The MIC values for hymenochirin-5B may be artefactually high because of the restricted solubility of the peptide in Mueller-Hinton broth and its tendency to form a gel in con- centrated solution. All peptides displayed relatively low hemolytic activities against human erythrocytes (LC50 in the range 160 to >300 ␮M).|||[Ref.30789695] It has 5%, 6.3%, 7.7%, 10%, 10.7%, 15.3%, 9%, 15% and 9.7% hemolysis against fresh rabbit blood cells at 0.010, 0.25, 0.5, 1.0, 2.0, 5.0, 10.0, 20.0, 25 uM|||[Ref.24172540] LC₅₀ = 213 ± 18 uM against freshly prepared human erythrocytes." "Peptides. 2012 Jun;35(2):269-75. PubMed.|||Peptides. 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 3.||Owolabi BO et al., 2016||Zhang et al., 2019|||22497805|||31102497|||22497805|||Peptides . 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 3.||Owolabi BO et al., 2016||Zhang et al., 2019|||ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.||Ref.30789695|||Ref.24172540|||Peptides. 2012 Jun;35(2):269-75. PubMed." 29 FPDB00416 AP02111|||DRAMP01447|||AP02111|||DRAMP01447 " GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-diabetes||Anticancer||Anti-Bacteria E. coli, activity value is MIC = 5 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 5 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 5 uM||Anti-S. aureus, activity value is MIC = 5 uM||Anti-A. baumannii, activity value is MIC = 5 uM||Anti-and S. maltophilia, activity value is MIC < 10 uM||Anti-E. coli, activity value is MIC = 5 uM||Anti-K. pneumoniae, activity value is MIC = 5 uM||Anti-P. aeruginosa, activity value is MIC = 5 uM skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America|||skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America|||Lithobates chiricahuensis|||skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America|||Lithobates chiricahuensis N/A skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America||At a concentration of 100 μM, the hemolysis rate is < 10%.|||[Ref.21262304] LC50=150 uM against human erythrocytes|||less hemo.lytic (hRBC HC50=150 uM) "Peptides. 2011 Apr;32(4):664-9. Pub-Med.|||Peptides . 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.|||Peptides. 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.||Ojo et al., 2015|||Peptides. 2011 Apr;32(4):664-669.|||21262304|||Peptides . 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.||Ojo et al., 2015|||Gram-negative bacteria: E. coli (MIC=5 uM), K. pneumoniae (MIC=5 uM), P. aeruginosa (MIC=5 uM); Gram-positive bacterium: S. aureus (MIC=5 uM). Yeast: C. albicans (MIC=10 uM).|||Peptides. 2011 Apr;32(4):664-9. Pub-Med." 37 FPDB00418 AP02135|||AP02135|||TP4|||DRAMP018494|||TP4|||AP02135 " FIHHIIGGLFSAGKAIHRLIRRRRR" Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis||Hemolytic||Wound healing||Anticancer||Anti-Gram-negative V. vulnificus 204, activity value is MIC = 0.03 ug/ml||Anti-A. hydrophila BCRC 13018, activity value is MIC = 1.05 ug/ml||Anti-V. alginolyticus, activity value is MIC = 0.03 ug/ml||Anti-P. aeruginosa ATCC 19660, activity value is MIC = 0.52 ug/ml||Anti-S. agalactiae 819, activity value is MIC = 2.1 ug/ml||Anti-E. faecalis BCRC 10066, activity value is MIC = 8.39 ug/ml||Anti-which is active against S. aureus, activity value is MIC = 5 uM||Anti-B. subtilis, activity value is MIC = 1.7 uM||Anti-E. tarda, activity value is MIC = 20 uM||Anti-Vibrio vulnificus 204, activity value is MIC = 0.03 ug/ml||Anti-Aeromonas hydrophila BCRC 13018, activity value is MIC = 1.05 ug/ml||Anti-Vibrio alginolyticus, activity value is MIC = 0.03 ug/ml||Anti-Pseudomonas aeruginosa ATCC 19660, activity value is MIC = 0.52 ug/ml||Anti-Streptococcus agalactiae 819, activity value is MIC = 2.1 ug/ml||Anti-S. agalactiae BCRC 10787, activity value is MIC = 0.13 ug/ml||Anti-P. aeruginosa, activity value is MIC = 64 ug/ml||Anti-S. aureus, activity value is MIC = 8 ug/ml||Anti-MRSA, activity value is MIC = 16 ug/ml||Anti-C. albicans, activity value is MIC = 128 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||activity value is MBC = 16 ug/ml||Anti-Methicillin-resistant Staphylococcus aureus, activity value is MIC = 16 ug/ml||activity value is MBC = 32 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 64 ug/ml||activity value is MBC = 128 ug/ml||Anti-Candida albicans, activity value is MIC = 128 ug/ml gills, Nile Tilapia, Oreochromis niloticus|||gills, Nile Tilapia, Oreochromis niloticus|||Oreochromis niloticus [Nile tilapia]|||Oreochromis niloticus|||Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)|||Oreochromis niloticus|||gills, Nile Tilapia, Oreochromis niloticus Helix||Alpha helix "were hemolytic in fish red blood cells at 100000 ug/ml for 100% hemolysis|||TP1 and TP5 showed no hemolytic activity at a concentration of 100 µg/ml. TP2 had a hemolysis rate of 60% at a concentration of 40 µg/ml. TP3 had a hemolysis rate of 42% at a concentration of 100 µg/ml. TP4 had a hemolysis rate of 100% at a concentration of 100 µg/ml.|||gills, Nile Tilapia, Oreochromis niloticus||HC₅₀ = 5 uM。|||Mouse erythrocytes (100% hemolysis, 25 ug/ml)|||Mouse erythrocytes (100% hemolysis, 25 ug/ml)|||. TP4 presented excellent antimicrobial activity compared to cod pis 1 and grouper epinecidin-1. Furthermore, the TP1,5 synthetic peptides were assayed for hemolytic activities in fish blood cells. The TP1 and TP5 synthetic peptides showed no hemolytic activity, and even when treated with 100000 ug/ml peptide, no hemolytic activity was detected (Fig. 5). In contrast, TP4 and TP3 were hemolytic in fish red blood cells at 100000 ug/ml for 100% hemolysis and 42% hemolysis, respectively (Fig. 5). TP2 achieved 60% hemolysis at 40000 ug/ml.|||fish RBCs, HC50 50 ug/ml, moderate hemolytic." "PLoS One. 2012;7(11):e50263. Pub-Med.|||2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30.||Kuo et al., 2018||Ting CH et al., 2016|||PLoS One. 2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30.||Kuo et al., 2018||Ting CH et al., 2016|||23226256|||29040295|||PLoS One. 2017 Oct 17;12(10):e0186442.||Ref.29040295|||29040295|||PLoS One . 2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30||Kuo et al., 2018||Ting CH et al., 2016|||PLoS One. 2012;7(11):e50263. Pub-Med." 25 FPDB00421 AP02141|||1670|||1674|||1678|||1682|||1686|||1690|||1694|||1698|||1702|||DRAMP31797 " LLRHVVKILEKYL" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anticancer||57.62 Inhibition ratio at 50 ug/ml||52.77 Inhibition ratio at 50 ug/ml||52.32 Inhibition ratio at 50 ug/ml||50.90 Inhibition ratio at 50 ug/ml||48.19 Inhibition ratio at 50 ug/ml||45.62 Inhibition ratio at 50 ug/ml||37.22 Inhibition ratio at 50 ug/ml||30.82 Inhibition ratio at 50 ug/ml||24.15Inhibition ratio at 50 ug/ml||predicted to be helical.||Anti-S. aureus ATCC 25923, activity value is MIC = 2.5 ug/ml||Anti-S. suis 2 CVCC 606, activity value is MIC = 15.6 ug/ml||Anti-C. albicans ATCC10231, activity value is MIC = 31.25 ug/ml||Anti-Salmonella ATCC 20020, activity value is MIC = 15.6 ug/ml||Anti-P. aeruginosa ATCC 227853, activity value is MIC = 60 ug/ml||Anti-B-subtitlis, activity value is MIC > 64 uM||Anti-M. luteus, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 8 uM||Anti-P. vulgaris, activity value is MIC = 16 uM||Antimicrobial Skin,The American bullfrog, Lithobates Catesbeianus, North America|||Skin,The American bullfrog, Lithobates Catesbeianus, North America|||Temporins family N/A showed no measurable hemolytic activity against rabbit erythrocytes at 250 ug/ml|||Skin,The American bullfrog, Lithobates Catesbeianus, North America||At a concentration of 50 µM, the hemolysis rate exceeds 50%.|||Showed no hemolytic activity against rabbit erythrocytes and human erythrocytes at 250 ug/ml Molecular Cloning – Selected Applications in Medicine and Biology 2011 Sci Direct.|||Molecular Cloning – Selected Applications in Medicine and Biology 2011|||Molecular Cloning – Selected Applications in Medicine and Biology 2011 Sci Direct.|||J Pept Sci. 2012 Jul;18(7):476-86. 13 L FPDB00425 AP02228 " RKGWFKAMKSIAKFIAKEKLKEHL" Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anticancer||Anti-Gram-Negative Bacteria E. coli CGMCC1.1369, activity value is MIC = 25 uM||Anti-E. cloacae CGMCC1.58, activity value is MIC = 50 uM||Anti-Positive E. faecalis CGMCC1.100, activity value is MIC = 25 uM||Anti-B. thuringiensis Israel H14, activity value is MIC = 12.5 uM||Anti-B. cereus CMCC1.126, activity value is MIC = 6.2 uM||Anti-T. halophilus CGMCC1.2492, activity value is MIC = 3.1 uM||Anti-A. flavus CGMCC3.6433, activity value is MIC = 3.1 uM||Anti-B. bassiana CGMCC3.3576, activity value is MIC = 6.2 uM||Anti-and S. cerevisiae CGMCC2.1619, activity value is MIC = 50 uM Venom, Lycosa singoriensis|||Venom, Lycosa singoriensis, Europe Helix Venom, Lycosa singoriensis|||10% hemolysis at 100 uM "Curr Mol Med. 2012 Dec;12(10):1350-60. Pub-Med.|||Curr Mol Med. 2012 Dec;12(10):1350-60. Pub-Med.||Tang et al., 2019|||Curr Mol Med . 2012 Dec;12(10):1350-60. doi: 10.2174/156652412803833643.||Tang et al., 2019|||Curr Mol Med. 2012 Dec;12(10):1350-60. Pub-Med." 24 FPDB00426 AP02234|||3130|||3131|||3132|||3133|||3134|||DRAMP21244|||AP02234|||DRAMP21244 " FLSLIPKLVKKIIKAFK" Anti-Gram+ & Gram-||Antifungal||Hemolytic||Anticancer||activity value is IC50 = 1.5 uM||activity value is IC50 = 1.6 uM||activity value is IC50 = 1.8 uM||activity value is IC50 = 2.1 uM||activity value is IC50 = 2.9 uM||Anti-Staphylococcus aureus, activity value is MIC = 2.5 uM||Anti-Escherichia coli, activity value is MIC = 5 uM||Anti-Candida albicans, activity value is MIC = 2.5 uM||activity value is MBC = 20 uM||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 5 uM||Anti-##Fungi : Candida albicans, activity value is MIC = 2.5 uM||activity value is MBC = 5 uM The inactive natural peptide TsAP-1 was made active by increasing 4 lysines and one leucine, template-based design|||Synthetic construct|||The inactive natural peptide TsAP-1 was made active by increasing 4 lysines and one leucine, template-based design|||Synthetic construct Alpha helix "The inactive natural peptide TsAP-1 was made active by increasing 4 lysines and one leucine, template-based design||The hemolysis rate is 28% at 5 uM; concentrations of 20 uM and above cause complete hemolysis.|||- TsAP-1: At 160 µM, the hemolysis rate is only 6.48%, indicating low hemolytic activity. - TsAP-2: No hemolysis at ≤15 µM; 86% hemolysis at 40 µM; complete hemolysis (100%) at ≥80 µM. - TsAP-S1: 28% hemolysis at 5 µM; complete hemolysis (100%) at ≥20 µM. - TsAP-S2: 28% hemolysis at 5 µM; complete hemolysis (100%) at ≥20 µM.|||[Ref.23770440] 30% hemolysis at 5 uM , 85% hemolysis at 10 uM , 100% hemolysis at 20 uM against horse red blood cells|||not hemolytic at 15 uM, but it caused 50% hemolysis (HC50 at ~30 uM and 100% hemolysis at 80 uM (Hemolytic)." "Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. Pub-Med.|||Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. Pub-Med.|||Biochimie. 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003.||Ref.23770440|||Biochimie . 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003. Epub 2013 Jun 14.|||Biochimie. 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003.||Ref.23770440" 17 L FPDB00427 AP02235|||3125|||3126|||3127|||3128|||3129|||AP02235|||Putative antimicrobial peptide clone 4|||Antimicrobial peptide TsAP-2|||NDBP-4.23|||DRAMP03688|||Antimicrobial peptide TsAP-2|||NDBP-4.23|||AP02235 " FLGMIPGLIGGLISAFK" Anti-Gram+||Antifungal||candidacidal||Hemolytic||Antibiofilm||Anticancer||activity value is IC50 = 4.1 uM||activity value is IC50 = 11 uM||activity value is IC50 = 6.4 uM||activity value is IC50 = 13.3 uM||activity value is IC50 = 15.4 uM||Anti-S. aureus, activity value is MIC = 5 uM||activity value is MBC = 10 uM||Anti-E.coli, activity value is MIC > 320 uM||Anti-C. tropicalis ATCC 750, activity value is MIC = 6.25 uM||Anti-C. parapsilosis ATCC22019, activity value is MIC = 100 uM||Anti-C. neoformans H99 serotype A, activity value is MIC = 25 uM||Anti-and C. neoformans B3501 serotype D, activity value is MIC = 12.5 uM||Anti-S.aureus, activity value is MIC = 5 uM||Anti-C.albicans, activity value is MIC = 10 uM||Anti-C. albicans SC5314, activity value is MIC = 50 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 100 uM||Anti-C. glabrata ATCC 90030, activity value is MIC > 400 uM||Anti-C. neoformans B3501 serotype D, activity value is MIC = 12.5 uM||Wound healing||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 15.6 ug/ml||Anti-B. cereus ATCC 11778, activity value is MIC = 31.2 ug/ml||Anti-K.pneumoniae ATCC 23357, activity value is MIC = 250 ug/ml||Anti-S.Typhimurium ATCC14028, activity value is MIC > 250 ug/ml||Anti-C.freundii ATCC 8090, activity value is MIC > 250 ug/ml||Anti-and E.coli EPEC CDC O86:H35, activity value is MIC = 125 ug/ml venom, the Brazilian yellow scorpion, Tityus serrulatus, also Turrilites costatus; Tityus obscurus, South America|||Tityus costatus|||T. costatus|||venom, the Brazilian yellow scorpion, Tityus serrulatus, also Turrilites costatus; Tityus obscurus, South America|||Vespa magnifica|||venom, the Brazilian yellow scorpion, Tityus serrulatus, also Turrilites costatus; Tityus obscurus, South America Helix "venom, the Brazilian yellow scorpion, Tityus serrulatus, also Turrilites costatus; Tityus obscurus, South America||No obvious hemolysis is observed at low concentrations (≤15 uM); the hemolysis rate reaches 86% at 40 uM; and concentrations of 80 uM and above cause complete hemolysis.|||Exhibits hemolysis against human erythrocytes|||The document explicitly measured the hemolytic values of four peptides (TsAP-1, TsAP-2, and their cation-enhanced analogs TsAP-S1, TsAP-S2) on horse red blood cells. The peptides were incubated with a 4% horse red blood cell suspension for 120 minutes. 1% Triton X-100 was used as a 100% hemolysis positive control, and PBS as the 0% hemolysis negative control. The specific data are as follows: 1. Hemolytic activity of natural peptides (TsAP-1, TsAP-2) TsAP-1: Hemolytic activity was extremely low, only observed at the highest tested concentration (160 µM), with a hemolysis rate of 6.48%; at lower concentrations, the hemolysis rate was negligible. TsAP-2: Hemolytic activity was concentration-dependent: Concentration ≤15 µM: No hemolysis (0%). Concentration = 20 µM: Hemolysis rate 18%. Concentration = 40 µM: Hemolysis rate significantly increased to 86%. Concentration ≥80 µM: Complete hemolysis (100%). 2. Hemolytic activity of cation-enhanced analogs (TsAP-S1, TsAP-S2) Due to increased cationicity, both analogs exhibited significantly higher hemolytic activity than the natural peptides and showed similar concentration-dependent characteristics: Concentration = 5 µM: Both caused notable hemolysis, with a hemolysis rate of approximately 28%-30%. Concentration ≥20 µM: Both achieved complete hemolysis (100%). 3. Supplementary related conclusions Hemolytic activity is positively correlated with cationicity and helicity: the natural peptides (TsAP-1, TsAP-2) have a net charge of 2 and low hemolytic activity; the analogs (TsAP-S1, TsAP-S2) have a net charge increased to 6 and α-helix content increased from 58.82%-76.47% to 88.24%, with significantly enhanced hemolytic activity. Safety differences: TsAP-1, due to its extremely low hemolytic activity, is safer for antimicrobial applications; while TsAP-2 and the two analogs have stronger antibacterial/antitumor activity, the risk of hemolysis at high concentrations may limit their systemic application, making them more suitable for local use.|||Exhibits hemolysis against human erythrocytes|||not hemolytic at 15 uM, but it caused 50% hemolysis (HC50 at ~30 uM and 100% hemolysis at 80 uM (Hemolytic)." "Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. Pub-Med.|||Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. Pub-Med.||Guilhelmelli F et al., 2016|||Q5G8B5|||23770440|||27917162|||Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. Pub-Med.|||Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8.|||23770440|||27917162|||Biochimie . 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003. Epub 2013 Jun 14.||see ref for structure||Guilhelmelli F et al., 2016" 17 L FPDB00808 4532|||4533|||4534|||4535|||4536|||4537|||4538|||4539|||4540|||4541|||4542|||4543|||4544|||4545|||4546|||4547|||4548|||4549|||4550|||4571|||4574|||AP00783|||AP00783|||Pleurocidin-like peptide YT2|||DRAMP02359|||Pleurocidin-like peptide YT2|||AP00783 RWGKWFKKATHVGKHVGKAALTAYL 5% cytotoxic at 10 uM||20-30% cytotoxic at 25 uM||40-50% cytotoxic at 50 uM||~0% cytotoxic at 5 uM||10% cytotoxic at 10 uM||20% cytotoxic at 25 uM||20% cytotoxic at 10 uM||70-80% cytotoxic at 25 uM||80-85% cytotoxic at 50 uM||10% cytotoxic at 5 uM||50% cytotoxic at 10 uM||80% cytotoxic at 25 uM||80-90% cytotoxic at 50 uM||30-40% cytotoxic at 5 uM||60-70% cytotoxic at 10 uM||80-90% cytotoxic at 25 uM||85-90% cytotoxic at 50 uM||70% cytotoxic at 50 uM||60-70% cytotoxic at 50 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibacterial||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 4 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 2 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 2 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 4 ug/ml||Anti-E. coli UB1005, activity value is MIC = 4 ug/ml||Anti-E. coli DC2, activity value is MIC = 4 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus C623, activity value is MIC = 64 ug/ml||Anti-A. salmonicida 99-1, activity value is MIC = 4 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 2 ug/ml||Anti-E. coli CGSC 4908, activity value is MIC = 4 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 64 ug/ml||Anti-MRSA C623, activity value is MIC = 64 ug/ml||Anti-C. albicans C627, activity value is MIC = 16 ug/ml||Anti-A. salmonicida 99-1, activity value is MIC = 4 uM||Anti-A. salmonicida 97-4, activity value is MIC = 2 uM||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 uM||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 uM||Anti-P. aeruginosa K799, activity value is MIC = 4 uM||Anti-P. aeruginosa Z61, activity value is MIC = 2 uM||Anti-E. coli CGSC4908 or UB1005 or DC2, activity value is MIC = 4 uM||Anti-S. epidermidis C621 or MRSA, activity value is MIC = 64 uM||Anti-and C. albicans C627, activity value is MIC = 16 uM Yellowtail flounder YT2, Pleuronectes ferruginea Storer|||Yellowtail flounder YT2, Pleuronectes ferruginea Storer|||Limanda ferruginea [Yellowtail flounder]|||Limanda ferruginea (Yellowtail flounder YT2)|||Limanda ferruginea [Yellowtail flounder]|||Yellowtail flounder YT2, Pleuronectes ferruginea Storer N/A A. salmonicida 99-1 ( MIC = 4 ug/ml), A. salmonicida 97-4 ( MIC = 2 ug/ml), S. enterica serovar Typhimurium MS7953s ( MIC = 2 ug/ml), S. enterica serovar Typhimurium 14028s ( MIC = 8 ug/ml), P. aeruginosa K799 ( MIC = 4 ug/ml), P. aeruginosa Z61 ( MIC = 2 ug/ml), E. coli CGSC 4908 ( MIC = 4 ug/ml), E. coli UB1005 ( MIC = 4 ug/ml), E. coli DC2 ( MIC = 4 ug/ml), S. epidermidis C621 ( MIC = 64 ug/ml), MRSA C623 ( MIC = 64 ug/ml), C. albicans C627 ( MIC = 16 ug/ml) Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed. 25 L FPDB00889 AP02034 EQCREEEDDRB Anti-Disk diffusion assay: only fraction SU2 showed antifungal activity. It inhibited mycelial growth in M. arachidicola, activity value is IC50 = 1.2 uM||Antiviral||Antifungal||Anti-HIV Cocos nucifera N/A N/A "Peptides. 2005 Dec;26(12):2392-6. doi: 10.1016/j.peptides.2005.05.009.|||Peptides . 2005 Dec;26(12):2392-6. doi: 10.1016/j.peptides.2005.05.009.|||Peptides. 2005 Dec;26(12):2392-6. PubMed" 11 FPDB00898 AP00155|||DRAMP02912|||Cathelin-related peptide SC5|||AP00155 RGLRRLGRKIAHGVKKYGPTVLRIIRIAG Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anti-E. coli ATCC 25922 or ML-35 or D21, activity value is MIC = 0.12||Anti-S. enterica serovar typhimurium ATCC 14028, activity value is MIC = 0.25 uM||Anti-P. aeruginosa ATCC 27853 or 2 clinical isolates, activity value is MIC = 0.25||Anti-S. marcescens ATCC 8100, activity value is MIC = 0.25 uM||Anti-P-vulgaris ATCC 13315, activity value is MIC > 80 uM||Anti-S. aureus ATCC 25923 or Cowan 1 MRSA clinical isolate, activity value is MIC = 0.5||Anti-S. epidermidis ATCC 12228, activity value is MIC = 0.25 uM||Anti-E. faecalis ATCC 29212 or V clinical isolate, activity value is MIC = 1 uM||Anti-B. megaterium Bm11, activity value is MIC = 0.25 uM||Anti-C. albicans clinical isolate, activity value is MIC = 4 uM||Anti-C. neoformans 3 clinical isolates, activity value is MIC = 1 uM||Anti-and R. rubra, activity value is MIC = 0.5 uM||Anti-Escherichia coli DH5a, activity value is MIC = 0.1 uM||Anti-Escherichia coli ML-35p, activity value is MIC = 0.18 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 0.17 uM||Anti-Pseudomonas aeruginosa MR3007, activity value is MIC = 0.34 uM||Anti-Staphylococcus aureus ATCC 33591, activity value is MIC = 1.24 uM||Anti-Staphylococcus aureus 93918, activity value is MIC = 0.31 uM||Anti-Escherichia coli ML-35p, activity value is MIC = 0.12 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 0.08 uM||Anti-Pseudomonas aeruginosa MR3007, activity value is MIC = 0.18 uM||Anti-Staphylococcus aureus ATCC 33591, activity value is MIC = 0.65 uM||Anti-Staphylococcus aureus 93918, activity value is MIC = 0.43 uM||Anti-Staphylococcus aureus 25923, activity value is MIC = 5||Anti-Pseudomonas aeruginosa 27853, activity value is MIC = 5||Anti-Klebsiella pneumoniae 13883, activity value is MIC = 2.5||Anti-Candida albicans 14053, activity value is MIC = 10||Anti-pmid-10768969[ Pseudomonas aeruginosa PAO1, activity value is MIC = 0.17 uM||Anti-MRSA ATCC 33591, activity value is MIC = 1.24 uM sheep leukocytes; Ovis aries|||Ovis aries (Sheep)|||Ovis aries [Sheep]|||sheep leukocytes; Ovis aries Helix N/A "FEBS Lett. 1995 Dec 4;376(3):225-8. PubMed.|||1995 Dec 4;376(3):225-8. doi: 10.1016/0014-5793(95)01285-3.||Skerlavaj et al., 1999||Blower et al., 2018||Sousa et al., 2017|||Comparative Study FEBS Lett . 1995 Dec 4;376(3):225-8. doi: 10.1016/0014-5793(95)01285-3.||Skerlavaj et al., 1999||Blower et al., 2018||Sousa et al., 2017|||Protein Eng. 2002 Mar;15(3):225-232.||Ref.8549789|||8549789|||FEBS Lett. 1995 Dec 4;376(3):225-8. doi: 10.1016/0014-5793(95)01285-3.||Skerlavaj et al., 1999||Blower et al., 2018||Sousa et al., 2017" 29 FPDB00900 AP00276|||AP00276|||Clavanin-A|||Clavanin A|||ClavA|||DRAMP02597|||Clavanin-A|||Clavanin A|||AP00276|||DRAMP02597 VFQFLGKIIHHVGNFVHGFSHVF Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-L. monocytogenes EGD, activity value is MIC = 0.2||Anti-and P. aeruginosa MR3007, activity value is MIC = 0.4||Antibacterial||Antimicrobial||Anti-Gram+||Antifungal ; E.coli||L.monocytes||C.albicans sea squirts, and sea pork, invertebrate Styela clava|||sea squirts, and sea pork, invertebrate Styela clava|||Styela clava [Sea squirt]|||Styela clava [Sea squirts]|||Styela clava (Sea squirt)|||Styela clava [Sea squirts]|||sea squirts, and sea pork, invertebrate Styela clava|||Styela clava (Sea squirt) Helix||Alpha helix E. Coli (MIC=64 uM )|||Their hemolytic activity against human red blood cells was less than 10% up to 50 uM. "FEBS Lett. 1997; 400:158-162. PubMed.|||FEBS Lett . 1997 Jan 3;400(2):158-62. doi: 10.1016/s0014-5793(96)01374-9.||Lee IH et al., 1997|||9001389|||28712894|||28226206|||FEBS Lett. 1997 Jun 30;410(2-3):490-492.|||9001389|||28712894|||FEBS Lett. 1997; 400:158-162. doi: 10.1016/s0014-5793(96)01374-9.||Lee IH et al., 1997|||FEBS Lett. 1997 Jun 30;410(2-3):490-492. FEBS Lett. 1997 Jan 3;400(2):158-162." 23 FPDB00901 AP00278|||AP00278|||Clavanin-C|||DRAMP02599|||Clavanin-C|||DRAMP02599 VFHLLGKIIHHVGNFVYGFSHVF Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibacterial||Antimicrobial||Anti-Gram+||Antifungal ; E.coli||L.monocytes||C.albicans invertebrate Styela clava|||invertebrate Styela clava|||Styela clava [Sea squirt]|||Styela clava (Sea squirt) Alpha helix N/A "FEBS Lett. 1997; 400:158-162. PubMed.|||FEBS Lett . 1997 Jan 3;400(2):158-62. doi: 10.1016/s0014-5793(96)01374-9.|||9001389|||FEBS Lett. 1997 Jun 30;410(2-3):490-492.|||9001389|||FEBS Lett. 1997 Jun 30;410(2-3):490-492. FEBS Lett. 1997 Jan 3;400(2):158-162." 23 FPDB00907 AP00516|||AP00516|||Lycotoxin-1|||DRAMP03278|||Lycotoxin-1|||AP00516 IWLTALKFLGKHAAKHLAKQQLSKL Anti-Gram+ & Gram-||Antifungal||candidacidal||Insecticidal||Anti-MRSA||Enzyme inhibitor||Anti-Gram-negative bacteria E. coli D31, activity value is MIC = 10||Anti-C. albicans clinical isolate . Also active against S. aureus USA300 MRSA, activity value is MIC = 3.1 uM||Anti-E. coli, activity value is MIC = 25 uM||Anti-B. subtilis, activity value is MIC = 6.25 uM||Anti-and P. aeruginosa, activity value is MIC = 6.25 uM||Antibacterial||Anti-Bacillus thuringiensis subsp. Israelensis, activity value is MIC < 5 uM||Anti-Escherichia coli D31, activity value is MIC = 10||Anti-Escherichia coli DH5, activity value is MIC = 80||Anti-Candida albicans clinical isolate, activity value is MIC = 100 Wolf Spider, Hogna carolinensis, (old)Lycosa carolinensis|||Wolf Spider, Hogna carolinensis, (old)Lycosa carolinensis|||Hogna carolinensis [Carolina wolf spider]|||Hogna carolinensis (Carolina wolf spider) (Lycosa carolinensis)|||Hogna carolinensis [Carolina wolf spider]|||Wolf Spider, Hogna carolinensis, (old)Lycosa carolinensis Alpha helix "The document provides clear hemolysis data for spider venom antimicrobial peptides (lycotoxins) and the control peptide magainin B through hemolysis assays (using rabbit red blood cells as the test subject). The core data are as follows: 1. Hemolytic activity and concentration dependence of key peptides Testing conditions: Rabbit red blood cells were incubated with peptides in PBS for 1 hour. Hemoglobin release was measured at 570 nm. ""Water-lysed red blood cells"" served as the 100% hemolysis control, and ""PBS incubation"" served as the 0% hemolysis control. lycotoxin I (spider-derived antimicrobial peptide): No hemolytic activity concentration: <30 μM (no hemolysis detected below this concentration). Significant hemolytic concentration: >100 μM, with hemolysis rate increasing with concentration. Specific data: At 200 μM, hemolysis rate is 55% (calculated as: (absorbance of lycotoxin I group / absorbance of water-lysed group) × 100%). magainin B (control, frog-derived antimicrobial peptide): No hemolytic activity concentration: <30 μM (same as lycotoxin I). Significant hemolytic concentration: >100 μM, but hemolytic activity is weaker than lycotoxin I. Specific data: At 200 μM, hemolysis rate is 35%. 2. Key notes The hemolysis curve trends of the two peptides are consistent (increased concentration → increased hemolysis rate), but at the same high concentration, lycotoxin I exhibits significantly higher hemolytic activity than magainin B (55% vs. 35% at 200 μM). The document does not provide hemolysis data for lycotoxin II; it only clearly states that there are no relevant test results. The 50% hemolytic concentration (HC₅₀) was not calculated, and only specific concentrations (200 μM) with corresponding hemolysis rates and the thresholds for “no hemolysis/significant hemolysis” are given.|||Lycotoxin I: No obvious hemolysis at <30 μM, significant hemolysis at 100 μM, and a hemolysis rate of 55% at 200 μM; • Magainin B: No obvious hemolysis at <30 μM, significant hemolysis at 100 μM, and a hemolysis rate of 35% at 200 μM.|||Within the concentration range of ≤30 uM, Lycotoxin I exhibits no significant hemolytic effect on rabbit red blood cells, with a hemolysis rate of <5%. It begins to show significant hemolysis at 100 uM, and the hemolysis rate reaches 55% at 200 uM." "J Biol Chem. 1998 Jan 23;273(4):2059-66. PubMed.|||J Biol Chem . 1998 Jan 23;273(4):2059-66. doi: 10.1074/jbc.273.4.2059.||this ref||Menousek J et al 2012 Int J Antimicrob Agents 39:402|||9442044|||J Pept Sci. 2008 Apr;14(4):528-534.|||9442044|||J Biol Chem. 1998 Jan 23;273(4):2059-66. PubMed.||this ref||Menousek J et al 2012 Int J Antimicrob Agents 39:402" 25 FPDB00914 AP00575|||AP00575|||Brevinin -2 Gra , Brevinin-2E-OG1, Brevinin-2E-OG6|||Brevinin-2JD|||DRAMP01914|||Brevinin -2 Gra , Brevinin-2E-OG1, Brevinin-2E-OG6|||Brevinin-2JD GLLDTFKNLALNAAKSAGVSVLNSLSCKLSKTC Anti-Gram+ & Gram-||Anti-MRSA||Anti-E. coli, activity value is MIC = 12.5||Anti-S. aureus MRSA, activity value is MIC = 19||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus, activity value is MIC = 50 uM||Anti-E. coli, activity value is MIC = 12.5 uM||Anti-S. aureus, activity value is MIC = 50 uM||Anti-C. albicans, activity value is MIC > 100 uM||Anti-Staphylococcus aureus, activity value is MIC = 64 ug/ml||Anti-CIB 85462, activity value is MIC = 64 ug/ml||Anti-Escherichia coli, activity value is MIC = 128 ug/ml||Anti-CIB 84492, activity value is MIC = 128 ug/ml||Anti-Candida albicans, activity value is MIC = 64 ug/ml||candidacidal Rana grahami, Odorrana jingdongensis, Asia|||Rana grahami, Odorrana jingdongensis, Asia|||Rana grahami [Yunnanfu frog]|||Odorrana jingdongensis [Jingdong frog]|||Rana grahami (Asian frog)|||Rana grahami [Yunnanfu frog]|||Odorrana jingdongensis [Jingdong frog] N/A "Seven antimicrobial peptides isolated from the skin of the Asian frog (Rana grahami) exhibited the following hemolytic values, expressed as the concentration (LC₅₀) required to induce 50% hemolysis of human red blood cells: The hemolytic LC50 value of esculentin-1GRa is 210 µM. The hemolytic LC50 value of Brevinin-2GRa is 140 µM. The hemolytic LC50 value of Brevinin-2GRb is 180 µM. The hemolytic activity of Brevinin-1GRa was not detected (ND); The hemolytic LC50 value of Brevinin-2GRc is 100 µM. The hemolytic LC50 value of Nigrocin-2GRa is 295 µM. The hemolytic LC₅₀ value of Nigrocin-2GRb is 40 µM, making it the most hemolytic among these seven antimicrobial peptides; concurrently, it also exhibits the highest antimicrobial activity, with MIC values of 3 µM against Escherichia coli and 12.5 µM against Staphylococcus aureus. The hemolytic LC₅₀ value of Nigrocin-2GRc is >500 μM, indicating the weakest hemolytic activity; its antibacterial activity is also relatively low, with an MIC of 50 μM against Escherichia coli and MICs >100 μM against Staphylococcus aureus and Candida albicans. This suggests a certain correlation between the peptide’s hemolytic activity and its antibacterial potency.|||The document mentions hemolytic-related content. The following are the specific hemolytic values: - Esculentin-1GRa: The concentration causing 50% hemolysis of human red blood cells (LC₅₀) is 210 μM. - Brevinin-2GRa: LC₅₀ is 140 μM. - Brevinin-2GRb: LC₅₀ is 180 μM. - Brevinin-2GRc: LC₅₀ is 100 μM. - Nigrocin-2GRa: LC₅₀ is 295 μM. - Nigrocin-2GRb: LC₅₀ is 40 μM. - Nigrocin-2GRc: LC₅₀ is greater than 501 μM.|||[Ref.16621155] LC50=140 uM against human erythrocytes." "Peptides 2006; 27: 2111-2117. PubMed.|||Peptides . 2006 Sep;27(9):2111-7. doi: 10.1016/j.peptides.2006.03.002. Epub 2006 Apr 18.|||16621155 , 17272268|||22917879|||Peptides. 2006 Sep;27(9):2111-2117.|||16621155|||16621155 , 17272268|||22917879" 33 FPDB00916 AP00587|||AP00587|||Brevinin-2TSa|||DRAMP02033|||AP00587 GIMSLFKGVLKTAGKHVAGSLVDQLKCKITGGC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-including E. coli ATCC25922, activity value is MIC = 3 uM||Anti-E. cloacae HNTCC 5300, activity value is MIC = 6 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 6 uM||Anti-K. pneumoniae KK3 9904, activity value is MIC = 6 uM||Anti-S. aureus NCTC 8325 or MRSA, activity value is MIC = 12.5||Anti-S. epidermidis RP62A, activity value is MIC = 12.5 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 25 uM||Anti-C. albicans ATCC 90028, activity value is MIC = 100 uM||Antibacterial||Anti-Escherichia coli ATCC 25922, activity value is MIC = 3 uM||Anti-Klebsiella pneumoniae KK3 9904, activity value is MIC = 6 uM||Anti-Enterobacter cloacae HNTCC 53001, activity value is MIC = 6 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 6 uM||Anti-Proteus mirabilis ATCC 25933, activity value is MIC > 100 uM||Anti-Staphylococcus aureus NCTC 8325, activity value is MIC = 12.5 uM||Anti-Methicillin-resistant Staphylococcus aureus T7/20, activity value is MIC = 25 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 12.5 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 25 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 100 uM||Anti-P.mirabilis ATCC 25933, activity value is MIC > 100 uM skin, Rana tsushimensis, Asia|||Rana tsushimensis, Asia|||Rana tsushimensis|||Rana tsushimensis (Tsushima brown frog)|||skin, Rana tsushimensis, Asia|||Rana tsushimensis, Asia N/A "The antimicrobial peptides isolated from the skin of the Tsushima brown frog (Rana tsushimensis) have the following hemolytic values (expressed as the concentration causing 50% hemolysis of human red blood cells, LD_{50}): The hemolytic value LD_{50} of Brevinin-1TSa is 12 µM. This peptide has strong hemolytic activity; although it shows inhibitory activity against various Gram-positive bacteria, Gram-negative bacteria, and Candida albicans, its high hemolytic activity may limit its therapeutic application. The hemolytic value LD_{50} of Brevinin-2TSa is 100 µM, with significantly lower hemolytic activity. It also exhibits broad-spectrum inhibitory activity against multiple pathogenic bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) (MIC ≤ 25 µM), making it a more promising candidate for drug development. For the Temporin family peptides Temporin-1TSa, Temporin-1TSb, Temporin-1TSc, and Temporin-1TSd, the document only mentions the antimicrobial activity of some members and does not report their hemolytic data.|||The document mentioned hemolysis-related content, and the following are the specific hemolytic values: - Brevinin-1TSa: The concentration causing 50% hemolysis of human red blood cells (LD₅₀) is 12 μM. - Brevinin-2TSa: LD₅₀ is 100 μM.|||Erythrocytes ( LD50 = 100 uM)|||In Document 10 (Comparative Biochemistry and Physiology, Part C 2006), the LD₅₀ of brevinin-1TSa, isolated from skin extracts of the Tsushima frog (Rana tsushimensis), on human red blood cells is 12 µM, and the LD₅₀ of brevinin-2TSa on human red blood cells is 100 µM.|||[Ref.16413829] LD50=100 uM against human erythrocytes|||LD₅₀=100 uM" Comp. Biochem. Physiol. part C, 2006; 143: 42-49. PubMed.|||Broad-spectrum growth inhibitory activity against a range of Gram-negative and Gram-positive bacteria, including E. coli ATCC25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC 90028 (MIC 100 uM).|||16413829|||Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49.||Ref.16413829|||16413829||Ref.16413829|||Comp. Biochem. Physiol. part C, 2006; 143: 42-49. PubMed. 33 FPDB00917 AP00588|||AP00588|||Brevinin-1TSa|||DRAMP02032|||AP00588 FLGSIVGALASALPSLISKIRN Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anti-Much less active than 2TSa . active against S. epidermidis RP62A, activity value is MIC = 12.5 uM||Anti-E. coli ATCC25922, activity value is MIC = 25 uM||Anti-S. aureus NCTC 8325 or MRSA T7/20, activity value is MIC = 25 uM||Anti-E. cloacae HNTCC 5300, activity value is MIC = 50 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 50 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 50 uM||Anti-Streptococcus group B HNTCC 80130, activity value is MIC = 50 uM||Anti-C. albicans ATCC 90028, activity value is MIC = 50 uM||Antibacterial||Anti-Escherichia coli ATCC 25922, activity value is MIC = 25 uM||Anti-Klebsiella pneumoniae KK3 9904, activity value is MIC > 100 uM||Anti-Enterobacter cloacae HNTCC 53001, activity value is MIC = 50 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 50 uM||Anti-Proteus mirabilis ATCC 25933, activity value is MIC > 100 uM||Anti-Staphylococcus aureus NCTC 8325, activity value is MIC = 25 uM||Anti-Methicillin-resistant Staphylococcus aureus T7/20, activity value is MIC = 25 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 12.5 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 50 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 50 uM||Anti-K.pneumoniae KK3 9904, activity value is MIC > 100 uM||Anti-P.mirabilis ATCC 25933, activity value is MIC > 100 uM skin, Rana tsushimensis, Asia|||Rana tsushimensis, Asia|||Rana tsushimensis|||Rana tsushimensis (Tsushima brown frog)|||skin, Rana tsushimensis, Asia|||Rana tsushimensis, Asia N/A "The antimicrobial peptides isolated from the skin of the Tsushima brown frog (Rana tsushimensis) have the following hemolytic values (expressed as the concentration causing 50% hemolysis of human red blood cells, LD_{50}): The hemolytic value LD_{50} of Brevinin-1TSa is 12 µM. This peptide has strong hemolytic activity; although it shows inhibitory activity against various Gram-positive bacteria, Gram-negative bacteria, and Candida albicans, its high hemolytic activity may limit its therapeutic application. The hemolytic value LD_{50} of Brevinin-2TSa is 100 µM, with significantly lower hemolytic activity. It also exhibits broad-spectrum inhibitory activity against multiple pathogenic bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) (MIC ≤ 25 µM), making it a more promising candidate for drug development. For the Temporin family peptides Temporin-1TSa, Temporin-1TSb, Temporin-1TSc, and Temporin-1TSd, the document only mentions the antimicrobial activity of some members and does not report their hemolytic data.|||The document mentioned hemolysis-related content. The following are the specific hemolysis values: - Brevinin-1TSa: The concentration that caused 50% hemolysis of human red blood cells (LD₅₀) is 12 μM. - Brevinin-2TSa: LD₅₀ is 101 μM.|||Erythrocytes ( LD50 = 12 uM)|||In Document 10 (Comparative Biochemistry and Physiology, Part C 2006), the LD₅₀ of brevinin-1TSa, isolated from skin extracts of the Tsushima frog (Rana tsushimensis), on human red blood cells is 12 µM, and the LD₅₀ of brevinin-2TSa on human red blood cells is 100 µM.|||[Ref.16413829]LD50=12 uM against human erythrocytes|||LD₅₀=12 uM|||highly hemolytic HC50 12 uM." "Comp. Biochem. Physiol. part C, 2006; 143: 42-49. PubMed.|||Comp Biochem Physiol C Toxicol Pharmacol . 2006 May;143(1):42-9. doi: 10.1016/j.cbpc.2005.11.022. Epub 2006 Jan 18.|||16413829|||Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49.||Ref.16413829|||16413829||Ref.16413829|||Comp. Biochem. Physiol. part C, 2006; 143: 42-49. PubMed." 22 FPDB00918 AP00595|||AP00595|||Temporin-1CSb|||Vespid chemotactic peptide 5h|||Vespid chemotactic peptide 5h|||AP00595|||DRAMP01816 FLPIIGKLLSGLL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Antibiofilm||Anti-S. aureus ATCC 25923 or ATCC 12493 MRSA and 2 clincal strains, activity value is MIC = 1.2||Anti-negative E. coli ATCC25922, activity value is MIC = 2.5 uM||Anti-E. cloacae ATCC13047, activity value is MIC = 2.5 uM||Anti-K. pneumoniae ATCC700603, activity value is MIC = 10 uM||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 10 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 40 uM||Anti-B. dysenteriae, activity value is MIC = 20 uM||Anti-E. coli IS 37#, activity value is MIC = 20 uM||Anti-E. coli IS 117# or 218#, activity value is MIC = 20 uM||Anti-P. aeruginosa IS 350#, activity value is MIC = 5 uM||Anti-K. pneumoniae IS 59#, activity value is MIC = 40 uM||Anti-C. albicans ATCC2002 or ATCC90028, activity value is MIC = 10 uM||Anti-and C. parapsilosis ATCC22019, activity value is MIC = 2.5 uM||Anti-E.coli ATCC 8739, activity value is MIC > 256 uM||Anti-K.pneumoniae ATCC 43816, activity value is MIC > 512 uM||Anti-P.aeruginosa ATCC 9027, activity value is MIC > 512 uM||Anti-and yeast C.albicans ATCC 10231, activity value is MIC = 32 uM||Anti-E. coli, activity value is MIC = 128 uM||Anti-S. aureus, activity value is MIC = 8 uM||Anti-E.coli ATCC 25922, activity value is MIC = 30 ug/ml||Anti-S.aureus ATCC 2592, activity value is MIC = 5 ug/ml||Anti-C.albicans ATCC 2002, activity value is MIC = 25 ug/ml||Antibacterial||Anti-Escherichia coli, activity value is MIC = 128 uM||Anti-Staphylococcus aureus, activity value is MIC = 8 uM skin secretions, Rana cascadae, North America. Also venom gland, the social wasp, Vespa mandarinia, also Vespa tropica, Asia|||North America, Rana cascadae; venom gland, the social wasp, Vespa mandarinia, also Vespa tropica|||Rana cascadae|||Vespa magnifica [Hornet]|||Vespa magnifica [Hornet]|||skin secretions, Rana cascadae, North America. Also venom gland, the social wasp, Vespa mandarinia, also Vespa tropica, Asia|||Rana cascadae (Cascades frog) N/A "The document clearly provides the hemolytic values of six antimicrobial peptides isolated from the skin of the Cascades frog (Rana cascadae) (expressed as the concentration causing 50% hemolysis of human red blood cells, LD_{50}), with specific data as follows: The hemolytic value LD_{50} of Ranatuerin-2CSa is 150 µM, its minimum inhibitory concentration (MIC) against Escherichia coli is 4 µM, and against Staphylococcus aureus is 8 µM. It has broad-spectrum antibacterial activity but low hemolysis; Brevinin-1CSa has a hemolytic value LD_{50} of 5 µM, the strongest hemolysis among these six peptides, with an MIC of 32 µM against E. coli and 2 µM against S. aureus; Temporin-1CSa has a hemolytic value LD_{50} of 75 µM, an MIC of 128 µM against E. coli, and 8 µM against S. aureus; Temporin-1CSb has a hemolytic value LD_{50} of 95 µM, with MICs of 128 µM against E. coli and 8 µM against S. aureus; Temporin-1CSc has a hemolytic value LD_{50} > 300 µM, the weakest hemolysis, with an MIC > 128 µM against E. coli and 64 µM against S. aureus; Temporin-1CSd has a hemolytic value LD_{50} of 50 µM, with an MIC of 64 µM against E. coli and 16 µM against S. aureus.|||The document mentions content related to hemolysis. The specific hemolytic values are as follows: - Ranatuerin-2CSa: The concentration that causes 50% hemolysis of human red blood cells (LD₅₀) is 150 μM. - Brevinin-1CSa: LD₅₀ is 5 μM. - Temporin-1CSa: LD₅₀ is 75 μM. - Temporin-1CSb: LD₅₀ is 95 μM. - Temporin-1CSd: LD₅₀ is 50 μM.|||The hemolytic values detected for antimicrobial peptides in the skin secretions of the Cascades frog (Rana cascadae), as explicitly mentioned in the document (expressed as LC_{50} for human red blood cells), are as follows: The hemolytic value LC_{50} of Ranatuerin-2CSa is 150 µM; The hemolytic value LC_{50} of Brevinin-1CSa is 5 µM; The hemolytic value LC_{50} of Temporin-1CSa is 75 µM; The hemolytic value LC_{50} of Temporin-1CSb is 95 µM; The hemolytic value LC_{50} of Temporin-1CSc is greater than 300 µM; The hemolytic value LC_{50} of Temporin-1CSd is 50 µM. Note: LC_{50} refers to the peptide concentration that causes 50% red blood cell hemolysis; lower values indicate stronger hemolytic activity. Among them, Brevinin-1CSa has the strongest hemolytic activity (LC_{50} = 5 µM), and Temporin-1CSc has the weakest hemolytic activity (LC_{50} > 300 µM).|||LC₅₀=95 uM" "Peptides 2007; 28: 1268-1274. PubMed.|||Peptides . 2007 Jun;28(6):1268-74. doi: 10.1016/j.peptides.2007.03.010. Epub 2007 Mar 27.|||17451843" 13 FPDB00922 AP00727|||AP00727|||Arenicin-1|||AR|||Arcycl|||DRAMP03173|||AP00727 RWCVYAYVRVRGVLVRYRRCW Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Anti-L. monocytogenes EGD, activity value is MIC = 0.6 ug/ml||Anti-negative E. coli ML-35p, activity value is MIC = 4 ug/ml||Antibacterial||Anti-Escherichia coli ML35p, activity value is MIC = 1||Anti-E. coli ATCC 25922, activity value is MIC = 2 uM||Anti-E. coli M15, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 2 uM||Anti-Listeria monocytogenes EGD, activity value is MIC = 1||Anti-Staphylococcus aureus 710A, activity value is MIC = 2 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2 uM||Anti-MRSA ATCC 33591, activity value is MIC = 4 uM||Anti-P. aeruginosa c.i, activity value is MIC = 4 uM||Anti-Acinetobacter baumanii c.i, activity value is MIC = 4 uM||Anti-Staphylococcus intermidius, activity value is MIC = 8 uM||Anti-S. aureus c.i, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-Listeria monocytogenes EGD, activity value is MIC = 2 uM||Anti-P. aeruginosa c.i, activity value is MIC = 2 uM||Anti-Staphylococcus intermidius, activity value is MIC = 4 uM||Anti-S. aureus c.i, activity value is MIC = 4 uM||Anti-Listeria monocytogenes EGD, activity value is MIC = 0.6 ug/ml||Anti-Escherichia coli ML-35p, activity value is MIC = 4 ug/ml||Anti-E. coli WBB01, activity value is MIC = 300 uM||Anti-E. coli ATCC 23716, activity value is MIC = 600 uM||Anti-Salmonella enterica R595, activity value is MIC = 300 uM||Anti-S. enterica R60, activity value is MIC = 1250 uM||Anti-Proteus mirabilis R45, activity value is MIC = 600 uM Arenicola marina|||Arenicola marina|||Synthetic construct|||Arenicola marina [Lugworm]|||Arenicola marina (Lugworm) (Lumbricus marinus)|||Arenicola marina Beta||Beta strand (2 strands; 16 residues) N/A "FEBS Lett 2004; 577: 209-214. PubMed|||2004 Nov 5;577(1-2):209-14. doi: 10.1016/j.febslet.2004.10.012.|||FEBS Lett . 2004 Nov 5;577(1-2):209-14. doi: 10.1016/j.febslet.2004.10.012.|||17935487|||31234579|||Biochem J. 2008 Feb 15;410(1):113-122.|||FEBS Lett 2004; 577: 209-214. PubMed" 21 FPDB00925 AP00782|||AP00782|||Winter flounder 4|||DRAMP02358|||Winter flounder 4|||AP00782 GWGSIFKHGRHAAKHIGHAAVNHYL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibacterial||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 4 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 4 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS7953s, activity value is MIC = 4 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 64 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 4 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 4 ug/ml||Anti-E. coli UB1005, activity value is MIC = 4 ug/ml||Anti-E. coli DC2, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC > 64 ug/ml||Anti-Staphylococcus aureus C623, activity value is MIC = 32 ug/ml||Anti-A. salmonicida 99-1, activity value is MIC = 4 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 4 ug/ml||Anti-E. coli CGSC 4908, activity value is MIC = 4 ug/ml||Anti-S. epidermidis C621, activity value is MIC > 64 ug/ml||Anti-MRSA C623, activity value is MIC = 32 ug/ml||Anti-C. albicans C627, activity value is MIC = 32 ug/ml winter flounder 4 1.1, Pleuronectes americanus|||winter flounder 4 1.1, Pleuronectes americanus|||Pseudopleuronectes americanus [Winter flounder]|||Pseudopleuronectes americanus (Winter flounder 4-1.1)|||Pseudopleuronectes americanus [Winter flounder]|||winter flounder 4 1.1, Pleuronectes americanus N/A A. salmonicida 99-1 (MIC = 4 ug/ml), A. salmonicida 97-4 (MIC = 4 ug/ml), S. enterica serovar Typhimurium MS7953s (MIC = 4 ug/ml), S. enterica serovar Typhimurium 14028s (MIC = 64 ug/ml), P. aeruginosa K799 (MIC = 16 ug/ml), P. aeruginosa Z61 (MIC = 4 ug/ml), E. coli CGSC 4908 (MIC = 4 ug/ml), E. coli UB1005 (MIC = 4 ug/ml), E. coli DC2 (MIC = 2 ug/ml), S. epidermidis C621 (MIC >64 ug/ml), MRSA C623 (MIC = 32 ug/ml), C. albicans C627 (MIC = 32 ug/ml) Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed. .|||2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed. . 25 FPDB00927 AP00786|||NRC-12|||NRC-12|||AP00786 GWKKWFNRAKKVGKTVGGLAVDHYL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-A. salmonicida 99-1, activity value is MIC = 2 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 2 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-E. coli CGSC4908, activity value is MIC = 2 ug/ml||Anti-E. coli UB1005, activity value is MIC = 8 ug/ml||Anti-E. coli DC2, activity value is MIC = 2 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 8 ug/ml||Anti-MRSA C623, activity value is MIC = 16 ug/ml||Anti-C. albicans C627, activity value is MIC = 4 ug/ml||Anti-A. salmonicida 99-1, activity value is MIC = 2 uM||Anti-A. salmonicida 97-4, activity value is MIC = 2 uM||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 2 uM||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 8 uM||Anti-P. aeruginosa K799, activity value is MIC = 4 uM||Anti-P. aeruginosa Z61, activity value is MIC = 1 uM||Anti-E. coli CGSC4908, activity value is MIC = 2 uM||Anti-E. coli UB1005, activity value is MIC = 8 uM||Anti-E. coli DC2, activity value is MIC = 2 uM||Anti-S. epidermidis C621, activity value is MIC = 8 uM||Anti-methicillin-resistant S. aureus C623, activity value is MIC = 16 uM||Anti-C. albicans C627, activity value is MIC = 4 uM American plaice AP2, Hippoglossoides platessoides Fabricius|||Hippoglossoides platessoides [American plaice]|||Hippoglossoides platessoides [American plaice]|||American plaice AP2, Hippoglossoides platessoides Fabricius N/A N/A Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||Reference: Patel S, Stott I P, Bhakoo M, Elliott P (1988) Patenting computer-designed peptides. Journal of Computer-Aided Molecular Design, 12: 543–556.|||Reference: Patel S, Stott I P, Bhakoo M, Elliott P (1988) Patenting computer-designed peptides. Journal of Computer-Aided Molecular Design, 12: 543–556.|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed. 25 FPDB00928 AP00787 GWRLLLKKAEVKTVGKLALKHYL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA American plaice AP3, Hippoglossoides platessoides Fabricius N/A N/A Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003. 23 FPDB00930 AP00789|||AP00789|||Witch flounder GcSc4B7|||DRAMP02364|||Witch flounder GcSc4B7|||AP00789 GFWGKLFKLGLHGIGLLHLHL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-A. salmonicida 99-1, activity value is MIC = 8 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 16 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 4 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 4 ug/ml||Anti-E. coli CGSC 4908, activity value is MIC = 8 ug/ml||Anti-E. coli UB1005, activity value is MIC = 8 ug/ml||Anti-E. coli DC2, activity value is MIC = 8 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 4 ug/ml||Anti-MRSA C623, activity value is MIC = 4 ug/ml||Anti-C. albicans C627, activity value is MIC = 16 ug/ml||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 32 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS7953s, activity value is MIC = 16 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC > 64 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 32 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 8 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 16 ug/ml||Anti-E. coli UB1005, activity value is MIC = 16 ug/ml||Anti-E. coli DC2, activity value is MIC = 16 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus C623, activity value is MIC = 16 ug/ml witch flounder GcSc4B7, Glyptocephalus cynoglossus L.|||witch flounder GcSc4B7, Glyptocephalus cynoglossus L.|||Glyptocephalus cynoglossus [Witch]|||Glyptocephalus cynoglossus (Witch flounder GcSc4B7)|||witch flounder GcSc4B7, Glyptocephalus cynoglossus L. N/A N/A Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed. 21 FPDB00931 AP00790|||AP00790|||Witch flounder GC3.8-t|||DRAMP02352|||Witch flounder GC3.8-t|||AP00790 GWKKWLRKGAKHLGQAAIK Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-A. salmonicida 99-1, activity value is MIC = 2 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 1 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 0.5 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-E. coli CGSC 4908, activity value is MIC = 1 ug/ml||Anti-E. coli UB1005, activity value is MIC = 2 ug/ml||Anti-E. coli DC2, activity value is MIC = 0.5 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 16 ug/ml||Anti-MRSA C623, activity value is MIC = 32 ug/ml||Anti-C. albicans C627, activity value is MIC = 8 ug/ml||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 2 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS7953s, activity value is MIC = 0.5 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 1 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus C623, activity value is MIC = 32 ug/ml witch flounder GC3.8-t, Glyptocephalus cynoglossus L.|||witch flounder GC3.8-t, Glyptocephalus cynoglossus L.|||Glyptocephalus cynoglossus [Witch]|||Glyptocephalus cynoglossus (Witch flounder GC3.8-t)|||witch flounder GC3.8-t, Glyptocephalus cynoglossus L. N/A N/A Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed. 19 FPDB00932 AP00791|||AP00791|||NRC-17|||DRAMP02365|||NRC-17|||AP00791 GWKKWLRKGAKHLGQAAIKGLAS Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibacterial||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 8 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 16 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS7953s, activity value is MIC = 4 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 4 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 8 ug/ml||Anti-E. coli UB1005, activity value is MIC = 8 ug/ml||Anti-E. coli DC2, activity value is MIC = 8 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus C623, activity value is MIC = 4 ug/ml||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 2 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 4 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 1 ug/ml||Anti-Escherichia coli DC2, activity value is MIC = 1 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 2 ug/ml||Anti-E. coli CGSC4908, activity value is MIC = 1 ug/ml||Anti-E. coli UB1005, activity value is MIC = 4 ug/ml||Anti-E. coli DC2, activity value is MIC = 1 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 32 ug/ml||Anti-MRSA C623, activity value is MIC = 16 ug/ml||Anti-C. albicans C627, activity value is MIC = 8 ug/ml witch flounder GC3.8, Glyptocephalus cynoglossus L.|||witch flounder GC3.8, Glyptocephalus cynoglossus L.|||Glyptocephalus cynoglossus L. [Witch]|||Glyptocephalus cynoglossus (Witch flounder GC3.8)|||witch flounder GC3.8, Glyptocephalus cynoglossus L. N/A Aeromonas salmonicida 99-1 ( MIC = 2 ug/ml ),Escherichia coli UB1005 ( MIC = 4 ug/ml ), Escherichia coli CGSC 4908 ( MIC = 1 ug/ml ), Escherichia coli DC2 ( MIC = 1 ug/ml ),Pseudomonas aeruginosa K799 ( MIC = 4 ug/ml ), P. aeruginosa Z61 ( MIC = 2 ug/ml ), E. coli CGSC4908 (MIC = 1 ug/ml), E. coli UB1005 (MIC = 4 ug/ml), E. coli DC2 (MIC = 1 ug/ml), S. epidermidis C621 (MIC = 32 ug/ml), MRSA C623 (MIC=16 ug/ml), C. albicans C627 (MIC =8 ug/ml) Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||Reference: Wang, C, Sun Z, Liu Y, Zhang X, Xu G (2007) A novel antimicrobial vermipeptide family from earthworm Eisenia fetida. Eur. J Soil Biol 2007; 43:S217-S134.|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.|||Reference: Wang, C, Sun Z, Liu Y, Zhang X, Xu G (2007) A novel antimicrobial vermipeptide family from earthworm Eisenia fetida. Eur. J Soil Biol 2007; 43:S217-S134.|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed. 23 FPDB00933 AP00792|||AP00792|||Pleurocidin-like peptide Hb26|||Pleurocidin-like peptide Hb26|||AP00792 FLGLLFHGVHHVGKWIHGLIHGHH Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibacterial||Anti-A. salmonicida 99-1, activity value is MIC = 64 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 16 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 64 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 8 ug/ml||Anti-E. coli CGSC 4908, activity value is MIC = 32 ug/ml||Anti-E. coli UB1005, activity value is MIC = 16 ug/ml||Anti-E. coli DC2, activity value is MIC = 32 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 8 ug/ml||Anti-MRSA C623, activity value is MIC = 8 ug/ml||Anti-C. albicans C627, activity value is MIC = 64 ug/ml Atlantic Halibut Hb26, Hippoglossus hippoglossus L.|||Atlantic Halibut Hb26, Hippoglossus hippoglossus L.|||Hippoglossus hippoglossus [Atlantic halibut]|||Hippoglossus hippoglossus [Atlantic halibut]|||Atlantic Halibut Hb26, Hippoglossus hippoglossus L. N/A A. salmonicida 99-1 ( MIC = 64 ug/ml), S. enterica serovar Typhimurium MS7953s ( MIC = 16 ug/ml), S. enterica serovar Typhimurium 14028s ( MIC = 64 ug/ml), P. aeruginosa K799 ( MIC = 32 ug/ml), P. aeruginosa Z61 ( MIC = 8 ug/ml), E. coli CGSC 4908 ( MIC = 32 ug/ml), E. coli UB1005 ( MIC = 16 ug/ml), E. coli DC2 ( MIC = 32 ug/ml), S. epidermidis C621 ( MIC = 8 ug/ml), MRSA C623 ( MIC = 8 ug/ml), C. albicans C627 ( MIC = 64 ug/ml), A. salmonicida 97-4 ( MIC = >64 ug/ml) Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||12878506|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed. 24 FPDB00934 AP00823|||AP00823|||CAMPSQ10996|||DRAMP01795 SILPTIVSFLSKVF Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anti-Staphylococcus aureus USA300, activity value is MIC = 3.1 uM||Anti-Staphylococcus epidermidis 1457, activity value is MIC = 3.1 uM||Anti-Bacillus subtilis 168, activity value is MIC = 6.3 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 12.5 uM||Anti-C. glabrata ATCC 2001, activity value is MIC = 12.5 uM||Anti-C. tropicalis ATCC 13803, activity value is MIC = 3.1 uM||Anti-Antinacterial activity was not reported due to a limited amount of material. We filled up this gap by using a synthetic peptide. Active against S. aureus USA300, activity value is MIC = 3.1 uM||Anti-S. epidermidis 1457, activity value is MIC = 3.1 uM||Anti-B. subtilis 168, activity value is MIC = 6.2 uM||Anti-C. albicans, activity value is MIC = 50 uM||Antimicrobial||Antibacterial Rana grylio, North America|||Rana grylio, North America|||Rana grylio [North American pig frog]|||Rana grylio (North American pig frog) N/A "The document explicitly mentions the hemolytic values of five antimicrobial peptides isolated from the skin extracts and secretions of the North American bullfrog (Rana grylio), which represent the concentrations at which these peptides induce significant hemolysis of human red blood cells, as follows: ranatuerin-1Ga: 100 µM ranatuerin-2G: 35 µM temporin-1Gb: 16 µM (There are duplicate annotations in the document, both labeled as 16 µM.) temporin-1Gd: 4 µM The above values were determined experimentally as follows: Peptides at concentrations ranging from 1 to 100 µM were incubated with washed human red blood cells (2 × 10⁶ cells) in Dulbecco’s phosphate-buffered saline (pH 7.4) at 37°C for 1 hour. After centrifugation (900×g, 10 minutes), the absorbance of the supernatant was measured at 451 nm to determine the peptide concentration corresponding to significant hemolysis. Furthermore, studies have shown that peptides from the temporin family (such as temporin-1Gb and temporin-1Gd) can induce hemolysis even at low concentrations, whereas ranatuerin-1Ga requires the highest concentration (100 µM) to elicit significant hemolysis, highlighting the differences in hemolytic activity among peptides from different families.|||ranatuerin-1Ga: 100 uMranatuerin-2G: 35 uMtemporin-1Gb: 16 uMtemporin-1Gd: 4 uM|||Human RBCs (HL50 = 12.5 uM)|||EC₅₀=100 uM" Regul Pept 2000; 90: 53-60. PubMed.|||2000 Jun 30;90(1-3):53-60. doi: 10.1016/s0167-0115(00)00107-5.|||10828493, 29842923||Refer PubMed ID: 29842923|||Regul Pept. 2000 Jun 30;90(1-3):53-60. 14 FPDB00940 AP00955|||AP00955|||GNU6|||DRAMP21138|||GNU6|||AP00955|||DRAMP21138 RIIRPIIQIIKQKIR Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Gram+ B. subtilis, activity value is MIC = 2 ug/ml||Anti-E. faecalis, activity value is MIC = 2 ug/ml||Anti-E. faecium VRE, activity value is MIC = 2 ug/ml||Anti-M. luteus, activity value is MIC = 2 ug/ml||Anti-S. aureus or MRSA, activity value is MIC = 2 ug/ml||Anti-E. coli, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa, activity value is MIC = 2 ug/ml||Anti-S. typhimurium, activity value is MIC = 4 ug/ml||Anti-C. albicans, activity value is MIC = 2 ug/ml||Anti-C. neoformans, activity value is MIC = 2 ug/ml||Anti-and S. cerevisiae, activity value is MIC = 4 ug/ml||Anti-Bacillus subtilis KCTC 3038, activity value is MIC = 2 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 2 ug/ml||Anti-Micrococcus luteus ATCC 10240, activity value is MIC = 2 ug/ml||Anti-Micrococcus luteus ATCC 10240, activity value is MIC = 8 ug/ml||Anti-Micrococcus luteus ATCC 10240, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 8 ug/ml||Anti-Escherichia coli ATCC 27325, activity value is MIC = 4 ug/ml||Anti-Escherichia coli ATCC 27325, activity value is MIC = 32 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 2 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 32 ug/ml||Anti-Salmonella typhimurium KCTC 2370, activity value is MIC = 4 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 2 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 16 ug/ml||Anti-Cryptococcus neoformans ATCC 34881, activity value is MIC = 2 ug/ml||Anti-Cryptococcus neoformans ATCC 34881, activity value is MIC = 16 ug/ml||Anti-Saccharomyces cerevisiae ATCC 44774, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 2||Anti-Enterococcus faecium, activity value is MIC = 2 ug/ml||Anti-Enterococcus gallinarum, activity value is MIC = 2 ug/ml||Anti-Enterococcus casseliflavus, activity value is MIC = 2 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 2 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 2 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 2 ug/ml||Anti-Escherichia coli, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 2 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 4 ug/ml||Anti-Candida albicans, activity value is MIC = 2 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 2 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC = 4 ug/ml||Antibacterial||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 4 ug/ml||Anti-##Fungi : Candida albicans, activity value is MIC = 2 ug/ml De novo designed, man-made sequences|||De novo designed, man-made sequences|||Synthetic construct|||Synthetic construct|||De novo designed, man-made sequences|||Synthetic construct Helix||Alpha helix "GNU5, GNU6, GNU7: In hemolysis experiments, these three peptides showed no hemolytic activity against human red blood cells (RBCs) at all tested concentrations (up to 128 µg/ml), and were non-toxic to human keratinocytes (HaCaT) and skin fibroblasts (BJ). Magainin 2: Similar to GNU5, GNU6, and GNU7, it showed no cytotoxicity to human cells at the tested concentrations. - Buforin IIb: At a concentration of 128 µg/ml, it caused 14.5% hemolysis of red blood cells; at 64 µg/ml, it killed 63.9% of HaCaT keratinocytes and 31.8% of BJ skin fibroblasts, showing certain hemolytic activity and cytotoxicity.|||Buforin IIb: At a concentration of 128 µg/ml, the hemolysis rate was 14.5%. GNU5, GNU6, and GNU7: No hemolytic activity was observed on red blood cells.|||Human erythrocytes (- at NA|||- Test subject: human red blood cells, incubation conditions at 37°C for 30 minutes, detection wavelength 567 nm; negative control (PBS only) showed 0% hemolysis, positive control (0.2% Triton X-100) showed 100% hemolysis. - Key results: - Designed peptides GNU5, GNU6, GNU7: At concentrations up to 128 µg/ml, hemolysis rate was 0%, showing no hemolytic activity and excellent safety. - Control peptides: - Magainin 2: Similar to the designed peptides, no hemolysis at 128 µg/ml. - Buforin IIb: At 128 µg/ml, hemolysis rate was 14.5%, indicating some hemolytic activity. - Key correlation: The designed peptides eliminate hemolysis by disrupting the hydrophobic surface of the α-helix (inserting lysine residues) while maintaining high hydrophobicity (46%) and strong antibacterial activity (MIC 1–4 µg/ml, effective against MRSA and VRE), and exhibit no cytotoxicity to human keratinocytes (HaCaT) or fibroblasts (BJ).|||Human erythrocytes (- at NA|||[Ref.23946320] 0% hemolysis at 140 ug/ml against human red blood cells" "J Antimicrob Chemother . 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. Epub 2013 Aug 14.|||2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. Epub 2013 Aug 14.|||23946320|||J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322.||Ref.23946320|||23946320|||J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. PubMed.|||J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322.||Ref.23946320|||J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. PubMed." 15 FPDB00948 AP01321|||AP01321|||Ostricacin-2|||DRAMP03286|||AP01321 APGNKAECEREKGYCGFLKCSFPFVVSGKCSRFFFCCKNIW Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Anti-S. aureus 1056 MRSA, activity value is MIC = 1.25 ug/ml||Anti-E. coli O157:H7, activity value is MIC = 0.96 ug/ml||Anti-and C. albicans 3153A, activity value is MIC = 6.2 ug/ml||Antibacterial||Anti-Staphylococcus aureus 1056-MRSA, activity value is MIC = 1.25 ug/ml||Anti-Escherichia coli O157:H7, activity value is MIC = 0.96 ug/ml||Anti-Candida albicans 3153A, activity value is MIC = 6.2 ug/ml Struthio camelus|||Struthio camelus|||Struthio camelus [Ostrich]|||Struthio camelus (Ostrich)|||Struthio camelus Bridge "Table Antimicrobial Peptide Hemolytic Activity (RCH, %) Test Concentration OdA1 14.2±5.6 50 µg/ml OdB1 None 50 µg/ml OdC1 None 50 µg/ml OdD1 None 50 µg/ml Ode1 None 50 µg/ml OdF1 None 50 µg/ml OdG1 None 50 µg/ml OdH1 None 50 µg/ml OdI1 None 50 µg/ml OdJ1 None 50 µg/ml OdK1 None 50 µg/ml OdL1 22.4±7.2 50 µg/ml Odd1 7.7±3.5 50 µg/ml OdN1 None 50 µg/ml Odo1 None 50 µg/ml OdP1a None 50 µg/ml OdP2a None 50 µg/ml Odd1 23.6±3.7 50 µg/ml OdR1 None 50 µg/ml Ods1 None 50 µg/ml OdT1 None 50 µg/ml OdU1 5.2±2.3 50 µg/ml OdV1 None 50 µg/ml OdW1 None 50 µg/ml Nigrocin-OG2 18.1±7.7 50 µg/ml Nigrocin-OG4 22.3±3.1 50 µg/ml Nigrocin-OG5 14.0±5.2 50 µg/ml Nigrocin-OG13 None 50 µg/ml Nigrocin-OG20 None 50 µg/ml Nigrocin-OG21 17.0±2.8 50 µg/ml The experiment used the Triton X-100 treated group as the 100% hemolysis control. At this concentration, different antimicrobial peptides exhibited varying hemolytic activities. Some peptides showed no detectable hemolytic activity (NA), while others had a certain degree of hemolysis.|||The hemolytic activity (RCH) of certain peptides (such as odorranain-A1, etc.) was mostly NA (not detected) or low at the tested concentration (50 µg/mL); specific values can be found in the “RCH” column of Table III. For example, the hemolysis rates of odorranain-B1, -C1, and others did not exceed the statistically significant threshold.|||Hemolysis assay is a standard biological method to investigate cytotoxic effects of an agent on red blood cells. For brevinin-Eu and cyanophlyctin b, only 1.9% and 0.7% hemolytic activity was observed, respectively, at 500 lg/ mL in comparison with Triton-X-100 as positive control with 100% hemolysis. Low hemolytic activity makes them" "Mol Cell Proteomics . 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||16459058|||Int J Antimicrob Agents. 2006 Mar;27(3):229-235.|||Int J Antimicrob Agents. 2006 Mar;27(3):229-35. Pub-Med.|||Int J Antimicrob Agents. 2006 Mar;27(3):229-35. Pub-Med." 41 FPDB00952 AP01380|||DRAMP02740|||Beta-defensin 1|||AP01380 " YDLSKNCRLRGGICYIGKCPRRFFRSGSCSRGNVCCLRFG" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-HS): Escherichia coli ML35p, activity value is MIC = 0.65||Anti-HS): Listeria monocytogenes EGD, activity value is MIC = 0.65||Anti-Methicillin-resistant Staphylococcus aureus ATCC 33591, activity value is MIC = 5.6||Anti->20 uM). Yeast: Candida albicans, activity value is MIC = 5.2||Antibacterial the European pond turtle, Emys orbicularis|||the European pond turtle, Emys orbicularis|||Emys orbicularis (European pond turtle)|||Emys orbicularis [European pond turtle]|||the European pond turtle, Emys orbicularis Bridge "Melittin, a bee venom hemolytic peptide, can cause complete lysis of red blood cells at a concentration of 10 µM, and partial lysis can still be observed at concentrations as low as 0.625 µM. Pilosulin 1 can cause complete lysis of red blood cells at a concentration of 40 µM, and partial lysis can still be observed at concentrations as low as 1.25 µM. Whole jack jumper ant venom can cause complete lysis of red blood cells at the highest concentration of 200 µg/ml, and partial lysis can still be observed at concentrations as low as 25 µg/ml." Proteomics. 2009 Mar;9(5):1364-73|||Proteomics. 2009 Mar;9(5):1364-1373.||Ref.19253295|||19253295|||Proteomics. 2009 Mar;9(5):1364-73 40 FPDB00953 AP01444|||DRAMP01758 " FLSAITSILGKFF" Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Anti-Antinacterial activity was not reported due to a limited amount of material. We filled up this gap by using a synthetic peptide. Active against S. aureus USA300, activity value is MIC = 6.3 uM||Anti-S. epidermidis 1457, activity value is MIC = 6.3 uM||Anti-B. subtilis 168, activity value is MIC = 12.5 uM||Anti-C. albicans, activity value is MIC = 25 uM||Anti-D. glabrata, activity value is MIC = 25 uM||Antimicrobial||Antibacterial Rana septentrionalis , North America|||Rana septentrionalis , North America|||Rana septentrionalis (mink frog) N/A "The values related to hemolysis mentioned in this document are the half-maximal hemolytic concentrations (HC_{50}), which is the peptide concentration that produces 50% hemolytic effect. The specific data are as follows: - Brevinin-1SPa: HC_{50} = 7 μM - Brevinin-1SPb: HC_{50} = 25 μM - Brevinin-1SPd: HC_{50} = 8 μM - Temporin-1SPb: HC_{50} = 60 μM - Brevinin-2-related peptide: HC_{50} = 70 μM These values were measured through hemolysis experiments and reflect the hemolytic activity of different antimicrobial peptides on human red blood cells. The lower the value, the stronger the hemolytic effect.|||The document mentions the following hemolytic-related values: brevinin-1SPa: half-maximal hemolytic concentration (HC₅₀) on human red blood cells is 7 µM. brevinin-1SPb: HC₅₀ on human red blood cells is 25 µM. brevinin-1SPd: HC₅₀ on human red blood cells is 8 µM. temporin-1SPb: HC₅₀ on human red blood cells is 60 µM. brevinin-2 related peptides: HC₅₀ on human red blood cells is 70 µM." "Comparative Study Comp Biochem Physiol C Toxicol Pharmacol . 2004 Oct;139(1-3):31-8. doi: 10.1016/j.cca.2004.08.019.|||2004 Oct;139(1-3):31-8. doi: 10.1016/j.cca.2004.08.019.|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-8. PubMed|||Comp. Biochem. Physiol. C 2004; 139: 31-38." 13 FPDB00955 AP01497|||AP01497|||Temporin-CPb|||Temporin-CPb|||AP01497|||DRAMP01786 " FLPIVGRLISGIL" Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Anti-Staphylococcus aureus USA300, activity value is MIC = 12.5 uM||Anti-Staphylococcus epidermidis 1457, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis 168, activity value is MIC = 25||Anti-Candida albicans ATCC 10231, activity value is MIC = 50 uM||Anti-C. tropicalis ATCC 13803, activity value is MIC = 6.2||Antibacterial||Antimicrobial the New World frog Lithobates capito, North America|||the New World frog Lithobates capito, North America|||Rana capito [Florida gopher frog]|||Rana capito [Florida gopher frog]|||the New World frog Lithobates capito, North America|||Lithobates capito (New World frog) N/A "The values related to hemolysis mentioned in this document are the half-maximal hemolytic concentrations (HC_{50}), which is the peptide concentration that produces 50% hemolytic effect. The specific data are as follows: - Brevinin-1SPa: HC_{50} = 7 μM - Brevinin-1SPb: HC_{50} = 25 μM - Brevinin-1SPd: HC_{50} = 8 μM - Temporin-1SPb: HC_{50} = 60 μM - Brevinin-2-related peptide: HC_{50} = 70 μM These values were measured through hemolysis experiments and reflect the hemolytic activity of different antimicrobial peptides on human red blood cells. The lower the value, the stronger the hemolytic effect.|||LC50=220 uM|||Human RBCs (HL50 = >100 uM)|||Human RBCs (HL50 = >100 uM)" "Peptides . 2009 Oct;30(10):1775-81. doi: 10.1016/j.peptides.2009.07.011. Epub 2009 Jul 25.|||Peptides . 2009 Oct;30(10):1775-81. doi: 10.1016/j.peptides.2009.07.011. Epub 2009 Jul 25.|||19635516, 29842923||Refer PubMed ID: 29842923|||19635516, 29842923|||Peptides. 2009 Oct;30(10):1775-81. Pub-Med.|||Regul Pept 2007; 138: 87-93.|||Peptides. 2009 Oct;30(10):1775-81. Pub-Med." 13 FPDB00962 AP01622|||AP01622|||CPF-B1|||CPF-B1|||AP01622 " GLGSLLGKAFKIGLKTVGKMMGGAPREQ" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Escherichia coli, activity value is MIC = 5 uM||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-Candida albicans, activity value is MIC = 25 uM Marsabit Clawed Frog, Xenopus borealis, Africa|||Marsabit Clawed Frog, Xenopus borealis, Africa|||Xenopus borealis [Kenyan clawed frog]|||Xenopus borealis [Kenyan clawed frog]|||Marsabit Clawed Frog, Xenopus borealis, Africa N/A Human erythrocytes ( LC50 > 200 uM )|||LC50 > 200 uM Comp Biochem Physiol C Toxicol Pharmacol. 2010 Nov;152(4):467-72|||Comp Biochem Physiol C Toxicol Pharmacol. 2010 Nov;152(4):467-72|||20656059|||20656059|||Comp Biochem Physiol C Toxicol Pharmacol. 2010 Nov;152(4):467-72 28 FPDB00963 AP01644|||AP01644|||Brevinin-2-RN1|||DRAMP02036|||Brevinin-2-RN1|||AP01644 " GAFGNFLKGVAKKAGLKILSIAQCKLSGTC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibacterial||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 3.1 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 12.5 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa PA01, activity value is MIC = 12.5 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 25 ug/ml Rana nigrovittata,, or Sylvirana nigrovittata , Asia|||Rana nigrovittata,, or Sylvirana nigrovittata , Asia|||Rana nigrovittata [Black-striped frog]|||Rana nigrovittata|||Rana nigrovittata [Black-striped frog]|||Rana nigrovittata,, or Sylvirana nigrovittata , Asia N/A "The hemolysis-related values mentioned in this document are the hemolysis rates of rabbit red blood cells caused by two antimicrobial peptides, with the specific data as follows: - Brevinin-2-RN1: At a concentration of 100 µg/ml, the hemolysis rate of rabbit red blood cells is 17%. - Brevinin-2-RN2: At a concentration of 100 µg/ml, the hemolysis rate of rabbit red blood cells is 21%. These data were measured through hemolysis experiments, reflecting the hemolytic activity of the two antimicrobial peptides on rabbit red blood cells, both exhibiting moderate hemolytic effects.|||In the Journal of Peptide Science 2011, brevinin-2-RN1 and brevinin-2-RN2, isolated from the skin secretions of the black-banded frog (Rana nigrovittata), showed moderate hemolytic activity against rabbit red blood cells, inducing 17% and 21% hemolysis of rabbit red blood cells at a concentration of 100 μg/ml, respectively.|||[Ref.21171145] It has 17% hemolysis at 100 ug/ml against rabbit red blood cell|||Some antimicrobial peptides can act on eukaryotic membrane and exhibit hemolytic activities because of their hydrophobic structures [3]. In our experiments, rabbit red blood cells were used to check for hemolytic capabilities of brevinin-2-RN1 and -RN2. They showed moderate hemolytic activity. At the concentration of 100 ug/ml, brevinin-2-RN1 and -RN2 could induce 17 and 21% rabbit red blood cell hemolysis, respectively." "J Pept Sci . 2011 Jan;17(1):68-72. doi: 10.1002/psc.1309. Epub 2010 Oct 25.|||J Pept Sci . 2011 Jan;17(1):68-72. doi: 10.1002/psc.1309. Epub 2010 Oct 25.|||21171145|||J Pept Sci. 2011 Jan;17(1):68-72.|||21171145|||J Pept Sci. 2011 Jan;17(1):68-72. doi: 10.1002/psc.1309. Epub 2010 Oct 25. PubMed.|||J Pept Sci. 2011 Jan;17(1):68-72. doi: 10.1002/psc.1309. Epub 2010 Oct 25. PubMed." 30 FPDB00964 AP01645|||AP01645|||Brevinin-2-RN2|||DRAMP02037|||Brevinin-2-RN2|||AP01645 GAFGNFLKGVAKKAGLKILSIAQCKLFGTC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibacterial||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 6.25 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 12.5 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa PA01, activity value is MIC = 12.5 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 12.5 ug/ml Rana nigrovittata,, or Sylvirana nigrovittata , Asia|||Rana nigrovittata,, or Sylvirana nigrovittata , Asia|||Rana nigrovittata [Black-striped frog]|||Rana nigrovittata|||Rana nigrovittata [Black-striped frog]|||Rana nigrovittata,, or Sylvirana nigrovittata , Asia N/A "The hemolysis-related values mentioned in this document are the hemolysis rates of rabbit red blood cells caused by two antimicrobial peptides, with the specific data as follows: - Brevinin-2-RN1: At a concentration of 100 µg/ml, the hemolysis rate of rabbit red blood cells is 17%. - Brevinin-2-RN2: At a concentration of 100 µg/ml, the hemolysis rate of rabbit red blood cells is 21%. These data were measured through hemolysis experiments, reflecting the hemolytic activity of the two antimicrobial peptides on rabbit red blood cells, both exhibiting moderate hemolytic effects.|||In the Journal of Peptide Science 2011, brevinin-2-RN1 and brevinin-2-RN2, isolated from the skin secretions of the black-banded frog (Rana nigrovittata), showed moderate hemolytic activity against rabbit red blood cells, inducing 17% and 21% hemolysis of rabbit red blood cells at a concentration of 100 μg/ml, respectively.|||Some antimicrobial peptides can act on eukaryotic membrane and exhibit hemolytic activities because of their hydrophobic structures [3]. In our experiments, rabbit red blood cells were used to check for hemolytic capabilities of brevinin-2-RN1 and -RN2. They showed moderate hemolytic activity. At the concentration of 100 ug/ml, brevinin-2-RN1 and -RN2 could induce 17 and 22% rabbit red blood cell hemolysis, respectively.|||21% at 100 uM" "J Pept Sci . 2011 Jan;17(1):68-72. doi: 10.1002/psc.1309. Epub 2010 Oct 25.|||J Pept Sci . 2011 Jan;17(1):68-72. doi: 10.1002/psc.1309. Epub 2010 Oct 25.|||21171145|||J Pept Sci. 2011 Jan;17(1):68-72|||21171145|||J Pept Sci. 2011 Jan;17(1):68-72. doi: 10.1002/psc.1309. Epub 2010 Oct 25 PubMed.|||J Pept Sci. 2011 Jan;17(1):68-72. doi: 10.1002/psc.1309. Epub 2010 Oct 25 PubMed." 30 FPDB00965 AP01663|||DRAMP02660|||Neutrophil defensin 4|||AP01663|||DRAMP02660 RRTCRCRFGRCFRRESYSGSCNINGRIFSLCCR Anti-Gram+||Antifungal||Anti-MRSA||Antimicrobial||Antibacterial||Anti-Gram- leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus monkey)|||Macaca mulatta [Rhesus macaque]|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus monkey) Bridge N/A "Infect Immun . 1999 Nov;67(11):6139-44. doi: 10.1128/IAI.67.11.6139-6144.1999.|||Infect Immun. 1999 Nov;67(11):6139-6144.|||10531277|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed.|||Infect Immun. 1999 Nov;67(11):6139-6144.|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed." 33 FPDB00966 AP01670|||DRAMP03198|||AP01670 ACYCRIPACFAGERRYGTCFYLGRVWAFCC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-In low salt conditions: Gram-negative bacterium: E. coli ML35p, activity value is MIC = 2.4 uM||Anti-Listeria monocytogenes EGD, activity value is MIC = 2.2 uM||Anti-methicillin-resistant S. aureus ATCC 33591, activity value is MIC = 3.5 uM||Anti-L. monocytogenes EGD, activity value is MIC = 1.8 uM||Anti-S. aureus ATCC 33591, activity value is MIC > 50 uM||Anti-Candida albicans 820, activity value is MIC > 50 uM||Anti-the Gram- bacterium E. coli ML35p, activity value is MIC = 2.4 uM||Anti-the Gram+ bacteria L. monocytogenes EGD, activity value is MIC = 2.2 uM||Anti-and the fungus C. albicans 820, activity value is MIC = 3.9 uM blood leukocytes, Papio hamadryas|||Papio hamadryas (Hamadryas baboon)|||blood leukocytes, Papio hamadryas Bridge N/A Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604|||Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604.|||Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604 30 FPDB00968 AP01704|||DRAMP01483|||AP01704|||DRAMP01483 RIFSKIGGKAIKNLILKGIKNIGKEVGMDVIRTGIDVAGCKIKGEC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Staphylococcus aureus, activity value is MIC = 3.1 uM||Anti-Staphylococcus aureus, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis, activity value is MIC = 12.5 uM skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae (Japanese Endangered frog)|||skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae (Japanese Endangered frog) N/A N/A "Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||Peptides. 2011 Apr;32(4):670-676.|||21193000|||Peptides. 2011 Apr;32(4):670-6. Pub-Med.|||Gram-negative bacterium: Escherichia coli (MC=3.1 uM); Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 uM), Staphylococcus aureus (MRSA) (MIC=12.5 uM), Bacillus subtilis (MIC=12.5 uM). Yeast: Candida albicans (MIC=50 uM).|||Peptides. 2011 Apr;32(4):670-6. Pub-Med." 46 FPDB00969 AP01705|||AP01705|||Esculentin-2ISa|||DRAMP01484|||Esculentin-2ISa|||AP01705|||DRAMP01484 " GIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 3.1 uM||Anti-Staphylococcus aureus, activity value is MIC = 25 uM||Anti-Bacillus subtilis, activity value is MIC = 6.3 uM||Anti-E. coli ATCC 8739, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 3.1 uM||Anti-ATCC 43300, activity value is MIC = 25 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 6.3 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 100 uM skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae [Ishikawa's frog]|||Odorrana ishikawae (Japanese Endangered frog)|||Odorrana ishikawae [Ishikawa's frog]|||skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae (Japanese Endangered frog) N/A N/A "Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||21193000|||Peptides. 2011 Apr;32(4):670-676.|||21193000|||Peptides. 2011 Apr;32(4):670-6. Pub-Med.|||Gram-negative bacterium: Escherichia coli (MC=12.5 uM); Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 uM), Staphylococcus aureus (MRSA) (MIC=25 uM), Bacillus subtilis (MIC=6.3 uM). Yeast: Candida albicans (MIC=100 uM).|||Peptides. 2011 Apr;32(4):670-6. Pub-Med." 37 FPDB00970 AP01706|||AP01706|||Palustrin-2ISa|||DRAMP01237|||Palustrin-2ISa|||AP01706|||DRAMP01237 " GFMDTAKNVAKNVAVTLLDKLKCKITGGC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Escherichia coli, activity value is MIC = 100 uM||Anti-Staphylococcus aureus, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 100 uM||Anti-Candida albicans, activity value is MIC = 100 uM||Anti-Staphylococcus aureus, activity value is MIC = 100 uM||Anti-Bacillus subtilis, activity value is MIC = 12.5 uM||Anti-E. coli, activity value is MIC = 100 uM||Anti-S. aureus, activity value is MIC = 25 uM||Anti-MRSA, activity value is MIC = 100 uM||Anti-B. subtilis, activity value is MIC = 12.5 uM skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae|||Odorrana ishikawae|||skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae (Ishikawa's frog) N/A N/A "Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||21911019|||Peptides. 2011 Apr;32(4):670-676.|||21193000|||21911019|||Peptides. 2011 Apr;32(4):670-6. Pub-Med.|||Peptides. 2011 Apr;32(4):670-6. Pub-Med." 29 FPDB00971 AP01707|||AP01707|||Brevinin-2ISa SLLDTFKNLAVNAAKSAGVSVLNALSCKISRTC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli, activity value is MIC = 50 uM||Anti-S. aureus, activity value is MIC = 12.5 uM||Anti-MRSA, activity value is MIC = 100 uM||Anti-B. subtilis, activity value is MIC = 12.5 uM||Anti-and C.albicans, activity value is MIC > 100 uM||Antibacterial skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae [Ishikawa's frog] N/A N/A "Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||21193000|||Peptides. 2011 Apr;32(4):670-6. Pub-Med." 33 FPDB00972 AP01710|||AP01710|||Nigrocin-2ISa|||DRAMP01414|||Nigrocin-2ISa|||AP01710|||DRAMP01414 " GIFSTVFKAGKGIVCGLTGLC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 3.1 uM||Anti-MRSA, activity value is MIC = 12.5 uM||Anti-B. subtilis, activity value is MIC = 12.5 uM||Anti-and C. albicans, activity value is MIC = 50 uM||Anti-E. coli ATCC 8739, activity value is MIC = 25 uM||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 3.1 uM||Anti-ATCC 43300, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 12.5 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 50 uM||Anti-Escherichia coli, activity value is MIC = 25 uM||Anti-Staphylococcus aureus, activity value is MIC = 3.1 uM||Anti-Staphylococcus aureus, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis, activity value is MIC = 12.5 uM skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae [Ishikawa's frog]|||Odorrana ishikawae (Ishikawa's frog)|||skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae (Ishikawa's frog) N/A N/A "Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||21193000|||Peptides. 2011 Apr;32(4):670-676.|||21193000|||Peptides. 2011 Apr;32(4):670-6. Pub-Med.|||Gram-negative bacterium: Escherichia coli (MIC=25 uM); Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 uM), Staphylococcus aureus (MRSA) (MIC=12.5 uM), Bacillus subtilis (MIC=12.5 uM). Yeast: Candida albicans (MIC=50 uM).|||Peptides. 2011 Apr;32(4):670-6. Pub-Med." 21 FPDB00973 AP01711|||AP01711|||Nigrocin-2ISb|||DRAMP01415|||Nigrocin-2ISb|||AP01711|||DRAMP01415 GILGTVFKAGKGIVCGLTGLC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli, activity value is MIC = 50 uM||Anti-S. aureus, activity value is MIC = 3.1 uM||Anti-MRSA, activity value is MIC = 12.5 uM||Anti-B. subtilis, activity value is MIC = 12.5 uM||Anti-and C. albicans, activity value is MIC = 50 uM||Anti-E. coli ATCC 8739, activity value is MIC = 50 uM||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 3.1 uM||Anti-ATCC 43300, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 12.5 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 50 uM||Anti-Escherichia coli, activity value is MIC = 50 uM||Anti-Staphylococcus aureus, activity value is MIC = 3.1 uM||Anti-Staphylococcus aureus, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis, activity value is MIC = 12.5 uM skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae [Ishikawa's frog]|||Odorrana ishikawae (Ishikawa's frog)|||skin, the endangered frog, Odorrana ishikawae, Japan, Asia|||Odorrana ishikawae (Ishikawa's frog) N/A N/A "Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||Peptides . 2011 Apr;32(4):670-6. doi: 10.1016/j.peptides.2010.12.013. Epub 2010 Dec 28.|||21193000|||Peptides. 2011 Apr;32(4):670-676.|||21193000|||Peptides. 2011 Apr;32(4):670-6. Pub-Med.|||Gram-negative bacterium: Escherichia coli (MIC=50 uM); Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 uM), Staphylococcus aureus (MRSA) (MIC=12.5 uM), Bacillus subtilis (MIC=12.5 uM). Yeast: Candida albicans (MIC=50 uM).|||Peptides. 2011 Apr;32(4):670-6. Pub-Med." 21 FPDB00977 AP01782|||DRAMP01416|||AP01782|||DRAMP01416 GILSTVFKAGKGIVCGLSGLC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli, activity value is MIC = 50 uM||Anti-S. aureus or MRSA, activity value is MIC = 3.1||Anti-B. subtilis, activity value is MIC = 12.5 uM||Anti-and C. albicans, activity value is MIC = 100 uM||Anti-Escherichia coli, activity value is MIC = 50 uM||Anti-Staphylococcus aureus, activity value is MIC = 3 uM Odorrana ishikawae , Japan, Asia|||Odorrana ishikawae (Ishikawa's frog)|||Odorrana ishikawae , Japan, Asia|||Odorrana ishikawae (Ishikawa's frog) N/A In the study of antimicrobial peptides from the skin of Kaloula leopard frogs, human red blood cells were used as the test subject. The half-maximal hemolytic concentration (LC₅₀) of Esculentin-2CHa was 150 µM, Ranatuerin-2CHa was 135 µM, Ranatuerin-2CHb was 120 µM, Brevinin-1CHa and Brevinin-1CHb both had an LC₅₀ of 5 µM, while no specific LC₅₀ values were detected for Brevinin-1CHc and Palustrin-2CHa. "Biochem Biophys Res Commun . 2011 Sep 9;412(4):673-7. doi: 10.1016/j.bbrc.2011.08.023. Epub 2011 Aug 16.|||Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-677.|||21867685|||Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-7. PubMed.|||Gram-negative bacterium: Escherichia coli (MIC=50 uM); Gram-positive bacterium: Staphylococcus aureus (MIC=3 uM). Yeast: Candida albicans (MIC=100 uM).|||Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-7. PubMed." 21 FPDB00978 AP01783 " FLPGVLRLVTKVGPAVVCAITRNC" Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Anti-E.coli, activity value is MIC > 100 uM||Anti-S. aureus or MRSA, activity value is MIC = 3.1 uM||Anti-B. subtilis, activity value is MIC = 6.3 uM||Anti-and C. albicans, activity value is MIC = 50 uM Odorrana ishikawae , Japan, Asia N/A N/A "Biochem Biophys Res Commun . 2011 Sep 9;412(4):673-7. doi: 10.1016/j.bbrc.2011.08.023. Epub 2011 Aug 16.|||Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-7. PubMed." 24 FPDB00979 AP01791|||AP01791|||Antimicrobial peptide ctriporin|||Antimicrobial peptide ctriporin|||AP01791 FLWGLIPGAISAVTSLIKK Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus AB94004 MRSA, activity value is MIC = 5||Anti-B. thuringiensis AB92037, activity value is MIC = 10 ug/ml||Anti-B. subtilis AB91021, activity value is MIC = 10 ug/ml||Anti-M. luteus AB93113, activity value is MIC = 5 ug/ml||Anti-and C. albicans AY93025, activity value is MIC = 20 ug/ml||Anti-penicillin-resistant S. epidermidis at 10 ug/ml. active against E. faecium ATCC29212, activity value is MIC = 64 ug/ml||Anti-A. baumannii ATCC19606, activity value is MIC = 16 ug/ml||Anti-Bacillus thuringiensis AB92037, activity value is MIC = 10 ug/ml||Anti-Bacillus subtilis AB91021, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus AB94004, activity value is MIC = 5 ug/ml||Anti-Micrococcus luteus AB93113, activity value is MIC = 5 ug/ml||Anti-Candida albicans AY93025, activity value is MIC = 20 ug/ml||Anti-Escherichia coli AB94012, activity value is MIC > 100 ug/ml||Anti-Pseudomonas aeruginosa AB93066, activity value is MIC > 100 ug/ml venom, Chaerilus tricostatus, Asia|||venom, Chaerilus tricostatus|||Chaerilus tricostatus [Scorpion] Helix N/A "Antimicrob Agents Chemother . 2011 Nov;55(11):5220-9. doi: 10.1128/AAC.00369-11. Epub 2011 Aug 29.|||Antimicrob Agents Chemother . 2011 Nov;55(11):5220-9. doi: 10.1128/AAC.00369-11. Epub 2011 Aug 29.|||21876042|||21876042|||Antimicrob Agents Chemother . 2011 Nov;55(11):5220-9. doi: 10.1128/AAC.00369-11. Epub 2011 Aug 29.|||Antimicrob Agents Chemother. 2011 Nov;55(11):5220-9. PubMed." 19 FPDB00981 AP01898|||AP01898|||Cathelicidin-AL|||DRAMP01319|||AP01898|||DRAMP01319 RRSRRGRGGGRRGGSGGRGGRGGGGRSGAGSSIAGVGSRGGGGGRHYA Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus ATCC25923, activity value is MIC = 6.25 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 6.25 ug/ml||Anti-B. subtilis, activity value is MIC = 100 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 50 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 25||Anti-P. aeruginosa PA01, activity value is MIC = 12.5 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 6.25 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 100 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 25 ug/ml||Anti-Psecdomonas aeruginosa PA01, activity value is MIC = 12.5 ug/ml||Anti-Psecdomonas aeruginosa ATCC27853, activity value is MIC = 6.25 ug/ml skin secretions, frog, Amolops loloensis, China, Asia|||Amolops loloensis [Rufous-spotted torrent frog]|||Amolops loloensis|||skin secretions, frog, Amolops loloensis, China, Asia|||Amolops loloensis Rich "The provided document reports the hemolytic assay results for cathelicidin-AL: even at concentrations as high as 400 µg/mL, this peptide exhibits negligible hemolytic activity toward human erythrocytes, which is significantly higher than its minimum inhibitory concentration (MIC), indicating a pronounced selectivity between microbial and mammalian cells.|||skin secretions, frog, Amolops loloensis, China, Asia|||In the study of the brown-spotted torrent frog amphibian antimicrobial peptide cathelicidin-AL, cathelicidin-AL exhibited negligible hemolytic activity against human red blood cells, and even at concentrations as high as 400 μg/ml (far exceeding its minimum inhibitory concentration against bacteria), no significant red blood cell lysis was observed.|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 78).|||at 400 ug/ml, little hemo.lytic" "Amino Acids . 2012 Aug;43(2):677-85. doi: 10.1007/s00726-011-1116-7. Epub 2011 Oct 19.|||Amino Acids. 2012 Aug;43(2):677-85. doi: 10.1007/s00726-011-1116-7. Epub 2011 Oct 19.|||22009138|||Amino Acids. 2012 Aug;43(2):677-685|||22009138|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||Amino Acids. 2012 Aug;43(2):677-85. PubMed." 48 FPDB00983 AP01940|||AP01940|||Nigroain-C2|||DRAMP01539|||DRAMP01543|||Nigroain-C2|||AP01940|||DRAMP01539 " FKTWKRPPFQTSCWGIIKE" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus ATCC25923 or ATCC43300 MRSA, activity value is MIC = 27.5||Anti-P. aeruginosa PA01 or ATCC27853, activity value is MIC = 55 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 13.75 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 27.5 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 55 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 110 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 13.75 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 110 ug/ml||Anti-P. aeruginosa PA01, activity value is MIC = 55 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 55 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 55 ug/ml||Anti-Pseudomonas aeruginosa PA01, activity value is MIC = 55 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 55 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 18.75 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 75 ug/ml skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata [Black-striped frog]|||Rana nigrovittata (Black-striped frog)|||skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata (Black-striped frog) N/A "nigroain-K2: At a concentration of 100 ug/ml, the hemolysis rate is 85.52±3.26%. - temporin-RN1: At a concentration of 100 ug/ml, the hemolysis rate is 95.7±4.12%. - temporin-RN3: At a concentration of 50 ug/ml, the hemolysis rate is 87.2±3.67%. - gaegurin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 46.13±1.49%. - nigroain-K1: At a concentration of 50 ug/ml, the hemolysis rate is 22.49±4.80%. - gaegurin-RN4: At a concentration of 50 ug/ml, the hemolysis rate is 18.64±0.25%. - gaegurin-RN5: At a concentration of 50 ug/ml, the hemolysis rate is 16.16±3.22%. - rugosin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 6.69±1.51%. - nigroain-E1: At a concentration of 50 ug/ml, the hemolysis rate is 7.62±1.60%. Note: ""ND"" indicates no hemolytic activity detected at concentrations up to 100 ug/ml.|||skin secretions, Rana nigrovittata , China, Asia|||In the study of black-banded frog skin antimicrobial peptides, rabbit red blood cells were used as the test subject. Most antimicrobial peptides exhibited weak hemolysis at a concentration of 100 µg/ml, while Nigroain-K2 and Temporin-RN1 showed a hemolysis rate of 85%–95% at a concentration of 50 µg/ml. Temporin-RN3 had a hemolysis rate of 87.2% at 100 µg/ml. Nigroain-K1, due to the lack of a C-terminal disulfide bond, showed significantly reduced hemolytic activity, with a hemolysis rate of only 22.49±4.80% at 100 µg/ml.|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K1 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity." "Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||19778602|||Genomics. 2010 Jan;95(1):66-71.|||Genomics. 2010 Jan;95(1):66-71.||Ref.19778602|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22|||Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=27.5 ug/ml), S. aureus ATCC43300 (MIC=55 ug/ml), Bacillus subtilis (MIC=110 ug/ml); Gram-negative bacteria: Escherichia coli ML-35P (MIC=110 ug/ml), Pseudomonas aeruginosa PA01 (MIC=55 ug/ml), Pseudomonas aeruginosa ATCC27853 (MIC=55 ug/ml). Yeast: Candida albicans ATCC2002 (MIC=13.75 ug/ml).|||Genomics. 2010 Jan;95(1):66-71. PubMed." 19 FPDB00984 AP01944|||AP01944|||Nigroain-K2|||DRAMP01547|||Nigroain-K2|||AP01944|||DRAMP01547 " SLWETIKNAGKGFILNILDKIRCKVAGGCKT" Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anti-S. aureus ATCC25923, activity value is MIC = 11.25 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 9.38 ug/ml||Anti-B. subtilis, activity value is MIC = 9.38 ug/ml||Antibacterial||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 11.25 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 9.38 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 9.38 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa PA01, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 25 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 15 ug/ml skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata [Black-striped frog]|||Rana nigrovittata (Black-striped frog)|||Rana nigrovittata [Black-striped frog]|||skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata (Black-striped frog) N/A "nigroain-K2: At a concentration of 100 ug/ml, the hemolysis rate is 85.52±3.26%. - temporin-RN1: At a concentration of 100 ug/ml, the hemolysis rate is 95.7±4.12%. - temporin-RN3: At a concentration of 50 ug/ml, the hemolysis rate is 87.2±3.67%. - gaegurin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 46.13±1.49%. - nigroain-K1: At a concentration of 50 ug/ml, the hemolysis rate is 22.49±4.80%. - gaegurin-RN4: At a concentration of 50 ug/ml, the hemolysis rate is 18.64±0.25%. - gaegurin-RN5: At a concentration of 50 ug/ml, the hemolysis rate is 16.16±3.22%. - rugosin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 6.69±1.51%. - nigroain-E1: At a concentration of 50 ug/ml, the hemolysis rate is 7.62±1.60%. Note: ""ND"" indicates no hemolytic activity detected at concentrations up to 100 ug/ml.|||skin secretions, Rana nigrovittata , China, Asia||85.52%(50 ug/ml )|||In the study of black-banded frog skin antimicrobial peptides, rabbit red blood cells were used as the test subject. Most antimicrobial peptides exhibited weak hemolysis at a concentration of 100 µg/ml, while Nigroain-K2 and Temporin-RN1 showed a hemolysis rate of 85%–95% at a concentration of 50 µg/ml. Temporin-RN3 had a hemolysis rate of 87.2% at 100 µg/ml. Nigroain-K1, due to the lack of a C-terminal disulfide bond, showed significantly reduced hemolytic activity, with a hemolysis rate of only 22.49±4.80% at 100 µg/ml.|||[Ref:19778602]85.52 ± 3.26% hemolytic activity at 50 ug/ml against rabbit red cells|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K4 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity.|||[Ref:19778602]85.52 ± 3.26% hemolytic activity at 50 ug/ml against rabbit red cells|||85% hemolysis at 100 ug/ml" "Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||19778602|||Genomics. 2010 Jan;95(1):66-71.||Ref.19778602|||19778602||Ref.19778602|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 23.|||[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=11.25 ug/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 ug/ml), Bacillus subtilis (MIC=9.38 ug/ml); Gram-positive bacteria: Escherichia coli ML-35P (MIC=25 ug/ml), Pseudomonas aeruginosa PA01 (MIC=25 ug/ml), Pseudomonas aeruginosa ATCC27853 (MIC=25 ug/ml); Yeast: Candida albicans ATCC2002 (MIC=15 ug/ml)|||Genomics. 2010 Jan;95(1):66-71. PubMed." 31 FPDB00985 AP01945|||AP01945|||Gaegurin-RN1|||DRAMP02288|||Gaegurin-RN1|||AP01945 FIGPVLKIAAGILPTAICKIFKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus ATCC25923, activity value is MIC = 2.34 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 9.38 ug/ml||Anti-B. subtilis, activity value is MIC = 4.69 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 18.75 ug/ml||Antibacterial||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 2.34 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 9.38 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 4.69 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 18.75 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 4.69 ug/ml skin secretions, Rana nigrovittata, China, Asia|||Rana nigrovittata [Black-striped frog]|||Rana nigrovittata|||Rana nigrovittata [Black-striped frog]|||skin secretions, Rana nigrovittata, China, Asia N/A "nigroain-K2: At a concentration of 100 ug/ml, the hemolysis rate is 85.52±3.26%. - temporin-RN1: At a concentration of 100 ug/ml, the hemolysis rate is 95.7±4.12%. - temporin-RN3: At a concentration of 50 ug/ml, the hemolysis rate is 87.2±3.67%. - gaegurin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 46.13±1.49%. - nigroain-K1: At a concentration of 50 ug/ml, the hemolysis rate is 22.49±4.80%. - gaegurin-RN4: At a concentration of 50 ug/ml, the hemolysis rate is 18.64±0.25%. - gaegurin-RN5: At a concentration of 50 ug/ml, the hemolysis rate is 16.16±3.22%. - rugosin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 6.69±1.51%. - nigroain-E1: At a concentration of 50 ug/ml, the hemolysis rate is 7.62±1.60%. Note: ""ND"" indicates no hemolytic activity detected at concentrations up to 100 ug/ml.|||skin secretions, Rana nigrovittata, China, Asia||0.4613|||Staphylococcus aureus ATCC25923 ( MIC = 2.34 ug/ml ), Staphylococcus aureus ATCC43300 ( MIC = 9.38 ug/ml ), Bacillus subtilis ( MIC = 4.69 ug/ml ), Candida albicans ATCC2002 ( MIC = 4.69 ug/ml ), Escherichia coli ML-35P ( MIC = 18.75 ug/ml )|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K5 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity.|||50% hemolysis at 100 uM." "Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||19778602|||Genomics. 2010 Jan;95(1):66-71.||Ref.19778602|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 24.|||Genomics. 2010 Jan;95(1):66-71. PubMed." 24 FPDB00986 AP01946|||AP01946|||Gaegurin-RN4|||DRAMP02289|||Gaegurin-RN4|||AP01946 FVGPVLKIAAGILPTAICKIYKKC Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus ATCC25923, activity value is MIC = 1.17 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 9.38 ug/ml||Anti-B. subtilis, activity value is MIC = 2.34 ug/ml||Antibacterial||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 1.17 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 9.38 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 2.34 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 2.34 ug/ml skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata [Black-striped frog]|||Rana nigrovittata|||Rana nigrovittata [Black-striped frog]|||skin secretions, Rana nigrovittata , China, Asia N/A "nigroain-K2: At a concentration of 100 ug/ml, the hemolysis rate is 85.52±3.26%. - temporin-RN1: At a concentration of 100 ug/ml, the hemolysis rate is 95.7±4.12%. - temporin-RN3: At a concentration of 50 ug/ml, the hemolysis rate is 87.2±3.67%. - gaegurin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 46.13±1.49%. - nigroain-K1: At a concentration of 50 ug/ml, the hemolysis rate is 22.49±4.80%. - gaegurin-RN4: At a concentration of 50 ug/ml, the hemolysis rate is 18.64±0.25%. - gaegurin-RN5: At a concentration of 50 ug/ml, the hemolysis rate is 16.16±3.22%. - rugosin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 6.69±1.51%. - nigroain-E1: At a concentration of 50 ug/ml, the hemolysis rate is 7.62±1.60%. Note: ""ND"" indicates no hemolytic activity detected at concentrations up to 100 ug/ml.|||skin secretions, Rana nigrovittata , China, Asia||0.1616|||Staphylococcus aureus ATCC25923 ( MIC = 1.17 ug/ml ), Staphylococcus aureus ATCC43300 ( MIC = 9.38 ug/ml ), Bacillus subtilis ( MIC = 2.34 ug/ml ), Candida albicans ATCC2002 ( MIC = 2.34 ug/ml )|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K6 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity." "Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||19778602|||Genomics. 2010 Jan;95(1):66-71.||Ref.19778602|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 25.|||Genomics. 2010 Jan;95(1):66-71. PubMed." 24 FPDB00987 AP01947|||AP01947|||Gaegurin-RN5|||DRAMP02290|||Gaegurin-RN5|||AP01947 " FLGPIIKIATGILPTAICKFLKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus ATCC25923, activity value is MIC = 3.75 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 62.5 ug/ml||Anti-B. subtilis, activity value is MIC = 4.69 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 37.5 ug/ml||Antibacterial||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 3.75 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 62.5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 4.69 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 4.69 ug/ml skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata [Black-striped frog]|||Rana nigrovittata|||Rana nigrovittata [Black-striped frog]|||skin secretions, Rana nigrovittata , China, Asia N/A "nigroain-K2: At a concentration of 100 ug/ml, the hemolysis rate is 85.52±3.26%. - temporin-RN1: At a concentration of 100 ug/ml, the hemolysis rate is 95.7±4.12%. - temporin-RN3: At a concentration of 50 ug/ml, the hemolysis rate is 87.2±3.67%. - gaegurin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 46.13±1.49%. - nigroain-K1: At a concentration of 50 ug/ml, the hemolysis rate is 22.49±4.80%. - gaegurin-RN4: At a concentration of 50 ug/ml, the hemolysis rate is 18.64±0.25%. - gaegurin-RN5: At a concentration of 50 ug/ml, the hemolysis rate is 16.16±3.22%. - rugosin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 6.69±1.51%. - nigroain-E1: At a concentration of 50 ug/ml, the hemolysis rate is 7.62±1.60%. Note: ""ND"" indicates no hemolytic activity detected at concentrations up to 100 ug/ml.|||skin secretions, Rana nigrovittata , China, Asia|||Staphylococcus aureus ATCC25923 ( MIC = 3.75 ug/ml ), Staphylococcus aureus ATCC43300( MIC = 62.5 ug/ml ), Bacillus subtilis ( MIC = 4.69 ug/ml ), Candida albicans ATCC2002 ( MIC = 4.69 ug/ml ), Escherichia coli ML-35P ( MIC = 37.5 ug/ml)|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K7 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity." "Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||19778602|||Genomics. 2010 Jan;95(1):66-71.||Ref.19778602|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 26.|||Genomics. 2010 Jan;95(1):66-71. PubMed." 24 FPDB00988 AP01950|||AP01950|||Rugosin-RN5|||DRAMP01526|||Rugosin-RN5|||AP01950|||DRAMP01526 SIRDKIKTIAIDLAKSAGTGVLKTLICKLNKSC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus ATCC25923, activity value is MIC = 15 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 12.5 ug/ml||Anti-B. subtilis, activity value is MIC = 18.75 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 25 ug/ml||Antibacterial||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 15 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 12.5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 18.75 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 25 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 18.75 ug/ml skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata [Black-striped frog]|||Rana nigrovittata|||Rana nigrovittata [Black-striped frog]|||skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata N/A "nigroain-K2: At a concentration of 100 ug/ml, the hemolysis rate is 85.52±3.26%. - temporin-RN1: At a concentration of 100 ug/ml, the hemolysis rate is 95.7±4.12%. - temporin-RN3: At a concentration of 50 ug/ml, the hemolysis rate is 87.2±3.67%. - gaegurin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 46.13±1.49%. - nigroain-K1: At a concentration of 50 ug/ml, the hemolysis rate is 22.49±4.80%. - gaegurin-RN4: At a concentration of 50 ug/ml, the hemolysis rate is 18.64±0.25%. - gaegurin-RN5: At a concentration of 50 ug/ml, the hemolysis rate is 16.16±3.22%. - rugosin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 6.69±1.51%. - nigroain-E1: At a concentration of 50 ug/ml, the hemolysis rate is 7.62±1.60%. Note: ""ND"" indicates no hemolytic activity detected at concentrations up to 100 ug/ml.|||skin secretions, Rana nigrovittata , China, Asia|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K10 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity." "Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||19778602|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 29.|||Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=15 ug/ml), Staphylococcus aureus ATCC43300 (MRSA) (MIC=12.5 ug/ml), Bacillus subtilis (MIC=18.75 ug/ml); Gram-negative bacterium: Escherichia coli ML-35P (MIC=25 ug/ml). Yeast: Candida albicans ATCC2002 (MIC=18.75 ug/ml).|||Genomics. 2010 Jan;95(1):66-71. PubMed." 33 FPDB00989 AP01952|||DRAMP01808|||Temporin-RN3|||AP01952|||DRAMP01808 FFPLLFGALSSHLPKLF Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anti-S. aureus ATCC25923, activity value is MIC = 3.75 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 7.5 ug/ml||Anti-B. subtilis, activity value is MIC = 7.5 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 15 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 3.75 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 3.75 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3.75 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 3.75 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 3.75 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 7.5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 7.5 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 3.75 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 15 ug/ml||Anti-Pseudomonas aeruginosa PA01, activity value is MIC = 3.75 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 3.75 ug/ml skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata|||skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata N/A "nigroain-K2: At a concentration of 100 ug/ml, the hemolysis rate is 85.52±3.26%. - temporin-RN1: At a concentration of 100 ug/ml, the hemolysis rate is 95.7±4.12%. - temporin-RN3: At a concentration of 50 ug/ml, the hemolysis rate is 87.2±3.67%. - gaegurin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 46.13±1.49%. - nigroain-K1: At a concentration of 50 ug/ml, the hemolysis rate is 22.49±4.80%. - gaegurin-RN4: At a concentration of 50 ug/ml, the hemolysis rate is 18.64±0.25%. - gaegurin-RN5: At a concentration of 50 ug/ml, the hemolysis rate is 16.16±3.22%. - rugosin-RN1: At a concentration of 50 ug/ml, the hemolysis rate is 6.69±1.51%. - nigroain-E1: At a concentration of 50 ug/ml, the hemolysis rate is 7.62±1.60%. Note: ""ND"" indicates no hemolytic activity detected at concentrations up to 100 ug/ml.|||skin secretions, Rana nigrovittata , China, Asia||87.2%(50 ug/ml )|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K12 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity." "Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||Genomics. 2010 Jan;95(1):66-71.|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 31.|||Genomics. 2010 Jan;95(1):66-71. PubMed." 17 FPDB00996 AP02044|||AP02044|||Brevinin-1JDa|||DRAMP02073|||AP02044 " FLPAVIRVAANVLPTVFCAISKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli, activity value is MIC = 50 uM||Anti-S. aureus MRSA, activity value is MIC = 6||Anti-and C. albicans, activity value is MIC = 50 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||Anti-S. aureus, activity value is MIC = 32 ug/ml||Anti-Escherichia coli, activity value is MIC = 128 ug/ml||Anti-Candida albicans, activity value is MIC = 128 ug/ml skin, Odorrana jingdongensis , China, Asia|||Odorrana jingdongensis [Jingdong frog]|||Odorrana andersonii (Chinese odorous frog)|||skin, Odorrana jingdongensis , China, Asia N/A "The hemolytic values of the antimicrobial peptides (AMPs) mentioned in the document at a concentration of 128 µg/ml are as follows: - Brevinin-2JD: 11.7 ± 3.2% - Brevinin-1JDa: 79.2 ± 6.8% - Nigrocin-2JDa: 80.3 ± 5.5% - Nigrocin-2JDb: 88.4 ± 4.2% Note: The hemolytic values of Esculentin-2JDa, Esculentin-2JDb, and Brevinin-1JDb were not determined (ND) or not mentioned.|||skin, Odorrana jingdongensis , China, Asia||HC₅₀ = 3.5 uM。|||Rabbit erythrocytes 79.2±6.8% lysis (128 ug/ml)|||The abilities of the intact peptides isolated from the skin of O. jingdongensis to inhibit the growth of S. aureus,MRSA, E. coli,ESBLand C. albicans, and the hemolytic activities of the peptides (128 ug/ml) on rabbit red blood cells were shown in Table 3. The values of two pairs of intact peptides were given as the mixed components due to not being separated by commonly used reverse HPLC methods using C18orC4column(data notshown) [10,45,46],suchas Brevinin-1JDa and Brevinin-1JD or Esculentin-2JDa and Esculentin-2JDb. The four near homogeneity AMPs and two pairs of mixed AMPs showed vary and moderate activities (8–128 ug/ml) against all gram-negative and gram-positive bacteria with their resistant strains tested. The anti-fungi activities and hemolytic activities of mixture of Esculentin-2JDa and Esculentin-2JDa were under detectable even at the highest concentration (128 ug/ml) tested, while the activities of the others, except Brevinin-1JDc, excluded due to the very low abundance, is obvious (64– 128 ug/ml to C. albicans and 11.7±3.2 to 88.4±4.2% to rabbit blood red cells).|||79.2% hemolysis at 50 uM." "J Proteomics . 2012 Oct 22;75(18):5807-21. doi: 10.1016/j.jprot.2012.08.004. Epub 2012 Aug 16.|||J Proteomics. 2012 Oct 22;75(18):5807-21. doi: 10.1016/j.jprot.2012.08.004. Epub 2012 Aug 16.|||22917879|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22917879|||J Proteomics . 2012 Oct 22;75(18):5807-21. doi: 10.1016/j.jprot.2012.08.004. Epub 2012 Aug 16.|||J Proteomics. 2012 Oct 22;75(18):5807-21. Pub-Med." 24 FPDB00998 AP02046|||AP02046|||Nigrocin-2JDa|||DRAMP01438|||Nigrocin-2JDa|||AP02046|||DRAMP01438 " GIFGKILGAGKKVLCGLSGLC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli, activity value is MIC = 16 uM||Anti-S. aureus, activity value is MIC = 16 uM||Anti-and C. albicans, activity value is MIC = 63 uM||Anti-Staphylococcus aureus, activity value is MIC = 32 ug/ml||Anti-CIB 85462, activity value is MIC = 16 ug/ml||Anti-Escherichia coli, activity value is MIC = 32 ug/ml||Anti-CIB 84492, activity value is MIC = 32 ug/ml||Anti-Candida albicans, activity value is MIC = 128 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 16 uM||Anti-Staphylococcus aureus CIB 85462, activity value is MIC = 8 uM||Anti-Escherichia coli ATCC 25992, activity value is MIC = 16 uM||Anti-Escherichia coli CIB 84492, activity value is MIC = 16 uM||Anti-Candida albicans, activity value is MIC = 63 uM||Hemolytic skin, Odorrana jingdongensis , China, Asia|||Odorrana jingdongensis [Jingdong frog]|||Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)|||skin, Odorrana jingdongensis , China, Asia|||Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) N/A "The hemolytic values of the antimicrobial peptides (AMPs) mentioned in the document at a concentration of 128 µg/ml are as follows: - Brevinin-2JD: 11.7 ± 3.2% - Brevinin-1JDa: 79.2 ± 6.8% - Nigrocin-2JDa: 80.3 ± 5.5% - Nigrocin-2JDb: 88.4 ± 4.2% Note: The hemolytic values of Esculentin-2JDa, Esculentin-2JDb, and Brevinin-1JDb were not determined (ND) or not mentioned.|||skin, Odorrana jingdongensis , China, Asia||HC₅₀ = 34.5 uM。|||[Ref:22917879] It has 80.3 ± 5.5% hemolytic activity at 128 ug/ml against rabbit red blood cells|||Rabbit erythrocytes 80.3±5.5% hemolysis (128 ug/ml)|||The abilities of the intact peptides isolated from the skin of O. jingdongensis to inhibit the growth of S. aureus,MRSA, E. coli,ESBLand C. albicans, and the hemolytic activities of the peptides (128 ug/ml) on rabbit red blood cells were shown in Table 3. The values of two pairs of intact peptides were given as the mixed components due to not being separated by commonly used reverse HPLC methods using C18orC4column(data notshown) [10,45,46],suchas Brevinin-1JDa and Brevinin-1JD or Esculentin-2JDa and Esculentin-2JDb. The four near homogeneity AMPs and two pairs of mixed AMPs showed vary and moderate activities (8–128 ug/ml) against all gram-negative and gram-positive bacteria with their resistant strains tested. The anti-fungi activities and hemolytic activities of mixture of Esculentin-2JDa and Esculentin-2JDa were under detectable even at the highest concentration (128 ug/ml) tested, while the activities of the others, except Brevinin-1JDc, excluded due to the very low abundance, is obvious (64– 128 ug/ml to C. albicans and 11.7±3.2 to 88.4±4.3% to rabbit blood red cells).|||[Ref:22917879] It has 80.3 ± 5.5% hemolytic activity at 128 ug/ml against rabbit red blood cells|||80.3% hemolysis at 63 uM." "J Proteomics . 2012 Oct 22;75(18):5807-21. doi: 10.1016/j.jprot.2012.08.004. Epub 2012 Aug 16.|||J Proteomics. 2012 Oct 22;75(18):5807-21. doi: 10.1016/j.jprot.2012.08.004. Epub 2012 Aug 16.|||22917879|||J Proteomics. 2012 Oct 22;75(18):5807-5821.||Ref.22917879|||22917879||Ref.22917879|||22917879|||J Proteomics . 2012 Oct 22;75(18):5807-21. doi: 10.1016/j.jprot.2012.08.004. Epub 2012 Aug 16.|||[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=16 uM), Staphylococcus aureus CIB 85462 (MIC=8 uM); Gram-negative bacteria: Escherichia coli ATCC 25992 (MIC=16 uM), Escherichia coli CIB 84492 (MIC=16 uM); Yeast: Candida albicans (MIC=63 uM).|||J Proteomics. 2012 Oct 22;75(18):5807-21. Pub-Med." 21 FPDB00999 AP02047|||AP02047|||Nigrocin-2JDb|||DRAMP01439|||Nigrocin-2JDb|||AP02047|||DRAMP01439 " GIFGKILGVGKKVLCGLSGMC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli, activity value is MIC = 15 uM||Anti-S. aureus, activity value is MIC = 8 uM||Anti-MRSA, activity value is MIC = 8 uM||Anti-and C. albicans, activity value is MIC = 31 uM||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||Anti-CIB 85462, activity value is MIC = 16 ug/ml||Anti-Escherichia coli, activity value is MIC = 32 ug/ml||Anti-CIB 84492, activity value is MIC = 32 ug/ml||Anti-Candida albicans, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 15 uM||Anti-Staphylococcus aureus CIB 85462, activity value is MIC = 15 uM||Anti-Escherichia coli ATCC 25992, activity value is MIC = 8 uM||Anti-Escherichia coli CIB 84492, activity value is MIC = 8 uM||Anti-Candida albicans, activity value is MIC = 31 uM skin, Odorrana jingdongensis , China, Asia|||Odorrana jingdongensis [Jingdong frog]|||Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)|||skin, Odorrana jingdongensis , China, Asia|||Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) N/A "The hemolytic values of the antimicrobial peptides (AMPs) mentioned in the document at a concentration of 128 µg/ml are as follows: - Brevinin-2JD: 11.7 ± 3.2% - Brevinin-1JDa: 79.2 ± 6.8% - Nigrocin-2JDa: 80.3 ± 5.5% - Nigrocin-2JDb: 88.4 ± 4.2% Note: The hemolytic values of Esculentin-2JDa, Esculentin-2JDb, and Brevinin-1JDb were not determined (ND) or not mentioned.|||skin, Odorrana jingdongensis , China, Asia||HC₅₀ = 46.2 uM。|||[Ref:22917879] It has 88.4 ± 4.2% hemolytic activity at 128 ug/ml against rabbit red blood cells|||Rabbit erythrocytes 88.4±4.2% hemolysis (128 ug/ml)|||The abilities of the intact peptides isolated from the skin of O. jingdongensis to inhibit the growth of S. aureus,MRSA, E. coli,ESBLand C. albicans, and the hemolytic activities of the peptides (128 ug/ml) on rabbit red blood cells were shown in Table 3. The values of two pairs of intact peptides were given as the mixed components due to not being separated by commonly used reverse HPLC methods using C18orC4column(data notshown) [10,45,46],suchas Brevinin-1JDa and Brevinin-1JD or Esculentin-2JDa and Esculentin-2JDb. The four near homogeneity AMPs and two pairs of mixed AMPs showed vary and moderate activities (8–128 ug/ml) against all gram-negative and gram-positive bacteria with their resistant strains tested. The anti-fungi activities and hemolytic activities of mixture of Esculentin-2JDa and Esculentin-2JDa were under detectable even at the highest concentration (128 ug/ml) tested, while the activities of the others, except Brevinin-1JDc, excluded due to the very low abundance, is obvious (64– 128 ug/ml to C. albicans and 11.7±3.2 to 88.4±4.4% to rabbit blood red cells).|||[Ref:22917879] It has 88.4 ± 4.2% hemolytic activity at 128 ug/ml against rabbit red blood cells" "J Proteomics . 2012 Oct 22;75(18):5807-21. doi: 10.1016/j.jprot.2012.08.004. Epub 2012 Aug 16.|||J Proteomics. 2012 Oct 22;75(18):5807-21. doi: 10.1016/j.jprot.2012.08.004. Epub 2012 Aug 16.|||22917879|||J Proteomics. 2012 Oct 22;75(18):5807-5821.||Ref.22917879|||22917879||Ref.22917879|||22917879|||J Proteomics . 2012 Oct 22;75(18):5807-21. doi: 10.1016/j.jprot.2012.08.004. Epub 2012 Aug 16.|||[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15 uM), Staphylococcus aureus CIB 85462 (MIC=15 uM); Gram-negative bacteria: Escherichia coli ATCC 25992 (MIC=8 uM), Escherichia coli CIB 84492 (MIC=8 uM); Yeast: Candida albicans (MIC=31 uM).|||J Proteomics. 2012 Oct 22;75(18):5807-21. Pub-Med." 21 FPDB01000 AP02048|||Beta-defensin 1TB precursor|||AP02048 " DHYLCVKNEGICLYSSCPSYTKIEGTCYGGKAKCCK" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus ATCC 25923, activity value is MIC = 4.5 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 3 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC = 18 ug/ml||Anti-C. albicans ATCC 20032, activity value is MIC = 24 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 24 ug/ml||Anti-P. aeruginosa PA01, activity value is MIC = 12 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 12 ug/ml tree shrew, Tupaia belangeri, Asia|||Tupaia belangeri [Common tree shrew]|||tree shrew, Tupaia belangeri, Asia Bridge "The hemolytic values of β-defensin 1TB in the document are as follows: - At a concentration of 100 µg/ml, the hemolysis rate is 2.3% for human red blood cells and 1.6% for rabbit red blood cells. - At a concentration of 200 µg/ml, the hemolysis rate is 5.2% for human red blood cells and 3.9% for rabbit red blood cells.|||tree shrew, Tupaia belangeri, Asia||At a concentration of 100 μM, the hemolysis rate is < 10%.|||Some antimicrobial peptides have been found to exert hemolytic activities against red cells (Hazlett and Wu, 2011). In our experi- ments, human and rabbit red blood cells were used to check for he- molytic capabilities of β-defensin 1TB. β-defensin 1TB showed little hemolytic activity. At the concentration of 100 ug/ml, it induced 2.3% and 1.6% human and rabbit red blood cell hemolysis, respective- ly. At the concentration of 200 ug/ml, the corresponding hemolysis rate was 5.2% and 3.9%, respectively." "Gene . 2012 Nov 10;509(2):258-62. doi: 10.1016/j.gene.2012.08.013. Epub 2012 Aug 24.|||Gene. 2012 Nov 10;509(2):258-62. doi: 10.1016/j.gene.2012.08.013.|||22939868|||Gene . 2012 Nov 10;509(2):258-62. doi: 10.1016/j.gene.2012.08.013. Epub 2012 Aug 24.|||Gene. 2012 Nov 10;509(2):258-62. doi: 10.1016/j.gene.2012.08.013. Pub-Med." 36 FPDB01001 AP02049 " FFHHIFRGIVHVGKTIHKLVTGT" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. faecalis, activity value is MIC = 5||Anti-L. monocytogenes, activity value is MIC = 2.5||Anti-M. luteus, activity value is MIC = 10||Anti-S. epidermidis, activity value is MIC = 5||Anti-S. saprophiticus, activity value is MIC = 5||Anti-S. agalactiae, activity value is MIC = 1.25||Anti-S. bovis, activity value is MIC = 1.25||Anti-S. equisimilis, activity value is MIC = 2.5||Anti-S. mitis, activity value is MIC = 1.25||Anti-S. pneumoniae, activity value is MIC = 1.25||Anti-S. pyogenes, activity value is MIC = 1.25||Anti-S. iniae, activity value is MIC = 1.25||Anti-negative V. cholera, activity value is MIC = 2.5||Anti-E. coli, activity value is MIC = 5||Anti-E. cloacae, activity value is MIC = 110||Anti-E. aerogenes, activity value is MIC = 10||Anti-K. pneumoniae, activity value is MIC = 2.5||Anti-K. oxytoca, activity value is MIC = 5||Anti-M. catarrhalis, activity value is MIC = 2.5||Anti-P. aeruginosa, activity value is MIC = 5||Anti-S. choleraesuis, activity value is MIC = 10||Anti-S. typhimurium, activity value is MIC = 10||Anti-S-arizonae, activity value is MIC > 20 uM||Anti-S. flexneri, activity value is MIC = 2.5||Anti-S. sonnei, activity value is MIC = 5||Anti-Y. enterocolitica, activity value is MIC = 2.5||Anti-filamentous fungi N. crassa, activity value is MIC = 1.56||Anti-A. fumigatus, activity value is MIC = 50||Anti-F. oxysporum, activity value is MIC = 0.78||Anti-F. culmorum, activity value is MIC = 0.39||activity value is MIC = 10||Anti-C. glabrata, activity value is MIC = 10||Anti-C. lusitania, activity value is MIC = 10||Anti-and C. tropicalis, activity value is MIC = 10 skin/gill, Morone saxatilis Helix "The hemolytic values of the synthesized amidated white bass moronecidin (wb-moronecidin) on human and sheep red blood cells are as follows in the document: Table Concentration (µM) | Human RBC Hemolysis (%) | Sheep RBC Hemolysis (%) 0.31 | 0 | 0 0.63 | 0 | 0 1.25 | 0 | 0 2.5 | 0 | 0 5 | 19 | Not explicitly mentioned 10 | 55 | Not explicitly mentioned 20 | 100 | 58 80 | 100 | 100 Note: The data in the table represent the average of two independent experiments. No hemolytic activity was observed at low concentrations (≤2.5 µM), and hemolytic activity increased in a dose-dependent manner with increasing concentration.|||skin/gill, Morone saxatilis||HC₅₀ ≈ 3 uM。" "J Biol Chem . 2002 Feb 15;277(7):5030-9. doi: 10.1074/jbc.M109173200. Epub 2001 Dec 5.|||J Biol Chem. 2002 Feb 15;277(7):5030-9. doi: 10.1074/jbc.M109173200. Epub 2001 Dec 5.|||J Biol Chem. 2002 Feb 15;277(7):5030-9. Pub-Med." 23 FPDB01004 AP02106|||AP02106|||Temporin-LK1|||Temporin-LK1|||AP02106 " FFPLLFGALSSMMPKLF" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus ATCC2592, activity value is MIC = 2.5 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 2.5 ug/ml||Anti-B. subtilis, activity value is MIC = 15 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 30 ug/ml||Anti-P. aeruginosa PA01, activity value is MIC = 2.5 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 2.5 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 5 ug/ml||Anti-S. aureus ATCC 2592, activity value is MIC = 2.5 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 2.5 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 5 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 2.5 ug/ml the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia|||Limnonectes kuhlii [Kuhl's wart frog] N/A "The hemolytic values of five antimicrobial peptides on rabbit red blood cells at a concentration of 100 µg/ml are as follows: - temporin-LK1: 10.2% - gaegurin-LK1: 5.6% - gaegurin-LK2: 6.2% - rugosin-LK1: 3.8% - rugosin-LK2: 6.1% These values indicate that their hemolytic activity is relatively low, with rugosin-LK1 showing the weakest hemolytic activity.|||the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia||HC₅₀ = 8.2 uM。|||Rabbit RBC (10.2% hemolysis at 100 ug/ml)|||Rabbit RBC (10.2% hemolysis at 100 ug/ml)|||Some antimicrobial peptides exhibit hemolytic activities by interacting with eukaryote membranes [3]. In our experi- ments, rabbit red blood cells were used to test hemolytic capabilities of these antimicrobial peptides. Most of them showed a little hemolytic activity. At the concentration of 100 lg/ml, temporin-LK1, gaegurin-LK1, gaegurin-LK2, rugosin-LK1, and rugosin-LK2 induced 10.2, 5.6, 6.2, 3.8, and 6.1 % rabbit red blood cell hemolysis, respectively.|||At 100 ug/ml, temporin-LK1 induced 10.2% hemolysis: less hemo.lytic." "Mol Biol Rep . 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||Mol Biol Rep. 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||23054029|||23054029|||Mol Biol Rep . 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||Mol Biol Rep. 2013 Feb;40(2):1097-102. Pub-Med." 17 FPDB01005 AP02107|||AP02107|||Gaegurin-LK1|||Gaegurin-LK1|||AP02107 FIGPVLKMATSILPTAICKGFKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus ATCC2592, activity value is MIC = 5 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 10 ug/ml||Anti-B. subtilis, activity value is MIC = 20 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 50 ug/ml||Anti-P. aeruginosa PA01, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 5 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 10 ug/ml||Antibacterial||Anti-S. aureus ATCC 2592, activity value is MIC = 5 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 10 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 5 ug/ml the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia|||Limnonectes kuhlii [Kuhl's wart frog]|||Limnonectes kuhlii [Kuhl's wart frog]|||the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia N/A "The hemolytic values of five antimicrobial peptides on rabbit red blood cells at a concentration of 100 µg/ml are as follows: - temporin-LK1: 10.2% - gaegurin-LK1: 5.6% - gaegurin-LK2: 6.2% - rugosin-LK1: 3.8% - rugosin-LK2: 6.1% These values indicate that their hemolytic activity is relatively low, with rugosin-LK1 showing the weakest hemolytic activity.|||the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia||HC₅₀ = 6.5 uM。|||Rabbit RBC (5.6% hemolysis at 100 ug/ml)|||Rabbit RBC (5.6% hemolysis at 100 ug/ml)|||Some antimicrobial peptides exhibit hemolytic activities by interacting with eukaryote membranes [3]. In our experi- ments, rabbit red blood cells were used to test hemolytic capabilities of these antimicrobial peptides. Most of them showed a little hemolytic activity. At the concentration of 100 lg/ml, temporin-LK1, gaegurin-LK1, gaegurin-LK2, rugosin-LK1, and rugosin-LK2 induced 10.2, 5.6, 6.2, 3.8, and 6.2 % rabbit red blood cell hemolysis, respectively.|||At 100 ug/ml, gaegurin-LK1 induced 5.6% hemolysis: less hemo.lytic." "Mol Biol Rep . 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||Mol Biol Rep. 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||23054029|||23054029|||Mol Biol Rep . 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 11.|||Mol Biol Rep. 2013 Feb;40(2):1097-102. Pub-Med." 24 FPDB01006 AP02108|||AP02108|||Gaegurin-LK2|||Gaegurin-LK2|||AP02108 " FLGPIIKMATGILPTAICKGLKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus ATCC2592, activity value is MIC = 2.5 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 2.5 ug/ml||Anti-B. subtilis, activity value is MIC = 20 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 50 ug/ml||Anti-P. aeruginosa PA01, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 5 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 5 ug/ml||Antibacterial||Anti-S. aureus ATCC 2592, activity value is MIC = 2.5 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 2.5 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 5 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 5 ug/ml the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia|||Limnonectes kuhlii [Kuhl's wart frog]|||Limnonectes kuhlii [Kuhl's wart frog]|||the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia N/A "The hemolytic values of five antimicrobial peptides on rabbit red blood cells at a concentration of 100 µg/ml are as follows: - temporin-LK1: 10.2% - gaegurin-LK1: 5.6% - gaegurin-LK2: 6.2% - rugosin-LK1: 3.8% - rugosin-LK2: 6.1% These values indicate that their hemolytic activity is relatively low, with rugosin-LK1 showing the weakest hemolytic activity.|||the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia||HC₅₀ = 7.1 uM。|||Rabbit RBC (6.2% hemolysis at 100 ug/ml)|||Rabbit RBC (6.2% hemolysis at 100 ug/ml)|||Some antimicrobial peptides exhibit hemolytic activities by interacting with eukaryote membranes [3]. In our experi- ments, rabbit red blood cells were used to test hemolytic capabilities of these antimicrobial peptides. Most of them showed a little hemolytic activity. At the concentration of 100 lg/ml, temporin-LK1, gaegurin-LK1, gaegurin-LK2, rugosin-LK1, and rugosin-LK2 induced 10.2, 5.6, 6.2, 3.8, and 6.3 % rabbit red blood cell hemolysis, respectively.|||At 100 ug/ml, gaegurin-LK2 induced 6.2% hemolysis: less hemo.lytic." "Mol Biol Rep . 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||Mol Biol Rep. 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||23054029|||23054029|||Mol Biol Rep . 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 12.|||Mol Biol Rep. 2013 Feb;40(2):1097-102. Pub-Med." 24 FPDB01007 AP02109|||AP02109|||Rugosin-LK1|||Rugosin-LK1|||AP02109 " SIRDKIKTMAIDLAKSAGTGVLKTLICKLDKSC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti->: Active against S. aureus ATCC2592, activity value is MIC = 10 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 15 ug/ml||Anti-B. subtilis, activity value is MIC = 40 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa PA01, activity value is MIC = 5 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 5 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 10 ug/ml||Antibacterial||Anti-S. aureus ATCC 2592, activity value is MIC = 10 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 15 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 5 ug/ml the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia|||Limnonectes kuhlii [Kuhl's wart frog]|||Limnonectes kuhlii [Kuhl's wart frog]|||the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia N/A "The hemolytic values of five antimicrobial peptides on rabbit red blood cells at a concentration of 100 µg/ml are as follows: - temporin-LK1: 10.2% - gaegurin-LK1: 5.6% - gaegurin-LK2: 6.2% - rugosin-LK1: 3.8% - rugosin-LK2: 6.1% These values indicate that their hemolytic activity is relatively low, with rugosin-LK1 showing the weakest hemolytic activity.|||the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia||At a concentration of 100 μM, the hemolysis rate is < 10%.|||Rabbit RBC (3.8% hemolysis at 100 ug/ml)|||Rabbit RBC (3.8% hemolysis at 100 ug/ml)|||Some antimicrobial peptides exhibit hemolytic activities by interacting with eukaryote membranes [3]. In our experi- ments, rabbit red blood cells were used to test hemolytic capabilities of these antimicrobial peptides. Most of them showed a little hemolytic activity. At the concentration of 100 lg/ml, temporin-LK1, gaegurin-LK1, gaegurin-LK2, rugosin-LK1, and rugosin-LK2 induced 10.2, 5.6, 6.2, 3.8, and 6.4 % rabbit red blood cell hemolysis, respectively.|||At 100 ug/ml, rugosin-LK1 induced 3.8%, less hemo.lytic." "Mol Biol Rep . 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||Mol Biol Rep. 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||23054029|||23054029|||Mol Biol Rep . 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 13.|||Mol Biol Rep. 2013 Feb;40(2):1097-102. Pub-Med." 33 FPDB01008 AP02110|||AP02110|||Rugosin-LK2|||Rugosin-LK2|||AP02110 " SIRDKGKTIAIDLAKSAGTGVLKTLMCKLDKSC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti->: Active against S. aureus ATCC2592, activity value is MIC = 10 ug/ml||Anti-S. aureus ATCC43300, activity value is MIC = 10 ug/ml||Anti-B. subtilis, activity value is MIC = 30 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa PA01, activity value is MIC = 2.5 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 2.5 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 10 ug/ml||Antibacterial||Anti-S. aureus ATCC 2592, activity value is MIC = 10 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 10 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 2.5 ug/ml the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia|||Limnonectes kuhlii [Kuhl's wart frog]|||Limnonectes kuhlii [Kuhl's wart frog]|||the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia N/A "The hemolytic values of five antimicrobial peptides on rabbit red blood cells at a concentration of 100 µg/ml are as follows: - temporin-LK1: 10.2% - gaegurin-LK1: 5.6% - gaegurin-LK2: 6.2% - rugosin-LK1: 3.8% - rugosin-LK2: 6.1% These values indicate that their hemolytic activity is relatively low, with rugosin-LK1 showing the weakest hemolytic activity.|||the Kuhl’s wart frog, skin secretions, Limnonectes kuhlii, Asia||At a concentration of 100 μM, the hemolysis rate is < 10%.|||Rabbit RBC (6.1% hemolysis at 100 ug/ml)|||Rabbit RBC (6.1% hemolysis at 100 ug/ml)|||Some antimicrobial peptides exhibit hemolytic activities by interacting with eukaryote membranes [3]. In our experi- ments, rabbit red blood cells were used to test hemolytic capabilities of these antimicrobial peptides. Most of them showed a little hemolytic activity. At the concentration of 100 lg/ml, temporin-LK1, gaegurin-LK1, gaegurin-LK2, rugosin-LK1, and rugosin-LK2 induced 10.2, 5.6, 6.2, 3.8, and 6.5 % rabbit red blood cell hemolysis, respectively.|||At 100 ug/ml, rugosin-LK2 induced 6.1%, less hemo.lytic." "Mol Biol Rep . 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||Mol Biol Rep. 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 10.|||23054029|||23054029|||Mol Biol Rep . 2013 Feb;40(2):1097-102. doi: 10.1007/s11033-012-2152-4. Epub 2012 Oct 14.|||Mol Biol Rep. 2013 Feb;40(2):1097-102. Pub-Med." 33 FPDB01013 AP02162|||AP02162|||Bicarinalin " KIKIPWGKVKDFLVGGMKAV" Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anti-MRSA||Anti-S. xylosus and S. aureus. Also: Gram- E. coli CIP 7624, activity value is MIC = 24.4 uM||Anti-C. sakazakii ATCC 29544, activity value is MIC = 5.8||Anti-P. aeruginosa CIP 82118, activity value is MIC = 8.7||Anti-S. enterica ATCC 29934, activity value is MIC = 5.4||Anti-E. hirae CIP 5855, activity value is MIC = 12.2||Anti-S. aureus CIP 53156, activity value is MIC = 3.0||Anti-MRSA ATCC 43300, activity value is MIC = 8.7||Anti-S. xylosus ATCC 35033, activity value is MIC = 0.45||Anti-B. substilis CIP 5262, activity value is MIC = 24.4||Anti-A. niger CIP 143183, activity value is MIC = 0.75||Anti-CAAL 117, activity value is MIC = 17.3||Anti-S. cerevisiae sp, activity value is MIC = 6.1||Anti-and parasite L. infantum, activity value is MIC = 1.5||Antibacterial ; Tetramorium bicarinatum [Myrmicine ant ]||Anti-H. pylori Strain ATCC 43504, activity value is MIC = 8.6 ug/ml venom, the ant, Tetramorium bicarinatu, South America|||Tetramorium bicarinatum [Myrmicine ant ] Helix "The hemolytic values of the novel antimicrobial peptide Bicarinalin and related peptides in the venom of the ponerine ant are as follows: - Bicarinalin: At a concentration of 100 μM (180 μg/ml), the hemolysis rate of human erythrocytes is 10%; the concentration at which 50% hemolysis occurs is approximately 720 μg/ml (log = -0.143). - P17: Shows no hemolytic activity. - Melittin (control): At a concentration of 0.15 μM (0.4 μg/ml), the hemolysis rate of human erythrocytes is 10%; the concentration at which 50% hemolysis occurs is approximately 1.76 × 10⁻³ mg/ml (log = -2.76). These data indicate that the hemolytic activity of Bicarinalin is significantly weaker than that of Melittin, while P17 has no hemolytic effect.|||venom, the ant, Tetramorium bicarinatu|||Staphylococcus aureus, Staphylococcus xylosus, Refer PubMed ID: H. pylori Strain ATCC 43504 (MIC = 8.6 ug/ml) [Refer PubMed Id : 29751064] Acinetobacter baumannii ATCC 19606 (MIC = 4 ug/ml)|||The hemolytic activity of the peptides was compared to that of Melittin against human erythrocytes from healthy donor. Fresh human erythrocytes with heparin were washed three times (0.166667 h at 1000 × g) with PBS and resuspended in the same buffer. The hemolytic activity was quantified by incubating 20 ␮L of serially diluted peptides (2.8 × 10−3000 – 5760 ug/ml) or Melittin (0.11 × 10−3000 – 225 ug/ml) with 80 ␮L of a 4% erythrocytes suspension in PBS for 1 h at 37 ◦C in a 96-well microplate (Nunc Edge 96 Well Microplate). The erythrocyte suspension was then centrifuged (1000 × g for 0.166667 h) and, 80 ␮L of the supernatant were transferred in another line of the microplate; cell lysis was determined spectrophotometrically at 540 nm. Reference samples were employed using hypotonic lysis with Milli-Q sterile water as a 100% lysis or PBS pH 7.4 (in place of the peptide) as a 0% lysis. Three replicates were performed." "Peptides . 2012 Dec;38(2):363-70. doi: 10.1016/j.peptides.2012.08.018. Epub 2012 Sep 7.|||Peptides. 2012 Dec;38(2):363-70.Pub-Med.||Guzman J et al., 2017|||https://pubmed.ncbi.nlm.nih.gov/22960382,|||https://pubmed.ncbi.nlm.nih.gov/22960382,||Refer PubMed Id : 29751064|||Peptides . 2012 Dec;38(2):363-70. doi: 10.1016/j.peptides.2012.08.018. Epub 2012 Sep 7.||Guzman J et al., 2017|||Peptides. 2012 Dec;38(2):363-70.Pub-Med." 20 FPDB01015 AP02201 " KIKFLKVLT" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-and fungus C. albicans ATCC 10231, activity value is MIC = 1 Paenibacillus ehimensis B7 N/A Paenibacillus ehimensis B7 "BMC Microbiol . 2013 Apr 17:13:87. doi: 10.1186/1471-2180-13-87.|||BMC Microbiol. 2013 Apr 17;13(1):87. Pub-Med." 9 FPDB01016 AP02213|||AP02213|||CAMPSQ3846|||DRAMP18188|||Pantinin-1|||AP02213|||DRAMP18188 " GILGKLWEGFKSIV" Anti-Gram+ & Gram-||Antifungal||Anti-MRSA||Anti-MRSA 16472, activity value is MIC = 8||Anti-S. enterica AB 2010185, activity value is MIC = 62||Anti-and fungus C. tropicalis AY 91009, activity value is MIC = 16 uM||Anti-S.aureus, activity value is MIC = 8 uM||Anti-B.magaterium, activity value is MIC = 32 uM||Anti-M.luteus, activity value is MIC = 32 uM||Anti-VRE, activity value is MIC = 28 uM||Anti-MRSA, activity value is MIC = 14 uM||Anti-E.coli, activity value is MIC = 62 uM||Anti-P.putida, activity value is MIC > 87 uM||Anti-K.oxytoca, activity value is MIC > 87 uM||Anti-E.cloacae, activity value is MIC = 76 uM||Anti-S.enterica, activity value is MIC = 72 uM||Anti-Fungus: C.tropicalis, activity value is MIC = 16 uM||Antibacterial||Anti-##Gram-negative bacteria: E.coli, activity value is MIC = 62 uM||Anti-##Fungus: C.tropicalis, activity value is MIC = 16 uM Pandinus imperator|||Pandinus imperator [Emperor scorpion]|||Pandinus imperator (Emperor scorpion)|||Pandinus imperator [Emperor scorpion]|||Pandinus imperator|||Pandinus imperator (Emperor scorpion) N/A "Pandinus imperator||No hemolytic effect is observed at concentrations below 32 uM; at 64 uM, it only induces 21% hemolysis, showing extremely low hemolytic activity.|||Pantinin-1 Hemolytic Values <32 uM: No hemolysis 32 uM: No clear value (<81%) 64 uM: 21% hemolysis Pantinin-2 Hemolytic Values <8 uM: No hemolysis 16 uM: 8% hemolysis 32 uM: 81% hemolysis 64 uM: 100% hemolysis Pantinin-3 Hemolytic Values <8 uM: No hemolysis 16 uM: 70% hemolysis 32 uM: 100% hemolysis|||[Ref.23624072]0% hemolytic activity at 16 uM, 0% hemolytic activity at 32 uM, 20% hemolytic activity at 64 uM against human red bood cells" "Peptides . 2013 Jul:45:28-34. doi: 10.1016/j.peptides.2013.03.026. Epub 2013 Apr 23.|||Peptides. 2013 Jul;45:28-34. Pub-Med.|||23624072|||Peptides 45:28-34(2013)||Ref.23624072|||23624072|||Peptides . 2013 Jul:45:28-34. doi: 10.1016/j.peptides.2013.03.026. Epub 2013 Apr 23.|||Peptides 45:28-34(2013)##Peptides 51:35-45(2014||Ref.23624072|||Peptides. 2013 Jul;45:28-34. Pub-Med." 14 FPDB01017 AP02214|||AP02214|||Pantinin-2|||DRAMP18189|||Pantinin-2|||AP02214|||DRAMP03926|||DRAMP18189 IFGAIWKGISSLL Anti-Gram+ & Gram-||Antifungal||Anti-MRSA||Anti-MRSA 16472, activity value is MIC = 18||Anti-S. enterica AB 2010185, activity value is MIC = 48||Anti-and fungus C. tropicalis AY 91009, activity value is MIC = 16 uM||Antibacterial||Anti-S.aureus, activity value is MIC = 48 uM||Anti-B.magaterium, activity value is MIC = 36 uM||Anti-M.luteus, activity value is MIC = 18 uM||Anti-VRE, activity value is MIC = 36 uM||Anti-MRSA, activity value is MIC = 28 uM||Anti-E.coli, activity value is MIC = 48 uM||Anti-P.putida, activity value is MIC > 87 uM||Anti-K.oxytoca, activity value is MIC > 87 uM||Anti-E.cloacae, activity value is MIC > 87 uM||Anti-S.enterica, activity value is MIC = 68 uM||Anti-Fungus: C.tropicalis, activity value is MIC = 16 uM||Antimicrobial||Anti-Gram+||Anti-Gram- Pandinus imperator|||Pandinus imperator [Emperor scorpion]|||Pandinus imperator (Emperor scorpion)|||Pandinus imperator [Emperor scorpion]|||Pandinus imperator|||Synthetic construct|||Pandinus imperator (Emperor scorpion) N/A "Pandinus imperator||No obvious hemolysis is observed at concentrations below 8 uM; the hemolysis rate is 8% at 16 uM, 81% at 32 uM, and reaches 100% at 64 uM, showing moderate hemolytic activity.|||Pantinin-1 Hemolytic Values <32 uM: No hemolysis 32 uM: No clear value (<81%) 64 uM: 21% hemolysis Pantinin-2 Hemolytic Values <8 uM: No hemolysis 16 uM: 8% hemolysis 32 uM: 81% hemolysis 64 uM: 100% hemolysis Pantinin-3 Hemolytic Values <8 uM: No hemolysis 16 uM: 70% hemolysis 32 uM: 100% hemolysis" "Peptides . 2013 Jul:45:28-34. doi: 10.1016/j.peptides.2013.03.026. Epub 2013 Apr 23.|||Peptides. 2013 Jul;45:28-34.Pub-Med.|||23624072|||Peptides 51:35-45(2014||Ref.23624072|||23624072|||Peptides . 2013 Jul:45:28-34. doi: 10.1016/j.peptides.2013.03.026. Epub 2013 Apr 23.|||Curr Microbiol. 2010 Sep;61(3):169-175.|||Peptides 45:28-34(2013).Peptides 51:35-45(2014|||Peptides. 2013 Jul;45:28-34.Pub-Med." 13 FPDB01018 AP02215|||AP02215|||Pantinin-3|||DRAMP18190|||Pantinin-3|||AP02215|||DRAMP18190 " FLSTIWNGIKSLL" Anti-Gram+ & Gram-||Antifungal||Anti-MRSA||Anti-MRSA 16472, activity value is MIC = 4||Anti-S. enterica AB 2010185, activity value is MIC = 36||Anti-and fungus C. tropicalis AY 91009, activity value is MIC = 17 uM||Antibacterial||Anti-S.aureus, activity value is MIC = 16 uM||Anti-B.magaterium, activity value is MIC = 6 uM||Anti-M.luteus, activity value is MIC = 8 uM||Anti-VRE, activity value is MIC = 4 uM||Anti-MRSA, activity value is MIC = 12 uM||Anti-E.coli, activity value is MIC = 36 uM||Anti-P.putida, activity value is MIC > 87 uM||Anti-K.oxytoca, activity value is MIC = 87 uM||Anti-E.cloacae, activity value is MIC > 87 uM||Anti-S.enterica, activity value is MIC = 84 uM||Anti-Fungus: C.tropicalis, activity value is MIC = 17 uM||Antimicrobial||Anti-Gram+||Anti-Gram- Pandinus imperator|||Pandinus imperator [Emperor scorpion]|||Pandinus imperator (Emperor scorpion)|||Pandinus imperator [Emperor scorpion]|||Pandinus imperator|||Pandinus imperator (Emperor scorpion) N/A "Pandinus imperator||No obvious hemolysis is observed at concentrations below 8 uM; the hemolysis rate rises sharply to 70% at 16 uM and reaches 100% at 32 uM, showing strong hemolytic activity.|||Pantinin-1 Hemolytic Values <32 uM: No hemolysis 32 uM: No clear value (<81%) 64 uM: 21% hemolysis Pantinin-2 Hemolytic Values <8 uM: No hemolysis 16 uM: 8% hemolysis 32 uM: 81% hemolysis 64 uM: 100% hemolysis Pantinin-3 Hemolytic Values <8 uM: No hemolysis 16 uM: 70% hemolysis 32 uM: 100% hemolysis" "Peptides . 2013 Jul:45:28-34. doi: 10.1016/j.peptides.2013.03.026. Epub 2013 Apr 23.|||Peptides. 2013 Jul;45:28-34.Pub-Med.|||23624072|||Peptides 45:28-34(2013)||Ref.23624072|||23624072|||Peptides . 2013 Jul:45:28-34. doi: 10.1016/j.peptides.2013.03.026. Epub 2013 Apr 24.|||Peptides 45:28-34(2013).Peptides 51:35-45(2014|||Peptides. 2013 Jul;45:28-34.Pub-Med." 13 FPDB01024 AP02379|||AP02379|||GNU7|||DRAMP21139|||GNU7|||AP02379|||DRAMP21139 " RLLRPLLQLLKQKLR" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Gram+ B. subtilis, activity value is MIC = 2 ug/ml||Anti-E. faecalis, activity value is MIC = 2 ug/ml||Anti-E. faecium VRE, activity value is MIC = 2 ug/ml||Anti-M. luteus, activity value is MIC = 2 ug/ml||Anti-S. aureus or MRSA, activity value is MIC = 2 ug/ml||Anti-E. coli, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa, activity value is MIC = 2 ug/ml||Anti-S. typhimurium, activity value is MIC = 2 ug/ml||Anti-C. albicans, activity value is MIC = 2 ug/ml||Anti-C. neoformans, activity value is MIC = 2 ug/ml||Anti-and S. cerevisiae, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 32 uM||Anti-E. coli KCTC 2223, activity value is MIC = 8 uM||Anti-S. typhimurium KCTC 2370, activity value is MIC = 16 uM||Anti-S. aureus ATCC 15752, activity value is MIC = 4 uM||Anti-C. albicans ATCC 10231, activity value is MIC = 16 uM||Anti-Bacillus subtilis, activity value is MIC = 2 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 2 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 2 ug/ml||Anti-Escherichia coli, activity value is MIC = 2 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 2 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 2 ug/ml||Anti-Candida albicans, activity value is MIC = 2 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 2 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC = 4 ug/ml||Antibacterial||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 2 ug/ml||Anti-##Fungi : Candida albicans, activity value is MIC = 2 ug/ml de novo designed, man-made sequences|||Synthetic construct|||Synthetic construct|||de novo designed, man-made sequences Helix||Alpha helix "de novo designed, man-made sequences|||Human RBCs [<2.5% hemolysis upto 65 uM]|||- Test subject: human red blood cells, incubation conditions at 37°C for 30 minutes, detection wavelength 567 nm; negative control (PBS only) showed 0% hemolysis, positive control (0.2% Triton X-100) showed 100% hemolysis. - Key results: - Designed peptides GNU5, GNU6, GNU7: At concentrations up to 128 µg/ml, hemolysis rate was 0%, showing no hemolytic activity and excellent safety. - Control peptides: - Magainin 2: Similar to the designed peptides, no hemolysis at 128 µg/ml. - Buforin IIb: At 128 µg/ml, hemolysis rate was 14.5%, indicating some hemolytic activity. - Key correlation: The designed peptides eliminate hemolysis by disrupting the hydrophobic surface of the α-helix (inserting lysine residues) while maintaining high hydrophobicity (46%) and strong antibacterial activity (MIC 1–4 µg/ml, effective against MRSA and VRE), and exhibit no cytotoxicity to human keratinocytes (HaCaT) or fibroblasts (BJ).|||Human RBCs [<2.5% hemolysis upto 65 uM]|||[Ref.23946320] 0% hemolysis at 140 ug/ml against human red blood cells" "J Antimicrob Chemother . 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. Epub 2013 Aug 14.|||J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. PubMed|||31678742|||J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322.||Ref.23946320|||31678742|||J Antimicrob Chemother . 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. Epub 2013 Aug 14.|||J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322.||Ref.23946320|||J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. PubMed" 15 FPDB01027 AP02437|||AP02437|||Trichoplaxin|||Trichoplaxin|||AP02437|||DRAMP31839 " FFGRLKSVWSAVKHGWKAAKSR" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-L. ivanovii, activity value is MIC = 3 uM||Anti-E. faecalis, activity value is MIC = 12.5 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 3||Anti-C. albicans ATCC 90028 and C. parapsilosis ATCC 22019, activity value is MIC = 25||Antibacterial||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3 uM||Anti-Staphylococcus aureus ATCC BAA-44, activity value is MIC = 3 uM||Anti-Listeria ivanovii, activity value is MIC = 3 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 12.5 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 3||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 6 uM||Anti-Acinetobacter baumannii ATCC 19606, activity value is MIC = 3 uM||Anti-Klebsiella pneumoniae ATCC 13883, activity value is MIC = 6 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 25 uM||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 50 uM||Anti-Human breast adenocarcinoma MCF-7, activity value is IC50 = 45||Antimicrobial||Anticancer identified in the EST database, Trichoplax adhaerens|||Trichoplax adhaerens|||identified in the EST database, Trichoplax adhaerens Helix identified in the EST database, Trichoplax adhaerens|||Rat erythrocytes (20% Hemolysis at 800 uM|||Rat erythrocytes (20% Hemolysis at 800 uM|||Rat erythrocytes:20% Hemolysis=800 uM "Biochim Biophys Acta . 2014 May;1838(5):1430-8. doi: 10.1016/j.bbamem.2014.02.003. Epub 2014 Feb 12.|||Biochim Biophys Acta. 2014 May;1838(5):1430-8. doi: 10.1016/j.bbamem.2014.02.003. PubMed|||24530880|||24530880|||Biochim Biophys Acta . 2014 May;1838(5):1430-8. doi: 10.1016/j.bbamem.2014.02.003. Epub 2014 Feb 12.|||Biochim Biophys Acta. 2014 May;1838(5):1430-8.|||Biochim Biophys Acta. 2014 May;1838(5):1430-8. doi: 10.1016/j.bbamem.2014.02.003. PubMed" 22 FPDB01029 AP02447|||AP02447|||Scolopendin 2|||Scolopendin 2|||AP02447 " AGLQFPVGRIGRLLRK" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Gram+ E. faecium ATCC 19434, activity value is MIC = 12.5 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 25 uM||Anti-and MRSA, activity value is MIC = 12.5 uM||Anti-E. coli O157 ATCC 43895, activity value is MIC = 6.3 uM||Anti-S. typhi ATCC 19430, activity value is MIC = 12.5 uM||Anti-P. aeruginosa ATCC 27853 including three resistant strains, activity value is MIC = 6.3||Anti-and fungi C. albicans ATCC 90028, activity value is MIC = 6.3 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 12.5 uM||Anti-T. beigelii KCTC 7707, activity value is MIC = 6.3 uM||Anti-and T. rubrum KCTC 6345, activity value is MIC = 6.3 uM||Anti-Enterococcus faecium ATCC 19434, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 25 uM||Anti-Staphylococcus aureus, activity value is MIC = 12.5 uM||Anti-Escherichia coli O157:H7 ATCC 43895, activity value is MIC = 6.3 uM||Anti-Salmonella typhimurium ATCC 19430, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa 1, activity value is MIC = 6.3 uM||Anti-Pseudomonas aeruginosa 2, activity value is MIC = 12.5 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 6.3 uM||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 12.5 uM||Anti-Trichosporon beigelii KCTC 7707, activity value is MIC = 6.3 uM||Anti-Trichophyton rubrum KCTC 6345, activity value is MIC = 6.3 uM Chinese red-headed centipede Scolopendra subspinipes mutilans, Asia|||Scolopendra subspinipes mutilans|||Chinese red-headed centipede Scolopendra subspinipes mutilans, Asia Helix Chinese red-headed centipede Scolopendra subspinipes mutilans, Asia||Within the concentration range of 1.6 uM to 100 uM, the hemolysis rate of the Scolopendin 2-treated group is consistently 0 ± 0.2% to 0 ± 0.8%.|||Human erythrocytes (0% Hemolysis at 100 uM|||Human erythrocytes (0% Hemolysis at 100 uM|||However, scolopendin 2 and BUF(6–21)showed no hemolytic activity towards human erythrocytes, at any concentration (Table2). These results indicate that scolopendin 2 has potential as an AMP with no hemolytic effect. "Biochim Biophys Acta . 2015 Feb;1848(2):634-42. doi: 10.1016/j.bbamem.2014.11.016. Epub 2014 Nov 22.|||Biochim Biophys Acta. 2015;1848(2):634-642. PubMed|||25462167|||25462167|||Biochim Biophys Acta . 2015 Feb;1848(2):634-42. doi: 10.1016/j.bbamem.2014.11.016. Epub 2014 Nov 22.|||Biochim Biophys Acta. 2015;1848(2):634-642. PubMed" 16 FPDB01045 AP02802|||AP02802|||BacSp222|||Suc-K20-BacSp222|||Suc-K11/K20-BacSp222|||DRAMP18356 " MAGLLRFLLSKGRALYNWAKSHVGKVWEWLKSGATYEQIKEWIENALGWR" Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Anti-B. subtilis ATCC 6633, activity value is MIC = 0.16 uM||Anti-L. lactis subsp. lactis LOCK 0871 strain 239, activity value is MIC = 0.89 uM||Anti-M. luteus ATCC 4698, activity value is MIC = 0.11 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 0.89||Anti-S. epidermidis ATCC 35547, activity value is MIC = 4.4 uM||Anti-S. intermedius R-2725, activity value is MIC = 1.2||Anti-S. pseudintermedius LMG 22219, activity value is MIC = 2.1||Anti-S. saprophyticus ATCC 15305, activity value is MIC = 0.93 uM||Anti-S. pyogenes PCM 465, activity value is MIC = 7.8 uM||Anti-S. sanguinis PCM 2335, activity value is MIC = 3.5 uM||Anti-and C. albicans ATCC 10231, activity value is MIC = 100 uM||Anti-K.pneumoniae ATCC 13886, activity value is MIC > 100 uM||Anti-S.marcescens ATCC 274, activity value is MIC > 100 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 0.16||Anti-Lactococcus lactis subsp. lactis ?OCK 0871 strain 239, activity value is MIC = 0.89||Anti-Micrococcus luteus ATCC 4698, activity value is MIC = 0.11||Anti-Staphylococcus aureus DSM 26258, activity value is MIC = 0.92||Anti-Staphylococcus aureus MRSA USA300 strain FPR3757, activity value is MIC = 0.89||Anti-Staphylococcus aureus KB/8658, activity value is MIC = 1.3||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 1||Anti-Staphylococcus epidermidis ATCC 35547, activity value is MIC = 4.4||Anti-Staphylococcus intermedius ATCC 29663, activity value is MIC = 2||Anti-Staphylococcus intermedius R-2725, activity value is MIC = 1.2||Anti-Staphylococcus pseudintermedius 222, activity value is MIC = 2.1||Anti-Staphylococcus pseudintermedius LMG 22219, activity value is MIC = 0.16||Anti-Staphylococcus saprophyticus ATCC 15305, activity value is MIC = 0.93||Anti-Streptococcus pyogenes PCM 465, activity value is MIC = 7.8||Anti-Streptococcus sanguinis PCM 2335, activity value is MIC = 3.5||Anti-Candida albicans ATCC 10231, activity value is MIC = 100||Antibacterial ; Bacillus subtilis ATCC 6633||Lactococcus lactis LOCK 0871 strain 239||Micrococcus luteus ATCC 4698||Staphylococcus aureus ATCC 25923||Staphylococcus epidermidis ATCC 35547||Staphylococcus intermedius ATCC 29663||Staphylococcus pseudintermedius 22221||Antibacterial||Mammalian cells||Antimicrobial isolated from dog skin lesions, Staphylococcus pseudintermedius strain 222|||Staphylococcus pseudintermedius [Bacteria]|||Synthetic construct|||isolated from dog skin lesions, Staphylococcus pseudintermedius strain 222 Helix "In this document, the key numerical values related to the hemolytic activity of the BacSp222 peptide secreted by Staphylococcus pseudintermedius are as follows: - Test concentration 100 µM: This concentration is much higher than the minimum inhibitory concentration (MIC, 0.11–7.8 µM) of BacSp222 against Gram-positive bacteria, and the hemolysis rate of human red blood cells at this concentration is 40%, showing a certain degree of hemolytic activity. - Test concentration 12.5 µM (approximately 10 times the MIC for Staphylococcus aureus): This concentration is close to the level at which the bacteria produce BacSp222 in vitro. The hemolysis rate of human red blood cells is only 1.82 ± 0.28%, indicating low hemolytic activity. At this concentration, although the hemolysis rate is low, the possibility of increased hemolysis risk due to elevated BacSp222 concentration at local infection sites cannot be excluded. Through hemolysis experiments on human red blood cells, it was found that BacSp222 can cause a higher proportion of red blood cell lysis at high concentrations, but at concentrations close to those produced by the bacteria in vitro, the hemolysis rate remains low. However, the actual concentration and hemolysis risk at infection sites in the body still need to be further studied.|||isolated from dog skin lesions, Staphylococcus pseudintermedius strain 222||Human skin fibroblasts (HSF, ATCC CRL-2522), adipose-derived stem cells (ASCs, ATCC PCS-500-011), and HeLa human epithelioid cervix carcinoma cells (ATCC CCL-2) were maintained in Dulbecco’s modified Eagle’s medium (DMEM, Sigma) containing 1000000 ug/l glucose, 10% (v/v) foetal bovine serum (FBS), 1 U/ml penicillin, 1 μ g/ml streptomycin, and 2.5 μ g/ml amphotericin B. Murine P388/D1 monocyte/macrophage cells (ATCC CCL-46) and murine RAW264.7 macrophage-like cells (ATCC TIB-71) were cultured in DMEM containing 4500000 ug/l glucose, 5% (v/v) FBS, and antibiotics, as indicated above. Keratinocytes from human skin were grown in KBM Gold Medium (Lonza). All cells were incubated in standard conditions (5% CO2, 37 °C, > 95% humidity). For the viability and cytotoxicity tests, the cells were transferred into a 96-well plate at a density of 2 × 105 cells per well. After 24 h, the medium was replaced with 50 μ l of fresh medium containing 5% (v/v) FBS (HSF, ASC, HeLa, and RAW cells) or of KBM Gold medium (keratinocytes), all with BacSp222 at different concentrations. Before use, the peptide solution was tested for lipopolysaccharide (LPS) contamination using an E-TOXATE assay kit (Sigma). The cells were then exposed to BacSp222 for 4 h and then subjected to the lactate dehydrogenase (LDH) and the tetrazolium salt reduction (MTT) assays. LDH release was performed according to the protocol provided by the manufacturer (CytoTox 96 kit, Promega, USA). Briefly, 30 μ l of cultured media was transferred into a microplate and mixed with 30 μ l of an INT substrate. After a 30-min incubation (RT, in the dark), the reaction was stopped, and the absorbance was measured with a microplate reader (PowerWave X, BioTek Instruments) at 490 nm, followed by subtraction of the absorbance reference value at 690 nm. The obtained results were normalized to the value of the total cellular LDH activity (positive control: cells lysed with 1% (v/v) Triton X-100, reflecting maximal LDH release from the cells). For the MTT assay, the cells were incubated with 55 μ l of fresh DMEM containing MTT (500 ug/ml) for 3 h at 37 °C, and then the media was replaced with 100 μ l acidified isopropanol to dissolve the water-insoluble formazan crystals produced in living cells with maintained reductive potential. The absorbance of solubilized purple formazan was measured at 540 nm, followed by subtraction of the absorbance reference value at 690 nm. The obtained results were normalized to the value of the control without BacSp222. To track cell membrane integrity, HSF (2 × 104 cells per well) were incubated in DMEM without phenol red containing 10% (v/v) FBS, 0.5, 15 μ M BacSp222, 0.001 ug/ml propidium iodide (PI, Sigma) and 0.01 ug/ml fluorescein diacetate (FDA, Sigma). The cells were observed using an Eclipse Ti (Nikon) microscope at 488/515–550 nm (FDA) or 540/605–660 nm (PI) excitation/emission wavelengths, respectively. To evaluate haemolytic activity, a suspension of 3% (v/v) human erythrocytes in PBS was incubated for 1 h with various amounts of BacSp222. The amount of released haemoglobin was spectrophotometrically determined at 540 nm and compared with a positive control (erythrocytes lysed with 1% sodium dodecyl sulphate).|||Human red blood cells ( 40% hemolysis at 100 uM)" "Sci Rep . 2015 Sep 28:5:14569. doi: 10.1038/srep14569.|||Sci Rep . 2015 Sep 28:5:14569. doi: 10.1038/srep14569.|||26411997|||34200765|||Sci Rep. 2015 Sep 28;5:14569|||Sci Rep. 2015 Sep 28;5:14569.PubMed" 50 FPDB01046 AP02811|||AP02811|||Histone H2A|||DRAMP018380|||DRAMP18380|||AP02811 " SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAQRVGAGAPVY" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli ML35p, activity value is MIC = 0.7 uM||Anti-L. monocytogenes EGD, activity value is MIC = 1.1 uM||Anti-MRSA ATCC 33591, activity value is MIC = 0.9 uM||Anti-and C. albicans 820, activity value is MIC = 1 uM||Anti-E.coli ML35p, activity value is MIC = 0.7||Anti-L.monocytogenes EGD, activity value is MIC = 1.1||Anti-Methicillin resistant Staphylococcus aureus ATCC 33591, activity value is MIC = 0.9||Anti-C.albicans 820, activity value is MIC = 1||Anti-E. coli ML35p, activity value is MIC = 0.3 uM||Anti-L. monocytogenes EGD, activity value is MIC = 1 uM||Anti-MRSA ATCC 33591, activity value is MIC = 0.6 uM||Anti-C. albicans 820, activity value is MIC = 0.9 uM||Anti-C. albicans 820, activity value is MIC = 1 uM Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii|||Acipenser gueldenstaedtii [Russian sturgeon]|||Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii N/A Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii|||We investigated the hemo lytic activity of acipensins 1, 2, and 6 against human erythrocytes. erythrocyte hemolysis was found not to be observed for the studied peptides at concentrations of 1–40 uM (Fig. 3) "Acta Naturae . 2014 Oct;6(4):99-109.|||Acta Naturae . 2014 Oct;6(4):99-109.|||25558400|||Acta Naturae. 2014 Oct;6(4):99-109|||25558400|||Acta Naturae . 2014 Oct;6(4):99-109.|||Acta Naturae. 2014 Oct;6(4):99-109. PubMed" 50 FPDB01047 AP02812|||AP02812|||Histone H2A|||DRAMP018379|||DRAMP18379|||Histone H2A|||AP02812 " SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLR" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli ML35p, activity value is MIC = 0.3 uM||Anti-L. monocytogenes EGD, activity value is MIC = 1 uM||Anti-MRSA ATCC 33591, activity value is MIC = 0.6 uM||Anti-and C. albicans 820, activity value is MIC = 0.9 uM||Antibacterial||Anti-C. albicans 820, activity value is MIC = 0.9 uM||Anti-E.coli ML35p, activity value is MIC = 0.3||Anti-L.monocytogenes EGD, activity value is MIC = 1.0||Anti-Methicillin resistant Staphylococcus aureus ATCC 33591, activity value is MIC = 0.6||Anti-C.albicans 820, activity value is MIC = 0.9 Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii|||Acipenser gueldenstaedtii [Russian sturgeon]|||Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii|||Acipenser gueldenstaedtii [Russian sturgeon]|||Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii N/A Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii|||We investigated the hemo lytic activity of acipensins 1, 2, and 6 against human erythrocytes. erythrocyte hemolysis was found not to be observed for the studied peptides at concentrations of 1–40 uM (Fig. 3) "Acta Naturae . 2014 Oct;6(4):99-109.|||Acta Naturae . 2014 Oct;6(4):99-109.|||25558400|||Acta Naturae. 2014 Oct;6(4):99-109|||25558400|||Acta Naturae . 2014 Oct;6(4):99-109.|||Acta Naturae. 2014 Oct;6(4):99-109. PubMed" 35 FPDB01060 AP02919|||AP02919|||Phylloseptin-PC, PSN-PC|||Phylloseptin-PC, PSN-PC|||AP02919|||DRAMP32119 " FLSLIPKIATGIAALAKHL" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus, activity value is MIC = 2 uM||Anti-E. coli, activity value is MIC = 8 uM||Anti-P. aeruginosa, activity value is MIC = 32 uM||Anti-and C. albicans, activity value is MIC = 2 uM||Antibacterial ; Synthetic construct||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 2 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 4 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MIC = 2 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MBC = 4 uM||Anti-Candida albicans NCYC 1467, activity value is MIC = 2 uM||Anti-Candida albicans NCYC 1467, activity value is MBC = 2 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 8 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 32 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 64 uM||Anti-Human squamous lung carcinoma NCI-H157, activity value is IC50 = 2.85 uM||Antimicrobial||Anticancer skin secretion, Phyllomedusa camba, South America|||Synthetic construct|||Phyllomedusa camba|||skin secretion, Phyllomedusa camba, South America N/A "In this document, the key values related to the hemolytic activity of the novel antimicrobial peptide PSN-PC (derived from the skin secretion of the toad Phyllomedusa camba) are as follows, determined by horse red blood cell hemolysis assay (with 2% Triton X-100 as 100% hemolysis positive control, PBS as 0% hemolysis negative control): Core Hemolytic Activity Results - Tested concentration range: 1–512 µM - Hemolysis rates at each concentration and key indicators: - 1–8 µM: Hemolysis rate is at a low level, showing no significant hemolytic activity (described in the document as ""low initial stage hemolysis""); this concentration covers its effective antimicrobial concentration against Gram-positive bacteria (such as S. aureus, MRSA) and fungi (C. albicans) (MIC = 2 µM). - 8–64 µM: Hemolysis rate shows a sharp increasing trend, rapidly rising from low to high levels. - 64 µM: Hemolysis rate reaches 100% for horse red blood cells, complete hemolysis. - Half-hemolytic concentration (HC₅₀): The concentration of PSN-PC inducing 50% hemolysis is 23 µM, which is higher than its MIC for most sensitive bacteria (2–8 µM) but lower than the MIC for Pseudomonas aeruginosa (32 µM). Experimental Conditions and Additional Notes - Experimental conditions: 2% horse red blood cell suspensions were co-incubated with different concentrations of PSN-PC at 37°C for 2 hours; after centrifugation, the absorbance of the supernatant at 550 nm was measured. Hemolysis rate was calculated using the formula (hemolysis rate = [(A−A₀)/(Aₓ−A₀)]×100, where A is the sample absorbance, A₀ is the negative control absorbance, and Aₓ is the positive control absorbance). Experiments were repeated multiple times to ensure reproducibility. - Safety relevance: PSN-PC has a low IC₅₀ against non-small cell lung cancer cells (NCI-H157, IC₅₀ = 2.85 µM), but a high IC₅₀ against human microvascular endothelial cells (HMEC-1, IC₅₀ = 51.83 µM), indicating low toxicity to normal cells. Although its HC₅₀ (23 µM) is higher than the MIC for sensitive bacteria, concentration control is necessary during use, especially for pathogens requiring higher concentrations for efficacy (such as P. aeruginosa, MIC = 32 µM), requiring a balance between antimicrobial effectiveness and hemolysis risk.|||skin secretion, Phyllomedusa camba, South America||PSN-PC had a significant anti-proliferative effect on the non-small cell lung cancer cell line NCl-H157 with an IC50 of 2.85 uM (Figure 7a). Comparatively, the human microvessel endothelial cell line HMEC-1 was used to evaluate the inherent cytotoxicity of PSN-PC against normal human cells, which showed an IC50 of 51.83 uM (Figure 7b). PSN-PC had ~100% haemolysis at 64 uM, (Figure 8). The whole haemolytic process was divided into three parts, including a low degree of haemolysis at the initial stage (1–8 uM), a sharp rise in the middle stage (8–64 uM), and finally a constant period of complete haemolysis. The concentration of the test peptide which induced 50% haemolysis (HC50) was 23 uM.|||Staphylococcus aureus NCTC 10788[MIC = 2 uM], Staphylococcus aureus NCTC 10788[MBC = 4 uM], Staphylococcus aureus NCTC 12493[MIC = 2 uM], Staphylococcus aureus NCTC 12493[MBC = 4 uM], Candida albicans NCYC 1467[MIC = 2 uM], Candida albicans NCYC 1467[MBC = 2 uM], Escherichia coli NCTC 10418[MIC = 8 uM], Escherichia coli NCTC 10418[MBC = 8 uM], Pseudomonas aeruginosa ATCC 27853[MIC = 32 uM]||Horse erythrocytes (100% Hemolysis at 64 uM|||Horse erythrocytes (100% Hemolysis at 64 uM|||Horse erythrocytes (100% Hemolysis at 64 uM|||In addition, BombininBO1 has a moderate hemolytic effect on human red blood cells. At a concentration of 26.3 μM, the hemolysis rate of red blood cells is only 2.89%, while at 52.5 μM, the hemolysis rate of red blood cells is 38.05%. Its inhibitory effect on Candida albicans is relatively weak (the minimum inhibitory concentration is 161.1 μM), and its antibacterial effect on Escherichia coli and Staphylococcus aureus is also weak. At a concentration of 40.3 μM, the hemolysis rate of red blood cells is 42.03%, and at 161.1 μM, it reaches 100%.|||Horse erythrocytes: 100% Hemolysis=64 uM; Horse erythrocytes=50% Hemolysis=23 uM" Molecules. 2017 Nov 7;22(11). pii: E1896. doi: 10.3390/molecules22111896.|||Molecules. 2017 Nov 7;22(11). pii: E1896. doi: 10.3390/molecules22111896.|||https://pubmed.ncbi.nlm.nih.gov/29112170|||29112170|||Molecules. 2017 Nov 7;22(11). pii: E1896. doi: 10.3390/molecules22111896.|||Molecules. 2017 Nov 7;22(11):1896. 19 FPDB01063 AP02964|||AP02964|||Python Cathelicidin CATHPb1|||Python Cathelicidin CATHPb1|||AP02964 " KRFKKFFRKIKKGFRKIFKKTKIFIGGTIPI" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-inflammatory||Antibiofilm||Anti-Gram+ S. aureus ATCC25923 or MRSA, activity value is MIC = 4.6||Anti-S. epidermidis, activity value is MIC = 18.75 ug/ml||Anti-N. asteroids, activity value is MIC = 9.38 ug/ml||Anti-B. cereus, activity value is MIC = 1.17 ug/ml||Anti-E. faecalis IS 981, activity value is MIC = 75 ug/ml||Anti-E. faecium IS 1299, activity value is MIC = 9.38 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 9.38 ug/ml||Anti-K. oxytoca, activity value is MIC = 75 ug/ml||Anti-S. paratyphi IS 738, activity value is MIC = 18.75 ug/ml||Anti-D. bacillus, activity value is MIC = 1.17 ug/ml||Anti-K. pneumoniae, activity value is MIC = 18.75 ug/ml||Anti-S. maltophilia, activity value is MIC = 4.69 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 9.38||Anti-and fungi C. albicans, activity value is MIC = 9.38||Anti-V. parahaemolyticus, activity value is MIC = 0.62 uM||Anti-V. splendidus, activity value is MIC = 2.47 uM||Anti-V. vulnificus, activity value is MIC = 4.93 uM||Anti-A. hydrophila, activity value is MIC = 1.23 uM||Anti-A. sobria, activity value is MIC = 2.29 uM||Anti-A.veronii, activity value is MIC = 4.93 uM||Anti-and N. asteroides, activity value is MIC = 4.93||Antibacterial||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 37.5 ug/ml||Anti-Staphylococcus aureus 08032712, activity value is MIC = 37.5 ug/ml||Anti-Staphylococcus aureus 08032810, activity value is MIC = 4.69 ug/ml||Anti-Staphylococcus aureus 08032706, activity value is MIC = 18.75 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 18.75 ug/ml||Anti-Nocardia asteroides, activity value is MIC = 9.38 ug/ml||Anti-Bacillus cereus, activity value is MIC = 1.17 ug/ml||Anti-Enterococcus faecalis 981, activity value is MIC = 75 ug/ml||Anti-Enterococcus faecium 1299, activity value is MIC = 9.38 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 9.38 ug/ml||Anti-Escherichia coli 08040726, activity value is MIC = 9.38 ug/ml||Anti-Escherichia coli 08032813, activity value is MIC = 9.38 ug/ml||Anti-Klebsiella oxytoca, activity value is MIC = 75 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Paratyphi A, activity value is MIC = 18.75 ug/ml||Anti-Shigella sp, activity value is MIC = 1.17 ug/ml||Anti-Klebsiella pneumoniae 08B343, activity value is MIC = 18.75 ug/ml||Anti-Klebsiella pneumoniae 1400, activity value is MIC = 18.75 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 4.69 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 9.38 ug/ml||Anti-Pseudomonas aeruginosa 08031014, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans 08022710, activity value is MIC = 18.75 ug/ml||Anti-Candida albicans 08030401, activity value is MIC = 9.38 ug/ml||Anti-Candida albicans 08022821, activity value is MIC = 18.75 ug/ml||Anti-Candida albicans 08030809, activity value is MIC = 18.75 ug/ml||Anti-Candida albicans 08030102, activity value is MIC = 18.75 ug/ml||Anti-Candida glabrata 08A802, activity value is MIC = 9.38 ug/ml||Anti-Candida glabrata 09050201, activity value is MIC = 18.75 ug/ml Burmese python, Python bivittatu|||Python bivittatu|||Python bivittatu|||Burmese python, Python bivittatu|||Burmese python, Python bivittatu Helix "In this document, the key values related to the hemolytic activity of the novel antimicrobial peptide CATHPb1 derived from the Burmese python (Python bivittatus) were determined through human red blood cell hemolysis assays (with 0.1% Triton X-100 as 100% hemolysis positive control and PBS as 0% hemolysis negative control): Core Hemolytic Activity Results - Test concentration: 100 µg/ml (approximately 2.7–85 times its effective antibacterial concentration MIC = 1.17–37.5 µg/ml) - Hemolysis rate: At a concentration of 100 µg/ml, CATHPb1 caused only 6.63% hemolysis of freshly prepared human red blood cells, far below the safety threshold for hemolytic toxicity in clinical applications, exhibiting extremely low hemolytic activity. Experimental Conditions and Supplemental Notes - Experimental conditions: Series-diluted CATHPb1 was co-incubated with fresh human red blood cell suspension, and the hemolysis rate was calculated by lactate dehydrogenase (LDH) release assay or hemoglobin absorbance measurement. The experiment was repeated multiple times to ensure reproducibility. - Safety relevance: The antibacterial effective concentration of CATHPb1 (MIC against MRSA/VRSA = 1.17–37.5 µg/ml) is far lower than the concentration causing slight hemolysis (100 µg/ml), and the cytotoxicity against human liver cells (HL-7702) and mouse peritoneal macrophages (MPMs) is extremely low (cell death rates at 100 µg/ml were 4.46% and 6.46%, respectively). The degranulation rate of mast cells (LAD2) was only 10.97%, further confirming its safety for eukaryotic cells. - Comparison with homologs: Its homologous peptide CATHPb4 exhibited a hemolysis rate as high as 65.59% at the same concentration. The low hemolytic property of CATHPb1 is significantly superior to other homologous peptides, indicating its potential for clinical application (especially suitable for systemic or local administration).|||Burmese python, Python bivittatu||CATHPb1 up to 100 ug/ml (5-fold higher than MICs) only nduced 6.63% hemolysis of fresh-prepared human erythrocytes, 4.46% and 6.46% death of HL7702 and MPMs, respectively, quantified by MTT and LDH assays (Table S3). In contrast, its orthologs, CATHPb2−6, all showed higher cytotoxicities, especially CATHPb4, which even induced 65.59% hemolysis. In addition, cytotoxicity for neutrophil was also determined by calcein leakage assay,22 which showed little increased fluorescence level of supernatant after treatment of 100 ug/ml CATHPb1 (data not shown).|||Human erythrocytes (6.63% Hemolysis at 100 ug/ml|||The document explicitly provides the specific hemolytic values of CATHPb1, with the core information as follows: Hemolytic values of CATHPb1 In section ""2.8. Toxicity and Stability Evaluations of CATHPb1,"" it is clearly stated that: CATHPb1, at a concentration as high as 100 µg/ml (5 times its minimum inhibitory concentration, MIC), only induces a 6.63% hemolysis rate in freshly prepared human red blood cells. Key comparative information Hemolytic differences among similar peptides: The homologous peptides of CATHPb1 (CATHPb2−6) exhibit significantly higher hemolysis, for example, CATHPb4 can induce 65.59% hemolysis at the same concentration, highlighting the low hemolytic advantage of CATHPb1. Other toxicity-related data: At this concentration (100 µg/ml), CATHPb1 also shows extremely low cytotoxicity to human liver cells HL7702 and mouse peritoneal macrophages (MPMs), with death rates of only 4.46% and 6.46%, respectively; simultaneously, the degranulation effect on mast cells is weak (degranulation rate only 10.97%), further demonstrating its safety toward eukaryotic cells. In summary, even at several times the effective antibacterial concentration (MIC 1.17−37.5 µg/ml), CATHPb1 maintains very low hemolysis (6.63%), which is an important safety feature for its potential as an antibacterial drug.|||Human erythrocytes (6.63% Hemolysis at 100 ug/ml|||The hemolysis rates of HL7702 and MPM against fresh human red blood cells were measured by the tetramethylazobenzene salt colorimetric method and the lactic acid dehydrogenase colorimetric method, and were 6.63%, with mortality rates of 4.46% and 6.46%, respectively. In contrast, their homologs CATHPb2, -, and 6 all showed higher cytotoxicity, especially CATHPb4, with a hemolysis rate of 65.59%.|||——" "J Med Chem . 2018 Mar 8;61(5):2075-2086. doi: 10.1021/acs.jmedchem.8b00036. Epub 2018 Feb 26.|||J Med Chem . 2018 Mar 8;61(5):2075-2086. doi: 10.1021/acs.jmedchem.8b00036. Epub 2018 Feb 26||Ouyang et al., 2022|||29466000|||J Med Chem. 2018 Mar 8;61(5):2075-2086. doi: 10.1021/acs.jmedchem.8b00036. PubMed|||29466000|||J Med Chem . 2018 Mar 8;61(5):2075-2086. doi: 10.1021/acs.jmedchem.8b00036. Epub 2018 Feb 26.||Ouyang et al., 2022|||J Med Chem. 2018 Mar 8;61(5):2075-2086. doi: 10.1021/acs.jmedchem.8b00036. PubMed" 31 FPDB01066 AP02967|||AP02967|||CAMPSQ23004|||Temporin-GHa|||AP02967 " FLQHIIGALGHLF" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anti-MRSA or ATCC 25923, activity value is MIC = 6.8||Anti-B.subtilis ATCC 6633, activity value is MIC = 106.8 uM||Anti-P. gingivalis ATCC 33277, activity value is MIC = 12.5 uM||Anti-B. adolescentis ATCC 15703, activity value is MIC = 50 uM||Anti-B. breve ATCC 15700, activity value is MIC = 100 uM||Anti-L. acidophilus ATCC 4356, activity value is MIC = 25 uM||Anti-S. sanguis ATCC 10556, activity value is MIC = 1.6 uM||Anti-and S. mutans UA159, activity value is MIC = 12.5 uM||Anti-V. alginolyticus IS, activity value is MIC = 26.6 uM||Anti-P.aeruginosa ATCC 15442, activity value is MIC = 106.8 uM||Anti-and C. albicans ATCC 10231, activity value is MIC = 26.6 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC = 26.6 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.8 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 106.8 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 26.6 uM||Anti-Escherichia coli, activity value is MIC = 53.2 uM||Anti-Escherichia coli D31, activity value is MIC = 13.3 uM||Anti-Vibrio alginolyticus, activity value is MIC = 26.6 uM||Anti-Pseudomonas aeruginosa ATCC 15442, activity value is MIC = 106.8 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 26.6 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MBC = 25 uM||Anti-Streptococcus mutans ATCC 25175, activity value is MIC = 25 uM||Anti-Streptococcus mutans ATCC 25175, activity value is MBC = 50 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC > 100 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MBC > 100 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC = 100 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MBC > 100 uM||Anti-Staphylococcus aureus MR, activity value is MIC > 100 uM||Anti-Staphylococcus aureus MR, activity value is MBC > 100 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 25 uM||Anti-Escherichia coli ATCC 25922, activity value is MBC = 50 uM||Anti-Escherichia coli D31, activity value is MIC > 100 uM||Anti-Escherichia coli D31, activity value is MBC > 100 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC > 100 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MBC > 100 uM||Anti-Pseudomonas aeruginosa ATCC 15442, activity value is MIC > 100 uM||Anti-Pseudomonas aeruginosa ATCC 15442, activity value is MBC > 100 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 50 uM||Anti-Candida albicans ATCC 10231, activity value is MFC > 100 uM||Antibacterial skin, Hylarana guentheri, China, Asia.|||Sylvirana guentheri (Hylarana guentheri)|||Sylvirana guentheri (Hylarana guentheri)|||skin, Hylarana guentheri, China, Asia.|||skin, Hylarana guentheri, China, Asia. Helix skin, Hylarana guentheri, China, Asia.|||Human erythrocytes (10% Hemolysis at 20 uM, Human erythrocytes (50% Hemolysis at 115 uM|||Human erythrocytes (10% Hemolysis at 20 uM, Human erythrocytes (50% Hemolysis at 115 uM "Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023.|||Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457.doi: 10.1093/abbs/gmx023.|||28338958, 31752079|||Acta Biochim Biophys Sin (Shanghai). 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023. PubMed|||28338958, 31752079|||Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023.|||Acta Biochim Biophys Sin (Shanghai). 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023. PubMed" 13 FPDB01067 AP02968|||AP02968|||CAMPSQ23005|||Temporin-GHb|||AP02968 " FIHHIIGALGHLF" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Gram+ S. aureus ATCC 43300 MRSA or ATCC 25923, activity value is MIC = 6.8||Anti-B. subtilis ATCC 6633, activity value is MIC = 52.9 uM||Anti-E. coli ATCC 25922 or D31, activity value is MIC = 6.8||Anti-V. alginolyticus IS, activity value is MIC = 13.2 uM||Anti-P. aeruginosa ATCC 15442, activity value is MIC = 26.4 uM||Anti-and C. albicans ATCC 10231, activity value is MIC = 26.4 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC = 26.4 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.8 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 52.9 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 13.2 uM||Anti-Escherichia coli, activity value is MIC = 26.4 uM||Anti-Escherichia coli D31, activity value is MIC = 6.8 uM||Anti-Vibrio alginolyticus, activity value is MIC = 13.2 uM||Anti-Pseudomonas aeruginosa ATCC 15442, activity value is MIC = 26.4 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 26.4 uM||Antibacterial skin, Hylarana guentheri, China, Asia.|||Sylvirana guentheri (Hylarana guentheri)|||Sylvirana guentheri (Hylarana guentheri)|||skin, Hylarana guentheri, China, Asia.|||skin, Hylarana guentheri, China, Asia. N/A skin, Hylarana guentheri, China, Asia. "Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023.|||Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457.doi: 10.1093/abbs/gmx023.|||28338958|||28338958|||Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023.|||Acta Biochim Biophys Sin (Shanghai). 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023. PubMed" 13 FPDB01068 AP02969|||AP02969|||CAMPSQ23006|||Temporin-GHc|||AP02969 " FLQHIIGALTHIF" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anti-Gram+ S. aureus ATCC 43300 MRSA or ATCC 25923, activity value is MIC = 12.9||Anti-B.subtilis ATCC 6633, activity value is MIC = 104 uM||Anti-V. alginolyticus IS, activity value is MIC = 12.9 uM||Anti-P.aeruginosa ATCC 15442, activity value is MIC = 104 uM||Anti-and C.albicans ATCC 10231, activity value is MIC = 104 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC = 51.8 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.9 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 104 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 104 uM||Anti-Escherichia coli, activity value is MIC = 104 uM||Anti-Escherichia coli D31, activity value is MIC = 25.8 uM||Anti-Vibrio alginolyticus, activity value is MIC = 12.9 uM||Anti-Pseudomonas aeruginosa ATCC 15442, activity value is MIC = 104 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 104 uM||Anti-Streptococcus mutans, activity value is MIC = 12.6 uM||Anti-Streptococcus mutans, activity value is MBC > 50 uM||Antibacterial skin, Hylarana guentheri, China, Asia.|||Sylvirana guentheri (Hylarana guentheri)|||Sylvirana guentheri (Hylarana guentheri)|||skin, Hylarana guentheri, China, Asia.|||skin, Hylarana guentheri, China, Asia. Helix skin, Hylarana guentheri, China, Asia.|||Human oral epithelial cells ( at NA , Human erythrocytes (50% Hemolysis at 100 uM|||Human oral epithelial cells ( at NA , Human erythrocytes (50% Hemolysis at 100 uM "Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023.|||Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457.doi: 10.1093/abbs/gmx023.|||28338958|||Acta Biochim Biophys Sin (Shanghai). 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023. PubMed|||28338958|||Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023.|||Acta Biochim Biophys Sin (Shanghai). 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023. PubMed" 13 FPDB01069 AP02970|||AP02970|||CAMPSQ23007|||Temporin-GHd|||AP02970 " FLQHIIGALSHFF" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anti-and fungi. Active against Gram+ S. aureus ATCC 43300 MRSA or ATCC 25923, activity value is MIC = 12.7 uM||Anti-B.subtilis ATCC 6633, activity value is MIC = 102.3 uM||Anti-V. alginolyticus IS, activity value is MIC = 12.7 uM||Anti-P. aeruginosa ATCC 15442, activity value is MIC = 51 uM||Anti-and C. albicans ATCC 10231, activity value is MIC = 25.5 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC = 12.7 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.7 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 102.3 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 12.7 uM||Anti-Escherichia coli, activity value is MIC = 25.5 uM||Anti-Escherichia coli D31, activity value is MIC = 12.7 uM||Anti-Vibrio alginolyticus, activity value is MIC = 12.7 uM||Anti-Pseudomonas aeruginosa ATCC 15442, activity value is MIC = 51 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 25.5 uM||Anti-Streptococcus mutans, activity value is MIC = 13.1 uM||Anti-Streptococcus mutans, activity value is MBC = 26 uM||Antibacterial skin, Hylarana guentheri, China, Asia.|||Sylvirana guentheri (Hylarana guentheri)|||Sylvirana guentheri (Hylarana guentheri)|||skin, Hylarana guentheri, China, Asia.|||skin, Hylarana guentheri, China, Asia. Helix skin, Hylarana guentheri, China, Asia.|||Human oral epithelial cells ( at NA , Human erythrocytes (50% Hemolysis at 50 uM|||Human oral epithelial cells ( at NA , Human erythrocytes (50% Hemolysis at 50 uM "Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023.|||Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457.doi: 10.1093/abbs/gmx023.|||28338958|||Acta Biochim Biophys Sin (Shanghai). 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023. PubMed|||28338958|||Acta Biochim Biophys Sin (Shanghai) . 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023.|||Acta Biochim Biophys Sin (Shanghai). 2017 May 1;49(5):450-457. doi: 10.1093/abbs/gmx023. PubMed" 13 FPDB01074 AP03001|||DRAMP20803|||AP03001|||DRAMP20803 " FFRNLWKGAKAAFRAGHAAWRA" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anti-Gram- E. coli ATCC 25922, activity value is MIC = 6.25 ug/ml||Anti-P. aeruginosa ATCC10662, activity value is MIC = 50 ug/ml||Anti-A. baumannii clinical isolate, activity value is MIC = 6.25 ug/ml||Anti-S. aureus ATCC 25923 or MRSA, activity value is MIC = 3.1 ug/ml||Anti-S. epidermidis ATCC 1435, activity value is MIC = 1.6 ug/ml||Anti-and fungi C. albicans, activity value is MIC = 6.2 ug/ml||Anti-C. tropicalis, activity value is MIC = 6.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.12 ug/ml||Anti-Staphylococcus epidermidis ATCC 1435, activity value is MIC = 1.56 ug/ml||Anti-Staphylococcus aureus MRSA, activity value is MIC = 3.12 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.25 ug/ml||Anti-Pseudomonas aeruginosa ATCC10662, activity value is MIC = 50 ug/ml||Anti-Acinetobacter baumannii clinical isolate, activity value is MIC = 6.25 ug/ml||Anti-Candida albicans clinical isolate, activity value is MIC = 6.25 ug/ml||Anti-Candida tropicalis clinical isolate, activity value is MIC = 6.25 ug/ml||Anti-##Gram-negative bacteria: Escherichia coli ATCC 25922, activity value is MIC = 6.25 ug/ml||Anti-##Fungi:Candida albicans clinical isolate, activity value is MIC = 6.25 ug/ml Tiger tail seahorse, Hippocampus comes|||Hippocampus comes|||Tiger tail seahorse, Hippocampus comes|||Hippocampus comes|||Tiger tail seahorse, Hippocampus comes Alpha helix "In this document, the key values related to the hemolytic activity of the novel antibacterial peptide moronecidin-like derived from seahorse (Hippocampus comes) and its control peptide moronecidin (derived from hybrid striped bass) are as follows, measured by human red blood cell (hRBCs) hemolysis assay (with 0.1% Triton X-100 as the 100% hemolysis positive control and PBS as the 0% hemolysis negative control): Core Hemolytic Activity Results - Test Indicator: The hemolytic toxicity of the two peptides was evaluated using the half-maximal hemolytic concentration (HC_{50}, i.e., the peptide concentration inducing 50% human RBC hemolysis) as the core indicator. - HC_{50} values for each peptide: - Moronecidin-like (novel peptide): HC_{50} = 87.5 μg/mL, showing extremely low hemolytic activity, with its effective antibacterial concentration (against Gram-positive bacteria MIC = 1.56–3.12 μg/mL) far below the HC_{50}, indicating a high therapeutic index. - Moronecidin (control peptide): HC_{50} = 2.34 μg/mL, showing very strong hemolytic activity, significantly higher than the novel peptide (about 37 times that of moronecidin-like), with its effective antibacterial concentration close to the HC_{50}, indicating a high risk of hemolysis. - Dose-Dependent Hemolysis Rate: - At a concentration of 100 μg/mL, moronecidin induced nearly 100% hemolysis of human red blood cells, while the hemolysis rate of moronecidin-like remained below 20%, further confirming that the hemolytic toxicity of moronecidin is much higher than that of moronecidin-like. Experimental Conditions and Supplementary Notes 1. Experimental Conditions: A series of diluted peptides (concentrations 1.56–100 μg/mL) were co-incubated with 4% human red blood cell suspension at 37°C for 1 hour. After centrifugation, the absorbance of the supernatant at 405 nm was measured, and the hemolysis rate was calculated using the formula (Hemolysis rate = [(A_pep − A_PBS)/(A_Tr...|||Tiger tail seahorse, Hippocampus comes||One ofthe main side effects and barriers in the clinical use of moronecidin is high its hemolytic activity; here, we compared the hemolytic activity ofmoronecidin-like peptide and that of moronecidin against hRBCs. Moronecidin showed high he- molytic activity in a dose-dependent manner, while moronecidin-like peptide exhibited significantly lower hemo- lytic activity than moronecidin. The HC50 for moronecidin- like and moronecidin were 87.5 and 2.34 ug/ml, respectively (Fig. 7a). In next step, we assayed cytotoxic activity of moronecidin-like and moronecidin against a mammalian cell, human embryonic kidney cells 293 (HEK-293). Consistent with hemolytic results, moronecidin-like showed significantly lower cytotoxic activity against HEK-293 cells compared with moronecidin (Fig. 7b).|||Specific hemolytic data for the two antimicrobial peptides (moronecidin-like and moronecidin) are clearly provided in the document, with the following core information: 1. Key hemolytic indicators (HCYQ) moronecidin-like (novel antimicrobial peptide of hippocampal origin): H50 hemolytic concentration of human red blood cells (hRBCs) HC-60 = 87.5 ug/ml. moronecidin (hybrid striped sea bass-derived antimicrobial peptide, control group): half hemolytic concentration of human red blood cells HC-60 = 2.34 ug/ml. HCBYL refers to the peptide concentration that induces 50% red blood cell hemolysis. The higher the value, the lower the hemolysis and the higher the safety. The above data indicate that moronecidin-like is significantly less hemolytic than moronecidin. 2. Background and details of hemolytic experiment Experimental method: human red blood cell suspension (4% v/v,PBS) was incubated with different concentrations of peptide (1.56~100 ug/ml) for 1 hour (37°C), and the absorbance of the supernatant at 405 nm (reflecting the amount of hemoglobin released) was detected after centrifugation. With 0.1 Triton X-100 treatment group as 100% hemolysis positive control, PBS treatment group as negative control, the hemolysis rate was calculated by the formula: \text {Hemolysis Rate (%)} = \left[\frac{A_{\ text {Peptide Treatment Group}}-A_{\ text{PBS Group }}}{ A_{\ text{0.1% Triton X-100 Group}}-A_{\ text{PBS Group }}}\ right] \times 100 Concentration dependence: moronecidin showed obvious dose-dependent hemolysis (the higher the concentration, the higher the hemolysis rate), and the hemolysis rate of moronecidin-like in the whole concentration range (1.56~100 ug/ml) tested was significantly lower than that of moronecidin with the same concentration (see Figure 7a). Taken together, moronecidin-like exhibits lower hemolysis with its higher HCYB value, which is an important safety advantage as a potential clinical antimicrobial agent.|||Hemolytic core values • Moronecidin-like (a novel antimicrobial peptide derived from seahorse): Half hemolytic concentration against human red blood cells (hRBCs) HC_{50} = 87.5 μg/ml • Moronecidin (antimicrobial peptide derived from hybrid striped bass, control): Half hemolytic concentration against human red blood cells (hRBCs) HC_{50} = 2.34 μg/ml|||[Ref.30039186] 50% hemolysis at 87.5 ug/ml,25% hemolysis at 50 ug/ml,60% hemolysis at 100 ug/ml against human red cells|||One of the main side effects and barriers in the clinical use of moronecidin is high its hemolytic activity ; here, we compared the hemolytic activity of moronecidin-like peptide and that of moronecidin against hRBCs. Moronecidin showed high hemolytic activity in a dose-dependentmanner, while moronecidinlike peptide exhibited significantly lower hemo lytic activity than moronecidin.The HC50 for moronecidin like and moronecidin were 87.5 and 2.34 ug/ml, respectively (Fig. 7a)." "Mar Biotechnol (NY) . 2018 Dec;20(6):718-728. doi: 10.1007/s10126-018-9843-3. Epub 2018 Jul 23.|||Mar Biotechnol (NY). 2018 Jul 23. 20 (6), 718-728. doi: 10.1007/s10126-018-9843-3. PubMed|||Mar Biotechnol (NY). 2018 Dec;20(6):718-728.||Ref.30039186|||Mar Biotechnol (NY) . 2018 Dec;20(6):718-728. doi: 10.1007/s10126-018-9843-3. Epub 2018 Jul 23.|||Mar Biotechnol (NY). 2018 Dec;20(6):718-728.||Ref.30039186|||Mar Biotechnol (NY). 2018 Jul 23. 20 (6), 718-728. doi: 10.1007/s10126-018-9843-3. PubMed" 22 FPDB01075 AP03010|||AP03010|||Triintsin|||Triintsin|||AP03010 " GFGCPLNERECHSHCQSIGRKFGYCGGTLRLTCICGKE" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus AB94004 or ATCC25923 or ATCC6538, activity value is MIC = 0.06||Anti-S. epidermidis AB208187 or AB208188, activity value is MIC = 4||Anti-M. luteus AB93113, activity value is MIC = 0.06 uM||Anti-B. subtilis AB91021, activity value is MIC = 0.25 uM||Anti-G- E. coli AB94012 or ATCC25922, activity value is MIC = 0.06||Anti-P. aeruginosa ATCC9027 or ATCC27853, activity value is MIC = 0.06||Anti-K. pneumoniae RM3017, activity value is MIC = 0.25 uM||Anti-C. albicans RM2018, activity value is MIC = 16 uM||Anti-and C. parapsilosis RM1003, activity value is MIC = 16 uM||Antibacterial||Anti-S. aureus AB94004, activity value is MIC = 0.25 uM||Anti-S. aureus ATCC25923, activity value is MIC = 0.25 uM||Anti-S. aureus ATCC6538, activity value is MIC = 0.06 uM||Anti-S. AB20891, activity value is MIC = 32 uM||Anti-S. epidermidis AB208187, activity value is MIC = 8 uM||Anti-S. epidermidis AB208188, activity value is MIC = 4 uM||Anti-E. coli AB94012, activity value is MIC = 0.25 uM||Anti-E. coli ATCC25922, activity value is MIC = 0.06 uM||Anti-P. aeruginosa ATCC9027, activity value is MIC = 0.06 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 0.25 uM||Anti-S. aureus RM101, activity value is MIC = 0.5 uM||Anti-MRSA RM329, activity value is MIC = 32 uM||Anti-MRSA P1374, activity value is MIC = 32 uM||Anti-C. parapsilosis RM1003, activity value is MIC = 16 uM human pathogenic fungus, Trichophyton interdigitale|||Trichophyton interdigitale|||Trichophyton interdigitale|||human pathogenic fungus, Trichophyton interdigitale|||human pathogenic fungus, Trichophyton interdigitale Bridge 9r591temhjn6g9dm6rsr|||human pathogenic fungus, Trichophyton interdigitale|||Human red blood cells(23.5% hemolysis at 1000 ug/ml)|||Human red blood cells(23.5% hemolysis at 1000 ug/ml)|||Some AMPs were terminated from further development as candidates for antibacterial agents due to hemolytic activities. Therefore, the released hemoglobin from erythrocytes was determined. At the final concentrations of 1000, 500, 250, 125, 62.5 and 32.25 ug/ml, the hemolysis hRBCs was 23.5%, 14.1%, 7.9%, 5.4%, 3.2% and 1.1%, respectively (Fig. S1). "Peptides . 2018 Sep:107:61-67. doi: 10.1016/j.peptides.2018.08.003. Epub 2018 Aug 10.|||Peptides . 2018 Sep:107:61-67.doi: 10.1016/j.peptides.2018.08.003.Epub 2018 Aug 10.|||30102941|||30102941|||Peptides . 2018 Sep:107:61-67. doi: 10.1016/j.peptides.2018.08.003. Epub 2018 Aug 10.|||Peptides. 2018 Aug 10. 107, 61-67. doi: 10.1016/j.peptides.2018.08.003. PubMed" 38 FPDB01076 AP03015|||AP03015|||Dermaseptin DRS-CA-1|||Dermaseptin DRS-CA-1|||AP03015 " ALWKDLLKNVGKAAGKAVLNKVTDMVNQ" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-S. aureus MRSA, activity value is MIC = 4||Anti-E. coli, activity value is MIC = 4 uM||Anti-P. aeruginosa, activity value is MIC = 8 uM||Anti-K. pneumoniae, activity value is MIC = 8 uM||Anti-and E.faecalis, activity value is MIC = 128 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 4 uM Phyllomedusa camba, Peru, South America|||Phyllomedusa camba|||Phyllomedusa camba|||Phyllomedusa camba, Peru, South America Helix "This document focuses on the study of novel dermaseptin antimicrobial peptides discovered from the secretions of two types of frog skin, involving multiple aspects such as peptide cloning, synthesis, antimicrobial activity, and hemolytic activity testing. Among these, hemolytic activity was tested using horse red blood cells, with 1% DMSO as the negative control and Triton X-100 as the positive control. The hemolysis rate and the half-maximal hemolytic concentration (HC_{50}) were calculated by measuring absorbance at 550 nm. The specific values are as follows: Table Peptide | Half-Maximal Hemolytic Concentration (μM) | Hemolytic Activity Analysis --- | --- | --- DRS-CA-1 | 114.7 | At MIC or MBC concentrations, there is no significant hemolytic activity against the tested microorganisms except for Enterococcus faecalis; compared to other peptides with high hemolytic activity, this peptide has a lower hemolysis rate at relatively low concentrations and causes minimal damage to red blood cells. DRS-DU-1 | 216.6 | Has strong antimicrobial activity, with no significant hemolytic activity at MIC or MBC concentrations except against Enterococcus faecalis; higher than DRS-CA-1, indicating lower toxicity to red blood cells and causing less damage to normal cells while maintaining antimicrobial effects. DP-1 | | Has relatively low antimicrobial activity and almost no hemolytic activity; even at higher concentrations, it does not show significant hemolysis, making it safe for red blood cells, though its antimicrobial potency is weak. DP-2 | | Antimicrobial activity is restored, and its activity against Enterococcus faecalis is higher than that of natural peptides; shows no significant hemolytic activity, indicating a low risk of red blood cell damage while exerting antimicrobial effects, with potential application value.|||Phyllomedusa camba, Peru, South America||The MIC, MBC and HC50 values of all the peptides obtained from antimicrobial and hemolysis assays are summarized in Table 2. The two natural peptides, DRS-CA-1 and DRSDU-1, showed the same MIC values (4 uM) against S. aureus and E. coli and C. albicans. DRS-DU-1 was twofold more potent against MRSA, E. faecalis, K. pneumoniae and P. aeruginosa than DRS-CA-1. The MBC values of two natural peptides against seven tested microorganisms were two or four-fold higher than respective MICs. No obvious hemolysis activity was detected at the MIC or MBC concentrations except against E. faecalis. The two designed peptides also exhibited broad spectrum antimicrobial activities against the seven tested microorganisms, though the potency of DP-1 was much lower. However, the antimicrobial activities of DP-2 were restored comparing to DP-1. Additionally, the antimicrobial potency of DP-2 on E. faecalis was higher than the natural peptides.|||Horse erythrocytes (50% Hemolysis at 114.7 uM)|||Horse erythrocytes (50% Hemolysis at 114.7 uM)|||DRS-CA-1 and DRS-DU-1 exhibited strong antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi with no obvious hemolytic activity, and almost the same proportion of polar residues and nonpolar residues as well as the a-helical structure." "PeerJ . 2018 Sep 19:6:e5635. doi: 10.7717/peerj.5635. eCollection 2018.|||PeerJ . 2018 Sep 19:6:e5635. doi: 10.7717/peerj.5635. eCollection 2018.|||30258724|||30258724|||PeerJ . 2018 Sep 19:6:e5635. doi: 10.7717/peerj.5635. eCollection 2018.|||PeerJ. 2018 Sep 19;6:e5635. doi: 10.7717/peerj.5635. PubMed" 28 FPDB01079 AP03025|||AP03025|||Dicentracin-like " FLRSLLRGAKAIYRGARAGWRG" Anti-Gram+ & Gram-||candidacidal||Anti-MRSA||Anti-E. coli ATCC 25922, activity value is MIC = 4.68 ug/ml||Anti-P. aeruginosa ATCC10662, activity value is MIC = 37.5 ug/ml||Anti-A. baumannii Clinical isolate, activity value is MIC = 18.75 ug/ml||Anti-S. aureus ATCC 25923 or MRSA, activity value is MIC = 4.68 ug/ml||Anti-S. epidermidis ATCC 1435, activity value is MIC = 1.17 ug/ml||Anti-clinical strains C. albicans, activity value is MIC = 4.68||Antibacterial Asian sea bass, Lates calcarifer|||Lates calcarifer [Asian sea bass]|||Asian sea bass, Lates calcarifer N/A erlynitwai5diy0f0vqf|||Asian sea bass, Lates calcarifer||Cytotoxicity ofsome AMPs is the main barrier to the clinical use ofthem; the hemolytic activity ofthe dicentracin-like peptide against human red blood cells (hRBCs) was examined in comparison to moronecidin. Moronecidin showed higherhemolyticactivity than dicentracinlike peptide, the HC50 for moronecidin and dicentracin-like were 57 ug/ml and 2.34 ug/ml, respectively (Fig 8). Dicentracin-like did not show100% hemolytic activity even in the peptide concentration of75 ug/ml.|||human RBC ( 2.34 ug/ml)|||Moronecidin showed higherhemolyticactivity than dicentracin like peptide, the HC 50 for moronecidin and dicentracin-like were 57 ug/ml and 2.34 ug/ml, respectively (Fig 8). Dicentracin-like did not show100% hemolytic activity even in the peptide concentration of 75 ug/ml. "PLoS One . 2018 Oct 26;13(10):e0206578. doi: 10.1371/journal.pone.0206578. eCollection 2018.|||PLoS One . 2018 Oct 26;13(10):e0206578. doi: 10.1371/journal.pone.0206578. eCollection 2018|||30365554|||PLoS One. 2018 Oct 26;13(10):e0206578. doi: 10.1371/journal.pone.0206578. PubMed" 22 FPDB01080 AP03048|||AP03048|||Nigrocin-HLM GLLSGILGAGKKIVF Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anti-S. aureus NCTC10788, activity value is MIC = 2.9 uM||Anti-E. coli NCTC10418, activity value is MIC = 12 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 47 uM||Anti-and C. albicans NCYC1467, activity value is MIC = 2.9 uM||Anti-Staphylococcus aureus, activity value is MIC = 2.94 ug||Anti-Escherichia coli, activity value is MIC = 11.77 ug||Anti-Candida albicans, activity value is MIC = 2.94 ug||Anti-Pseudomonas aeruginosa, activity value is MIC = 47.08 ug||Anti-MRSA, activity value is MIC = 5.89 ug||Anti-MRSA, activity value is MIC = 1.47 ug||Anti-DTMR8, activity value is MIC = 1.47 ug||Anti-DTMR24, activity value is MIC = 1.47 ug||Anti-DTMR37, activity value is MIC = 1.47 ug||Anti-DTMR121, activity value is MIC = 1.47 ug engineered, Motif-Targeted Peptide Design|||Synthetic construct Helix "sje77a9ccf9q4ur2p1zy|||engineered, Motif-Targeted Peptide Design|||Horse erythrocytes (100% hemolysis at 512 uM)|||The document clearly provides hemolytic data for two antimicrobial peptides (the natural peptide nigrocin-HL and the modified peptide nigrocin-HLM), with the core information summarized as follows: 1. Key Hemolytic Properties nigrocin-HL (natural peptide): At its minimum inhibitory concentration (MIC) against tested microorganisms, it can induce significant hemolytic activity (toward horse red blood cells), and the hemolysis rate increases further with higher concentrations. nigrocin-HLM (modified peptide): Exhibits extremely low hemolytic activity—even at concentrations where it exerts bactericidal effects, the hemolysis rate is negligible; no significant hemolytic activity is detected even at concentrations up to 128 μM (Figure 5C). 2. Experimental Background and Basis Experimental method: Red blood cell suspensions were prepared using defibrinated horse blood. Peptides at different concentrations (1–512 μM) were co-incubated with red blood cells, and the absorbance of the supernatant at specific wavelengths was measured to reflect the release of hemoglobin. 0.1% Triton X-100 treated samples were used as the 100% hemolysis positive control, and red blood cell suspensions without peptide were used as the negative control. Safety comparison: The natural peptide nigrocin-HL showed cytotoxicity to human keratinocytes (HaCaT) and human bronchial epithelial cells (16HBE) at concentrations as low as 32 μM; in contrast, the modified peptide nigrocin-HLM showed no significant effect on the viability of these two normal cell types even at concentrations up to 512 μM (Figures 5A and 5B). Combined with its extremely low hemolytic activity, this demonstrates that peptide modification significantly improves safety. In summary, nigrocin-HLM, modified by replacing the ""Rana box"" motif with amidated phenylalanine, greatly reduces hemolytic activity while enhancing antibacterial activity, providing a solid safety basis for its development as a clinical anti-infective candidate drug.|||In addition, hemolytic capacities of these two AMPs were measured against horse erythrocytes.As shown in Figure 5C,where as the natural peptide induced obvious hemolysis at itsMICs against tested microorganisms, the modified nigrocin-HLM showed negligible hemolytic activity even at the concentrations for it to exert bactericidal effects.Infact,nigrocin-HLM was found to be devoid of hemolytic activity up to128 uM." "Front Microbiol . 2018 Nov 28:9:2846. doi: 10.3389/fmicb.2018.02846. eCollection 2018.|||Front Microbiol . 2018 Nov 28:9:2846. doi: 10.3389/fmicb.2018.02846. eCollection 2018.|||30555431|||Front Microbiol. 2018 Nov 28;9:2846. doi: 10.3389/fmicb.2018.02846. PubMed|||Front Microbiol. 2018 Nov 28;9:2846. doi: 10.3389/fmicb.2018.02846. PubMed" 15 FPDB01081 AP03059|||AP03059|||Japonicin-2LF|||Japonicin-2LF|||AP03059|||DRAMP35663 " FIVPSIFLLKKAFCIALKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Antibiofilm||Anti-S. aureus NCTC 10788 or MRSA NCTC 12493, activity value is MIC = 4 uM||Anti-MRSA B038 V1S1 A, activity value is MIC = 8 uM||Anti-E. coli NCTC 10418, activity value is MIC = 16 uM||Anti-P.aeruginosa ATCC 27853, activity value is MIC > 512 uM||Anti-and C. albicans NCYC 1467, activity value is MIC = 4 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 4 uM||Anti-Methicillin-resistant Staphylococcus aureus NCTC 12493, activity value is MIC = 4 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 16 uM||Anti-Candida albicans NCYC 1467, activity value is MIC = 4 uM||Anti-MRSA B042 V2E1 A, activity value is MIC = 8 uM||Antimicrobial||Anticancer skin secretion, Fujian Large-headed Frog, Limnonectes fujianensis, China, Asia|||Limnonectes fujianensis [Fujian Large-headed Frog]|||Animalia|||skin secretion, Fujian Large-headed Frog, Limnonectes fujianensis, China, Asia Helix "In this document, the key values related to the hemolytic activity of the novel antimicrobial peptide Japonicin-2LF, derived from the skin of the Fujian large-headed frog (Limnonectes fujianensis), were measured through a horse red blood cell hemolysis assay (with 1% Triton X-100 as 100% hemolysis positive control and PBS as 0% hemolysis negative control): Core Hemolytic Activity Results - Test concentration range: 1–512 µM (covering its effective antimicrobial concentrations, with MIC = 4–16 µM for sensitive bacteria, and MIC = 8 µM for CF clinical isolate MRSA) - Hemolysis rate at each concentration: - ≤32 µM concentration: Japonicin-2LF caused less than 25% hemolysis of horse red blood cells. This concentration range includes its effective antimicrobial concentrations against most sensitive bacteria (such as S. aureus and MRSA) (4–8 µM), indicating low hemolytic toxicity while exerting antimicrobial effects. - ≥64 µM concentration: Hemolysis rate significantly increased, exceeding 80%, indicating that hemolytic toxicity is significantly enhanced at high concentrations, and such concentrations should be avoided in clinically relevant scenarios.|||skin secretion, Fujian Large-headed Frog, Limnonectes fujianensis, China, Asia|||Horse erythrocytes (64 uM)|||The document clearly provides hemolytic data of the novel antimicrobial peptide Japonicin-2LF on horse red blood cells, with the core information as follows: Hemolytic values of Japonicin-2LF The hemolysis of this peptide was measured by the hemolysis rate on 2% horse red blood cell suspension at different concentrations, with the specific results as follows: At concentrations ≥64 μM: Hemolysis rate exceeds 80%, showing strong hemolytic activity. At concentrations <64 μM: Hemolysis rate is below 25%, showing weak hemolytic activity. The experiment used 1% Triton X-100 treated group as 100% hemolysis positive control and PBS as negative control, and the hemolysis rate was calculated by measuring absorbance at 550 nm (Figure 7a). In addition, the cytotoxicity of this peptide to human lung epithelial cancer cells (NCI-H23) (LDH release and MTT assay) also appeared starting from 64 μM, consistent with the starting concentration of hemolytic activity, suggesting that its toxicity to mammalian cells is concentration-dependent and related to hemolysis.|||Horse erythrocytes (64 uM)" "Biochim Biophys Acta Gen Subj . 2019 May;1863(5):849-856. doi: 10.1016/j.bbagen.2019.02.013. Epub 2019 Feb 22.|||Biochim Biophys Acta Gen Subj . 2019 May;1863(5):849-856. doi: 10.1016/j.bbagen.2019.02.013. Epub 2019 Feb 22.|||30802593|||Biochim Biophys Acta Gen Subj. 2019 Feb 22;1863(5):849-856. doi: 10.1016/j.bbagen.2019.02.013. PubMed|||30802593|||Biochim Biophys Acta Gen Subj . 2019 May;1863(5):849-856. doi: 10.1016/j.bbagen.2019.02.013. Epub 2019 Feb 22.|||Biochim Biophys Acta Gen Subj. 2019 May;1863(5):849-856.|||Biochim Biophys Acta Gen Subj. 2019 Feb 22;1863(5):849-856. doi: 10.1016/j.bbagen.2019.02.013. PubMed" 20 FPDB01092 AP03170|||AP03170|||Brevinin-2GHk|||Brevinin-2GHk|||AP03170 " GFSSLFKAGAKYLLKQVGKAGAQQL" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Interestingly||this 25-residue peptide gained both activity and cell selectivity. Broadly active against Gram+||Gram-||and fungi such as S. aureus||E. faecalis||MRSA||E. coli||P. aeruginosa||K. pneumoniae||and C. albicans.||Human microvascular endothelial cells HMEC-1 (18% Killing at 100 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 4 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 8 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MIC = 4 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MBC = 16 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MIC = 4 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MBC = 16 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 4 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 32 uM||Anti-Klebsiella pneumoniae ATCC 43816, activity value is MIC = 16 uM||Anti-Klebsiella pneumoniae ATCC 43816, activity value is MBC = 32 uM||Anti-Candida albicans NCYC 1467, activity value is MBC = 4 uM||Anti-Candida albicans NCYC 1467, activity value is MBC = 16 uM derived from the parent brevinin peptide|||Synthetic construct|||Synthetic construct|||derived from the parent brevinin peptide Helix "In “Brevinin-2GHk from Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity,” the hemolytic activity of the novel antimicrobial peptide Brevinin-2GHk (BR2GK), identified from the skin secretions of the marsh frog, as well as that of its truncated analogs, was investigated; the relevant values are as follows: -BR2GK: Exhibits significant hemolytic activity starting at 32 µM, with a hemolysis rate exceeding 40% at 256 µM. -BR2GK(1-25)a exhibited the strongest cytotoxicity among the truncated analogs; however, at 256 µM, the hemolysis rate was only approximately 20%, with significant hemolytic activity observed starting at 32 µM. -The other four derivatives ([P14]BR2GK(1-25)a, [A14]BR2GK(1-25)a, [K14]BR2GK(1-25)a, [R14]BR2GK(1-25)a): showed no significant cytotoxicity to red blood cells, with hemolysis rates all below 5%.|||derived from the parent brevinin peptide||BR 2GK and BR 2GK (1-25) a exhibited significant hemolytic activity at 32 µM (Table S4), with BR 2GK causing more than 40% hemolysis at 256 µM. Meanwhile, BR 2GK (1-25) a showed the greatest cytotoxicity among the truncated derivatives, although it only induced about 20% hemolysis at the same concentration.|||Human microvascular endothelial cells HMEC-1 (18% Killing at 100 uM|||Human microvascular endothelial cells HMEC-1 (18% Killing at 100 uM|||BR 2GK and BR 2GK (1-25) a exhibited significant hemolytic activity at 32 µM (Table S4), with BR 2GK causing more than 40% hemolysis at 256 µM. Meanwhile, BR 2GK (1-25) a showed the greatest cytotoxicity among the truncated derivatives, although it only induced about 20% hemolysis at the same concentration.|||Additionally, BR2GK and BR2GK(1-25)a showed significant hemolytic activity from 32 uM (Table S4), where BR2GK resulted in more than 40% hemolysis at 256 uM. Whilst, BR2GK(1-25)a exhibited the most cytotoxic e ects amongst the truncated derivatives, although it only exerted around 20% hemolysis at the same concentration." "Antibiotics (Basel) . 2020 Feb 14;9(2):85. doi: 10.3390/antibiotics9020085.|||Antibiotics (Basel) . 2020 Feb 14;9(2):85. doi: 10.3390/antibiotics9020085.|||32075067|||32075067|||Antibiotics (Basel) . 2020 Feb 14;9(2):85. doi: 10.3390/antibiotics9020085.|||Antibiotics (Basel). 2020;9(2):E85. PubMed" 25 FPDB01093 AP03178|||AP03178|||Brevinin-1GHa|||Brevinin-1GHa|||AP03178 " FLGAVLKVAGKLVPAAICKISKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anti-F) Gram+ S. aureus or MRSA, activity value is MIC = 2||Anti-E. faecalis, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-K. pneumoniae, activity value is MIC = 8 uM||Anti-P. aeruginosa, activity value is MIC = 32 uM||Anti-C. albicans, activity value is MIC = 2 uM||Antibacterial||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 2 uM skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia|||Hylarana guentheri|||Hylarana guentheri|||skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia|||skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia N/A "In this document, the key values related to hemolysis for the novel antimicrobial peptide Brevinin-1GHa derived from the skin of the swamp frog (Hylarana guentheri) and its analogs Brevinin-1GHb and Brevinin-1GHc are as follows, determined by a horse red blood cell hemolysis assay (with 2% Triton X-100 as the 100% hemolysis positive control and PBS as the 0% hemolysis negative control): Core Hemolytic Activity Results - Test concentration range: 1–512 µM (covering the effective antimicrobial concentrations of the three peptides, with Brevinin-1GHa having an MIC against S. aureus of 2 µM, Brevinin-1GHb showing only weak activity against S. aureus with an MIC of 512 µM, and Brevinin-1GHc having an MIC against S. aureus of 16 µM) - Hemolysis values of each peptide: - Brevinin-1GHa (natural peptide containing a C-terminal Rana-box): - At a concentration of 16 µM, the hemolysis rate is close to 20%; - Its effective antimicrobial concentrations (e.g., MIC against S. aureus = 2 µM, MIC against C. albicans = 2 µM) are much lower than the concentration at which significant hemolysis occurs, indicating a low risk of hemolysis during antimicrobial activity, though there is still some hemolytic toxicity at higher concentrations. - Brevinin-1GHb (truncated peptide lacking the Rana-box): - Only at a concentration of 512 µM does the hemolysis rate approach 20%; - This concentration is far higher than its sole antimicrobial active concentration (MIC against S. aureus = 512 µM), and it has no antimicrobial activity against other tested strains, indicating extremely low hemolytic toxicity but weak antimicrobial activity. - Brevinin-1GHc (modified peptide with the Rana-box transferred to the central region): - At a concentration of 128 µM, the hemolysis rate approaches 20%; - Its effective antimicrobial concentration (e.g., MIC against S. aureus = 16 µM) is lower than the concentration at which significant hemolysis occurs, and its hemolytic activity is significantly lower than that of the natural peptide Brevinin-1GHa, although its antimicrobial activity is also slightly reduced compared to the natural peptide.|||skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia|||Horse erythrocytes (20% Hemolysis at 16 uM)|||The document clearly provides hemolytic data of the peptides Brevinin-1GHa, Brevinin-1GHb, and Brevinin-1GHc on horse red blood cells. The core information is as follows: 1. Key hemolytic values (for horse red blood cells) Brevinin-1GHa: Hemolysis rate is approximately 20% at a concentration of 16 µM. Brevinin-1GHb: Hemolysis rate is approximately 20% at a concentration of 512 µM; no hemolytic activity at 256 µM. Brevinin-1GHc: Hemolysis rate is approximately 20% at a concentration of 128 µM. 2. Supplementary notes Hemolysis tests used PBS as a negative control (no hemolysis) and 2% Triton X-100 as a positive control (complete hemolysis), and hemolysis rates of each peptide were calculated by comparison. Effect of structural modifications on hemolysis: Brevinin-1GHb with the Rana box removed (net charge 2, no hydrophobic face) shows significantly reduced hemolysis, requiring very high concentrations (512 µM) to reach 20% hemolysis. Brevinin-1GHc with the Rana box moved to the center (net charge 5, reduced α-helical content) shows a hemolysis rate of 20% at 128 µM, which is lower than Brevinin-1GHa (16 µM for 20%), but its antibacterial activity also decreases correspondingly.|||Horse erythrocytes (20% Hemolysis at 16 uM)|||Brevinin-1GHa, Brevinin-1GHb, and Brevinin-1GHc exhibited a hemolysis rate near 20% on horse erythrocytes with the concentration at 16, 512, and 128 uM, respectively," "Toxins (Basel) . 2018 Oct 13;10(10):413. doi: 10.3390/toxins10100413.|||Toxins (Basel) . 2018 Oct 13;10(10):413. doi: 10.3390/toxins10100413.|||30322120|||Toxins (Basel). 2018;10(10):413. doi:10.3390/toxins10100413. PubMed|||30322120|||Toxins (Basel) . 2018 Oct 13;10(10):413. doi: 10.3390/toxins10100413.|||Toxins (Basel). 2018;10(10):413. doi:10.3390/toxins10100413. PubMed" 24 FPDB01094 AP03179|||AP03179|||Brevinin-1GHd, Brevinin-1HL|||Brevinin-1GHd, Brevinin-1HL|||AP03179|||DRAMP29052 " FLGALFKVASKLVPAAICSISKKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-inflammatory||anti-sepsis||Anti-S. aureus or MRSA, activity value is MIC = 2||Anti-E. coli, activity value is MIC = 8 uM||Anti-P. aeruginosa, activity value is MIC = 32 uM||Anti-C. albicans, activity value is MIC = 4 uM||Antibacterial||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 2 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 4 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MIC = 4 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MBC = 4 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 8 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 32 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 32 uM||Anti-Candida albicans NCPE 1467, activity value is MIC = 4 uM||Anti-Candida albicans NCPE 1467, activity value is MBC = 8 uM||Anti-Human squamous lung carcinoma NCI-H157, activity value is IC50 = 2.987 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 7.985 uM||Anti-Human breast adenocarcinoma MDA-MB-435S, activity value is IC50 = 1.197 uM||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 9.854 uM||Anti-Chromobacterium violaceum ATCC 12472, activity value is MIC = 205.2 uM||Anti-Chromobacterium violaceum ATCC 12472, activity value is MBC = 205.2 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC = 51.3 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MBC = 205.2 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MIC = 12.8 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MBC = 205.2 uM||Anti-Human lung adenocarcinoma NCI-H23, activity value is IC50 = 8.52||Anti-S. aureus, activity value is MIC = 2 uM||Anti-MRSA, activity value is MIC = 4 uM||Anti-##Gram-negative: E. coli, activity value is MIC = 8 uM||Anti-##Fungi: C. albicans, activity value is MIC = 4 uM Hoplobatrachus rugulosus , China, Asia; skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia|||Sylvirana guentheri (Hylarana guentheri),Hylarana latouchii|||Sylvirana guentheri (Hylarana guentheri),Hylarana latouchii|||Hoplobatrachus rugulosus , China, Asia; skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia|||Sylvirana guentheri (Gunther's frog) (Rana guentheri)|||Hoplobatrachus rugulosus , China, Asia; skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia Helix||α-helical "In this document, the key values related to hemolysis for the novel antimicrobial peptide Brevinin-1GHa derived from the skin of the swamp frog (Hylarana guentheri) and its analogs Brevinin-1GHb and Brevinin-1GHc are as follows, determined by a horse red blood cell hemolysis assay (with 2% Triton X-100 as the 100% hemolysis positive control and PBS as the 0% hemolysis negative control): Core Hemolytic Activity Results - Test concentration range: 1–512 µM (covering the effective antimicrobial concentrations of the three peptides, with Brevinin-1GHa having an MIC against S. aureus of 2 µM, Brevinin-1GHb showing only weak activity against S. aureus with an MIC of 512 µM, and Brevinin-1GHc having an MIC against S. aureus of 16 µM) - Hemolysis values of each peptide: - Brevinin-1GHa (natural peptide containing a C-terminal Rana-box): - At a concentration of 16 µM, the hemolysis rate is close to 20%; - Its effective antimicrobial concentrations (e.g., MIC against S. aureus = 2 µM, MIC against C. albicans = 2 µM) are much lower than the concentration at which significant hemolysis occurs, indicating a low risk of hemolysis during antimicrobial activity, though there is still some hemolytic toxicity at higher concentrations. - Brevinin-1GHb (truncated peptide lacking the Rana-box): - Only at a concentration of 512 µM does the hemolysis rate approach 20%; - This concentration is far higher than its sole antimicrobial active concentration (MIC against S. aureus = 512 µM), and it has no antimicrobial activity against other tested strains, indicating extremely low hemolytic toxicity but weak antimicrobial activity. - Brevinin-1GHc (modified peptide with the Rana-box transferred to the central region): - At a concentration of 128 µM, the hemolysis rate approaches 20%; - Its effective antimicrobial concentration (e.g., MIC against S. aureus = 16 µM) is lower than the concentration at which significant hemolysis occurs, and its hemolytic activity is significantly lower than that of the natural peptide Brevinin-1GHa, although its antimicrobial activity is also slightly reduced compared to the natural peptide.|||At the highest MIC concentration (32 µM against Pseudomonas aeruginosa), the hemolysis rate of horse red blood cells was 13%; when the concentration was higher than 64 µM, the hemolysis rate gradually increased.|||Hoplobatrachus rugulosus , China, Asia; skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia||Brevinin-1GHd shows 13% hemolysis at its highest MIC/MBC values|||Human microvascular endothelial cells HMEC-1 (50% Cell death at 15.62 uM, Human keratinocytes HaCat (50% Cell death at 29.69 uM|||Human microvascular endothelial cells HMEC-1 (50% Cell death at 15.62 uM, Human keratinocytes HaCat (50% Cell death at 29.69 uM|||Brevinin-1GHd shows 13% hemolysis at its highest MIC/MBC values|||[Ref.32347293] Brevinin-1GHd displayed 13% hemolysis on horse red blood cells at its highest MIC/MBC value of the tested bacteria P. aeruginosa (32 uM). However, when the concentration increased above 64 uM, the hemolytic activity of Brevinin-1GHd also gradually increased. At the concentration of 64, 128, 256 and 512 uM, it displayed about 36%, 64%, 83% and 108% hemolysis.|||Brevinin-1GHd displayed 13% hemolysis at its highest MIC/MBC value, indicating Brevinin-1GHd exhibited low hemolytic activity on horse red blood cells (Figure 6A). However, when the concentration increased above 64 uM, the hemolytic activity of Brevinin-1GHd also gradually increased." "Biosci Rep . 2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.|||2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.|||Biosci Rep . 2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.|||32347293|||32347293|||Biosci Rep . 2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.|||Biosci Rep. 2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.||Ref.32347293|||Biosci Rep. 2020;BSR20200019. doi:10.1042/BSR20200019. PubMed" 24 FPDB01096 AP03185|||AP03185|||Dermaseptin-AC4, DRP-AC4|||Dermaseptin-AC4, DRP-AC4|||AP03185 SLWGKLKEMAAAAGKAALNAVNGLVNQ Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anti-E. coli, activity value is MIC = 8 uM||Anti-C. albicans, activity value is MIC = 64 uM||Anti-E. faecalis, activity value is MIC = 32 uM||Anti-K. pneumoniae, activity value is MIC = 32 uM||Anti-and MRSA, activity value is MIC = 32 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 8 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 32 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 8 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 8 uM||Anti-Candida albicans NCTC 1467, activity value is MIC = 64 uM||Anti-Candida albicans NCTC 1467, activity value is MBC = 128 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 64 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 128 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MIC = 32 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MBC = 64 uM||Anti-Klebsiella pneumoniae ATCC 43816, activity value is MIC = 32 uM||Anti-Klebsiella pneumoniae ATCC 43816, activity value is MBC = 32 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MIC = 32 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MBC = 64 uM Skin Secretion, the Red-Eyed Tree Frog, Agalychnis callidryas, North America (Mexico) to Central America|||Synthetic construct|||Agalychnis callidryas|||Skin Secretion, the Red-Eyed Tree Frog, Agalychnis callidryas, North America (Mexico) to Central America|||Skin Secretion, the Red-Eyed Tree Frog, Agalychnis callidryas, North America (Mexico) to Central America Helix "In this document, the key values related to hemolysis for the novel antimicrobial peptide Dermaseptin-AC (DRP-AC4) derived from the skin of the red-eyed tree frog (Agalychnis callidryas) and its modified peptides DRP-AC4a and DRP-AC4b are as follows, measured by the horse red blood cell hemolysis assay (using 1% Triton X-100 as 100% hemolysis positive control and PBS as 0% hemolysis negative control): Core Hemolytic Activity Results - Test concentration range: 1–512 μM (covering the effective antimicrobial concentrations of the three peptides, e.g., the MIC of DRP-AC4a against MRSA is 8 μM, and against Candida albicans is 16 μM) - Hemolysis values of each peptide: - Hemolysis rate at antimicrobial effective concentrations: At the geometric mean MIC (GM MIC) concentrations against seven test strains, the hemolysis rate of the three peptides is approximately 10%, with the corresponding concentrations and hemolysis as follows: - DRP-AC4 (natural peptide): GM MIC = 26.25 μM, hemolysis rate at this concentration is about 10%; - DRP-AC4a (modified peptide with enhanced cationicity and amphipathicity): GM MIC = 14.49 μM, hemolysis rate at this concentration is slightly below 10%, the lowest among the three peptides; - DRP-AC4b (modified peptide optimized for amphipathic structure): GM MIC = 21.53 μM, hemolysis rate at this concentration is about 10%. - Hemolysis trend at high concentrations: The document does not specify the exact hemolysis values at high concentrations (such as 128 μM, 256 μM, 512 μM), but it clearly states that the hemolytic activity of all peptides is lower than their antimicrobial activity, and the hemolytic toxicity is low at effective antimicrobial concentrations.|||Skin Secretion, the Red-Eyed Tree Frog, Agalychnis callidryas, North America (Mexico) to Central America|||Horse erythrocytes (10% Hemolysis at 26.5 uM|||The documentation provides hemolytic data on equine erythrocytes for DRP-AC4 and its two analogs (DRP-AC4a, DRP-AC4b), with the following core information: 1. Critical hemolytic value (for equine red blood cells) Common features: The three peptides showed similar low hemolytic activity at their respective minimum inhibitory concentrations (MIC) against seven species of bacteria, with a hemolysis rate of about 10%. Details by peptide classification: DRP-AC4: Under the geometric mean MIC(GM MIC = 26.25 uM) concentration, the hemolysis rate is about 10%. With the increase of concentration, the hemolysis rate gradually increases (for example, when the concentration reaches 70 uM, the hemolysis rate is close to 40%). DRP-AC4a: At its geometric mean MIC(GM MIC = 14.49 uM) concentration, the hemolysis rate was slightly lower than that of the other two peptides (still close to 10%); when the concentration was increased to 70 uM, the hemolysis rate was about 35%, and the overall hemolysis activity was slightly weaker than that of the parent peptide. DRP-AC4b: At the geometric mean MIC(GM MIC = 21.53 uM) concentration, the hemolysis rate was about 10%. When the concentration reached 70 uM, the hemolysis rate was close to 40%, which was consistent with the DRP-AC4 trend. 2. Additional Notes Experimental control: PBS was used as negative control (no hemolysis),1% Triton X-100 was used as positive control (complete hemolysis), and the hemolysis rate was calculated by detecting the absorbance at 550 nm. The impact of structural modification on hemolysis: DRP-AC4a (increasing net charge to +4, optimizing amphiphilicity) enhanced the antibacterial activity, but did not significantly improve the hemolysis rate, and the hemolysis activity was even slightly lower at GM MIC concentration, indicating that a reasonable increase in positive charge can maintain low cytotoxicity while enhancing the antibacterial activity. The DRP-AC4b (optimized hydrophobic surface, net charge is still +3) is consistent with the hemolysis trend of the parent peptide DRP-AC4, indicating that the integrity of the hydrophobic surface does not significantly change the hemolysis activity in the case of similar hydrophobic degree.|||Horse erythrocytes (10% Hemolysis at 26.5 uM" "Antibiotics (Basel) . 2020 May 10;9(5):243. doi: 10.3390/antibiotics9050243.|||Antibiotics (Basel) . 2020 May 10;9(5):243. doi: 10.3390/antibiotics9050243.|||32397600|||Antibiotics (Basel). 2020;9(5):E243. doi:10.3390/antibiotics9050243. PubMed|||32397600|||Antibiotics (Basel) . 2020 May 10;9(5):243. doi: 10.3390/antibiotics9050243.|||Antibiotics (Basel). 2020;9(5):E243. doi:10.3390/antibiotics9050243. PubMed" 27 FPDB01098 AP03225|||AP03225|||Ranatuerin-2Pb|||DRAMP21334|||Ranatuerin-2Pb|||AP03225|||DRAMP21334 " SFLTTVKKLVTNLAALAGTVIDTIKCKVTGGCRT" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Anti-S. aureus, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 8 uM||Anti-MRSA, activity value is MIC = 16 uM||Anti-and C. albicans, activity value is MIC = 8 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 8 uM||Anti-Enterococcus faecalis, activity value is MIC > 256 uM||activity value is MBC > 256 uM||Anti-Escherichia coli, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa, activity value is MIC > 256 uM||Anti-Candida albicans, activity value is MIC = 8 uM||activity value is MBC = 8 uM||activity value is MBC = 16 uM||activity value is MBC = 32 uM||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC = 8 uM||Anti-##Fungi: Candida albicans, activity value is MIC = 8 uM Skin Secretion, Northern leopard frog, Rana pipiens, North America|||Rana pipiens|||Lithobates pipiens (Northern leopard frog) (Rana pipiens)|||Rana pipiens|||Skin Secretion, Northern leopard frog, Rana pipiens, North America|||Lithobates pipiens (Northern leopard frog) (Rana pipiens)|||Skin Secretion, Northern leopard frog, Rana pipiens, North America Helix||50% Helix, 7.8% antiparallel, 1.2% parallel, 10.9% turn and 29.8% others in 50% TFE/H2O. ##3.5% Helix, 26.6% antiparallel, 0% parallel, 18.3% turn and "In this document, the key values related to hemolysis for the antimicrobial peptide Ranatuerin-2Pb derived from the skin of the Northern Leopard Frog (Rana pipiens) and its truncated analogs RPa and RPb are as follows, measured using a horse red blood cell hemolysis assay (with 1% Triton X-100 as 100% hemolysis positive control and PBS as 0% hemolysis negative control): Core Hemolytic Activity Results - Test concentration range: 1–256 μM (covering the antibacterial effective concentrations of the three peptides, e.g., the MIC of Ranatuerin-2Pb against S. aureus is 8 μM, and the MIC of RPb against MRSA is 16 μM) - Hemolysis values for each peptide: 1. Ranatuerin-2Pb (natural peptide): - Concentration corresponding to 20% hemolysis: at 8 μM concentration, hemolysis is close to 20%; - Half-maximal hemolysis concentration (HC₅₀): 16.11 μM, with antibacterial effective concentrations (e.g., MIC against S. aureus = 8 μM) close to the hemolytic activity concentration, resulting in a low therapeutic index (TI = HC₅₀/geometric mean MIC) of only 0.449. 2. RPa (truncated peptide missing 2 residues at the C terminus): - Concentration corresponding to 20% hemolysis: at 32 μM concentration, hemolysis is close to 20%; - HC₅₀: 63.9 μM, hemolytic activity significantly lower than the natural peptide, with a slightly higher therapeutic index than the natural peptide (TI = 0.353), but antibacterial activity somewhat reduced (MIC against S. aureus = 16 μM). 3. RPb (N-terminal 16-residue truncated and C-terminal amidated analog): - Concentration corresponding to 20% hemolysis: at 64 μM concentration, hemolysis is close to 20%; - HC₅₀: 178 μM, the lowest hemolytic activity among the three peptides, with the highest therapeutic index (TI = 8.83), and the broadest antibacterial spectrum (active against both MRSA and P. aeruginosa), showing a significant safety advantage.|||Skin Secretion, Northern leopard frog, Rana pipiens, North America||Ranatuerin-2 Pb, RPa, and RPb showed nearly 20% hemolysis on horse red blood cells at concentrations of 8, 32, and 64 μM, respectively|||Horse blood cells (50% hemolysis at 16.11 uM)|||- Ranatuerin-2Pb: - Hemolysis rate is about 20% at 8 µM; - Half-maximal hemolytic concentration (HC_{50}) is 16.11 µM. - RPa: - Hemolysis rate is about 20% at 32 µM; - Half-maximal hemolytic concentration (HC_{50}) is 63.9 µM. - RPb: - Hemolysis rate is about 20% at 64 µM; - Half-maximal hemolytic concentration (HC_{50}) is 178 µM (lowest hemolytic activity, best safety).|||Horse blood cells (50% hemolysis at 16.11 uM)|||Ranatuerin-2 Pb, RPa, and RPb showed nearly 20% hemolysis on horse red blood cells at concentrations of 8, 32, and 64 μM, respectively|||[Ref.31242693] 7% hemolysis at 2 uM, 23% hemolysis at 8 uM, 50% hemolysis at 16 uM, 71% hemolysis at 32 uM, 100% hemolysis at 64 uM on horse erythrocytes.|||Ranatuerin-2Pb, RPa andRPb exhibited a hemolysis rate near 20% on horse erythrocytes with the concentration at 8,32 and 64 uM,respectively,as shown in Figure4." "Biomolecules . 2019 Jun 25;9(6):249. doi: 10.3390/biom9060249.|||Biomolecules . 2019 Jun 25;9(6):249. doi: 10.3390/biom9060249.|||31242693|||Biomolecules. 2019 Jun 25;9(6):249. doi: 10.3390/biom9060249.||Ref.31242693|||31242693|||Biomolecules . 2019 Jun 25;9(6):249. doi: 10.3390/biom9060249.|||Biomolecules. 2019 Jun 25;9(6):249. doi: 10.3390/biom9060249.||Ref.31242693|||Biomolecules. 2019 Jun 25;9(6):249. doi: 10.3390/biom9060249. PubMed" 34 FPDB01101 AP03240|||AP03240|||Brevinin-1H|||Brevinin-1H|||AP03240|||DRAMP32300 " FALGAVTKVLPKLFCLITRKC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Antibiofilm||Anti-Gram+ S. aureus, activity value is MIC = 4 uM||Anti-MRSA, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 16 uM||Anti-P. aeruginosa, activity value is MIC = 64 uM||Anti-K. pneumoniae, activity value is MIC = 64 uM||Anti-and yeast C. albicans, activity value is MIC = 16 uM||Anti-MB435S and HCT116 human cancer cell lines, activity value is IC50 = 3.4||Antibacterial||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 4 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 8 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 16 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 32 uM||Anti-Candida albicans NCTC 1467, activity value is MIC = 16 uM||Anti-Candida albicans NCTC 1467, activity value is MFC = 16 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 64 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 128 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MIC = 8 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MBC = 16 uM||Anti-Klebsiella pneumoniae ATCC 43816, activity value is MIC = 64 uM||Anti-Klebsiella pneumoniae ATCC 43816, activity value is MBC = 64 uM||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 5.87 uM||Anti-Human breast adenocarcinoma MDA-MB-435S, activity value is IC50 = 3.47 uM||Anti-Human squamous lung carcinoma NCI-H157, activity value is IC50 = 3.37 uM||Anti-Human colon adenocarcinoma HCT 116, activity value is IC50 = 2.599 uM||Antimicrobial||Anticancer skin secretions, Hainan cascade-frog, Amolops hainanensis; China, Asia|||Amolops hainanensis|||skin secretion of Amolops hainanensis|||skin secretion of Amolops hainanensis|||skin secretions, Hainan cascade-frog, Amolops hainanensis; China, Asia N/A "In this document, the key values related to hemolysis of the novel antimicrobial peptide Brevinin-1H derived from the skin of Hainan torrent frog (Amolops hainanensis) and its modified analogs Brevinin-1Ha and Brevinin-1HY are as follows, determined by a horse red blood cell hemolysis assay (using 1% Triton X-100 as 100% hemolysis positive control and PBS as 0% hemolysis negative control): Core Hemolytic Activity Results - Test concentration range: 1–512 μM (covering the antimicrobial effective concentrations of the three peptides, e.g., MIC of Brevinin-1H against S. aureus = 4 μM, MRSA MIC = 8 μM) - Hemolysis values of each peptide: 1. Brevinin-1H (natural peptide): - Concentration corresponding to 20% hemolysis: At 32 μM, hemolysis was 22.1%, which is close to its effective antimicrobial concentration against some pathogens (e.g., MIC against E. coli = 16 μM); - Half-maximal hemolytic concentration (HC₅₀): 53.12 μM, therapeutic index (TI = HC₅₀/geometric mean MIC) is low; safety needs improvement. 2. Brevinin-1Ha (modified peptide with Rana-box moved to the center): - Concentration corresponding to 20% hemolysis: Hemolysis only reached 9.49% at 128 μM, not reaching 20%; - HC₅₀: 437.2 μM, the lowest hemolytic activity among the three peptides, significantly reducing hemolytic toxicity, but the antimicrobial activity is almost entirely lost (only weak activity against E. coli, MIC = 64 μM). 3. Brevinin-1HY (modified peptide with Pro¹¹ replaced by Tyr): - Concentration corresponding to 20% hemolysis: At its MIC against S. aureus = 4 μM, hemolysis was already 28.48%, much higher than that of the natural peptide at the same concentration; - HC₅₀: The exact value is not explicitly provided in the document, but according to the hemolysis curve trend, its HC₅₀ is significantly lower than that of the natural peptide (<53.12 μM), with substantially increased hemolytic toxicity. Although antimicrobial activity (against Gram-positive bacteria) and anticancer activity are slightly improved, safety is decreased.|||skin secretions, Hainan cascade-frog, Amolops hainanensis; China, Asia|||Horse erythrocytes (9.49% Hemolysis at 4 uM|||The document clearly provides hemolytic data for natural antimicrobial peptide Brevinin-1H and its two structural analogs (Brevinin-1Ha, Brevinin-1HY) on 2% horse erythrocyte suspension. The experiment used 1% Triton X-100 as the fully hemolytic positive control (hemolysis rate = 100%) and PBS as the negative control (hemolysis rate = 0%). The core information is as follows: 1. Brevinin-1H Half-hemolytic concentration (HC₅₀): 53.12 uM. Hemolysis rate at critical concentrations: At 32 μM, the hemolysis rate exceeds 20% (specifically 22.1%); Its resistance to Staphylococcus aureus (S. aureus) has a minimum inhibitory concentration (MIC) of 4 μM, at which the hemolysis rate is relatively low (exact value unclear, but significantly below 20%). 2. Brevinin-1Ha Half hemolytic concentration (HC₅₀): 437.2 uM, with hemolytic activity significantly lower than natural peptides. Hemolysis rate at key concentrations: at 128 μM, the hemolysis rate only exceeds 20% (specifically above 9.49%, not fully quantified, but significantly lower than natural peptides); At low concentrations (e.g., ≤64 μM), the hemolysis rate is extremely low, close to 0%. 3. Brevinin-1HY Half hemolytic concentration (HC₅₀): No direct value is clear, but overall hemolytic activity is significantly higher than that of the natural peptide Brevinin-1H. Hemolysis rate at key concentrations: its MIC for resistance to Staphylococcus aureus (S. aureus) is 4 uM, and at this concentration, the hemolysis rate reaches 28.48%, more than three times that of the natural peptide Brevinin-1H at MIC. The association between hemolysis and biological activity Although Brevinin-1H has broad-spectrum antibacterial activity (against Gram-positive bacteria, Gram-negative bacteria, fungi) and cancer resistance, it has relatively high hemolysis, with hemolysis exceeding 20% at 32 μM concentration, requiring further optimization to reduce toxicity. Brevinin-1Ha significantly reduces hemolytic activity by transferring the Rana-box from the C-terminal to the central position (HC₅₀ from 53.12 uM to 437.2 uM), but its antibacterial and anticancer activity is almost lost, with only weak activity against E. coli, and anticancer requires a high concentration of 10⁻⁴ M. After replacing Pro¹¹ with tyrosine in Brevinin-1HY, the α-helix ratio increased from 52% to 67%, enhancing anti-proliferative activity against some cancer cells, but hemolysis was greatly increased, with a hemolysis rate of 28.48% under MIC and reduced safety.|||Horse erythrocytes (9.49% Hemolysis at 4 uM|||Lee and coworkers substituted Glu9 with Pro producing a helix-kink-helix structure in Anal 3-Pro peptide, which apparently increased antibacterial activity of parent peptide with no hemolysis (Lee et al., 2013)." "Chem Biol Drug Des . 2021 Feb;97(2):273-282. doi: 10.1111/cbdd.13779. Epub 2020 Sep 7.|||Chem Biol Drug Des . 2021 Feb;97(2):273-282. doi: 10.1111/cbdd.13779. Epub 2020 Sep 7.|||32812694|||Chem Biol Drug Des. 2021 Feb;97(2):273-282. doi: 10.1111/cbdd.13779. PubMed|||32812694|||Chem Biol Drug Des . 2021 Feb;97(2):273-282. doi: 10.1111/cbdd.13779. Epub 2020 Sep 7.|||Chem Biol Drug Des. 2021 Feb;97(2):273-282.|||Chem Biol Drug Des. 2021 Feb;97(2):273-282. doi: 10.1111/cbdd.13779. PubMed" 21 FPDB01107 AP03274 " HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli, activity value is MIC = 28.3 uM||Anti-S.aureus, activity value is MIC > 30 uM||Anti-P. aeruginosa, activity value is MIC = 1.2 uM||Anti-and B. cereus, activity value is MIC = 23.3||Anti-A. pleuropneumoniae, activity value is MIC = 7.5 ug/ml||Anti-B. subtilis, activity value is MIC = 28 ug/ml||Anti-B. velezensis, activity value is MIC = 76 ug/ml||Anti-B. amyloliquefaciens, activity value is MIC = 42 ug/ml||Anti-inactive against P.putida, activity value is MIC = 113 ug/ml||Anti-S.aureus, activity value is MIC > 200 ug/ml||Anti-and P. aeruginosa PAO1, activity value is MBC = 2 brain, kidney, Homo sapiens|||brain, kidney, Homo sapiens Helix "In this document, the key values related to hemolysis of pituitary adenylate cyclase-activating polypeptide (PACAP) and its analogs are as follows, measured by human red blood cell hemolysis experiments (with 10% Triton X-100 as 100% hemolysis positive control and PBS as 0% hemolysis negative control): Core Hemolytic Activity Results - Test concentration range: 1–30 μM (covering the antimicrobial effective concentrations of PACAP38 and its analogs, e.g., PACAP38 MIC against Pseudomonas aeruginosa = 1.2 μM, MIC against Escherichia coli = 0.76 μM) - Hemolysis values of each peptide: 1. PACAP38 (natural peptide): Low hemolytic toxicity; at 30 μM, the hemolysis rate is <0.2 (Figure 2B), far lower than the control antimicrobial peptides—natural peptide indolicidin (≈0.8 at 30 μM) and synthetic peptide ARVA (≈0.6 at 30 μM), indicating high safety for human red blood cells while exerting antimicrobial effects. 2. PACAP38 receptor agonist analogs: - [D-Ser²]PACAP38, [Iac¹]PACAP38, [Iaa¹]PACAP38, [Pro³]PACAP38: Hemolytic activity similar to PACAP38, with hemolysis rate <0.2 at 30 μM (Figure 2A), showing no significant hemolytic toxicity; - [Lys³⁸-palmitoyl]PACAP38: Hemolytic toxicity significantly increased, hemolysis rate ≈0.8 at 30 μM (Figure 2B), comparable to indolicidin, suggesting palmitoyl modification enhances hydrophobic interaction with red blood cell membranes; - [Iaa¹,D-Ser²,Ala¹⁶,¹⁷,²²,D-Lys³⁸]PACAP38: Hemolysis rate <0.2 at 30 μM, maintaining low hemolytic properties. 3. PACAP38 receptor antagonist analogs: - [Sar⁴]PACAP38, PACAP(6-38): Hemolytic activity consistent with PACAP38, hemolysis rate <0.2 at 30 μM, without additional hemolytic risk. 4. PACAP38 analogs with piperidine carboxyl modifications: - e.g., [Pip³]PACAP38, [N-acetyl-His¹,Pip³]PACAP38, etc.: Hemolysis rate <0.2 at 30 μM, low hemolytic properties unchanged by modification.|||brain, kidney, Homo sapiens||Regarding hemolytic activity, moderate activity was reported for 19 TsAP-2 and microperforin, with hemolysis observed at concentrations of approximately 20 µM. In 20 cases of Im-4 and Im-6, no significant hemolysis was observed even at concentrations of 30, 21, and 25 µM, respectively. Although the types of red blood cells used in this study were different from the 22 red blood cell types for TsAP-2 and microperforin, the hemolytic activity of Im-4 and Im-6 may be lower than that of TsAP-2 and microperforin.|||Regarding hemolytic activity, moderate activity was reported for 19 TsAP-2 and microperforin, with hemolysis observed at concentrations of approximately 20 µM. In 20 cases of Im-4 and Im-6, no significant hemolysis was observed even at concentrations of 30, 21, and 25 µM, respectively. Although the types of red blood cells used in this study were different from the 22 red blood cell types for TsAP-2 and microperforin, the hemolytic activity of Im-4 and Im-6 may be lower than that of TsAP-2 and microperforin." "Peptides . 2018 Jun:104:35-40. doi: 10.1016/j.peptides.2018.04.006. Epub 2018 Apr 11.|||Peptides . 2018 Jun:104:35-40. doi: 10.1016/j.peptides.2018.04.006. Epub 2018 Apr 11||PMID:30462698||PMID: 33372152||see ref|||Peptides. 2018 Jun;104:35-40. doi: 10.1016/j.peptides.2018.04.006. PubMed" 38 FPDB01109 AP03310 GFGCNLITSNPYQCSNHCKSVGYRGGYCKLRTVCTCY Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Anti-and C. difficile DPC6534 . Also tested using MRSA, activity value is MIC = 23 ug/ml||Anti-P.aeruginosa, activity value is MIC = 1448 ug/ml Actinomyces ruminicola Bridge Actinomyces ruminicola "J Bacteriol. 202:e00529-19. Online PDF|||J Bacteriol . 2020 Jan 29;202(4):e00529-19. doi: 10.1128/JB.00529-19. Print 2020 Jan 29.|||J Bacteriol. 202:e00529-19. Online PDF" 37 FPDB01124 AP03333|||AP03333|||OaBac7.5mini|||OaBac7.5mini|||AP03333 " RRIPRPILLPWRPPRPIPRPQPQPIPRWL" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-rough K-12 strain, activity value is MIC = 8||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 32 ug/ml||Anti-defensin supersusceptible, activity value is MIC = 2 ug/ml||Anti-antibiotic-supersusceptible mutant, activity value is MIC = 16||Anti-S. aureus NCTC 4163 or MRSA R147, activity value is MIC = 32||Anti-S. epidermidis clinical isolate, activity value is MIC = 32 ug/ml||Anti-E. faecalis ATCC 29212, activity value is MIC = 64 ug/ml||Anti-and yeast . C. albicans 105 or 3153A, activity value is MIC = 64 ug/ml||Anti-Escherichia coli O111, activity value is MIC = 16 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 8 ug/ml||Anti-Escherichia coli DC2, activity value is MIC = 2 ug/ml||Anti-Escherichia coli O157:H7, activity value is MIC = 32 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s, activity value is MIC = 32 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS4252S, activity value is MIC = 2 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus NCTC 4163, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus R147, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus 1056, activity value is MIC > 64 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 32 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 64 ug/ml||Anti-Candida albicans 105, activity value is MIC = 64 ug/ml||Anti-Candida albicans 3153A, activity value is MIC > 64 ug/ml sheep; Ovis aries|||Synthetic construct|||Synthetic construct|||sheep; Ovis aries|||sheep; Ovis aries Rich sheep; Ovis aries "Comparative Study Biochem Biophys Res Commun . 2003 Dec 26;312(4):1139-46. doi: 10.1016/j.bbrc.2003.11.045.|||Antimicrob Agents Chemother . 2004 Feb;48(2):673-6. doi: 10.1128/AAC.48.2.673-676.2004.|||14742236|||14742236|||Antimicrob Agents Chemother . 2004 Feb;48(2):673-6. doi: 10.1128/AAC.48.2.673-676.2004.|||Biochem Biophys Res Commun. 2003 Dec 26;312(4):1139-46. doi: 10.1016/j.bbrc.2003.11.045. PubMed" 29 FPDB01125 AP03334|||AP03334|||OaBac5mini|||OaBac5mini|||AP03334 " RFRPPIRRPPIRPPFRPPFRPPVR" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-ATCC25922, activity value is MIC = 2||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 0.5 ug/ml||Anti-defensin supersusceptible, activity value is MIC = 0.125||Anti-61, activity value is MIC = 4||Anti-S. aureus NCTC 4163 or MRSA R147 or 1056 MRSA, activity value is MIC = 16||Anti-S. epidermidis clinical isolate, activity value is MIC = 16 ug/ml||Anti-E. faecalis ATCC 29212, activity value is MIC = 32 ug/ml||Anti-and yeast C. albicans 105 or 3153A, activity value is MIC = 32||Antibacterial||Anti-Escherichia coli O111, activity value is MIC = 2 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 0.125 ug/ml||Anti-Escherichia coli DC2, activity value is MIC = 0.125 ug/ml||Anti-Escherichia coli O157:H7, activity value is MIC = 8 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s, activity value is MIC = 0.5 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS4252S, activity value is MIC = 0.125 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus NCTC 4163, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus R147, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus 1056, activity value is MIC = 16 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 16 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 32 ug/ml||Anti-Candida albicans 105, activity value is MIC = 32 ug/ml||Anti-Candida albicans 3153A, activity value is MIC = 16 ug/ml||Anti-Escherichia coli O157:H7, activity value is MIC = 16.3 ug/ml||Anti-Staphylococcus aureus 1056, activity value is MIC = 26 ug/ml truncated fragment|||Synthetic construct|||Synthetic construct|||truncated fragment Rich truncated fragment|||Escherichia coli O111[MIC = 2 ug/ml], Escherichia coli UB1005[MIC = 0.125 ug/ml], Escherichia coli DC2[MIC = 0.125 ug/ml], Escherichia coli O157:H7[MIC = 8 ug/ml], Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s[MIC = 0.5 ug/ml], Salmonella enterica serovar Typhimurium MS4252S[MIC = 0.125 ug/ml], Pseudomonas aeruginosa PAO1[MIC = 4 ug/ml], Pseudomonas aeruginosa Z61[MIC = 8 ug/ml], Staphylococcus aureus NCTC 4163[MIC = 32 ug/ml], Staphylococcus aureus R147[MIC = 64 ug/ml], Staphylococcus aureus 1056[MIC = 16 ug/ml], Staphylococcus epidermidis[MIC = 16 ug/ml], Enterococcus faecalis ATCC 29212[MIC = 32 ug/ml], Candida albicans 105[MIC = 32 ug/ml], Candida albicans 3153A[MIC = 16 ug/ml], Escherichia coli O157:H7[MIC = 16.3 ug/ml], Staphylococcus aureus 1056[MIC = 26 ug/ml] "Antimicrob Agents Chemother . 2004 Feb;48(2):673-6. doi: 10.1128/AAC.48.2.673-676.2004.|||Antimicrob Agents Chemother . 2004 Feb;48(2):673-6. doi: 10.1128/AAC.48.2.673-676.2004.|||14742236, 19396584|||14742236, 19396584|||Antimicrob Agents Chemother . 2004 Feb;48(2):673-6. doi: 10.1128/AAC.48.2.673-676.2004.|||Antimicrob Agents Chemother. 2004 Feb;48(2):673-6. doi: 10.1128/AAC.48.2.673-676.2004. PubMed" 24 FPDB01126 AP03335|||AP03335|||Checacin1|||Checacin1|||AP03335 " FFGAIAKLAMKFLPAIYKQIQKKRK" Anti-Gram+ & Gram-||Antifungal||candidacidal||Insecticidal||Anti-MRSA||Anti-E. coli ATCC 35218, activity value is MIC = 0.8||Anti-P. aeruginosa ATCC27853, activity value is MIC = 12.5||Anti-M. smegmatis, activity value is MIC = 25||Anti-S. aureus ATCC33592, activity value is MIC = 1.6 uM||Anti-A. flavus, activity value is MIC = 50||Anti-C. albicans, activity value is MIC = 6.25 uM||Anti-Escherichia coli ATCC 35218 TEM-1 beta-lactamase expressing strain, activity value is MIC = 1.6||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 12.5 uM||Anti-Mycobacterium smegmatis ATCC 607, activity value is MIC = 25 uM||Anti-Staphylococcus aureus ATCC 33592, activity value is MIC = 1.6 uM||Anti-Aspergillus flavus ATCC 9170, activity value is MIC = 50 uM||Anti-Candida albicans FH 2173, activity value is MIC = 6.2 uM venom, Chelifer cancroides, Europe.|||Chelifer cancroides [Pseudoscorpion]|||Chelifer cancroides [Pseudoscorpion]|||venom, Chelifer cancroides.|||venom, Chelifer cancroides, Europe N/A venom, Chelifer cancroides.||At MIC dose concentrations (4-16 µg/ml), it exhibits hemolytic activity (>5%) on human RBCs. As the concentration of this antimicrobial peptide increases, the percentage of hemolysis increases. At the highest concentration (128 µg/ml), it shows 17% hemolytic activity.|||At MIC dose concentrations (4-16 µg/ml), it exhibits hemolytic activity (>5%) on human RBCs. As the concentration of this antimicrobial peptide increases, the percentage of hemolysis increases. At the highest concentration (128 µg/ml), it shows 17% hemolytic activity. "Toxins (Basel) . 2022 Jan 14;14(1):58. doi: 10.3390/toxins14010058.|||Toxins (Basel) . 2022 Jan 14;14(1):58. doi: 10.3390/toxins14010058.|||35051034|||35051034|||Toxins (Basel) . 2022 Jan 14;14(1):58. doi: 10.3390/toxins14010058.|||Toxins (Basel). 2022 Jan 14;14(1):58. doi: 10.3390/toxins14010058. PubMed" 25 FPDB01131 AP03426|||AP03426|||Dermaseptin-PS1|||Dermaseptin-PS1|||AP03426 GLWKSLFKNVGKAAGKAALNAVTDMVNQ Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anti-S. aureus NCTC 10788, activity value is MIC = 16 ug/ml||Anti-MRSA NCTC 12493, activity value is MIC = 64 ug/ml||Anti-MRSA, activity value is MIC = 32 ug/ml||Anti-C. albicans NCYC 1467, activity value is MIC = 32 ug/ml||Anti-E. coli, activity value is MIC = 16 ug/ml||Anti-and P. aeruginosa, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 32 ug/ml||Anti-Staphylococcus aureus NCTC 12493, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus NCTC 12493, activity value is MBC = 128 ug/ml||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus ATCC 43300, activity value is MBC = 64 ug/ml||Anti-Escherichia coli NCTC 10418, activity value is MIC = 16 ug/ml||Anti-Escherichia coli NCTC 10418, activity value is MBC = 16 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 64 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 128 ug/ml||Anti-Candida albicans NCYC 1467, activity value is MIC = 32 ug/ml||Anti-Candida albicans NCYC 1467, activity value is MFC = 32 ug/ml Skin secretion, the waxy monkey leaf frog or waxy monkey tree frog, Phyllomedusa sauvagei, Argentina, Bolivia, Paraguay and Brazil, South America|||Phyllomedusa sauvagii|||Phyllomedusa sauvagii|||Skin secretion, the waxy monkey leaf frog or waxy monkey tree frog, Phyllomedusa sauvagei, Argentina, Bolivia, Paraguay and Brazil, South America|||Skin secretion, the waxy monkey leaf frog or waxy monkey tree frog, Phyllomedusa sauvagei, Argentina, Bolivia, Paraguay and Brazil, South America N/A "Skin secretion, the waxy monkey leaf frog or waxy monkey tree frog, Phyllomedusa sauvagei, Argentina, Bolivia, Paraguay and Brazil, South America|||Mouse erythrocytes (50% Hemolysis at >512 ug/ml|||The core hemolytic data for two novel dermaseptin peptides (DMS-PS1 and DMS-PS2) in the document are as follows, tested on murine red blood cells: 1. DMS-PS1 Half-maximal hemolytic concentration (HC_{50}): > 512 µg/ml (at the highest tested concentration of 512 µg/ml, the hemolysis rate is still below 50%). Therapeutic index (TI): > 16 (TI = HC_{50} / geometric mean of MIC, where a higher value indicates stronger cell selectivity). 2. DMS-PS2 Half-maximal hemolytic concentration (HC_{50}): 210.7 µg/ml (this concentration causes 50% hemolysis of red blood cells). Therapeutic index (TI): 18.6 (moderate cell selectivity, and its effective antibacterial concentration is far below the hemolytic concentration). Additionally, key supplemental information: both peptides show low toxicity to mammalian red blood cells at effective antibacterial concentrations (such as MIC range 8–64 µg/ml), with DMS-PS1 having lower hemolysis and DMS-PS2 showing slightly higher hemolysis, but still retaining clinical application potential.|||Mouse erythrocytes (50% Hemolysis at >512 ug/ml" "Acta Biomater . 2020 Jun:109:208-219. doi: 10.1016/j.actbio.2020.03.024. Epub 2020 Apr 8.|||Acta Biomater. 2020 Jun;109:208-219. doi: 10.1016/j.actbio.2020.03.024. PubMed|||32276085|||Acta Biomater. 2020 Jun;109:208-219. doi: 10.1016/j.actbio.2020.03.024. PubMed|||32276085|||Acta Biomater. 2020 Jun;109:208-219. doi: 10.1016/j.actbio.2020.03.024. PubMed|||Acta Biomater. 2020 Jun;109:208-219. doi: 10.1016/j.actbio.2020.03.024. PubMed" 28 FPDB01132 AP03427|||AP03427|||Dermaseptin-PS2|||Dermaseptin-PS2|||AP03427 " ALWKTLLKNVGKAAGKAVLNAVTDMVNQ" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Antibiofilm||Anti-S. aureus NCTC 10788, activity value is MIC = 8 ug/ml||Anti-MRSA NCTC 12493, activity value is MIC = 16 ug/ml||Anti-MRSA, activity value is MIC = 8 ug/ml||Anti-C. albicans NCYC 1467, activity value is MIC = 16 ug/ml||Anti-E. coli, activity value is MIC = 8 ug/ml||Anti-and P. aeruginosa, activity value is MIC = 16 ug/ml||Anti-S. aureus, activity value is MIC = 8 uM||Anti-MRSA, activity value is MIC = 16 uM||Anti-E.coli, activity value is MIC = 8 uM||Anti-C. albicans, activity value is MIC = 16 uM Skin secretion, the waxy monkey leaf frog or waxy monkey tree frog, Phyllomedusa sauvagei, Argentina, Bolivia, Paraguay and Brazil, South America|||Phyllomedusa tomopterna [Tiger-striped leaf frog]|||Phyllomedusa sauvagii [Sauvage frog]|||Skin secretion, the waxy monkey leaf frog or waxy monkey tree frog, Phyllomedusa sauvagei, Argentina, Bolivia, Paraguay and Brazil, South America|||Skin secretion, the waxy monkey leaf frog or waxy monkey tree frog, Phyllomedusa sauvagei, Argentina, Bolivia, Paraguay and Brazil, South America Helix "Skin secretion, the waxy monkey leaf frog or waxy monkey tree frog, Phyllomedusa sauvagei, Argentina, Bolivia, Paraguay and Brazil, South America|||Horse RBC (50% hemolysis at 210.7 uM)|||The core hemolytic data for two novel dermaseptin peptides (DMS-PS1 and DMS-PS2) in the document are as follows, tested on murine red blood cells: 1. DMS-PS1 Half-maximal hemolytic concentration (HC_{50}): > 512 µg/ml (at the highest tested concentration of 512 µg/ml, the hemolysis rate is still below 50%). Therapeutic index (TI): > 16 (TI = HC_{50} / geometric mean of MIC, where a higher value indicates stronger cell selectivity). 2. DMS-PS2 Half-maximal hemolytic concentration (HC_{50}): 210.7 µg/ml (this concentration causes 50% hemolysis of red blood cells). Therapeutic index (TI): 18.6 (moderate cell selectivity, and its effective antibacterial concentration is far below the hemolytic concentration). Additionally, key supplemental information: both peptides show low toxicity to mammalian red blood cells at effective antibacterial concentrations (such as MIC range 8–64 µg/ml), with DMS-PS1 having lower hemolysis and DMS-PS2 showing slightly higher hemolysis, but still retaining clinical application potential.|||Horse RBC (50% hemolysis at 210.7 uM)" "Acta Biomater . 2020 Jun:109:208-219. doi: 10.1016/j.actbio.2020.03.024. Epub 2020 Apr 8.|||Acta Biomater. 2020 Jun;109:208-219. doi: 10.1016/j.actbio.2020.03.024. PubMed|||33582221|||Acta Biomater. 2020 Jun;109:208-219. doi: 10.1016/j.actbio.2020.03.024. PubMed|||33582221|||Acta Biomater. 2020 Jun;109:208-219. doi: 10.1016/j.actbio.2020.03.024. PubMed|||Acta Biomater. 2020 Jun;109:208-219. doi: 10.1016/j.actbio.2020.03.024. PubMed" 28 FPDB01134 AP03436|||AP03436|||BHL Bombinin GIGGALLSFGKSALKGLAKGLAEHF Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Synergistic AMPs||Anti-S. aureus, activity value is MIC = 1.6 uM||Anti-MRSA, activity value is MIC = 6.6 uM||Anti-E. coli, activity value is MIC = 6.6 uM||Anti-P. aeruginosa, activity value is MIC = 26.2 uM||Anti-and C. albicans, activity value is MIC = 1.6 uM||Gram-positive bacteria (MIC/MBC: 4000 ug/l/16000 ug/l) and yeast (MIC/MBC: 4000 ug/l/16000 ug/l) than Gram-negative bacteria (MIC/MBC: 16–64000 ug/l/64–128000 ug/l) skin secretion, Bombina orientalis, Asia|||Bombina variegata [Yellow-bellied toad]|||skin secretion, Bombina orientalis, Asia Helix "The core values related to hemolysis in this document are reflected through HC₅₀ (the peptide concentration causing 50% hemolysis) and hemolysis rate, with specific data as follows: 1. HC₅₀ values of each peptide (Table 2: The susceptibility of novel AMPs and melittin peptide...) Table Peptide Name (Peptides) | HC₅₀ (mg/l (uM)) | Notes --- | --- | --- BHL-bombinin | 64 (26.2) | - Bombinin HL | >512 (313.5) | No significant hemolysis observed at the highest tested concentration (512,000 ug/l); calculated as 1,024,000 ug/l Bombinin HD | >512 (313.5) | Same as Bombinin HL; no significant hemolysis observed at the highest tested concentration Melittin (bee venom peptide, positive control) | 1 (0.4) | Hemolytic activity far higher than the studied amphibian antimicrobial peptides 2. Supplementary information on key hemolysis rates - BHL-bombinin shows low hemolysis rates of only 0–12.6% at its MIC concentration (4,000 ug/l) against Staphylococcus aureus (S. aureus) and Candida albicans (C. albicans) (Supplementary Figure S3). - Bombinin HL and Bombinin HD did not show significant hemolytic activity even at the highest tested concentration (512,000 ug/l, HC₅₀ > 512,000 ug/l), indicating extremely low hemolytic toxicity. 3. Hemolysis-related selectivity index (SI) Selectivity Index (SI) = HC₅₀ / MIC against Staphylococcus aureus, which indirectly reflects the hemolytic safety of the peptides. Higher values indicate better safety: Table Peptide Name | SI (Selectivity Index) --- | --- BHL-bombinin | 16 Bombinin HL | 4 Bombinin HD | 8 Melittin | 0.125|||skin secretion, Bombina orientalis, Asia||HC₅₀（mg/L）＞512|||skin secretion, Bombina orientalis, Asia|||HC₅₀（mg/L）＞512|||50% hemolysis at 26.2 uM." "Biosci Rep . 2017 Sep 27;37(5):BSR20170967. doi: 10.1042/BSR20170967. Print 2017 Oct 31.|||Biosci Rep. 2017 Sep 27;37(5):BSR20170967. doi: 10.1042/BSR20170967. PubMed|||28894024|||Biosci Rep. 2017 Sep 27;37(5):BSR20170967. doi: 10.1042/BSR20170967. PubMed|||Biosci Rep. 2017 Sep 27;37(5):BSR20170967. doi: 10.1042/BSR20170967. PubMed" 25 FPDB01171 AP03715 " RHCLRSKRPPNVCPH" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-B. subtilis, activity value is MIC = 1.56 uM||Anti-S. aureus MRSA, activity value is MIC = 6.25 uM||Anti-S. enterica, activity value is MIC = 3.12 uM||Anti-P-aeruginosa, activity value is MIC > 50 uM||Anti-V-parahaemolyticus, activity value is MIC > 50 uM||Anti-and C. albicans, activity value is MIC = 25 uM Pacific white shrimp, Penaeus vannamei|||Pacific white shrimp, Penaeus vannamei N/A "(Vannamei Shrimp Cationic Cryptide Related): Hemolytic Values (Hemolysis Rate) The experiment used human red blood cells (hRBCs) as the test subjects, PBS as the blank control (0% hemolysis), and 0.1% Triton X-100 as the complete hemolysis positive control (100% hemolysis). The hemolysis rate was calculated by measuring the absorbance at 450 nm. The core data are as follows: - Low Hemolytic Risk Cryptides (Hemolysis Rate < 10%): - AD4, AD8, AD12: At the highest tested concentration of 100 μM, the hemolysis rates were all <10%, indicating high safety for human red blood cells. - AD7, AD11: Moderate hemolysis appeared at 50 μM concentration. At 100 μM, hemolysis rates were 26.5% and 20.7%, respectively, still lower than the positive control. - Positive Control Comparison: - Melittin: Nearly 100% hemolysis occurred at 12.5 μM, with hemolytic risk far higher than all cryptides. - Cisplatin: At 100 μM, hemolysis was <10%, consistent with the hemolytic characteristics of most cryptides." "Sci Rep . 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9.|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9. Pub-Med.|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9. Pub-Med." 15 FPDB01172 AP03716 " FLRWRLKFKSKVWCP" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Gram+ B. subtilis, activity value is MIC = 0.39 uM||Anti-S. aureus MRSA, activity value is MIC = 3.12 uM||Anti-S. enterica, activity value is MIC = 0.78 uM||Anti-P. aeruginosa, activity value is MIC = 6.25 uM||Anti-V. parahaemolyticus, activity value is MIC = 3.12 uM||Anti-and C. albicans, activity value is MIC = 1.56 uM Pacific white shrimp, Penaeus vannamei|||Pacific white shrimp, Penaeus vannamei N/A "(Vannamei Shrimp Cationic Cryptide Related): Hemolytic Values (Hemolysis Rate) The experiment used human red blood cells (hRBCs) as the test subjects, PBS as the blank control (0% hemolysis), and 0.1% Triton X-100 as the complete hemolysis positive control (100% hemolysis). The hemolysis rate was calculated by measuring the absorbance at 450 nm. The core data are as follows: - Low Hemolytic Risk Cryptides (Hemolysis Rate < 10%): - AD4, AD8, AD12: At the highest tested concentration of 100 μM, the hemolysis rates were all <10%, indicating high safety for human red blood cells. - AD7, AD11: Moderate hemolysis appeared at 50 μM concentration. At 100 μM, hemolysis rates were 26.5% and 20.7%, respectively, still lower than the positive control. - Positive Control Comparison: - Melittin: Nearly 100% hemolysis occurred at 12.5 μM, with hemolytic risk far higher than all cryptides. - Cisplatin: At 100 μM, hemolysis was <10%, consistent with the hemolytic characteristics of most cryptides." "Sci Rep . 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9.|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9IF: 3.8 Q1 .|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9. Pub-Med.|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9. Pub-Med." 15 FPDB01173 AP03717 " GHYCNFSVTPKFKRW" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Gram+ B. subtilis, activity value is MIC = 0.78 uM||Anti-S. aureus MRSA, activity value is MIC = 3.12 uM||Anti-S. enterica, activity value is MIC = 0.78 uM||Anti-P. aeruginosa, activity value is MIC = 25 uM||Anti-V-parahaemolyticus, activity value is MIC > 50 uM||Anti-and C. albicans, activity value is MIC = 6.25 uM Pacific white shrimp, Penaeus vannamei|||Pacific white shrimp, Penaeus vannamei N/A "(Vannamei Shrimp Cationic Cryptide Related): Hemolytic Values (Hemolysis Rate) The experiment used human red blood cells (hRBCs) as the test subjects, PBS as the blank control (0% hemolysis), and 0.1% Triton X-100 as the complete hemolysis positive control (100% hemolysis). The hemolysis rate was calculated by measuring the absorbance at 450 nm. The core data are as follows: - Low Hemolytic Risk Cryptides (Hemolysis Rate < 10%): - AD4, AD8, AD12: At the highest tested concentration of 100 μM, the hemolysis rates were all <10%, indicating high safety for human red blood cells. - AD7, AD11: Moderate hemolysis appeared at 50 μM concentration. At 100 μM, hemolysis rates were 26.5% and 20.7%, respectively, still lower than the positive control. - Positive Control Comparison: - Melittin: Nearly 100% hemolysis occurred at 12.5 μM, with hemolytic risk far higher than all cryptides. - Cisplatin: At 100 μM, hemolysis was <10%, consistent with the hemolytic characteristics of most cryptides." "Sci Rep . 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9.|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9IF: 3.8 Q1 .|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9. Pub-Med.|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9. Pub-Med." 15 FPDB01174 AP03718 RLQLNYKGKMWCPGW Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Gram+ B. subtilis, activity value is MIC = 0.78 uM||Anti-S. aureus MRSA, activity value is MIC = 6.25 uM||Anti-S. enterica, activity value is MIC = 1.56 uM||Anti-P. aeruginosa, activity value is MIC = 25 uM||Anti-and fungi C. albicans, activity value is MIC = 25 uM Pacific white shrimp, Penaeus vannamei|||Pacific white shrimp, Penaeus vannamei N/A "(Vannamei Shrimp Cationic Cryptide Related): Hemolytic Values (Hemolysis Rate) The experiment used human red blood cells (hRBCs) as the test subjects, PBS as the blank control (0% hemolysis), and 0.1% Triton X-100 as the complete hemolysis positive control (100% hemolysis). The hemolysis rate was calculated by measuring the absorbance at 450 nm. The core data are as follows: - Low Hemolytic Risk Cryptides (Hemolysis Rate < 10%): - AD4, AD8, AD12: At the highest tested concentration of 100 μM, the hemolysis rates were all <10%, indicating high safety for human red blood cells. - AD7, AD11: Moderate hemolysis appeared at 50 μM concentration. At 100 μM, hemolysis rates were 26.5% and 20.7%, respectively, still lower than the positive control. - Positive Control Comparison: - Melittin: Nearly 100% hemolysis occurred at 12.5 μM, with hemolytic risk far higher than all cryptides. - Cisplatin: At 100 μM, hemolysis was <10%, consistent with the hemolytic characteristics of most cryptides." "Sci Rep . 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9.|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9IF: 3.8 Q1 .|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9. Pub-Med.|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9. Pub-Med." 15 FPDB01175 AP03719|||AP03719|||AP03721 " FFALQCAAKTRTRRV" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-Gram+ B. subtilis, activity value is MIC = 0.78 uM||Anti-S. aureus MRSA, activity value is MIC = 6.25 uM||Anti-S. enterica, activity value is MIC = 0.78 uM||Anti-P. aeruginosa, activity value is MIC = 12.5 uM||Anti-V-parahaemolyticus, activity value is MIC > 50 uM||Anti-and fungi C. albicans, activity value is MIC = 12.5 uM Pacific white shrimp, Penaeus vannamei|||Pacific white shrimp, Penaeus vannamei N/A "(Vannamei Shrimp Cationic Cryptide Related): Hemolytic Values (Hemolysis Rate) The experiment used human red blood cells (hRBCs) as the test subjects, PBS as the blank control (0% hemolysis), and 0.1% Triton X-100 as the complete hemolysis positive control (100% hemolysis). The hemolysis rate was calculated by measuring the absorbance at 450 nm. The core data are as follows: - Low Hemolytic Risk Cryptides (Hemolysis Rate < 10%): - AD4, AD8, AD12: At the highest tested concentration of 100 μM, the hemolysis rates were all <10%, indicating high safety for human red blood cells. - AD7, AD11: Moderate hemolysis appeared at 50 μM concentration. At 100 μM, hemolysis rates were 26.5% and 20.7%, respectively, still lower than the positive control. - Positive Control Comparison: - Melittin: Nearly 100% hemolysis occurred at 12.5 μM, with hemolytic risk far higher than all cryptides. - Cisplatin: At 100 μM, hemolysis was <10%, consistent with the hemolytic characteristics of most cryptides." "Sci Rep . 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9.|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9IF: 3.8 Q1 .|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9. Pub-Med.|||Sci Rep. 2023 Sep 6;13(1):14673. doi: 10.1038/s41598-023-41581-9. Pub-Med." 15 FPDB01180 AP03756|||AP03756|||BMAP27|||Myeloid antimicrobial peptide BMAP-27|||DRAMP02872|||Myeloid antimicrobial peptide BMAP-27|||AP03756 " GRFKRFRKKFKKLFKKLS" Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anti-MRSA||Anti-inflammatory||Antibiofilm||Anti-Staphylococcus epidermidis ATCC 35984, activity value is MIC = 2 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 4 uM||Anti-E. coli ATCC 25922, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 2 uM||Anti-E. coli ML35, activity value is MIC = 4 uM||Anti-E. coli D21, activity value is MIC = 4 uM||Anti-S. typhimurium ATCC 14028, activity value is MIC = 4 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-S. marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2 uM||Anti-S. aureus Cowan 1, activity value is MIC = 2 uM||Anti-S. aureus MRSA, activity value is MIC = 4 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1 uM||Anti-B. megaterium Bm11, activity value is MIC = 2 uM||Anti-C. albicans, activity value is MIC = 16 uM||Anti-C. neoformans, activity value is MIC = 4 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2 uM||Anti-Escherichia coli ML35, activity value is MIC = 4 uM||Anti-Escherichia coli D21, activity value is MIC = 4 uM||Anti-Salmonella typhimurium ATCC 14028, activity value is MIC = 4 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-Serratia marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2 uM||Anti-Staphylococcus aureus Cowan 1, activity value is MIC = 2 uM||Anti-Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 1 uM||Anti-Bacillus megaterium Bm11, activity value is MIC = 2 uM||Anti-Cryptococcus neoformans, activity value is MIC = 4 uM||Anti-E. coli ATCC 25922 ML-35 or D21, activity value is MIC = 2||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1||Anti-S. aureus ATCC 25923 Cowan 1 or MRSA, activity value is MIC = 2||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1||Anti-and C. neoformans, activity value is MIC = 4 uM||Anti-parasite BSF and PCF of T. b. brucei, activity value is IC50 = 8 Sequence truncation, animal-derived, natural derivative|||Sequence truncation, animal-derived, natural derivative|||Synthetic construct|||Bos taurus [Bovine]|||Bos taurus (Bovine)|||Sequence truncation, animal-derived, natural derivative Helix "w6n181zke7dmzxeu2br7|||Thehemolyticactivityof thetwoBMAPswasmuchlower, whenmeasuredonbovineerythrocytes(datanotshown).These cellswere5±10-foldlesssusceptiblethanhumanredbloodcells toBMAP-28(3,6,and22%hemolysisat10,30,and100000000 uM peptide),andvirtuallyunaffectedbyBMAP-27evenat100000000 uM.|||BMAP-28 can cause 14.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate exceeds 90% at 100 μM. BMAP-27 can cause 3.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate is 32.7% at 100 μM. Cow red blood cells are 5-10 times less sensitive to BMAP-28 than human red blood cells, with hemolysis rates of 3%, 6%, and 22% at concentrations of 10 μM, 30 μM, and 100 μM, respectively; BMAP-27 shows almost no hemolytic effect on cow red blood cells at 100 μM. The hemolytic effect of the truncated analog BMAP-27(1-18) disappears, and the hemolytic effect of BMAP-28(1-18) is greatly reduced. The modified analog mBMAP-28 has a hemolysis rate of only 3.3% for human red blood cells at 100 μM, far lower than the 94.1% of the parent peptide BMAP-28.|||sheep RBC: not hemolytic until 20 uM. 20% hemolysis at 30-130 uM.|||sheep RBC: not hemo.lytic until 20 uM. 20% hemolysis at 30-130 uM. HC50 at 16-32 uM to RAW264.7 mouse macrophages." J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461.|||J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461.|||8910461|||J Biol Chem. 1996 Nov 8;271(45):28375-28381.|||8910461|||J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461.|||J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461.||Haines et al., 2009 18 FPDB01181 AP03757|||AP03757|||Myeloid antimicrobial peptide BMAP-28|||S6|||DRAMP02873|||Myeloid antimicrobial peptide BMAP-28|||AP03757 " GGLRSLGRKILRAWKKYG" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli ATCC 25922, activity value is MIC = 1 uM||Anti-E. coli ML35, activity value is MIC = 0.5 uM||Anti-E. coli D21, activity value is MIC = 0.5 uM||Anti-S. typhimurium ATCC14028, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-S. marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2 uM||Anti-S. aureus Cowan 1, activity value is MIC = 1 uM||Anti-S. aureus, activity value is MIC = 4 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 1 uM||Anti-B. megaterium Bm11, activity value is MIC = 2 uM||Anti-C. albicans, activity value is MIC = 16 uM||Anti-C.neoformans, activity value is MIC = 2 uM||M. abscessus ATCC19977 (MIC= >400 ug/ml)||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 uM||Anti-Escherichia coli ML35, activity value is MIC = 0.5 uM||Anti-Escherichia coli D21, activity value is MIC = 0.5 uM||Anti-Salmonella typhimurium ATCC14028, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-Serratia marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2 uM||Anti-Staphylococcus aureus Cowan 1, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 1 uM||Anti-Bacillus megaterium Bm11, activity value is MIC = 2 uM||Anti-Cryptococcus neoformans, activity value is MIC = 2 uM||Anti-E. coli ATCC 25922 ML-35 or D21, activity value is MIC = 0.5||Anti-S. typhimurium ATCC 14028, activity value is MIC = 2 uM||Anti-S. aureus ATCC 25923 Cowan 1 or MRSA, activity value is MIC = 2||Anti-and C. neoformans, activity value is MIC = 2 uM Sequence truncation, animal-derived, natural derivative|||Sequence truncation, animal-derived, natural derivative|||Bos taurus [Bovine]|||Bos taurus (Bovine)|||Sequence truncation, animal-derived, natural derivative Helix "w6n181zke7dmzxeu2br7|||Thehemolyticactivityof thetwoBMAPswasmuchlower, whenmeasuredonbovineerythrocytes(datanotshown).These cellswere5±10-foldlesssusceptiblethanhumanredbloodcells toBMAP-28(3,6,and22%hemolysisat10,30,and100000000 uM peptide),andvirtuallyunaffectedbyBMAP-27evenat101000000 uM.|||BMAP-28 can cause 14.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate exceeds 90% at 100 μM. BMAP-27 can cause 3.5% hemolysis of human red blood cells at a concentration of 3 μM, and the hemolysis rate is 32.7% at 100 μM. Cow red blood cells are 5-10 times less sensitive to BMAP-28 than human red blood cells, with hemolysis rates of 3%, 6%, and 22% at concentrations of 10 μM, 30 μM, and 100 μM, respectively; BMAP-27 shows almost no hemolytic effect on cow red blood cells at 100 μM. The hemolytic effect of the truncated analog BMAP-27(1-18) disappears, and the hemolytic effect of BMAP-28(1-18) is greatly reduced. The modified analog mBMAP-28 has a hemolysis rate of only 3.3% for human red blood cells at 100 μM, far lower than the 94.1% of the parent peptide BMAP-28.|||Hemolysis is much reduced compared to the parent peptide.|||Hemolysis is much reduced compared to the parent peptide." J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461.|||J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461.|||8910461|||34780520|||J Biol Chem. 1996 Nov 8;271(45):28375-28381.|||8910461|||J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461.|||J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461. 18 FPDB01185 AP03821 " GIINTLQKYYCRVRGAICHPVFCPRRYKQIGTCGLPGTKCCKKP" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-both E. coli, activity value is MBC = 0.1 ug/ml||Anti-P. aeruginosa, activity value is MBC = 1.56 ug/ml||Anti-E. faecalis ATCC 51299, activity value is MBC = 0.78 ug/ml||Anti-E. faecium 4 strains, activity value is MBC = 0.78||Anti-S. aureus MRSA, activity value is MBC = 0.78 ug/ml||Anti-and C. albicans 5 strains, activity value is MBC = 12.5||Anti-C.perfringens ATCC 13124, activity value is MBC > 100 ug/ml||Anti-P. anaerobius ATCC 27337, activity value is MBC = 50 ug/ml||Anti-P. acnes ATCC 6919, activity value is MBC = 1.56 ug/ml||Anti-and P. oralis ATCC 33321, activity value is MBC > 100 ug/ml Hybrid peptide, designed, man-made sequences Combine Helix and Beta structure "In this research document, only the hemolytic data of chimera peptide C5 is mentioned, while the hemolytic values for HBD2, HBD3, and other chimera peptides (such as C1-C4, C6) are not covered. The specific information is as follows: - Peptide C5: Under physiological saline conditions at pH 7.4 with 150,000 µM NaCl, no hemolytic activity was observed on fresh human red blood cells, even at the highest tested concentration of 20 µM (hemolysis rate was 0%). - Control peptide (bee venom peptide, melittin): As a strong hemolytic control, at the same concentration (20 µM), the hemolysis rate approached 100%. This data is sourced from the ""Hemolysis"" section of the document and Figure 5 (Hemolytic activity of bee venom melittin and chimera C5 against human red blood cells). Hemolysis was calculated by measuring the release of hemoglobin from human red blood cells, with distilled water as the maximum hemolysis control (100% hemolysis) and peptide-containing buffer solution as the spontaneous hemolysis control (0% hemolysis)." "Antimicrob Agents Chemother . 2011 Mar;55(3):954-60. doi: 10.1128/AAC.00872-10. Epub 2010 Dec 28.|||Antimicrob Agents Chemother. 2011 Mar;55(3):954-60. doi: 10.1128/AAC.00872-10. PubMed|||Antimicrob Agents Chemother. 2011 Mar;55(3):954-60. doi: 10.1128/AAC.00872-10. PubMed" 44 FPDB01187 AP03823|||AP03823|||Pilosulin-1|||Pilosulin P1|||Peptide P1|||Pilosulin-1|||Pilosulin P1|||Peptide P1|||AP03823|||DRAMP18666 " GLGSVFGRLARILGRVIPKV" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli ML-35, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 4||Anti-S. typhimurium ATCC 14028, activity value is MIC = 8 ug/ml||Anti-S. aureus 710A or MRSA, activity value is MIC = 1.5||Anti-and B. megaterium BM11, activity value is MIC = 2 uM||Anti-M. luteus, activity value is MIC = 0.5 uM||Anti-Enterococcus spp, activity value is MIC = 2 uM||Anti-S. haemolyticus I-10925, activity value is MIC = 2 uM||Anti-S. epidermidis, activity value is MIC = 2 uM||Anti-C. freundii I-11090, activity value is MIC = 2 uM||Anti-K. pneumoniae I-10910, activity value is MIC = 2 uM||Anti-S. maltophila O-16451, activity value is MIC = 2 uM||Anti-and C. albicans, activity value is MIC = 4 uM||Antibacterial ; Myrmecia pilosula [Jack jumper ant]||Anti-S. simulans 22, activity value is MIC = 2 uM||Anti-Enterococcus spp. I-11305b, activity value is MIC = 2 uM||Anti-Enterococcus spp. I-11054, activity value is MIC = 2 uM||Anti-S. epidermidis LT1324, activity value is MIC = 2 uM||Anti-S. aureus 5185, activity value is MIC = 2 uM||Anti-S. aureus methicillin-sensitive I-11574, activity value is MIC = 2 uM||Anti-S. aureus MRSA LT1338, activity value is MIC = 3 uM||Anti-S. aureus MRSA LT1334, activity value is MIC = 1.5 uM||Anti-E. coli I-11276b, activity value is MIC = 4 uM||Anti-E. coli O-19592, activity value is MIC = 2 uM||Anti-S. maltophila I-10717, activity value is MIC = 2 uM||Anti-P. aeruginosa 4991, activity value is MIC = 4 uM||Anti-P. aeruginosa I-10968, activity value is MIC = 4 uM||Anti-C. albicans I-11301, activity value is MIC = 4 uM||Anti-E. coli, activity value is MIC = 2 uM||Anti-P. aeruginosa, activity value is MIC = 8 uM||Anti-S. typhimurium, activity value is MIC = 8 uM||Anti-S. aureus, activity value is MIC = 4 uM||Anti-B. megaterium, activity value is MIC = 2 uM||Anti-I-11305b, activity value is MIC = 2 uM||Anti-I-11054, activity value is MIC = 2 uM||Anti-I-10925, activity value is MIC = 2 uM||Anti-LT1324, activity value is MIC = 2 uM||Anti-5185, activity value is MIC = 2 uM||Anti-I-11574, activity value is MIC = 2 uM||Anti-LT1338, activity value is MIC = 3 uM||Anti-LT1334, activity value is MIC = 1.5 uM||Anti-I-11090, activity value is MIC = 2 uM||Anti-I-10910, activity value is MIC = 2 uM||Anti-I-11276b, activity value is MIC = 4 uM||Anti-O-19592, activity value is MIC = 2 uM||Anti-O-16451, activity value is MIC = 2 uM||Anti-I-10717, activity value is MIC = 2 uM||Anti-4991, activity value is MIC = 4 uM||Anti-I-10968, activity value is MIC = 4 uM||Anti-I-11301, activity value is MIC = 4 uM||Antibacterial||Anti-Staphylococcus aureus 710A, activity value is MIC = 4 uM||Anti-Bacillus megaterium BM11, activity value is MIC = 2 uM||Anti-##Gram-negative bacteria: Escherichia coli ML-35, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 8 uM||Anti-Salmonella typhimurium ATCC14028, activity value is MIC = 8 uM||Anti-Micrococcus luteus, activity value is MIC = 0.5 uM||Anti-Staphylococcus haemolyticus I-10925, activity value is MIC = 2 uM||Anti-Staphylococcus epidermidis LT1324, activity value is MIC = 2 uM||Anti-Staphylococcus aureus 5185, activity value is MIC = 2 uM||Anti-Staphylococcus aureus I-11574, activity value is MIC = 2 uM||Anti-Staphylococcus aureus LT1338, activity value is MIC = 3 uM||Anti-Staphylococcus aureus T1334, activity value is MIC = 1.5 uM||Anti-Citrobacter freundii I-11090, activity value is MIC = 2 uM||Anti-Klebsiella pneumoniae I-10910, activity value is MIC = 2 uM||Anti-Escherichia coli I-11276b, activity value is MIC = 4 uM||Anti-Escherichia coli O-19592, activity value is MIC = 2 uM||Anti-Stenotrophomonas maltophilia O-16451, activity value is MIC = 2 uM||Anti-Stenotrophomonas maltophilia I-10717, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa 4991, activity value is MIC = 4 uM||Anti-Pseudomonas aeruginosa I-10968, activity value is MIC = 4 uM||Anti-Candida albicans I-11301, activity value is MIC = 4 uM Sequence truncation|||Sequence truncation|||Myrmecia pilosula [Jack jumper ant]|||Myrmecia pilosula [Australian jumper ant]|||Myrmecia pilosula [Jumper ant]|||Myrmecia pilosula (Jumper ant) Helix||Alpha helix "In this research document, only the hemolytic data of chimera peptide C5 is mentioned, while the hemolytic values for HBD2, HBD3, and other chimera peptides (such as C1-C4, C6) are not covered. The specific information is as follows: - Peptide C5: Under physiological saline conditions at pH 7.4 with 150,000 µM NaCl, no hemolytic activity was observed on fresh human red blood cells, even at the highest tested concentration of 20 µM (hemolysis rate was 0%). - Control peptide (bee venom peptide, melittin): As a strong hemolytic control, at the same concentration (20 µM), the hemolysis rate approached 100%. This data is sourced from the ""Hemolysis"" section of the document and Figure 5 (Hemolytic activity of bee venom melittin and chimera C5 against human red blood cells). Hemolysis was calculated by measuring the release of hemoglobin from human red blood cells, with distilled water as the maximum hemolysis control (100% hemolysis) and peptide-containing buffer solution as the spontaneous hemolysis control (0% hemolysis).|||29% hemolysis at 10 uM and 100% hemolysis at 100 uM.|||S. simulans 22 ( MIC = 2 uM ), M. luteus ( MIC = 0.5 uM ), Enterococcus spp. I-11305b ( MIC = 2 uM ), Enterococcus spp. I-11054 ( MIC = 2 uM ), S. haemolyticus I-10925 ( MIC = 2 uM ), S. epidermidis ( MIC = methicillin-sensitive ), S. epidermidis LT1324 ( MIC = 2 uM ), S. aureus ( MIC = methicillin-sensitive ), S. aureus 5185 ( MIC = 2 uM ), S. aureus methicillin-sensitive I-11574 ( MIC = 2 uM ), S. aureus MRSA LT1338 ( MIC = 3 uM ), S. aureus MRSA LT1334 ( MIC = 1.5 uM ), C. freundii I-11090 ( MIC = 2 uM ), K. pneumoniae I-10910 ( MIC = 2 uM ), E. coli I-11276b ( MIC = 4 uM ), E. coli O-19592 ( MIC = 2 uM ), S. maltophila O-16451 ( MIC = 2 uM ), S. maltophila I-10717 ( MIC = 2 uM ), P. aeruginosa 4991 ( MIC = 4 uM ), P. aeruginosa I-10968 ( MIC = 4 uM ), C. albicans I-11301 ( MIC = 4 uM ), C. albicans I-11134 ( MIC = >4 uM )|||Human erythrocyte (100% hemolysis at 100 uM )|||Human erythrocyte (100% hemolysis at 100 uM )|||29% hemolysis at 10 uM and 100% hemolysis at 100 uM.|||[Ref.15639237]20% hemolysis at 10 uM, 100% hemolysis at 100 uM against human red blood cells|||29% hemolysis at 10 uM and 100% hemolysis at 100 uM." "Arch Biochem Biophys . 2005 Feb 15;434(2):358-64. doi: 10.1016/j.abb.2004.11.006.|||Arch Biochem Biophys. 2005 Feb 15;434(2):358-64. doi: 10.1016/j.abb.2004.11.006. PubMed|||https://pubmed.ncbi.nlm.nih.gov/15639237|||15639237|||28470277|||15639237|||28470277|||Arch Biochem Biophys. 2005 Feb 15;434(2):358-64. doi: 10.1016/j.abb.2004.11.006. PubMed|||Arch Biochem Biophys. 2005 Feb 15;434(2):358-64.||Ref.15639237|||Arch Biochem Biophys. 2005 Feb 15;434(2):358-64. doi: 10.1016/j.abb.2004.11.006. PubMed" 20 FPDB01217 AP03892|||AP03892|||AP03893|||TetraF2W-KR|||TetraF2W-KR|||AP03892 WWWLKRIW Anti-E. coli K12, activity value is MIC = 12.5||Anti-S. epidermidis 1457, activity value is MIC = 12.5 uM||Anti-B. subtilis 168, activity value is MIC = 6.2 uM||Anti-and S. aureus USA300, activity value is MIC = 3.1 uM||activity value is MBC = 12.5 uM||Anti-C. glabrata, activity value is MIC = 12.5 uM||Anti-and C. tropicalis, activity value is MIC = 3.1||Anti-Escherichia coli K-12, activity value is MIC = 12.5||Anti-Staphylococcus epidermidis 1457, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis 168, activity value is MIC = 6.2 uM||Anti-Staphylococcus aureus USA 300, activity value is MIC = 3.1 uM||Anti-Staphylococcus aureus USA 300, activity value is MBC = 12.5 uM||Anti-Staphylococcus aureus USA 300, activity value is MIC = 6.2 uM||Anti-Staphylococcus aureus USA 300, activity value is MIC = 25 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 12.5 uM||Anti-Candida glabrata ATCC 2001, activity value is MIC = 12.5 uM||Anti-Candida tropicalis ATCC 13803, activity value is MIC = 3.1 Amino acid substitution, designed|||Synthetic construct|||Amino acid substitution, designed Rich "TetraF2W-KK: Human red blood cells 40 uM, pig red blood cells 55 uM, chicken red blood cells 50 uM TetraF2W-KR: Human red blood cells 30 uM, pig red blood cells 50 uM, chicken red blood cells 35 uM TetraF2W-RK: Human red blood cells 30 uM, pig red blood cells 40 uM, chicken red blood cells 35 uM TetraF2W-RR: Human red blood cells 20 uM, pig red blood cells 40 uM, chicken red blood cells 55 uM|||human RBC HC50 30 uM.|||Human erythrocytes (50% Hemolysis at 30 uM|||human RBC HC50 30 uM." 2017 Feb:49:316-328. doi: 10.1016/j.actbio.2016.11.061. Epub 2016 Nov 30.|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed|||27915018|||https://pubmed.ncbi.nlm.nih.gov/27915018|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed 8 FPDB01218 AP03893|||TetraF2W-RK " WWWLRKIW" Anti-E. coli K12 or ATCC 25922, activity value is MIC = 6.2||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 12.5 uM||Anti-S. epidermidis 1457, activity value is MIC = 6.2 uM||Anti-B. subtilis 168, activity value is MIC = 6.2 uM||Anti-and S. aureus USA300, activity value is MIC = 3.1 uM||activity value is MBC = 12.5 uM||Anti-C. glabrata, activity value is MIC = 12.5 uM||Anti-and C. tropicalis, activity value is MIC = 3.1||Anti-S. aureus, activity value is MIC = 3.1 uM||Anti-E. coli, activity value is MIC = 6.2 uM Amino acid substitution, designed Helix "TetraF2W-KK: Human red blood cells 40 uM, pig red blood cells 55 uM, chicken red blood cells 50 uM TetraF2W-KR: Human red blood cells 30 uM, pig red blood cells 50 uM, chicken red blood cells 35 uM TetraF2W-RK: Human red blood cells 30 uM, pig red blood cells 40 uM, chicken red blood cells 35 uM TetraF2W-RR: Human red blood cells 20 uM, pig red blood cells 40 uM, chicken red blood cells 55 uM|||Human RBCs(HL50 = 35 uM)|||human RBC HC50 30 uM." 2017 Feb:49:316-328. doi: 10.1016/j.actbio.2016.11.061. Epub 2016 Nov 30.|||28731688, 33804947|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed 8 FPDB01219 AP03894|||AP03894|||TetraF2W-KK|||TetraF2W-KK|||AP03894 " WWWLKKIW" Anti-E. coli K12, activity value is MIC = 12.5||Anti-S. epidermidis 1457, activity value is MIC = 6.2 uM||Anti-B. subtilis 168, activity value is MIC = 6.2 uM||Anti-and S. aureus USA300, activity value is MIC = 3.1||activity value is MBC > 25 uM||Anti-C. glabrata, activity value is MIC = 6.2||Anti-and C. tropicalis, activity value is MIC = 1.6 uM||Anti-Escherichia coli K-12, activity value is MIC = 12.5||Anti-Staphylococcus epidermidis 1457, activity value is MIC = 6.2 uM||Anti-Bacillus subtilis 168, activity value is MIC = 6.2 uM||Anti-Staphylococcus aureus USA 300, activity value is MIC = 3.1||Anti-Staphylococcus aureus USA 300, activity value is MBC > 25 uM||Anti-Staphylococcus aureus USA 300, activity value is MIC = 3.1 uM||Anti-Staphylococcus aureus USA 300, activity value is MIC = 12.5 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 6.2 uM||Anti-Candida glabrata ATCC 2001, activity value is MIC = 6.2||Anti-Candida tropicalis ATCC 13803, activity value is MIC = 1.6 uM Amino acid substitution, designed|||Synthetic construct|||Amino acid substitution, designed Rich "TetraF2W-KK: Human red blood cells 40 uM, pig red blood cells 55 uM, chicken red blood cells 50 uM TetraF2W-KR: Human red blood cells 30 uM, pig red blood cells 50 uM, chicken red blood cells 35 uM TetraF2W-RK: Human red blood cells 30 uM, pig red blood cells 40 uM, chicken red blood cells 35 uM TetraF2W-RR: Human red blood cells 20 uM, pig red blood cells 40 uM, chicken red blood cells 55 uM|||human RBC HC50 40 uM.|||Human erythrocytes (50% Hemolysis at 40 uM|||human RBC HC50 40 uM." 2017 Feb:49:316-328. doi: 10.1016/j.actbio.2016.11.061. Epub 2016 Nov 30.|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed|||27915018|||https://pubmed.ncbi.nlm.nih.gov/27915018|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed 8 FPDB01220 AP03895|||AP03895|||WT WWWLRRIW Anti-E. coli K12, activity value is MIC = 25 uM||Anti-S. epidermidis 1457, activity value is MIC = 6.2||Anti-B. subtilis 168, activity value is MIC = 3.1||Anti-and S. aureus USA300, activity value is MIC = 1.6||activity value is MBC = 3.1 uM||Anti-C-glabrata, activity value is MIC > 25 uM||Anti-and C. tropicalis, activity value is MIC = 3.1 uM||Anti-S. aureus, activity value is MIC = 3.1 uM||Anti-E. coli, activity value is MIC = 6.2 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Antibiofilm Amino acid substitution, designed Rich "TetraF2W-KK: Human red blood cells 40 uM, pig red blood cells 55 uM, chicken red blood cells 50 uM TetraF2W-KR: Human red blood cells 30 uM, pig red blood cells 50 uM, chicken red blood cells 35 uM TetraF2W-RK: Human red blood cells 30 uM, pig red blood cells 40 uM, chicken red blood cells 35 uM TetraF2W-RR: Human red blood cells 20 uM, pig red blood cells 40 uM, chicken red blood cells 55 uM|||human RBC HC50 20 uM.|||Human RBC (HL50 = 35 uM)|||The hemolytic-related data provided in the document represent the 50% hemolysis concentrations (LC_{50}) of different TetraF2W series peptides against various red blood cells and human cells. The specific values are shown in the table below (unit: µM): Peptide Name | Human RBCs | Pig RBCs | Chicken RBCs | Human HEK293 Cells | Human HaCaT Cells | Human HeLa Cells TetraF2W-KK | 40 | 55 | 50 | 50 | 50 | 70 TetraF2W-KR | 30 | 50 | 35 | 55 | 60 | 100 TetraF2W-RK | 30 | 40 | 35 | 60 | 60 | >100 TetraF2W-RR | 20 | 40 | 55 | 70 | 70 | 60 Supplementary Notes: Hemolysis tests used 1% Triton X-100 treated corresponding red blood cells as the 100% hemolysis positive control and PBS buffer treated cells as the 0% hemolysis negative control. Hemolysis rate was calculated by measuring hemoglobin release at 545 nm. LC_{50} is the peptide concentration that causes 50% of the cells to undergo hemolysis. There are differences in sensitivity to peptides among red blood cells of different origins: pig red blood cells are most similar in sensitivity to human red blood cells, followed by chicken red blood cells. Cow red blood cells are the least sensitive to these peptides (hemolysis rate at 50 µM concentration is only 10-20%, not included in the table above). From a cytotoxicity perspective, TetraF2W-RR has the highest LC_{50} against normal human cells (HEK293, HaCaT) at 70 µM, indicating relatively low toxicity; whereas TetraF2W-KK is the most toxic to human red blood cells (LC_{50} = 20 µM).|||human RBC HC50 20 uM." 2017 Feb:49:316-328. doi: 10.1016/j.actbio.2016.11.061. Epub 2016 Nov 30.|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed|||28731688|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed|||Acta Biomater. 2017 Feb;49:316-328. doi: 10.1016/j.actbio.2016.11.061. PubMed 8 FPDB01336 AP04269|||AP04269|||CAMPSQ8801|||DRAMP20816 " KILGKLWKGVKSIF" Anti-Gram- E. coli AB94012 or ATCC25922, activity value is MIC = 25||Anti-P. aeruginosa AB93066 or ATCC9027, activity value is MIC = 50 ug/ml||Anti-S. aureus AB94004 or ATCC25923 or MRSA P1381 or MRSA P1374, activity value is MIC = 6.25||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-E. coli AB94012, activity value is MIC = 25 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 50 ug/ml||Anti-P. aeruginosa AB93066, activity value is MIC = 50 ug/ml||Anti-P. aeruginosa ATCC9027, activity value is MIC = 50 ug/ml||Anti-S. aureus AB94004, activity value is MIC = 6.25 ug/ml||Anti-S. aureus ATCC6538, activity value is MIC = 12.5 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 12.5 ug/ml||Anti-S. aureus MRSA P1381, activity value is MIC = 6.25 ug/ml||Anti-S. aureus MRSA P1374, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus AB94004, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus ATCC6538, activity value is MIC = 12.5 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 12.5 ug/ml||Anti-Staphylococcus aureus MRSA P1381, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus MRSA P1374, activity value is MIC = 6.25 ug/ml||Anti-##Gram-negative bacteria: Escherichia coli AB94012, activity value is MIC = 25 ug/ml||Anti-Escherichia coli ATCC25922, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa AB93066, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa ATCC9027, activity value is MIC = 50 ug/ml amino acid substitution, animal-derived, natural derivative|||amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct Helix||Alpha helix Hp1404: At a concentration of 400 ug/ml, the hemolysis is 100%. K8: At a concentration of 400 ug/ml, the hemolysis is 32.5%. L1K8: At a concentration of 400 ug/ml, the hemolysis is 11.5%. S1K8: At a concentration of 400 ug/ml, the hemolysis is 26.5%. F1K8: At a concentration of 400 ug/ml, the hemolysis is 21.5%. K1K8: At a concentration of 400 ug/ml, the hemolysis is 11.5%.|||Human RBC (10% hemolytic at 400 ug/ml)|||[Ref.26952110] 10% hemolysis at 400 ug/ml against human red blood cells|||human RBC: HC50: >>400 ug/ml, ~10% hemo.lytic at 400 ug/ml (similar to L1K8, least in the series). 2016 Jun;100(11):5069-77. doi: 10.1007/s00253-016-7395-x. Epub 2016 Mar 8.||Shui et al., 2024|||Appl Microbiol Biotechnol. 2016 Jun;100(11):5069-77. doi: 10.1007/s00253-016-7395-x. PubMed|||26952110|||Appl Microbiol Biotechnol. 2016 Jun;100(11):5069-77.||Ref.26952110|||Appl Microbiol Biotechnol. 2016 Jun;100(11):5069-77. doi: 10.1007/s00253-016-7395-x. PubMed||Shui et al., 2024 14 FPDB01347 AP04601|||AP04601|||N1 " GFCWNVCVYRNGVRVCHRRCN" Anti-Gram- bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7, activity value is MIC = 0.25||Anti-S. typhimurium ATCC14028, activity value is MIC = 0.5 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 0.25 ug/ml||Anti-S. pullorum CVCC1789 or CVCC1802, activity value is MIC = 0.25 ug/ml||Anti-S. choleraesuis CV, activity value is CC50 = 3||Anti-P. aeruginosa CICC10419 or CICC21630, activity value is MIC = 2||Anti-S. aureus ATCC43300 MRSA or ATCC25923, activity value is MIC = 0.5||Anti-S. suis CVCC606, activity value is MIC = 16 ug/ml||Anti-E-faecium CMCC1.2136, activity value is MIC > 16 ug/ml||Anti-B. subtilis ATCC6633, activity value is MIC = 0.25 ug/ml||Anti-L.ivanovii ATCC19119, activity value is MIC = 128 ug/ml||Anti-C. albicans CGMCC2.2411, activity value is MIC = 16 ug/ml||Anti-Escherichia coli CVCC195, activity value is MIC = 0.5||Anti-E. coli CVCC1515, activity value is MIC = 0.25 ug/ml||Anti-E. coli CICC21530, activity value is MIC = 0.5 ug/ml||Anti-Salmonella typhimurium ATCC14028, activity value is MIC = 0.5 ug/ml||Anti-S. pullorum CVCC1789, activity value is MIC = 0.25 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 0.25 ug/ml||Anti-Pseudomonas aeruginosa CICC10419, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa CICC21630, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 16 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 0.5||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 0.25 ug/ml||Anti-Listeria ivanovii ATCC19119, activity value is MIC = 128 ug/ml||Anti-Candida albicans CGMCC2.2411, activity value is MIC = 16 ug/ml amino acid substitution, animal-derived, natural derivative|||amino acid substitution, animal-derived, natural derivative|||Arenicola marina Beta N1: At a concentration of 128 µg/ml, hemolysis is 3%. N2: At a concentration of 128 µg/ml, hemolysis is 0.4%; at a concentration of 256 µg/ml, hemolysis is 3.8%. N6: At a concentration of 128 µg/ml, hemolysis is 0.04%; at a concentration of 256 µg/ml, hemolysis is 1.9%. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2.|||Sci Rep. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2. PubMed|||28611436|||Sci Rep. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2. PubMed 21 FPDB01348 AP04602|||AP04602|||N2 " AFCWNVCVYRNAVRVCHRRCN" Anti-Gram- bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7, activity value is MIC = 0.25||Anti-S. typhimurium ATCC14028, activity value is MIC = 1 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 0.125 ug/ml||Anti-S. pullorum CVCC1789 or CVCC1802, activity value is MIC = 0.25||Anti-S. choleraesuis CV, activity value is CC50 = 3||Anti-P. aeruginosa CICC10419 or CICC21630, activity value is MIC = 2 ug/ml||Anti-S. aureus ATCC43300 MRSA or ATCC25923, activity value is MIC = 0.25||Anti-S. suis CVCC606, activity value is MIC = 16 ug/ml||Anti-E. faecium CMCC1.2136, activity value is MIC = 4 ug/ml||Anti-B. subtilis ATCC6633, activity value is MIC = 0.5 ug/ml||Anti-L. ivanovii ATCC19119, activity value is MIC = 4 ug/ml||Anti-C. albicans CGMCC2.2411, activity value is MIC = 32 ug/ml||Anti-Escherichia coli CVCC195, activity value is MIC = 0.25 ug/ml||Anti-E. coli CVCC1515a, activity value is MIC = 0.5 ug/ml||Anti-E. coli CICC21530, activity value is MIC = 0.25 ug/ml||Anti-Salmonella typhimurium ATCC14028, activity value is MIC = 1 ug/ml||Anti-S. pullorum CVCC1789, activity value is MIC = 0.5 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 0.25 ug/ml||Anti-Pseudomonas aeruginosa CICC10419, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa CICC21630, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 16 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 0.25 ug/ml||Anti-Enterococcus faecium CMCC1.2136, activity value is MIC = 4 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 0.5 ug/ml||Anti-Listeria ivanovii ATCC19119, activity value is MIC = 4 ug/ml||Anti-Candida albicans CGMCC2.2411, activity value is MIC = 32 ug/ml||Anti-S. typhimurium, activity value is MIC = 0.78 uM amino acid substitution, animal-derived, natural derivative|||amino acid substitution, animal-derived, natural derivative|||Synthetic construct Beta "N1: At a concentration of 128 µg/ml, hemolysis is 3%. N2: At a concentration of 128 µg/ml, hemolysis is 0.4%; at a concentration of 256 µg/ml, hemolysis is 3.8%. N6: At a concentration of 128 µg/ml, hemolysis is 0.04%; at a concentration of 256 µg/ml, hemolysis is 1.9%.|||At a concentration of 128 µg/mL, the hemolysis rate of mouse red blood cells was 0.4%; at a concentration of 256 µg/mL, the hemolysis rate was 3.8%. At a concentration of N6:128 µg/mL, the hemolysis rate of mouse red blood cells was 0.04%; at a concentration of 256 µg/mL, the hemolysis rate was 1.9%. At a concentration of 32 µg/mL, the parent peptide N1 exhibited a hemolysis rate of 3% (for comparative reference).|||murine RBC: 4% hemolysis at 256 ug/ml (low hemo.lytic)." 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2.|||Sci Rep. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2. PubMed|||28611436|||29329001|||Sci Rep. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2. PubMed 21 FPDB01350 AP04606|||AP04606|||N6|||N6-NH2-miniPEG|||N6-NH2-PEG6|||N6-NH2-PEG12|||N6-NH2-PEG24|||N6-COOH-miniPEG|||N6-NH2-miniPEG|||N6-NH2-PEG6|||N6-NH2-PEG12|||N6-NH2-PEG24|||N6-COOH-miniPEG|||DRAMP29066|||DRAMP29067 " GFAWNVCVYRNGVRVCHRRAN" Anti-Gram- bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7, activity value is MIC = 0.5||Anti-S. typhimurium ATCC14028, activity value is MIC = 2 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 0.25 ug/ml||Anti-S. pullorum CVCC1789 or CVCC1802, activity value is MIC = 0.5 ug/ml||Anti-S. choleraesuis CV, activity value is CC50 = 3||Anti-P. aeruginosa CICC10419 or CICC21630, activity value is MIC = 4||Anti-S. aureus ATCC43300 MRSA or ATCC25923, activity value is MIC = 0.25||Anti-S. suis CVCC606, activity value is MIC = 16 ug/ml||Anti-E. faecium CMCC1.2136, activity value is MIC = 4 ug/ml||Anti-B. subtilis ATCC6633, activity value is MIC = 0.5 ug/ml||Anti-C. albicans CGMCC2.2411, activity value is MIC = 64 ug/ml||Anti-Escherichia coli CVCC195, activity value is MIC = 0.5 ug/ml||Anti-E. coli CVCC1515, activity value is MIC = 1 ug/ml||Anti-E. coli CICC21530, activity value is MIC = 0.5 ug/ml||Anti-Salmonella typhimurium ATCC14028, activity value is MIC = 2 ug/ml||Anti-S. pullorum CVCC1789, activity value is MIC = 0.5 ug/ml||Anti-S. pullorum CVCC1802a, activity value is MIC = 0.5 ug/ml||Anti-Pseudomonas aeruginosa CICC10419, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa CICC21630, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 16 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 0.25 ug/ml||Anti-S. suis CVCC606, activity value is MIC = 6 ug/ml||Anti-Enterococcus faecium CMCC1.2136, activity value is MIC = 4 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 0.5 ug/ml||Anti-Candida albicans CGMCC2.2411, activity value is MIC = 64 ug/ml||Antibacterial||Antifungal||Anti-E. coli CVCC195, activity value is MIC = 16 ug/ml||Anti-S. typhimurium ATCC14028, activity value is MIC = 16 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 16 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa CICC21630, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 128 ug/ml||Anti-S. typhimurium ATCC14028, activity value is MIC = 32 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa CICC21630, activity value is MIC = 128 ug/ml||Anti-E. coli CVCC195, activity value is MIC = 32 ug/ml||Anti-S. typhimurium ATCC14028, activity value is MIC = 64 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 32 ug/ml||Anti-E. coli CVCC195, activity value is MIC = 128 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 128 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 128 ug/ml||Anti-E. coli CVCC195, activity value is MIC = 8 ug/ml||Anti-S. typhimurium ATCC14028, activity value is MIC = 8 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 64 ug/ml||Anti-Edwardsiella tarda, activity value is MIC = 6.4 ug/ml||Anti-Aeromonas veronii, activity value is MIC = 6.4 ug/ml||Anti-E. coli CVCC25922, activity value is MIC = 0.25 ug/ml||Anti-E. coli CVCCO157, activity value is MIC = 0.5 ug/ml||Anti-Salmonella typhimurium CVCC533, activity value is MIC = 1 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 0.5 ug/ml||Anti-Pseudomonas aeruginosa CICC21630, activity value is MIC = 4 ug/ml||Anti-S. aureus ATCC546, activity value is MIC = 4 ug/ml||Anti-S. hyicus 437-2, activity value is MIC = 64 ug/ml||Anti-S. hyicus 15095, activity value is MIC = 16 ug/ml||Anti-Edwardsiella tarda, activity value is MIC = 0.5 ug/ml||Anti-Aeromonas veronii, activity value is MIC = 2 ug/ml||Anti-Escherichia coli CVCC195, activity value is MIC = 0.06 ug/ml||Anti-E. coli CVCC1515, activity value is MIC = 0.06 ug/ml||Anti-E. coli CVCC25922, activity value is MIC = 0.06 ug/ml||Anti-E. coli CVCCO157, activity value is MIC = 0.06 ug/ml||Anti-Salmonella typhimurium CVCC533, activity value is MIC = 0.25 ug/ml||Anti-S. typhimurium ATCC14028, activity value is MIC = 0.06 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 0.06 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 0.25 ug/ml||Anti-S. pullorum CVCC1789, activity value is MIC = 0.06 ug/ml||Anti-Pseudomonas aeruginosa CICC21630, activity value is MIC = 0.06 ug/ml||Anti-S. aureus ATCC546, activity value is MIC = 1 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 1 ug/ml||Anti-S. hyicus 437-2, activity value is MIC = 16 ug/ml||Anti-S. hyicus 15095, activity value is MIC = 4 ug/ml amino acid substitution, animal-derived, natural derivative|||amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Arenicola marina [Lugworm]|||Synthetic construct Beta||β-turn, coil and antiparallel sheet "N1: At a concentration of 128 µg/ml, hemolysis is 3%. N2: At a concentration of 128 µg/ml, hemolysis is 0.4%; at a concentration of 256 µg/ml, hemolysis is 3.8%. N6: At a concentration of 128 µg/ml, hemolysis is 0.04%; at a concentration of 256 µg/ml, hemolysis is 1.9%.|||At a concentration of 128 µg/mL, the hemolysis rate of mouse red blood cells was 0.4%; at a concentration of 256 µg/mL, the hemolysis rate was 3.8%. At a concentration of N6:128 µg/mL, the hemolysis rate of mouse red blood cells was 0.04%; at a concentration of 256 µg/mL, the hemolysis rate was 1.9%. At a concentration of 32 µg/mL, the parent peptide N1 exhibited a hemolysis rate of 3% (for comparative reference).|||E. coli CVCC195 (MIC= 16 ug/ml), S. typhimurium ATCC14028 (MIC= 16 ug/ml), S. pullorum CVCC1802 (MIC= 16 ug/ml), S. enteritidis CVCC3377 (MIC= 16 ug/ml), P. aeruginosa CICC21630 (MIC= 64 ug/ml), Staphylococcus aureus (ATCC 43300) (MIC= 128 ug/ml), S. hyicus NCTC10350 (MIC= >128 ug/ml), C. albicans CMCC98001 (MIC= >128 ug/ml)|||E. coli CVCC195 (MIC= 16 ug/ml), S. typhimurium ATCC14028 (MIC= 32 ug/ml), S. pullorum CVCC1802 (MIC= 16 ug/ml), S. enteritidis CVCC3377 (MIC= 32 ug/ml), P. aeruginosa CICC21630 (MIC= 128 ug/ml), Staphylococcus aureus (ATCC 43300) (MIC= >128 ug/ml), S. hyicus NCTC10350 (MIC= >128 ug/ml), C. albicans CMCC98001 (MIC= >128 ug/ml)|||E. coli CVCC195 (MIC= 32 ug/ml), S. typhimurium ATCC14028 (MIC= 64 ug/ml), S. pullorum CVCC1802 (MIC= 32 ug/ml), S. enteritidis CVCC3377 (MIC= 32 ug/ml), P. aeruginosa CICC21630 (MIC= >128 ug/ml), Staphylococcus aureus (ATCC 43300) (MIC= >128 ug/ml), S. hyicus NCTC10350 (MIC= >128 ug/ml), C. albicans CMCC98001 (MIC= >128 ug/ml)|||E. coli CVCC195 (MIC= 128 ug/ml), S. typhimurium ATCC14028 (MIC= >128 ug/ml), S. pullorum CVCC1802 (MIC= 128 ug/ml), S. enteritidis CVCC3377 (MIC= 128 ug/ml), P. aeruginosa CICC21630 (MIC= >128 ug/ml), Staphylococcus aureus (ATCC 43300) (MIC= >128 ug/ml), S. hyicus NCTC10350 (MIC= >128 ug/ml), C. albicans CMCC98001 (MIC= >128 ug/ml)|||E. coli CVCC195 (MIC= 8 ug/ml), S. typhimurium ATCC14028 (MIC= 8 ug/ml), S. pullorum CVCC1802 (MIC= 8 ug/ml), S. enteritidis CVCC3377 (MIC= 16 ug/ml), P. aeruginosa CICC21630 (MIC= 64 ug/ml), Staphylococcus aureus (ATCC 43300) (MIC= 64 ug/ml), S. hyicus NCTC10350 (MIC= >128 ug/ml), C. albicans CMCC98001 (MIC= >128 ug/ml)|||Hemolytic activity against Mouse RBCs|||No hemolysis information or data found in the reference(s) presented in this entry|||[Ref.33348729]The hemolysis of N6NH2 towards mouse erythrocytes was 0.19% at a concentration of 256 ug/ml, lower than that of N6 (1.9%), indicating their low hemolytic activity|||murine RBC: 2% hemolysis at 256 ug/ml (low hemo.lytic). Less toxic to RAW264.7 cells than Arenicin-3 analog N1." 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2.|||Sci Rep. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2. PubMed|||28611436|||35549900|||35549900|||Mar Drugs. 2020 Dec 17;18(12):650. doi: 10.3390/md18120650.||Ref.33348729|||Sci Rep. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2. PubMed 21 FPDB01358 AP04720 " FLKIIGKLLSGLL" Anti-Gram+ S. aureus NCTC 6538 or MRSA ATCC 12493, activity value is MIC = 1 uM||Anti-E. faecalis NCTC 12697, activity value is MIC = 2 uM||Anti-E. coli ATCC 8739, activity value is MIC = 8 uM||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 32 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 16 uM||Anti-and yeast C. albicans ATCC 10231, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Hemolytic||Antibiofilm amino acid substitution, insects, animal-derived, natural derivative Helix VM：44.43 uMVM-3K：11.20 uMVM-3G：9.68 uMVM-3W：69.68 uMVM-3Y：221.2 uM|||horse RBC: HC50 11.2 uM, hemolytic|||hj7b02jo9i628j1oolms|||horse RBC: HC50 11.2 uM, hemolytic. 2022 Aug 25;11(9):1263. doi: 10.3390/biology11091263.|||Biology (Basel). 2022 Aug 25;11(9):1263. doi: 10.3390/biology11091263. PubMed|||Biology (Basel). 2022 Aug 25;11(9):1263. doi: 10.3390/biology11091263. PubMed 13 FPDB01362 AP04816|||AP04816|||AP04817 " FLSLIPKAISAVSALAKHL" Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 4 uM||Anti-E. coli ATCC 8739, activity value is MIC = 8 uM||Anti-A.baumannii BAA 747, activity value is MIC > 128 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 32 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm amino acid substitution, amphibian peptide analog, animal-derived, natural derivative Helix PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||horse RBC: HC50 32-64 uM.|||w90c6t7w1sexseowqbf1 https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098.|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI 19 FPDB01363 AP04817 " FLSLIPKAISAVSALAKKL" Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 2||Anti-E. coli ATCC 8739, activity value is MIC = 4 uM||Anti-A. baumannii BAA 747, activity value is MIC = 32 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 16 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 32 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm amino acid substitution, amphibian peptide analog, animal-derived, natural derivative Helix PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||horse RBC: HC50 64 uM.|||w90c6t7w1sexseowqbf1 https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI 19 FPDB01371 AP04833 " FFPKVAGVAAKVAKKIFCTISKKC" Anti-493, activity value is MIC = 4 uM||Anti-697, activity value is MIC = 128 uM||Anti-E. coli ATCC 8739, activity value is MIC = 4 uM||Anti-816, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC CRM 9027, activity value is MIC = 8 uM||Anti-A. baumannii BAA 747, activity value is MIC = 16 uM||Anti-231, activity value is MIC = 32 uM amino acid substitution, amphibians, animal-derived, natural derivative Helix HC₁₀ values: Brevinin-1pl: 8.28 uM [Lys⁴] brevinin-1pl: 13.68 uM [Lys⁴, Ala¹³] brevinin-1pl: 4.59 uM [Lys⁴, Ala¹⁶] brevinin-1pl: 2.51 uM [Lys⁴, Ala¹³,¹⁶] brevinin-1pl: 22 uM des-Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM des-Leu¹³,Ala¹⁶-[Lys⁴] HC₃₀ values: Brevinin-1pl: 37.64 uM [Lys⁴] brevinin-1pl: 80.77 uM [Lys⁴, Ala¹³] brevinin-1pl: 41.34 uM [Lys⁴, Ala¹⁶] brevinin-1pl: 84.86 uM [Lys⁴, Ala¹³,¹⁶] brevinin-1pl: >128 uM des-Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM des-Leu¹³,Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM|||horse RBC: HC50 41.34 uM, hemolytic. 2024 Sep 19:23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. eCollection 2024 Dec.|||Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed|||Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed 24 FPDB01372 AP04834 " FFPKVAGVAAKVLKKAFCTISKKC" Anti-493, activity value is MIC = 4 uM||Anti-697, activity value is MIC = 32 uM||Anti-E. coli ATCC 8739, activity value is MIC = 4 uM||Anti-816, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC CRM 9027, activity value is MIC = 8 uM||Anti-A. baumannii BAA 747, activity value is MIC = 8 uM||Anti-231, activity value is MIC = 32 uM amino acid substitution, amphibians, animal-derived, natural derivative Helix HC₁₀ values: Brevinin-1pl: 8.28 uM [Lys⁴] brevinin-1pl: 13.68 uM [Lys⁴, Ala¹³] brevinin-1pl: 4.59 uM [Lys⁴, Ala¹⁶] brevinin-1pl: 2.51 uM [Lys⁴, Ala¹³,¹⁶] brevinin-1pl: 22 uM des-Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM des-Leu¹³,Ala¹⁶-[Lys⁴] HC₃₀ values: Brevinin-1pl: 37.64 uM [Lys⁴] brevinin-1pl: 80.77 uM [Lys⁴, Ala¹³] brevinin-1pl: 41.34 uM [Lys⁴, Ala¹⁶] brevinin-1pl: 84.86 uM [Lys⁴, Ala¹³,¹⁶] brevinin-1pl: >128 uM des-Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM des-Leu¹³,Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM|||horse RBC: HC50 84.86 uM, hemolytic. 2024 Sep 19:23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. eCollection 2024 Dec.|||Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed 24 FPDB01373 AP04835 " FFPKVAGVAAKVAKKAFCTISKKC" Anti-493, activity value is MIC = 8||Anti-697, activity value is MIC > 128 uM||Anti-E. coli ATCC 8739, activity value is MIC = 16 uM||Anti-816, activity value is MIC = 16 uM||Anti-P. aeruginosa ATCC CRM 9027, activity value is MIC = 32 uM||Anti-A. baumannii BAA 747, activity value is MIC = 32 uM||Anti-231, activity value is MIC = 32 uM amino acid substitution, amphibians, animal-derived, natural derivative Helix HC₁₀ values: Brevinin-1pl: 8.28 uM [Lys⁴] brevinin-1pl: 13.68 uM [Lys⁴, Ala¹³] brevinin-1pl: 4.59 uM [Lys⁴, Ala¹⁶] brevinin-1pl: 2.51 uM [Lys⁴, Ala¹³,¹⁶] brevinin-1pl: 22 uM des-Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM des-Leu¹³,Ala¹⁶-[Lys⁴] HC₃₀ values: Brevinin-1pl: 37.64 uM [Lys⁴] brevinin-1pl: 80.77 uM [Lys⁴, Ala¹³] brevinin-1pl: 41.34 uM [Lys⁴, Ala¹⁶] brevinin-1pl: 84.86 uM [Lys⁴, Ala¹³,¹⁶] brevinin-1pl: >128 uM des-Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM des-Leu¹³,Ala¹⁶-[Lys⁴] brevinin-1pl: >128 uM|||horse RBC: HC50 >128 uM, less hemo.lytic. 2024 Sep 19:23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. eCollection 2024 Dec.|||Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed|||Comput Struct Biotechnol J. 2024 Sep 19;23:3391-3406. doi: 10.1016/j.csbj.2024.09.006. PubMed 24 FPDB01434 AP05428|||DPK-060 " GKHKNKGKKNGKHNGWKWWW" diffusion assay at 100 uM: active against C. albicans ATCC 90028 (7.8 mm)||E. coli ATCC 25922 (9.4 mm)||S. aureus ATCC 29213 (7.2 mm).||Antibacterial Designed, Peptide conjugates|||Homo sapiens Rich GKH17-WWW (3×Trp): At 60 µM, hemolysis of red blood cells ≈ 10%, HaCaT cell penetration < 20%. GKH17-WWWWW (5×Trp): At 60 µM, hemolysis of red blood cells ≈ 40% (comparable to LL-37). In the presence of serum, hemolysis and cytotoxicity of all labeled peptides are reduced to very low levels (< 5%). 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. Epub 2009 Apr 27.|||31192163|||J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB01440 AP05553|||DRAMP35858 " GLLGKILGAGKKVLLGVSGLL" Anti-493 or B038 V1S1A or B042 V2E1A, activity value is MIC = 4||Anti-697, activity value is MIC > 512 uM||Anti-S. constellatus B003 VISIT, activity value is MIC = 4 uM||Anti-418, activity value is MIC = 8 uM||Anti-816, activity value is MIC = 8||Anti-853 or ATCC 9097 or B004 V2S2B, activity value is MIC > 256 uM||Anti-and fungus C. albicans NYCY 1467, activity value is MIC = 32 uM||Antimicrobial||Anticancer amino acid substitution, amphibian peptides, animal-derived, natural derivative|||Synthetic Helix Nigrocin-PN: At the highest tested concentration of 512 µM, it shows limited hemolysis. Nigrocin-M1: Due to the absence of the disulfide bond, the hemolytic index is significantly increased. Nigrocin-M2: After the complete removal of the 'Rana box,' hemolysis is reduced, especially at concentrations above 100 µM.|||~20% hemo.lytic at 100 uM (HC50>100 uM). 2022 May 23;20(1):76. doi: 10.1186/s43141-022-00366-9.|||J Genet Eng Biotechnol. 2022 May 23;20(1):77.|||J Genet Eng Biotechnol. 2022 May 23;20(1):76. doi: 10.1186/s43141-022-00366-9. PubMed 21 FPDB01456 AP02603|||AP02603|||VpAmp1.0|||VpAmp1.0|||AP02603 LPFFLLSLIPSAISAIKKI Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-TB||Hemolytic||Antibacterial ; Synthetic construct||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2.5 uM||Anti-Streptococcus agalactiae, activity value is MIC = 2.5 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 24 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 2.5 uM||Anti-Candida albicans, activity value is MIC = 6.25 uM||Anti-Candida glabrata, activity value is MIC > 50 uM||Anti-Mycobacterium tuberculosis H37Rv, activity value is MIC = 17.4||Anti-Mycobacterium tuberculosis, activity value is MIC = 4.8 venom glands, Vaejovis punctatus, Mexico, North America|||Synthetic construct|||venom glands, Vaejovis punctatus, Mexico, North America Helix venom glands, Vaejovis punctatus, Mexico, North America||The cytotoxicity of the peptides was assayed against normal human red blood cells, measuring the extent of hemolysis exerted by different concentrations of the peptides (Figure 3 and Table 3). The only highly hemolytic peptide was VpAmp1.0, eliciting strong hemolysis at relatively low concentrations. The hemolytic effect is reduced in the order VpAmp1.0 >> VpAmp1.1 > VpAmp2.1 > VpAmp2.0, with concentrations producing 50% hemolysis (HC50) of roughly 9, 34, 104 and 171 uM, respectively.|||Staphylococcus aureus ATCC 25923[MIC = 2.5 uM], Streptococcus agalactiae[MIC = 2.5 uM], Escherichia coli ATCC 25922[MIC = 24 uM], Pseudomonas aeruginosa ATCC 9027[MIC = 2.5 uM], Candida albicans[MIC = 6.25 uM], Candida glabrata[MIC >50 uM], Mycobacterium tuberculosis H37Rv[MIC = 17.4+-6.4 uM], Mycobacterium tuberculosis[MIC = 4.8+-1.5 uM]||Human erythrocytes (50% Hemolysis at 9.2+-0.3 uM|||Human erythrocytes (50% Hemolysis at 9.2+-0.3 uM|||Human erythrocytes (50% Hemolysis at 9.2+-0.3 uM|||The only highly hemolytic peptide was VpAmp1.0, eliciting strong hemolysis at relatively low concentrations. The hemolytic effect is reduced in the order VpAmp1.0 >> VpAmp1.1 > VpAmp2.1 > VpAmp2.0, with concentrations producing 50% hemolysis (HC50) of roughly 9, 34, 104 and 170 uM, respectively. "2015 Nov:73:51-9. doi: 10.1016/j.peptides.2015.08.014. Epub 2015 Sep 4.|||Peptides. 2015 Sep 4;73:51-59. PubMed|||https://pubmed.ncbi.nlm.nih.gov/26352292|||26352292|||Peptides . 2015 Nov:73:51-9. doi: 10.1016/j.peptides.2015.08.014. Epub 2015 Sep 4|||Peptides. 2015 Sep 4;73:51-59. PubMed" 19 FPDB01457 AP02604|||AP02604|||VpAmp2.0|||VpAmp2.0|||AP02604 FWGFLGKLAMKAVPSLIGGNKSSSK Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-TB||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10 uM||Anti-Streptococcus agalactiae, activity value is MIC = 15 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 24 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 15 uM||Anti-Candida albicans, activity value is MIC = 12.5 uM||Anti-Candida glabrata, activity value is MIC = 50 uM||Anti-Mycobacterium tuberculosis H37Rv, activity value is MIC = 21.4||Anti-Mycobacterium tuberculosis, activity value is MIC = 30.5 venom glands, Vaejovis punctatus, Mexico, North America|||Synthetic construct|||Synthetic construct|||venom glands, Vaejovis punctatus, Mexico, North America|||venom glands, Vaejovis punctatus, Mexico, North America Helix venom glands, Vaejovis punctatus, Mexico, North America||Human red blood cells were used to evaluate the hemolytic capabil- ity of defensin-TK. It exerted a low hemolytic activity on human red cells. At concentrations of 200, 100 and 50 ug/ml, the hemolysis ratio of human red cells was 6.2%, 2.7% and 1.5%, respectively.|||Human erythrocytes (50% Hemolysis at 167+-22.5 uM|||Human erythrocytes (50% Hemolysis at 167+-22.5 uM|||The only highly hemolytic peptide was VpAmp1.0, eliciting strong hemolysis at relatively low concentrations. The hemolytic effect is reduced in the order VpAmp1.0 >> VpAmp1.1 > VpAmp2.1 > VpAmp2.0, with concentrations producing 50% hemolysis (HC50) of roughly 9, 34, 104 and 170 uM, respectively. "2015 Nov:73:51-9. doi: 10.1016/j.peptides.2015.08.014. Epub 2015 Sep 4.|||Peptides. 2015 Sep 4;73:51-59. PubMed|||26352292|||26352292|||Peptides . 2015 Nov:73:51-9. doi: 10.1016/j.peptides.2015.08.014. Epub 2015 Sep 4.|||Peptides. 2015 Sep 4;73:51-59. PubMed" 25 FPDB01468 AP00027 RRWWRF Anti-S. aureus, activity value is IC50 = 5 ug/ml||Anti-S. sanguis, activity value is IC50 = 5 ug/ml||Anti-E. coli, activity value is IC50 = 8 ug/ml||Anti-and C. albicans, activity value is IC50 = 39 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis Synthetic Combinatorial peptide Library, designed, man-made sequences|||Synthetic Combinatorial peptide Library, Nonhelixbeta A series of hexapeptides were tested for hemolytic activity on human red blood cells. The results showed that at a concentration of 100 µg/ml, most peptides with significant antibacterial or antifungal activity had hemolysis rates below 5%. Among them, Ac-RRWWCM-NH₂ and Ac-RRWWCW-NH₂ had hemolysis rates of 9.5% and 47–50%, respectively, while other highly active peptides such as Ac-RRWWCF-NH₂ and Ac-RRWWCL-NH₂ had hemolysis rates between 0–5% (detailed data are shown in Table 1). "1995 Jan;78(1):39-46. doi: 10.1111/j.1365-2672.1995.tb01671.x.|||Comparative Study J Appl Bacteriol . 1995 Jan;78(1):39-46. doi: 10.1111/j.1365-2672.1995.tb01671.x.|||J Appl Bacteriol. 1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.|||J Appl Bacteriol 1995; 78: 39-46. PubMed." 6 FPDB01477 AP00678|||AP00678|||Cathelicidin|||DRAMP02925|||Cathelicidin|||AP00678 RLKELITTGGQKIGEKIRRIGQRIKDFFKNLQPREEKS "Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis||anti-sepsis Crucial residues:||Antibacterial||Anti-Escherichia coli, activity value is MIC = 1.25 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 1.25 uM||Anti-Salmonella serotype Typhimurium, activity value is MIC = 1.25 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 1.25 uM||Anti-Proteus mirabilis, activity value is MIC = 1.25 uM||Anti-Salmonella serotype Enteritidis, activity value is MIC = 0.5 uM||Anti-Neisseria gonorrhoeae, activity value is MIC = 0.06 uM||Anti-Staphylococcus aureus, activity value is MIC = 50 uM||Anti-Candida albicans ATCC 11006, activity value is MIC = 44.33 uM||Anti-Candida albicans ATCC 14053, activity value is MIC = 11.08 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1.11 uM||Anti-Escherichia coli ATCC 700336, activity value is MIC = 1.11 uM||Anti-Escherichia coli ATCC 700378, activity value is MIC = 1.11 uM||Anti-Escherichia coli ATCC BAA-457, activity value is MIC = 1.11 uM||Anti-Klebsiella pneumoniae ATCC 10031, activity value is MIC = 1.11 uM||Anti-Proteus mirabilis ATCC 12453, activity value is MIC = 1.11 uM||Anti-Pseudomonas aeruginosa ATCC 10145, activity value is MIC = 1.11 uM||Anti-Salmonella Enteritidis ATCC 13076, activity value is MIC = 0.44 uM||Anti-Salmonella Typhimurium ATCC 13311, activity value is MIC = 1.11 uM||Anti-Neisseria gonorrhoeae ATCC 10150, activity value is MIC = 0.06 uM||Anti-Staphylococcus aureus ATCC 10832, activity value is MIC = 44.33 uM||Anti-Listeria monocytogenes ATCC 19115, activity value is MIC = 0.44 uM||Anti-Ureaplasma canigenitalium ATCC 51252, activity value is MIC = 0.06 uM||Anti-Ureaplasma urealyticum ATCC 27619, activity value is MIC = 44.33 uM" Dog|||Dog|||Canis lupus familiaris [Dog]|||Canis lupus familiaris (Dog)|||Canis lupus familiaris [Dog]|||Dog N/A At a concentration of 100 μM, K9CATH caused less than 5% hemolysis of human, dog, and chicken red blood cells. By comparison, the bovine-derived cathelicidin fragment BMAP-28 (1-18) caused approximately 20%, 25%, and 30% hemolysis of chicken, dog, and human red blood cells, respectively, at the same concentration.|||The document mentions that K9CATH, at concentrations up to 100 μM, causes less than 5% hemolysis in dog, human, and chicken red blood cells, showing extremely low hemolytic activity. In contrast, the positive control, bovine bone marrow antimicrobial peptide BMAP-28 (1-18), at 100 μM, causes approximately 20%, 25%, and 30% hemolysis in chicken, dog, and human red blood cells, respectively.|||K9CATH exhibits very low hemolytic activity against human, canine, and chicken red blood cells, with hemolysis rates of less than 5% at a concentration of 100 μM. The positive control, bovine bone marrow antimicrobial peptide BMAP-28 (1-18), at 100 μM, shows hemolysis rates of approximately 20%, 25%, and 30% against chicken, canine, and human red blood cells, respectively. Compared to BMAP-28, K9CATH has 10-20 times lower in vitro hemolytic activity against canine and chicken red blood cells. Dev Comp Immunol 2007; 31:1278-96.|||Dev Comp Immunol 2007; 31:1278-96.|||17462733|||Dev Comp Immunol. 2007;31(12):1278-1296.|||17462733|||Dev Comp Immunol 2007; 31:1278-96. 38 FPDB01480 AP00945|||AP00945|||OP-145 IGKEFKRIVERIKRFLRELVRPLR Anti-24 h incubation: Active against E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 3 uM||Anti-C. albicans ATCC 10231, activity value is MIC = 6 uM||Anti-and A. niger ATCC 14406, activity value is MIC = 18 uM||Antibacterial||Antibiofilm||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis peptide library screen, human cathelicidin analog, animal-derived, natural derivative|||peptide library screen, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct N/A N/A 2006 Apr;27(4):649-60. doi: 10.1016/j.peptides.2005.09.016. Epub 2005 Nov 7.||see ref|||2006 Apr;27(4):649-60. doi: 10.1016/j.peptides.2005.09.016. Epub 2005 Nov 7.||see ref|||26525663, 28890511|||Peptides. 2006 Apr;27(4):649-60. doi: 10.1016/j.peptides.2005.09.016. PubMed.|||Peptides. 2006 Apr;27(4):649-60. doi: 10.1016/j.peptides.2005.09.016. PubMed.||see ref 24 FPDB01482 AP01475 ECWMDGHCRLLCKDGEDSIIRCRNRKRCC Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis pooled fetal lung, testis, B-cell, Homo sapiens|||pooled fetal lung, testis, B-cell, Homo sapiens Bridge "The document mentions the following values related to hemolysis: DEFB120: At concentrations up to 250 μg/ml, the hemolysis rate of human red blood cells is less than 10%, showing no significant hemolytic activity. LL37 (positive control): At a concentration of 250 μg/ml, the hemolysis rate of human red blood cells is approximately 35%.|||Many antimicrobial peptides (AMPs) tend to have cytotoxicity. Therefore, it is expected to detect cytotoxic and hemolytic activities of DEFBs working as ideal candidates against pathogenic microorganisms. To evaluate the hemolytic effect of the recombinant DEFB120 peptide, the released hemoglobin from erythrocytes was tested. Erythrocytes were incubated with different concentrations of the DEFB120 peptide in the range of 10–250 ug/ml for 1h at 37 °C. As a positive control, LL37 was tested in the same way. Under these conditions, LL37 exhibited prominent hemolytic activity with concentration dependence, whereas DEFB120 showed no significant hemolytic effect up to 250 ug/ml (Figure 7)." 2014 Apr;20(4):251-7. doi: 10.1002/psc.2611. Epub 2014 Jan 21.|||J Pept Sci. 2014 Apr;20(4):251-7. Pub-Med. 29 FPDB01491 AP01751|||Papiliocin|||AP01751|||DRAMP04577 RWKIFKKIEKVGRNVRDGIIKAGPAVAVVGQAATVVK Anti-it is especially active against Gram-negative bacteria. Active against Gram- E. coli, activity value is MIC = 0.25 uM||Anti-S. typhimurium, activity value is MIC = 0.5 uM||Anti-P. aeruginosa, activity value is MIC = 1.0 um||Anti-S. aureus, activity value is MIC = 32 uM||Anti-B. subtilis, activity value is MIC = 16 uM||Anti-and S. epidermidis, activity value is MIC = 2 uM||Antibacterial||Antifungal||No MICs found in DRAMP database||Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis the swallowtail butterfly, Papilio xuthus|||the swallowtail butterfly, Papilio xuthus|||Papilio xuthus [Asian swallowtail butterfly]|||the swallowtail butterfly, Papilio xuthus|||Papilio xuthus Helix "At concentrations of 50 μM, 25 μM, 12.5 μM, 6.25 μM, and 3.13 μM, the hemolysis rate of human red blood cells by Papiliocin was 0%.|||Researchers conducted hemolytic activity assays on human red blood cells using synthetic papiliocin, with melittin from bee venom serving as a positive control. At different concentrations, the hemolysis rates of the two peptides are as follows: -Papiliocin: At concentrations of 50 µM, 25 µM, 12.5 µM, 6.25 µM, and 3.13 µM, the hemolysis rate was 0% in all cases. -Melittin: At concentrations of 50 µM, 25 µM, 12.5 µM, and 6.25 µM, the hemolysis rate was 100% in each case; at a concentration of 3.13 µM, the hemolysis rate was 98%.|||No hemolysis information or data found in the reference(s) presented in this entry|||Not hemo.lytic at 100 uM" "2010 Apr;29(4):419-23. doi: 10.1007/s10059-010-0050-y. Epub 2010 Mar 4|||Mol Cells . 2010 Apr;29(4):419-23. doi: 10.1007/s10059-010-0050-y. Epub 2010 Mar 4.|||20213310|||Mol Cells. 2010 Apr;29(4):419-23. PubMed|||Mol Cells. 2010 Apr;29(4):419-423.|||Mol Cells. 2010 Apr;29(4):419-23. PubMed" 37 FPDB01493 AP02138|||AP02140|||AP02138|||Oreoch-1|||Oreoch-1|||AP02138|||AP02138 FIHHIIGGLFSVGKHIHGLIHGH Anti-S. aureus, activity value is MIC = 5 uM||Anti-B. subtilis, activity value is MIC = 3 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||anti-sepsis gills, tilapia, Oreochromis niloticus|||Oreochromis niloticus [Nile tilapia] N/A "TP1 and TP5 showed no hemolytic activity at a concentration of 100 µg/ml. TP2 had a hemolysis rate of 60% at a concentration of 40 µg/ml. TP3 had a hemolysis rate of 42% at a concentration of 100 µg/ml. TP4 had a hemolysis rate of 100% at a concentration of 100 µg/ml.|||gills, tilapia, Oreochromis niloticus||HC₅₀ = 10 uM。|||Synthetic piscidin-like peptides were assays for hemolytic activity in human and fish red blood cells. Oreoch-1 and Oreoch-3 were not hemo- lytic forhuman red blood cells at concentrations below55 uM. Incontrast, Oreoch-2 was hemolytic in human erythrocytes reaching 50% ofhemoly- sis at 19 uM(Fig. 7A). In addition, hemolytic activity in fish red blood cells was observed for Oreoch-1 and Oreoch-2 above 16 uMand 7 uMrespec- tively, in a dose-dependent manner. Oreoch-1 and Oreoch-2 reached 23% and 57% ofhemolysis, respectively, at the highest concentration analyzed (Fig. 7B). In contrast, Oreoch-3 was not hemolytic for fish erythrocytes at concentrations below 55 uM(Fig. 7B)." 2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30.|||Aquaculture 2013; 372–375;9–18.|||Reference: Acostaa J, Monterob V, Carpioa Y, Velázqueza J, Garayc HE, Reyesc O, Cabralesc A, Masforrolc Y, Moralesa A, Estrada MP (2013) Cloning and functional characterization of three novel antimicrobial peptides from tilapia (Oreochromis niloticus). A|||Reference: Acostaa J, Monterob V, Carpioa Y, Velázqueza J, Garayc HE, Reyesc O, Cabralesc A, Masforrolc Y, Moralesa A, Estrada MP (2013) Cloning and functional characterization of three novel antimicrobial peptides from tilapia (Oreochromis niloticus). A|||Aquaculture 2013; 372–375;9–18. Sci Direct.|||Aquaculture 2013; 372–375;9–18. Sci Direct. 23 FPDB01494 AP02182|||AP02182|||Beta-defensin114|||DRAMP03613 DRCTKRYGRCKRDCLESEKQIDICSLPRKICCTEKLYEEDDMF Active against E. coli||S. aureus||and C. albicans. Activity is salt-sensitive. In addition||this human beta defensin protects sperm from motility loss.||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis||Antibacterial||Antimicrobial epididymis and gingival cells , Homo sapiens|||Homo sapiens [Human]|||epididymis and gingival cells , Homo sapiens|||Homo sapiens (Human) Bridge epididymis and gingival cells , Homo sapiens||DEFB114 has no obvious hemolytic effect on human red blood cells at a concentration of 100 ug/ml. "Vet. Immunol. Immunopathol. 106 (3-4), 321-327 (2005)|||J Biol Chem. 2013 Apr 26;288(17):12270-82. Pub-Med.|||85540943|||J Biol Chem . 2013 Apr 26;288(17):12270-82. doi: 10.1074/jbc.M112.411884. Epub 2013 Mar 12.|||Physiol Genomics. 2005 Sep 21;23(1):5-17.Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2129-33.|||J Biol Chem. 2013 Apr 26;288(17):12270-82. Pub-Med." 43 FPDB01495 AP02202|||DRAMP18489 RKCNFLCKLKEKLRTVITSHIDKVLRPQG Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory||anti-sepsis||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 2.74 uM Skin secretions; frog, Paa yunnanensis, Yunnan, China, Asia|||Paa yunnanensis(Chinese Yunnan frog) Helix At concentrations of 12.5 µg/mL, 25 µg/mL, and 50 µg/mL, the hemolysis rates in human red blood cells were 2.5%, 3.5%, and 5.5%, respectively.|||Skin secretions; frog, Paa yunnanensis, Yunnan, China, Asia||At a concentration of 12.5 ug/ml, it induces 2.5% hemolysis of human red blood cells; at 25 ug/ml, the hemolysis rate is 3.5%; and at 50 ug/ml, it is 5.5%.|||[Ref.23594231]2.5% hemolytic activity at 12.5 ug/ml, 3.5 hemolytic activity at 25 ug/ml, 5.5% hemolytic activity at 50 ug/ml against human red blood cells "2013 May 9;56(9):3546-56. doi: 10.1021/jm4004158. Epub 2013 Apr 29.|||J Med Chem. 2013 May 9;56(9):3546-56. Pub-Med.|||J Med Chem . 2013 May 9;56(9):3546-56. doi: 10.1021/jm4004158. Epub 2013 Apr 29.|||Ref.23594231|||J Med Chem. 2013 May 9;56(9):3546-56.||Ref.23594231" 29 FPDB01498 AP02241 KYALMKKIAELIPNLKSRQVK Anti-Gram+ & Gram-||Antifungal||candidacidal centipede, Scolopendra subspinipes mutilans, Asia N/A centipede, Scolopendra subspinipes mutilans, Asia||Within the concentration range (0–320 ug/ml), there is no obvious hemolytic effect on rat red blood cells, and the hemolysis rate remains 0%. "2013 Oct 28;23(10):1381-5. doi: 10.4014/jmb.1306.06013.|||J Microbiol Biotechnol. 2013 Oct 28;23(10):1381-5. Pub-Med.|||J Microbiol Biotechnol . 2013 Oct 28;23(10):1381-5. doi: 10.4014/jmb.1306.06013." 21 FPDB01503 AP02569|||AP02569|||Hc-CATH|||DRAMP29102|||Hc-CATH|||AP02569|||DRAMP29102 KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL Anti-E. coli ATCC25922, activity value is MIC = 0.64 uM||Anti-K. oxytoca, activity value is MIC = 1.3 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 5.2||Anti-E. tarda, activity value is MIC = 0.64 uM||activity value is MIC = 1.3||Anti-and V. anguillarum . This peptide also showed good activity against aquatic bacteria Gram- V. alginolyticus, activity value is MIC = 2.59 uM||Anti-V. brasiliensis, activity value is MIC = 1.29 uM||Anti-V. cholerae, activity value is MIC = 0.64 uM||Anti-V. harveyi, activity value is MIC = 1.29 uM||Anti-V. parahaemolyticus, activity value is MIC = 0.64 uM||Anti-V. splendidus, activity value is MIC = 1.29 uM||Anti-V. vulnificus, activity value is MIC = 2.59 uM||Anti-A. hydrophila, activity value is MIC = 1.29 uM||Anti-A. sobria, activity value is MIC = 2.59 uM||Anti-A.veronii, activity value is MIC = 2.59 uM||Anti-and N. asteroides, activity value is MIC = 1.29||Anti-E. coli ATCC25922, activity value is MIC = 2.34 ug/ml||Anti-E. coli 1 Clinically isolated strain, activity value is MIC = 2.34 ug/ml||Anti-E. coli 2, activity value is MIC = 2.34 ug/ml||Anti-E. coli 3, activity value is MIC = 2.34 ug/ml||Anti-E. coli 4, activity value is MIC = 2.34 ug/ml||Anti-S. dysenteriae, activity value is MIC = 0.59 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 18.75 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 4.69 ug/ml||Anti-C. albicans 1 Clinically isolated strain, activity value is MIC = 4.69 ug/ml||Anti-A. hydrophila, activity value is MIC = 2.34 ug/ml||Anti-V. parahaemdyticus, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae 2, activity value is MIC = 4.69 ug/ml||Anti-K. pneumoniae 3, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae 4, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae 5, activity value is MIC = 18.75 ug/ml||Anti-K. pneumoniae 6, activity value is MIC = 37.5 ug/ml||Anti-K. pneumoniae 7, activity value is MIC = 37.5 ug/ml||Anti-K. pneumoniae 8, activity value is MIC = 75 ug/ml||Anti-Klebsiella oxytoca, activity value is MIC = 4.69 ug/ml||Anti-Proteus mirabilis, activity value is MIC = 4.69 ug/ml||Anti-S. maltophilia 2, activity value is MIC = 9.38 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 18.75 ug/ml||Anti-P. aeruginosa 1, activity value is MIC = 37.5 ug/ml||Anti-Salmonella paratyphi A, activity value is MIC = 4.69 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 4.69 ug/ml||Anti-S. aureus 4, activity value is MIC = 4.69 ug/ml||Anti-S. aureus 5, activity value is MIC = 4.69 ug/ml||Anti-Bacillus cereus, activity value is MIC = 9.38 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 75 ug/ml||Anti-Enterococcus faecium, activity value is MIC = 37.5 ug/ml||Anti-Nocardia asteroides, activity value is MIC = 9.38 ug/ml||Anti-Candida albicans 1, activity value is MIC = 4.69 ug/ml||Anti-C. albicans 2, activity value is MIC = 4.69 ug/ml||Anti-C. albicans 3, activity value is MIC = 4.69 ug/ml||Anti-C. albicans 4, activity value is MIC = 4.69 ug/ml||Anti-C. albicans 5, activity value is MIC = 2.34 ug/ml||Anti-C. albicans 6, activity value is MIC = 2.34 ug/ml||Anti-Candida glabrata 1, activity value is MIC = 2.34 ug/ml||Anti-Arcyria cinerea, activity value is MIC = 9.38 ug/ml||Anti-Aeromonas sobria, activity value is MIC = 2.34 ug/ml||Anti-Aeromonas hydrophila, activity value is MIC = 2.34 ug/ml||Anti-Aeromonas veronii, activity value is MIC = 2.34 ug/ml||Anti-Vibrio vulnificus, activity value is MIC = 4.69 ug/ml||Anti-Vibrio harveyi, activity value is MIC = 9.38 ug/ml||Anti-Vibrio fluvialis, activity value is MIC = 4.69 ug/ml||Anti-Vibrio alginolyticus, activity value is MIC = 4.69 ug/ml||Anti-Vibrio parahaemdyticus, activity value is MIC = 9.38 ug/ml||Anti-Vibrio splendidus, activity value is MIC = 2.34 ug/ml||Anti-Vibrio anguillarum, activity value is MIC = 18.75 ug/ml||Anti-Edwardsiella tarda, activity value is MIC = 2.34 ug/ml||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-inflammatory||anti-sepsis||Antibiofilm||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.34 ug/ml||activity value is MIC = 4.69 ug/ml||Anti-Escherichia coli 1, activity value is MIC = 2.34 ug/ml||Anti-Escherichia coli 2, activity value is MIC = 2.34 ug/ml||Anti-Escherichia coli 3, activity value is MIC = 2.34 ug/ml||Anti-Escherichia coli 4, activity value is MIC = 9.38 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 0.59 ug/ml||Anti-Klebsiella pneumoniae 1, activity value is MIC = 37.5 ug/ml||Anti-Klebsiella pneumoniae 2, activity value is MIC = 4.69 ug/ml||Anti-Klebsiella pneumoniae 3, activity value is MIC = 9.38 ug/ml||Anti-Klebsiella pneumoniae 4, activity value is MIC = 9.38 ug/ml||Anti-Klebsiella pneumoniae 5, activity value is MIC = 18.75 ug/ml||Anti-Klebsiella pneumoniae 6, activity value is MIC = 37.5 ug/ml||Anti-Klebsiella pneumoniae 7, activity value is MIC = 37.5 ug/ml||Anti-Klebsiella pneumoniae 8, activity value is MIC = 75 ug/ml||Anti-Serratia marcescens, activity value is MIC > 200 ug/ml||Anti-Proteus vulgaris, activity value is MIC > 200 ug/ml||Anti-Acinetobacter baumannii 1, activity value is MIC > 200 ug/ml||Anti-Acinetobacter baumannii 2, activity value is MIC > 200 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC > 200 ug/ml||Anti-Stenotrophomonas maltophilia 2, activity value is MIC = 9.38 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 18.75 ug/ml||Anti-Pseudomonas aeruginosa 1, activity value is MIC = 37.5 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.69 ug/ml||Anti-Staphylococcus aureus 1, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus 2, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus 3, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus 4, activity value is MIC = 4.69 ug/ml||Anti-Staphylococcus aureus 5, activity value is MIC = 4.69 ug/ml||Anti-Enterococcus faecalis, activity value is MIC > 200 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC > 200 ug/ml||Anti-Candida albicans 2, activity value is MIC = 4.69 ug/ml||Anti-Candida albicans 3, activity value is MIC = 4.69 ug/ml||Anti-Candida albicans 4, activity value is MIC = 4.69 ug/ml||Anti-Candida albicans 5, activity value is MIC = 2.34 ug/ml||Anti-Candida albicans 6, activity value is MIC = 2.34 ug/ml||Anti-Candida glabrata, activity value is MIC > 200 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC > 200 ug/ml||Anti-Pathogenic bacteria:Aeromonas sobria, activity value is MIC = 2.34 ug/ml||Anti-Vibrio parahaemolyticus, activity value is MIC = 9.38 ug/ml||Anti-##Gram-positive bacteria:Staphylococcus aureus ATCC 25923, activity value is MIC = 4.69 ug/ml||Anti-##Fungi:Candida albicans 1, activity value is MIC = 4.69 ug/ml||Anti-##Pathogenic bacteria:Aeromonas sobria, activity value is MIC = 2.34 ug/ml venom gland, spleen, and lung, annulated sea snake, Hydrophis cyanocinctus, Asia|||Hydrophis cyanocinctus [Asian annulated sea snake ]|||venom gland, spleen, and lung, annulated sea snake, Hydrophis cyanocinctus, Asia|||Hydrophis cyanocinctus|||Hydrophis cyanocinctus [Asian annulated sea snake ]|||venom gland, spleen, and lung, annulated sea snake, Hydrophis cyanocinctus, Asia|||Hydrophis cyanocinctus Helix||Alpha helix,β-sheet,random coil "venom gland, spleen, and lung, annulated sea snake, Hydrophis cyanocinctus|||Human erythrocytes ( 5.25% at 200 ug/ml )|||The document explicitly provides the hemolytic values of sea snake cathelicidin (Hc-CATH), with specific information as follows: At a concentration of 200 μg/ml (approximately 55.12 μM, which is nearly 10 times the MIC value against most tested microorganisms), Hc-CATH has a hemolysis rate of 5.25% on human red blood cells. This data was determined through a hemolysis assay: 1% Triton X-100 (v/v) was used as the 100% hemolysis positive control, 0.9% physiological saline as the negative control, and the hemolysis rate of Hc-CATH at different concentrations was recorded. At a concentration of 200 μg/ml, the hemolysis rate was 5.25%, demonstrating its low hemolytic activity on mammalian red blood cells.|||The hemolytic value of Hc-CATH is: at a concentration of 200 µg/ml (55.12 µM), the hemolysis rate of human red blood cells is 5.25%.|||Human erythrocytes ( 5.25% at 200 ug/ml )|||HC-Cath has very low cytotoxicity to the tested mammalian cells. At a concentration of 200 μg/ml (55.12 μM, nearly 10 times higher than the MIC for most tested microorganisms), the cell death rates induced by HC-Cath were 4.70%, 3.63%, 1.30%, and 4.28%, respectively. In terms of hemolytic activity, the hemolysis rate of HC-Cath was 5.25% at the same concentration of 200 μg/ml. The adsorption and attachment of HC-CathBin to bacteria are the first steps of AMP-mediated cell killing.|||[Ref.26013823]5.25% Hemolysis against Human erythrocytes at 200 ug/ml(55.12 uM).|||Cytotoxicity and Hemolysis of Hc-CATH—As shown in Table6,Hc-CATH exhibited very low cytotoxicity toward the tested mammalian cells.At concentrations up to200 ug/ml(55.12u M,nearly 10-fold high than the MICs of most tested microorganisms), Hc-CATH induced cell death per-centages as low as 4.70, 3.63, 1.30, and 4.28% for HepG2, PC3,L929,and mouse peritoneal macrophage cells,respectively. As to hemolytic activity,Hc-CATH yielded a hemo lysis of 5.25%,at the same concentration of 200 ug/ml." "2015 Jul 3;290(27):16633-52. doi: 10.1074/jbc.M115.642645. Epub 2015 May 26||Ouyang et al., 2022||Wang et al., 2022|||J Biol Chem. 2015 Jul 3;290(27):16633-52. PubMed||Ouyang et al., 2022||Wang et al., 2022||He et al., 2022|||26013823|||J Biol Chem. 2015 Jul 3;290(27):16633-52. PubMed|||J Biol Chem. 2015 Jul 3;290(27):16633-52.||Ref.26013823|||26013823|||J Biol Chem . 2015 Jul 3;290(27):16633-52. doi: 10.1074/jbc.M115.642645. Epub 2015 May 26.||Ouyang et al., 2022||Wang et al., 2022||He et al., 2022|||J Biol Chem. 2015 Jul 3;290(27):16633-52.||Ref.26013823|||J Biol Chem. 2015 Jul 3;290(27):16633-52. PubMed" 30 FPDB01513 AP02898|||AP02899|||AP02900|||AP02898|||As-CATH4|||AP02898|||DRAMP32057 RRGLFKKLRRKIKKGFKKIFKRLPPVGVGVSIPLAGRR Active against Gram- bacteria E. coli||S. dysenteriae||K. pneumoniae||K. oxytoca||P. vulgaris||P. mirabilis||A. baumannii||S. maltophilia||and P. aeruginosa||Gram+ bacteria S. aureus||B. cereus||E. faecium||and S. epidermidis||and fungi C. albicans. Also active against aquatic pathogenic bacteria A. sobria||A. hydrophila||A. veronii||V. harveyi||V. parahaemdyticus||V. anguillarum||and V. cholerae. Antibacterial activity appears to be salt-resistant (salt-insensitive). At a high concentration of 200 ug/ml||it showed only 4% hemolysis (human red blood cells).||Antibacterial||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis Chinese alligator, Alligator sinensis|||Alligator sinensis|||Chinese alligator, Alligator sinensis Helix Chinese alligator, Alligator sinensis||As shown in Table 5, As-CATH4~6 exhibited selective cytotoxicity toward the tested mammalian cells. Among the three tested cells, CHO cell were the most sensitive to As-CATH4~6. At a concentration of 200 ug/ml, As-CATH4~6 induced CHO death rates of 55%, 89% and 89%, respectively. Among the three peptides, As-CATH4 was the least cytotoxic. At a concentration of 200 ug/ml, As-CATH4 induced death rates of 27%, 55% and 17% for BGC-823, CHO and mouse peritoneal macrophages, respectively. As to hemolytic activity, As-CATH4~6 yielded hemolytic rates of 4%, 47%, and 48% respectively toward human erythrocytes. However, it should be noted that the concentrations of As-CATH4~6 in cytotoxic and hemolytic assays were nearly 10-fold higher than their MICs toward most of the tested microorganisms. At a concentration of 20 ug/ml, the cytotoxic and hemolytic rates induced by As-CATH4~6 significantly decreased to below 10%, suggesting their potential in therapeutic application (data not shown). Unlike As-CATH4~6, As-CATH1~3 didn’t show apparent cytotoxic and hemolytic activities (data not shown).|||Human erythrocytes: 4±0.5% Hemolysis=200 ug/ml|||As to hemolytic activity, As-CATH4~6 yielded hemolytic rates of 4%, 47%, and 48% respectively toward human erythrocytes. However, it should be noted that the concentrations of As-CATH4~6 in cytotoxic and hemolytic assays were nearly 10-fold higher than their MICs toward most of the tested microorganisms. At a concentration of 20 ug/ml, the cytotoxic and hemolytic rates induced by As-CATH4~6 significantly decreased to below 10%, suggesting their potential in therapeutic application (data not shown). Unlike As-CATH4~6, As-CATH1~3 didn’t show apparent cytotoxic and hemolytic activities (data not shown). "2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334.|||Biochem J . 2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334.|||29017942|||Biochem J . 2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334.|||Biochem J. 2017 Aug 10;474(16):2861-2885.|||Biochem J. 2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334. PubMed" 38 FPDB01518 AP03031|||AP03031|||Esculentin-1GN GLFSKKGGKGGKSWIKGVFKGIKGIGKEVGGDVIRTGIEIAACKIKGEC Anti-E. coli ATCC 25922, activity value is MIC = 3.7 uM||Anti-P. aeruginosa, activity value is MIC = 50 uM||Anti-S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant, activity value is MIC = 1.9||Anti-P. acnes, activity value is MIC = 1.17 uM||Anti-S. subtilis ATCC 6633, activity value is MIC = 3.1 uM||Anti-and C. albicans, activity value is MIC = 4.7 uM||Antibacterial||Antifungal ; S.aureus||E. coli||P. aeruginosa||C. albicans||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antioxidant||Anti-inflammatory||anti-sepsis kin, Hylarana guentheri, Asia|||Hylarana guentheri [Günther's frog]|||skin, Hylarana guentheri, Asia|||skin, Hylarana guentheri, Asia Helix "Esculentin-1GN: At a concentration of 40 μM, the hemolysis rate on human red blood cells is only 6.2%.|||skin, Hylarana guentheri, Asia|||The hemolytic ability of hederagenin-1GN was determined using human red blood cells. As shown in Table S5, hederagenin-1GN has a low hemolytic activity on human red blood cells. At a concentration of 40 μM, the hemolysis rate of human red blood cells was only 6.2%.|||In the provided document, the hemolysis-related data for the novel antimicrobial peptide Esculentin-1GN are as follows: - Hemolysis rate: At a concentration of 40 μM, Esculentin-1GN exhibited a hemolysis rate of only 6.2% on human red blood cells, indicating low hemolytic activity. This data was measured through a human red blood cell hemolysis assay, in which hemolysis induced by 0.1% Triton X-100 was used as the 100% control to assess the degree of red blood cell damage (hemoglobin release) at different peptide concentrations.|||As shown in Table S5, Esculentin-1GN showed a low hemolytic activity on human red cells. At concentrations of 40 uM, the hemolysis ratio of human red cells was only 6.2%." "2018 Dec 13;61(23):10709-10723. doi: 10.1021/acs.jmedchem.8b01358. Epub 2018 Nov 27.|||J Med Chem . 2018 Dec 13;61(23):10709-10723. doi: 10.1021/acs.jmedchem.8b01358. Epub 2018 Nov 27.|||30427189|||J Med Chem . 2018 Dec 13;61(23):10709-10723. doi: 10.1021/acs.jmedchem.8b01358. Epub 2018 Nov 27.|||J Med Chem. 2018 Nov 14. 61 (23), 10709-10723. doi: 10.1021/acs.jmedchem.8b01358. PubMed|||J Med Chem. 2018 Nov 14. 61 (23), 10709-10723. doi: 10.1021/acs.jmedchem.8b01358. PubMed" 49 FPDB01521 AP03139|||AP03139|||CAMPSQ10792|||Allomyrinasin|||AP03139 AAVTRRILCWFA Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory||anti-sepsis||Antibacterial the Dynastid Beetle, Aloidendron dichotomum|||Allomyrina dichotoma|||Allomyrina dichotoma|||the Dynastid Beetle, Aloidendron dichotomum|||the Dynastid Beetle, Aloidendron dichotomum N/A the Dynastid Beetle, Aloidendron dichotomum "2019 May 28;29(5):687-695. doi: 10.4014/jmb.1809.09031.|||J Microbiol Biotechnol . 2019 May 28;29(5):687-695. doi: 10.4014/jmb.1809.09031.|||30955257|||30955257|||J Microbiol Biotechnol . 2019 May 28;29(5):687-695. doi: 10.4014/jmb.1809.09031.|||J Microbiol Biotechnol 29 (5), 687-695 2019 May 28. PMID: 30955257 DOI: 10.4014/jmb.1809.09031. PubMed" 12 FPDB01522 AP03151|||AP03151|||NLF20|||NLF20|||AP03151 NLFRKLTHRLFRRNFGYTLR Anti-Gram- P. aeruginosa, activity value is MBC = 30 uM||Anti-E. coli, activity value is MBC < 10 uM||Antibacterial||Antifungal||Antifungal ; E. coli ATCC 25922||P. aeruginosa ATCC 27853||S. aureus ATCC 29213||B. subtilis ATCC 6633||C. albicans ATCC 90028||C. parapsilosis ATCC 90018||Anti-Gram+ & Gram-||candidacidal||Anti-inflammatory||anti-sepsis fragments of a human antimicrobial protein, animal-derived, natural derivatives|||Synthetic construct Helix "At concentrations of 30-60 μM, only slight hemolysis occurs within the standard incubation time, with a hemolysis rate ≤2%; In human blood containing bacteria, the hemolysis rate at concentrations of 30-60 μM still remains ≤2%; After long-term incubation of 18 hours, the hemolysis rate at the highest antibacterial concentration (313 μg/ml) is only 5% (in a 50% blood system).|||fragments of a human antimicrobial protein, animal-derived, natural derivatives" "2016 Jan;71(1):170-80. doi: 10.1093/jac/dkv322. Epub 2015 Oct 26.|||J Antimicrob Chemother . 2016 Jan;71(1):170-80. doi: 10.1093/jac/dkv322. Epub 2015 Oct 26.|||26503666|||26503666|||J Antimicrob Chemother . 2016 Jan;71(1):170-80. doi: 10.1093/jac/dkv322. Epub 2015 Oct 26.|||Biochim Biophys Acta. 2013;1828(11):2709–2719. doi:10.1016/j.bbamem.2013.06.015 PubMed" 20 FPDB01525 AP03227 GIKEFAHSLGKFGKAFFGGILNQ Anti-including C. albicans NCTC 3179, activity value is MIC = 100 uM||Anti-S. mutans ATCC 10449, activity value is MIC = 50 uM||Anti-F. nucleatum NCTC 10562, activity value is MIC = 12.5 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis the octoploid frog, Xenopus amieti (Pipidae)|||the octoploid frog, Xenopus amieti (Pipidae) N/A the octoploid frog, Xenopus amieti (Pipidae)|||Magainin-AM1, magainin-AM2, and PGLa-AM2 dis played very low hemolytic activity (LC50 >200 uM) against human erythrocytes. "2010 Jun;31(6):989-94. doi: 10.1016/j.peptides.2010.03.002. Epub 2010 Mar 10.||see the ref|||Peptides . 2010 Jun;31(6):989-94. doi: 10.1016/j.peptides.2010.03.002. Epub 2010 Mar 10.||see the ref||McLean et al., 2014|||Peptides . 2010 Jun;31(6):989-94. doi: 10.1016/j.peptides.2010.03.002. PubMed" 23 FPDB01526 AP03231|||AP03231|||Brevinin-2SSb|||DRAMP32299 SLFSLIKAGAKFLGKNMLKQGPQYPACKVSKDSENVNWKS Anti-and P. aeruginosa and the fungus C. albicans, activity value is MIC = 30 uM||Antibacterial||Antifungal||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||candidacidal||Antioxidant||anti-sepsis skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Glandirana susurra|||skin, the Sado Wrinkled Frog, Glandirana susurra, Asia N/A skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Monkey COS-7 cells (88.5% Killing at 32 ug/ml "2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457|||Antibiotics (Basel) . 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||32751229|||Antibiotics (Basel) . 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||Antibiotics (Basel). 2020 Jul 29;9(8):457.|||Antibiotics (Basel). 2020 Jul 29;9(8):E457. doi: 10.3390/antibiotics9080457. PubMed" 40 FPDB01527 AP03232|||AP03232|||Ranatuerin-2SSa|||Ranatuerin-2SSa|||AP03232|||DRAMP32298 GLISTIWNTASNVAGTLTDSVKCKFKKC Active against the fungus C. albicans. Ranatuerin-2SSa was slightly active against plant pathogen C. michiganensis subsp. michiganensis. Moderate antioxidant activity (20 ug/ml at 21.9%).||Escherichia coli JCM 5491||Salmonella enterica JCM 1652[20-30% Inhibition = 128 ug/ml]||Pseudomonas aeruginosa JCM 6119[20-30% Inhibition = 128 ug/ml]||Staphylococcus aureus JCM 2874||Bacillus cereus JCM 2152||Candida albicans JCM 2085[70-80% Inhibition = 128 ug/ml]||Xanthomonas oryzae pv. oryzae MAFF 311018||Clavibacter michiganensis subsp. michiganensis MAFF 301254[60-70% Inhibition = 128 ug/ml]||Pyricularia oryzae MAFF 101511[10-20% Inhibition = 128 ug/ml]||Human hepatocellular carcinoma HepG2[80-90% Killing = 32 ug/ml]||Antibacterial||Antifungal ; Escherichia coli JCM 5491||Antimicrobial||Anticancer||Anti-Gram+||Antifungal||candidacidal||Antioxidant||anti-sepsis skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Glandirana susurra|||Glandirana susurra|||skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||skin, the Sado Wrinkled Frog, Glandirana susurra, Asia N/A skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Monkey COS-7 cells (61.7% Killing at 32 ug/ml|||Monkey COS-7 cells (61.7% Killing at 32 ug/ml "2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||Antibiotics (Basel) . 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||32751229|||32751229|||Antibiotics (Basel) . 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||Antibiotics (Basel). 2020 Jul 29;9(8):457.|||Antibiotics (Basel). 2020 Jul 29;9(8):E457. doi: 10.3390/antibiotics9080457. PubMed" 28 FPDB01528 AP03233|||AP03233|||Granuliberin-SSa|||Granuliberin-SSa|||AP03233|||DRAMP32297 " FIFLPIFRRPVS" Active against the fungus C. albicans. Granuliberin-SSa also showed activities that were almost equipotent to those of brevinin-2SSb against plant pathogens C. michiganensis subsp. michiganensis and P. oryzae. The peptide was also active against X. oryzae pv. oryzae at concentrations higher than 64 ug/ml. The peptide is toxic to mammalian cells (32 ug/ml||survival rates of COS7 and HepG2 (54.5% and 49.5%). Peptide sequence kindly provided by Prof. Iwamuro||survival rates of COS7 and HepG2 (54.5% and 49.5%). Peptide sequence kindly provided by Prof. Iwamuro.||Anti-Xanthomonas oryzae pv. oryzae MAFF 311018, activity value is MIC = 128 ug/ml||Anti-Clavibacter michiganensis subsp. michiganensis MAFF 301254, activity value is MIC = 16 ug/ml||Anti-Pyricularia oryzae MAFF 101511, activity value is MIC = 128 ug/ml||Antibacterial||Antifungal||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||candidacidal||anti-sepsis skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Glandirana susurra|||Glandirana susurra|||skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||skin, the Sado Wrinkled Frog, Glandirana susurra, Asia N/A skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Monkey COS-7 cells (45.5% Killing at 32 ug/ml|||Monkey COS-7 cells (45.5% Killing at 32 ug/ml "2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||Antibiotics (Basel) . 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||32751229|||32751229|||Antibiotics (Basel) . 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||Antibiotics (Basel). 2020 Jul 29;9(8):457.|||Antibiotics (Basel). 2020 Jul 29;9(8):E457. doi: 10.3390/antibiotics9080457. PubMed" 12 FPDB01529 AP03250|||Octominin GWLIRGAIHAGKAIHGLIHRRRH Anti-Weakly active against C. albicans, activity value is MIC = 50 ug/ml||Anti-which was essentially all killed at 100 ug/ml . Also showed significant activity against carbapenem-resistant E. coli, activity value is MIC = 4||Antifungal||candidacidal||anti-sepsis screening transcriptome database of Octopus minor|||Octopus minor|||screening transcriptome database of Octopus minor N/A N/A . 2020 Jan 15;18(1):56. doi: 10.3390/md18010056||see the 2023 Kong ref|||31952292|||Mar Drugs. 2020 Jan 15;18(1):56. doi: 10.3390/md18010056. PubMed 23 FPDB01534 AP03615|||AP03615|||Mini-ChBac7.5N alpha|||DRAMP20786|||Mini-ChBac7.5N alpha|||AP03615|||DRAMP20786 RRLRPRRPRLPRPRPRPRPRPR Anti-or M17, activity value is MIC = 1||Anti-clincla strains, activity value is MIC = 2 uM||Anti-Klebsiella spp. clinical isolate, activity value is MIC = 4 uM||Anti-A. baumannii clinical isolate, activity value is MIC = 2 uM||Anti-L. monocytogenes EGD, activity value is MIC = 2 uM||Anti-M. luteus CIP A270, activity value is MIC = 1 uM||Anti-S-aureus ATCC 25923 or 710A or MRSA, activity value is MIC > 64 uM||Anti-S-intermedius clin. isolate, activity value is MIC > 64 uM||Anti-C. albicans 820, activity value is MIC = 64 uM||Anti-and C-parapsilosis, activity value is MIC > 64 uM||Antibacterial||Antifungal||Anti-E.coli, activity value is MIC = 0.3||activity value is MIC = 1.5||activity value is MIC = 1 uM||Anti-E.coli, activity value is MIC = 0.6||activity value is MIC = 0.9||activity value is MIC = 2 uM||Anti-E.coli, activity value is MIC = 0.5||activity value is MIC = 0.8||Anti-Pseudomonas aeruginosa, activity value is MIC = 1.1||activity value is MIC = 3.7||Anti-Pseudomonas aeruginosa clinical isolate, activity value is MIC = 2 uM||Anti-Acinetobacter baumannii clinical isolate, activity value is MIC = 2 uM||Anti-Listeria monocytogenes, activity value is MIC = 0.2||activity value is MIC = 1||Anti-Micrococcus luteus CIP A270, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 0.7||activity value is MIC > 50 uM||activity value is MIC > 64 uM||Anti-Staphylococcus aureus, activity value is MIC > 64 uM||Anti-MRSA, activity value is MIC = 0.7||Anti-Staphylococcus intermedius clin. isolate, activity value is MIC > 64 uM||Anti-Candida albicans, activity value is MIC = 0.3||activity value is MIC = 64 uM||Anti-Candida parapsilosis clinical isolate, activity value is MIC > 64 uM||Anti-E.coli ML35p, activity value is MIC = 1||Anti-E.coli ATCC 25922, activity value is MIC = 2 uM||Anti-E.coli M17, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 2 uM||Anti-Acinetobacter baumannii clinical isolate, activity value is MIC = 2||Anti-Listeria monocytogenes EGD, activity value is MIC = 2 uM||Anti-Candida albicans 820, activity value is MIC = 64 uM||Anti-##Gram-positive bacteria:Listeria monocytogenes, activity value is MIC = 0.2||Anti-##Fungi:Candida albicans, activity value is MIC = 0.3||Anti-the R7A analog appeared to be slightly more active, activity value is MIC = 4 uM||Anti-the P8A analog became 8 fold less active, activity value is MIC = 64 uM neutrophils, domestic goat, Capra hircus|||neutrophils, domestic goat, Capra hircus|||Capra hircus [Goat]|||Capra hircus|||neutrophils, domestic goat, Capra hircus|||Capra hircus|||neutrophils, domestic goat, Capra hircus Rich neutrophils, domestic goat, Capra hircus||In the concentration range of 1-100 uM, there is no significant hemolytic effect on human red blood cells.|||not hemo.lytic till 100 uM. No toxicity to other mammalian cells tested till 30 uM.|||E.coli ML35p(MIC=1micoM) , E.coli ATCC 25922(MIC=2 uM), E.coli M17(MIC=2 uM), Pseudomonas aeruginosa ATCC 27853(MIC=2 uM), Pseudomonas aeruginosa clinical isolate(MIC=2 uM), Klebsiella spp. clinical isolate(MIC=4 uM), Acinetobacter baumannii clinical isolate(MIC=2microm), Listeria monocytogenes EGD(MIC=2 uM),Micrococcus luteus CIP A270(MIC=1 uM), Staphylococcus aureus 710A(MIC=>64 uM), Staphylococcus aureus ATCC 25923(MIC=>64 uM), MRSA ATCC 33591(MIC=>64 uM), Staphylococcus intermedius clin. isolate(MIC=>64 uM), Candida albicans 820(MIC=64 uM), Candida parapsilosis clinical isolate(MIC=>64 uM)|||No hemolytic activity against human erythrocytes|||In the concentration range of 1-100 uM, there is no significant hemolytic effect on human red blood cells.|||not hemo.lytic till 100 uM. No toxicity to other mammalian cells tested till 30 uM.|||[Ref.27818338] No hemolytic activity|||not hemo.lytic till 100 uM. 2016 Jul-Sep;8(3):136-146.|||Acta Naturae. 2016 Jul-Sep;8(3):136-146. Pub-Med.|||Acta Naturae. 2016 Jul-Sep;8(3):136-146. Pub-Med.|||27795854|||Acta Naturae. 2016 Jul-Sep;8(3):136-146.||Ref.27795854|||27795854|||Acta Naturae. 2016 Jul-Sep;8(3):136-146. Pub-Med.|||Acta Naturae. 2016 Jul-Sep;8(3):136-146.||Ref.27795854|||Acta Naturae. 2016 Jul-Sep;8(3):136-146. Pub-Med.||Bolosov et al., 2023 22 FPDB01556 AP00041|||Beta-defensin 6|||AP00041 QGVRNHVTCRIYGGFCVPIRCPGRTRQIGTCFGRPVKCCRRW Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-GW). Active against B. subtilis CMCC 63501, activity value is MIC = 8 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 2 uM||Anti-E. coli, activity value is MIC = 1 uM||Anti-S. enteritidis, activity value is MIC = 4 uM||Anti-and C. albicans, activity value is MIC = 16 uM cattle, Bos taurus|||Bos taurus [Bovine]|||cattle, Bos taurus Bridge N/A "J Biol Chem . 1993 Mar 25;268(9):6641-8.|||8454635|||J. Biol. Chem. 1993; 268:6641-6648.|||J. Biol. Chem. 1993; 268:6641-6648. PubMed." 42 FPDB01564 AP00050|||Bombinin-like peptides 1|||AP00050|||DRAMP01097 GIGASILSAGKSALKGLAKGLAEHFAN Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-82 % inhibition Neisseria meningitidis 118V C, activity value is MIC = 20 ug/ml||Anti-98 % inhibition Neisseria meningitidis 15240 IAI, activity value is MIC = 20 ug/ml||Anti-85% inhibition Neisseria meningitidis 126E IC1, activity value is MIC = 20 ug/ml||Anti-98% inhibition Neisseria gonorrhoeoe F62, activity value is MIC = 20 ug/ml||Anti-96% inhibition Neisseria Iactamica 15323, activity value is MIC = 20 ug/ml||Anti-100% inhibition Neisseria Iactamica 15215A, activity value is MIC = 20 ug/ml||Anti-98% inhibition Neisseria cinerea 15461, activity value is MIC = 20 ug/ml||Anti-Bacillus megaterium BmII, activity value is MIC = 0.3 uM||Anti-Staphylococcus aureus Cowan1, activity value is MIC = 3.4 uM||Anti-Escherichia coli D21, activity value is MIC = 1.7 uM||Anti-Escherichia coli D22, activity value is MIC = 1.5 uM||Anti-Yersinia pseudotubercolosis, activity value is MIC = 0.8 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 6.3 uM||Anti-Candida albicans, activity value is MIC = 0.4 uM||active against N. meningitidis strains 118V||15240||126E||N. gonorrhoeae||N. lactamica||and N. cinerea (82-100% killing at 20 ug/ml)||but did not kill E-coli||K-acyloca||P-aeruginosa||K-pmeumoniae||E-cloacae under the same conditions. Also active against B. megaterium BmII||S. aureus Cowan1||E. coli D21||E. coli D22||Y. pseudotubercolosis||P. aeruginosa ATCC 15692||and C. albicans .||Antimicrobial||Anti-82% inhibition Neisseria meningitidis 118V C, activity value is MIC = 20 ug/ml||Anti-98% inhibition Neisseria meningitidis 15240 IAI, activity value is MIC = 20 ug/ml Oriental fire-bellied toad/frog, Bombina orientalis, Asia|||Bombina orientalis [Oriental fire-bellied toad]|||Oriental fire-bellied toad/frog, Bombina orientalis, Asia|||Bombina orientalis (Oriental fire-bellied toad) Helix||Alpha helix [Ref.1744108] No significant hemolytic activity against human red blood cell. "J Biol Chem . 1991 Dec 5;266(34):23103-11.|||1744108|||J. Biol. Chem. 1991; 266: 23103-23111.||Simmaco et al. 1998|||J Biol Chem. 1991 Dec 5;266(34):23103-23111.|||J Biol Chem. 1991 Dec 5;266(34):23103-23111.||Ref.1744108|||J. Biol. Chem. 1991; 266: 23103-23111. PubMed." 27 FPDB01566 AP00052|||Bombinin-like peptides 3|||AP00052|||DRAMP01098 GIGAAILSAGKSALKGLAKGLAEHF Active against N. meningitidis strains 118V||15240||126E||N. gonorrhoeae||N. lactamica||and N. cinerea (59-100% at 20 ug/ml)||but did not kill E.coli||K.acyloca||P.aeruginosa||K.pmeumoniae||E.cloacae under the same conditions. Also active against B. megaterium BmII||S. aureus Cowan1||E. coli D21||E. coli D22||Y. pseudotubercolosis||P. aeruginosa ATCC 15692||and C. albicans .||Antibacterial||Anti-postive bacterium:Bacillus megaterium BmII, activity value is MIC = 0.3 uM||Anti-Staphylococcus aureus Cowan1, activity value is MIC = 1.7 uM||Anti-59% inhibition Neisseria meningitidis 118V C, activity value is MIC = 20 ug/ml||Anti-99% inhibition Neisseria meningitidis 15240 IAI, activity value is MIC = 20 ug/ml||Anti-99% inhibition Neisseria meningitidis 126E IC1, activity value is MIC = 20 ug/ml||Anti-99% inhibition Neisseria gonorrhoeoe F62, activity value is MIC = 20 ug/ml||Anti-97% inhibitionNeisseria Iactamica 15323, activity value is MIC = 20 ug/ml||Anti-100% inhibition Neisseria Iactamica 15215A, activity value is MIC = 20 ug/ml||Anti-97% inhibition Neisseria cinerea 15461, activity value is MIC = 20 ug/ml||Anti-Escherichia coli D21, activity value is MIC = 1.7 uM||Anti-Escherichia coli D22, activity value is MIC = 1.5 uM||Anti-Yersinia pseudotubercolosis, activity value is MIC = 0.6 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 9.2 uM||Anti-Fungus:Candida albicans, activity value is MIC = 0.4 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal Oriental fire-bellied toad/frog, Bombina orientalis, Asia|||Bombina orientalis [Oriental fire-bellied toad]|||Oriental fire-bellied toad/frog, Bombina orientalis, Asia|||Bombina orientalis (Oriental fire-bellied toad) Helix||Alpha helix 59 % inhibition Neisseria meningitidis 118V C ( MIC = 20 ug/ml), 99 % inhibition Neisseria meningitidis 15240 IAI ( MIC = 20 ug/ml), 99% inhibition Neisseria meningitidis 126E IC1 ( MIC = 20 ug/ml), 99% inhibition Neisseria gonorrhoeoe F62 ( MIC = 20 ug/ml), 97% inhibitionNeisseria Iactamica 15323 ( MIC = 20 ug/ml), 100% inhibition Neisseria Iactamica 15215A ( MIC = 20 ug/ml), 97% inhibition Neisseria cinerea 15461 ( MIC = 20 ug/ml), Bacillus megaterium BmII ( MIC = 0.3 uM, Staphylococcus aureus Cowan1 ( MIC = 1.7 uM, Escherichia coli D21 ( MIC = 1.7 uM, Escherichia coli D22 ( MIC = 1.5 uM, Yersinia pseudotubercolosis ( MIC = 0.6 uM, Pseudomonas aeruginosa ATCC 15692 ( MIC = 9.2 uM, Candida albicans ( MIC = 0.4 uM )|||[Ref:1744108] No significant hemolytic activity was found which suggests a selectivity for prokaryotic over eukaryotic membranes. "J Biol Chem . 1991 Dec 5;266(34):23103-11.||Simmaco et al. 1998|||1744108|||J. Biol. Chem. 1991; 266: 23103-23111.||Simmaco et al. 1998|||Ref.1744108|||J. Biol. Chem. 1991; 266: 23103-23111. PubMed." 25 FPDB01569 AP00059|||Maximin 2|||DRAMP01108|||Maximin 2|||AP00059|||AP00059 GIGTKILGGVKTALKGALKELASTYVN Anti-E. coli ATCC25922, activity value is MIC = 19.5 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 19.5 ug/ml||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 19.5 ug/ml||Anti-B. megatherium, activity value is MIC = 19.5 ug/ml||Anti-B. dysenterium, activity value is MIC = 2.7 ug/ml||Anti-K. pneumoniae, activity value is MIC = 9 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 3 uM||Anti-Escherichia coli ATCC25922, activity value is MIC = 19.5 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 19.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB10104, activity value is MIC = 19.5 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 19.5 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 2.7 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 9 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 3 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 19.5 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 19.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 19.5 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia N/A In Document 3 (Eur. J. Immunol. 2005), the specific hemolytic values of the maximin family and maximin H family antimicrobial peptides in the skin secretions of the large-webbed bell toad (Bombina maxima) are not explicitly mentioned.|||No hemolytic activity (0% hemolysis at 100 µM) "Peptides . 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides 2002; 23:427-435. PubMed." 27 FPDB01572 AP00073|||Brevinin-1E|||DRAMP02081|||AP00073|||DRAMP02081|||AP00073 FLPLLAGLAANFLPKIFCKITRKC inhibition zone assay (lethal concentration LC: minimal concnetration for inhibition||MIC-like): Active against E. coli D21 (LC 1.8 uM)||B. megaterium BmII||S. aureus Cowan 1 (LC 0.4-0.6 uM)||P. aeruginosa ATCC15692 (LC 30.6 uM)||C. albicans||and S. cerevisiae (LC 3.8-4.7 uM). In addition||this peptide promotes insulin secretion in acute 20-min incubations with glucose responsive BRIN-BD11 cells||thereby of interest for type 2 diabetes (T2D).||Antibacterial||Anti-Escherichia coliD21, activity value is MIC = 1.8 uM||Anti-Pseudomonas aeruginosa ATCC15692, activity value is MIC = 30.6 uM||Anti-Bacillus megaterium Bm11, activity value is MIC = 0.4 uM||Anti-Staphylococcus aureus Cowan1, activity value is MIC = 0.6 uM||Anti-Candida albicans, activity value is MIC = 4.7 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 3.8 uM||Anti-##Gram-positive bacteria: Bacillus megaterium Bm11, activity value is MIC = 0.4 uM||Anti-##Fungi: Candida albicans, activity value is MIC = 4.7 uM||Anti-##Yeast: Saccharomyces cerevisiae, activity value is MIC = 3.8 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-diabetes||Hemolytic Edible frog, Rana esculenta , Europe; also found in skin secretions, Rana ridibunda, Asia (see AP1899 ref)|||Rana esculenta (edible frog ) [Edible frog]|||Rana ridibunda [Marsh frog]|||Rana esculenta (Edible frog) (Pelophylax esculentus)|||Edible frog, Rana esculenta , Europe; also found in skin secretions, Rana ridibunda, Asia (see AP1899 ref)|||Rana esculenta (Edible frog) (Pelophylax esculentus)|||Edible frog, Rana esculenta , Europe; also found in skin secretions, Rana ridibunda, Asia (see AP1899 ref) Alpha helix "Hemolytic activity test results: Maximin-type peptides exhibit almost no hemolytic activity against red blood cells at concentrations up to 50 µg/ml, whereas Maximin H-type peptides can cause 90-100% hemolysis of rabbit red blood cells at a concentration of 50 µg/ml. Example data: Maximin H1-H4: 90-100% hemolysis at 50 µg/ml. Maximin 1-5: almost no hemolytic activity at 50 µg/ml.|||Red blood cells (0.5 uM)|||shows hemolytic activity|||brevinin-1E: The hemolytic activity was strong, the concentration of hemolysis was 0.5 uM; • brevinin-2E: very low hemolysis, hemolysis concentration> 100 uM; • esculentin: very low hemolysis, hemolysis concentration> 100 uM.|||[Ref.8163497] LC50=0.5 uM against human red blood cell.|||It is highly hemolytic at 0.5 uM." "Comparative Study J Biol Chem . 1994 Apr 22;269(16):11956-61.||Marenah L et al., 2006|||8508915|||J Biol Chem. 1994 Apr 22;269(16):11956-11961.||Ref.8163497|||J Biol Chem. 1994 Apr 22;269(16):11956-61.||Marenah L et al., 2006|||Ref.8163497|||FEBS Lett. 1993 Jun 14;324(2):159-161.##J Biol Chem. 1994 Apr 22;269(16):11956-11961.||Ref.8163497|||J Biol Chem. 1994 Apr 22;269(16):11956-61. PubMed." 24 FPDB01575 AP00080|||DRAMP01513|||AP00080|||DRAMP01513 GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC Zone inhibition assays: Active against E. coli D 21(lethal concentration LC 0.2 uM)||B. megaterium BmII (LC 0.1 uM)||S. aureus Cowan 1(LC 0.4 uM)||P. aeruginosa ATCC15692 (LC 0.7 uM)||C. albicans (LC 0.5 uM) and S. cerevisiae (LC 0.9 uM). (MIC data provided by Chunfeng Wang).||Anti-Escherichia coli D21, activity value is MIC = 0.2 uM||Anti-Pseudomonas aeruginosaATCC15692, activity value is MIC = 0.7 uM||Anti-Bacillus megaterium Bm11, activity value is MIC = 0.1 uM||Anti-Staphylococcus aureus Cowan1, activity value is MIC = 0.4 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 0.9 uM||C. albicans (LC 0.5 uM) and S. cerevisiae (LC 0.9 uM). (LC=lethal concentration||data provided by Chunfeng Wang).||Anti-Gram+ & Gram-||Antifungal||candidacidal||Insecticidal||anti-diabetes||Hemolytic Edible frog, Rana esculenta, Europe|||Rana esculenta (Edible frog) (Pelophylax esculentus)|||Edible frog, Rana esculenta, Europe|||Rana esculenta (Edible frog) (Pelophylax esculentus) Helix "Hemolytic activity test results: Brevinin-1E: The hemolytic concentration is 0.5 µM, and its activity is stronger than that of melittin (hemolytic concentration 0.9 µM). brevinin-2E: Hemolytic concentration >100 µM, exhibiting almost no hemolytic activity. esculentin: Hemolytic concentration> 100 µM, exhibiting almost no hemolytic activity. bombinin: hemolytic concentration> 50 µM. Cecropin A: hemolytic concentration> 400 µM. Melittin: hemolytic concentration 0.9 µM.|||In the study of the novel antimicrobial peptide odorranain-NR from the skin of the toad Lithobates without webbed teeth, odorranain-NR exhibited extremely low hemolytic activity against rabbit red blood cells, and no obvious hemolysis was observed even at concentrations as high as 100 µg/ml.|||[Ref. 8163497] LC>100 uM|||[Ref. 8163497] LC>100 uM|||human RBC: > 100 uM (pep conc?)." "Comparative Study FEBS Lett . 1993 Jun 14;324(2):159-61. doi: 10.1016/0014-5793(93)81384-c.|||FEBS Lett. 1993 Jun 14;324(2):159-161.|||8508915|||FEBS Lett. 1993; 324:159-161. doi: 10.1016/0014-5793(93)81384-c.|||Gram-negative bacteria: Escherichia coli D21 (MIC=0.2 uM), Pseudomonas aeruginosaATCC15692 (MIC=0.7 uM); Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.1 uM), Staphylococcus aureus Cowan1 (MIC=0.4 uM). Fungi: Candida albicans (MIC=0.5 uM), Saccharomyces cerevisiae (MIC=0.9 uM).|||FEBS Lett. 1993; 324:159-161. PubMed." 46 FPDB01576 AP00081|||DRAMP18196|||DRAMP01489 GIFSKLAGKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC Anti-Gram- bacteria E. coli D21, activity value is MIC = 0.2 uM||Anti-P. aeruginosa ATCC 15692, activity value is MIC = 0.7 uM||Anti-Y. pseudotuberculosis YPIII, activity value is MIC = 0.1 uM||Anti-P. syringae pv tabaci, activity value is MIC = 0.2 uM||Anti-E. agglomerans Bo-1S, activity value is MIC = 0.4 uM||Anti-B. megaterium Bm11, activity value is MIC = 0.1 uM||Anti-S. aureus Cowan I, activity value is MIC = 0.4 uM||Anti-and fungi C. albicans clinical isolate, activity value is MIC = 0.5 uM||Anti-V. alginolyticus ATCC17749, activity value is MIC = 25 ug/ml||Anti-V. anguillarum ATCC19264, activity value is MIC = 6.25 ug/ml||Anti-C. freundii ATCC43864, activity value is MIC = 12.5 ug/ml||Anti-S. fexneri, activity value is MIC = 50 ug/ml||Anti-S. saprophyticus, activity value is MIC = 6.25 ug/ml||Anti-and L. monocytogenes ATCC19115, activity value is MIC = 50 ug/ml||Antimicrobial||Antibacterial||Antibiotic||Anti-Gram+||Anti-Gram-||Anti-Gram+ & Gram-||Antifungal||candidacidal Edible frog, Pelophylax lessonae/ridibundus, old nameRana esculenta , also found in a dark-spotted frog, Pelophylax nigromaculatus, Europe|||Viola hederacea (Australian violet)|||Rana esculenta (European Edible frog) N/A "Hemolytic activity test results: Maximin-type peptides show almost no hemolytic activity against red blood cells at concentrations up to 50 µg/ml, whereas maximin H-type peptides can cause 90-100% hemolysis of rabbit red blood cells at 50 µg/ml concentration. Example data: Maximin H1-H4: 90-100% hemolysis at 50 µg/ml. Maximin 1-5: Almost no hemolytic activity at 50 µg/ml.|||human RBC, lethal concentration >200 uM: not hemo.lytic (Ponti et al., 1999." "Comparative Study J Biol Chem . 1994 Apr 22;269(16):11956-61.||see the 2024 ref above|||J Biol Chem. 1994 Apr 22;269(16):11956-61.||see the 2024 ref above|||J Mol Biol. 1999 Dec 17;294(5):1327-1336.|||J Biol Chem. 1994 Apr 22;269(16):11956-11961.|||J Biol Chem. 1994 Apr 22;269(16):11956-61. PubMed." 46 FPDB01583 AP00089|||Gaegurin-5|||DRAMP02295|||Gaegurin-5|||AP00089|||AP00089 FLGALFKVASKVLPSVFCAITKKC Anti-M. luteus, activity value is MIC = 2.5 ug/ml||Anti-S. epidermidis, activity value is MIC = 10 ug/ml||Anti-B. subtilis, activity value is MIC = 10 ug/ml||Anti-K. pneumoniae, activity value is MIC = 50 ug/ml||Anti-S. dysentariae, activity value is MIC = 50 ug/ml||Anti-P. putida, activity value is MIC = 50 ug/ml||Anti-P. aeruginosa, activity value is MIC = 100 ug/ml||Anti-E. coli, activity value is MIC = 75 ug/ml||Anti-S. cerevisiae, activity value is MIC = 50 ug/ml||Anti-C. albicans, activity value is MIC = 50 ug/ml||Antibacterial||Antifungal||Antiparasitic||Anti-Micrococcus luteus, activity value is MIC = 2.5 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 10 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 10 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 50 ug/ml||Anti-Shigella dysentariae, activity value is MIC = 50 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 100 ug/ml||Anti-Eshchericia coli, activity value is MIC = 50 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC = 50 ug/ml||Anti-Candida albicans, activity value is MIC = 50 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 200 ug/ml||Anti-Proteus mirabilis, activity value is MIC > 200 ug/ml||Anti-Gram+ & Gram-||candidacidal skin, Korean wrinkled frog Rana rugosa, Asia|||Rana rugosa [Japanese wrinkled frog]|||Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)|||Rana rugosa [Japanese wrinkled frog]|||skin, Korean wrinkled frog, Glandirana emeljanovi, previously Rana rugosa, Asia|||skin, Korean wrinkled frog Rana rugosa, Asia N/A "Hemolytic activity test results: At a concentration of 100 μg/ml, the hemolysis rates of gaegurin 1-6 on human red blood cells were all below 2%, while the positive control melittin showed a hemolysis rate of 37.67% at 10 μg/ml and reached 98.92% at 100 μg/ml. Sample data: gaegurin 1: Hemolysis rate 0.59% at 100 μg/ml. gaegurin 2: Hemolysis rate 0.82% at 100 μg/ml. gaegurin 3: Hemolysis rate 1.20% at 100 μg/ml. gaegurin 4: Hemolysis rate 1.67% at 100 μg/ml. gaegurin 5: Hemolysis rate 1.01% at 100 μg/ml. gaegurin 6: Hemolysis rate 0.86% at 100 μg/ml.|||Micrococcus luteus ( MIC = 2.5 ug/ml), Staphylococcus epidermidis ( MIC = 10 ug/ml), Bacillus subtilis ( MIC = 10 ug/ml), Klebsiella pneumoniae ( MIC = 50 ug/ml), Shigella dysentariae ( MIC = 50 ug/ml), Pseudomonas putida ( MIC = 50 ug/ml), Pseudomonas aeruginosa ( MIC = 100 ug/ml), Eshchericia coli ( MIC = 50 ug/ml), Saccharomyces cerevisiae ( MIC = 50 ug/ml), Candida albicans ( MIC = 50 ug/ml), Salmonella typhimurium ( MIC = 200 ug/ml), Proteus mirabilis ( MIC = >200 ug/ml), Serratia marcescens ( MIC = >200 ug/ml)|||In Document 8 (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1994), six gaegurin family antimicrobial peptides (gaegurin 1-6) were isolated from the skin of the wrinkled frog (Rana rugosa), and their hemolytic activity was extremely low; at a concentration of 100 µg/ml, the hemolysis rates were 0.59% for gaegurin 1, 0.82% for gaegurin 2, 1.20% for gaegurin 3, 1.67% for gaegurin 4, 1.01% for gaegurin 5, and 0.86% for gaegurin 6; as a control, the bee venom hemolytic peptide had a hemolysis rate of 98.92% at 100 µg/ml." "Biochem Biophys Res Commun . 1994 Nov 30;205(1):948-54. doi: 10.1006/bbrc.1994.2757.|||7999137|||Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.||Ref.7999137|||7999137|||Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-54.doi: 10.1006/bbrc.1994.2757.|||Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-54.PubMed." 24 FPDB01587 AP00095|||Temporin-B|||AP00095|||Temporin-B|||AP00095 LLPIVGNLLKSLL Anti-S. pyogenes beta hem. group A, activity value is MIC = 2.8||Anti-P.aeruginosa ATCC15692, activity value is MIC > 360 uM||Anti-and C. albicans, activity value is MIC = 4 uM||Anti-including parasites L. donovani promastigotes and L. mexicana, activity value is MIC = 24||Anti-and A. baumannii, activity value is MIC = 24 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram-||Antiviral||candidacidal||Antiparasitic||Chemotactic||Antibiofilm||Anti-S. aureus, activity value is MIC = 12 European common frog, Rana temporaria|||Rana temporaria [european common frog]|||European common frog, Rana temporaria|||Rana temporaria [european common frog]|||European common frog, Rana temporaria Helix "Hemolytic activity test results: Temporin A and Temporin B both showed less than 1% hemolysis of human red blood cells at a concentration of 120 μM, whereas bee venom peptide (melittin) can cause more than 90% red blood cell hemolysis at 0.9 μM. Example data: Temporin A: Hemolytic concentration > 120 μM. Temporin B: Hemolytic concentration > 120 μM. Melittin: Hemolytic concentration 0.9 μM.|||The document clearly mentions the hemolytic values of four main peptides (temporin A, temporin B, esculentin 1, cecropin A) and two control peptides (MLP, melittin), specifically their hemolytic activity against human red blood cells (expressed as ""lethal concentration, LC"", which is the minimum concentration that induces hemolysis), as follows: temporin A: >120 µM (no hemolytic activity observed even at concentrations exceeding 120 µM) temporin B: >120 µM (no hemolytic activity observed even at concentrations exceeding 120 µM) esculentin 1: >200 µM (no hemolytic activity observed even at concentrations exceeding 200 µM) cecropin A: >400 µM (no hemolytic activity observed even at concentrations exceeding 400 µM) Control peptide MLP (melittin-like peptide): 0.5 µM (induces hemolysis at extremely low concentrations) Control peptide melittin (bee venom peptide): 0.9 µM (induces hemolysis at extremely low concentrations) The above values were determined by the following experiment: peptides at different concentrations were co-incubated with human red blood cells, and hemolysis was observed. The ""lethal concentration"" (minimum hemolytic concentration) was calculated using the inhibition zone assay, which is the lowest peptide concentration that can induce red blood cell hemolysis; the higher the value, the weaker the peptide's hemolytic activity. Furthermore, the study indicates that the temporin family (such as temporin A and B), although structurally similar to the hemolytic peptides in wasp venom, has no inherent hemolytic activity, whereas the control peptides (MLP and melittin) strongly induce hemolysis at very low concentrations, highlighting the low toxicity advantage of temporins toward eukaryotic cells.|||The hemolytic concentration of temporin A on human red blood cells is >120 µM. The hemolytic concentration of temporin B on human red blood cells is >120 µM. The hemolytic concentration of melittin on human red blood cells is 0.9 µM. The hemolytic concentration of melittin-like peptide (MLP) on human red blood cells is 0.5 µM. The hemolytic concentration of defensin 1 (esculentin 1) on human red blood cells is >200 µM. The hemolytic concentration of cecropin A on human red blood cells is >400." "Eur J Biochem . 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||Maisetta et al., 2016||Marcocci ME et al., 2018||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90|||9022710|||Eur J Biochem. 1996 Dec 15;242(3):788-92. PubMed.|||9022710|||Eur J Biochem. 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||Maisetta et al., 2016||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90|||1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||Maisetta et al., 2016||Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90" 13 FPDB01592 AP00104|||Temporin-1Ca|||AP00104|||DRAMP01819 FLPFLAKILTGVL Anti-S. aureus, activity value is MIC = 17 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-and C. albicans, activity value is MIC = 14 uM||Antibacterial||No MICs found in DRAMP database||Anti-Gram+||Antifungal||candidacidal skin, the European common frog, Rana temporaria, Europe|||Rana clamitans (green frog) [Green frog]|||skin, the European common frog, Rana temporaria, Europe|||Rana clamitans (Green frog) (Lithobates clamitans) N/A N/A "Peptides . 2000 Apr;21(4):469-76. doi: 10.1016/s0196-9781(00)00178-9.|||10822101|||Peptides. 2000 Apr;21(4):469-76. doi: 10.1016/s0196-9781(00)00178-9.|||Peptides. 2000 Apr;21(4):469-76. PubMed." 13 FPDB01601 AP00114|||Ranatuerin-1|||DRAMP02228|||Ranatuerin-1|||AP00114|||AP00114 SMLSVLKNLGKVGLGFVACKINKQC Anti-E. coli, activity value is MIC = 2 uM||Anti-S. aureus, activity value is MIC = 50 uM||Anti-and C. albicans, activity value is MIC = 70 uM||Antibacterial||Antifungal||Anti-Staphylococcus aureus, activity value is MIC = 50 uM||Anti-Escherichia coli, activity value is MIC = 2 uM||Anti-Candida albicans, activity value is MIC = 70 uM||Anti-S.aureus, activity value is MIC = 50 uM||Anti-E.coli, activity value is MIC = 2 uM||Anti-C.albicans, activity value is MIC = 70 uM||Anti-Gram+ & Gram-||candidacidal North American bull frog, Rana catesbeiana|||Rana catesbeiana [American bullfrog]|||Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)|||Rana catesbeiana [American bullfrog]|||North American bull frog, Rana catesbeiana|||North American bull frog, Rana catesbeiana Alpha helix Hemolytic activity on human erythrocytes: At a concentration of 20 μg/ml, Ranatuerins 1-9 show no significant hemolytic activity on human erythrocytes.|||S.aureus ( MIC = 50 uM), E.coli ( MIC = 2 uM), C.albicans ( MIC = 70 uM)|||Frog skin antimicrobial peptides ranatuerins 1-9, at a concentration of 20 μg/ml, did not show detectable hemolysis on human red blood cells. "Biochem Biophys Res Commun . 1998 Sep 29;250(3):589-92. doi: 10.1006/bbrc.1998.9362.|||9784389|||Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592.||Ref.9784389|||9784389|||Biochem. Biophys. Res. Commun. 1998; 250: 589-592.doi: 10.1006/bbrc.1998.9362.|||Biochem. Biophys. Res. Commun. 1998; 250: 589-592.PubMed." 25 FPDB01606 AP00119|||DRAMP02255|||Ranatuerin-2Lb|||AP00119|||DRAMP02255 GILSSIKGVAKGVAKNVAAQLLDTLKCKITGC Anti-strongly active against S. aureus, activity value is MIC = 4 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-and weakly C. albicans, activity value is MIC = 62 uM||Anti-Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Escherichia coli, activity value is MIC = 4 uM||Anti-Candida albicans, activity value is MIC = 62 uM||Antibacterial||Antifungal||Anti-##Gram-negative bacterium: Escherichia coli, activity value is MIC = 4 uM||Anti-##Yeast: Candida albicans, activity value is MIC = 62 uM||Anti-Gram+ & Gram-||candidacidal North American frog, Rana luteiventris, ALSO: the Oregon spotted frog Rana pretiosa|||Rana luteiventris (Spotted frog) (Rana pretiosa)|||Rana luteiventris [Spotted frog]|||North American frog, Rana luteiventris, ALSO: the Oregon spotted frog Rana pretiosa|||Rana luteiventris (Spotted frog) (Rana pretiosa) N/A No hemolysis information or data found in the reference(s) presented in this entry "Comparative Study Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Ref.10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed." 32 FPDB01607 AP00120|||Ranatuerin-2B|||DRAMP02256|||Ranatuerin-2B|||AP00120|||DRAMP02256|||AP00120 GLLDTIKGVAKTVAASMLDKLKCKISGC Anti-S. aureus, activity value is MIC = 2 uM||Anti-E. coli, activity value is MIC = 2 uM||Anti-and C. albicans, activity value is MIC = 35 uM||S. aureus||E. coli||C. albicans||Anti-Staphylococcus aureus, activity value is MIC = 2 uM||Anti-Escherichia coli, activity value is MIC = 2 uM||Anti-Candida albicans, activity value is MIC = 35 uM||Antibacterial||Antifungal||Anti-##Gram-negative bacterium: Escherichia coli, activity value is MIC = 2 uM||Anti-##Yeast: Candida albicans, activity value is MIC = 35 uM||Anti-Gram+ & Gram-||candidacidal North American frog, Rana berlandieri|||Rana berlandieri [Rio Grande leopard frog]|||Rana berlandieri (Rio Grande leopard frog) (Rana luteiventris)|||Rana berlandieri [Rio Grande leopard frog]|||North American frog, Rana berlandieri|||Rana berlandieri (Rio Grande leopard frog) (Rana luteiventris)|||North American frog, Rana berlandieri N/A No hemolysis information or data found in the reference(s) presented in this entry "Comparative Study Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Ref.10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed." 28 FPDB01608 AP00122|||Ranatuerin-1C|||DRAMP02246|||Ranatuerin-1C|||AP00122|||DRAMP02246|||AP00122 SMLSVLKNLGKVGLGLVACKINKQC Anti-S. aureus, activity value is MIC = 55 uM||Anti-E. coli, activity value is MIC = 1.5 uM||Anti-and C. albicans, activity value is MIC = 58 uM||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 9.375 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC > 100 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 18.75 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 55 uM||Anti-Escherichia coli, activity value is MIC = 1.5 uM||Anti-S.aureus, activity value is MIC = 55 uM||Anti-E.coli, activity value is MIC = 1.5 uM||Anti-C.albicans, activity value is MIC = 58 uM||Anti-Gram+ & Gram-||candidacidal North American green frog Rana clamitans|||Rana clamitans [Green frog]|||Rana clamitans (Green frog) (Lithobates clamitans)|||Rana clamitans [Green frog]|||North American green frog Rana clamitans|||Rana clamitans (Green frog) (Lithobates clamitans)|||North American green frog Rana clamitans N/A S.aureus ( MIC = 55 uM), E.coli ( MIC = 1.5 uM), C.albicans ( MIC = 58 uM)|||MiAMP1, at a concentration of 100 µg/ml, has no hemolytic effect on human red blood cells, and no red blood cell lysis was observed. "Comparative Study Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||10822101|||Peptides. 2000 Apr;21(4):469-476.||Ref.18282640|||10822101||Ref.10822101|||10822101|||Eur J Biochem. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Ref.10822101|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed." 25 FPDB01609 AP00123|||Ranatuerin-2Cb|||DRAMP02245|||Ranatuerin-2Cb|||AP00123|||DRAMP02245|||AP00123 GLFLDTLKGLAGKLLQGLKCIKAGCKP Anti-S. aureus, activity value is MIC = 40 uM||Anti-E. coli, activity value is MIC = 2 uM||Anti-and C. albicans, activity value is MIC = 46 uM||Anti-S.aureus, activity value is MIC = 40 uM||Anti-E.coli, activity value is MIC = 2 uM||Anti-C.albicans, activity value is MIC = 46 uM||Anti-Staphylococcus aureus, activity value is MIC = 40 ug/ml||Anti-Escherichia coli, activity value is MIC = 2 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Gram+ & Gram-||candidacidal North American green frog Rana clamitans|||Rana clamitans [Green frog]|||Rana clamitans (Green frog) (Lithobates clamitans)|||Rana clamitans [Green frog]|||North American green frog Rana clamitans|||Rana clamitans (Green frog) (Lithobates clamitans)|||North American green frog Rana clamitans N/A N/A "Comparative Study Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||10822101|||Peptides. 2000 Apr;21(4):469-476.||Ref.10822101|||10822101|||Eur J Biochem. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Peptides. 2000 Apr;21(4):469-476.|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed." 27 FPDB01628 AP00151 GFCRCVCRRGVCRCVCTR Anti-and C. albicans 16820. Active against drug resistant C. albicans clinical isolates, activity value is MIC = 6.2||Anti-Gram+ & Gram-||Antifungal||candidacidal Olive baboon, Papio anubis, and blood leukocytes, Hamadryas baboon, Papio hamadryas N/A N/A Basso et al., 2018|||Infect Immun. 2008 Dec;76(12):5883-91.||Basso et al., 2018|||Infect Immun. 2008 Dec;76(12):5883-91. 18 FPDB01631 AP00156 GVCRCVCRRGVCRCVCRR Anti-and C. albicans 16820. Active against drug resistant C. albicans clinical isolates, activity value is MIC = 1.56||Anti-Gram+ & Gram-||Antifungal||candidacidal Papio anubis Beta N/A "Infect Immun . 2008 Dec;76(12):5883-91. doi: 10.1128/IAI.01100-08. Epub 2008 Oct 13.||Basso et al., 2018|||Infect Immun. 2008 Dec;76(12):5883-91. doi: 10.1128/IAI.01100-08. Epub 2008 Oct 13.||Basso et al., 2018|||Infect Immun. 2008 Dec;76(12):5883-91. PubMed." 18 FPDB01632 AP00158|||DRAMP01669|||Dermaseptin-2|||AP00158|||DRAMP01669 ALWFTMLKKLGTMALHAGKAALGAAANTISQGTQ Anti-A. caviae IP67-16T, activity value is MIC = 1 uM||Anti-E. coli IP76-24, activity value is MIC = 2.5 uM||Anti-S. aureus IP76-25, activity value is MIC = 10||Anti-N. brasiliensis IP118079, activity value is MIC = 20 uM||Anti-S. cerevisiae IP118079, activity value is MIC = 5 uM||Anti-IP886-65, activity value is MIC = 5||Anti-C. neoformans IP960-67 and IP962-67, activity value is MIC = 1 uM||Anti-M. canis IP1194, activity value is MIC = 15 uM||Anti-T. rubrum IP2043-92, activity value is MIC = 35 uM||Anti-T. metagrophytes IP877-71, activity value is MIC = 20 uM||Anti-mutant, activity value is MIC = 20||Anti-A. simii J43, activity value is MIC = 20 uM||Anti-A. niger IP218-53 and A. fumigatus IP1025-70, activity value is MIC = 20 uM||Anti-C. albicans, activity value is MIC = 15 ug/ml||Anti-N. brasiliensis, activity value is MIC = 30 ug/ml||Antimicrobial||Antibacterial||Antifungal||Antiprotozoal||Anti-Active against A. caviae IP67-16T, activity value is MIC = 1 uM||Anti-Gram+ & Gram-||Antiviral||candidacidal||Antiparasitic Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Phyllomedusa sauvagii [Sauvage frog]|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog) Alpha helix "Dermaseptin S3: At 80 μM, it can cause hemolysis of red blood cells within 1 hour. Dermaseptin S4: At 1 μM, it causes 100% hemolysis within 1 hour; at 0.5 μM, 50% hemolysis occurs. Dermaseptin S5: At a concentration of 90 μM, treatment for 1 hour does not cause hemolysis of human red blood cells.|||No hemolytic activity (0% hemolysis at 200 μM)" "J Biol Chem . 1994 Dec 16;269(50):31635-41.|||Eur J Biochem. 1994 Jan 15;219(1-2):145-154.|||8306981|||J Biol Chem. 1994;269(50):31635-31641.|||Eur J Biochem. 1994 Jan 15;219(1-2):145-154.|||1994 Dec 16;269(50):31635-41.|||J Biol Chem. 1994;269(50):31635-31641.PubMed." 34 FPDB01633 AP00159|||DRAMP01670|||Dermaseptin-3|||AP00159|||DRAMP01670|||AP00159|||Dermaseptin-3 ALWKNMLKGIGKLAGKAALGAVKKLVGAES Anti-A. caviae IP67-16T, activity value is MIC = 1 uM||Anti-E. coli IP76-24, activity value is MIC = 2.5 uM||Anti-S. aureus IP76-25, activity value is MIC = 10 uM||Anti-N. brasiliensis IP118079, activity value is MIC = 5 uM||Anti-S. cerevisiae IP118079, activity value is MIC = 5 uM||Anti-IP886-65, activity value is MIC = 10 uM||Anti-C. neoformans IP960-67 and IP962-67, activity value is MIC = 1 uM||Anti-M. canis IP1194, activity value is MIC = 15 uM||Anti-T. rubrum IP2043-92, activity value is MIC = 40 uM||Anti-T. metagrophytes IP877-71, activity value is MIC = 20 uM||Anti-mutant, activity value is MIC = 20||Anti-A. simii J43, activity value is MIC = 10 uM||Anti-A. niger IP218-53 and A. fumigatus IP1025-70, activity value is MIC = 10||Antimicrobial||Antibacterial||Antifungal||Antiprotozoal||Antiviral||Anti-Malarial parasite strain H, activity value is IC50 = 0.8 uM||Anti-Malarial parasite strain NF54, activity value is IC50 = 0.26 uM||Anti-Gram+ & Gram-||candidacidal||Antiparasitic||Antimalarial Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Phyllomedusa sauvagii [Sauvage frog]|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagii Alpha helix No hemolytic activity (0% hemolysis at 200 μM) "J Biol Chem . 1994 Dec 16;269(50):31635-41.||Ghosh et al., 1998|||Eur J Biochem. 1994 Jan 15;219(1-2):145-155.|||9395500|||J Biol Chem. 1994;269(50):31635-31641.||Ghosh et al., 1998|||Eur J Biochem. 1994 Jan 15;219(1-2):145-155.J Biol Chem. 1997 Dec 12;272(50):31609-31616.|||1994 Dec 16;269(50):31635-41.||Ghosh et al., 1998|||https://pubmed.ncbi.nlm.nih.gov/9395500|||J Biol Chem. 1994;269(50):31635-31641.PubMed." 30 FPDB01634 AP00161|||DRAMP01672|||Dermaseptin-5|||AP00161|||DRAMP01672 " GLWSKIKTAGKSVAKAAAKAAVKAVTNAV" Anti-A. caviae IP67-16T, activity value is MIC = 35 uM||Anti-E. coli IP76-24, activity value is MIC = 35 uM||Anti-E. faecalis IP103214, activity value is MIC = 40 uM||Anti-S. aureus IP76-25, activity value is MIC = 2 uM||Anti-N. brasiliensis IP118079, activity value is MIC = 40 uM||Anti-S. cerevisiae IP118079, activity value is MIC = 5 uM||Anti-IP886-65, activity value is MIC = 10 uM||Anti-C. neoformans IP960-67 and IP962-67, activity value is MIC = 1 uM||Anti-M. canis IP1194, activity value is MIC = 15 uM||Anti-T. rubrum IP2043-92, activity value is MIC = 20 uM||Anti-T. metagrophytes IP877-71, activity value is MIC = 20 uM||Anti-mutant, activity value is MIC = 30 uM||Anti-A. simii J43, activity value is MIC = 20 uM||Anti-A. niger IP218-53, activity value is MIC = 30 uM||Antimicrobial||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Antiparasitic Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Phyllomedusa sauvagii [Sauvage frog]|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America N/A "At a concentration of 70 µM, treatment for 1 hour did not cause hemolysis of human red blood cells. At 70 µM, hemolysis of red blood cells can occur within 1 hour. At 80 µM, hemolysis of red blood cells can occur within 1 hour. At 1 µM, 100% hemolysis occurs within 1 hour, and at 0.5 µM, 50% hemolysis occurs. At a concentration of 90 µM, treatment for 1 hour did not cause hemolysis of human red blood cells.|||Dermaseptin I and related peptides: The text describes the hemolysis experimental methods, but does not explicitly state whether their hemolytic activity is significant. DS bII (adenoregulin): It is clearly stated that at the highest tested concentration (250 ug/ml), it does not cause hemolysis, indicating that it has no significant toxicity to mammalian red blood cells." "J Biol Chem . 1994 Dec 16;269(50):31635-41.|||Eur J Biochem. 1994 Jan 15;219(1-2):145-154.|||8306981|||J Biol Chem. 1994;269(50):31635-31641.|||Eur J Biochem. 1994 Jan 15;219(1-2):145-154.|||J Biol Chem. 1994;269(50):31635-31641.PubMed." 29 FPDB01658 AP00203|||Antimicrobial peptide 1|||DRAMP01016|||Antimicrobial peptide 1|||AP00203|||DRAMP01016|||AP00203 QCIGNGGRCNENVGPPYCCSGFCLRQPGQGYGYCKNR Anti-fungi A. brassicola, activity value is IC50 = 20 ug/ml||Anti-A.pisi, activity value is IC50 = 200 ug/ml||Anti-B. cinerea, activity value is IC50 = 60 ug/ml||Anti-C. beticola, activity value is IC50 = 10 ug/ml||Anti-C. lindemuthianum, activity value is IC50 = 6 ug/ml||Anti-F. culmorum, activity value is IC50 = 30 ug/ml||Anti-F. oxysporum, activity value is IC50 = 15 ug/ml||Anti-N. haematococca, activity value is IC50 = 15 ug/ml||Anti-P. betae, activity value is IC50 = 25 ug/ml||Anti-P.tritici-repentis, activity value is IC50 = 300 ug/ml||Anti-P. oryzae, activity value is IC50 = 6 ug/ml||Anti-R. solani, activity value is IC50 = 60 ug/ml||Anti-V. dahliae, activity value is IC50 = 12 ug/ml||Anti-V. inaequalis, activity value is IC50 = 12 ug/ml||Anti-B. megaterium, activity value is IC50 = 6 ug/ml||Anti-E.carotovora, activity value is IC50 > 500 ug/ml||Anti-E.coli, activity value is IC50 > 500 ug/ml||Anti-and S. lutea, activity value is IC50 = 100 ug/ml||Antibacterial||Antifungal||Anti-Alternaria brassicola, activity value is MIC = 20 ug/ml||Anti-Ascochyta pisi, activity value is MIC = 200 ug/ml||Anti-Botrytis cinerea, activity value is MIC = 50 ug/ml||Anti-Cercospora beticola, activity value is MIC = 10 ug/ml||Anti-Colletotrichum lindemuthianum, activity value is MIC = 6 ug/ml||Anti-Fusarium culmorum, activity value is MIC = 30 ug/ml||Anti-Fusarium oxysporum f.sp.pisi, activity value is MIC = 15 ug/ml||Anti-Fusarium oxysporum f.sp.lycopersici, activity value is MIC = 200 ug/ml||Anti-Nectria haematococca, activity value is MIC = 15 ug/ml||Anti-Phoma betae, activity value is MIC = 25 ug/ml||Anti-Pyrenophora tritici-repentis, activity value is MIC = 300 ug/ml||Anti-Pyricularia oryzae, activity value is MIC = 6 ug/ml||Anti-Rhizoctonia solani, activity value is MIC = 60 ug/ml||Anti-Verticillium dahliae, activity value is MIC = 12 ug/ml||Anti-Venturia inequalis, activity value is MIC = 12 ug/ml||Anti-Sarcina lutea, activity value is MIC = 100 ug/ml||Anti-B.megaterium, activity value is MIC = 6 ug/ml||Anti-Gram+||candidacidal Garden four-o'clock Mirabilis jalapa|||Mirabilis jalapa [Garden four-o-clock]|||Mirabilis jalapa (Garden four-o'clock)|||Mirabilis jalapa [Garden four-o-clock]|||Garden four-o'clock Mirabilis jalapa|||Mirabilis jalapa (Garden four-o'clock)|||Garden four-o'clock Mirabilis jalapa Bridge N/A "J Biol Chem . 1992 Feb 5;267(4):2228-33.|||1733929 , 7647302|||J. Biol. Chem. 1992;267:2228-2233.|||1733929|||1733929 , 7647302|||J. Biol. Chem. 1992; 267: 2228-2233.|||J. Biol. Chem. 1992; 267: 2228-2233. PubMed." 37 FPDB01664 AP00215|||Tachyplesin-2|||Tachyplesin II|||TP II|||DRAMP02939|||Tachyplesin-2|||AP00215|||DRAMP02939|||AP00215 RWCFRVCYRGICYRKCR Anti-Gram- S. typhimurium LT2 or 1102, activity value is MIC = 1.6||Anti-E. coli K12, activity value is MIC = 3.1 ug/ml||Anti-S. Minnesota 1114W or R595, activity value is MIC = 1.6||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 1.6||Anti-and C. albicans M9, activity value is MIC = 3.1 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 0.5||Anti-Escherichia coli DC2 CGSC 7139, activity value is MIC = 0.125||Anti-S. aureus ATCC 25923, activity value is MIC = 1||Anti-S. aureus ATCC 6538, activity value is MIC = 4||Anti-Escherichia coli ML-35p, activity value is MIC = 0.062 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 1 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 0.5 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 8 uM||Anti-Staphylococcus aureus 209P, activity value is MIC = 0.5 uM||Anti-B. subtilis B-886, activity value is MIC = 0.5 uM||Anti-M. luteus B-1314, activity value is MIC = 1 uM||Antimicrobial||Antibacterial||Antifungal||Antifungal ; Candida albicans M9||Anti-Gram+ & Gram-||candidacidal Japanese Tachypleus tridentatus|||Tachypleus tridentatus|||Synthetic construct|||Limulus polyphemus [Atlantic horseshoe crab]|||Tachypleus tridentatus (Japanese horseshoe crab)|||Japanese Tachypleus tridentatus|||Bacillus subtilis|||Japanese Tachypleus tridentatus Beta||Bridge Human RBCs [Hemolytic concentration 50 (HC50) = 55.4 ± 6.6 uM]|||hRBC (33% hemolysis at 100 uM)|||Weak hemolytic activity (15% hemolysis at 20 μM) "J Biochem . 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||2514185|||31455019|||30486233|||J Biochem. 1989 Oct;106(4):663-668.|||2514185|||J. Biochem. 1989; 106: 663-668. doi: 10.1093/oxfordjournals.jbchem.a122913.|||Org Lett. 2014 Feb 7;16(3):928-31.|||J. Biochem. 1989; 106: 663-668. PubMed" 17 FPDB01667 AP00218|||Protegrin-2|||DRAMP02971|||Protegrin-2|||AP00218|||DRAMP02971|||AP00218 RGGRLCYCRRRFCICV Active against C. albicans .||Anti-L. monocytogenes, activity value is MIC > 25 ug/ml||Anti-E. coli, activity value is MIC > 25 ug/ml||Anti-C. albicans, activity value is MIC > 25 ug/ml||Anti-Listeria moncyrogenes strain EGD, activity value is MIC > 25 ug/ml||Anti-Escherichia coli ML-35, activity value is MIC > 25 ug/ml||Antibacterial||Antifungal||Antimicrobial||Anti-Gram+||Anti-Gram-||Anti-Gram+ & Gram-||Antiviral||candidacidal leukocyte, porcine neutrophil, pig, Sus scrofa|||Sus scrofa|||Sus scrofa (Pig)|||Sus scrofa [pig]|||leukocyte, porcine neutrophil, pig, Sus scrofa|||Sus scrofa (Pig)|||leukocyte, porcine neutrophil, pig, Sus scrofa Beta||Bridge N/A Cho Y et al., 1998|||8335113|||FEBS Lett. 1993 Jul 26;327(2):231-236.|||8335113|||Biochem Biophys Res Commun. 1993 Nov 15;196(3):1363-8||Cho Y et al., 1998|||FEBS Lett. 1993 Jul 26;327(2):231-236.Biochem Biophys Res Commun. 1993 Nov 15;196(3):1363-1368.|||Biochem Biophys Res Commun. 1993 Nov 15;196(3):1363-8||Cho Y et al., 1998|||Biochem Biophys Res Commun. 1993 Nov 15;196(3):1363-8 16 FPDB01668 AP00219|||Protegrin-3|||DRAMP02972|||Protegrin-3|||AP00219|||DRAMP02972|||AP00219 RGGGLCYCRRRFCVCVGR More active against a mprF mutant strain . Active against C. albicans .||Antibacterial||Antifungal||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal ; L. monocytogenes||E. coli||C. albicans||: More active against a mprF mutant strain . Active against C. albicans .||Anti-Gram+ & Gram-||Antiviral||candidacidal porcine neutrophil, pig, Sus scrofa|||Sus scrofa [pig]|||Sus scrofa (Pig)|||porcine neutrophil, pig, Sus scrofa|||Sus scrofa (Pig)|||porcine neutrophil, pig, Sus scrofa Beta||Bridge N/A Peschel et al., 2001||Cho Y et al., 1998|||8335113|||FEBS Lett. 1993 Jul 26;327(2):231-236.|||8335113|||FEBS Lett. 1993; 327:231-236||Peschel et al., 2001||Cho Y et al., 1998|||FEBS Lett. 1993 Jul 26;327(2):231-236.|||FEBS Lett. 1993; 327:231-236||Peschel et al., 2001||Cho Y et al., 1998|||FEBS Lett. 1993; 327:231-236 18 FPDB01670 AP00221|||DRAMP02974|||AP00221|||DRAMP02974 " RGGRLCYCRPRFCVCVGR" More active against a mprF mutant strain . Active against C. albicans .||Antimicrobial||Antibacterial||Antifungal||Anti-Gram+ & Gram-||Antiviral||candidacidal Pig, Sus scrofa|||Sus scrofa (Pig)|||Pig, Sus scrofa|||Sus scrofa (Pig)|||Pig, Sus scrofa Beta||Bridge N/A Peschel et al., 2001||Cho Y et al., 1998|||FEBS Lett. 1995 Jul 17;368(2):197-202.|||FEBS Lett. 1995; 368:197-202||Peschel et al., 2001||Cho Y et al., 1998|||FEBS Lett. 1995 Jul 17;368(2):197-202.|||FEBS Lett. 1995; 368:197-202||Peschel et al., 2001||Cho Y et al., 1998|||FEBS Lett. 1995; 368:197-202 18 FPDB01684 AP00235|||Tracheal antimicrobial peptide precursor|||DRAMP02878|||Tracheal antimicrobial peptide precursor|||AP00235|||AP00235 NPVSCVRNKGICVPIRCPGSMKQIGTCVGRAVKCCRKK Anti-E. coli D31, activity value is MIC = 12||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 12||Anti-S. aureus ATCC 25923, activity value is MIC = 25||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 25||Anti-C. albicans ATCC 14053, activity value is MIC = 6||Antibacterial||Antifungal||Anti-Escherichia coli D31, activity value is MIC = 12||Anti-Klebsiella pneumoniae 13883, activity value is MIC = 12||Anti-Pseudomonas aeruginosa 27853, activity value is MIC = 25||Anti-K. pneumoniae 13883, activity value is MIC = 12||Anti-Staphylococcus aureus 25923, activity value is MIC = 25||Anti-Candida ablicans, activity value is MIC = 6||Anti-Gram+ & Gram-||candidacidal mucosal epithelial cells, airway, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine)|||Bos taurus [Bovine]|||mucosal epithelial cells, airway, Bos taurus|||mucosal epithelial cells, airway, Bos taurus Beta N/A "Comparative Study Proc Natl Acad Sci U S A . 1991 May 1;88(9):3952-6. doi: 10.1073/pnas.88.9.3952.|||2023943|||Proc Natl Acad Sci U S A. 1993 May 15;90(10):4596-4600.|||2023943|||Proc Natl Acad Sci U S A. 1991 May 1;88(9):3952-6. doi: 10.1073/pnas.88.9.3952.|||Proc Natl Acad Sci U S A. 1991 May 1;88(9):3952-6. PubMed" 38 FPDB01696 AP00264|||Heterophil peptide CHP1|||DRAMP03642|||AP00264|||AP00264 GRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIR Anti-C. albicans, activity value is MIC = 8 ug/ml||Anti-B. avium, activity value is MIC = 16 ug/ml||Anti-E. coli, activity value is MIC = 16 ug/ml||Anti-S. enteriditis, activity value is MIC = 16 ug/ml||Anti-S. typhimurium, activity value is MIC = 4 ug/ml||Anti-C. jejuni, activity value is MIC = 2 ug/ml||Anti-P-multocida, activity value is MIC > 16 ug/ml||Anti-M. gallisepticum, activity value is MIC = 16 ug/ml||Antibacterial||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.7 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 0.7 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Gallus gallus|||Gallus gallus [Chicken]|||Gallus gallus (Chicken)|||Gallus gallus|||Gallus gallus Bridge N/A "J Leukoc Biol . 1994 Nov;56(5):661-5. doi: 10.1002/jlb.56.5.661.|||7964174|||J Leukoc Biol. 1994 Nov;56(5):661-665.|||J. Leukoc. Biol. 1994; 56: 661-665. doi: 10.1002/jlb.56.5.661.|||J. Leukoc. Biol. 1994; 56: 661-665. PubMed." 39 FPDB01697 AP00265|||DRAMP18711|||AP00265|||DRAMP18711 " GRKSDCFRKNGFCAFLKCPYLTLISGLCSFHLC" Anti-C. albicans, activity value is MIC = 16 ug/ml||Anti-B. avium, activity value is MIC = 16 ug/ml||Anti-E. coli, activity value is MIC = 16 ug/ml||Anti-S. enteriditis, activity value is MIC = 8 ug/ml||Anti-S. typhimurium, activity value is MIC = 8 ug/ml||Anti-C. jejuni, activity value is MIC = 4 ug/ml||Anti-P-multocida, activity value is MIC > 16 ug/ml||Anti-M. gallisepticum, activity value is MIC = 16 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||No MICs found in DRAMP database||Anti-Gram+ & Gram-||candidacidal Gallus gallus|||Gallus gallus (Chicken)|||Gallus gallus|||Gallus gallus (Chicken) Bridge No hemolysis information or data found in the reference(s) presented in this entry "J Leukoc Biol . 1994 Nov;56(5):661-5. doi: 10.1002/jlb.56.5.661.|||J. Leukoc. Biol. 1994; 56: 661-665.|||J. Leukoc. Biol. 1994; 56: 661-665. doi: 10.1002/jlb.56.5.661.|||J. Leukoc. Biol. 1994; 56: 661-665.|||J. Leukoc. Biol. 1994; 56: 661-665. PubMed." 33 FPDB01698 AP00266 " GKREKCLRRNGFCAFLKCPTLSVISGTCSRFQVCCKTLLG" Anti-C. albicans, activity value is MIC = 8 ug/ml||Anti-B. avium, activity value is MIC = 8 ug/ml||Anti-E. coli, activity value is MIC = 8 ug/ml||Anti-S. enteriditis, activity value is MIC = 8 ug/ml||Anti-S. typhimurium, activity value is MIC = 4 ug/ml||Anti-C. jejuni, activity value is MIC = 2 ug/ml||Anti-P-multocida, activity value is MIC > 16 ug/ml||Anti-M. gallisepticum, activity value is MIC = 8 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Meleagris gallopavo Bridge N/A "J Leukoc Biol . 1994 Nov;56(5):661-5. doi: 10.1002/jlb.56.5.661.|||J. Leukoc. Biol. 1994; 56: 661-665. doi: 10.1002/jlb.56.5.661.|||J. Leukoc. Biol. 1994; 56: 661-665. PubMed." 40 FPDB01702 AP00272|||DRAMP03366|||AP00272|||DRAMP03366 DQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS Anti-both Gram-positive and negative bacteria P. aeruginosa, activity value is MIC = 50 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Gram+ & Gram-||Antiviral||candidacidal kidney, tongue, esophagus, and trachea, Mouse, Mus musculus|||Mus musculus (Mouse)|||kidney, tongue, esophagus, and trachea, Mouse, Mus musculus|||Mus musculus (Mouse) Bridge N/A "FEBS Lett . 1997 Aug 11;413(1):45-9. doi: 10.1016/s0014-5793(97)00875-2.|||FEBS Lett. 1997 Aug 11;413(1):45-49.|||FEBS Lett. 1997 Aug 11;413(1):45-9. doi: 10.1016/s0014-5793(97)00875-2.|||FEBS Lett. 1997 Aug 11;413(1):45-49.|||. 1965 Jun 15;21(6):307-8. doi: 10.1007/BF02144681.|||FEBS Lett. 1997 Aug 11;413(1):45-9. Pub-Med." 37 FPDB01704 AP00279|||Clavanin-D|||DRAMP02600|||Clavanin-D|||AP00279|||DRAMP02600|||AP00279 AFKLLGRIIHHVGNFVYGFSHVF Anti-L. monocytogenes EGD and C. albicans in radial diffusion assays . More active than Clavanin A or B . Recent tests reveled activity against E. coli ATCC 25922, activity value is MIC = 64 ug/ml||Anti-E.faecalis ATCC 29212, activity value is MIC = 128 ug/ml||Anti-S.aureus ATCC 43300, activity value is MIC = 128 ug/ml||Anti-and C. albicans ATCC 10231, activity value is MIC = 16 ug/ml||Antibacterial||Antifungal||Antimicrobial||Anti-Gram+||Antifungal ; E.coli||L.monocytes||C.albicans||Anti-Gram+ & Gram-||candidacidal invertebrate Styela clava|||Styela clava [Sea squirt]|||Styela clava (Sea squirt)|||invertebrate Styela clava|||Styela clava (Sea squirt)|||invertebrate Styela clava Alpha helix N/A "FEBS Lett . 1997 Jan 3;400(2):158-62. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||see ref||Miller et al., 2021|||9001389|||FEBS Lett. 1997 Jun 30;410(2-3):490-492.|||9001389|||FEBS Lett. 1997; 400:158-162. PubMed.||dose dependent, see Fig. 6 in the ref||see ref||Miller et al., 2021|||FEBS Lett. 1997 Jun 30;410(2-3):490-492. FEBS Lett. 1997 Jan 3;400(2):158-162.|||FEBS Lett. 1997; 400:158-162. PubMed." 23 FPDB01724 AP00307|||Buforin-1|||DRAMP01162|||Buforin-1|||AP00307|||DRAMP01162|||AP00307 AGRGKQGGKVRAKAKTRSSRAGLQFPVGRVHRLLRKGNY Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-S. mutans, activity value is MIC = 8||Anti-P. putida, activity value is MIC = 4 ug/ml||Anti-E. coli, activity value is MIC = 8 ug/ml||Anti-S. typhimurium, activity value is MIC = 4 ug/ml||Anti-Serratia sp, activity value is MIC = 8 ug/ml||Anti-and S. cerevisiae, activity value is MIC = 4 ug/ml||Antibacterial||Antifungal||Anti-Bacillus subtilis, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||Anti-Streptococcus mutans, activity value is MIC = 8 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 4 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 4 ug/ml||Anti-Escherichia coli, activity value is MIC = 8 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 4 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 4 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC = 4 ug/ml||Anti-Candida albicans, activity value is MIC = 4 ug/ml||Anti-Gram+ & Gram-||candidacidal stomach, Bufo bufo gargarizans, Asia; Also in: Homo sapiens; Bos taurus; Sus scrofa|||Bufo gargarizans [Asian toad]|||Bufo gargarizans (Asian toad) (Bufo bufo gargarizans)|||Bufo gargarizans [Asian toad]|||stomach, Bufo bufo gargarizans, Asia; Also in: Homo sapiens; Bos taurus; Sus scrofa|||Bufo gargarizans (Asian toad) (Bufo bufo gargarizans)|||stomach, Bufo bufo gargarizans, Asia; Also in: Homo sapiens; Bos taurus; Sus scrofa N/A N/A "Comparative Study Biochem Biophys Res Commun . 1996 Jan 5;218(1):408-13. doi: 10.1006/bbrc.1996.0071.|||8573171|||Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.|||8946958|||8573171|||Biochem. Biophys. Res. Commun. 1996; 218:408-413. PubMed|||Biochem. Biophys. Res. Commun. 1996; 218:408-413. PubMed" 39 FPDB01766 AP00369|||Antibacterial peptide PMAP-23|||PMAP-23|||DNS-PMAP23|||AP00369 RIIDLLWRVRRPQKPKFVTVWVR Anti-E. coli ML35 or ATCC 25922, activity value is MIC = 2||Anti-S. typhimurium ATCC 14028, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 16 uM||Anti-B. megaterium local isolate, activity value is MIC = 2 uM||Anti-and S. aureus ATCC 25923, activity value is MIC = 4 uM||Antibacterial||Anti-Gram+ & Gram-||Antifungal||candidacidal Pig, Sus scrofa|||Sus scrofa [Pig]|||Sus scrofa|||Homo sapiens [Human]|||Pig, Sus scrofa Helix E. coli ML35 ( MIC = 2 uM), E. coli ATCC 25922 ( MIC = 4 uM), S. typhimurium ATCC 14028 ( MIC = 8 uM), P.aeruginosa ATCC 27853 ( MIC = 16 uM), B. megaterium ( MIC = 2 uM), S. aureus ATCC 25923 ( MIC = 4 uM)|||E. coli BW25113 (MIC- 2.5 uM)|||Human RBC 50% haemolysis at 29 uM|||At a concentration of 100 uM, PMAP-23 also does not induce hemolysis of human red blood cells. "J Biol Chem . 1994 Mar 18;269(11):7855-8.||see ref|||8132502|||31026481|||27935673|||J. Biol. Chem. 1994; 269: 7855-7858. PubMed.||see ref|||J. Biol. Chem. 1994; 269: 7855-7858. PubMed." 23 FPDB01792 AP00400|||DRAMP01627|||Skin peptide tyrosine-tyrosine|||AP00400|||DRAMP01627 YPPKPESPGEDASPEEMNKYLTALRHYINLVTRQRY Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anti-Aeromonas caviae, activity value is MIC = 40 ug/ml||Anti-Escherichia coli, activity value is MIC = 10 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 10 ug/ml||Anti-Nocardia brasiliensis, activity value is MIC = 20 ug/ml||Anti-Candida albicans, activity value is MIC = 15 ug/ml||Anti-Microsporum canis, activity value is MIC = 10 ug/ml||Anti-Tricophyton rubrum, activity value is MIC = 15 ug/ml||Anti-Arthroderma simii, activity value is MIC = 10 ug/ml||Anti-Aspergillus fumigatus, activity value is MIC = 80 ug/ml||Anti-Aspergillus niger, activity value is MIC > 100 ug/ml skin, the South American arboreal frog Phyllomedusa bicolor|||Phyllomedusa bicolor (Two-colored leaf frog)|||Phyllomedusa bicolor [Two-colored leaf frog]|||skin, the South American arboreal frog Phyllomedusa bicolor|||Phyllomedusa bicolor (Two-colored leaf frog) N/A N/A Proc. Natl. Acad. Sci. U.S.A. 1994; 91:10295-10299|||Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10295-10299.|||7937944|||Proc. Natl. Acad. Sci. U.S.A. 1994; 91:10295-10299 36 FPDB01793 AP00401 GFTQGVRNSQSCRRNKGICVPIRCPGSMRQIGTCLGAQVKCCRRK Anti-Gram+ & Gram-||Antifungal||candidacidal tongue., Bovine Bos taurus? Bridge N/A Science 1995; 267:1645-1648 45 FPDB01797 AP00407|||Ranatuerin-2ONa|||Ranatuerin-2ONa|||AP00407|||AP00407 GLMDTVKNAAKNLAGQMLDKLKCKITGSC Anti-Gram-||Antifungal||candidacidal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 50 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 200 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 100 uM Rana onca, North America|||Lithobates onca|||Lithobates onca|||Rana onca, North America|||Rana onca, North America N/A "The document mentions that the hemolytic activity of ranatuerin-2ONa on human red blood cells is as follows: - Half-maximal lysis concentration (LC₅₀): 90 μM.|||Human erythrocytes (50% Hemolysis at 90 uM|||Human erythrocytes (50% Hemolysis at 90 uM|||LC₅₀=90" "Comp Biochem Physiol C Toxicol Pharmacol . 2010 Apr;151(3):313-7. doi: 10.1016/j.cbpc.2009.12.004. Epub 2009 Dec 31.|||20044030|||20044030|||Comp Biochem Physiol C Toxicol Pharmacol . 2010 Apr;151(3):313-7. doi: 10.1016/j.cbpc.2009.12.004. PubMed.|||Comp Biochem Physiol C Toxicol Pharmacol . 2010 Apr;151(3):313-7. doi: 10.1016/j.cbpc.2009.12.004. PubMed." 29 FPDB01812 AP00424|||XT-1|||DRAMP02130|||XT-1|||AP00424|||AP00424 GFLGPLLKLAAKGVAKVIPHLIPSRQQ Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-E.coli, activity value is MIC = 6 uM||Anti-Candida albicans, activity value is MIC = 50 uM||Anti-Escherichia coli, activity value is MIC = 6 uM Diploid clawed frog Silurana tropicalis, (formerly) Xenopus tropicalis , Africa|||Xenopus tropicalis [Western clawed frog]|||Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)|||Xenopus tropicalis [Western clawed frog]|||Diploid clawed frog Silurana tropicalis, (formerly) Xenopus tropicalis , Africa|||Diploid clawed frog Silurana tropicalis, (formerly) Xenopus tropicalis , Africa N/A "Among the seven antimicrobial peptides (XT-1 to XT-7) secreted by the skin, some exhibit hemolytic activity against human erythrocytes, with the following hemolytic values (HC₅₀, i.e., the peptide concentration that causes 50% hemolysis): -XT-1: 90 µM -XT-7: 70 µM -XT-2, XT-4, XT-5, and XT-6: No hemolytic activity was observed at the tested concentrations (up to 150 µM or 400 µM), and they are labeled as “>150” or not determined (ND).|||hRBC (HC50 = 90 uM)|||In Biochimica et Biophysica Acta 2001, among the antimicrobial peptides isolated from the skin secretions of the tropical clawed frog (Xenopus tropicalis), XT-1 had an HC₅₀ of 90 μM against human red blood cells, XT-7 had an HC₅₀ of 70 μM against human red blood cells, the hemolytic activity of XT-2 was not measured, and XT-4, XT-5, and XT-6 all had an HC₅₀ greater than 150 μM against human red blood cells.|||hRBC (HC50 = 90 uM)|||HC₅₀=90" "Biochim Biophys Acta . 2001 Nov 26;1550(1):81-9. doi: 10.1016/s0167-4838(01)00272-2.|||11738090|||Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.||Ref.11738090|||11738090|||Biochim Biophys Acta 2001 Nov 26;1550(1):81-9. PubMed.|||Biochim Biophys Acta 2001 Nov 26;1550(1):81-9. PubMed." 27 FPDB01819 AP00433|||DRAMP03587|||AP00433|||DRAMP03587 SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSV In vitro MIC against E. coli||E. faecalis and S. aureus at ~1 ug.mL||and at 10 ug.mL C. albicans. Also active against P. acnes .||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||Proteolytic||Anti-Gram+ & Gram-||candidacidal Eccrine sweat glands, skin, Homo sapiens|||Homo sapiens (Human)|||Eccrine sweat glands, skin, Homo sapiens|||Homo sapiens (Human) Helix||Alpha helix N/A "Nat Immunol . 2001 Dec;2(12):1133-7. doi: 10.1038/ni732.||ref|||Nat Immunol. 2001 Dec;2(12):1133-1137.|||Nat. Immunol. 2001; 2:1133-1137. PubMed||ref|||Nat Immunol. 2001 Dec;2(12):1133-1137.Biochem Biophys Res Commun. 2007 Jun 15;357(4):828-833.BMB Rep. 2010 May;43(5):362-368.|||Nat. Immunol. 2001; 2:1133-1137. PubMed" 47 FPDB01822 AP00437|||DRAMP18717|||Charybdotoxin|||AP00437|||DRAMP18717 EFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS Antimicrobial activity was only established recently based on the gamma-core motif. Diffusion assay: active against B. subtilis||S. aureus||E. coli||and C. albicans (pH 7.5>pH 5.5).||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||Gram-positive bacteria: Bacillus subtilis (Inhibition zone=4 mm completely inhibit in PH5.5||Inhibition zone=7 mm incompletely inhibit and Inhibition zone=6 mm in PH7.5 completely inhibit at 10 ug/well)||Staphylococcus aureus (Inhibition zone=3 mm incompletely inhibit in PH5.5||Inhibition zone=6 mm incompletely inhibit and Inhibition zone=1 mm completely inhibit in PH7.5 at 10 ug/well);##Gram-negative bacteria: Escherichia coli (Inhibition zone=2 mm incompletely inhibit in PH5.5||Inhibition zone=8 mm incompletely inhibit in PH7.5 at 10 ug/well);##Fungi: Candida albicans (Inhibition zone=13 mm completely inhibit in PH5.5||Inhibition zone=15 mm in PH7.5 completely inhibit at 10 ug/well).||Anti-Gram+ & Gram-||candidacidal Identified based on gamma-core motif. Leiurus quinquestriatus hebraeus|||Leiurus quinquestriatus hebraeus|||Leiurus quinquestriatus hebraeus [Yellow scorpion]|||Identified based on gamma-core motif. Leiurus quinquestriatus hebraeus|||Leiurus quinquestriatus hebraeus Combine Helix and Beta structure No hemolysis information or data found in the reference(s) presented in this entry Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.|||Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.|||15118082|||Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.||Ref.15118082 37 FPDB01824 AP00439|||DRAMP03411|||Neutrophil defensin 4|||AP00439|||DRAMP03411 VTCFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ Anti-S. aureus, activity value is IC50 = 6.5 ug/ml||Anti-S. pyogenes, activity value is IC50 = 5.9 ug/ml||Anti-E. faecalis, activity value is IC50 = 9.2 ug/ml||Anti-E. coli, activity value is IC50 = 11.8 ug/ml||Anti-Salmonella serotype k eld, activity value is IC50 = 9.8 ug/ml||Anti-K. oxytoca, activity value is IC50 = 13.1 ug/ml||Anti-P. aeruginosa, activity value is IC50 = 32.7 ug/ml||Anti-C. albicans, activity value is IC50 = 81.7 ug/ml||Anti-and C. neoformans, activity value is IC50 = 35.9 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Gram+ & Gram-||candidacidal Syrian Hamster, Mesocricetus auratus|||Mesocricetus auratus (Golden hamster)|||Mesocricetus auratus [Golden hamster]|||Syrian Hamster, Mesocricetus auratus|||Mesocricetus auratus (Golden hamster) Bridge N/A "Infect Immun . 1996 Nov;64(11):4444-9. doi: 10.1128/iai.64.11.4444-4449.1996.|||Infect Immun. 1996 Nov;64(11):4444-4449.|||8890190|||Infect. Immun. 1996; 64: 4444-4449. PubMed.|||Infect Immun. 1996 Nov;64(11):4444-4449.|||Infect. Immun. 1996; 64: 4444-4449. PubMed." 33 FPDB01825 AP00440|||DRAMP03408|||Neutrophil defensin 1|||AP00440|||DRAMP03408 VTCFCRRRGCASRERHIGYCRFGNTIYRLCCRR activity value is IC50 = 0.8 ug/ml||Anti-S. pyogenes, activity value is IC50 = 0.6 ug/ml||Anti-E. faecalis, activity value is IC50 = 0.4 ug/ml||Anti-E. coli, activity value is IC50 = 0.8 ug/ml||Anti-Salmonella serotype k eld, activity value is IC50 = 1.2 ug/ml||Anti-K. oxytoca, activity value is IC50 = 4.3 ug/ml||Anti-P. aeruginosa, activity value is IC50 = 46.2 ug/ml||Anti-C. albicans, activity value is IC50 = 4.6 ug/ml||Anti-and C. neoformans, activity value is IC50 = 1.8 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||candidacidal Golden hamster or Syrian hamster, Mesocricetus auratus|||Mesocricetus auratus (Golden hamster)|||Mesocricetus auratus [Golden hamster]|||Golden hamster or Syrian hamster, Mesocricetus auratus|||Mesocricetus auratus (Golden hamster) Bridge N/A "Infect Immun . 1996 Nov;64(11):4444-9. doi: 10.1128/iai.64.11.4444-4449.1996.|||Infect Immun. 1996 Nov;64(11):4444-4449.|||8890190|||Infect. Immun. 1996; 64: 4444-4449. PubMed.|||Infect Immun. 1996 Nov;64(11):4444-4449.|||Infect. Immun. 1996; 64: 4444-4449. PubMed." 33 FPDB01826 AP00441|||DRAMP03409|||Neutrophil defensin 2|||DRAMP03409 CFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ activity value is IC50 = 18.2 ug/ml||Anti-S. pyogenes, activity value is IC50 = 6.1 ug/ml||Anti-E. faecalis, activity value is IC50 = 12 ug/ml||Anti-E. coli, activity value is IC50 = 30.4 ug/ml||Anti-Salmonella serotype k eld, activity value is IC50 = 24.3 ug/ml||Anti-K. oxytoca, activity value is IC50 = 20.2 ug/ml||Anti-P. aeruginosa, activity value is IC50 = 25.8 ug/ml||Anti-and C. albicans, activity value is IC50 = 38 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Gram+ & Gram-||candidacidal Golden hamster or Syrian hamster, Mesocricetus auratus|||Mesocricetus auratus (Golden hamster)|||Mesocricetus auratus [Golden hamster]|||Mesocricetus auratus (Golden hamster) Bridge N/A "Infect Immun . 1996 Nov;64(11):4444-9. doi: 10.1128/iai.64.11.4444-4449.1996.|||Infect Immun. 1996 Nov;64(11):4444-4449.|||8890190|||Infect Immun. 1996 Nov;64(11):4444-4449.|||Infect. Immun. 1996; 64: 4444-4449. PubMed." 31 FPDB01827 AP00442|||DRAMP03410|||Neutrophil defensin 3|||AP00442|||DRAMP03410 VTCFCRRRGCASRERLIGYCRFGNTIYGLCCRR activity value is IC50 = 0.55 ug/ml||Anti-S. pyogenes, activity value is IC50 = 0.3 ug/ml||Anti-E. faecalis, activity value is IC50 = 0.7 ug/ml||Anti-E. coli, activity value is IC50 = 11 ug/ml||Anti-Salmonella serotype k eld, activity value is IC50 = 1.8 ug/ml||Anti-K. oxytoca, activity value is IC50 = 2.6 ug/ml||Anti-P. aeruginosa, activity value is IC50 = 15.6 ug/ml||Anti-C. albicans, activity value is IC50 = 12.9 ug/ml||Anti-and C. neoformans, activity value is IC50 = 0.9 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||candidacidal Golden hamster or Syrian hamster, Mesocricetus auratus|||Mesocricetus auratus (Golden hamster)|||Mesocricetus auratus [Golden hamster]|||Golden hamster or Syrian hamster, Mesocricetus auratus|||Mesocricetus auratus (Golden hamster) Bridge N/A "Infect Immun . 1996 Nov;64(11):4444-9. doi: 10.1128/iai.64.11.4444-4449.1996.|||Infect Immun. 1996 Nov;64(11):4444-4449.|||8890190|||Infect. Immun. 1996; 64: 4444-4449. PubMed.|||Infect Immun. 1996 Nov;64(11):4444-4449.|||Infect. Immun. 1996; 64: 4444-4449. PubMed." 33 FPDB01831 AP00448|||DRAMP03025 INLKAIAALAKKLL Anti-E. coli, activity value is MIC = 25 uM||Anti-fungi A. longipes (50% inhibition, activity value is IC50 = 3 ug/ml||Anti-B. cinerea, activity value is IC50 = 6 ug||Anti-C. sphaerospermum, activity value is IC50 = 1 ug||Anti-F. culmorum, activity value is IC50 = 1 ug||Anti-P. digitatum, activity value is IC50 = 3 ug||Anti-T. viride, activity value is IC50 = 6 ug||Anti-and V. alboatrum, activity value is IC50 = 6 ug||Anti-S. xylosus, activity value is MIC = 2 ug/ml||Anti-S. alactolyticus, activity value is MIC = 16 ug/ml||Anti-C. koseri, activity value is MIC = 4 ug/ml||Anti-E. coli BL21 or JM109 Amp, activity value is MIC = 8 ug/ml||Anti-K.pneumoniae CCRC10694, activity value is MIC = 128 ug/ml||Anti-S. Choleraesuis, activity value is MIC = 32 ug/ml||Anti-S. typhimurium CCRC12947, activity value is MIC = 32 ug/ml||Anti-V. parahamelytics CCRC10806, activity value is MIC = 64 ug/ml||Anti-and P.aeruginosa, activity value is MIC = 128 ug/ml||Antimicrobial||Antibacterial||Anti-gram+||Anti-gram-||Anti-Gram+ & Gram-||Antifungal||candidacidal Hornet Vespa mandarinia; venom gland, the social wasp Vespa tropica; wasp venom, Vespa magnifica|||Hornet Vespa mandarinia; venom gland, the social wasp Vespa tropica; wasp venom, Vespa magnifica, Asia|||Vespa magnifica Helix N/A Biomed. Res. 1981; 2: 447-449|||Biochem Pharmacol. 2005 Jul 15;70(2):209-219.Chem Biol Drug Des. 2017 Mar;89(3):327-338. doi: 10.1111/cbdd.12864. 14 FPDB01840 AP00460|||Brevinin-1Pb precursor|||DRAMP02077|||Brevinin-1Pb precursor|||AP00460|||DRAMP02077|||AP00460 FLPIIAGIAAKVFPKIFCAISKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-Escherichia coli, activity value is MIC = 14 uM||Anti-S. aureus, activity value is MIC = 5 uM||Anti-E. coli, activity value is MIC = 14 uM||Anti-C. albicans, activity value is MIC = 7 uM Northern leopard frog, Rana pipiens, North America|||Rana pipiens [Northern leopard frog]|||Rana luteiventris (Great Basin spotted frog)|||Rana pipiens (Northern leopard frog)|||Rana pipiens [Northern leopard frog]|||Northern leopard frog, Rana pipiens, North America|||Rana pipiens (Northern leopard frog)|||Northern leopard frog, Rana pipiens, North America N/A "The document provides hemolytic values for certain peptide compounds at different concentrations, as follows: -DNal: At a concentration of 100 µM, the hemolysis rate was 7% ± 2.1%. -Peptide 3: At a concentration of 100 µM, the hemolysis rate was 23% ± 0.1%. -Peptide 4: At a concentration of 100 µM, the hemolysis rate was 30% ± 0.2%. -Peptide 8: At a concentration of 100 µM, the hemolysis rate was 24% ± 0.4%. -Peptide 9: At a concentration of 100 µM, the hemolysis rate was 49% ± 4.1%. -Peptide 10: At a concentration of 100 µM, the hemolysis rate was 34% ± 1%. These data indicate that different peptide compounds exhibit varying degrees of hemolytic activity at higher concentrations; some peptides demonstrate a certain level of hemolytic activity, but the overall hemolysis rate remains relatively low, suggesting a favorable safety profile.|||S. aureus ( MIC = 5 uM ), E. coli ( MIC = 14 uM ), C. albicans ( MIC = 7 uM )" "Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||12413397||Ref.10651828|||10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed.|||Ref.10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed." 24 FPDB01841 AP00461|||Brevinin-1La|||AP00461|||DRAMP02089 FLPMLAGLAASMVPKLVCLITKKC Anti-E. coli, activity value is MIC = 50 uM||Anti-S. aureus, activity value is MIC = 6 uM||Anti-C. albicans, activity value is MIC = 12 uM||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic Columbia Spotted Frog, Rana luteiventris ; ALSO: the Oregon spotted frog Rana pretiosa, Noth America|||Rana luteiventris [Spotted frog]|||Columbia Spotted Frog, Rana luteiventris ; ALSO: the Oregon spotted frog Rana pretiosa, Noth America|||Rana luteiventris (Spotted frog) N/A "The document provides hemolytic values of some peptide compounds at different concentrations, as follows: - DNal: at a concentration of 100 μM, the hemolysis rate is 7% ± 2.1%. - Peptide 3: at a concentration of 100 μM, the hemolysis rate is 23% ± 0.1%. - Peptide 4: at a concentration of 100 μM, the hemolysis rate is 30% ± 0.2%. - Peptide 8: at a concentration of 100 μM, the hemolysis rate is 24% ± 0.4%. - Peptide 9: at a concentration of 100 μM, the hemolysis rate is 49% ± 4.1%. - Peptide 10: at a concentration of 100 μM, the hemolysis rate is 34% ± 2%. These data indicate that different peptide compounds exhibit varying hemolytic effects on red blood cells at higher concentrations. Some peptides show certain hemolytic activity, but the overall hemolysis rate is relatively low, suggesting a certain potential for safety." "Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed.|||Dev Comp Immunol. 2011 Jun;35(6):644-649." 24 FPDB01844 AP00464|||Brevinin-1Bb|||DRAMP02092|||Brevinin-1Bb|||AP00464|||DRAMP03918|||DRAMP02092|||AP00464 FLPAIAGMAAKFLPKIFCAISKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 1 uM||Anti-Escherichia coli, activity value is MIC = 3 uM||Antimicrobial||Anti-Gram+||Anti-Gram- Rio Grande leopard frog, Rana berlandieri, North America|||Rana berlandieri [Rio Grande leopard frog]|||Rana berlandieri (Rio Grande leopard frog)|||Rana berlandieri [Rio Grande leopard frog]|||Rio Grande leopard frog, Rana berlandieri, North America|||Synthetic construct (De novo design)|||Rana berlandieri (Rio Grande leopard frog)|||Rio Grande leopard frog, Rana berlandieri, North America N/A "The document provides hemolytic values of some peptide compounds at different concentrations, as follows: - DNal: at a concentration of 100 μM, the hemolysis rate is 7% ± 2.1%. - Peptide 3: at a concentration of 100 μM, the hemolysis rate is 23% ± 0.1%. - Peptide 4: at a concentration of 100 μM, the hemolysis rate is 30% ± 0.2%. - Peptide 8: at a concentration of 100 μM, the hemolysis rate is 24% ± 0.4%. - Peptide 9: at a concentration of 100 μM, the hemolysis rate is 49% ± 4.1%. - Peptide 10: at a concentration of 100 μM, the hemolysis rate is 34% ± 5%. These data indicate that different peptide compounds exhibit varying hemolytic effects on red blood cells at higher concentrations. Some peptides show certain hemolytic activity, but the overall hemolysis rate is relatively low, suggesting a certain potential for safety." "Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed.|||Int J Mol Sci. 2012; 13(11): 15042-15053.|||Eur J Biochem. 2000 Feb;267(3):894-900.|||Eur. J. Biochem. 2000; 267: 894-900. PubMed." 24 FPDB01846 AP00466|||Brevinin-1Bd|||DRAMP02094|||Brevinin-1Bd|||AP00466|||DRAMP02094|||AP00466 FLPAIAGVAAKFLPKIFCAISKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Escherichia coli, activity value is MIC = 7 uM||Anti-##Gram-negative bacterium: Escherichia coli, activity value is MIC = 7 uM Rio Grande leopard frog, Rana berlandieri, North America|||Rana berlandieri [Rio Grande leopard frog]|||Rana berlandieri (Rio Grande leopard frog)|||Rana berlandieri [Rio Grande leopard frog]|||Rio Grande leopard frog, Rana berlandieri, North America|||Rana berlandieri (Rio Grande leopard frog)|||Rio Grande leopard frog, Rana berlandieri, North America N/A "The document provides hemolytic values of some peptide compounds at different concentrations, as follows: - DNal: at a concentration of 100 μM, the hemolysis rate is 7% ± 2.1%. - Peptide 3: at a concentration of 100 μM, the hemolysis rate is 23% ± 0.1%. - Peptide 4: at a concentration of 100 μM, the hemolysis rate is 30% ± 0.2%. - Peptide 8: at a concentration of 100 μM, the hemolysis rate is 24% ± 0.4%. - Peptide 9: at a concentration of 100 μM, the hemolysis rate is 49% ± 4.1%. - Peptide 10: at a concentration of 100 μM, the hemolysis rate is 34% ± 7%. These data indicate that different peptide compounds exhibit varying hemolytic effects on red blood cells at higher concentrations. Some peptides show certain hemolytic activity, but the overall hemolysis rate is relatively low, suggesting a certain potential for safety.|||No hemolysis information or data found in the reference(s) presented in this entry" "Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed.|||Ref.10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed." 24 FPDB01849 AP00469|||Brevinin-1Pa|||DRAMP02097|||Brevinin-1Pa|||AP00469|||DRAMP02097|||AP00469 FLPIIAGVAAKVFPKIFCAISKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 7 uM||Anti-Escherichia coli, activity value is MIC = 14 uM||Anti-##Gram-negative bacterium: Escherichia coli, activity value is MIC = 14 uM Northern leopard frog, Rana pipiens, North America|||Rana pipiens [Northern leopard frog]|||Rana pipiens (Northern leopard frog)|||Rana pipiens [Northern leopard frog]|||Northern leopard frog, Rana pipiens, North America|||Rana pipiens (Northern leopard frog)|||Northern leopard frog, Rana pipiens, North America N/A "The document provides hemolytic values of some peptide compounds at different concentrations, as follows: - DNal: at a concentration of 100 μM, the hemolysis rate is 7% ± 2.1%. - Peptide 3: at a concentration of 100 μM, the hemolysis rate is 23% ± 0.1%. - Peptide 4: at a concentration of 100 μM, the hemolysis rate is 30% ± 0.2%. - Peptide 8: at a concentration of 100 μM, the hemolysis rate is 24% ± 0.4%. - Peptide 9: at a concentration of 100 μM, the hemolysis rate is 49% ± 4.1%. - Peptide 10: at a concentration of 100 μM, the hemolysis rate is 34% ± 10%. These data indicate that different peptide compounds exhibit varying hemolytic effects on red blood cells at higher concentrations. Some peptides show certain hemolytic activity, but the overall hemolysis rate is relatively low, suggesting a certain potential for safety.|||No hemolysis information or data found in the reference(s) presented in this entry" "Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed.|||Ref.10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed." 24 FPDB01850 AP00470|||Brevinin-1Pc|||DRAMP02098|||Brevinin-1Pc|||AP00470|||DRAMP02098|||AP00470 FLPIIASVAAKVFSKIFCAISKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 7 uM||Anti-Escherichia coli, activity value is MIC = 5 uM||Anti-##Gram-negative bacterium: Escherichia coli, activity value is MIC = 5 uM Northern leopard frog, Rana pipiens, North America|||Rana pipiens [Northern leopard frog]|||Rana pipiens (Northern leopard frog)|||Rana pipiens [Northern leopard frog]|||Northern leopard frog, Rana pipiens, North America|||Rana pipiens (Northern leopard frog)|||Northern leopard frog, Rana pipiens, North America N/A "The document provides hemolytic values of some peptide compounds at different concentrations, as follows: - DNal: at a concentration of 100 μM, the hemolysis rate is 7% ± 2.1%. - Peptide 3: at a concentration of 100 μM, the hemolysis rate is 23% ± 0.1%. - Peptide 4: at a concentration of 100 μM, the hemolysis rate is 30% ± 0.2%. - Peptide 8: at a concentration of 100 μM, the hemolysis rate is 24% ± 0.4%. - Peptide 9: at a concentration of 100 μM, the hemolysis rate is 49% ± 4.1%. - Peptide 10: at a concentration of 100 μM, the hemolysis rate is 34% ± 11%. These data indicate that different peptide compounds exhibit varying hemolytic effects on red blood cells at higher concentrations. Some peptides show certain hemolytic activity, but the overall hemolysis rate is relatively low, suggesting a certain potential for safety.|||No hemolysis information or data found in the reference(s) presented in this entry" "Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed.|||Ref.10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed." 24 FPDB01851 AP00471|||Brevinin-1Pd|||DRAMP02099|||Brevinin-1Pd|||AP00471|||DRAMP02099|||AP00471 FLPIIASVAANVFSKIFCAISKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 27 uM||Anti-Escherichia coli, activity value is MIC = 78 uM||Anti-##Gram-negative bacterium: Escherichia coli, activity value is MIC = 78 uM Northern leopard frog, Rana pipiens, North America|||Rana pipiens [Northern leopard frog]|||Rana pipiens (Northern leopard frog)|||Rana pipiens [Northern leopard frog]|||Northern leopard frog, Rana pipiens, North America|||Rana pipiens (Northern leopard frog)|||Northern leopard frog, Rana pipiens, North America N/A "The document provides hemolytic values of some peptide compounds at different concentrations, as follows: - DNal: at a concentration of 100 μM, the hemolysis rate is 7% ± 2.1%. - Peptide 3: at a concentration of 100 μM, the hemolysis rate is 23% ± 0.1%. - Peptide 4: at a concentration of 100 μM, the hemolysis rate is 30% ± 0.2%. - Peptide 8: at a concentration of 100 μM, the hemolysis rate is 24% ± 0.4%. - Peptide 9: at a concentration of 100 μM, the hemolysis rate is 49% ± 4.1%. - Peptide 10: at a concentration of 100 μM, the hemolysis rate is 34% ± 12%. These data indicate that different peptide compounds exhibit varying hemolytic effects on red blood cells at higher concentrations. Some peptides show certain hemolytic activity, but the overall hemolysis rate is relatively low, suggesting a certain potential for safety.|||No hemolysis information or data found in the reference(s) presented in this entry" "Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed.|||Ref.10651828|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||Eur. J. Biochem. 2000; 267: 894-900. PubMed." 24 FPDB01870 AP00504|||Human MUC7 20-Mer|||DRAMP03588|||Human MUC7 20-Mer|||AP00504|||DRAMP03588|||AP00504 LAHQKPFIRKSYKCLHKRCR Anti-Activity was initially reported in a previous study . Active against bacteria A. actinomycetemcomitans, activity value is ED50 = 4.37 uM||Anti-E. coli, activity value is ED50 = 1.61 uM||Anti-P. aeruginosa, activity value is ED50 = 4.41 uM||Anti-S. mutans cariogenic bacteria, activity value is ED50 = 1.39 uM||Anti-P. gingivalis, activity value is ED50 < 1 uM||Anti-and S. gordonii, activity value is MIC = 2.43 uM||Anti-C. albicans DIS or azole resistant, activity value is ED50 = 2.4||Anti-C. glabrata or fluconazole resistant, activity value is ED50 = 5.02||Anti-C. krusei, activity value is ED50 = 5.16 uM||Anti-and C. neoformans CN2 or amphotericin B resistant, activity value is ED50 = 4.05||Anti-and S. cerevisiae, activity value is MIC = 5.23 uM||Antibacterial||Antifungal ; Synthetic construct||Antifungal||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal ; Candida albicans (DIS)||Candida glabrata||Candida krusei||Candida neoformans (CN2)||Candida albicans (azole resistant)||Candida glabrata (Fluconazole resistant )||Candida neoformans ( amphotericin B resistant )||Saccharomyces cerevisiae||Escherichia coli||Anti-Gram+ & Gram-||candidacidal alivary secretions, Homo sapiens|||Synthetic construct|||Homo sapiens (Human)|||alivary secretions, Homo sapiens|||Homo sapiens (Human)|||alivary secretions, Homo sapiens Helix||Alpha helix N/A "Antimicrob Agents Chemother . 2003 Feb;47(2):643-52. doi: 10.1128/AAC.47.2.643-652.2003.|||https://pubmed.ncbi.nlm.nih.gov/12543672|||Antimicrob Agents Chemother 2003 Feb;47(2):643-652.|||12543672|||Antimicrob Agents Chemother 2003 Feb;47(2):643-52. PubMed|||Antimicrob Agents Chemother 2003 Feb;47(2):643-652.|||Antimicrob Agents Chemother 2003 Feb;47(2):643-52. PubMed" 20 FPDB01873 AP00509|||CAMPSQ846|||DRAMP03590|||Calcitermin|||AP00509|||DRAMP03590|||AP00509 VAIALKAAHYHTHKE pH-sensitive: At pH 7.4||it was not active. At pH 5.4||the peptide was active against E. coli||P. aeruginosa||and C. albicans but not S.aureus. Antibacterial activity is enhanced in the presence of Zn2+ (micromolar) against E. coli and L. monocytogenes but not C. albicans. In human nasal fluids||Zn2+ concentrations range from not detected to 12.8 uM. The latter is sufficient to enhance the activity of the peptide.||Antimicrobial||Antibacterial||Anti-Gram+||Antifungal||Anti-Gram-||candidacidal airway secretions, nasal fluid, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||Homo sapiens [Human]|||airway secretions, nasal fluid, Homo sapiens|||Homo sapiens (Human)|||airway secretions, nasal fluid, Homo sapiens Helix||Alpha helix N/A FEBS Lett 2001 Aug 24;504(1-2):5-10|||11522286|||FEBS Lett. 2001 Aug 24;504(1-2):5-10.|||11522286|||FEBS Lett 2001 Aug 24;504(1-2):5-10|||FEBS Lett. 2001 Aug 24;504(1-2):5-10.|||FEBS Lett 2001 Aug 24;504(1-2):5-10 15 FPDB01875 AP00511|||Shepherin I|||DRAMP01046|||Shepherin I|||AP00511|||DRAMP01046|||AP00511 GYGGHGGHGGHGGHGGHGGHGHGGGGHG Anti-IC50: 50% reduction in CFU. active against Gram- E. herbicola, activity value is IC50 = 62 ug/ml||Anti-E. coli, activity value is IC50 < 2.5 ug/ml||Anti-P. putida, activity value is IC50 < 2.5 ug/ml||Anti-P. syringae, activity value is IC50 < 2.5 ug/ml||Anti-S. typhimurium, activity value is IC50 < 2.5 ug/ml||Anti-Serratia sp, activity value is IC50 = 8 ug/ml||Anti-B.subtilis, activity value is IC50 > 100 ug/ml||Anti-S.aureus, activity value is IC50 > 100 ug/ml||Anti-S.mutans, activity value is IC50 > 100 ug/ml||Anti-C. albicans, activity value is IC50 = 8 ug/ml||Anti-C. neoformans, activity value is IC50 < 2.5 ug/ml||Anti-S. cerevisiae, activity value is IC50 = 7 ug/ml||Anti-A. alternata, activity value is IC50 = 7 ug/ml||Anti-A. flavus, activity value is IC50 = 65 ug/ml||Anti-A.fumigatus, activity value is IC50 > 100 ug/ml||Anti-and F. culmorum, activity value is IC50 = 72 ug/ml||Anti-a 2014 paper reported MIC against C. albicans MDM8 or ATCC 90028 or fluconazole-resistant HU 168, activity value is MIC = 12.5||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 6.25 uM||Anti-C. krusei ATCC 6258, activity value is MIC = 50 uM||Anti-C. tropicalis Squibb 1600, activity value is MIC = 1.56 uM||Anti-and S. cerevisiae ATCC 2601, activity value is MIC = 12.5 uM||Erwinia herbicola (IC(50) = 25 ug/ml)||Escherichia coli (IC(50) < 2.5 ug/ml)||Pseudomonas putida (IC(50) < 2.5 ug/ml)||Pseudomonas syringae (IC(50) < 2.5 ug/ml)||Salmonella typhimurium (IC(50) = 65 ug/ml)||Serratia sp. (IC(50) < 2.5 ug/ml)||Candida albicans (IC(50) = 5 ug/ml)||Cryptococcus neoformans (IC(50) < 2.5 ug/ml)||Saccharomyces cerevisiae (IC(50) = 3 ug/ml)||Aspergillus flavus (IC(50) = 60 ug/ml)||Fusarium culmorum (IC(50) = 68 ug/ml)||Antimicrobial||Antibacterial||Anti-Gram-||Antifungal||Antifungal ; Erwinia herbicola (IC(50) = 25 ug/ml)||candidacidal roots, shepherd's purse, Capsella bursa-pastoris|||Capsella bursa-pastoris [Shepherd purse]|||Capsella bursa-pastoris (shepherd's purse)|||Capsella bursa-pastoris [Shepherd purse]|||roots, shepherd's purse, Capsella bursa-pastoris|||Capsella bursa-pastoris (shepherd's purse)|||roots, shepherd's purse, Capsella bursa-pastoris Rich N/A "Plant Mol Biol . 2000 Sep;44(2):187-97. doi: 10.1023/a:1006431320677.||Remuzgo et al., 2014|||11117262|||Plant Mol Biol. 2000 Sep;44(2):187-197.|||11117262|||Plant Mol Biol. 2000 Sep;44(2):187-97. Pub-Med.||Remuzgo et al., 2014|||Plant Mol Biol. 2000 Sep;44(2):187-197.|||Plant Mol Biol. 2000 Sep;44(2):187-97. Pub-Med." 28 FPDB01876 AP00514|||Ranalexin-1Ca|||DRAMP01356|||Ranalexin-1Ca|||AP00514|||DRAMP01356|||AP00514 FLGGLMKAFPALICAVTKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial ; Rana clamitans [Green frog]||Anti-S.aureus, activity value is MIC = 17 uM||Anti-E.coli, activity value is MIC = 4 uM||Anti-C.albicans, activity value is MIC = 14 uM||Anti-Staphylococcus aureus, activity value is MIC = 17 uM||Anti-Escherichia coli, activity value is MIC = 4 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- North American green frog Rana clamitans|||Rana clamitans [Green frog]|||Rana clamitans (Green frog) (Lithobates clamitans)|||North American green frog Rana clamitans|||Rana clamitans (Green frog) (Lithobates clamitans)|||Bos taurus (Bovine)|||North American green frog Rana clamitans N/A S.aureus ( MIC = 17 uM), E.coli ( MIC = 4 uM), C.albicans ( MIC = 14 uM) Peptides 2000; 21:469-476|||https://pubmed.ncbi.nlm.nih.gov/10822101|||Peptides. 2000 Apr;21(4):469-476.||Ref.10822101|||10822101|||Peptides 2000; 21:469-476|||Ref.10822101|||J Proteome Res. 2008 Feb;7(2):795-802.|||Peptides 2000; 21:469-476 20 FPDB01880 AP00520|||DRAMP03578|||Histatin-3|||AP00520|||DRAMP03578 DSHAKRHHGYKRKFHEKHHSHRGYRSNYLYDN Active against C. albicans.||Antimicrobial||Antibacterial||Antifungal||Anti-34417532: Streptococcus mutans U159, activity value is MIC = 128 ug/ml||Anti-Gram+ & Gram-||candidacidal Saliva; Homo sapiens|||Homo sapiens (Human)|||Homo sapiens [Human]|||Saliva; Homo sapiens|||Homo sapiens (Human) Helix||Rich N/A J Biol Chem. 1988 Jun 5;263(16):7472-7|||J Biol Chem. 1988 Jun 5;263(16):7472-7477|||3286634, 34417532|||J Biol Chem. 1988 Jun 5;263(16):7472-7|||J Biol Chem. 1988 Jun 5;263(16):7472-7477 32 FPDB01882 AP00523|||DRAMP03583|||Human Histatin 8|||P-116|||AP00523|||DRAMP03583 KFHEKHHSHRGY Anti-Gram+ & Gram-||Antifungal||candidacidal||Antimicrobial||Antibacterial Homo sapiens|||Homo sapiens (Human)|||Homo sapiens [Human]|||Homo sapiens|||Homo sapiens (Human) Rich N/A Arch Oral Biol 2003 May;48(5):361-8|||Arch Oral Biol 2003 May;48(5):361-368.|||12711380|||11302797|||Arch Oral Biol 2003 May;48(5):361-8|||Arch Oral Biol 2003 May;48(5):361-368. 12 FPDB01883 AP00525|||Maximin H2|||DRAMP01124|||Maximin H2|||AP00525|||DRAMP01124|||AP00525 ILGPVLSMVGSALGGLIKKI Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial ; Bombina maxima [Giant fire-bellied toad]||Anti-Escherichia coli ATCC25922, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 2 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 4 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 1010, activity value is MIC = 4 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 2 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- Chinese red belly toad Bombina maxima, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Chinese red belly toad Bombina maxima, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Chinese red belly toad Bombina maxima, Asia N/A "The document does not mention content related to 'hemolytic values,' but it does mention the results of hemolysis experiments: - Maximin H peptide: At a concentration of 50 μg/ml, it can cause 90-100% hemolysis of rabbit red blood cells, showing strong hemolytic activity. - Maximin 1-5: Even at a concentration as high as 50 μg/ml, its hemolytic activity on red blood cells is very low.|||Escherichia coli ATCC25922 ( MIC = 20 ug/ml ), Staphylococcus aureus ATCC2592 ( MIC = 2 ug/ml ), Bacillus pyocyaneus CMCCB1010 ( MIC = 4 ug/ml ), Candida albicans ATCC2002 ( MIC = 2 ug/ml )|||The hemolysis rate ranges from 90% to 100% at a concentration of 50 ug/ml." "Peptides . 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides. 2002 Mar;23(3):427-35. PubMed.|||Eur J Biochem. 2000 Feb;267(3):894-900.|||Peptides. 2002 Mar;23(3):427-35. PubMed." 20 FPDB01884 AP00526|||Maximin H3|||DRAMP01125|||Maximin H3|||AP00526|||DRAMP01125|||AP00526 ILGPVLGLVGNALGGLIKKI Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial ; Bombina maxima [Giant fire-bellied toad]||Anti-Escherichia coli ATCC25922, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 10 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 20 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 10 ug/ml||Anti-Bacillus pyocyaneus CMCCB 1010, activity value is MIC = 20 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 5 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- Chinese red belly toad Bombina maxima, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Chinese red belly toad Bombina maxima, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Chinese red belly toad Bombina maxima, Asia N/A "The document does not mention content related to 'hemolytic values,' but it does mention the results of hemolysis experiments: - Maximin H peptide: At a concentration of 50 μg/ml, it can cause 90-100% hemolysis of rabbit red blood cells, showing strong hemolytic activity. - Maximin 1-5: Even at a high concentration of 51 μg/ml, its hemolytic activity toward red blood cells is very low.|||Escherichia coli ATCC25922 ( MIC = 20 ug/ml ), Staphylococcus aureus ATCC2592 ( MIC = 10 ug/ml ), Bacillus pyocyaneus CMCCB1010 ( MIC = 20 ug/ml ), Candida albicans ATCC2002 ( MIC = 5 ug/ml )|||The hemolysis rate ranges from 90% to 100% at a concentration of 50 ug/ml." "Peptides . 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides. 2002 Mar;23(3):427-35. PubMed.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||Peptides. 2002 Mar;23(3):427-35. PubMed." 20 FPDB01885 AP00527|||Maximin H4|||DRAMP01126|||Maximin H4|||AP00527|||DRAMP01126|||AP00527 ILGPVISKIGGVLGGLLKNL Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial ; Bombina maxima [Giant fire-bellied toad]||Anti-Escherichia coli ATCC25922, activity value is MIC = 12 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 6 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 12 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 12 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 1010, activity value is MIC = 12 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- Chinese red belly toad Bombina maxima, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Chinese red belly toad Bombina maxima, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Chinese red belly toad Bombina maxima, Asia N/A "The document does not mention content related to 'hemolytic values,' but it does mention the results of hemolysis experiments: - Maximin H peptide: At a concentration of 50 μg/ml, it can cause 90-100% hemolysis of rabbit red blood cells, showing strong hemolytic activity. - Maximin 1-5: Even at a concentration as high as 52 μg/ml, its hemolytic activity on red blood cells is very low.|||Escherichia coli ATCC25922 ( MIC = 12 ug/ml), Staphylococcus aureus ATCC2592 ( MIC = 6 ug/ml), Bacillus pyocyaneus CMCCB1010 ( MIC = 12 ug/ml), Candida albicans ATCC2002 ( MIC = 6 ug/ml)|||The hemolysis rate ranges from 90% to 100% at a concentration of 50 ug/ml." "Peptides . 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides. 2002 Mar;23(3):427-35. PubMed.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||Peptides. 2002 Mar;23(3):427-35. PubMed." 20 FPDB01913 AP00567|||CAMPSQ774|||DRAMP01251|||Dybowskin-4|||AP00567|||DRAMP01251|||AP00567 VWPLGLVICKALKIC Anti-M. luteus, activity value is MIC = 0.9 uM||Anti-M. luteus, activity value is MIC = 1.56 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3.13 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 6.25 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 30 ug/ml||Anti-Escherichia coli, activity value is MIC = 15 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 15 ug/ml||Anti-Candida albicans, activity value is MIC = 25 ug/ml||Anti-Micrococcus luteus ATCC4698, activity value is MIC = 1.56 ug/ml||Anti-Staphylococcus aureus KCTC3881, activity value is MIC = 3.13 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus epidermidis ATCC12228, activity value is MIC = 6.25 ug/ml||Anti-Shigella dysenteriae ATCC9752, activity value is MIC = 30 ug/ml||Anti-Escherichia coli KCTC2433, activity value is MIC = 15 ug/ml||Anti-Klebsiella pneumoniae ATCC10031, activity value is MIC = 15 ug/ml||Anti-Candida albicans ATCC36232, activity value is MIC = 25 ug/ml||Antibacterial||Antifungal||Anti-S. aureus, activity value is MIC = 1.9 uM||Anti-B. subtilis, activity value is MIC = 3.8 uM||Anti-S. epidermidis, activity value is MIC = 3.8 uM||Anti-S. dysenteriae, activity value is MIC = 18.1 uM||Anti-E. coli, activity value is MIC = 9.1 uM||Anti-K. pneumoniae, activity value is MIC = 9.1 uM||Anti-P.mirabilis, activity value is MIC > 100 ug/ml||Anti-P.aeruginosa, activity value is MIC > 100 ug/ml||Anti-and C. albicans, activity value is MIC = 25 ug/ml||Anti-Gram+ & Gram-||candidacidal||Hemolytic Rana dybowskii , Asia|||Rana dybowskii [Dybovsky frog]|||Rana dybowskii (Korea brown frog)|||Rana dybowskii [Dybovsky frog]|||Rana dybowskii , Asia|||Rana dybowskii (Korea brown frog)|||Rana dybowskii , Asia N/A "The document mentions hemolysis-related content. The specific hemolysis values are as follows: - Dybowskin-1: Hemolysis rate is 0.99%. - Dybowskin-2: Hemolysis rate is 10.99%. - Dybowskin-3: Hemolysis rate is 1.86%. - Dybowskin-4: Hemolysis rate is 47.58%. - Dybowskin-5: Hemolysis rate is 17.84%. - Dybowskin-6: Hemolysis rate is 59.42%.|||hRBC (47.58% hemolysis at 100 ug/ml)|||At a concentration of 100 ug/ml, the hemolysis rate of Dybowskin-1 was 0.99%,Dybowskin-2 10.99%,Dybowskin-3 1.86%,Dybowskin-4 47.58%,Dybowskin-5 17.84%,Dybowskin-6 59.39%.|||[Ref:17698251] It has 47.58% hemolytic activity at 100 ug/ml against human red blood cells|||hRBC (47.58% hemolysis at 100 ug/ml)|||At the test concentration of 100 ug/ml, the hemolysis rate of Dybowskin-4 on human red blood cells is only 47.58%.|||[Ref:17698251] It has 47.58% hemolytic activity at 100 ug/ml against human red blood cells" "Peptides . 2007 Aug;28(8):1532-9. doi: 10.1016/j.peptides.2007.07.002. Epub 2007 Jul 7.|||17698251|||Peptides 2007; 28: 1532-1539.||Ref.17698251|||17698251||Ref.17698251|||17698251|||Peptides 2007; 28: 1532-1539. PubMed.|||Ref.17698251|||Peptides 2007; 28: 1532-1539. PubMed." 15 FPDB01914 AP00568|||DRAMP01252|||AP00568|||DRAMP01252 GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKKISGGC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Micrococcus luteus ATCC4698, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus KCTC3881, activity value is MIC = 25 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 50 ug/ml||Anti-Staphylococcus epidermidis ATCC12228, activity value is MIC = 50 ug/ml||Anti-Shigella dysenteriae ATCC9752, activity value is MIC = 50 ug/ml||Anti-Escherichia coli KCTC2433, activity value is MIC = 60 ug/ml||Anti-Klebsiella pneumoniae ATCC10031, activity value is MIC = 50 ug/ml||Anti-Candida albicans ATCC36232, activity value is MIC = 50 ug/ml||Anti-M. luteus, activity value is MIC = 1.8 uM||Anti-S. aureus, activity value is MIC = 6.8 uM||Anti-B. subtilis, activity value is MIC = 13.6 uM||Anti-S. epidermidis, activity value is MIC = 13.6 uM||Anti-S. dysenteriae, activity value is MIC = 13.6 uM||Anti-E. coli, activity value is MIC = 16.8 uM||Anti-K. pneumoniae, activity value is MIC = 13.6 uM||Anti-P.mirabilis, activity value is MIC > 100 ug/ml||Anti-P.aeruginosa, activity value is MIC > 100 ug/ml||Anti-and C. albicans, activity value is MIC = 13.6 ug/ml Rana dybowskii , Asia|||Rana dybowskii (Korea brown frog)|||Rana dybowskii , Asia|||Rana dybowskii (Korea brown frog) N/A "The document mentions content related to hemolysis. The specific hemolysis values are as follows: - Dybowskin-1: Hemolysis rate is 0.99%. - Dybowskin-2: Hemolysis rate is 10.99%. - Dybowskin-3: Hemolysis rate is 1.86%. - Dybowskin-4: Hemolysis rate is 47.58%. - Dybowskin-5: Hemolysis rate is 17.84%. - Dybowskin-6: Hemolysis rate is 59.43%.|||At a concentration of 100 ug/ml, the hemolysis rate of Dybowskin-1 was 0.99%,Dybowskin-2 10.99%,Dybowskin-3 1.86%,Dybowskin-4 47.58%,Dybowskin-5 17.84%,Dybowskin-6 59.39%.|||[Ref:17698251] It has 17.84% hemolytic activity at 100 ug/ml against human red blood cells|||At the test concentration of 100 ug/ml, the hemolysis rate of Dybowskin-5 on human red blood cells is 17.84%.|||[Ref:17698251] It has 17.84% hemolytic activity at 100 ug/ml against human red blood cells" "Peptides . 2007 Aug;28(8):1532-9. doi: 10.1016/j.peptides.2007.07.002. Epub 2007 Jul 7.|||Peptides 2007; 28: 1532-1539.||Ref.17698251|||17698251||Ref.17698251|||Peptides 2007; 28: 1532-1539. PubMed.|||Ref.17698251|||Peptides 2007; 28: 1532-1539. PubMed." 38 FPDB01915 AP00569|||Dybowskin-6|||DRAMP01253|||Dybowskin-6|||AP00569|||DRAMP01253|||AP00569 FLPLLLAGLPLKLCFLFKKC Anti-Gram+||Antifungal||candidacidal||Hemolytic||Antibacterial ; Synthetic construct||Anti-M. luteus, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 50 ug/ml||Anti-Candida albicans, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus ATCC4698, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus KCTC3881, activity value is MIC = 12.5 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 50 ug/ml||Anti-Staphylococcus epidermidis ATCC12228, activity value is MIC = 50 ug/ml Rana dybowskii , Asia|||Synthetic construct|||Rana dybowskii (Korea brown frog)|||Rana dybowskii , Asia|||Rana dybowskii (Korea brown frog)|||Rana dybowskii , Asia N/A "The document mentions content related to hemolysis. The specific hemolysis values are as follows: - Dybowskin-1: Hemolysis rate is 0.99%. - Dybowskin-2: Hemolysis rate is 10.99%. - Dybowskin-3: Hemolysis rate is 1.86%. - Dybowskin-4: Hemolysis rate is 47.58%. - Dybowskin-5: Hemolysis rate is 17.84%. - Dybowskin-6: Hemolysis rate is 59.44%.|||M. luteus ( MIC = 6.25 ug/ml ), Staphylococcus aureus ( MIC = 12.5 ug/ml ), Bacillus subtilis ( MIC = 6.25 ug/ml ), Staphylococcus epidermidis ( MIC = 50 ug/ml ), Shigella dysenteriae ( MIC = 50 ug/ml ), Escherichia coli ( MIC = >100 ug/ml ), Klebsiella pneumoniae ( MIC = >100 ug/ml ), Proteus mirabilis ( MIC = >100 ug/ml ), Pseudomonas aeruginosa ( MIC = >100 ug/ml ), Candida albicans ( MIC = 50 ug/ml )|||At a concentration of 100 ug/ml, the hemolysis rate of Dybowskin-1 was 0.99%,Dybowskin-2 10.99%,Dybowskin-3 1.86%,Dybowskin-4 47.58%,Dybowskin-5 17.84%,Dybowskin-6 59.39%.|||[Ref:17698251] It has 59.39% hemolytic activity at 100 ug/ml against huamn red blood cells|||hRBC (59.39% hemolysis at 100 ug/ml)|||At the test concentration of 100 ug/ml, the hemolysis rate of Dybowskin-6 on human red blood cells is only 59.39%.|||[Ref:17698251] It has 59.39% hemolytic activity at 100 ug/ml against huamn red blood cells" "Peptides . 2007 Aug;28(8):1532-9. doi: 10.1016/j.peptides.2007.07.002. Epub 2007 Jul 7.|||https://pubmed.ncbi.nlm.nih.gov/17698251|||Peptides 2007; 28: 1532-1539.|||17698251|||Peptides 2007; 28: 1532-1539. PubMed.|||Peptides 2007; 28: 1532-1539. PubMed." 20 FPDB01916 AP00570|||Pleurain-a1|||DRAMP01208|||DRAMP01209|||Pleurain-a1|||AP00570|||DRAMP01208|||AP00570 SIITMTKEAKLPQLWKQIACRLYNTC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antioxidant||Anti-Escherichia coli ATCC 25922, activity value is MIC = 60 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 120 ug/ml||Anti-Helicobacter pylori NCTC 11637, activity value is MIC = 30 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 15 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 30 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 15 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 60 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 60 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 15 ug/ml||Anti-B.subtilis ATCC 6633, activity value is MIC = 120 ug/ml||Anti-H. pylori NCTC11637, activity value is MIC = 30 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 30 ug/ml skin secretions, Rana pleuraden, China, Asia|||Rana pleuraden [Yunnan pond frog]|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden [Yunnan pond frog]|||skin secretions, Rana pleuraden, China, Asia|||Rana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A Rabbit erythrocytes ( 200 ug/ml )|||[Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 ug/ml|||Rabbit erythrocytes ( 200 ug/ml )|||At concentrations as high as 200 ug/ml, the hemolysis rate is close to 0%.|||[Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 ug/ml "Peptides . 2007 Oct;28(10):2069-74. doi: 10.1016/j.peptides.2007.07.020. Epub 2007 Jul 22.|||17764786, 19028675|||Peptides. 2007 Oct;28(10):2069-2074.||Ref.17764786|||17764786||Ref.17764786|||17764786, 19028675|||Peptides 2007; 28: 2069-2074. PubMed.|||Ref.17764786|||Peptides 2007; 28: 2069-2074. PubMed." 26 FPDB01917 AP00571|||Pleurain-a2|||DRAMP01209|||Pleurain-a2|||AP00571|||DRAMP01209|||AP00571 SIITMTKEAKLPQSWKQIACRLYNTC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 60 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 60 ug/ml||Anti-Helicobacter pylori NCTC 11637, activity value is MIC = 30 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 15 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 30 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 60 ug/ml||Anti-B. dysenteriae, activity value is MIC = 60 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 15 ug/ml||Anti-H. pylori NCTC11637, activity value is MIC = 30 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 30 ug/ml Rana pleuraden, Asia|||Rana pleuraden [Yunnan pond frog]|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden [Yunnan pond frog]|||Rana pleuraden, Asia|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden, Asia N/A little hemolytic activity ( 200 ug/ml)|||[Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 ug/ml|||little hemolytic activity ( 200 ug/ml)|||[Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 ug/ml "Peptides . 2007 Oct;28(10):2069-74. doi: 10.1016/j.peptides.2007.07.020. Epub 2007 Jul 22.|||17764786|||17764786||Ref.17764786|||17764786|||Peptides 2007; 28: 2069-2074. PubMed.|||Ref.17764786|||Peptides 2007; 28: 2069-2074. PubMed." 26 FPDB01923 AP00579|||Nigrocin-2GRc, Grahamin-2, Grahamin-1|||Nigrocin-2GRc, Grahamin-2, Grahamin-1|||DRAMP01417|||AP00579 GLLSGILGAGKHIVCGLSGLC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-E. coli, activity value is MIC = 50 uM||Anti-S. aureus, activity value is MIC > 100 uM||Anti-C. albicans, activity value is MIC > 100 uM Rana grahami, Also skin, Odorrana grahami, Asia|||Rana grahami [Yunnanfu frog]|||Rana grahami (Asian frog)|||Rana grahami, Also skin, Odorrana grahami, Asia N/A "The document mentions hemolytic-related content. The following are the specific hemolytic values: - Esculentin-1GRa: The concentration causing 50% hemolysis of human red blood cells (LC₅₀) is 210 μM. - Brevinin-2GRa: LC₅₀ is 140 μM. - Brevinin-2GRb: LC₅₀ is 180 μM. - Brevinin-2GRc: LC₅₀ is 100 μM. - Nigrocin-2GRa: LC₅₀ is 295 μM. - Nigrocin-2GRb: LC₅₀ is 40 μM. - Nigrocin-2GRc: LC₅₀ is greater than 505 μM.|||[Ref:16621155] LC50=295 uM against human erythrocytes" "Peptides . 2006 Sep;27(9):2111-7. doi: 10.1016/j.peptides.2006.03.002. Epub 2006 Apr 18.|||16621155 , 16487561|||16621155 , 16487561|||[Ref.16621155]Gram-negative bacterium:Escherichia coli (MIC=25 uM).|||Peptides 2006; 27: 2111-2117. PubMed." 21 FPDB01924 AP00580|||Nigrocin-2GRb|||DRAMP01418|||Nigrocin-2GRb|||AP00580|||DRAMP01418|||AP00580 GLFGKILGVGKKVLCGLSGMC Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anti-S. aureus, activity value is MIC = 12.5 uM||Anti-E. coli, activity value is MIC = 3 uM||Anti-C. albicans, activity value is MIC = 50 uM||Anti-Staphylococcus aureus, activity value is MIC = 12.5 uM||Anti-Escherichia coli, activity value is MIC = 3 uM||Anti-Candida albicans, activity value is MIC = 50||Anti-Candida albicans, activity value is MIC = 50 uM||Anti-microorganisms E. coli ATCC 25922, activity value is MIC = 3 uM||Anti-S. aureus NCTC 8325, activity value is MIC = 12.5 uM Rana grahami, Asia|||Rana grahami [Yunnanfu frog]|||Rana grahami (Asian frog)|||Rana grahami, Asia|||Rana grahami (Asian frog)|||Rana grahami, Asia N/A "The document mentions hemolytic-related content. The following are the specific hemolytic values: - Esculentin-1GRa: The concentration causing 50% hemolysis of human red blood cells (LC₅₀) is 210 μM. - Brevinin-2GRa: LC₅₀ is 140 μM. - Brevinin-2GRb: LC₅₀ is 180 μM. - Brevinin-2GRc: LC₅₀ is 100 μM. - Nigrocin-2GRa: LC₅₀ is 295 μM. - Nigrocin-2GRb: LC₅₀ is 40 μM. - Nigrocin-2GRc: LC₅₀ is greater than 506 μM.|||Hemolytic activity against human erythrocytes ( LD50 = 40 uM )|||[Ref:16621155] LC50=40 uM against human erythrocytes|||Hemolytic activity against human erythrocytes ( LD50 = 40 uM )|||LC₅₀=40 uM|||[Ref:16621155] LC50=40 uM against human erythrocytes" "Peptides . 2006 Sep;27(9):2111-7. doi: 10.1016/j.peptides.2006.03.002. Epub 2006 Apr 18.|||16621155|||Peptides. 2006 Sep;27(9):2111-2117.||Ref.16621155|||16621155||Ref.16621155|||16621155|||Peptides 2006; 27: 2111-2117. PubMed.|||[Ref.16621155]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 uM); Gram-negative bacterium: Escherichia coli (MIC=3 uM); Yeast: Candida albicans (MIC=50 uM).|||Peptides 2006; 27: 2111-2117. PubMed." 21 FPDB01925 AP00581|||Nigrosin-OG20 , nigrocin-2GRa , Grahamin-1, nigrosin-OG17, Grahamin-2|||Nigrosin-OG20 , nigrocin-2GRa , Grahamin-1, nigrosin-OG17, Grahamin-2|||DRAMP01419|||AP00581 GLLSGILGAGKNIVCGLSGLC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-S. aureus, activity value is MIC = 75 ug/ml||Anti-B. subtilis, activity value is MIC = 9.37 ug/ml||Anti-C.albicans, activity value is MIC = 9.37 ug/ml||Anti-S. aureus, activity value is MIC > 100 uM Rana grahami, Asia|||Odorrana grahami [Yunnanfu frog]|||Rana grahami (Asian frog)|||Rana grahami, Asia N/A "The document mentions hemolytic-related content. The following are the specific hemolytic values: - Esculentin-1GRa: The concentration causing 50% hemolysis of human red blood cells (LC₅₀) is 210 μM. - Brevinin-2GRa: LC₅₀ is 140 μM. - Brevinin-2GRb: LC₅₀ is 180 μM. - Brevinin-2GRc: LC₅₀ is 100 μM. - Nigrocin-2GRa: LC₅₀ is 295 μM. - Nigrocin-2GRb: LC₅₀ is 40 μM. - Nigrocin-2GRc: LC₅₀ is greater than 507 μM.|||Hemolytic activity ( LC50 = 295 uM)|||Hemolytic activity ( LC50 = 295 uM)|||[Ref:16621155] LC50>500 uM against human erythrocytes" "Peptides . 2006 Sep;27(9):2111-7. doi: 10.1016/j.peptides.2006.03.002. Epub 2006 Apr 18.|||17272268 , 16621155 , 16487561||PubMed 17272268||PubMed 16621155|||17272268 , 16621155 , 16487561||PubMed 17272268||PubMed 16621155|||[Ref.16621155]Gram-negative bacterium: Escherichia coli (MIC=50 uM).|||Peptides 2006; 27: 2111-2117. PubMed." 21 FPDB01935 AP00597|||CAMPSQ1001|||CAMPSQ4334|||DRAMP01818|||Temporin-1DRb|||AP00597|||DRAMP01818|||AP00597 NFLGTLVNLAKKIL Anti-S. aureus ATCC 25923, activity value is MIC = 16||Anti-C. albicans, activity value is MIC = 80 uM||Anti-E. coli, activity value is MIC = 64 uM||Anti-S. aureus, activity value is MIC = 16 uM||Anti-Escherichia coli, activity value is MIC = 40 uM||Anti-Staphylococcus aureus, activity value is MIC = 20 uM||Anti-Candida albicans, activity value is MIC = 80 uM||Anti-Escherichia coli, activity value is MIC = 64 uM||Anti-Staphylococcus aureus, activity value is MIC = 16 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Hemolytic North America, Rana cascadae|||Rana cascadae|||Rana draytonii [California red-legged frog]|||Rana cascadae (Cascades frog)|||Rana draytonii [California red-legged frog]|||skin secretions, Rana cascadae, North America|||Rana cascadae (Cascades frog)|||skin secretions, Rana cascadae, North America N/A "The document mentions hemolysis-related information; the specific hemolysis values are as follows: -Ranatuerin-2CSa: The concentration (LD₅₀) that causes 50% hemolysis of human red blood cells is 150 µM. -Brevinin-1CSa: LD50 is 5 µM. -Temporin-1CSa: LD50 is 75 µM. -Temporin-1CSb: LD50 is 95 µM. -Temporin-1CSd: LD50 is 52 µM.|||Human erythrocytes ( IC50 = 65 uM )|||In Document 9 (Peptides 2007), the LD₅₀ of Ranatuerin-2CSa on human red blood cells is 150 μM, the LD₅₀ of Brevinin-1CSa on human red blood cells is 5 μM, the LD₅₀ of Temporin-1CSa on human red blood cells is 75 μM, the LD₅₀ of Temporin-1CSb on human red blood cells is 95 μM, the LD₅₀ of Temporin-1CSc on human red blood cells is greater than 300 μM, and the LD₅₀ of Temporin-1CSd on human red blood cells is 50 μM.|||Human erythrocytes ( IC50 = 65 uM )|||LC₅₀=50 uM" "Peptides . 2007 Jun;28(6):1268-74. doi: 10.1016/j.peptides.2007.03.010. Epub 2007 Mar 27.|||17451843|||16307827|||Peptides 2007; 28: 1268-1274.|||17451843|||16307827|||Peptides 2007; 28: 1268-1274. PubMed.|||Peptides 2007; 28: 1268-1274. PubMed." 14 FPDB01937 AP00600|||Antimicrobial peptide odorranin-HP|||DRAMP01394|||AP00600|||DRAMP01394|||AP00600 GLLRASSVWGRKYYVDLAGCAKA Anti-H. pylori NCTC11637, activity value is MIC = 20 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 5 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 30 ug/ml||Anti-B. dysenteriae, activity value is MIC = 30 ug/ml||Antibacterial||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 30 ug/ml||Anti-Helicobacter pylori NCTC 11637, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana grahami, Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog)|||Odorrana grahami, Asia|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami, Asia N/A The document mentions that odorranain-HP, at concentrations as high as 100,000 µg/ml, has almost no hemolytic activity on rabbit red blood cells.|||Escherichia coli ATCC 25922 ( MIC = 30 ug/ml), Bacillus dysenteriae ( MIC = 30 ug/ml), Helicobacter pylori NCTC 11637 ( MIC = 20 ug/ml), Staphylococcus aureus ATCC 2592 ( MIC = 5 ug/ml), Candida albicans ATCC 2002 ( MIC = 25 ug/ml)|||MiAMP1, at a concentration of 100 µg/ml, has no hemolytic effect on human red blood cells, and no red blood cell lysis was observed. Peptides 2007; 28: 1527-1531|||17698252|||Peptides. 2007 Aug;28(8):1527-1531|||17698252|||Peptides 2007; 28: 1527-1531|||Peptides 2007; 28: 1527-1531 23 FPDB01953 AP00625|||Human KR-20|||KR-20|||DRAMP03567|||Human KR-20|||KR-20|||AP00625|||AP00625 KRIVQRIKDFLRNLVPRTES : Active against S. aureus mprF (KO) (diffusion assays)||C. albicans. It also reduced the viability of T. vaginalis on a 5-nitroimidazole-sensitive and a 5-nitroimidazole-resistant strain .||Antibacterial||Antifungal ; Homo sapiens [Human]||Antifungal||Anti-S. aureus mprF, activity value is MIC = 16 uM||Anti-S. aureus ATCC 25923, activity value is MIC > 64 uM||Anti-E. coli O29, activity value is MIC > 64 uM||Anti-C. albicans ATCC 14053, activity value is MIC = 10 uM||Anti-Staphylococcus aureus mprF, activity value is MIC = 16 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 64 uM||Anti-Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Escherichia coli O29, activity value is MIC > 64 uM||Antifungal ; Staphylococcus aureus mprF||Staphylococcus aureus ATCC 25923||Escherichia coli O29||Candida albicans ATCC 14053||Active against S. aureus mprF (KO) (diffusion assays)||Anti-Gram+ & Gram-||candidacidal||Antiparasitic protease truncation; human sweat, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human sweat)|||protease truncation; human sweat, Homo sapiens|||protease truncation; human sweat, Homo sapiens Alpha helix "The document mentions hemolysis-related content. The specific hemolysis values are as follows: - LL-37: At a concentration of 100 μM, the hemolysis rate is 9%. - RK-31: At a concentration of 44 μM, the hemolysis rate is 6%. - KS-30: At a concentration of 88 μM, the hemolysis rate is 2.3%. - KR-20: At a concentration of 100 μM, there is no hemolytic activity.|||Human RBC(0% hemolysis at 100 uM)|||Human erythrocytes|||Human RBC(0% hemolysis at 100 uM)" "J Immunol . 2004 Mar 1;172(5):3070-7. doi: 10.4049/jimmunol.172.5.3070.||Ramírez-Ledesma et al., 2022|||https://pubmed.ncbi.nlm.nih.gov/14978112|||14978112|||J Immunol 2004; 172: 3070-3077.|||14978112|||J Immunol 2004; 172: 3070-3077. PubMed.||Ramírez-Ledesma et al., 2022|||J Immunol 2004; 172: 3070-3077. PubMed." 20 FPDB01954 AP00626|||Human KS-30|||KS-30|||DRAMP03569|||Human KS-30|||KS-30|||AP00626|||AP00626 KSKEKIGKEFKRIVQRIKDFLRNLVPRTES Active against C. albicans and susceptible strain S. aureus mprF (KO).||Staphylococcus aureus mprF||Staphylococcus aureus ATCC 25923||Escherichia coli O29||Candida albicans ATCC 14054||Anti-S. aureus mprF, activity value is MIC = 8 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 16 uM||Anti-E. coli O29, activity value is MIC = 8 uM||Anti-C. albicans ATCC 14053, activity value is MIC = 2 uM||Anti-Staphylococcus aureus mprF, activity value is MIC = 8 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 16 uM||Anti-Group A Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Escherichia coli O29, activity value is MIC = 8 uM||Anti-Candida albicans ATCC 14053, activity value is MIC = 2 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal protease truncation; human sweat, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human sweat)|||Homo sapiens [Human]|||protease truncation; human sweat, Homo sapiens|||protease truncation; human sweat, Homo sapiens Alpha helix "The document mentions hemolysis-related content. The specific hemolysis values are as follows: - LL-37: At a concentration of 100 μM, the hemolysis rate is 9%. - RK-31: At a concentration of 44 μM, the hemolysis rate is 6%. - KS-30: At a concentration of 88 μM, the hemolysis rate is 2.3%. - KR-20: At a concentration of 101 μM, there is no hemolytic activity.|||Human erythrocytes|||Hemolytic activity (0.23% hemolysis at 88 uM)|||Human erythrocytes|||Hemolytic activity (0.23% hemolysis at 88 uM)" "J Immunol . 2004 Mar 1;172(5):3070-7. doi: 10.4049/jimmunol.172.5.3070.|||14978112|||J Immunol 2004; 172: 3070-3077.||Ref.14978112|||14978112|||J Immunol 2004; 172: 3070-3077. PubMed.|||J Immunol 2004; 172: 3070-3077. PubMed." 30 FPDB01955 AP00627|||RK-31|||DRAMP03568|||Human RK-31|||RK-31|||AP00627|||AP00627 RKSKEKIGKEFKRIVQRIKDFLRNLVPRTES Active against C. albicans. Structure is predicted to be helical based on NMR studies of intact LL-37 and its fragments in micelles.||Antibacterial||Antifungal||Anti-Staphylococcus aureus mprF, activity value is MIC = 8 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 16 uM||Anti-Group A Staphylococcus aureus, activity value is MIC = 8 uM||Anti-Escherichia coli O29, activity value is MIC = 8 uM||Anti-Candida albicans ATCC 14053, activity value is MIC = 4 uM||Anti-S. aureus mprF, activity value is MIC = 8 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 16 uM||Anti-E. coli O29, activity value is MIC = 8 uM||Anti-C. albicans ATCC 14053, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||candidacidal||Hemolytic protease truncation; human sweat, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human sweat)|||Homo sapiens [Human]|||protease truncation; human sweat, Homo sapiens|||protease truncation; human sweat, Homo sapiens Alpha helix "The document mentioned hemolysis-related content. The specific hemolysis values are as follows: - LL-37: At a concentration of 100 μM, the hemolysis rate is 9%. - RK-31: At a concentration of 44 μM, the hemolysis rate is 6%. - KS-30: At a concentration of 88 μM, the hemolysis rate is 2.3%. - KR-20: At a concentration of 102 μM, there is no hemolytic activity.|||Human RBC (6% hemolysis at 44 uM)|||Human erythrocytes|||Human RBC (6% hemolysis at 44 uM)" "J Immunol . 2004 Mar 1;172(5):3070-7. doi: 10.4049/jimmunol.172.5.3070|||14978112|||J Immunol 2004; 172: 3070-3077.||Ref.14978112|||14978112|||J Immunol 2004; 172: 3070-3077. PubMed.|||J Immunol 2004; 172: 3070-3077. PubMed." 31 FPDB01971 AP00647|||Brevinin-1PLb|||DRAMP01918|||Brevinin-1PLb|||AP00647|||AP00647 FLPLIAGLAANFLPKIFCAITKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 9 uM||Anti-Escherichia coli, activity value is MIC = 26 uM||Anti-Candida albicans, activity value is MIC = 6 uM pickerel frog, Rana palustris, North America|||Rana palustris [Pickerel frog]|||Rana grahami (Asian frog)|||Rana palustris (Pickerel frog)|||Rana palustris [Pickerel frog]|||pickerel frog, Rana palustris, North America|||pickerel frog, Rana palustris, North America N/A Escherichia coli ( MIC = 26 uM ), Staphylococcus aureus ( MIC = 9 uM ), Candida albicans ( MIC = 6 uM ) "Biochim Biophys Acta . 2000 Nov 30;1543(1):95-105. doi: 10.1016/s0167-4838(00)00191-6.|||11087945|||Peptides. 2007 Aug;28(8):1605-1610.|||17698247|||11087945|||Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. PubMed.|||Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. PubMed." 24 FPDB01972 AP00648|||Brevinin-1PLc|||DRAMP01919|||Brevinin-1PLc|||AP00648|||AP00648 FLPVIAGVAAKFLPKIFCAITKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Escherichia coli, activity value is MIC = 7 uM||Anti-Candida albicans, activity value is MIC = 8 uM pickerel frog, Rana palustris, North America|||Rana palustris [Pickerel frog]|||Rana grahami (Asian frog)|||Rana palustris (Pickerel frog)|||Rana palustris [Pickerel frog]|||pickerel frog, Rana palustris, North America|||pickerel frog, Rana palustris, North America N/A Escherichia coli ( MIC = 7 uM ), Staphylococcus aureus ( MIC = 4 uM ), Candida albicans ( MIC = 8 uM ) "Biochim Biophys Acta . 2000 Nov 30;1543(1):95-105. doi: 10.1016/s0167-4838(00)00191-6.|||17698247, 11087945|||Peptides. 2007 Aug;28(8):1605-1610.|||17698247|||17698247, 11087945|||Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. PubMed.|||Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. PubMed." 24 FPDB01975 AP00651|||Esculentin-2PLa|||DRAMP01456|||Esculentin-2PLa|||AP00651|||DRAMP01456|||AP00651 GLFSILKGVGKIALKGLAKNMGKMGLDLVSCKISKEC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Escherichia coli, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 10 uM||Anti-Candida albicans, activity value is MIC = 49 uM pickerel frog, Rana palustris, North America|||Rana palustris [Pickerel frog]|||Rana palustris (Pickerel frog)|||Rana palustris [Pickerel frog]|||pickerel frog, Rana palustris, North America|||Rana palustris (Pickerel frog)|||pickerel frog, Rana palustris, North America N/A N/A "Biochim Biophys Acta . 2000 Nov 30;1543(1):95-105. doi: 10.1016/s0167-4838(00)00191-6.|||11087945|||Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.|||11087945|||Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. PubMed.|||Gram-negative bacterium: Escherichia coli (MIC=1 uM); Gram-positive bacterium: Staphylococcus aureus (MIC=10 uM). Yeast: Candida albicans (MIC=49 uM).|||Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. PubMed." 37 FPDB01984 AP00660|||Pandinin-2|||AP00660 FWGALAKGALKLIPSLFSSFSKKD Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Antibacterial venom, Pandinus imperator|||Pandinus imperator [Emperor scorpion]|||venom, Pandinus imperator, West Africa Helix P.aeruginosa ( MIC = 38.2 uM ), E. coli ( MIC = 19.1 uM ), E. faecalis ( MIC = 2.4 uM ), C. albicans ( MIC = 19.1 uM ), B. subtilis ( MIC = 4.8 uM ), S. epidermidis ( MIC = 4.8 uM ), S. aureus ( MIC = 2.4 uM ) "Biochem J . 2001 Oct 1;359(Pt 1):35-45. doi: 10.1042/0264-6021:3590035.|||11563967|||Biochem J. 2001 Oct 1;359(Pt 1):35-45. PubMed" 24 FPDB01985 AP00661|||DRAMP01518|||Esculentin-2000 ml|||AP00661|||DRAMP01518 GILSLFTGGIKALGKTLFKMAGKAGAEHLACKATNQC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Escherichia coli, activity value is MIC = 6 uM||Antibacterial North America, Rana luteiventris|||Rana luteiventris (Great Basin spotted frog)|||Rana luteiventris [Spotted frog]|||North America, Rana luteiventris|||Rana luteiventris (Great Basin spotted frog) N/A N/A "Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||10651828||Ref.10651828|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed.|||Ref.10651828|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed." 37 FPDB01986 AP00662|||DRAMP01516|||Esculentin-2B|||AP00662|||DRAMP01516 GLFSILRGAAKFASKGLGKDLTKLGVDLVACKISKQC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Staphylococcus aureus, activity value is MIC = 1 uM||Anti-Escherichia coli, activity value is MIC = 1 uM||Antibacterial North America, Rana berlandieri|||Rana luteiventris (Great Basin spotted frog)|||Rana berlandieri (Rio Grande leopard frog)|||Rana berlandieri [Rio Grande leopard frog]|||North America, Rana berlandieri|||Rana berlandieri (Rio Grande leopard frog) N/A N/A "Eur J Biochem . 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Eur J Biochem. 2000 Feb;267(3):894-900.||Ref.10651828|||10651828||Ref.10651828|||10651828|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed.|||Ref.10651828|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed." 37 FPDB02000 AP00694|||Prepromelittin-related peptide|||DRAMP01347|||Prepromelittin-related peptide|||AP00694|||DRAMP01347|||AP00694 AIGSILGALAKGLPTLISWIKNR Anti-S. aureus, activity value is MIC = 3.5 uM||Anti-E. coli, activity value is MIC = 20 uM||Anti-and C. albicans, activity value is MIC = 19 uM||Antibacterial||Antifungal||Anticancer||Antiviral||Anti-Staphylococcus aureus, activity value is MIC = 3.5 uM||Anti-Escherichia coli, activity value is MIC = 20 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 3.13 uM||Anti-Bacillus subtilis, activity value is MIC = 3.13 uM||Anti-Escherichia coli, activity value is MIC = 25 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 12.5 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 12.5 uM||Anti-S. aureus, activity value is MIC = 3||Anti-C. albicans, activity value is MIC = 19 uM||Anti-EL4 T-lymphoma cells, activity value is MIC = 14 uM||Anti-E. coli, activity value is MIC = 20||Anti-K. pneumoniae ATCC 10031, activity value is MIC = 6.25 uM||Anti-Gram+ & Gram-||candidacidal||Enzyme inhibitor||Hemolytic Rana tagoi, Asia|||Rana tagoi [Tago frog]|||Rana tagoi (Tago frog)|||Rana tagoi, Asia|||Rana tagoi (Tago frog)|||Rana tagoi, Asia Alpha helix||Helix "The document mentions that the half-hemolytic concentration (HC₅₀) of melittin on human red blood cells is 0.6 μM, while the HC₅₀ of melittin-related peptide (MRP) extracted from the skin of Japanese frogs is 8 μM. This indicates that the hemolytic activity of MRP is 13 times lower than that of melittin.|||Human erythrocytes (8 uM), L929 fibroblasts (20 uM)|||[Ref.27271216] 100% hemolysis at 20 uM against human red blood cells|||Human erythrocytes (8 uM), L929 fibroblasts (20 uM)|||[Ref.27271216] 100% hemolysis at 20 uM against human red blood cells|||The hemolytic values mentioned in the document are as follows: - Melittin-Related Peptide (MRP): the half-maximal hemolytic concentration (HC_{50}) on human red blood cells is 8 µM. - Melittin: the half-maximal hemolytic concentration (HC_{50}) on human red blood cells is 0.6 µM. These two values indicate that the hemolytic activity of MRP is significantly lower than that of melittin (approximately 13 times lower).|||Human erythrocytes (8 uM), L929 fibroblasts (20 uM)" "Biochem Biophys Res Commun . 2003 Jun 27;306(2):496-500. doi: 10.1016/s0006-291x(03)00999-9.|||12804591, 35055066|||12804591||Ref.12804591||Ref.27271216|||12804591, 35055066||Refer Pubmed ID 12804591||Refer Pubmed ID 35055066|||Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500. PubMed|||Ref.12804591||Ref.27271216|||Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500. PubMed|||12804591, 35055066||Refer Pubmed ID 12804591||Refer Pubmed ID 35055066|||Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500. PubMed" 23 FPDB02027 AP00752|||DRAMP03527|||AP00752 DKLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFWNVNCWCEE Anti-Gram+||Antifungal||candidacidal||Anti-Sarcina Lutea, activity value is MIC = 1.9 uM||Anti-Candida albicans, activity value is MIC = 2.9 uM||Anti-C. fructus, activity value is MIC = 2.9 uM||Anti-Candida wickerhamii, activity value is MIC = 2.9 uM||Anti-Pichia pastoris, activity value is MIC = 2.9 uM||Anti-P. stiptis, activity value is MIC = 2.9 uM||Anti-Pachysolen tannophilus, activity value is MIC = 2.9 uM||Anti-Trichoderma harzianum, activity value is MIC = 2.9 uM||Anti-Zygosaccharomyces marxianus, activity value is MIC = 2.9 uM wax moth, Galleria mellonella|||Galleria mellonella (Greater wax moth)|||wax moth, Galleria mellonella Bridge N/A 2007 Mar;28(3):533-46. doi: 10.1016/j.peptides.2006.11.010. Epub 2006 Dec 27.|||Peptides. 2007 Mar;28(3):533-546.|||Peptides 2007; 28: 533-546. PubMed|||Peptides 2007; 28: 533-546. PubMed 44 FPDB02049 AP00777|||Winter flounder 1|||DRAMP02347|||Winter flounder 1|||AP00777|||AP00777 GKGRWLERIGKAGGIIIGGALDHL Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Aeromonas salmonicida 99-1, activity value is MIC = 64 ug/ml||Anti-Aeromonas salmonicida 97-4, activity value is MIC = 64 ug/ml||Anti-Salmonella enterica serovar Typhimurium MS7953s, activity value is MIC = 16 ug/ml||Anti-Salmonella enterica serovar Typhimurium 14028s, activity value is MIC > 64 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC > 64 ug/ml||Anti-Pseudomonas aeruginosa Z61, activity value is MIC = 32 ug/ml||Anti-Escherichia coli CGSC 4908, activity value is MIC = 32 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 32 ug/ml||Anti-Escherichia coli DC2, activity value is MIC = 32 ug/ml||Anti-Staphylococcus epidermidis C621, activity value is MIC > 64 ug/ml||Anti-Staphylococcus aureus C623, activity value is MIC > 64 ug/ml||Anti-A. salmonicida 99-1, activity value is MIC = 64 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 64 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 32 ug/ml||Anti-E. coli CGSC 4908, activity value is MIC = 32 ug/ml||Anti-E. coli UB1005, activity value is MIC = 32 ug/ml||Anti-E. coli DC2, activity value is MIC = 32 ug/ml||Anti-C. albicans C627, activity value is MIC = 64 ug/ml winter flounder 1, Pleuronectes americanus|||Pseudopleuronectes americanus [Winter flounder]|||Pseudopleuronectes americanus (Winter flounder 1)|||Pseudopleuronectes americanus [Winter flounder]|||winter flounder 1, Pleuronectes americanus|||winter flounder 1, Pleuronectes americanus N/A A. salmonicida 99-1 (MIC = 64 ug/ml), A. salmonicida 97-4 (MIC = 64 ug/ml), S. enterica serovar Typhimurium MS7953s (MIC = 16 ug/ml), S. enterica serovar Typhimurium 14028s (MIC = >64 ug/ml), P. aeruginosa K799 (MIC = >64 ug/ml), P. aeruginosa Z61 (MIC = 32 ug/ml), E. coli CGSC 4908 (MIC = 32 ug/ml), E. coli UB1005 (MIC = 32 ug/ml), E. coli DC2 (MIC = 32 ug/ml), S. epidermidis C621 (MIC = >64 ug/ml), MRSA C623 (MIC = >64 ug/ml), C. albicans C627 (MIC = 64 ug/ml)|||In Document 1 (ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2003), the specific hemolytic values of the 20 cationic antimicrobial peptides (NRC-1 to NRC-20) derived from flounder genes were not explicitly mentioned. 2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.|||12878506|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed. 24 FPDB02051 AP00785|||NRC-11|||NRC-11|||AP00785|||AP00785 GWKSVFRKAKKVGKTVGGLALDHYL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-A. salmonicida 99-1, activity value is MIC = 8 ug/ml||Anti-A. salmonicida 97-4, activity value is MIC = 8 ug/ml||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 4 ug/ml||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa K799, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 4 ug/ml||Anti-E. coli CGSC4908, activity value is MIC = 4 ug/ml||Anti-E. coli UB1005, activity value is MIC = 16 ug/ml||Anti-E. coli DC2, activity value is MIC = 4 ug/ml||Anti-S. epidermidis C621, activity value is MIC = 64 ug/ml||Anti-C. albicans C627, activity value is MIC = 32 ug/ml||Anti-A. salmonicida 99-1, activity value is MIC = 8 uM||Anti-A. salmonicida 97-4, activity value is MIC = 8 uM||Anti-S. enterica serovar Typhimurium MS7953s, activity value is MIC = 4 uM||Anti-S. enterica serovar Typhimurium 14028s, activity value is MIC = 32 uM||Anti-P. aeruginosa K799 or Z61, activity value is MIC = 4||Anti-E. coli CGSC4908 or UB1005 or DC2, activity value is MIC = 4||Anti-S. epidermidis C621, activity value is MIC = 64 uM||Anti-methicillin-resistant S-aureus C623, activity value is MIC > 64 uM||Anti-C. albicans C627, activity value is MIC = 32 uM American plaice AP1, Hippoglossoides platessoides Fabricius|||Hippoglossoides platessoides [American plaice]|||Hippoglossoides platessoides [American plaice]|||American plaice AP1, Hippoglossoides platessoides Fabricius|||American plaice AP1, Hippoglossoides platessoides Fabricius N/A N/A 2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003.|||Reference: Patel S, Stott I P, Bhakoo M, Elliott P (1988) Patenting computer-designed peptides. Journal of Computer-Aided Molecular Design, 12: 543–556.|||Reference: Patel S, Stott I P, Bhakoo M, Elliott P (1988) Patenting computer-designed peptides. Journal of Computer-Aided Molecular Design, 12: 543–556.|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed.|||Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.PubMed. 25 FPDB02058 AP00804 GFCRCVCTRGFCRCVCTR Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-and C. albicans 16820. Active against drug resistant C. albicans clinical isolates, activity value is MIC = 12.5 olive baboon, Papio anubis and blood leukocytes, Papio hamadryas Bridge N/A Infect Immun. 2008 Dec;76(12):5883-91.|||Infect Immun. 2008 Dec;76(12):5883-91.||Basso et al., 2018 18 FPDB02071 AP00821|||DRAMP01946|||AP00821|||DRAMP01946 GLFNVFKGLKTAGKHVAGSLLNQLKCKVSGGC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-S. aureus, activity value is MIC = 10 uM||Anti-E. coli, activity value is MIC = 2 uM||Anti-and C. albicans, activity value is MIC = 40 uM Rana Ornativentris, Asia|||Rana Ornativentris (Japanese mountain brown frog)|||Rana Ornativentris, Asia|||Rana Ornativentris (Japanese mountain brown frog) N/A N/A 2001 Nov;58(5):349-56. doi: 10.1034/j.1399-3011.2001.00947.x.|||J Pept Res. 2001 Nov;58(5):349-356.|||J Peptide Res 2001; 58: 349-356. PubMed.|||J Pept Res. 2001 Nov;58(5):349-356.|||J Peptide Res 2001; 58: 349-356. PubMed. 32 FPDB02072 AP00822|||Brevinin-20b|||DRAMP01947|||Brevinin-20b|||AP00822|||DRAMP01947|||AP00822 GIFNVFKGALKTAGKHVAGSLLNQLKCKVSGEC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-||Anti-Escherichia coli, activity value is MIC = 4 uM||Anti-Staphylococcus aureus, activity value is MIC = 9 uM||Anti-Candida albicans, activity value is MIC = 40 uM||Anti-S. aureus, activity value is MIC = 9 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-and C. albicans, activity value is MIC = 40 uM Rana Ornativentris, Asia|||Rana ornativentris|||Rana Ornativentris (Japanese mountain brown frog)|||Rana ornativentris|||Rana Ornativentris, Asia|||Rana Ornativentris (Japanese mountain brown frog)|||Rana Ornativentris, Asia N/A N/A 2001 Nov;58(5):349-56. doi: 10.1034/j.1399-3011.2001.00947.x.|||11892844|||J Pept Res. 2001 Nov;58(5):349-356.|||11892844|||J Peptide Res 2001; 58: 349-356. PubMed.|||J Pept Res. 2001 Nov;58(5):349-356.|||J Peptide Res 2001; 58: 349-356. PubMed. 33 FPDB02076 AP00827|||Ranatuerin-1Ga|||DRAMP02239|||Ranatuerin-1Ga|||AP00827|||AP00827 SMISVLKNLGKVGLGFVACKVNKQC Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Escherichia coli, activity value is MIC = 9 uM||Anti-Staphylococcus aureus, activity value is MIC = 18 uM||Anti-Candida albicans, activity value is MIC = 70 uM||Anti-Escherichia coli, activity value is MIC = 3.5 uM||Anti-Staphylococcus aureus, activity value is MIC = 60 uM||Anti-S. aureus, activity value is MIC = 60 uM||Anti-E. coli, activity value is MIC = 3.5 uM||Anti-and C. albicans, activity value is MIC = 110 uM Rana grylio, North America|||Rana grylio [Pig frog]|||Rana zhenhaiensis (Chinese brown frog)|||Rana grylio [Pig frog]|||Rana grylio, North America|||Rana grylio, North America N/A ranatuerin-1Ga: 100 uMranatuerin-2G: 35 uMtemporin-1Gb: 16 uMtemporin-1Gd: 4 uM|||EC₅₀=100 uM 2000 Jun 30;90(1-3):53-60. doi: 10.1016/s0167-0115(00)00107-5.|||10828493|||Regul Pept. 2000 Jun 30;90(1-3):53-60.|||10828493|||Regul Pept 2000; 90: 53-60. PubMed.|||Regul Pept 2000; 90: 53-60. PubMed. 25 FPDB02077 AP00829|||Ranalexin-1G|||Ranalexin-1G|||AP00829|||DRAMP01359|||AP00829 FLGGLMKIIPAAFCAVTKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Antifungal ; Synthetic construct||Anti-Escherichia coli, activity value is MIC = 9 uM||Anti-Staphylococcus aureus, activity value is MIC = 18 uM||Anti-Candida albicans, activity value is MIC = 70 uM||Anti-S. aureus, activity value is MIC = 18 uM||Anti-E. coli, activity value is MIC = 9 uM||Anti-and C. albicans, activity value is MIC = 70 uM Rana grylio, North America|||Synthetic construct|||Rana grylio, North America|||Rana grylio (North American pig frog) N/A ranatuerin-1Ga: 100 uMranatuerin-2G: 35 uMtemporin-1Gb: 16 uMtemporin-1Gd: 4 uM|||Escherichia coli ( MIC = 9 uM ), Staphylococcus aureus ( MIC = 18 uM ), Candida albicans ( MIC = 70 uM ) 2000 Jun 30;90(1-3):53-60. doi: 10.1016/s0167-0115(00)00107-5.|||https://pubmed.ncbi.nlm.nih.gov/10828493|||10828493|||Regul Pept 2000; 90: 53-60. PubMed.|||Regul Pept 2000; 90: 53-60. PubMed. 20 FPDB02101 AP00855 GICRCVCTRGFCRCICLL Anti-Gram+ & Gram-||Antifungal||candidacidal Papio anubis Bridge N/A Infect Immun. 2008 Dec;76(12):5883-91. 18 FPDB02102 AP00856 GFCRCFCRRGVCRCVCTR Anti-Gram+ & Gram-||Antifungal||candidacidal Papio anubis Bridge N/A Infect Immun. 2008 Dec;76(12):5883-91. 18 FPDB02117 AP00881 SLLGTVKDLLIGAGKSAAQSVLKGLSGKLSKDC Anti-Gram+ & Gram-||Antifungal||candidacidal Huia schmackeri (formerly Rana (Odorrana) schmackeri), China, Asia N/A N/A 2008 Aug;29(8):1456-60. doi: 10.1016/j.peptides.2008.03.009. Epub 2008 Mar 16.|||Peptides. 2008 Aug;29(8):1456-60. PubMed. 33 FPDB02119 AP00885|||Brevinin-1BYb|||DRAMP01961|||Brevinin-1BYb|||AP00885|||DRAMP01961|||AP00885 FLPILASLAAKLGPKLFCLVTKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Escherichia coli, activity value is MIC = 16 uM||Anti-Candida albicans, activity value is MIC = 16 uM||Antimicrobial||Anti-Gram+||Anti-Gram- Rana boylii, North America|||Rana boylii [Foothill yellow-legged frog]|||Rana boylii (Foothill yellow-legged frog)|||Rana boylii [Foothill yellow-legged frog]|||Rana boylii, North America|||Rana boylii (Foothill yellow-legged frog)|||Rana boylii, North America N/A "Brevinin-1BYa: HC₅₀ = 4 uM Brevinin-1BYb: HC₅₀ = 4 uM Brevinin-1BYc: ND (Not Determined) Ranatuerin-2BYa: HC₅₀ = 120 uM Ranatuerin-2BYb: HC₅₀ > 200 uM Temporin-1BYa: ND (Not Determined)|||HC₅₀ = 4 uM" 2003 Nov;62(5):207-13. doi: 10.1034/j.1399-3011.2003.00090.x.|||14531844|||J Pept Res. 2003 Nov;62(5):207-213.||Ref.14531844|||14531844|||J Pept Res 2003; 62:207-213. PubMed.|||J Pept Res. 2003 Nov;62(5):207-213.|||J Pept Res 2003; 62:207-213. PubMed. 24 FPDB02120 AP00886|||Brevinin-1BYc|||DRAMP01962|||Brevinin-1BYc|||AP00886|||DRAMP01962|||AP00886 FLPILASLAATLGPKLLCLITKKC Anti-Gram+||Antifungal||candidacidal||Antibacterial||Antimicrobial||Anti-C. albicans, activity value is MIC = 35 uM||Anti-E.coli, activity value is MIC > 50 uM||Anti-and S. aureus, activity value is MIC = 8 uM Rana boylii, North America|||Rana boylii [Foothill yellow-legged frog]|||Rana boylii (Foothill yellow-legged frog)|||Rana boylii [Foothill yellow-legged frog]|||Rana boylii, North America|||Rana boylii (Foothill yellow-legged frog)|||Rana boylii, North America N/A "Brevinin-1BYa: HC₅₀ = 4 uM Brevinin-1BYb: HC₅₀ = 4 uM Brevinin-1BYc: ND (Not Determined) Ranatuerin-2BYa: HC₅₀ = 120 uM Ranatuerin-2BYb: HC₅₀ > 200 uM Temporin-1BYa: ND (Not Determined)" 2003 Nov;62(5):207-13. doi: 10.1034/j.1399-3011.2003.00090.x.|||14531844|||J Pept Res. 2003 Nov;62(5):207-213.|||14531844|||J Pept Res 2003; 62:207-213. PubMed.|||J Pept Res. 2003 Nov;62(5):207-213.|||J Pept Res 2003; 62:207-213. PubMed. 24 FPDB02130 AP00898|||Temporin-1Sa|||Sha|||AP00898|||DRAMP01780|||Temporin-1Sa|||AP00898|||DRAMP01780 FLSGIVGMLGKLF Anti-S. aureus ATCC 25923, activity value is MIC = 3 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 10 uM||Anti-negative E. coli ATCC 25922 or ATCC 35218, activity value is MIC = 10 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 31 uM||Anti-C. albicans ATCC 90028, activity value is MIC = 16 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 31 uM||Anti-and S. cerevisiae, activity value is MIC = 8 uM||Anti-B. megaterium, activity value is MIC = 2 uM||Anti-E. coli ATCC 25922, activity value is MIC = 10 uM||Anti-E. coli ATCC 35218, activity value is MIC = 10 uM||Anti-S. cerevisiae, activity value is MIC = 8 uM||Anti-Listeria ivanovii, activity value is MIC = 6 uM||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Hemolytic||Antibiofilm||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Bacillus megaterium, activity value is MIC = 2 uM||Anti-Escherichia coli, activity value is MIC = 10 uM||Antibacterial Pelophylax saharica, North Africa|||Pelophylax saharica [Sahara frog]|||Synthetic construct|||Pelophylax saharica, North Africa|||Pelophylax saharica (North Africa)|||Pelophylax saharica [Sahara frog]|||Pelophylax saharica, North Africa|||Pelophylax saharica (North Africa) Helix||Alpha helix "Temporin-1Sa: LC₅₀ value is 25 uM. Temporin-1Sb: LC₅₀ value is greater than 116 uM. Temporin-1Sc: LC₅₀ value is greater than 80 uM.|||Erythrocytes ( LC50 = 25 uM)|||According to the document, the hemolytic values of three novel temporin peptides (temporin-1Sa, -1Sb, -1Sc) derived from the skin of the North African Sahara frog (Pelophylax saharica) are expressed as the half-maximal hemolytic concentration (LC_{50}), as detailed below: temporin-1Sa: The LC_{50} against human red blood cells is 25 μM, exhibiting moderate hemolytic activity, and its hemolytic concentration (25 μM) is higher than the minimum inhibitory concentration (MIC, 2–31 μM) for most tested strains. temporin-1Sb: The LC_{50} against human red blood cells is greater than 116 μM, showing no significant hemolytic activity; even at a concentration as high as 116 μM, the hemolysis rate does not reach 50%. temporin-1Sc: The LC_{50} against human red blood cells is greater than 80 μM, showing no significant hemolytic activity; even at a concentration as high as 80 μM, the hemolysis rate does not reach 50%. Note: LC_{50} refers to the peptide concentration that induces 50% hemolysis of human red blood cells. It is determined by incubating synthetic peptides at different concentrations (1–200 μM) with fresh human red blood cells for 1 hour and measuring the absorbance at 450 nm. The 0.1% Triton X-100 treated group is used as a 100% hemolysis control.|||Erythrocytes ( LC50 = 25 uM)|||The document mentions the hemolytic-related values of three temporin peptides secreted by the skin of the Sahara frog (Pelophylax saharica), as follows: - temporin-1Sa: the half-maximal hemolytic concentration (LC_{50}) against human red blood cells is 25 µM. - temporin-1Sb: showed no significant hemolytic activity at the tested concentration (>116 µM). - temporin-1Sc: showed no significant hemolytic activity at the tested concentration (>80 µM). In the experiment, the 0.1% Triton X-100 treatment group was used as a 100% hemolysis control, and the hemolysis rate was calculated by measuring the absorbance at 450 nm. The results showed that the hemolytic activity of temporin-1Sa was moderate and higher than its minimum inhibitory concentration (MIC) against most bacterial strains.|||highly hemolytic, 50% hemolysis at 25 uM." 2008 Sep;29(9):1526-33. doi: 10.1016/j.peptides.2008.05.008. Epub 2008 May 18.|||18584916|||30813478|||Peptides. 2008 Sep;29(9):1526-3. Pub-Med|||Biomolecules. 2019 Oct 11;9(10):598.|||31614561|||18584916|||Peptides. 2008 Sep;29(9):1526-3. Pub-Med 13 FPDB02132 AP00900|||Temporin-1Sc|||Temporin-1Sc|||AP00900|||AP00900 FLSHIAGFLSNLF Anti-Gram+||Antifungal||candidacidal||Anti-S. aureus ATCC 25923, activity value is MIC = 10 uM||Anti-E. faecalis ATCC 29212, activity value is MIC > 80 uM||Anti-B. megaterium, activity value is MIC = 4 uM||Anti-E. coli ATCC 25922, activity value is MIC = 161 uM||Anti-E. coli ATCC 35218, activity value is MIC > 80 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC > 161 uM||Anti-A. flavus, activity value is MIC = 10 uM||Anti-C. albicans ATCC 90028, activity value is MIC = 20 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 20 uM||Anti-S. cerevisiae, activity value is MIC = 10 uM||Antibacterial Pelophylax saharica , North Africa|||Pelophylax saharica [Sahara frog]|||Pelophylax saharica [Sahara frog]|||Pelophylax saharica , North Africa|||Pelophylax saharica , North Africa Helix Temporin-1Sa: LC₅₀ value is 25 uM. Temporin-1Sb: LC₅₀ value is greater than 116 uM. Temporin-1Sc: LC₅₀ value is greater than 80 uM.|||Erythrocytes ( LC50 > 80 uM)|||Erythrocytes ( LC50 > 80 uM) 2008 Sep;29(9):1526-33. doi: 10.1016/j.peptides.2008.05.008. Epub 2008 May 18.|||18584916|||18584916|||Peptides. 2008 Sep;29(9):1526-3. Pub-Med|||Peptides. 2008 Sep;29(9):1526-3. Pub-Med 13 FPDB02160 AP00993|||Antimicrobial peptide D2|||DRAMP00403|||AP00993|||DRAMP00403|||AP00993 GIFSSRKCKTPSKTFKGICTRDSNCDTSCRYEGYPAGDCKGIRRRCMCSKPC Anti-bacteria C. michiganensis, activity value is EC50 = 1 uM||Anti-R. solanacearum, activity value is EC50 = 2 uM||Anti-F. solani, activity value is EC50 = 11 uM||Anti-C. lagenarium, activity value is EC50 = 11 uM||Anti-B. maydis, activity value is EC50 = 11 uM||Anti-S-nodorum, activity value is EC50 > 20 uM||Anti-and T-viridae, activity value is EC50 > 20 uM||Antibacterial||Antifungal ; Clavibacter michiganensis||Ralstonia solanacearum||F.culmorum||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Gram+ & Gram-||candidacidal leaf, Spinacia oleracea|||Spinacia oleracea [Spinach]|||Spinacia oleracea (Spinach)|||leaf, Spinacia oleracea|||Spinacia oleracea (Spinach)|||leaf, Spinacia oleracea Bridge N/A 1998 Sep 18;435(2-3):159-62. doi: 10.1016/s0014-5793(98)01060-6.|||9762899|||FEBS Lett. 1998; 435: 159-162.|||FEBS Lett. 1998 Sep 18;435(2-3):159-62. PubMed.|||FEBS Lett. 1998; 435: 159-162.|||FEBS Lett. 1998 Sep 18;435(2-3):159-62. PubMed. 52 FPDB02173 AP01008 YGNGVFSVIK Anti-Gram+ & Gram-||Antifungal||candidacidal Lactobacillus plantarum SLG1 from yak cheese Nonhelixbeta N/A Food Control 2018 Feb;84:111-117.|||Food Control 2018 Feb;84:111-117. SciDirect 10 FPDB02181 AP01037|||Cycloviolacin O3|||AP01037|||DRAMP00806 GIPCGESCVWIPCLTSAIGCSCKSKVCYRN Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Anti-Escherichia coli, activity value is MIC = 10 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 10 uM||Anti-Staphylococcus aureus, activity value is MIC = 20 uM||Anti-Candida albicans, activity value is MIC = 20 uM||Insecticidal Viola odorata|||Viola odorata L. and Viola tricolor L|||Viola odorata|||Viola odorata (Sweet violet) Bridge N/A 1999 Dec 17;294(5):1327-36. doi: 10.1006/jmbi.1999.3383.|||28669767|||J Mol Biol. 1999 Dec 17;294(5):1327-36. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12.J Mol Biol. 1999 Dec 17;294(5):1327-1336. 30 FPDB02185 AP01071|||Cycloviolacin O19|||AP01071|||DRAMP00822 GTLPCGESCVWIPCISSVVGCSCKSKVCYKD Anti-E. coli, activity value is MIC = 10 uM||Anti-P. aeruginosa, activity value is MIC = 10 uM||Anti-S. aureus, activity value is MIC = 10 uM||Anti-and C. albicans, activity value is MIC = 20 uM||Anti-plant fungi F. oxysporum, activity value is MIC = 12.5||Anti-B. cinerea, activity value is MIC = 1.5 uM||Anti-F. graminearum, activity value is MIC = 12.5 uM||Anti-F. culmorum, activity value is MIC = 1.5 uM||Anti-C. utrechtense, activity value is MIC = 6.25 uM||Anti-A. alternatam, activity value is MIC = 1.5 uM||Antibacterial||Anti-Gram+ & Gram-||Antifungal||candidacidal||Insecticidal Viola odorata|||Viola odorata L. and Viola tricolor L|||Viola odorata|||Viola odorata (Sweet violet) Bridge "Cyclic peptide O13: HD₅₀ is approximately 11 µM Cyclic peptide O14: HD₅₀ is approximately 11% hemolysis Cyclic peptide O24: HD₅₀ is approximately 75% hemolysis|||Peptides were dissolved in water and serially diluted in PBS to give 0.02 ml test solutions in a 96-well U-bottomed microtitre plate (Nunc). Human type A RBCs (red blood cells) were washed with PBS and centrifuged at 1500000000 ug for 60 s in a microcentrifuge several times until a clear supernatant was obtained. A 0.25% suspension of washed RBCs in PBS (0.1 ml) was added to the peptide solutions. The plate was incubated at 37◦Cfor 1 h and centrifuged at 150000000 ug for 0.083333 h. Aliquots of 0.1 mlweretransferred to a 96-well flat-bottomed microtitre plate (Falcon) and the absorbance was measured at 405 nm with an automatic Multiskan Ascent plate reader (Labsystems). The amount of haemolysis was calculated as the percentage ofmaximum lysis (1%Triton X-100 control) after adjusting for minimum lysis (PBS control). Synthetic melittin (Sigma) was used for comparison. The haemolytic dose necessary to lyse 50% of the RBCs (HD51) was calculated using the regression constant from the linear portion of the haemolytic titration curve (Graphpad Prism software)." 2006 Nov 15;400(1):1-12. doi: 10.1042/BJ20060627.||Strömstedt AA et al., 2017||Slazak et al. 2018|||28669767|||Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.||Strömstedt AA et al., 2017||Slazak et al. 2018|||Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12. 31 FPDB02197 AP01153|||Tachycitin|||AP01153 YLAFRCGRYSPCLDDGPNVNLYSCCSFYNCHKCLARLENCPKGLHYNAYLKVCDWPSKAGCT Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Escherichia coli, activity value is IC50 = 33 ug/ml||Anti-Escherichia coli B, activity value is IC50 = 2 ug/ml||Anti-Salmonella typhimurium LT2, activity value is IC50 = 44 ug/ml||Anti-Salmonella minnesota R595, activity value is IC50 = 41 ug/ml||Anti-Klebsiella pneumoniae, activity value is IC50 = 32 ug/ml||Anti-Staphyloccoccus aureus, activity value is IC50 = 56 ug/ml||Anti-Candida lbicans, activity value is IC50 = 52 ug/ml Tachypleus tridentatus|||Tachypleus tridentatus [Japanese horseshoe crab]|||Tachypleus tridentatus Beta N/A J Biochem. 1996 Dec;120(6):1253-60|||https://pubmed.ncbi.nlm.nih.gov/9010778|||J Biochem. 1996 Dec;120(6):1253-60 62 FPDB02201 AP01158|||Rp-1|||DRAMP04018|||Rp-1|||AP01158|||DRAMP03942|||DRAMP04018|||AP01158 ALYKKFKKKLLKSLKRLG Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal ; Staphylococcus||Streptococcus||Bacillus||Escherichia||Salmonella||Pseudomonas||Candida||Cryptococcus species platelet factor-4 protein derived peptide, Sequence truncation|||Synthetic construct|||Synthetic construct|||platelet factor-4 protein derived peptide, Sequence truncation|||Synthetic construct|||platelet factor-4 protein derived peptide, Sequence truncation Helix||Alpha helix Minimal cytotoxicity against relevant vascular tissues. Antimicrob Agents Chemother. 2002 Dec;46(12):3883-91|||18712851|||Biopolymers. 2009 Jan;91(1):1-13.|||18712851|||Antimicrob Agents Chemother. 2002 Dec;46(12):3883-91|||FEBS Lett. 1996 Jul 15;390(1):95-98.|||Biopolymers. 2009 Jan;91(1):1-13.|||Antimicrob Agents Chemother. 2002 Dec;46(12):3883-91 18 FPDB02203 AP01160|||Brazzein|||DRAMP00748|||AP01160|||DRAMP00748|||AP01160 QDKCKKVYENYPVSKCQLANQCNYDCKLDKHARSGECFYDEKRNLQCICDYCEY Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Antifungal ; Staphylococcus aureus ATCC 27217||Bacillus subtilis ATCC 6633||Escherichia coli strain ML-35||Candida albicans ATCC 36082||Antimicrobial||Anti-Gram+||Only very recently was antimicrobial property predicted based on the gamma-core motif and verified experimentally. Diffusion zone: Active against C. albicans (pH 7.5>pH 5.5). Only at pH 7.5||active against S. aureus||B. subtilis||E. coli. predicted based on the gamma-core motif; pulp, fruits, Pentadiplandra brazzeana Baillon|||Pentadiplandra brazzeana|||Pentadiplandra brazzeana|||identified based on the gamma-core motif; pulp, fruits, Pentadiplandra brazzeana Baillon|||Arabidopsis thaliana (Mouse-ear cress)|||identified based on the gamma-core motif; pulp, fruits, Pentadiplandra brazzeana Baillon Combine Helix and Beta structure||Combine helix and strand structure N/A Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.|||15118082|||Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-7368.|||Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.|||Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-7368.Nat Struct Biol. 1998 Jun;5(6):427-431.|||Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8. 54 FPDB02240 AP01210|||Jelleine-I|||F-J-I|||Cl-J-I|||Br-J-I|||I-J-I|||Jelleine-I|||AP01210|||AP01210 PFKLSLHL Anti-Gram+ bacteria S. aureus ATCC 6535, activity value is MIC = 10 ug/ml||Anti-S. saprophyticus, activity value is MIC = 15 ug/ml||Anti-B. subtilis CCT 2471, activity value is MIC = 10 ug/ml||Anti-and Gram- bacteria E. coli CCT 1371, activity value is MIC = 2.5 ug/ml||Anti-E. cloacae ACCT 23355, activity value is MIC = 10 ug/ml||Anti-K. pneumoniae ACCT 13883, activity value is MIC = 10 ug/ml||Anti-P. aeruginsa ACCT 27853, activity value is MIC = 10 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 2.5 ug/ml||Anti-Staphylococcus aureus ATCC 6535, activity value is MIC = 10 ug/ml||Anti-Staphylococcus saprophyticus, activity value is MIC = 15 ug/ml||Anti-Bacilus subtilis CCT 2471, activity value is MIC = 10 ug/ml||Anti-Escherichia coli CCT 1371, activity value is MIC = 2.5 ug/ml||Anti-Enterbacter cloacae ATCC 23355, activity value is MIC = 10 ug/ml||Anti-K. pneumoniae, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginsa, activity value is MIC = 10 ug/ml||Anti-C. albicans, activity value is MIC = 2.5 ug/ml||Anti-C. albicans ATCC 14053, activity value is MIC = 64 uM||Anti-C. tropicalis ATCC 750, activity value is MIC = 16 uM||Anti-C. krusei ATCC 6258, activity value is MIC = 32 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 64 uM||Anti-C. glabrata 02-Jan, activity value is MIC = 32 uM||Anti-C. albicans 14-Jan, activity value is MIC = 64 uM||Anti-C. albicans 14-Feb, activity value is MIC = 64 uM||Anti-C. albicans 14-Mar, activity value is MIC = 64 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 64 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 16 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 16 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 32 uM||Anti-Escherichia coli ATCC 43827, activity value is MIC = 32 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 32 uM||Anti-K. influenza ATCC 700603, activity value is MIC = 64 uM||Anti-C. sakazakii ATCC 29544, activity value is MIC = 32 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 32 uM||Anti-B. subtilis ATCC 23857, activity value is MIC = 8 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 16 uM||Anti-Escherichia coli ATCC 43827, activity value is MIC = 16 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 16 uM||Anti-K. influenza ATCC 700603, activity value is MIC = 16 uM||Anti-C. sakazakii ATCC 29544, activity value is MIC = 16 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 8 uM||Anti-C. sakazakii ATCC 29544, activity value is MIC = 8 uM||Anti-colistin-resistant K. pneumoniae, activity value is MIC = 16||Anti-K.pneumoniae 106 or 242, activity value is MIC = 128 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory||Synergistic AMPs honeybees, Apis mellifera|||Apis mellifera|||honeybees, Apis mellifera|||honeybees, Apis mellifera N/A "Jelleine-I: Hemolytic activity is 5.0 ± 1.3%. Jelleine-II: Hemolytic activity is 11.3 ± 2.8%. Jelleine-III: Hemolytic activity is 9.6 ± 1.9%. Jelleine-IV: Hemolytic activity is 3.1 ± 0.8%|||Mouse red blood cells(Non hemolytic at 256 uM)" 2004 Jun;25(6):919-28. doi: 10.1016/j.peptides.2004.03.016.|||15203237, 29101485||Refer PubMed ID: 29101485|||30500360|||https://pubmed.ncbi.nlm.nih.gov/15203237,||Refer PubMed ID: 29101485|||Peptides. 2004 Jun;25(6):919-28. Pub-Med.||Lima et al., 2025|||Peptides. 2004 Jun;25(6):919-28. Pub-Med. 8 FPDB02241 AP01211|||Jelleine-II|||Jelleine-II|||AP01211|||AP01211 TPFKLSLHL Anti-Active against G+ bacteria S. aureus ATCC 6535, activity value is MIC = 15 ug/ml||Anti-S. saprophyticus, activity value is MIC = 10 ug/ml||Anti-B. subtilis CCT 2471, activity value is MIC = 30 ug/ml||Anti-and G- bacteria E. coli CCT 1371, activity value is MIC = 15 ug/ml||Anti-E. cloacae ACCT 23355, activity value is MIC = 15 ug/ml||Anti-K. pneumoniae ACCT 13883, activity value is MIC = 15 ug/ml||Anti-P. aeruginsa ACCT 27853, activity value is MIC = 15 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 2.5 ug/ml||Anti-Staphylococcus aureus ATCC 6535, activity value is MIC = 15 ug/ml||Anti-Staphylococcus saprophyticus, activity value is MIC = 10 ug/ml||Anti-Bacilus subtilis CCT 2471, activity value is MIC = 30 ug/ml||Anti-Escherichia coli CCT 1371, activity value is MIC = 15 ug/ml||Anti-Enterbacter cloacae ATCC 23355, activity value is MIC = 15 ug/ml||Anti-K. pneumoniae, activity value is MIC = 15 ug/ml||Anti-Pseudomonas aeruginsa, activity value is MIC = 15 ug/ml||Anti-C. albicans, activity value is MIC = 2.5 ug/ml||Anti-G+ bacteria S. aureus ATCC 6535, activity value is MIC = 15 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal honeybees, Apis mellifera|||Apis mellifera|||honeybees, Apis mellifera|||honeybees, Apis mellifera N/A "Jelleine-I: Hemolytic activity is 5.0 ± 1.3%. Jelleine-II: Hemolytic activity is 11.3 ± 2.8%. Jelleine-III: Hemolytic activity is 9.6 ± 1.9%. Jelleine-IV: Hemolytic activity is 3.1 ± 0.8%" 2004 Jun;25(6):919-28. doi: 10.1016/j.peptides.2004.03.016.|||15203237|||https://pubmed.ncbi.nlm.nih.gov/15203237|||Peptides. 2004 Jun;25(6):919-28. Pub-Med.|||Peptides. 2004 Jun;25(6):919-28. Pub-Med. 9 FPDB02248 AP01220|||Ascaphin-5|||DRAMP01844|||AP01220|||DRAMP01844|||AP01220 GIKDWIKGAAKKLIKTVASNIANQ Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Escherichia coli, activity value is MIC = 6 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 13 uM||Anti-Enterobacter cloacae, activity value is MIC = 6 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 13 uM||Anti-Proteus mirabilis, activity value is MIC > 100 uM||Anti-Staphylococcus aureus, activity value is MIC = 50 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 13 uM||Anti-Enterococcus faecalis, activity value is MIC > 100 uM||Anti-Streptococcus Group B, activity value is MIC = 6 uM||Anti-Candida albicans, activity value is MIC = 100 uM Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Ascaphus truei [Coastal tailed frog]|||Ascaphus truei (Coastal tailed frog)|||Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Ascaphus truei (Coastal tailed frog)|||Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America N/A "Ascaphin-1: HC₅₀ > 200 uM. Ascaphin-3: HC₅₀ > 200 uM. Ascaphin-7: HC₅₀ > 200 uM. Ascaphin-8: Endogenous Ascaphin-8: HC₅₀ = 50 uM. Synthetic amidated Ascaphin-8: HC₅₀ = 55 uM. Ascaphin-5: HC₅₀ > 200 uM.|||In Biochemical and Biophysical Research Communications 2004, among the ascaphin family peptides isolated from the skin secretions of the tailed frog (Ascaphus truei), ascaphin-1, ascaphin-3, and ascaphin-7 had HC₅₀ values greater than 200 μM for human red blood cells, while ascaphin-8 had an HC₅₀ value of 50 μM for human red blood cells; synthetic ascaphin-1 (both free acid and amidated forms) and ascaphin-5 (free acid form) had HC₅₀ values greater than 200 μM for human red blood cells, and synthetic ascaphin-8 (amidated form) had an HC₅₀ value of 55 μM for human red blood cells.|||[Ref.15207717]Not found|||The therapeutic potential of ascaphin-8 as an antiinfective agent is limited by its moderately high haemolytic activity (HC50 ¼ 55 lM) In contrast, ascaphin-1 and ascaphin-5, although displaying high potencies only against Gram-negative bacteria, have very low haemolytic activities (HC50 >200 lM) compared with many other frog skin peptides. By way of comparison, the HC50 values of brevinin-1E from Rana esculenta [22] and temporin L from Rana temporaria [23] are less than 1 lM.|||[Ref.15207717]Not found" 2004 Jul 16;320(1):170-5. doi: 10.1016/j.bbrc.2004.05.141.|||15207717|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175.||Ref.15207717|||15207717||Ref.15207717|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed|||Ref.15207717|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed 24 FPDB02267 AP01247|||DRAMP03017|||AP01247|||DRAMP03017 FMPIIGRLMSGSL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Escherichia coli ATCC25922, activity value is MIC = 7.5 ug/ml||Anti-Escherichia coli 23A, activity value is MIC = 7.5 ug/ml||Anti-Escherichia coli 27A, activity value is MIC = 15 ug/ml||Anti-Pseudemonas aeruginosa 3A, activity value is MIC = 3.75 ug/ml||Anti-Pseudemonas aeruginosa 7A, activity value is MIC = 3.75 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 1.9 ug/ml||Anti-Staphylococcus aureus 6A, activity value is MIC = 3.75 ug/ml||Anti-Staphylococcus aureus 15A, activity value is MIC = 1 ug/ml||Anti-Fungus: Candida albicans ATCC2002, activity value is MIC = 30 ug/ml venom, wasps, Vespa bicolorFabricius|||vespine wasps Vespa bicolor|||venom, wasps, Vespa bicolorFabricius, Asia|||vespine wasps Vespa bicolor|||venom, wasps, Vespa bicolorFabricius, Asia N/A The document mentions that VESP-VB1 has a hemolysis rate of 10.2% for rabbit red blood cells and 3.2% for human red blood cells at a concentration of up to 200 µg/ml; MP-VB1 has hemolysis rates of 1.7% and 2.7% for rabbit and human red blood cells, respectively, at the same concentration, indicating that the hemolytic activity of these two peptides is extremely low.|||[Ref.18723059] VESP-VB1 had a little hemolytic activity of 10.2% against rabbit red blood cells, and of 3.2% against human red blood cells with peptide concentration up to 200 ug/ml Peptides. 2008 Nov;29(11):1887-92.|||Peptides. 2008 Nov;29(11):1887-1892.||Ref.18723059|||18723059||Ref.18723059|||Peptides. 2008 Nov;29(11):1887-92.|||Ref.18723059 13 FPDB02268 AP01248|||DRAMP03018|||AP01248|||DRAMP03018 " INMKASAAVAKKLL" Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Escherichia coli ATCC25922, activity value is MIC = 15 ug/ml||Anti-Escherichia coli 23A, activity value is MIC = 15 ug/ml||Anti-Escherichia coli 27A, activity value is MIC = 60 ug/ml||Anti-Pseudemonas aeruginosa 3A, activity value is MIC = 15 ug/ml||Anti-Pseudemonas aeruginosa 7A, activity value is MIC = 120 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 3.75 ug/ml||Anti-Staphylococcus aureus 6A, activity value is MIC = 1.9 ug/ml||Anti-Staphylococcus aureus 15A, activity value is MIC = 3.75 ug/ml||Anti-Fungus: Candida albicans ATCC2002, activity value is MIC = 15 ug/ml venom, wasps, Vespa bicolor Fabricius|||vespine wasps Vespa bicolor|||venom, wasps, Vespa bicolor Fabricius, Asia|||vespine wasps Vespa bicolor|||venom, wasps, Vespa bicolor Fabricius, Asia N/A "The document mentions that VESP-VB1 has a hemolysis rate of 10.2% for rabbit red blood cells and 3.2% for human red blood cells at a concentration of up to 200 µg/ml; MP-VB1 has hemolysis rates of 1.7% and 2.7% for rabbit and human red blood cells, respectively, at the same concentration, indicating that the hemolytic activity of these two peptides is extremely low.|||VESP-VB1: Hemolysis rate on rabbit red blood cells is 10.2%, and on human red blood cells is 3.2%; • MP-VB1: Hemolysis rate on rabbit red blood cells is only 1.7%, and on human red blood cells is 2.7%.|||[Ref.18723059] MP-VB1 had almost no hemolytic activity of 1.7% and 2.7% against rabbit and human red blood cells" Peptides. 2008 Nov;29(11):1887-92|||Peptides. 2008 Nov;29(11):1887-1892.||Ref.18723059|||Peptides. 2008 Nov;29(11):1887-92|||Ref.18723059 14 FPDB02270 AP01250|||Ranacyclin-T|||DRAMP02275|||Ranacyclin-T|||AP01250|||AP01250 GALRGCWTKSYPPKPCK Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Bacillus megaterium Bm11, activity value is MIC = 3 uM||Anti-Staphylococcus lentus, activity value is MIC = 10 uM||Anti-Micrococcus luteus, activity value is MIC = 8 uM||Anti-Escherichia coli D21, activity value is MIC = 30 uM||Anti-Yersinia pseudotuberculosis YP III, activity value is MIC = 5 uM||Anti-Pseudomonas syringae pv tabaci, activity value is MIC = 16 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 22 uM||Anti-Candida tropicalis, activity value is MIC = 14 uM||Anti-C. guillermondii, activity value is MIC = 1 uM||Anti-Phytophthora nicotianae spores, activity value is MIC = 16 uM||Antibacterial||Antifungal ; B.megaterium Bm11||S.lentus||M.luteus||E.coli D22||Y.pseudotuberculosis YP III||P.syringae pv tabaci||C.albicans ATCC 10231||C.tropicalis||C.guillermondii||P.nicotianae spores frog skin Rana esculenta, Europe|||Rana temporaria|||Rana temporaria (European common frog)|||frog skin Rana esculenta, Europe|||frog skin Rana esculenta, Europe N/A The document mentions that ranacyclin T, ranacyclin E, and pLR have hemolysis rates of 20%, 55%, and 85%, respectively, on human red blood cells at a concentration of 100 µM. This indicates that ranacyclin T has the lowest hemolytic activity, ranacyclin E is intermediate, and pLR has the highest hemolytic activity.|||In Document 5 (Biochemistry 2003), ranacyclin E, isolated from the skin secretions of the green frog (Rana esculenta), ranacyclin T, screened from the skin cDNA library of the common frog (Rana temporaria), and pLR, isolated from the skin of the leopard frog (Rana pipiens), all exhibit hemolytic activity; at a concentration of 100 μM, the hemolysis rate is 20% for ranacyclin T, 55% for ranacyclin E, and 85% for pLR. Biochemistry. 2003 Dec 2;42(47):14023-35|||14636071|||Biochemistry. 2003 Dec 2;42(47):14023-14035.||Ref.14636071|||14636071|||Biochemistry. 2003 Dec 2;42(47):14023-35|||Biochemistry. 2003 Dec 2;42(47):14023-35 17 FPDB02275 AP01255|||Brevinin-2PRc|||Brevinin-2PRc|||AP01255|||AP01255 GLMSVTKGVLKTAGKHIFKNVGGSLLDQAKCKISGQC Anti-E. coli, activity value is MIC = 3 uM||Anti-P. aeruginosa, activity value is MIC = 6 uM||Anti-E. cloacae, activity value is MIC = 6 uM||Anti-K. pneumoniae, activity value is MIC = 12 uM||Anti-S. aureus, activity value is MIC = 25 uM||Anti-and C. albicans, activity value is MIC = 100 uM||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 3 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 6 uM||Anti-Enterobacter cloacae NHTCC 53001, activity value is MIC = 6 uM||Anti-Klebsiella pneumoniae KK3 9904, activity value is MIC = 12 uM||Anti-Staphlococcus aureus NCTC 8325, activity value is MIC = 25 uM||Anti-Candida albicans, activity value is MIC = 100 uM||Anti-Gram+ & Gram-||candidacidal the Hokkaido frog, Rana pirica, Asia|||Rana pirica|||Rana pirica|||the Hokkaido frog, Rana pirica, Asia|||the Hokkaido frog, Rana pirica, Asia N/A "The document mentions the hemolytic values of various peptides, with the following specific information: brevinin-2PRa: Hemolytic concentration (HC₅₀) is 55 µM. brevinin-2PRb: HC₅₀ is 65 µM. brevinin-2PRc: HC₅₀ is 125 µM. brevinin-2PRd: HC₅₀ is 100 µM. brevinin-2PRe: HC₅₀ is 80 µM. ranatuerin-2PRa: HC₅₀ is 150 µM. brevinin-1PRa: HC₅₀ is 7 µM, showing strong hemolytic activity. temporin-1PRa and temporin-1PRb: No significant hemolysis was observed at a concentration of 300 µM.|||Human erythrocytes ( HC50 = 125 uM )|||Human erythrocytes ( HC50 = 125 uM )" 2004 May 15;118(3):135-41. doi: 10.1016/j.regpep.2003.12.003.|||15003829|||15003829|||Regul Pept. 2004 May 15;118(3):135-41. Pub-Med.|||Regul Pept. 2004 May 15;118(3):135-41. Pub-Med. 37 FPDB02278 AP01258|||Ranatuerin-2PRa|||DRAMP02242|||Ranatuerin-2PRa|||AP01258|||DRAMP02242|||AP01258 GLMDVFKGAAKNLLASALDKIRCKVTKC Anti-E. coli, activity value is MIC = 13 uM||Anti-S.aureus, activity value is MIC > 100 uM||Anti-and C. albicans, activity value is MIC = 100 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 13 uM||Anti-Staphlococcus aureus NCTC 8325, activity value is MIC > 100 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 100 uM||Anti-Candida albicans, activity value is MIC = 100 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||candidacidal the Hokkaido frog, Rana pirica, Asia|||Rana palustris [Pickerel frog]|||Rana pirica (Hokkaido frog)|||Rana pirica|||the Hokkaido frog, Rana pirica, Asia|||Rana pirica (Hokkaido frog)|||the Hokkaido frog, Rana pirica, Asia N/A "The document mentions the hemolytic values of various peptides, with the following specific information: brevinin-2PRa: Hemolytic concentration (HC₅₀) is 55 µM. brevinin-2PRb: HC₅₀ is 65 µM. brevinin-2PRc: HC₅₀ is 125 µM. brevinin-2PRd: HC₅₀ is 100 µM. brevinin-2PRe: HC₅₀ is 80 µM. ranatuerin-2PRa: HC₅₀ is 150 µM. brevinin-1PRa: HC₅₀ is 7 µM, showing strong hemolytic activity. temporin-1PRa and temporin-1PRb: No significant hemolysis was observed at a concentration of 300 µM.|||Human erythrocytes ( HC50 = 150 uM )|||Human erythrocytes ( HC50 = 150 uM )" 2004 May 15;118(3):135-41. doi: 10.1016/j.regpep.2003.12.003.|||15003829|||Regul Pept. 2004 May 15;118(3):135-141.|||15003829|||Regul Pept. 2004 May 15;118(3):135-41. Pub-Med.|||Regul Pept. 2004 May 15;118(3):135-141.|||Regul Pept. 2004 May 15;118(3):135-41. Pub-Med. 28 FPDB02282 AP01264|||RV-23|||RV-23|||AP01264|||DRAMP01826|||AP01264 " RIGVLLARLPKLFSLFKLMGKKV" Anti-E. coli, activity value is MIC = 2.5 uM||Anti-S. aureus, activity value is MIC = 40 uM||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 2.5 uM||Anti-Staphylococcus aureus, activity value is MIC = 40 uM||Anti-Candida albicans, activity value is MIC = 80 uM||Anti-K. pneumoniae ATCC 10031, activity value is MIC = 6.25 uM||Antimicrobial||Anti-Gram+||Anti-Gram-||Anti-Gram+ & Gram-||Antiviral||candidacidal||Hemolytic Rana draytonii, North America|||Rana draytonii [California red-legged frog]|||Synthetic construct|||Rana draytonii, North America|||Rana aurora draytonii (California red-legged frog) Helix "RV-23: Hemolytic concentration (LC₅₀) is 35 uM. temporin-1DRa: LC₅₀ is 70 uM. temporin-1DRb: LC₅₀ is 65 uM|||Escherichia coli ( MIC = 2.5 uM ), Staphylococcus aureus ( MIC = 40 uM ), Candida albicans ( MIC = 80 uM )|||Human RBC (2.56 ± 0.41% hemolysis at 6 uM)|||Human erythrocytes ( IC50 = 35 uM )|||The document mentions the hemolytic values of three peptides (expressed as LC_{50}, that is, the peptide concentration that induces 50% hemolysis), as follows: - RV-23: LC_{50} = 35 μM - Temporin-1DRa: LC_{50} = 70 μM - Temporin-1DRb: LC_{50} = 65 μM These values come from tests on peptides synthesized from the skin secretions of Rana aurora draytonii and reflect their hemolytic activity against human red blood cells." Peptides. 2006 Jun;27(6):1305-12|||16307827|||26975766|||16307827|||Peptides. 2006 Jun;27(6):1305-12|||Peptides. 2006 Jun;27(6):1305-1312.Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.|||Peptides. 2006 Jun;27(6):1305-12 23 FPDB02283 AP01265|||CAMPSQ3140|||CAMPSQ9510|||DRAMP01825|||Temporin-1DRa|||AP01265|||DRAMP01825|||AP01265 " HFLGTLVNLAKKIL" Anti-E. coli, activity value is MIC = 20 uM||Anti-S. aureus, activity value is MIC = 5 uM||Anti-P. acnes, activity value is MIC = 30 uM||Anti-Escherichia coli, activity value is MIC = 20 uM||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-Candida albicans, activity value is MIC = 40 uM||Anti-L. plantarum WCFS1, activity value is MIC = 64 ug/ml||Anti-L. rhamnosus LGG, activity value is MIC = 32 ug/ml||Anti-L. salivarius DSM20554, activity value is MIC = 64 ug/ml||Anti-L. salivarius FortaFit Ls-33, activity value is MIC = 64 ug/ml||Anti-L. casei R0215, activity value is MIC = 64 ug/ml||Anti-L. casei Shirota, activity value is MIC = 32 ug/ml||Anti-L. reuteri ATCC5730, activity value is MIC = 32 ug/ml||Anti-L. acidophilus LA5, activity value is MIC = 64 ug/ml||Anti-S. aureus DMS20231, activity value is MIC = 64 ug/ml||Anti-S. aureus Sens 8325.4, activity value is MIC = 8 ug/ml||Anti-S. aureus MRSA B33424, activity value is MIC = 8 ug/ml||Anti-S. pseudintermedium E138, activity value is MIC = 8 ug/ml||Anti-S. pseudintermedium E139, activity value is MIC = 8 ug/ml||Anti-S. pseudintermedium E140, activity value is MIC = 8 ug/ml||Anti-S. pseudintermedium S70E2, activity value is MIC = 8 ug/ml||Antimicrobial||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Hemolytic Rana draytonii, North America|||Rana draytonii [California red-legged frog]|||Rana draytonii|||Rana aurora draytonii (California red-legged frog)|||Rana draytonii [California red-legged frog]|||Rana draytonii, North America|||Rana aurora draytonii (California red-legged frog)|||Rana draytonii, North America N/A "RV-23: Hemolytic concentration (LC₅₀) is 35 uM. temporin-1DRa: LC₅₀ is 70 uM. temporin-1DRb: LC₅₀ is 65 uM|||Human erythrocytes ( IC50 = 70 uM )|||RV-23 has strong hemolytic activity (LC50 = 35 µM), while also having high antibacterial activity. Temporin-1DRa and Temporin-1DRb also have significant hemolytic activity (LC50 of 70 µM and 65 µM, respectively). The authors point out that the hemolytic activity of these peptides is one of the main limiting factors for their potential as antimicrobial peptide therapeutics.|||Human erythrocytes ( IC50 = 70 uM )" Peptides. 2006 Jun;27(6):1305-12||Wu et al., 2020|||16307827|||31102497|||Peptides. 2006 Jun;27(6):1305-1312.|||16307827|||Peptides. 2006 Jun;27(6):1305-12||Wu et al., 2020|||Peptides. 2006 Jun;27(6):1305-1312.|||Peptides. 2006 Jun;27(6):1305-12 14 FPDB02285 AP01267|||DRAMP02698|||Oral Mucosal Alpha-Defensin|||AP01267|||DRAMP02698 RRTCHCRSRCLRRESNSGSCNINGRIFSLCCR Road-1 is active against S. aureus||E. coli||and C. albicans in a concentration-dependent manner. Updated 2/2014.||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Gram+ & Gram-||candidacidal Rhesus Macaque, Macaca mulatta|||Macaca mulatta (Rhesus monkey)|||Macaca mulatta [Rhesus macaque]|||Rhesus Macaque, Macaca mulatta|||Macaca mulatta (Rhesus monkey)|||Rhesus Macaque, Macaca mulatta Beta||Beta strand (3 strands; 19 residues) N/A J Biol Chem. 2008 Dec 19;283(51):35869-77|||J Biol Chem. 2008 Dec 19;283(51):35869-35877.|||18930922|||J Biol Chem. 2008 Dec 19;283(51):35869-77|||J Biol Chem. 2008 Dec 19;283(51):35869-35877. 32 FPDB02287 AP01270 " SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL" Anti-E. coli, activity value is MBC = 10 ug/ml||Anti-E. faecalis, activity value is MBC = 10 ug/ml||Anti-S. aureus, activity value is MBC = 10 ug/ml||Anti-and C. albicans, activity value is MBC = 100 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Eccrine sweat glands, skin, Homo sapiens|||Eccrine sweat glands, skin, Homo sapiens Helix N/A 2001 Dec;2(12):1133-7. doi: 10.1038/ni732.|||Nat Immunol. 2001 Dec;2(12):1133-7. doi: 10.1038/ni732. B Schittek et al., 2001 48 FPDB02296 AP01291|||Odorranain-B1 antimicrobial peptide|||DRAMP01372|||Odorranain-B1 antimicrobial peptide|||AP01291|||DRAMP01372|||AP01291 " AALKGCWTKSIPPKPCFGKR" Anti-Gram+ & Gram-||Antifungal||candidacidal||Enzyme inhibitor||Antibacterial ; Synthetic construct||Anti-E. coli, activity value is MIC = 3.21 ug/ml||Anti-S. aureus, activity value is MIC = 5.83 ug/ml||Anti-B. subtilis, activity value is MIC = 1.85 ug/ml||Anti-C.albicans, activity value is MIC = 2.4 ug/ml||Anti-Escherichia coli, activity value is MIC = 16.32 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8.16 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 8.16 ug/ml||Anti-Escherichia coli, activity value is MIC = 3.21 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 5.83 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 1.85 ug/ml||Anti-Escherichia coli, activity value is MIC = 8.21 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4.11 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 16.42 ug/ml skin, Odorrana grahami, China, Asia|||Synthetic construct|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana hainanensis (Odor frog) (Rana hainanensis)|||skin, Odorrana grahami, China, Asia|||Odorrana hainanensis (Odor frog) (Rana hainanensis)|||skin, Odorrana grahami, China, Asia Helix "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||E. coli ( MIC = 3.21 ug/ml), S. aureus ( MIC = 5.83 ug/ml), B. subtilis ( MIC = 1.85 ug/ml), C.albicans ( MIC = 2.4 ug/ml)|||At a concentration of 200 μg/ml, ESP-VB1 caused a hemolysis rate of 10.2% for rabbit red blood cells and 3.2% for human red blood cells; MP-VB1 at the same concentration caused a hemolysis rate of 1.7% for rabbit red blood cells and 2.7% for human red blood cells, both showing extremely low hemolytic activity.|||[Ref:17272268] No detectable hemolytic activity against rabbit red blood cells.|||[Ref:17272268] No detectable hemolytic activity against rabbit red blood cells." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||https://pubmed.ncbi.nlm.nih.gov/17272268|||Mol Cell Proteomics. 2007 May;6(5):||Ref.17272268|||17272268||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Ref.17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 20 FPDB02297 AP01292|||Odorranain-C1|||DRAMP01373|||Odorranain-C1|||AP01292|||DRAMP01373|||AP01292 GVLGAVKDLLIGAGKSAAQSVLKTLSCKLSNDC Anti-E. coli ATCC 35150 or ATCC 10305, activity value is MIC = 8.2||Anti-S. aureus ATCC 25923, activity value is MIC = 4.1||Anti-B. subtilis, activity value is MIC = 12||Anti-L. monocytogenes ATCC 21633, activity value is MIC = 10 ug/ml||Anti-and C. albicans, activity value is MIC = 2.1 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 8.21 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4.11 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 16.42 ug/ml||Anti-Candida albicans, activity value is MIC = 2.05 ug/ml||Anti-Gram+ & Gram-||candidacidal skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||skin, Odorrana grahami, China, Asia Helix "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||[Ref:17272268] No detectable hemolytic activity against rabbit red blood cells." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||17272268||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Ref.17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 33 FPDB02298 AP01293|||OdD1|||DRAMP01373|||DRAMP01374|||OdD1|||AP01293|||DRAMP01374|||AP01293 GFLDTFKNLALNAAKSAGVSVLNSLSCKLFKTC Anti-E. coli, activity value is MIC = 16.3 ug/ml||Anti-S. aureus, activity value is MIC = 8.2 ug/ml||Anti-B. subtilis, activity value is MIC = 8.2 ug/ml||Anti-and C. albicans, activity value is MIC = 4.1 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 8.21 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4.11 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 16.42 ug/ml||Anti-Escherichia coli, activity value is MIC = 16.32 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8.16 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 8.16 ug/ml||Anti-Candida albicans, activity value is MIC = 4.08 ug/ml||Anti-Gram+ & Gram-||candidacidal skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||skin, Odorrana grahami, China, Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||At a concentration of 200 μg/ml, ESP-VB1 caused a hemolysis rate of 10.2% for rabbit red blood cells and 3.2% for human red blood cells; MP-VB1 at the same concentration caused a hemolysis rate of 1.7% for rabbit red blood cells and 2.7% for human red blood cells, both showing extremely low hemolytic activity.|||At a concentration of 50 µg/ml, the hemolysis rate of Odorranain-A1 was 12.7%, Odorranain-F1 was 15.4%, Odorranain-H1 was 21.6%, Odorranain-L1 was 18.3%, Odorranain-M1 was 8.2%, Odorranain-P1a was 11.2%, Odorranain-P2a was 15.2%, Odorranain-Q1 was 22.9%, Odorranain-V1 was 23.9%, Odorranain-W1 was 17.6%, Nigrocin-OG2 was 60.0%, Nigrocin-OG4 was 65.5%, Nigrocin-OG5 was 87.2%, Nigrocin-OG21 was 100%.|||[Ref:17272268]Non-hemolytic activity against rabbit red blood cells|||[Ref:17272268]Non-hemolytic activity against rabbit red blood cells" 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):||Ref.17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Ref.17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 33 FPDB02299 AP01294|||OdE1|||DRAMP01375|||OdE1|||AP01294|||DRAMP01375|||AP01294 " GLGGAKKNFIIAANKTAPQSVKKTFSCKLYNG" Anti-E. coli, activity value is MIC = 9.4 ug/ml||Anti-S. aureus, activity value is MIC = 4.7 ug/ml||Anti-B. subtilis, activity value is MIC = 4.7 ug/ml||Anti-and C. albicans, activity value is MIC = 9.4 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 9.37 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4.68 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 4.68 ug/ml||Anti-Candida albicans, activity value is MIC = 9.37 ug/ml||Antimicrobial||Anti-Gram+||Anti-Gram-||Anti-Gram+ & Gram-||candidacidal skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||skin, Odorrana grahami, China, Asia Helix "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||not hemo-lytic at 50 ug/ml." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-894.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 32 FPDB02300 AP01295 GFMDTAKNVAKNVAVTLIDNLKCKITKAC Anti-E. coli, activity value is MIC = 4.2 ug/ml||Anti-S. aureus, activity value is MIC = 2.1 ug/ml||Anti-B. subtilis, activity value is MIC = 8.4 ug/ml||Anti-and C. albicans, activity value is MIC = 1.1 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic skin, Odorrana grahami, China, Asia|||skin, Odorrana grahami, China, Asia Helix "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||15.4% hemolysis at 50 ug/ml." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 29 FPDB02301 AP01296|||OdG1|||DRAMP01377|||OdG1|||AP01296|||AP01296 FMPILSCSRFKRC Anti-E. coli, activity value is MIC = 4.7 ug/ml||Anti-S. aureus, activity value is MIC = 9.4 ug/ml||Anti-B. subtilis, activity value is MIC = 37.5 ug/ml||Anti-and C. albicans, activity value is MIC = 1.1 ug/ml||Anti-Escherichia Coli, activity value is MIC = 4.68 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 9.37 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans, activity value is MIC = 1.1 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||skin, Odorrana grahami, China, Asia Helix "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||not hemo-lytic at 50 ug/ml." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 13 FPDB02302 AP01297|||Odorranain-H1|||Odorranain-H1|||AP01297|||AP01297 GIFGKILGVGKKVLCGLSGWC Anti-E. coli, activity value is MIC = 23.6 ug/ml||Anti-S. aureus, activity value is MIC = 5.9 ug/ml||Anti-B. subtilis, activity value is MIC = 5.9 ug/ml||Anti-and C. albicans, activity value is MIC = 11.8 ug/ml||Anti-Escherichia coli, activity value is MIC = 23.6 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 5.9 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 5.9 ug/ml||Anti-Candida albicans, activity value is MIC = 11.8 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia Helix "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||21.6% hemolysis at 50 ug/ml." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 21 FPDB02303 AP01298|||Odorranain-J1 antimicrobial peptide|||DRAMP01380|||Odorranain-J1 antimicrobial peptide|||AP01298|||DRAMP01380|||AP01298 " GLFTLIKCAYQLIAPTVACN" Anti-E. coli, activity value is MIC = 35.6 ug/ml||Anti-S. aureus, activity value is MIC = 17.8 ug/ml||Anti-B. subtilis, activity value is MIC = 35.6 ug/ml||Anti-and C. albicans, activity value is MIC = 8.9 ug/ml||Antibacterial ; Synthetic construct||Anti-C.albicans, activity value is MIC = 8.9 ug/ml||Anti-Escherichia coli, activity value is MIC = 35.6 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 17.8 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 35.6 ug/ml||Antimicrobial||Antibacterial||Antifungal||Anti-Gram+||Anti-Gram-||Anti-Gram+ & Gram-||candidacidal skin, Odorrana grahami, China, Asia|||Synthetic construct|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||skin, Odorrana grahami, China, Asia|||Fagopyrum esculentum Moench (buckwheat)|||skin, Odorrana grahami, China, Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||E. coli ( MIC = 35.6 ug/ml), S. aureus ( MIC = 17.8 ug/ml), B. subtilis ( MIC = 35.6 ug/ml), C.albicans ( MIC = 8.9 ug/ml)|||At a concentration of 50 µg/ml, the positive control Triton X-100 showed 100% hemolysis; Odorranain-A1 showed 14.2 ± 5.6% hemolysis, Odorranain-F1 7.3 ± NA%, Odorranain-K1 18.3 ± 4.6%, Odorranain-L1 114.2 ± NA%, Odorranain-M1 7.7 ± 3.5%, Odorranain-O1 3.50 ± NA%, Odorranain-P2a 22.9 ± 8.5%, Odorranain-Q1 20.7 ± 1.3%, Odorranain-U1 5.2 ± 2.3%; Nigrocin-OG2 18.1 ± 7.7%, Nigrocin-OG4 22.3 ± 3.1%, Nigrocin-OG5 14.0 ± 5.2%, Nigrocin-OG20 17.0 ± 2.8%. The remaining antimicrobial peptides (including Odorranain-B1, C1, D1, E1, G1, H1, J1, N1, R1, S1, T1, V1, W1, and Nigrocin-OG13, OG21) showed no detectable hemolytic activity (marked as NA). All values are the mean ± standard deviation of three independent repeated experiments." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||https://pubmed.ncbi.nlm.nih.gov/17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Biosci Biotechnol Biochem. 2003 Aug;67(8):1636-1642.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 20 FPDB02304 AP01299|||Odorranain-k1 antimicrobial peptide|||DRAMP01381|||Odorranain-k1 antimicrobial peptide|||AP01299|||AP01299 " GLFTLIKGAAKLIGKTVPKKQARLGMNLWLVKLPTNVKT" Anti-E. coli, activity value is MIC = 4.7 ug/ml||Anti-S. aureus, activity value is MIC = 4.7 ug/ml||Anti-B. subtilis, activity value is MIC = 1.1 ug/ml||Anti-and C. albicans, activity value is MIC = 1.1 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 4.68 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4.68 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 1.1 ug/ml||Anti-E. coli, activity value is MIC = 4.68 ug/ml||Anti-S. aureus, activity value is MIC = 4.68 ug/ml||Anti-C.albicans, activity value is MIC = 1.1 ug/ml||Anti-Gram+ & Gram-||candidacidal skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||skin, Odorrana grahami, China, Asia N/A odorranain-F1: No obvious hemolysis. 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 39 FPDB02305 AP01300 ATAVDFGPHGLLPIRPIRIRPLCGKDKS Anti-E. coli, activity value is MIC = 9.4 ug/ml||Anti-S. aureus, activity value is MIC = 4.7 ug/ml||Anti-B. subtilis, activity value is MIC = 75 ug/ml||Anti-and C. albicans, activity value is MIC = 18.8 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal skin, Odorrana grahami, China, Asia|||skin, Odorrana grahami, China, Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 28 FPDB02306 AP01303|||OdP1a|||DRAMP01386|||OdP1a|||AP01303|||AP01303 " VIPFVASVAAEMMQHVYCAASKKC" Anti-E. coli, activity value is MIC = 3.5 ug/ml||Anti-S. aureus, activity value is MIC = 3.5 ug/ml||Anti-B. subtilis, activity value is MIC = 1.8 ug/ml||Anti-and C. albicans, activity value is MIC = 1.8 ug/ml||Anti-E. coli, activity value is MIC = 10.4 ug/ml||Anti-S. aureus, activity value is MIC = 20.8 ug/ml||Anti-and C. albicans, activity value is MIC = 10.4 uM||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 3.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3.5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 1.75 ug/ml||Anti-B. subtilis, activity value is MIC = 1.75 ug/ml||Anti-C. albicans, activity value is MIC = 1.75 ug/ml||Anti-Gram+ & Gram-||candidacidal||Hemolytic Odorrana grahami (2007); Huia schmackeri (formerly Odorrana schmackeri) (2008); Odorrana andersonii, China (2011), Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (2007); Huia schmackeri (formerly Odorrana schmackeri) (2008); Odorrana andersonii, China (2011), Asia|||Odorrana grahami (2007); Huia schmackeri (formerly Odorrana schmackeri) (2008); Odorrana andersonii, China (2011), Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||E. coli ( MIC = 3.5 ug/ml), S. aureus ( MIC = 3.5 ug/ml), B. subtilis ( MIC = 1.75 ug/ml), C. albicans ( MIC = 1.75 ug/ml)|||The document clearly provides hemolytic data for various antimicrobial peptides derived from the skin secretions of Graham's odorous frog (Odorrana grahami), with the core results as follows: All peptides were tested at a concentration of 50 µg/ml, using human red blood cells as the test subjects, and Triton X-100 as the positive control, which showed a hemolysis rate of 100%. Among them, Odorranain-A1 had a hemolysis rate of 14.2±5.6%, Odorranain-F1 7.3%, Odorranain-K1 18.3±4.6%, and Odorranain-U1 5.2±2.3%, all classified as low hemolytic activity. The remaining tested peptides, including Odorranain-B1, Odorranain-C1, and Odorranain-D1, showed no hemolytic activity (NA), and no red blood cell lysis was detected.|||11.2% hemolysis at 50 ug/ml." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 24 FPDB02307 AP01304|||OdP2a|||DRAMP01387|||OdP2a|||AP01304|||DRAMP01387|||AP01304 " GLLSGILGAGKHIVCGLSGPCQSLNRKSSDVEYHLAKC" Anti-E. coli, activity value is MIC = 6.3 ug/ml||Anti-S. aureus, activity value is MIC = 3.1 ug/ml||Anti-B. subtilis, activity value is MIC = 12.5 ug/ml||Anti-and C. albicans, activity value is MIC = 3.1 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3.12 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 12.5 ug/ml||Anti-Candida albicans, activity value is MIC = 3.12 ug/ml||Antimicrobial||Anti-Gram+||Anti-Gram-||Anti-Gram+ & Gram-||candidacidal skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||skin, Odorrana grahami, China, Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-894.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 38 FPDB02308 AP01305|||CAMPSQ712|||DRAMP01389|||OdS1|||AP01305|||AP01305 " FLPPSPWKETFRTS" Anti-E. coli, activity value is MIC = 42.5 ug/ml||Anti-S. aureus, activity value is MIC = 21.3 ug/ml||Anti-B. subtilis, activity value is MIC = 85 ug/ml||Anti-and C. albicans, activity value is MIC = 21.3 ug/ml||Anti-Escherichia Coli, activity value is MIC = 42.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 21.25 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 85 ug/ml||Anti-Candida albicans, activity value is MIC = 21.25 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||skin, Odorrana grahami, China, Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||In Document 1 (Eur. J. Biochem. 1994), various peptides of the dermaseptin family (including DS I, DS II-V, and adenoregulin/DS bII) showed no significant hemolytic activity. When tested on rabbit red blood cells, no hemolysis was observed even at the highest test concentration of 250 µg/ml." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 14 FPDB02309 AP01306|||Odorranain-T1|||DRAMP01390|||Odorranain-T1|||AP01306|||AP01306 " TSRCYIGYRRKVVCS" Anti-E. coli, activity value is MIC = 17.5 ug/ml||Anti-S. aureus, activity value is MIC = 35 ug/ml||Anti-B. subtilis, activity value is MIC = 17.5 ug/ml||Anti-and C. albicans, activity value is MIC = 8.8 ug/ml||Anti-Escherichia coli, activity value is MIC = 17.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 35 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 17.5 ug/ml||Anti-Candida albicans, activity value is MIC = 8.75 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal skin, Odorrana grahami, China, Asia|||Odorrana grahami|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||skin, Odorrana grahami, China, Asia Helix "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||In Document 1 (Eur. J. Biochem. 1994), various peptides of the dermaseptin family (including DS I, DS II-V, and adenoregulin/DS bII) showed no significant hemolytic activity. When tested on rabbit red blood cells, no hemolysis was observed even at the highest test concentration of 250 µg/ml." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 15 FPDB02310 AP01307|||Odorranain-U1 antimicrobial peptide|||DRAMP01391|||Odorranain-U1 antimicrobial peptide|||AP01307|||DRAMP01391|||AP01307 " GCSRWIIGIHGQICRD" Anti-E.coli, activity value is MIC > 100 uM||Anti-S. aureus, activity value is MIC = 75 ug/ml||Anti-B. subtilis, activity value is MIC = 9.4 ug/ml||Anti-and C. albicans, activity value is MIC = 9.4 ug/ml||Anti-Escherichia Coli, activity value is MIC > 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 75 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 9.37 ug/ml||Anti-Candida albicans, activity value is MIC = 9.37 ug/ml||Antibacterial||Antifungal||Anti-Gram+||candidacidal skin, Odorrana grahami, China, Asia|||Odorrana grahami|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||skin, Odorrana grahami, China, Asia Helix "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%." . 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Ref.17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 16 FPDB02311 AP01308|||CAMPSQ3155|||DRAMP01392|||Odorranain-V1|||AP01308|||AP01308 " GLLSGTSVRGSI" Anti-E. coli, activity value is MIC = 36 ug/ml||Anti-S. aureus, activity value is MIC = 18 ug/ml||Anti-B. subtilis, activity value is MIC = 18 ug/ml||Anti-and C. albicans, activity value is MIC = 9 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 36 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 18 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 18 ug/ml||Anti-Gram+ & Gram-||candidacidal||Hemolytic skin, Odorrana grahami, China, Asia|||Synthetic construct|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||skin, Odorrana grahami, China, Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 12 FPDB02312 AP01309 GLFGKSSVVGRKYYVDLAGCAKA Anti-E. coli, activity value is MIC = 12.6 ug/ml||Anti-S. aureus, activity value is MIC = 6.3 ug/ml||Anti-B. subtilis, activity value is MIC = 6.3 ug/ml||Anti-and C. albicans, activity value is MIC = 3.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic skin, Odorrana grahami, China, Asia|||skin, Odorrana grahami, China, Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 23 FPDB02313 AP01311|||Nigrocin-OG5|||DRAMP01421|||Nigrocin-OG5|||AP01311|||DRAMP01421|||AP01311 " GLLSGILGAGKQKVCGLSGLC" Anti-E. coli, activity value is MIC = 9.4 ug/ml||Anti-S. aureus, activity value is MIC = 18.8 ug/ml||Anti-B. subtilis, activity value is MIC = 37.5 ug/ml||Anti-and C. albicans, activity value is MIC = 4.7 ug/ml||Anti-E. coli, activity value is MIC = 9.37 ug/ml||Anti-S. aureus, activity value is MIC = 18.75 ug/ml||Anti-C. albicans, activity value is MIC = 4.68 ug/ml||Anti-Escherichia coli, activity value is MIC = 9.37 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 18.75 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 37.5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog)|||skin, Odorrana grahami, China, Asia|||Odorrana grahami (Yunnanfu frog)|||skin, Odorrana grahami, China, Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%.|||At a concentration of 50 µg/ml, the hemolysis rate of Odorranain-A1 was 12.7%, Odorranain-F1 was 15.4%, Odorranain-H1 was 21.6%, Odorranain-L1 was 18.3%, Odorranain-M1 was 8.2%, Odorranain-P1a was 11.2%, Odorranain-P2a was 15.2%, Odorranain-Q1 was 22.9%, Odorranain-V1 was 23.9%, Odorranain-W1 was 17.6%, Nigrocin-OG2 was 60.0%, Nigrocin-OG4 was 65.5%, Nigrocin-OG5 was 87.2%, Nigrocin-OG21 was 100%.|||[Ref.17272268] RCH=87.2 ± 2.6% against rabbit red blood cells at 50 ug/ml. RCH, red cell hemolysis.|||[Ref.17272268] RCH=87.2 ± 2.6% against rabbit red blood cells at 50 ug/ml. RCH, red cell hemolysis." "2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Gram-negative bacterium: Escherichia coli (MIC=9.37 ug/ml); Gram-positive bacteria: Staphylococcus aureus (MIC=18.75 ug/ml), Bacillus subtilis (MIC=37.5 ug/ml). Yeast: Candida albicans (MIC=4.68 ug/ml).|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med." 21 FPDB02314 AP01312|||Nigrocin-OG13|||Nigrocin-OG13|||AP01312|||AP01312 " GLLSGILGAGKHIVCGLSGLK" Anti-E. coli, activity value is MIC = 4.7 ug/ml||Anti-S. aureus, activity value is MIC = 4.7 ug/ml||Anti-B. subtilis, activity value is MIC = 18.8 ug/ml||Anti-and C. albicans, activity value is MIC = 1.1 ug/ml||Anti-Escherichia coli, activity value is MIC = 4.68 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 9.37 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 18.75 ug/ml||Anti-Candida albicans, activity value is MIC = 1.1 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 21 FPDB02315 AP01313 " GFFLNALKNFAKTAGKRLKSLLNHASCKLSGQC" Anti-Gram- E. coli, activity value is MIC = 5 ug/ml||Anti-K. pneumoniae PTCC1388, activity value is MIC = 10 ug/ml||Anti-B. cereus PTCC1247, activity value is MIC = 7 ug/ml||Anti-and S. aureus PTCC1431, activity value is MIC = 12 ug/ml||Anti-Gram+||Antifungal||candidacidal skin secretions, Euphlyctis cyanophlyctis, Asia|||skin secretions, Euphlyctis cyanophlyctis, Asia N/A The document mentions that at a high concentration of 500 μg/ml, the hemolysis rate of brevinin-Eu is 1.9%, and the hemolysis rate of cyanophlyctin β is 0.7%. 2014 Apr;83(4):411-7. doi: 10.1111/cbdd.12256|||Chem Biol Drug Des. 2014 Apr;83(4):411-7. doi: 10.1111/cbdd.12256. Pub-Med. 33 FPDB02316 AP01314|||Nigrocin-OG21|||DRAMP01425|||Nigrocin-OG21|||AP01314|||DRAMP01425|||AP01314 " GLLSGVLGVGKKVDCGLSGLC" Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anti-Escherichia coli, activity value is MIC = 4.68 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 9.37 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 18.75 ug/ml||Anti-Candida albicans, activity value is MIC = 4.68 ug/ml||Antimicrobial||Antibacterial||Antifunga skin, Odorrana grahami, China, Asia|||Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog)|||skin, Odorrana grahami, China, Asia|||Odorrana grahami (Yunnanfu frog)|||skin, Odorrana grahami, China, Asia N/A "The document mentions the hemolytic values of certain peptides on human red blood cells, as follows: odorranain-A1: Hemolysis rate (RCH) is 12.7%. odorranain-B1: No obvious hemolysis. odorranain-C1: No obvious hemolysis. odorranain-D1: No obvious hemolysis. odorranain-E1: Hemolysis rate is -12% (inhibition of hemolysis). odorranain-F1: No obvious hemolysis. odorranain-G1: No obvious hemolysis. odorranain-H1: Hemolysis rate is 25.6%. odorranain-I1: No obvious hemolysis. odorranain-J1: No obvious hemolysis. odorranain-K1: Hemolysis rate is -11% (inhibition of hemolysis). odorranain-L1: Hemolysis rate is 22.4%. odorranain-M1: Hemolysis rate is 8.2%. odorranain-N1: No obvious hemolysis. odorranain-O1: No obvious hemolysis. odorranain-P1a: No obvious hemolysis. odorranain-P2a: Hemolysis rate is 20.7%. odorranain-Q1: Hemolysis rate is 23.6%. odorranain-R1: No obvious hemolysis. odorranain-S1: No obvious hemolysis. odorranain-T1: No obvious hemolysis. odorranain-U1: Hemolysis rate is 5.2%. odorranain-V1: No obvious hemolysis. odorranain-W1: No obvious hemolysis. nigrocin-OG2: Hemolysis rate is 18.1%. nigrocin-OG4: Hemolysis rate is 22.3%. nigrocin-OG5: Hemolysis rate is 14.0%. nigrocin-OG13: No obvious hemolysis. nigrocin-OG20: No obvious hemolysis. nigrocin-OG21: Hemolysis rate is 17.0%. Note: ""NA"" in the table indicates that hemolytic activity was not detected, and some negative values indicate inhibition of hemolysis. In the hemolysis experiment, Triton X-100 was used as a positive control, with a hemolysis rate of 100%." 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-894.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 21 FPDB02327 AP01339|||BHP|||AP01339|||DRAMP02827 FLSFPTTKTYFPHFDLSHGSAQVKGHGAK Anti-Gram+||Antifungal||candidacidal||Micrococcus luteus strain A270||No MICs found in DRAMP database||Antimicrobial the tick Boophilus microplus|||Bos taurus [Bovine]|||the tick Boophilus microplus|||Bos taurus (Bovine) N/A "The document mentions the following hemolysis-related values: ascaphin-8: The half-lethal concentration (LC₅₀) for human red blood cells is 55 µM. Its analogs with amino acid substitutions (Ala¹⁰, Val¹⁴, and Leu¹⁸ replaced with L-Lys or D-Lys) show significantly reduced toxicity to human red blood cells, HepG2 liver cancer cells, and L929 fibroblasts (more than 10 times lower). brevinin-1BYa: The half-lethal concentration (LD₅₀) for human red blood cells is 10 µM. The cyclic-free analog obtained by replacing cysteine with serine shows an 8-fold reduction in hemolytic activity, while maintaining high efficacy against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) (MIC = 5 µM). temporin-DRa: The half-lethal concentration (LD₅₀) for human red blood cells is 70 µM. Analogues with replacements (Val⁷→L-Lys), (Thr⁵→D-Lys), and (Asn⁸→D-Lys) show a 10-fold reduction in hemolytic activity; replacing Ile¹³ with α-aminoisobutyric acid (Aib) increases the therapeutic index (the ratio of red blood cell LC₅₀ to microbial MIC) by 4 times.|||The therapeutic potential of temporin-DRa is restricted by its significant hemolytic activity against human erythrocytes (LD50=70 uM). A structure-activity study has demonstrated that analogs containing the substitutions (Val7 → L-Lys), (Thr5 → D-Lys) and (Asn8 → D-Lys) retained the high solubility and potent, broad spectrum antimicrobial activity of the naturally occurring peptide but were appreciably (up to 10-fold) less hemolytic [44]." 2009 Aug;1788(8):1556-63. doi: 10.1016/j.bbamem.2008.09.018. Epub 2008 Oct 17.|||11226440|||J Biol Chem. 1999 Sep 3;274(36):25330-4. Pub-Med.|||J Appl Microbiol. 2009 Jan;106(1):233-240. 29 FPDB02330 AP01345|||Brevinin-1LTa|||DRAMP01988|||Brevinin-1LTa|||AP01345|||DRAMP01988|||AP01345 FFGTALKIAANVLPTAICKILKKC Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Antibacterial||Antimicrobial||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 10 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 6 ug/ml||Anti-Pseudomonas fluorescens ATCC13525, activity value is MIC = 80 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 50 ug/ml Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae), China, Asia|||Hylarana latouchii [Broad-folded frog]|||Hylarana latouchii (Chinese frog fauna)|||Hylarana latouchii [Broad-folded frog]|||Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae), China, Asia|||Hylarana latouchii (Chinese frog fauna)|||Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae), China, Asia N/A the novel|||Staphylococcus aureus ATCC2592 ( MIC = 10 ug/ml ), Bacillus subtilis ATCC6633 ( MIC = 6 ug/ml ), Pseudomonas fluorescens ATCC13525 ( MIC = 80 ug/ml ), Candida albicans ATCC2002 ( MIC = 50 ug/ml )|||Rabbit erythrocytes ( LD50 = 1.5 ug/ml )|||In this study, we used rabbit red blood cells to examine the hemolytic capability (Table 3). It was observed that both brevinin-1LTa (LD50 = 1500 ug/ml) and temporin-LTa (LD50 =9000 ug/ml) had a strong hemolytic activity against rabbit red blood cells. In contrast, temporin-LTb and temporin-LTc had little hemolytic activity even with peptide concentrations up to 200000 ug/ml. 2009 Feb;30(2):273-82. doi: 10.1016/j.peptides.2008.10.016. Epub 2008 Nov 5.|||19022312|||Peptides. 2009 Feb;30(2):273-282.|||19022312|||Peptides. 2009 Feb;30(2):273-82. Pub-Med.|||Peptides. 2009 Feb;30(2):273-282.|||Peptides. 2009 Feb;30(2):273-82. Pub-Med. 24 FPDB02345 AP01364|||Defensin|||DRAMP03162|||Defensin|||AP01364|||AP01364 ATCDLLSAFGVGHAACAAHCIGHGYRGGYCNSKAVCTCRR Anti-Gram+||Antifungal||candidacidal||Antiparasitic||Antibacterial||Antimicrobial||Anti-S. aureus, activity value is MIC = 0.78||Anti-Aspergillus fumigatus, activity value is MIC = 12.5||Anti-F. culmorum, activity value is MIC = 1.56||Anti-F. oxysporum, activity value is MIC = 3.12||Anti-Neurospora crassa, activity value is MIC = 6.25||Anti-T. viride, activity value is MIC = 3.12||Anti-Trichophyton mentagrophytes, activity value is MIC = 25||Anti-Candida albicans, activity value is MIC = 6.25||Anti-S. cerevisiae, activity value is MIC = 25||Anti-L. major promastigote forms, activity value is IC50 = 68 Phlebotomus duboscqi|||Phlebotomus duboscqi [Sandfly]|||Phlebotomus duboscqi Bridge N/A Infect Immun. 2004 Dec;72(12):7140-6|||15557638|||Infect Immun. 2004 Dec;72(12):7140-7146.|||15557638|||Infect Immun. 2004 Dec;72(12):7140-6|||Infect Immun. 2004 Dec;72(12):7140-6 40 FPDB02355 AP01378|||Paneth cell-specific alpha-defensin 1|||AP01378 SCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial Paneth cells; Equus caballus|||Equus caballus [horse ]|||Paneth cells; Equus caballus|||Paneth cells; Equus caballus Beta N/A 2007 Oct 15;407(2):267-76. doi: 10.1042/BJ20070747.|||17620056|||Biochem J. 2007 Oct 15;407(2):267-76. PubMed.|||Biochem J. 2007 Oct 15;407(2):267-76. PubMed. 34 FPDB02392 AP01436|||Brevinin-1AUa|||DRAMP02034|||Brevinin-1AUa|||AP01436|||AP01436 FLPILAGLAAKLVPKVFCSITKKC Anti-E. coli, activity value is MIC = 13 uM||Anti-K. pneumoniae, activity value is MIC = 50 uM||Anti-S. aureus, activity value is MIC = 3 uM||Anti-C. albicans, activity value is MIC = 3 uM||Anti-and P.mirabilis, activity value is MIC > 50 uM||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 13 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 25 uM||Anti-Enterobacter cloacae, activity value is MIC = 13 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 50 uM||Anti-Proteus mirabilis, activity value is MIC > 50 uM||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 6 uM||Anti-Enterococcus faecalis, activity value is MIC = 13 uM||Anti-Streptococcus Group B, activity value is MIC = 13 uM||Anti-Candida albicans, activity value is MIC > 40 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 25 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 6 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 13 uM||Anti-Streptococcus Group B HNTCC80130, activity value is MIC = 13 uM||Anti-Enterobacter cloacae NHTCC 53001, activity value is MIC = 13 uM||Anti-Klebsiella pneumoniae KK3 9904, activity value is MIC = 50 uM||Anti-Proteus mirabilis ATCC 25933, activity value is MIC > 50 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 3 uM||Anti-Gram+ & Gram-||candidacidal||Hemolytic the Northern red-legged frog, Rana aurora aurora, North America|||Rana aurora aurora [Northern red-legged frog]|||Rana aurora aurora (Northern red-legged frog)|||Rana aurora aurora [Northern red-legged frog]|||the Northern red-legged frog, Rana aurora aurora, North America|||the Northern red-legged frog, Rana aurora aurora, North America N/A The document mentions the following values related to hemolytic activity: ranatuerin-2AUa: half-maximal hemolytic concentration (HC₅₀) for human red blood cells is 290 µM. brevinin-1AUa: HC₅₀ for human red blood cells is 5 µM. brevinin-1AUb: HC₅₀ for human red blood cells is 7 µM. temporin-1AUa: HC₅₀ for human red blood cells is greater than 300 µM.|||Escherichia coli ( MIC = 13 uM ), Pseudomonas aeruginosa ATCC 27853 ( MIC = 25 uM ), Staphylococcus aureus ( MIC = 3 uM ), Staphylococcus epidermidis RP62A ( MIC = 6 uM ), Enterococcus faecalis ATCC 29212 ( MIC = 13 uM ), Streptococcus Group B HNTCC80130 ( MIC = 13 uM ) , Enterobacter cloacae NHTCC 53001 ( MIC = 13 uM ), Klebsiella pneumoniae KK3 9904 ( MIC = 50 uM ), Proteus mirabilis ATCC 25933 ( MIC > 50 uM ), Candida albicans ATCC 90028 ( MIC = 3 uM )|||(Developmental and Comparative Immunology 2005), among the antimicrobial peptides isolated from the skin secretions of the northern red-legged frog (Rana aurora aurora), ranatuerin-2AUa has a HCthe for human erythrocytes of 290 uM,brevinin-1AUa has a HCthe for human erythrocytes of 5 uM,brevinin-1AUb has a HCthe for human erythrocytes of 7 uM, and temporin-1AUa has a HCthe for human erythrocytes of greater than 300 uM.|||[Ref.15325526] HC50=5 uM against human erythrocytes|||Human erythrocytes ( HC50 = 5 uM ) 2005;29(1):83-90. doi: 10.1016/j.dci.2004.05.003.|||15325526|||Dev Comp Immunol. 2005;29(1):83-90.||Ref.15325526|||15325526||Ref.15325526|||15325526|||Dev Comp Immunol. 2005;29(1):83-90. PubMed|||Dev Comp Immunol. 2005;29(1):83-90. PubMed 24 FPDB02393 AP01437|||Brevinin-1AUb|||DRAMP02035|||Brevinin-1AUb|||AP01437|||AP01437 FLPILAGLAANILPKVFCSITKKC Anti-E. coli, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 3 uM||Anti-C. albicans, activity value is MIC = 3 uM||Anti-K.pneumoniae, activity value is MIC > 50 uM||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 25 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 25 uM||Anti-Enterobacter cloacae, activity value is MIC = 25 uM||Anti-Klebsiella pneumoniae, activity value is MIC > 50 uM||Anti-Proteus mirabilis, activity value is MIC > 50 uM||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 6 uM||Anti-Enterococcus faecalis, activity value is MIC = 6 uM||Anti-Streptococcus Group B, activity value is MIC = 13 uM||Anti-Candida albicans, activity value is MIC = 3 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 25 uM||Anti-Staphylococcus epidermidis RP62A, activity value is MIC = 6 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 6 uM||Anti-Streptococcus Group B HNTCC80130, activity value is MIC = 13 uM||Anti-Enterobacter cloacae NHTCC 53001, activity value is MIC = 25 uM||Anti-Klebsiella pneumoniae KK3 9904, activity value is MIC > 50 uM||Anti-Proteus mirabilis ATCC 25933, activity value is MIC > 50 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 3 uM||Anti-Gram+ & Gram-||candidacidal||Hemolytic the Northern red-legged frog, Rana aurora aurora, North America|||Rana aurora aurora [Northern red-legged frog]|||Rana aurora aurora (Northern red-legged frog)|||Rana aurora aurora [Northern red-legged frog]|||the Northern red-legged frog, Rana aurora aurora, North America|||the Northern red-legged frog, Rana aurora aurora, North America N/A The document mentions the following values related to hemolytic activity: ranatuerin-2AUa: half-maximal hemolytic concentration (HC₅₀) for human red blood cells is 290 µM. brevinin-1AUa: HC₅₀ for human red blood cells is 5 µM. brevinin-1AUb: HC₅₀ for human red blood cells is 7 µM. temporin-1AUa: HC₅₀ for human red blood cells is greater than 300 µM.|||Human erythrocytes ( HC50 = 7 uM )|||(Developmental and Comparative Immunology 2005), among the antimicrobial peptides isolated from the skin secretions of the northern red-legged frog (Rana aurora aurora), ranatuerin-2AUa has a HCthe for human erythrocytes of 290 uM,brevinin-1AUa has a HCthe for human erythrocytes of 5 uM,brevinin-1AUb has a HCthe for human erythrocytes of 7 uM, and temporin-1AUa has a HCthe for human erythrocytes of greater than 300 uM.|||[Ref.15325526] HC50=7 uM against human erythrocytes|||Human erythrocytes ( HC50 = 7 uM ) 2005;29(1):83-90. doi: 10.1016/j.dci.2004.05.003.|||15325526|||Dev Comp Immunol. 2005;29(1):83-90.||Ref.15325526|||15325526||Ref.15325526|||15325526|||Dev Comp Immunol. 2005;29(1):83-90. PubMed|||Dev Comp Immunol. 2005;29(1):83-90. PubMed 24 FPDB02394 AP01438|||Brevinin-1SPa|||DRAMP01869|||Brevinin-1SPa|||AP01438|||DRAMP01869|||AP01438 FFPIIAGMAAKLIPSLFCKITKKC Anti-and C. albicans, activity value is MIC = 3||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 13 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Candida albicans, activity value is MIC = 7 uM||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Candida albicans, activity value is MIC = 6 uM||Anti-Gram+ & Gram-||candidacidal||Hemolytic Rana septentrionalis , North America|||Rana septentrionalis [Mink frog]|||Rana septentrionalis (mink frog)|||Rana septentrionalis [Mink frog]|||Rana septentrionalis , North America|||Rana septentrionalis (mink frog)|||Rana septentrionalis , North America N/A The document mentions the following hemolytic-related values: brevinin-1SPa: half-maximal hemolytic concentration (HC₅₀) on human red blood cells is 7 µM. brevinin-1SPb: HC₅₀ on human red blood cells is 25 µM. brevinin-1SPd: HC₅₀ on human red blood cells is 8 µM. temporin-1SPb: HC₅₀ on human red blood cells is 60 µM. brevinin-2 related peptides: HC₅₀ on human red blood cells is 70 µM.|||Human erythrocytes ( HC50 = 7 uM )|||In Document 2 (Comparative Biochemistry and Physiology, Part C 2004), among the antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), brevinin-1SPa has an HC₅₀ of 7 μM for human red blood cells, brevinin-1SPb has an HC₅₀ of 25 μM, brevinin-1SPd has an HC₅₀ of 8 μM, temporin-1SPb has an HC₅₀ of 60 μM, and brevinin-2 related peptide has an HC₅₀ of 70 μM.|||[Ref.15556063]HC50=7 uM against human erythrocytes|||Human erythrocytes ( HC50 = 7 uM )|||[Ref.15556063]HC50=7 uM against human erythrocytes 2004 Oct;139(1-3):31-8. doi: 10.1016/j.cca.2004.08.019.|||15556063|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.||Ref.15556063|||15556063||Ref.15556063|||15556063|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-8. PubMed|||Ref.15556063|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-8. PubMed 24 FPDB02395 AP01439|||DRAMP01870|||AP01439|||DRAMP01870 FLPIIAGMAAKVICAITKKC Anti-E. coli, activity value is MIC = 50 uM||Anti-S. aureus, activity value is MIC = 6 uM||Anti-and C. albicans, activity value is MIC = 13 uM||Anti-Escherichia coli, activity value is MIC = 50 uM||Anti-Staphylococcus aureus, activity value is MIC = 13 uM||Anti-Candida albicans, activity value is MIC = 25 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic Rana septentrionalis , North America|||Rana septentrionalis (mink frog)|||Rana septentrionalis , North America|||Rana septentrionalis (mink frog)|||Rana septentrionalis , North America N/A The document mentions the following hemolytic-related values: brevinin-1SPa: half-maximal hemolytic concentration (HC₅₀) on human red blood cells is 7 µM. brevinin-1SPb: HC₅₀ on human red blood cells is 25 µM. brevinin-1SPd: HC₅₀ on human red blood cells is 8 µM. temporin-1SPb: HC₅₀ on human red blood cells is 60 µM. brevinin-2 related peptides: HC₅₀ on human red blood cells is 70 µM.|||In Document 2 (Comparative Biochemistry and Physiology, Part C 2004), among the antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), brevinin-1SPa has an HC₅₀ of 7 μM for human red blood cells, brevinin-1SPb has an HC₅₀ of 25 μM, brevinin-1SPd has an HC₅₀ of 8 μM, temporin-1SPb has an HC₅₀ of 60 μM, and brevinin-2 related peptide has an HC₅₀ of 70 μM.|||[Ref.15556063]HC50=25 uM against human erythrocytes|||[Ref.15556063]HC50=25 uM against human erythrocytes 2004 Oct;139(1-3):31-8. doi: 10.1016/j.cca.2004.08.019.|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.||Ref.15556063|||15556063||Ref.15556063|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-8. PubMed|||Ref.15556063|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-8. PubMed 20 FPDB02396 AP01440|||DRAMP01872|||AP01440|||DRAMP01872 FFPIIAGMAAKVICAITKKC Anti-E. coli, activity value is MIC = 13 uM||Anti-S. aureus, activity value is MIC = 3 uM||Anti-and C. albicans, activity value is MIC = 3 uM||Anti-Escherichia coli, activity value is MIC = 13 uM||Anti-Staphylococcus aureus, activity value is MIC = 3 uM||Anti-Candida albicans, activity value is MIC = 8 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic Rana septentrionalis , North America|||Rana septentrionalis (mink frog)|||Rana septentrionalis , North America|||Rana septentrionalis (mink frog)|||Rana septentrionalis , North America N/A The document mentions the following hemolytic-related values: brevinin-1SPa: half-maximal hemolytic concentration (HC₅₀) on human red blood cells is 7 µM. brevinin-1SPb: HC₅₀ on human red blood cells is 25 µM. brevinin-1SPd: HC₅₀ on human red blood cells is 8 µM. temporin-1SPb: HC₅₀ on human red blood cells is 60 µM. brevinin-2 related peptides: HC₅₀ on human red blood cells is 70 µM.|||In Document 2 (Comparative Biochemistry and Physiology, Part C 2004), among the antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), brevinin-1SPa has an HC₅₀ of 7 μM for human red blood cells, brevinin-1SPb has an HC₅₀ of 25 μM, brevinin-1SPd has an HC₅₀ of 8 μM, temporin-1SPb has an HC₅₀ of 60 μM, and brevinin-2 related peptide has an HC₅₀ of 70 μM.|||[Ref.15556063]HC50=8 uM against human erythrocytes|||[Ref.15556063]HC50=8 uM against human erythrocytes 2004 Oct;139(1-3):31-8. doi: 10.1016/j.cca.2004.08.019.|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.||Ref.15556063|||15556063||Ref.15556063|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-8. PubMed|||Ref.15556063|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-8. PubMed 20 FPDB02397 AP01445 FMGSALRIAAKVLPAALCQIFKKC Anti-Gram+ S. aureus ATCC2592, activity value is MIC = 6.25 ug/ml||Anti-B. subtilis ATCC6633, activity value is MIC = 6.25 ug/ml||Anti-P. fluorescens ATCC13525, activity value is MIC = 100 ug/ml||Anti-and fungus C. albicans ATCC2002, activity value is MIC = 50 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Hylarana latouchii , Asia|||Hylarana latouchii , Asia Helix In this study, we used rabbit red blood cells to examine the hemolytic capability, and the results were shown in Table 2.Itwas observed that all of the antimicrobial peptides found in this work had low hemolytic activity against rabbit red blood cells. 2009 Apr;91(4):540-7. doi: 10.1016/j.biochi.2009.01.007.|||Biochimie. 2009 Apr;91(4):540-7. Pub-Med. 24 FPDB02414 AP01471|||Substance P|||SP|||DRAMP18693|||Substance P|||SP|||AP01471|||DRAMP18693|||AP01471 RPKPQQFFGLM Anti-It showed a good activity against E. coli ATCC 25922, activity value is MIC = 5.7 ug/ml||Anti-and C. albicans, activity value is MIC = 8 ug/ml||Anti-weak activity against L acidophilus NCTC 1723, activity value is MIC = 74 ug/ml||Anti-and very weak activity against S. mutans NCTC 10449, activity value is MIC = 171 ug/ml||Staphylococcus aureus||Candida albicans||S. aureus||E. coli||E. faecalis||P. vulgaris||P. aeruginosa||C. albicans||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||Antifungal ; N.A||Anti-Escherichia coli, activity value is MIC = 0.06 %||Anti-Proteus vulgaris, activity value is MIC = 0.13 %||Anti-Pseudomonas aeruginosa, activity value is MIC = 0.13 %||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 0.007 %||Anti-Enterococcus faecalis, activity value is MIC = 0.13 %||Anti-##Yeast: Candida albicans, activity value is MIC = 0.25 %||Anti-Gram+ & Gram-||candidacidal Homo sapiens|||Synthetic construct|||Homo sapiens Helix No hemolysis information or data found in the reference(s) presented in this entry Life Sci. 2002 Jul 5;71(7):747-50||Gayen A et al 2011 Biochim Biophys Acta 1808:127-139|||12074933|||Life Sci. 2002 Jul 5;71(7):747-50.|||https://pubmed.ncbi.nlm.nih.gov/12074933|||Life Sci. 2002 Jul 5;71(7):747-50||Gayen A et al 2011 Biochim Biophys Acta 1808:127-139|||Life Sci. 2002 Jul 5;71(7):747-50.||Ref.12074933|||Life Sci. 2002 Jul 5;71(7):747-50 11 FPDB02417 AP01474|||Neuropeptide Y|||AP01474|||DRAMP04254 YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Candida albicans, activity value is MIC = 10||Antimicrobial||Antibacterial brain, Homo sapiens|||Homo sapiens [Human]|||brain, Homo sapiens|||Synthetic construct|||brain, Homo sapiens Helix N/A Antimicrob Agents Chemother. 1998 Oct;42(10):2745-6|||9756788|||Antimicrob Agents Chemother. 1998 Oct;42(10):2745-6|||Antimicrob Agents Chemother. 1998 Oct;42(10):2745-2746. 36 FPDB02418 AP01476|||Calcitonin gene-related peptide|||AP01476 ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF Anti-It showed a good activity against E. coli ATCC 25922, activity value is MIC = 2.1 ug/ml||Anti-moderate activity against C. albicans NCTC 3179, activity value is MIC = 63 ug/ml||Antibacterial||Antifungal||Anti-Gram-||candidacidal Homo sapiens|||Homo sapiens [Human]|||Homo sapiens Helix N/A J Neuroimmunol. 2008 Aug 30;200(1-2):11-6|||18603306|||J Neuroimmunol. 2008 Aug 30;200(1-2):11-6 37 FPDB02419 AP01477|||Vasoactive intestinal polypeptide|||Vasoactive intestinal polypeptide|||AP01477|||AP01477 HSDAVFTDNYTRLRKQMAVKKYLNSILN Anti-Gram+ & Gram-||Antifungal||candidacidal||Streptococcus mutans||Lactobacillus acidophilus||Enterococcus faecalis||Escherichia coli||Staphylococcus aureus||Pseudomonas aeruginosa||Candida albicans||Antibacterial Homo sapiens|||Homo sapiens [Human]|||Homo sapiens [Human]|||Homo sapiens|||Homo sapiens N/A N/A J Neuroimmunol. 2008 Aug 30;200(1-2):11-6|||18603306|||18603306|||J Neuroimmunol. 2008 Aug 30;200(1-2):11-6|||J Neuroimmunol. 2008 Aug 30;200(1-2):11-6 28 FPDB02421 AP01480|||DRAMP04530 LRQSQFVGSR Anti-Gram+ bacteria S. mutants, activity value is MIC = 21.3 uM||Anti-S. aureus, activity value is MIC = 42.5 uM||Anti-and E. faecium, activity value is MIC = 21.3 uM||Anti-P. aeruginosa, activity value is MIC = 21.3 uM||Anti-and V. vulnificus, activity value is MIC = 42.5 uM||Anti-T. beigelii, activity value is MIC = 21.3 uM||Anti-M. furfur, activity value is MIC = 42.5 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-Gram+ & Gram-||Antifungal||candidacidal edible fat innkeeper worm or the penis fish, Urechis unicinctus|||edible fat innkeeper worm or the penis fish, Urechis unicinctus|||Urechis unicinctus N/A "The document mentions the following values related to hemolysis: DEFB120: At concentrations up to 250 μg/ml, the hemolysis rate of human red blood cells is less than 10%, showing no significant hemolytic activity. LL37 (positive control): At a concentration of 250 μg/ml, the hemolysis rate of human red blood cells is approximately 35%." 2008 Jul 9;582(16):2463-6. doi: 10.1016/j.febslet.2008.06.015. Epub 2008 Jun 18.|||FEBS Lett. 2008 Jul 9;582(16):2463-6. Pub-Med.|||FEBS Lett. 2008 Jul 9;582(16):2463-2466. 10 FPDB02422 AP01481|||DRAMP04531 AAGMGFFGAR Anti-Gram+ bacteria S. mutants, activity value is MIC = 12.7 uM||Anti-S. aureus, activity value is MIC = 25.4 uM||Anti-and E. faecium, activity value is MIC = 25.4 uM||Anti-P. aeruginosa, activity value is MIC = 12.7 uM||Anti-and V. vulnificus, activity value is MIC = 25.4 uM||Anti-T. beigelii, activity value is MIC = 12.7 uM||Anti-M. furfur, activity value is MIC = 50.9 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-Gram+ & Gram-||Antifungal||candidacidal edible fat innkeeper worm or the penis fish, Urechis unicinctus|||edible fat innkeeper worm or the penis fish, Urechis unicinctus|||Urechis unicinctus N/A "The document mentions the following values related to hemolysis: DEFB120: At concentrations up to 250 μg/ml, the hemolysis rate of human red blood cells is less than 10%, showing no significant hemolytic activity. LL37 (positive control): At a concentration of 250 μg/ml, the hemolysis rate of human red blood cells is approximately 35%." 2008 Jul 9;582(16):2463-6. doi: 10.1016/j.febslet.2008.06.015. Epub 2008 Jun 18.|||FEBS Lett. 2008 Jul 9;582(16):2463-6. Pub-Med.|||FEBS Lett. 2008 Jul 9;582(16):2463-2466. 10 FPDB02426 AP01496|||Temporin-CPa|||Temporin-CPa|||AP01496|||DRAMP01785|||AP01496 IPPFIKKVLTTVF Anti-E. coli, activity value is MIC = 25 uM||Anti-it is also active against S. epidermidis, activity value is MIC = 12.5 uM||Anti-B. subtilis, activity value is MIC = 50 uM||Anti-K. pneumoniae, activity value is MIC = 50 uM||Anti-G. Glabrata, activity value is MIC = 12.5 uM||Anti-and C. tropicalis, activity value is MIC = 3.1||Anti-Staphylococcus aureus USA300, activity value is MIC = 25 uM||Anti-Staphylococcus epidermidis 1457, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis 168, activity value is MIC = 50 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 12.5 uM||Anti-Klebsiella pneumoniae ATCC13883, activity value is MIC = 50 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 25 uM||Anti-C. glabrata ATCC 2001, activity value is MIC = 12.5 uM||Anti-C. tropicalis ATCC 13803, activity value is MIC = 3.1||Anti-Candida albicans, activity value is MIC = 25 uM||Anti-Staphylococcus aureus, activity value is MIC = 50 uM||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25726, activity value is MIC = 25 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 50 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 25 uM||Anti-Gram+ & Gram-||candidacidal the New World frog Lithobates capito, North America|||Rana capito [Florida gopher frog]|||Rana capito [Florida gopher frog]|||the New World frog Lithobates capito, North America|||Lithobates capito (New World frog)|||the New World frog Lithobates capito, North America N/A LC50=220 uM|||Human RBCs (HL50 = >100 uM)|||Human RBCs (HL50 = >100 uM)|||[Ref:19635516]LC50=220 uM against human erythrocytes "Peptides . 2009 Oct;30(10):1775-81. doi: 10.1016/j.peptides.2009.07.011. Epub 2009 Jul 25.|||19635516, 29842923||Refer PubMed ID: 29842923|||19635516, 29842923|||Peptides. 2009 Oct;30(10):1775-81. Pub-Med.|||Ref.19635516|||Peptides. 2009 Oct;30(10):1775-81. Pub-Med." 13 FPDB02428 AP01509|||Scolopin 1|||DRAMP02402|||Scolopin 1|||AP01509|||AP01509 FLPKMSTKLRVPYRRGTKDYH Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anti-Staphylococcus aureus ATCC2576, activity value is MIC = 1.2 ug/ml||Anti-Escherichia coli ATCC25629, activity value is MIC = 12.5 ug/ml||Anti-Bacillus dysenteriae ATCC2932, activity value is MIC = 7.5 ug/ml||Anti-Candida albicans ATCC3007, activity value is MIC = 15 ug/ml||Anti-Escherichia coli standard strain, activity value is MIC = 12.5 ug/ml||Anti-E. coli drug-resistant strain, activity value is MIC = 15 ug/ml||Anti-Staphylococcus aureus standard strain, activity value is MIC = 1.2 ug/ml||Anti-S. aureus drug-resistant strain, activity value is MIC = 5 ug/ml||Anti-Bacillus dysenteriae standard and drug-resistant strains, activity value is MIC = 7.5 ug/ml||Anti-Candida albicans, activity value is MIC = 15 ug/ml||Anti-E. coli ATCC25629, activity value is MIC = 12.5 ug/ml||Anti-resistant E. coli, activity value is MIC = 15||Anti-S. aureus ATCC2576, activity value is MIC = 1.2 ug/ml||Anti-resistant S. aureus, activity value is MIC = 5||Anti-normal ATCC293 and resistant B. dysenteriae, activity value is MIC = 7.5||Anti-and C. albicans ATCC 300, activity value is MIC = 15 ug/ml centipede venoms, Scolopendra subspinipes mutilans , China, Asia|||Scolopendra mutilans [Chinese red-headed centipede]|||Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans)|||centipede venoms, Scolopendra subspinipes mutilans , China, Asia|||centipede venoms, Scolopendra subspinipes mutilans , China, Asia N/A At a concentration of 50 μg/ml, scolopin 1 had a hemolysis rate of (25±2)% for human red blood cells and (21±5)% for rabbit red blood cells; scolopin 2 had a hemolysis rate of (32±7)% for human red blood cells and (37±6)% for rabbit red blood cells.|||Human erythrocytes ( Hemolysis = 25+/- 2 % ), Rabbit erythrocytes ( Hemolysis = 21+/- 5 % ) "Toxicon . 2010 Feb-Mar;55(2-3):274-9. doi: 10.1016/j.toxicon.2009.07.040. Epub 2009 Aug 28.|||19716842|||Toxicon. 2010 Feb-Mar;55(2-3):274-279||Ref.19716842|||19716842|||Toxicon. 2010 Feb-Mar;55(2-3):274-9. Pub-Med.|||Toxicon. 2010 Feb-Mar;55(2-3):274-9. Pub-Med." 21 FPDB02429 AP01510|||Scolopin 2|||DRAMP02403|||Scolopin 2|||AP01510|||AP01510 GILKKFMLHRGTKVYKMRTLSKRSH Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Anti-Staphylococcus aureus ATCC2576, activity value is MIC = 0.5 ug/ml||Anti-Escherichia coli ATCC25629, activity value is MIC = 5 ug/ml||Anti-Bacillus dysenteriae ATCC2932, activity value is MIC = 2.5 ug/ml||Anti-Candida albicans ATCC3007, activity value is MIC = 7.5 ug/ml||Anti-Escherichia coli standard and drug-resistant strains, activity value is MIC = 5 ug/ml||Anti-Staphylococcus aureus standard strain, activity value is MIC = 0.5 ug/ml||Anti-S. aureus drug-resistant strain, activity value is MIC = 1 ug/ml||Anti-Bacillus dysenteriae standard strain, activity value is MIC = 2.5 ug/ml||Anti-B. dysenteriae drug-resistant strain, activity value is MIC = 5 ug/ml||Anti-Candida albicans, activity value is MIC = 7.5 ug/ml||Anti-normal and resistant E. coli ATCC25629, activity value is MIC = 5 ug/ml||Anti-normal and resistant S. aureus ATCC2576, activity value is MIC = 0.5||Anti-normal and resistant B. dysenteriae ATCC 2932, activity value is MIC = 2.5||Anti-and C. albicans ATCC 3007, activity value is MIC = 7.5 ug/ml centipede venoms, Scolopendra subspinipes mutilans, China, Asia|||Scolopendra mutilans [Chinese red-headed centipede]|||Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans)|||Scolopendra mutilans [Chinese red-headed centipede]|||centipede venoms, Scolopendra subspinipes mutilans, China, Asia|||centipede venoms, Scolopendra subspinipes mutilans, China, Asia N/A At a concentration of 50 μg/ml, scolopin 1 had a hemolysis rate of (25±2)% for human red blood cells and (21±5)% for rabbit red blood cells; scolopin 2 had a hemolysis rate of (32±7)% for human red blood cells and (37±6)% for rabbit red blood cells.|||Human erythrocytes ( Hemolysis = 32+/- 7 % ), Rabbit erythrocytes ( Hemolysis = 37+/- 6 % )|||Human erythrocytes ( Hemolysis = 32+/- 7 % ), Rabbit erythrocytes ( Hemolysis = 37+/- 6 % )|||Human RBC: 32% hemolyis at 50 ug/ml. Rabbit RBC: 37% hemolyis at 50 ug/ml. "Toxicon . 2010 Feb-Mar;55(2-3):274-9. doi: 10.1016/j.toxicon.2009.07.040. Epub 2009 Aug 28.|||19716842|||Toxicon. 2010 Feb-Mar;55(2-3):274-279||Ref.19716842|||19716842|||Toxicon. 2010 Feb-Mar;55(2-3):274-9. Pub-Med.|||Toxicon. 2010 Feb-Mar;55(2-3):274-9. Pub-Med." 25 FPDB02455 AP01544|||Venom antimicrobial peptide-6|||DRAMP03750|||Venom antimicrobial peptide-6|||AP01544|||AP01544 IFGAIAGLLKNIF Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Antibacterial||Anti-Bacillus sp. DM-1, activity value is MIC = 2 uM||Anti-Micrococcus luteus, activity value is MIC = 2.9 uM||Anti-Bacillus megaterium, activity value is MIC = 0.25 uM||Anti-Agrobacterium tumefaciens, activity value is MIC = 11.8 uM||Anti-Escherichia coli, activity value is MIC = 7.9 uM||Anti-Shewanella oneidensis, activity value is MIC = 6.2 uM||Anti-Stenotrophomonus sp. YC-1, activity value is MIC = 6.2 uM||Anti-Beauveria spp, activity value is MIC = 14.1 uM||Anti-Neurospora crassa, activity value is MIC = 18.3 uM||Anti-Candida albicans, activity value is MIC = 42.8 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 18.3 uM Mesobuthus eupeus|||Mesobuthus eupeus [Lesser Asian scorpion]|||Mesobuthus eupeus (Lesser Asian scorpion)|||Mesobuthus eupeus [Lesser Asian scorpion]|||Mesobuthus eupeus|||Mesobuthus eupeus Helix||Alpha helix "In hemolysis tests conducted on meucin-13 and meucin-18: - Meucin-13 had a hemolysis rate of 37.7% at 6.25 µM, 59.2% at 12.5 µM, and was nearly complete at 25 µM. - Meucin-18 had a hemolysis rate of 74% at 6.25 µM, and was nearly complete at both 12.5 µM and 25 µM.|||Rabbit erythrocytes 59.2% lysis (12.5 uM)|||The document clearly provides the hemolytic data of two antimicrobial peptides from the venom of the Middle Eastern scorpion (Mesobuthus eupeus) (meucin-13, meucin-18). The key results are as follows (tested on rabbit red blood cells, incubation conditions 37 °C, 30 minutes, positive control 1% Triton X-100, negative control PBS buffer): • meucin-13: hemolysis rate was 37.7% at 6.25 µM, 59.2% at 12.5 µM, and nearly complete hemolysis (≈100%) at 25 µM; • meucin-18: hemolysis was significantly higher than meucin-13, with a hemolysis rate of 74% at 6.25 µM, nearly complete hemolysis (≈100%) at 12.5 µM, and complete hemolysis at 25 µM. The hemolytic strength ranking of the two peptides is: meucin-18 > meucin-13, and both are more hemolytic than scorpion-derived antimicrobial peptide IsCT and bee venom melittin at the same concentrations (the latter two only showed 25% hemolysis at 25 µM).|||Rabbit erythrocytes 59.2% lysis (12.5 uM)" FASEB J. 2009 Apr;23(4):1230-45|||19088182|||FASEB J. 2009 Apr;23(4):1230-1245.||Ref.19088182|||19088182|||FASEB J. 2009 Apr;23(4):1230-45|||FASEB J. 2009 Apr;23(4):1230-45 13 FPDB02456 AP01545|||Venom antimicrobial peptide-9|||DRAMP03751|||Venom antimicrobial peptide-9|||AP01545|||AP01545 FFGHLFKLATKIIPSLFQ Anti-Gram+ & Gram-||Antifungal||candidacidal||Insecticidal||Hemolytic||Anti-Staphylococcus aureus AB94004, activity value is MIC = 1.5 uM||Anti-Staphylococcus aureus ATCC6538, activity value is MIC = 1.5 uM||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 3 uM||Anti-Staphylococcus aureus AB208193, activity value is MIC = 3 uM||Anti-Staphylococcus epidermidis AB208187, activity value is MIC = 3 uM||Anti-Staphylococcus epidermidis AB208188, activity value is MIC = 1.5 uM||Anti-Micrococcus luteus AB93113, activity value is MIC = 47.5 uM||Anti-Bacillus thuringiensis AB92037, activity value is MIC = 3 uM||Anti-Bacillus subtilis AB91021, activity value is MIC = 3 uM||Anti-Escherichia coli AB94012, activity value is MIC = 23.7 uM||Anti-Escherichia coli ATCC25922, activity value is MIC = 11.9 uM||Anti-Pseudomonas aeruginosa ATCC9027, activity value is MIC = 11.9 uM||Anti-penicillin-resistant Staphylococcus aureus P1389, activity value is MIC = 3 uM||Anti-Methicillin-resistant Staphylococcus aureus P1374, activity value is MIC = 3 uM||Anti-methicillin-resistant Staphylococcus aureus P1381, activity value is MIC = 1.5 uM||Anti-Bacillus sp. DM-1, activity value is MIC = 0.6 uM||Anti-Micrococcus luteus, activity value is MIC = 0.6 uM||Anti-Bacillus megaterium, activity value is MIC = 0.25 uM||Anti-Agrobacterium tumefaciens, activity value is MIC = 6 uM||Anti-Escherichia coli, activity value is MIC = 2.4 uM||Anti-Shewanella oneidensis, activity value is MIC = 1.5 uM||Anti-Stenotrophomonus sp. YC-1, activity value is MIC = 2.6 uM||Anti-Salmonella typhimurium, activity value is MIC = 10.9 uM||Anti-Beauveria spp, activity value is MIC = 1.9 uM||Anti-Neurospora crassa, activity value is MIC = 5.2 uM||Anti-Candida albicans, activity value is MIC = 25.1 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 25.1 uM||Anti-Aspergillus fumigatus, activity value is MIC = 8.3 uM||Anti-Geotrichum candidum, activity value is MIC = 3.5 uM||Anti-S. cerevisiae Staphylococcus aureus AB94004, activity value is MIC = 1.5 uM Mesobuthus eupeus|||Mesobuthus eupeus [Lesser Asian scorpion]|||Mesobuthus eupeus (Lesser Asian scorpion)|||Mesobuthus eupeus|||Mesobuthus eupeus Helix||Alpha helix "In hemolysis tests conducted on meucin-13 and meucin-18: - Meucin-13 had a hemolysis rate of 37.7% at 6.25 µM, 59.2% at 12.5 µM, and was nearly complete at 25 µM. - Meucin-18 had a hemolysis rate of 74% at 6.25 µM, and was nearly complete at both 12.5 µM and 25 µM.|||The document clearly provides the hemolytic data of two antimicrobial peptides from the venom of the Middle Eastern scorpion (Mesobuthus eupeus) (meucin-13, meucin-18). The key results are as follows (tested on rabbit red blood cells, incubation conditions 37 °C, 30 minutes, positive control 1% Triton X-100, negative control PBS buffer): • meucin-13: hemolysis rate was 37.7% at 6.25 µM, 59.2% at 12.5 µM, and nearly complete hemolysis (≈100%) at 25 µM; • meucin-18: hemolysis was significantly higher than meucin-13, with a hemolysis rate of 74% at 6.25 µM, nearly complete hemolysis (≈100%) at 12.5 µM, and complete hemolysis at 25 µM. The hemolytic strength ranking of the two peptides is: meucin-18 > meucin-13, and both are more hemolytic than scorpion-derived antimicrobial peptide IsCT and bee venom melittin at the same concentrations (the latter two only showed 25% hemolysis at 25 µM).|||Rabbit erythrocytes nearly 100% lysis (12.5 uM)" FASEB J. 2009 Apr;23(4):1230-45|||19088182, 29896190||Refer PubMed ID: 29896190|||FASEB J. 2009 Apr;23(4):1230-1245.||Ref.19088182|||19088182, 29896190||Refer PubMed ID: 19088182||Refer PubMed ID: 29896190|||FASEB J. 2009 Apr;23(4):1230-45|||FASEB J. 2009 Apr;23(4):1230-45 18 FPDB02458 AP01547|||B2RP-ERa|||B2RP-ERa|||AP01547|||AP01547 GVIKSVLKGVAKTVALGML Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Escherichia coli, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus, activity value is MIC = 12.5 uM||Anti-Candida albicans, activity value is MIC = 50 uM||Anti-Acetinobacter baumannii, activity value is MIC = 6||Anti-L. salivarius DSM20554, activity value is MIC = 250 ug/ml||Anti-L. salivarius FortaFit Ls-33, activity value is MIC = 250 ug/ml||Anti-L. casei Shirota, activity value is MIC = 64 ug/ml||Anti-L. reuteri ATCC5730, activity value is MIC = 250 ug/ml||Anti-Propionibacterium acnes ATCC 11828, activity value is MIC = 12.5 uM||Anti-P. acnes strain 32548, activity value is MIC = 12.5 uM||Anti-P. acnes strain 33257, activity value is MIC = 12.5 uM||Anti-P. acnes strain 50247, activity value is MIC = 6 uM||Anti-P. acnes strain 18380, activity value is MIC = 50 uM||Anti-P. acnes strain 15725, activity value is MIC = 12.5 uM||Anti-P. acnes strain 29903, activity value is MIC = 25 uM||Anti-P. acnes strain 31766, activity value is MIC = 6 uM Asia, Hylaranaa erythraea|||Hylarana erythraea [Green paddy frog]|||Hylarana erythraea|||Asia, Hylaranaa erythraea N/A LC50=280 uM|||Human erythrocytes (LC50 = 280 uM )|||Human erythrocytes (LC50 = 280 uM ) Peptides. 2010 Apr;31(4):548-54|||20015460|||31102497|||22374306|||20015460|||Peptides. 2010 Apr;31(4):548-54|||Peptides. 2010 Apr;31(4):548-54 19 FPDB02462 AP01553|||DRAMP00752|||AP01553|||DRAMP00752 RMCKTPSGKFKGYCVNNTNCKNVCRTEGFPTGSCDFHVAGRKCYCYKPCP Anti-fungi (B. cinerea, activity value is IC50 = 0.4 ug/ml||Anti-moderate activity against C. albicans and T. reesei. Activity against bacteria Gram+ B. pumilus, activity value is IC50 = 16.2 uM||Anti-P. carotovorum, activity value is IC50 = 10.8 uM||Anti-and P. carotovorum, activity value is IC50 = 20.4 uM||Antimicrobial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Enzyme inhibitor Seeds, Scots pine, Pinus sylvestris|||Pinus sylvestris (Scots pine)|||Seeds, Scots pine, Pinus sylvestris|||Arabidopsis thaliana (Mouse-ear cress) Combine Helix and Beta structure N/A Peptides. 2009 Dec;30(12):2136-43|||Peptides. 2009 Dec;30(12):2136-2143.|||Peptides. 2009 Dec;30(12):2136-43|||Peptides. 2009 Dec;30(12):2136-2143. 50 FPDB02463 AP01554|||DRAMP03641|||AP01554|||DRAMP03641 DFGCGQGMIFMCQRRCMRLYPGSTGFCRGFRCMCDTHIPLRPPFMVG Anti-E. coli ATCC25922 or 23A or 27A, activity value is MIC = 3.2||Anti-S. aureus ATCC2592 or 6A or 15A, activity value is MIC = 0.8||Anti-P. aeruginosa 3A, activity value is MIC = 3.2 ug/ml||Anti-H. pylori NCTC11637, activity value is MIC = 6.4 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 25.6 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||Anti-Gram+ & Gram-||candidacidal salivary glands, Haemaphysalis longicornis|||Haemaphysalis longicornis|||salivary glands, Haemaphysalis longicornis|||Haemaphysalis longicornis Bridge "When the peptide concentration reaches 200 μg/ml, the hemolytic activity on rabbit red blood cells is only 1.2%.|||Hemolytic activity data of Longicornsin, a defensin-like peptide from long-horned ticks The hemolytic activity of Longicornsin is extremely low. At a concentration as high as 200 μg/ml, the hemolysis rate on rabbit red blood cells is only 1.2%.|||1.2% hemolysis at 200 ug/ml" "Protein Sci . 2010 Mar;19(3):392-7. doi: 10.1002/pro.317.|||Protein Sci. 2010 Mar;19(3):392-327.|||Protein Sci. 2010 Mar;19(3):392-7. PubMed.|||Protein Sci. 2010 Mar;19(3):392-327.|||Protein Sci. 2010 Mar;19(3):392-7. PubMed." 47 FPDB02467 AP01559|||DRAMP03280|||AP01559|||DRAMP03280 ATYDGKCYKKDNICKYKAQSGKTAICKCYVKVCPRDGAKCEFDSYKGKCYC Inhibition zone: Inhibited A. niger (11 mm)||F. solani (15 mm)||and F. oxysporum (12 mm) using 0.05 ml of 200 ug/ml. This basic||Cys-rich antifungal peptide is also active against bacteria||including S. aureus (11-19 mm)||B. cereus (15-22 mm)||M. luteus (12-18 mm)||E. faecalis (10-13 mm)||E. coli (12-16 mm)||P. aeruginosa and K.pneumonia (0 mm) treated at 50 to 200 ug/ml.||Anti-Staphylococcus aureus, activity value is MIC = 20 ug/ml||Anti-Bacillus cereus, activity value is MIC = 10 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 10 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 50 ug/ml||Anti-Escherichia coli, activity value is MIC = 30 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 50 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral||Antifungal||Anti-Gram+ & Gram- Aspergillus clavatus ES1 Bridge No hemolysis information or data found in the reference(s) presented in this entry J Ind Microbiol Biotechnol. 2010 Aug;37(8):805-13|||J Ind Microbiol Biotechnol. 2010 Aug;37(8):805-813.|||J Ind Microbiol Biotechnol. 2010 Aug;37(8):805-13|||J Ind Microbiol Biotechnol. 2010 Aug;37(8):805-813. 51 FPDB02479 AP01578|||CAMPSQ3348|||AP01578|||Myxinidin|||AP01578|||DRAMP04532 GIHDILKYGKPS Anti-S. epidermis C621 and yeast had an MBC of 10 ug/ml. Also active against E. coli ATCC 11219, activity value is MIC = 5 uM||Anti-P. aeruginosa ATCC 13388, activity value is MIC = 30 uM||Anti-S. enterica serovar Typhimurium ATCC 14028, activity value is MIC = 20 uM||Anti-K. pneumoniae ATCC 10031, activity value is MIC = 10 uM||Anti-S. aureus ATCC 6538, activity value is MIC = 10 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Antibiofilm||Wound healing||Antimicrobial||Anti-Gram+||Anti-Gram- Epidermal mucus, Myxine glutinosa L.|||Myxine glutinosa [Atlantic hagfish]|||Epidermal mucus, Myxine glutinosa L.|||Myxine glutinosa [Atlantic hagfish]|||Epidermal mucus, Myxine glutinosa L.|||Myxine glutinosa (Atlantic hagfish) Helix N/A "J Fish Dis . 2024 Apr;47(4):e13922. doi: 10.1111/jfd.13922. Epub 2024 Jan 10.|||19330556|||Mar Biotechnol (NY). 2009 Nov-Dec;11(6):748-57. PubMed|||19330556|||Mar Biotechnol (NY). 2009 Nov-Dec;11(6):748-57. PubMed|||Mar Biotechnol (NY). 2009 Nov-Dec;11(6):748-757." 12 FPDB02481 AP01581|||Phylloseptin-1|||AP01581|||DRAMP01288|||AP01581|||DRAMP01288 FLSLIPHIVSGVASIAKHF Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Hemolytic||Antibiofilm||Anti-Staphylococcus aureus, activity value is MIC = 5 uM||Anti-S. aureus, activity value is MIC = 5 uM the waxy monkey frog, Phyllomedusa sauvagei, South America|||Scylla Phyllomedusa sauvagei [Sauvage's leaf frog]|||the waxy monkey frog, Phyllomedusa sauvagei, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||the waxy monkey frog, Phyllomedusa sauvagei, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog) Helix "At 5 μM, the hemolytic activity of PSN-1 is relatively low, with a hemolysis rate of 6.7%.|||According to the document, the hemolytic value of the antimicrobial peptide Phylloseptin-1 (PSN-1) was measured using a horse red blood cell hemolysis assay (with 2% Triton X-100 treated group as 100% hemolysis control, and phosphate-buffered saline group as negative control). The key results are as follows: At the minimum inhibitory concentration (MIC) and minimum biofilm eradication concentration (MBEC) against Staphylococcus aureus (both 5 µM), the hemolysis rate of PSN-1 was only 6.7%, indicating low hemolytic activity toward mammalian red blood cells and higher selectivity for prokaryotic cell membranes over eukaryotic cell membranes. In the experiment, the PSN-1 concentration gradient ranged from 2.5 to 40 µM, and the hemolysis rate was calculated by measuring absorbance at 550 nm (formula: % hemolysis = (A - A0) / (AX - A0) × 100, where A is the absorbance of the peptide-treated group, A0 is the negative control absorbance, and AX is the positive control absorbance). The results showed that its hemolytic activity did not significantly increase with concentration, further confirming its low cytotoxicity.|||Wax monkey frog skin secretion of antimicrobial peptide PSN-1 study), PSN-1 at a concentration of 5 uM (its minimum inhibitory concentration of Staphylococcus aureus and minimum biofilm clearance concentration), the hemolysis rate of horse red blood cells is only 6.7, showing low hemolysis|||PSN-1 was found to possess a relatively low level of haemolytic activity (6.7%) at the MICandMBEC (5␮M)determined for S. aureus (Fig. 6). This experiment was repeated five times.|||6.7% at 5 uM" "Mol Immunol . 2010 Jul;47(11-12):2030-7. doi: 10.1016/j.molimm.2010.04.010. Epub 2010 May 6.|||18425600|||Mol Immunol. 2010 Jul;47(11-12):2030-7. PubMed|||Mol Immunol. 2010 Jul;47(11-12):2030-2037.|||20451254|||Mol Immunol. 2010 Jul;47(11-12):2030-7. PubMed" 19 FPDB02482 AP01582|||Psacotheasin|||AP01582|||DRAMP04573 CIAKGNGCQPSGVQGNCCSGHCHKEPGWVAGYCK Anti-tested Gram+ bacteria E. faecium ATCC 29212, activity value is MIC = 25 uM||Anti-P. acnes ATCC 6919, activity value is MIC = 12.5 uM||Anti-and S. aureus ATCC 25923, activity value is MIC = 25 uM||Antibacterial||No MICs found in DRAMP database||Anti-Gram+ & Gram-||Antifungal||candidacidal the yellow-spotted long-horned beetle, Psacothea hilaris|||Psacothea hilaris [Yellow star longhorn beetle]|||the yellow-spotted long-horned beetle, Psacothea hilaris|||Psacothea hilaris Bridge No hemolysis information or data found in the reference(s) presented in this entry "J Microbiol Biotechnol . 2010 Apr;20(4):708-11. doi: 10.4014/jmb.1002.02003.|||20467242|||J Microbiol Biotechnol. 2010 Apr;20(4):708-11. Pub-Med.|||J Microbiol Biotechnol. 2010 Apr;20(4):708-711." 34 FPDB02483 AP01583|||DRAMP04556 GWANTLKNVAGGLCKITGAA Anti-Gram+ S. aureus ATCC 2592, activity value is MIC = 37.5 ug/ml||No MICs found in DRAMP database||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antioxidant (China, Asia) Xizang plateau frog, Nanorana parkeri|||Nanorana parkeri|||Seeds, Amaranthus caudatus Helix "At a concentration of 80 ug/ml, their hemolytic activity on blood cells is very low, with specific values as follows: - Hemolysis rate of Japonicin-1Npa is 1.92%; - Hemolysis rate of Japonicin-1Npb is 3.40%; - Hemolysis rate of Parkerin is 2.36%.|||No hemolysis information or data found in the reference(s) presented in this entry" Biochimie. 2010 May;92(5):475-81|||Biochimie. 2010 May;92(5):475-481. 20 FPDB02484 AP01585|||DRAMP00957|||AP01585|||DRAMP00957 KSCCRSTQARNIYNAPRFAGGSRPLCALGSGCKIVDDKKTPPND Anti-Gram+ & Gram-||Antifungal||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- Japanese bamboo shoots, Phyllostachys pubescens|||Phyllostachys pubescens (Japanese bamboo shoots)|||Japanese bamboo shoots, Phyllostachys pubescens|||Phyllostachys pubescens (Japanese bamboo shoots) Bridge N/A Biosci Biotechnol Biochem. 2005 Mar;69(3):642-5|||Biosci Biotechnol Biochem. 2005 Mar;69(3):642-645.|||Biosci Biotechnol Biochem. 2005 Mar;69(3):642-5|||Biosci Biotechnol Biochem. 2005 Mar;69(3):642-645. 44 FPDB02485 AP01586|||DRAMP00958|||AP01586|||DRAMP00958 KSCCRSTTARNIYNGCRVPGTARPVCAKKSGCKIQEAKKCEPPYD Anti-Gram+ & Gram-||Antifungal||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- Japanese bamboo shoots, Phyllostachys pubescens|||Phyllostachys pubescens (Japanese bamboo shoots)|||Japanese bamboo shoots, Phyllostachys pubescens|||Phyllostachys pubescens (Japanese bamboo shoots) Bridge N/A Biosci Biotechnol Biochem. 2005 Mar;69(3):642-5|||Biosci Biotechnol Biochem. 2005 Mar;69(3):642-645.|||Biosci Biotechnol Biochem. 2005 Mar;69(3):642-5|||Biosci Biotechnol Biochem. 2005 Mar;69(3):642-645. 45 FPDB02486 AP01587|||DRAMP00982|||AP01587|||DRAMP00982 AQCGAQGGGATCPGGLCCSQWGWCGSTPKYCGAGCQSNCK Anti-Gram+ & Gram-||Antifungal||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- seeds, buckwheat, Fagopyrum esculentum Moench|||Fagopyrum esculentum Moench (buckwheat)|||seeds, buckwheat, Fagopyrum esculentum Moench|||Triticum kiharae (wheat) Bridge N/A Biosci Biotechnol Biochem. 2003 Aug;67(8):1636-42|||Biosci Biotechnol Biochem. 2003 Aug;67(8):1636-1642.|||Biosci Biotechnol Biochem. 2003 Aug;67(8):1636-42|||FEBS J. 2009 Aug;276(15):4266-4275.Peptides. 2005 Nov;26(11):2064-2073. 40 FPDB02487 AP01588|||DRAMP00983|||AP01588|||DRAMP00983 AQCGAQGGGATCPGGLCCSQWGWCGSTPKYCGAGCQSNCR Anti-Gram+ & Gram-||Antifungal||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- seeds, buckwheat, Fagopyrum esculentum Moench|||Fagopyrum esculentum Moench (buckwheat)|||seeds, buckwheat, Fagopyrum esculentum Moench|||Triticum kiharae (wheat) Bridge N/A Biosci Biotechnol Biochem. 2003 Aug;67(8):1636-42|||Biosci Biotechnol Biochem. 2003 Aug;67(8):1636-1642.|||Biosci Biotechnol Biochem. 2003 Aug;67(8):1636-42|||FEBS J. 2009 Aug;276(15):4266-4275.Peptides. 2005 Nov;26(11):2064-2073. 40 FPDB02490 AP01591|||CBD-1|||DRAMP02923|||AP01591|||AP01591 KCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPKFQPNMLQR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram- dog testes, Canis Lupis?|||Canis lupus [Gray wolf]|||Canis Lupis (Dog)|||dog testes, Canis Lupis?|||dog testes, Canis Lupis? Bridge N/A Infect Immun. 2005 May;73(5):2611-20|||15845463|||Infect Immun. 2005 May;73(5):2611-2620.|||Infect Immun. 2005 May;73(5):2611-20|||Infect Immun. 2005 May;73(5):2611-20 42 FPDB02495 AP01596|||DRAMP00060|||Lantibiotic cinnamycin CRQSCSFGPFTFVCDGNTK Anti-Gram+||Antifungal||Enzyme inhibitor||Hemolytic||Antimicrobial||Antbacterial||Antiviral||Antiviral ; Herpes Simplex Virus Streptomyces cinnamoneus cinnamoneus DSM 40005|||Streptomyces cinnamoneus cinnamoneus DSM 40005 (Gram-positive bacteria)|||Streptoverticillium griseoverticillatum Nonhelixbeta||Beta strand (2 strands; 2 residues) No hemolysis information or data found in the reference(s) presented in this entry "J Antibiot (Tokyo) . 1990 Nov;43(11):1403-12. doi: 10.7164/antibiotics.43.1403.|||J Antibiot (Tokyo). 1990 Nov;43(11):1403-12. PubMed|||J Antibiot (Tokyo). 1990 Nov;43(11):1403-1412.J Antibiot (Tokyo). 1989 Jun;42(6):837-845.J Biochem. 1996 Feb;119(2):226-230." 19 FPDB02511 AP01614|||Ci-MAM-A24|||AP01614|||DRAMP04562 WRSLGRTLLRLSHALKPLARRSGW Anti-Gram+ & Gram-||Antifungal||Antibacterial||No MICs found in DRAMP database Ciona intestinalis|||Ciona intestinalis [Transparent sea squirt]|||Ciona intestinalis Helix At a concentration of 12.5 μM, the peptide has minimal effects on human red blood cells. In comparison, other antimicrobial peptides exhibit similar hemolytic activity at the same concentration; whereas the positive control, bee venom’s major cytolytic peptide melittin, can cause almost complete hemolysis of red blood cells at this concentration. This indicates that the Ci-MAM-A24 peptide has very low hemolytic activity against mammalian red blood cells even at relatively high concentrations.|||Planococcus citreus ATCC 14404 ( MIC = 0.1 uM ), Vibrio alginolyticus ATCC 17749 ( MIC = 1.6 uM ), Listonella anguillarum ( MIC = 3.1 uM )|||No hemolysis information or data found in the reference(s) presented in this entry Biochem J. 2008 Nov 15;416(1):65-75|||18598239|||Biochem J. 2008 Nov 15;416(1):65-75|||Biochem J. 2008 Nov 15;416(1):65-75. 24 FPDB02530 AP01640|||CAMPSQ9296|||CAMPSQ10783|||AP01640|||DRAMP18404|||Polybia-MPII|||AP01640 INWLKLGKMVIDAL Anti-Gram+ & Gram-||Antifungal||candidacidal||Chemotactic||Hemolytic||Antibiofilm||C.albicans(EC90 = 15.3 uM)||C. neoformans (EC90 = 22.7 uM)||S. aureus (EC90 = 2.9 uM)||Anti-A. baumannii Isolate AB 02, activity value is MIC = 25 uM||Anti-A. baumannii Isolate AB 53, activity value is MIC = 12.5 uM||Anti-A. baumannii Isolate AB 72, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 2.3 ug/ml||Anti-P. aeruginosa, activity value is MIC = 9 ug/ml||Antibacterial||Anti-G+ and G- bacteria such as E. coli, activity value is MIC = 5 uM||Anti-S. aureus, activity value is MIC = 2 uM||Anti-and B. cereus, activity value is MIC = 5 uM||Anti-and P. aeruginosa, activity value is MIC = 38 uM||Anti-C. albicans, activity value is EC50 = 12.9 uM venom, social wasp, Polybia paulista; Also Pseudopolybia vespiceps testacea|||Pseudopolybia vespiceps [Social wasp]|||Pseudopolybia vespiceps testacea|||venom, social wasp, Polybia paulista; Also Pseudopolybia vespiceps testacea, South America|||venom, the social wasp, Pseudopolybia vespiceps testacea|||Pseudopolybia vespiceps [Social wasp]|||venom, social wasp, Polybia paulista; Also Pseudopolybia vespiceps testacea, South America Helix "The study measured the hemolytic activities of two novel mast cell degranulating peptides from Polybia paulista venom, Polybia-MP-II and Polybia-MP-III, using the half maximal effective concentration (ED_{50}) as an indicator. The ED_{50} values of their hemolytic activities were both 5×10^{-5} M, whereas the ED_{50 of melittin, used as a standard peptide, was 7×10^{-7} M. This indicates that Polybia-MP-II and Polybia-MP-III have hemolytic activity, with both showing the same hemolytic activity, but their hemolytic activity is weaker compared to melittin.|||According to the document, the hemolytic values of two novel mast cell degranulation peptides, Polybia-MP-II and Polybia-MP-III, isolated from the venom of the Brazilian social wasp (Polybia paulista), were determined via rat washed red blood cell (WRRBC) hemolysis assay (with 1% Triton X-100 treatment as the 100% hemolysis control). The key results are as follows: Polybia-MP-II and Polybia-MP-III: The hemolytic activities of both are consistent, with the half-maximal effective hemolysis concentration (ED_{50}) being 5×10⁻⁵ M. Control peptide (melittin): Used as a positive control, its ED_{50} is 7×10⁻⁷ M, showing hemolytic activity significantly higher than the two novel mast cell degranulation peptides, indicating that Polybia-MP-II and Polybia-MP-III have relatively low hemolytic activity toward rat red blood cells. In the experiment, the peptide concentration gradient was 10⁻⁷~10⁻⁵ M, and hemolysis was calculated by measuring absorbance at 540 nm. Results showed that the hemolytic ability of Polybia-MP-II was slightly stronger than that of Polybia-MP-III, which is related to its higher hydrophobicity and α-helix content, further demonstrating subtle differences in their interaction intensity with cell membranes.|||In this study, Polybia-MPII exhibited significant species-specific hemolytic activity, showing stronger hemolytic activity against mouse red blood cells than human red blood cells. Nevertheless, compared with similar peptides, its hemolysis rate is still relatively low, indicating a certain degree of selective toxicity. The results suggest that this peptide has potential in antibacterial therapy, but its hemolytic toxicity needs to be further optimized in subsequent studies." "Peptides . 2009 Aug;30(8):1387-95. doi: 10.1016/j.peptides.2009.05.008. Epub 2009 May 20.|||28108242|||30974767|||Peptides. 2009 Aug;30(8):1387-95. PubMed.|||Int J Antimicrob Agents. 2017 Feb;49(2):167-175. 2017|||28108242|||Peptides. 2009 Aug;30(8):1387-95. PubMed.||this ref||Silva JC et al., 2017" 14 FPDB02533 AP01643|||Pc-CATH1|||Pc-CATH1|||AP01643|||AP01643 RIKRFWPVVIRTVVAGYNLYRAIKKK Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 0.18 uM||Anti-S. aureus, activity value is MIC = 0.74 uM||Anti-S. aureus, activity value is MIC = 2.95 uM||Anti-S. aureus, activity value is MIC = 1.48 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 2.95 uM||Anti-DRa, activity value is MIC = 0.09 uM||Anti-Nocardia asteroids, activity value is MIC = 0.74 uM||Anti-Enterococcus faecalis, activity value is MIC = 2.95 uM||Anti-Enterococcus faecium, activity value is MIC = 1.48 uM||Anti-Propionibacterium acnes ATCC11827, activity value is MIC = 0.74 uM||Anti-Klebsiella oxytoca, activity value is MIC = 11.81 uM||Anti-Aeromonas sobria, activity value is MIC = 1.48 uM||Anti-DRb, activity value is MIC = 1.48 uM||Anti-A. baumannii, activity value is MIC = 1.48 uM||Anti-Stenotrophomonas maltophilia, activity value is MIC = 0.74 uM||Anti-S. maltophilia, activity value is MIC = 2.95 uM||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 5.9 uM||Anti-P. aeruginosa, activity value is MIC = 1.48 uM||Anti-P. aeruginosa, activity value is MIC = 2.95 uM||Anti-Escherichia coli ATCC25922, activity value is MIC = 1.48 uM||Anti-E. coli, activity value is MIC = 2.95 uM||Anti-E. coli, activity value is MIC = 1.48 uM||Anti-E. coli, activity value is MIC = 0.74 uM||Anti-Serratia marcescens, activity value is MIC > 31.49 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 1.48 uM||Anti-K. pneumoniae, activity value is MIC = 2.95 uM||Anti-K. pneumoniae, activity value is MIC = 5.9 uM||Anti-Proteus vulgaris, activity value is MIC = 23.62 uM||Anti-Proteus mirabilis, activity value is MIC = 1.48 uM||Anti-Salmonella typhi, activity value is MIC = 11.81 uM||Anti-Candida albicans ATCC2002, activity value is MIC = 0.18 uM||Anti-Candida glabrata, activity value is MIC = 5.9 uM||Anti-Arcyria cinerea, activity value is MIC = 0.37 uM||Anti-Cryptococcus neoformans, activity value is MIC = 23.62 uM||Anti-Gram+ S. aureus multiple strains, activity value is MIC = 0.18||Anti-S. epidermidis, activity value is MIC = 2.95 uM||Anti-S. haemolyticus, activity value is MIC = 0.09 uM||Anti-N. asteroids, activity value is MIC = 0.74 uM||Anti-E. facalis, activity value is MIC = 2.95 uM||Anti-E. faecium, activity value is MIC = 1.48 uM||Anti-P. acnes ATCC11827, activity value is MIC = 0.74 uM||Anti-K. oxytoca, activity value is MIC = 11.8 uM||Anti-S. maltophilia, activity value is MIC = 0.74 uM||Anti-P. aeruginosa multiple strains, activity value is MIC = 1.48||Anti-E. coli multiple strains, activity value is MIC = 0.74||Anti-K. pneumoniae multiple strains, activity value is MIC = 1.48||Anti-P. vulgaris, activity value is MIC = 23.6 uM||Anti-P. mirabilis, activity value is MIC = 1.48 uM||Anti-S. typhi, activity value is MIC = 11.8 uM||Anti-A. cinerea, activity value is MIC = 0.37 uM||Anti-C. neoformans, activity value is MIC = 23.6 uM pheasant, Phasianus colchicus|||Phasianus colchicus [Ring-necked pheasant]|||Phasianus colchicus [Ring-necked pheasant]|||pheasant, Phasianus colchicus|||pheasant, Phasianus colchicus N/A Hemolytic activity 13.2% 9.1% 6.3% 3.6%|||13.2% at 31.5 uM. "Dev Comp Immunol . 2011 Mar;35(3):314-22. doi: 10.1016/j.dci.2010.10.004. Epub 2010 Oct 26.|||20955730|||20955730|||Dev Comp Immunol. 2011 Mar;35(3):314-22. PubMed.|||Dev Comp Immunol. 2011 Mar;35(3):314-22. PubMed." 26 FPDB02536 AP01648|||Pelteobagrin|||Pelteobagrin|||AP01648|||DRAMP04557|||AP01648 GKLNLFLSRLEILKLFVGAL Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Antifungal ; Tachysurus fulvidraco [Yellow catfish]||No MICs found in DRAMP database the skin mucus of Yellow catfish, Pelteobagrus fulvidraco Richardson|||Tachysurus fulvidraco [Yellow catfish]|||the skin mucus of Yellow catfish, Pelteobagrus fulvidraco Richardson|||Pelteobagrus fulvidraco (Yellow catfish) N/A No hemolysis information or data found in the reference(s) presented in this entry|||no hemolytic activity Comp Biochem Physiol B Biochem Mol Biol. 2011 Feb;158(2):149-54.|||https://pubmed.ncbi.nlm.nih.gov/21073979|||21073979|||Comp Biochem Physiol B Biochem Mol Biol. 2011 Feb;158(2):149-54. ScienceDirect|||Comp Biochem Physiol B Biochem Mol Biol. 2011 Feb;158(2):149-154.|||Comp Biochem Physiol B Biochem Mol Biol. 2011 Feb;158(2):149-54. ScienceDirect 20 FPDB02537 AP01649|||Moronecidin|||Moro-NH2|||DRAMP02331|||Moronecidin|||Moro-NH2|||AP01649|||AP01649 FFHHIFRGIVHVGKTIHKLVTG Anti-Gram+ & Gram-||Antiviral||Antifungal||Antiparasitic||Anti-HIV||Enzyme inhibitor||Antimalarial||Antibacterial||Anti-Enterococcus faecalis, activity value is MIC = 5||Anti-E. faecalis, activity value is MIC = 2.5||Anti-Listeria monocytogenes, activity value is MIC = 2.5||Anti-Micrococcus luteus, activity value is MIC = 10||Anti-Staphylococcus aureus, activity value is MIC = 1.25||Anti-S. epidermidis, activity value is MIC = 5||Anti-S. saprophiticus, activity value is MIC = 5||Anti-S. xylosus, activity value is MIC > 20 uM||Anti-Streptococcus agalactiae, activity value is MIC = 1.25||Anti-S. bovis, activity value is MIC = 1.25||Anti-S. equisimilis, activity value is MIC = 2.5||Anti-S. mitis, activity value is MIC = 1.25||Anti-Streptococcus pneumoniae, activity value is MIC = 1.25||Anti-Streptococcus pyogenes, activity value is MIC = 1.25||Anti-S. iniae KST740ak, activity value is MIC = 1.25||Anti-S. iniae KSTSi 6P, activity value is MIC = 1.25||Anti-Aeromonas hydrophila, activity value is MIC > 20 uM||Anti-Burkholderia cepacia, activity value is MIC > 20 uM||Anti-Vibrio cholera, activity value is MIC = 2.5||Anti-Escherichia coli, activity value is MIC = 5||Anti-Moraxella catarrhalis, activity value is MIC = 2.5||Anti-Neisseria gonorrhoeae, activity value is MIC > 20 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 5||Anti-Enterobacter cloacae, activity value is MIC = 10||Anti-E. aerogenes, activity value is MIC = 10||Anti-Klebsiella pneumoniae, activity value is MIC = 2.5||Anti-K. oxytoca, activity value is MIC = 5||Anti-Salmonella choleraesuis, activity value is MIC = 10||Anti-Salmonella typhimurium, activity value is MIC = 10||Anti-S. arizonae, activity value is MIC = 10||Anti-Serratia marcescens, activity value is MIC > 20 uM||Anti-Shigella flexneri, activity value is MIC = 2.5||Anti-S. sonnei, activity value is MIC = 5||Anti-Yersinia enterocolitica, activity value is MIC = 2.5||Anti-Aspergillus fumigatus, activity value is MIC = 50||Anti-Fusarium oxysporum, activity value is MIC = 0.78||Anti-F. culmorum, activity value is MIC = 0.39||Anti-Candida albicans, activity value is MIC = 10||Anti-C. glabrata, activity value is MIC = 10||Anti-C. lusitania, activity value is MIC = 10||Anti-C. tropicalis, activity value is MIC = 10||Anti-E. faecalis, activity value is MIC = 5||Anti-M. luteus, activity value is MIC = 10||Anti-S. aureus, activity value is MIC = 1.252||Anti-Staphylococcus epidermidis, activity value is MIC = 5||Anti-Staphylococcus saprophiticus, activity value is MIC = 5||Anti-Streptococcus bovis, activity value is MIC = 1.25||Anti-Streptococcus equisimilis, activity value is MIC = 2.5||Anti-Streptococcus mitis, activity value is MIC = 1.25||Anti-KST740ak, activity value is MIC = 1.25||Anti-KSTSi 6P, activity value is MIC = 1.25||Anti-E. coli, activity value is MIC = 5||Anti-Enterobacter aerogenes, activity value is MIC = 10||Anti-Klebsiella oxytoca, activity value is MIC = 5||Anti-P. aeruginosa, activity value is MIC = 5||Anti-Salmonella arizonae, activity value is MIC = 10||Anti-S. flexneri, activity value is MIC = 2.5||Anti-Shigella sonnei, activity value is MIC = 5||Anti-N. crassa, activity value is MIC = 1.56||Anti-A. fumigatus, activity value is MIC = 50||Anti-F. oxysporum, activity value is MIC = 0.78||Anti-Candida glabrata, activity value is MIC = 10||Anti-Candida lusitania, activity value is MIC = 10||Anti-Candida tropicalis, activity value is MIC = 10||Anti-Pseudomonas aeruginosa, activity value is MIC = 50 uM||Anti-E. cloacae ATCC 13047, activity value is MIC = 25 uM||Anti-S. sonnei, activity value is MIC = 5 uM||Anti-Psychrobacter sp, activity value is MIC = 2.5 uM||Anti-E. coli DH5alpha, activity value is MIC = 5 uM||Anti-E. faecalis, activity value is MIC = 5 uM||Anti-S. pyogenes, activity value is MIC = 2.5 uM||Anti-S. aureus, activity value is MIC = 2.5 uM||Anti-L. monocytogenes, activity value is MIC = 2.5 uM||Anti-C. tropicalis, activity value is MIC = 5 uM||Anti-fish pathogens S. iniae, activity value is MIC = 2.46 uM||Anti-L. garvieae, activity value is MIC = 0.61 uM||Anti-V. anguillarum, activity value is MIC = 4.91 uM||Anti-A-salmonicida, activity value is MIC > 78.61 uM||Anti-human pathogens E. faecalis, activity value is MIC = 1.23 uM||Anti-S. aureus, activity value is MIC = 2.46 uM||Anti-S. flexneri, activity value is MIC = 2.46 uM||Anti-and E. coli, activity value is MIC = 4.91 uM Mast cells, hybrid striped bass (Morone saxatilis x Morone chrysops)|||Morone chrysops x Morone saxatilis [White bass x Striped bass]|||Hybrid striped bass|||Morone chrysops (White bass)|||Mast cells, hybrid striped bass (Morone saxatilis x Morone chrysops)|||Mast cells, hybrid striped bass (Morone saxatilis x Morone chrysops) Helix E. faecalis ( MIC = 5-10 uM), E. faecalis ( MIC = 2.5-5 uM), Listeria monocytogenes ( MIC = 2.5-5 uM), M. luteus ( MIC = 10-20 uM), S. aureus ( MIC = 1.252-5 uM), Staphylococcus epidermidis ( MIC = 5-10 uM), Staphylococcus saprophiticus ( MIC = 5-10 uM), Staphylococcus xylosus ( MIC = >20 uM), Streptococcus agalactiae ( MIC = 1.25-2.5 uM), Streptococcus bovis ( MIC = 1.25-2.5 uM), Streptococcus equisimilis ( MIC = 2.5-5 uM), Streptococcus mitis ( MIC = 1.25-2.5 uM), Streptococcus pneumoniae ( MIC = 1.25-2.5 uM), Streptococcus pyogenes ( MIC = 1.25-2.5 uM), S. iniae, KST740ak ( MIC = 1.25-2.5 uM), S. iniae, KSTSi 6P ( MIC = 1.25-2.5 uM), A. hydrophila ( MIC = >20 uM), Burkholderia cepacia ( MIC = >20 uM), Vibrio cholera ( MIC = 2.5-5 uM), E. coli ( MIC = 5-10 uM), Enterobacter cloacae ( MIC = 10-20 uM), Enterobacter aerogenes ( MIC = 10-20 uM), Klebsiella pneumoniae ( MIC = 2.5-5 uM), Klebsiella oxytoca ( MIC = 5-10 uM), Moraxella catarrhalis ( MIC = 2.5-5 uM), N. gonorrhea ( MIC = >20 uM), P. aeruginosa ( MIC = 5-10 uM), Salmonella choleraesuis ( MIC = 10-20 uM), Salmonella typhimurium ( MIC = 10-20 uM), Salmonella arizonae ( MIC = 10-20 uM), S. marcescens ( MIC = >20 uM), S. flexneri ( MIC = 2.5-5 uM), Shigella sonnei ( MIC = 5-10 uM), Yersinia enterocolitica ( MIC = 2.5-5 uM), N. crassa ( MIC = 1.56-3.12 uM), A. fumigatus ( MIC = 50-100 uM), F. oxysporum ( MIC = 0.78-1.56 uM), F. culmorum ( MIC = 0.39-0.78 uM), Candida albicans ( MIC = 10-20 uM), Candida glabrata ( MIC = 10-20 uM), Candida lusitania ( MIC = 10-20 uM), Candida tropicalis ( MIC = 10-20 uM).|||Pseudomonas aeruginosa (ATCC 15442)(MIC = 50 uM), Burkholderia cepacia (ATCC 25416)(MIC = >50 uM), E. cloacae ATCC 13047 (MIC = 25 uM), S. sonnei (ATCC 29930) (MIC = 5 uM), Psychrobacter sp. (PAMC 25501) (MIC = 2.5 uM), E. coli DH5alpha (MIC = 5 uM), E. faecalis (ATCC 29212) (MIC = 5 uM), S. pyogenes (ATCC 19615) (MIC = 2.5 uM), S. aureus (ATCC 33591)(MIC= 2.5 uM), L. monocytogenes (ATCC 15313) (MIC =2.5 uM), C. tropicalis (ATCC 20115) (MIC = 5 uM), Candida glabrata (ATCC 2001)(MIC =>50 uM) Nature. 2001 Nov 15;414(6861):268-9|||11739390|||28122029|||11739390|||28122029|||Nature. 2001 Nov 15;414(6861):268-9||see ref AP2785|||Nature. 2001 Nov 15;414(6861):268-9 22 FPDB02544 AP01658|||Shuchin 1|||Shuchin 1|||AP01658|||DRAMP04547|||AP01658 " NALSMPRNKCNRALMCFG" Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Antifungal ; Staphylococcus aureus||Bacillus cereus||Escherichia coli||Bacillus dysenteriae||Pseudomonas aeruginosa||Candida albicans||No MICs found in DRAMP database Rana shuchinae, China, Asia|||Rana shuchinae [Sichuan frog]|||Rana shuchinae, China, Asia|||Rana shuchinae N/A No hemolysis information or data found in the reference(s) presented in this entry Anti-Gram+ & Gram-, Antifungal, candidacidal|||20553780|||20553780|||Peptides. 2010 Sep;31(9):1674-7|||Peptides. 2010 Sep;31(9):1674-1677.|||Peptides. 2010 Sep;31(9):1674-7 18 FPDB02545 AP01659|||Shuchin 2|||Shuchin 2|||AP01659|||DRAMP04548|||AP01659 NALSSPRNKCDRASSCFG Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Antifungal ; Staphylococcus aureus||Bacillus cereus||Escherichia coli||Bacillus dysenteriae||Pseudomonas aeruginosa||Candida albicans||No MICs found in DRAMP database Rana shuchinae, China, Asia|||Rana shuchinae [Sichuan frog]|||Rana shuchinae, China, Asia|||Rana shuchinae N/A The study measured the hemolytic activity of a novel antimicrobial peptide Shuchin in the skin secretions of the Chinese forest frog (Rana shuchinae), and when the concentration of Shuchin reached 200 μg/ml, the hemolysis rate of rabbit red blood cells was only 2%.|||No hemolysis information or data found in the reference(s) presented in this entry Peptides. 2010 Sep;31(9):1674-7|||20553780|||20553780|||Peptides. 2010 Sep;31(9):1674-7|||Peptides. 2010 Sep;31(9):1674-1677.|||Peptides. 2010 Sep;31(9):1674-7 18 FPDB02547 AP01661|||Neutrophil defensin 1|||DRAMP02653|||Neutrophil defensin 1|||AP01661|||DRAMP02653|||AP01661 ACYCRIPACLAGERRYGTCFYLGRVWAFCC Anti-Gram+||Antifungal||Neutrophil defensin 1||Antimicrobial||Antibacterial||Anti-Gram- leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||Macaca mulatta [Rhesus macaque]|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus macaque)|||leukocytes, Rhesus Macaque (Macaca mulatta) Bridge L. monocytogenes, S. aureus, C. neoformans "Infect Immun . 1999 Nov;67(11):6139-44. doi: 10.1128/IAI.67.11.6139-6144.1999.|||10531277|||Infect Immun. 1999 Nov;67(11):6139-6144.|||10531277|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed.|||Infect Immun. 1999 Nov;67(11):6139-6144.|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed." 30 FPDB02548 AP01662|||Neutrophil defensin 3|||DRAMP02659|||Neutrophil defensin 3|||AP01662|||DRAMP02659|||AP01662 " ACYCRIPACLAGERRYGTCFYRRRVWAFCC" Anti-Gram+||Antifungal||Antibacterial||Antimicrobial||Anti-Gram- leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus monkey)|||Macaca mulatta [Rhesus macaque]|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus monkey)|||leukocytes, Rhesus Macaque (Macaca mulatta) Bridge N/A "Infect Immun . 1999 Nov;67(11):6139-44. doi: 10.1128/IAI.67.11.6139-6144.1999.|||10531277|||Infect Immun. 1999 Nov;67(11):6139-6144.|||10531277|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed.|||Infect Immun. 1999 Nov;67(11):6139-6144.|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed." 30 FPDB02549 AP01664|||DRAMP02661|||RMAD-5|||AP01664|||DRAMP02661 RTCRCRFGRCFRRESYSGSCNINGRIFSLCCR Anti-Gram+||Antifungal||Antimicrobial||Antibacterial||Anti-Gram- leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus monkey)|||Macaca mulatta [Rhesus macaque]|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus monkey) Bridge N/A "Infect Immun . 1999 Nov;67(11):6139-44. doi: 10.1128/IAI.67.11.6139-6144.1999.|||Infect Immun. 1999 Nov;67(11):6139-6144.|||10531277|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed.|||Infect Immun. 1999 Nov;67(11):6139-6144.|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed." 32 FPDB02550 AP01665|||DRAMP02662|||Neutrophil defensin 6|||AP01665|||DRAMP02662 RRTCRCRFGRCFRRESYSGSCNINGRISSLCCR Anti-Gram+||Antifungal||Antimicrobial||Antibacterial||Anti-Gram- leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus monkey)|||Macaca mulatta [Rhesus macaque]|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus monkey) Bridge N/A "Infect Immun . 1999 Nov;67(11):6139-44. doi: 10.1128/IAI.67.11.6139-6144.1999.|||Infect Immun. 1999 Nov;67(11):6139-6144.|||10531277|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed.|||Infect Immun. 1999 Nov;67(11):6139-6144.|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed." 33 FPDB02551 AP01666|||DRAMP02663|||RMAD-7|||AP01666|||DRAMP02663 RTCRCRFGRCFRRESYSGSCNINGRISSLCCR Anti-Gram+||Antifungal||Antimicrobial||Antibacterial||Anti-Gram- leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus monkey)|||Macaca mulatta [Rhesus macaque]|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus monkey) Bridge N/A "Infect Immun . 1999 Nov;67(11):6139-44. doi: 10.1128/IAI.67.11.6139-6144.1999.|||Infect Immun. 1999 Nov;67(11):6139-6144.|||10531277|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed.|||Infect Immun. 1999 Nov;67(11):6139-6144.|||Infect Immun. 1999 Nov;67(11):6139-44. PubMed." 32 FPDB02552 AP01667|||DRAMP03199|||PhD1|||AP01667|||DRAMP03199 RRICRCRIGRCLGLEVYFGVCFLHGRLARRCCR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- blood leukocytes, Papio hamadryas|||Papio hamadryas (Hamadryas baboon)|||Papio hamadryas [Hamadryas baboon]|||blood leukocytes, Papio hamadryas|||Papio hamadryas (Hamadryas baboon) Bridge Preparation of leukocyte mass enriched in neu trophilic granulocytes. It was possible to obtain 200 ml of whole blood from two adult female baboons. After hemolysis of erythrocytes and leukocyte sedimentation, the amount of wet leukocyte mass was 1900000 ug. Differential cell count in the smears of the leukocyte preparation showed about 70% of neutrophils, 5% of eosinophils and basophiles, and 25% of monocytes and lymphocytes. "Biochemistry (Mosc) . 2006 Aug;71(8):879-83. doi: 10.1134/s0006297906080098.|||Biochemistry (Mosc). 2006 Aug;71(8):879-883.|||16978151|||Biochemistry (Mosc). 2006 Aug;71(8):879-83. PubMed.|||Biochem J. 2008 May 1;411(3):687-696.|||Biochemistry (Mosc). 2006 Aug;71(8):879-83. PubMed." 33 FPDB02553 AP01668|||DRAMP03200|||Defensin-1|||AP01668|||DRAMP03200 RICRCRIGRCLGLEVYFGVCFLHGRLARRCCR Anti-Gram+ & Gram-||Antifungal||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- blood leukocytes, Papio hamadryas|||Papio hamadryas (Hamadryas baboon)|||Papio hamadryas [Hamadryas baboon]|||blood leukocytes, Papio hamadryas|||Papio hamadryas (Hamadryas baboon) Bridge Preparation of leukocyte mass enriched in neu trophilic granulocytes. It was possible to obtain 200 ml of whole blood from two adult female baboons. After hemolysis of erythrocytes and leukocyte sedimentation, the amount of wet leukocyte mass was 1900000 ug. Differential cell count in the smears of the leukocyte preparation showed about 70% of neutrophils, 5% of eosinophils and basophiles, and 26% of monocytes and lymphocytes. "Biochemistry (Mosc) . 2006 Aug;71(8):879-83. doi: 10.1134/s0006297906080098.|||Biochemistry (Mosc). 2006 Aug;71(8):879-83.|||16978151|||Biochemistry (Mosc). 2006 Aug;71(8):879-83 PubMed.|||Appl Environ Microbiol. 2014 Apr;80(8):2633-43.|||Biochemistry (Mosc). 2006 Aug;71(8):879-83 PubMed." 32 FPDB02554 AP01669|||DRAMP03201|||Defensin-3|||AP01669|||DRAMP03201 RTCRCRLGRCSRRESYSGSCNINGRIYSLCCR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- blood leukocytes, Papio hamadryas|||Papio hamadryas (Hamadryas baboon)|||Papio hamadryas [Hamadryas baboon]|||blood leukocytes, Papio hamadryas|||Papio hamadryas (Hamadryas baboon) Bridge Preparation of leukocyte mass enriched in neu trophilic granulocytes. It was possible to obtain 200 ml of whole blood from two adult female baboons. After hemolysis of erythrocytes and leukocyte sedimentation, the amount of wet leukocyte mass was 1900000 ug. Differential cell count in the smears of the leukocyte preparation showed about 70% of neutrophils, 5% of eosinophils and basophiles, and 27% of monocytes and lymphocytes. "Biochemistry (Mosc) . 2006 Aug;71(8):879-83. doi: 10.1134/s0006297906080098.|||Biochemistry (Mosc). 2006 Aug;71(8):879-883.|||16978151|||Biochemistry (Mosc). 2006 Aug;71(8):879-83 PubMed.|||FEMS Microbiol Lett.J Appl Microbiol.|||Biochemistry (Mosc). 2006 Aug;71(8):879-83 PubMed." 32 FPDB02556 AP01673|||RTD-4|||DRAMP02645|||RTD-4|||AP01673|||DRAMP02645|||DRAMP02646|||AP01673 GICRCICTRGFCRCICVL Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Antimicrobial||Antifungal ; Staphylococcus aureus||Escherichia coli||Candida albicans leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus macaque)|||leukocytes, Rhesus Macaque (Macaca mulatta) Bridge N/A J Leukoc Biol. 2011 Feb;89(2):283-90|||21084627|||J Leukoc Biol. 2011 Feb;89(2):283-290.|||21084627|||J Leukoc Biol. 2011 Feb;89(2):283-90|||J Leukoc Biol. 2011 Feb;89(2):283-290.|||J Leukoc Biol. 2011 Feb;89(2):283-90 18 FPDB02557 AP01674|||RTD-5|||DRAMP02646|||RTD-5|||AP01674|||AP01674 GICRCLCRRGVCRCICVL Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Antimicrobial||Antifungal ; Staphylococcus aureus||Escherichia coli||Candida albicans leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||leukocytes, Rhesus Macaque (Macaca mulatta) Bridge N/A J Leukoc Biol. 2011 Feb;89(2):283-90|||21084627|||J Leukoc Biol. 2011 Feb;89(2):283-290.|||21084627|||J Leukoc Biol. 2011 Feb;89(2):283-90|||J Leukoc Biol. 2011 Feb;89(2):283-90 18 FPDB02558 AP01675|||AP01676|||Beta-amyloid peptide|||AP01676 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA Anti-Gram+ & Gram-||Antiviral||Antifungal||Synergistic AMPs||Antiparasitic||Anti-HIV||Enzyme inhibitor||Antimalarial||Antibacterial||It also inhibits Herpes simplex virus 1 (HSV-1) . H4 neuroglioma cells produced A-beta42 in response to HSV-1 infection thus inhibiting secondary replication . It also inhibits influenza A virus (White et al. 2014 ). Homo sapiens|||Homo sapiens [Humans]|||Homo sapiens Helix N/A PLoS One. 2010 Mar 3;5(3):e9505|||20209079|||PLoS One. 2010 Mar 3;5(3):e9505||Bourgade K et al., 2014||Bourgade K et al., 2016|||PLoS One. 2010 Mar 3;5(3):e9505 42 FPDB02559 AP01680 ILGIITSLLKSLGKK Anti-Gram+||Antifungal||candidacidal venom, solitary wasp, Orancistrocerus drewseni (Hymenoptera: Eumenidae)|||venom, solitary wasp, Orancistrocerus drewseni (Hymenoptera: Eumenidae), South America N/A N/A Toxicon. 2010 Apr 1;55(4):711-8 15 FPDB02561 AP01689|||Hybrid peptide LFT33, LfcinB|||AP01689 FKCRRWQWRWKKLGAKPVPIIYCNRRTGKCQRM Anti-Gram+ & Gram-||Antifungal||Antibacterial||Anti-S. aureus ATCC25923, activity value is IC50 = 16 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is IC50 = 32 ug/ml||Anti-E. coli O78, activity value is IC50 = 32 ug/ml||Anti-S. pullorum CCVC533, activity value is IC50 = 32 ug/ml||Anti-E. aerogenes HC2124, activity value is IC50 = 16 ug/ml||Anti-K. pneumoniae HC2187, activity value is IC50 = 32 ug/ml||Anti-and C. albicans HC3150, activity value is IC50 = 64 ug/ml designed, hybrid peptide, man-made sequences|||Synthetic construct|||designed, hybrid peptide, man-made sequences N/A Human erythrocytes (- at NA|||not hemo.lytic at 256 ug/ml. "Appl Microbiol Biotechnol . 2012 Sep;95(5):1191-8. doi: 10.1007/s00253-011-3816-z. Epub 2011 Dec 22.|||22189867|||Appl Microbiol Biotechnol. 2012 Sep;95(5):1191-8. doi: 10.1007/s00253-011-3816-z. Pub-Med.|||Appl Microbiol Biotechnol. 2012 Sep;95(5):1191-8. doi: 10.1007/s00253-011-3816-z. Pub-Med." 33 FPDB02562 AP01693|||Defensin D1|||DRAMP00397|||AP01693|||DRAMP00397|||AP01693 KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKPPAHRCICYYEC Anti-Gram+ & Gram-||Antifungal||Anti-Aspergillus niger, activity value is IC50 = 3.5 ug/ml||Anti-Fusarium oxysporum, activity value is IC50 = 9.5 ug/ml||Anti-Phytophthora infestans, activity value is IC50 = 13.6 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- seeds, Nigella sativa L.|||Nigella sativa [Black cumin]|||Nigella sativa (Black cumin)|||seeds, Nigella sativa L.|||Nigella sativa (Black cumin)|||seeds, Nigella sativa L. Bridge N/A Plant Physiol Biochem. 2011 Feb;49(2):131-7|||21144761|||Plant Physiol Biochem. 2011 Feb;49(2):131-137.|||Plant Physiol Biochem. 2011 Feb;49(2):131-7|||Plant Physiol Biochem. 2011 Feb;49(2):131-137.|||Plant Physiol Biochem. 2011 Feb;49(2):131-7 50 FPDB02563 AP01694|||Defensin D2|||DRAMP00398|||AP01694|||DRAMP00398|||AP01694 KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKLPAHRCICYYEC Anti-Gram+ & Gram-||Antifungal||Anti-Phytophthora infestans, activity value is IC50 = 3.4 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- seeds, Nigella sativa L.|||Nigella sativa [Black cumin]|||Nigella sativa (Black cumin)|||seeds, Nigella sativa L.|||Nigella sativa (Black cumin)|||seeds, Nigella sativa L. Bridge N/A Plant Physiol Biochem. 2011 Feb;49(2):131-7|||21144761|||Plant Physiol Biochem. 2011 Feb;49(2):131-137.|||Plant Physiol Biochem. 2011 Feb;49(2):131-7|||Plant Physiol Biochem. 2011 Feb;49(2):131-137.|||Plant Physiol Biochem. 2011 Feb;49(2):131-7 50 FPDB02565 AP01696 SPAGCRFCCGCCPNMRGCGVCCRF Anti-Gram+ & Gram-||Antifungal liver-expressed, black porgy, Acanthopagrus schlegelii Bridge N/A Comp Biochem Physiol B Biochem Mol Biol. 2011 Feb;158(2):155-63. 24 FPDB02572 AP01713|||DRAMP04589 SRSGRGSGKGGRGGSRGSSGSRGSKGPSGSRGSSGSRGSKGSRGGRSGRGSTIAGNGNRNNGGTRTA Anti-Gram+ & Gram-||Antifungal||No MICs found in DRAMP database kidney/Spleen, Atlantic cod, Gadus morhua|||Gadus morhua Rich No hemolysis information or data found in the reference(s) presented in this entry Dev Comp Immunol. 2011 Mar;35(3):296-303|||Dev Comp Immunol. 2011 Mar;35(3):296-303. 67 FPDB02576 AP01717|||Esculentin-2PRb|||Esculentin-2PRb|||AP01717|||AP01717 GIFSALAAGVKLLGNTLFKMAGKAGAEHLACKATNQC Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Antibacterial||Anti-E. coli ATCC 25726, activity value is MIC = 25 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 50 uM North America,the Oregon spotted frog Rana pretiosa|||Rana pretiosa|||Rana pretiosa|||North America,the Oregon spotted frog Rana pretiosa|||North America,the Oregon spotted frog Rana pretiosa N/A "This study measured the hemolytic activity (LC_{50}, half-maximal hemolytic concentration) of various antimicrobial peptides from the skin secretions of the Oregon spotted frog on human red blood cells, with specific values as follows: Esculentin-2PRb at 35 μM; Ranatuerin-2PRe at 90 μM; Brevinin-1PRa at 150 μM; Brevinin-1PRb at 80 μM; Brevinin-1PRd at 5 μM; Temporin-PRb at 35 μM; Temporin-PRc at 80 μM. In addition, LC_{50} values for Ranatuerin-2PRa, Ranatuerin-2PRb, and Ranatuerin-2PRd are >100 μM, while hemolytic values for Esculentin-2PRa, Brevinin-1PRc, and Temporin-PRa were not determined (""ND"" in the original text indicates not determined).|||Human erythrocytes ( LC50 = 35 uM )|||Human erythrocytes ( LC50 = 35 uM )|||HC50 35 uM" Dev Comp Immunol. 2011 Jun;35(6):644-9.|||21295070|||21295070|||Dev Comp Immunol. 2011 Jun;35(6):644-9|||Dev Comp Immunol. 2011 Jun;35(6):644-9 37 FPDB02580 AP01721|||Brevinin-1PRa|||DRAMP02086|||Brevinin-1PRa|||AP01721|||DRAMP02086|||AP01721 FLPVLTGLTPSIVPKLVCLLTKKC Anti-Gram+||Antifungal||candidacidal||Hemolytic||Antibacterial||Anti-Escherichia coli, activity value is MIC > 100 uM||Anti-Staphylococcus aureus, activity value is MIC = 13 uM||Anti-Candida albicans, activity value is MIC = 100 uM||Anti-Staphylococcus aureus, activity value is MIC = 50 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 50 uM||Anti-E. coli ATCC 25726, activity value is MIC > 100 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 100 uM||Antimicrobial||Anti-Gram- North America, the Oregon spotted frog Rana pretiosa|||Rana pretiosa|||Rana pretiosa (North oregon spotted frog)|||Rana pretiosa|||North America, the Oregon spotted frog Rana pretiosa|||Rana pretiosa (North oregon spotted frog)|||North America, the Oregon spotted frog Rana pretiosa N/A "This study measured the hemolytic activity (LC_{50}, half-maximal hemolytic concentration) of various antimicrobial peptides from the skin secretions of the Oregon spotted frog on human red blood cells, with specific values as follows: Esculentin-2PRb at 35 μM; Ranatuerin-2PRe at 90 μM; Brevinin-1PRa at 150 μM; Brevinin-1PRb at 80 μM; Brevinin-1PRd at 5 μM; Temporin-PRb at 35 μM; Temporin-PRc at 80 μM. In addition, LC_{50} values for Ranatuerin-2PRa, Ranatuerin-2PRb, and Ranatuerin-2PRd are >100 μM, while hemolytic values for Esculentin-2PRa, Brevinin-1PRc, and Temporin-PRa were not determined (""ND"" in the original text indicates not determined).|||Human erythrocytes ( LC50 = 150 uM )|||Human erythrocytes ( LC50 = 150 uM )|||HC50 7 uM" "Dev Comp Immunol . 2011 Jun;35(6):644-9. doi: 10.1016/j.dci.2011.01.017. Epub 2011 Feb 1.|||21295070|||Regul Pept. 2004 May 15;118(3):135-141.||Ref.15003829||Ref.21295070|||21295070|||Dev Comp Immunol. 2011 Jun;35(6):644-9. PubMed|||Regul Pept. 2004 May 15;118(3):135-141.Dev Comp Immunol. 2011 Jun;35(6):644-649.|||Dev Comp Immunol. 2011 Jun;35(6):644-9. PubMed" 24 FPDB02581 AP01722|||Brevinin-1PRb|||DRAMP02087|||Brevinin-1PRb|||AP01722|||DRAMP02087|||AP01722 FLPVLAGLTPSIVPKLVCLLTKKC Anti-Gram+||Antifungal||candidacidal||Antibacterial||Antimicrobial||Anti-E. coli ATCC 25726, activity value is MIC > 100 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 25 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 25 uM North America, the Oregon spotted frog Rana pretiosa|||Rana pretiosa|||Rana pretiosa (North oregon spotted frog)|||Rana pretiosa|||North America, the Oregon spotted frog Rana pretiosa|||Rana pretiosa (North oregon spotted frog)|||North America, the Oregon spotted frog Rana pretiosa N/A "This study measured the hemolytic activity (LC_{50}, half-maximal hemolytic concentration) of various antimicrobial peptides from the skin secretions of the Oregon spotted frog on human red blood cells, with specific values as follows: Esculentin-2PRb at 35 μM; Ranatuerin-2PRe at 90 μM; Brevinin-1PRa at 150 μM; Brevinin-1PRb at 80 μM; Brevinin-1PRd at 5 μM; Temporin-PRb at 35 μM; Temporin-PRc at 80 μM. In addition, LC_{50} values for Ranatuerin-2PRa, Ranatuerin-2PRb, and Ranatuerin-2PRd are >100 μM, while hemolytic values for Esculentin-2PRa, Brevinin-1PRc, and Temporin-PRa were not determined (""ND"" in the original text indicates not determined).|||E. coli ATCC 25726 ( MIC > 100 uM ), S. aureus ATCC 25923 ( MIC = 25 uM ), Candida albicans ATCC 90028 ( MIC = 25 uM )|||Human erythrocytes ( LC50 = 80 uM )" "Dev Comp Immunol . 2011 Jun;35(6):644-9. doi: 10.1016/j.dci.2011.01.017. Epub 2011 Feb 1.|||21295070|||Dev Comp Immunol. 2011 Jun;35(6):644-649.|||21295070|||Dev Comp Immunol. 2011 Jun;35(6):644-9. PubMed|||Extremophiles. 2003 Oct;7(5):401-7.Mol Microbiol. 2005 Jul;57(2):537-49.|||Dev Comp Immunol. 2011 Jun;35(6):644-9. PubMed" 24 FPDB02588 AP01731|||Maximin 28|||Maximin 28|||AP01731|||AP01731 GIGTKFLGGVKTALKGALKELASTYVN Anti-Proteomics: Only active peptides with, activity value is MIC < 100 ug/ml||Anti-S. aureus ATCC 25923, activity value is MIC = 4.7 ug/ml||Anti-E. coli ATCC 25922, activity value is MIC = 9.4 ug/ml||Anti-and B. subtilis ATCC 6633, activity value is MIC = 75 ug/ml||Anti-Candida albicans ATCC 20032, activity value is MIC = 75 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.7 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 9.4 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 75 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal brain, Bombina maxima, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima [Giant fire-bellied toad]|||brain, Bombina maxima, China, Asia|||brain, Bombina maxima, China, Asia N/A qevrn26xel98j4c9x0qa|||Human erythrocytes ( 27.7 % hemolysis at 125 ug/ml ), Rabiit erythrocytes ( 12.1 % hemolysis at 125 ug/ml )|||Human erythrocytes ( 27.7 % hemolysis at 125 ug/ml ), Rabiit erythrocytes ( 12.1 % hemolysis at 125 ug/ml )|||As listed in Table 5, the hemolytic activities of26 antimicrobial peptides with three different concentrations (0.0625, 0.125, and 250 ug/ml) against human and rabbit red cells were tested. They show stronger hemolytic activities against human red cells than rabbit red cells. The only exception is maximin H52. It is hemolytic ability to rabbit red cells is stronger than human red cells. But at a low concentration (62.5 ug/ml) of maximin H52, it induced 36.5 and 5% hemolysis ofhuman and rabbit red cells, respectively. Maximin 31, 39, 41, 42, and 77 and maximin H5, H23, H24, H27, H37, H46 and H54 have little hemolytic activity against rabbit red cells while only maximin H5, H23,|||HC50 >250 ug/ml "J Proteome Res . 2011 Apr 1;10(4):1806-15. doi: 10.1021/pr101285n. Epub 2011 Mar 10.|||21338048|||21338048|||J Proteome Res. 2011 Apr 1;10(4):1806-15. PubMed|||J Proteome Res. 2011 Apr 1;10(4):1806-15. PubMed" 27 FPDB02597 AP01740|||Maximin 68|||Maximin 68|||AP01740|||AP01740 GIGGALLSAGKAALKGLAKVLV Anti-Proteomics: Only active peptides with, activity value is MIC < 100 ug/ml||Anti-S. aureus ATCC 25923, activity value is MIC = 9.4 ug/ml||Anti-E. coli ATCC 25922, activity value is MIC = 37.5 ug/ml||Anti-and B. subtilis ATCC 6633, activity value is MIC = 9.4 ug/ml||Antibacterial||Antifungal||Anti-Candida albicans ATCC 20032, activity value is MIC = 18.8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 9.4 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 37.5 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 9.4 ug/ml||Anti-Gram+ & Gram-||candidacidal brain, Bombina maxima, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||brain, Bombina maxima, China, Asia N/A qevrn26xel98j4c9x0qa|||Human erythrocytes ( 44.8 % hemolysis at 125 ug/ml ), Rabiit erythrocytes ( 25.9 % hemolysis at 125 ug/ml )|||Human erythrocytes ( 44.8 % hemolysis at 125 ug/ml ), Rabiit erythrocytes ( 25.9 % hemolysis at 125 ug/ml )|||As listed in Table 5, the hemolytic activities of26 antimicrobial peptides with three different concentrations (0.0625, 0.125, and 250 ug/ml) against human and rabbit red cells were tested. They show stronger hemolytic activities against human red cells than rabbit red cells. The only exception is maximin H52. It is hemolytic ability to rabbit red cells is stronger than human red cells. But at a low concentration (62.5 ug/ml) of maximin H52, it induced 36.5 and 5% hemolysis ofhuman and rabbit red cells, respectively. Maximin 31, 39, 41, 42, and 77 and maximin H5, H23, H24, H27, H37, H46 and H54 have little hemolytic activity against rabbit red cells while only maximin H5, H24,|||HC50 125 ug/ml "J Proteome Res . 2011 Apr 1;10(4):1806-15. doi: 10.1021/pr101285n. Epub 2011 Mar 10.|||21338048|||21338048|||J Proteome Res. 2011 Apr 1;10(4):1806-15. PubMed|||J Proteome Res. 2011 Apr 1;10(4):1806-15. PubMed" 22 FPDB02600 AP01743|||Maximin 78|||Maximin 78|||AP01743|||AP01743 GIGGALLSVGKLALKGLANVLADKFAN Anti-Proteomics: Only active peptides with, activity value is MIC < 100 ug/ml||Anti-S. aureus ATCC 25923, activity value is MIC = 4.7 ug/ml||Anti-E.coli ATCC 25922, activity value is MIC > 100 ug/ml||Anti-and B. subtilis ATCC 6633, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans ATCC 20032, activity value is MIC = 37.5 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.7 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC > 100 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 37.5 ug/ml||Anti-Gram+||Antifungal||candidacidal brain, Bombina maxima, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima [Giant fire-bellied toad]|||brain, Bombina maxima, China, Asia|||brain, Bombina maxima, China, Asia N/A qevrn26xel98j4c9x0qa|||Human erythrocytes ( 40.6 % hemolysis at 125 ug/ml ), Rabiit erythrocytes ( 28.1 % hemolysis at 125 ug/ml )|||Human erythrocytes ( 40.6 % hemolysis at 125 ug/ml ), Rabiit erythrocytes ( 28.1 % hemolysis at 125 ug/ml )|||As listed in Table 5, the hemolytic activities of26 antimicrobial peptides with three different concentrations (0.0625, 0.125, and 250 ug/ml) against human and rabbit red cells were tested. They show stronger hemolytic activities against human red cells than rabbit red cells. The only exception is maximin H52. It is hemolytic ability to rabbit red cells is stronger than human red cells. But at a low concentration (62.5 ug/ml) of maximin H52, it induced 36.5 and 5% hemolysis ofhuman and rabbit red cells, respectively. Maximin 31, 39, 41, 42, and 77 and maximin H5, H23, H24, H27, H37, H46 and H54 have little hemolytic activity against rabbit red cells while only maximin H5, H25,|||HC50 ~125 ug/ml "J Proteome Res . 2011 Apr 1;10(4):1806-15. doi: 10.1021/pr101285n. Epub 2011 Mar 10.|||21338048|||21338048|||J Proteome Res. 2011 Apr 1;10(4):1806-15. PubMed|||J Proteome Res. 2011 Apr 1;10(4):1806-15. PubMed" 27 FPDB02601 AP01744|||DRAMP01129|||Maximin-H7|||AP01744|||DRAMP01129 ILGPVIKTIGGVIGGLLKNL Anti-Proteomics: Only active peptides with, activity value is MIC < 100 ug/ml||Anti-S. aureus ATCC 25923, activity value is MIC = 9.4 ug/ml||Anti-E.coli ATCC 25922, activity value is MIC > 100 ug/ml||Anti-and B. subtilis ATCC 6633, activity value is MIC = 18.8 ug/ml||Antimicrobial||Antibacterial||Antifungal||Antifungal ; C. albicans||Anti-Gram+||candidacidal brain, Bombina maxima, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||brain, Bombina maxima, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) N/A qevrn26xel98j4c9x0qa|||shows strong hemolytic activity|||As listed in Table 5, the hemolytic activities of26 antimicrobial peptides with three different concentrations (0.0625, 0.125, and 250 ug/ml) against human and rabbit red cells were tested. They show stronger hemolytic activities against human red cells than rabbit red cells. The only exception is maximin H52. It is hemolytic ability to rabbit red cells is stronger than human red cells. But at a low concentration (62.5 ug/ml) of maximin H52, it induced 36.5 and 5% hemolysis ofhuman and rabbit red cells, respectively. Maximin 31, 39, 41, 42, and 77 and maximin H5, H23, H24, H27, H37, H46 and H54 have little hemolytic activity against rabbit red cells while only maximin H5, H26,|||HC50 >125 ug/ml "J Proteome Res . 2011 Apr 1;10(4):1806-15. doi: 10.1021/pr101285n. Epub 2011 Mar 10.|||Eur J Immunol. 2005 Apr;35(4):1220-1229.|||J Proteome Res. 2011 Apr 1;10(4):1806-15. PubMed|||Eur J Immunol. 2005 Apr;35(4):1220-1229.|||J Proteome Res. 2011 Apr 1;10(4):1806-15. PubMed" 20 FPDB02606 AP01749|||Cc-CATH2|||Cc-CATH2|||AP01749|||AP01749 LVQRGRFGRFLKKVRRFIPKVIIAAQIGSRFG Anti-Gram+ S. aureus ATCC 2592, activity value is MIC = 0.3 uM||Anti-clinical strains, activity value is MIC = 20.2 uM||Anti-S. epidermidis, activity value is MIC = 2.5 uM||Anti-S. haemolyticus IS 2401 or DRa, activity value is MIC = 2.5 uM||Anti-E. faecalis IS981, activity value is MIC = 1.3 uM||Anti-E. faecium IS 1299, activity value is MIC = 2.5 uM||Anti-P. acnes, activity value is MIC = 1.3 uM||Anti-K. oxytoca, activity value is MIC = 2.5 uM||Anti-A. baumannii IS 2178 or Drb, activity value is MIC = 1.3 uM||Anti-A. baumannii IS 2373, activity value is MIC = 2.5 uM||Anti-S. maltophilia, activity value is MIC = 0.6||Anti-IS 1411-3, activity value is MIC = 10.1 uM||Anti-E. coli ATCC 27853 IS 1334-5, activity value is MIC = 1.3||Anti-K. pneumoniae IS strains, activity value is MIC = 1||Anti-P. vulgaris, activity value is MIC = 10.1 uM||Anti-S. typhi IS 1408, activity value is MIC = 5.1 uM||Anti-C. albicans ATCC 2002, activity value is MIC = 1.3 uM||Anti-C. glabrata IS 0902, activity value is MIC = 10.1 uM||Anti-and slime mold, activity value is MIC = 0.6 uM||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 0.3 uM||Anti-S. aureus, activity value is MIC = 1.3 uM||Anti-S. aureus, activity value is MIC = 20.2 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 2.5 uM||Anti-DRa, activity value is MIC = 2.5 uM||Anti-Nocardia asteroids, activity value is MIC = 1.3 uM||Anti-Enterococcus faecalis, activity value is MIC = 1.3 uM||Anti-Enterococcus faecium, activity value is MIC = 2.5 uM||Anti-Propionibacterium acnes ATCC 11827, activity value is MIC = 1.3 uM||Anti-Klebsiella oxytoca, activity value is MIC = 2.5 uM||Anti-Aeromonas sobria, activity value is MIC = 1.3 uM||Anti-DRb, activity value is MIC = 1.3 uM||Anti-A. baumannii, activity value is MIC = 2.5 uM||Anti-Stenotrophomonas maltophilia, activity value is MIC = 1.3 uM||Anti-S. maltophilia, activity value is MIC = 0.6 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 10.1 uM||Anti-P. aeruginosa, activity value is MIC = 10.1 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.5 uM||Anti-E. coli, activity value is MIC = 5.1 uM||Anti-E. coli, activity value is MIC = 2.5 uM||Anti-E. coli, activity value is MIC = 1.3 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 1.3 uM||Anti-K. pneumoniae, activity value is MIC = 2.5 uM||Anti-K. pneumoniae, activity value is MIC = 5.1 uM||Anti-Proteus vulgaris, activity value is MIC = 10.1 uM||Anti-Proteus mirabilis, activity value is MIC = 5.1 uM||Anti-Salmonella typhi, activity value is MIC = 5.1 uM||Anti-Candida albicans ATCC 2002, activity value is MIC = 1.3 uM||Anti-Candida glabrata, activity value is MIC = 10.1 uM||Anti-Slime mold, activity value is MIC = 0.6 uM||Anti-Gram+ & Gram- common quail, Coturnix coturnix|||Coturnix coturnix [Common quail]|||Coturnix coturnix [Common quail]|||common quail, Coturnix coturnix|||common quail, Coturnix coturnix N/A "In the study, hemolytic activity tests were conducted on two quail-derived antimicrobial peptides, Cc-CATH2 and Cc-CATH3, using freshly prepared human red blood cells. The specific values are as follows: - Cc-CATH2: At a concentration up to 26.9 μM (i.e., 100 μg/ml), the hemolysis rate of red blood cells was 3.6%; at a concentration of 50 μg/ml, the hemolysis rate was 0.0%; at a concentration of 20 μg/ml, the hemolysis rate was 0.0%; at a concentration of 10 μg/ml, the hemolysis rate was 0.0%. - Cc-CATH3: At a concentration up to 29.6 μM (i.e., 100 μg/ml), the hemolysis rate of red blood cells was 4.1%; at a concentration of 50 μg/ml, the hemolysis rate was 1.3%; at a concentration of 20 μg/ml, the hemolysis rate was 0.0%; at a concentration of 10 μg/ml, the hemolysis rate was 0.0%." "FEBS J . 2011 May;278(9):1573-84. doi: 10.1111/j.1742-4658.2011.08080.x. Epub 2011 Mar 25.|||21375690|||21375690|||FEBS J. 2011 May;278(9):1573-84. doi: 10.1111/j.1742-4658.2011.08080.x. PubMed|||FEBS J. 2011 May;278(9):1573-84. doi: 10.1111/j.1742-4658.2011.08080.x. PubMed" 32 FPDB02607 AP01750|||Cc-CATH3|||Cc-CATH3|||AP01750|||AP01750 RVRRFWPLVPVAINTVAAGINLYKAIRRK Anti-Gram+ S. aureus ATCC 2592, activity value is MIC = 0.2 uM||Anti-clinical strains, activity value is MIC = 0.7||Anti-N. asteroids, activity value is MIC = 0.7 uM||Anti-E. faecalis IS981, activity value is MIC = 5.6 uM||Anti-P. acnes, activity value is MIC = 1.4 uM||Anti-K. oxytoca, activity value is MIC = 22.2 uM||Anti-A. baumannii IS 2178 or Drb, activity value is MIC = 1.4 uM||Anti-A. baumannii IS 2373, activity value is MIC = 2.5 uM||Anti-S. maltophilia, activity value is MIC = 1.4||Anti-IS 1411-3, activity value is MIC = 5.6 uM||Anti-E. coli IS strains, activity value is MIC = 2.8||Anti-ONLY K. pneumoniae IS1400, activity value is MIC = 22.2 uM||Anti-P-vulgaris, activity value is MIC > 29.6 uM||Anti-P. mirabilis, activity value is MIC = 1.4 uM||Anti-C. albicans ATCC 2002, activity value is MIC = 0.7 uM||Anti-C. glabrata IS 0902, activity value is MIC = 5.6 uM||Anti-and slime mold, activity value is MIC = 0.7 uM||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 0.2 uM||Anti-S. aureus, activity value is MIC = 0.7 uM||Anti-S. aureus, activity value is MIC = 2.8 uM||Anti-DRa, activity value is MIC = 0.7 uM||Anti-Nocardia asteroids, activity value is MIC = 0.7 uM||Anti-Enterococcus faecalis, activity value is MIC = 5.6 uM||Anti-Enterococcus faecium, activity value is MIC = 1.4 uM||Anti-Propionibacterium acnes ATCC 11827, activity value is MIC = 1.4 uM||Anti-Klebsiella oxytoca, activity value is MIC = 22.2 uM||Anti-Aeromonas sobria, activity value is MIC = 1.4 uM||Anti-DRb, activity value is MIC = 1.4 uM||Anti-A. baumannii, activity value is MIC = 1.4 uM||Anti-Stenotrophomonas maltophilia, activity value is MIC = 1.4 uM||Anti-S. maltophilia, activity value is MIC = 5.6 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 5.6 uM||Anti-P. aeruginosa, activity value is MIC = 5.6 uM||Anti-E. coli, activity value is MIC = 11.1 uM||Anti-E. coli, activity value is MIC = 5.6 uM||Anti-E. coli, activity value is MIC = 2.8 uM||Anti-K. pneumoniae, activity value is MIC = 22.2 uM||Anti-Proteus mirabilis, activity value is MIC = 1.4 uM||Anti-Candida albicans ATCC 2002, activity value is MIC = 0.7 uM||Anti-Candida glabrata, activity value is MIC = 5.6 uM||Anti-Slime mold, activity value is MIC = 0.7 uM||Anti-Gram+ & Gram-||Antifungal common quail, Coturnix coturnix|||Coturnix coturnix [Common quail]|||Coturnix coturnix [Common quail]|||common quail, Coturnix coturnix|||common quail, Coturnix coturnix N/A "In the study, hemolytic activity tests were conducted on two quail-derived antimicrobial peptides, Cc-CATH2 and Cc-CATH3, using freshly prepared human red blood cells. The specific values are as follows: - Cc-CATH2: At a concentration up to 26.9 μM (i.e., 100 μg/ml), the hemolysis rate of red blood cells was 3.6%; at a concentration of 50 μg/ml, the hemolysis rate was 0.0%; at a concentration of 20 μg/ml, the hemolysis rate was 0.0%; at a concentration of 10 μg/ml, the hemolysis rate was 0.0%. - Cc-CATH3: At a concentration up to 29.6 μM (i.e., 100 μg/ml), the hemolysis rate of red blood cells was 4.1%; at a concentration of 50 μg/ml, the hemolysis rate was 1.3%; at a concentration of 20 μg/ml, the hemolysis rate was 0.0%; at a concentration of 10 μg/ml, the hemolysis rate was 0.0%." "FEBS J . 2011 May;278(9):1573-84. doi: 10.1111/j.1742-4658.2011.08080.x. Epub 2011 Mar 25.|||21375690|||21375690|||FEBS J. 2011 May;278(9):1573-84. doi: 10.1111/j.1742-4658.2011.08080.x. PubMed|||FEBS J. 2011 May;278(9):1573-84. doi: 10.1111/j.1742-4658.2011.08080.x. PubMed" 29 FPDB02608 AP01752|||Defensin-NV|||DRAMP03045|||AP01752|||AP01752 VTCELLMFGGVVGDSACAANCLSMGKAGGSCNGGLCDCRKTTFKELWDKRFG Anti-Gram+ & Gram-||Antifungal||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 0.93 uM||Anti-Bacillus cereus, activity value is MIC = 0.93 uM||Anti-B. dysenteriae, activity value is MIC = 0.46 uM||Anti-Escherichia coli, activity value is MIC = 1.86 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 9.3 uM the ectoparasitic wasp, onia vitripennis|||Nasonia vitripennis [Parasitic wasp]|||Nasonia vitripennis (Ectoparasitic wasp)|||the ectoparasitic wasp, onia vitripennis|||the ectoparasitic wasp, onia vitripennis Bridge Experimental results show that even at a defensin-NV concentration as high as 200,000 µg/ml (37,000 µM), the induced hemolysis rate is only 5%.|||Defensin-NV has an extremely low hemolytic activity against rabbit red blood cells, inducing only a 5% hemolysis rate even at a high concentration of 200 µg/ml (37 µM), using 1% Triton X-100-induced 100% hemolysis as a control. Toxicon. 2010 Aug 1;56(1):101-6|||20362606|||Toxicon. 2010 Aug 1;56(1):101-106.||Ref.20362606|||Toxicon. 2010 Aug 1;56(1):101-6|||Toxicon. 2010 Aug 1;56(1):101-6 52 FPDB02622 AP01769|||Piceain 1|||DRAMP00764|||Piceain 1|||AP01769|||DRAMP00764|||AP01769 KSLRPRCWIKIKFRCKSLKF Active against E. coli||P. aeruginosa||S. aureus||and fungus C. albicans.||Antibacterial ; Picea sitchensis [Sitka spruce]||Antibacterial||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 9.38 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 9.38 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 18.75 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 18.75 ug/ml||Anti-Escherichia coli 08040722, activity value is MIC = 75 ug/ml||Anti-Escherichia coli 08A866, activity value is MIC = 37.5 ug/ml||Anti-Pseudomonas aeruginosa PA01, activity value is MIC = 9.38 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 9.38 ug/ml||Anti-Pseudomonas aeruginosa 08031014, activity value is MIC = 37.5 ug/ml||Antifungal ; Escherichia coli||Pseudomonas aeruginosa||Staphylococcus aureus||Candida albicans||Bacillus subtilis||Anti-Gram+ & Gram-||Antifungal||candidacidal Picea sitchensis|||Picea sitchensis [Sitka spruce]|||Picea sitchensis Beta strand (CD) "In hemolysis experiments conducted on human and rabbit red blood cells, the hemolytic values of piceain 1 and 2 at different concentrations are as follows: - Piceain 1: At a concentration of 62.5 µg/ml, the hemolysis rate of human red blood cells was 0.7% and that of rabbit red blood cells was 1.5%; at 125 µg/ml, the hemolysis rate of human red blood cells was 0.8% and that of rabbit red blood cells was 7.2%; at 250 µg/ml, the hemolysis rate of human red blood cells was 5.9% and that of rabbit red blood cells was 7.8%; at 500 µg/ml, the hemolysis rate of human red blood cells was 7.6% and that of rabbit red blood cells was 9.5%; at 1000 µg/ml, the hemolysis rate of human red blood cells was 7.8% and that of rabbit red blood cells was 57.1%. - Piceain 2: At a concentration of 62.5 µg/ml, the hemolysis rate of human red blood cells was 0.6% and that of rabbit red blood cells was 2.2%; at 125 µg/ml, the hemolysis rate of human red blood cells was 0.8% and that of rabbit red blood cells was 4.7%; at 250 µg/ml, the hemolysis rate of human red blood cells was 5.2% and that of rabbit red blood cells was 5.2%; at 500 µg/ml, the hemolysis rate of human red blood cells was 5.3% and that of rabbit red blood cells was 12.4%; at 1000 µg/ml, the hemolysis rate of human red blood cells was 11.3% and that of rabbit red blood cells was 66.3%.|||For human red blood cells (HRC) and rabbit red blood cells (RRC), at a concentration of 62.5 ug/ml, the HRC hemolysis rate of Piceain-1 is 0.7%, RRC is 1.5%,Piceain-2 HRC is 0.6%, RRC is 2.2%; At a concentration of 125 ug/ml, the HRC of Piceain-1 is 0.8%, RRC is 7.2%,Piceain-2 HRC is 0.8%, RRC is 4.7%; when the concentration is 250 ug/ml, the HRC of Piceain-1 is 5.9, the RRC is 7.8, the HRC of Piceain-2 is 5.2, and the RRC is 5.2. When the concentration is 500 ug/ml, the HRC of Piceain-1 is 7.6, the RRC is 9.5, the HRC of Piceain-2 is 5.3, and the RRC is 12.4. When the concentration is 1000 ug/ml, piceain-1 has an HRC of 7.8 per cent and RRC of 57.1 per cent, while Piceain-2 has an HRC of 11.3 per cent and RRC of 66.3 per cent.|||[Ref.21644248] At the concentration of 62.5 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.7% & 1.5%; At the concentration of 125 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 7.2%; At the concentration of 250 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.9%&7.8%; At the concentration of 500 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 7.6% & 9.5%; At the concentration of 1000 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 7.8% & 57.1%.|||weak hemolysis activity" J Pept Sci. 2011 Sep;17(9):627-31|||https://pubmed.ncbi.nlm.nih.gov/21644248|||J Pept Sci. 2011 Sep;17(9):627-631.|||21644248|||J Pept Sci. 2011 Sep;17(9):627-31|||J Pept Sci. 2011 Sep;17(9):627-31 20 FPDB02623 AP01770|||DRAMP00765|||Piceain 2|||AP01770|||DRAMP00765 RPRCWIKIKFRCKSLKF Active against E. coli||P. aeruginosa||S. aureus||and fungus C. albicans.||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 9.38 ug/ml||Anti-S. aureus ATCC 43300, activity value is MIC = 18.75 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 37.5 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 37.5 ug/ml||Anti-Escherichia coli 08040722, activity value is MIC = 75 ug/ml||Anti-Escherichia coli 08A866, activity value is MIC = 37.5 ug/ml||Anti-Pseudomonas aeruginosa PA01, activity value is MIC = 9.38 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 18.75 ug/ml||Anti-Pseudomonas aeruginosa 08031014, activity value is MIC = 37.5 ug/ml||Antibacterial||Antifungal ; Escherichia coli||Pseudomonas aeruginosa||Staphylococcus aureus||Candida albicans||Bacillus subtilis||Anti-Gram+ & Gram-||Antifungal||candidacidal Picea sitchensis Beta "In hemolysis experiments conducted on human and rabbit red blood cells, the hemolytic values of piceain 1 and 2 at different concentrations are as follows: - Piceain 1: At a concentration of 62.5 µg/ml, the hemolysis rate of human red blood cells was 0.7% and that of rabbit red blood cells was 1.5%; at 125 µg/ml, the hemolysis rate of human red blood cells was 0.8% and that of rabbit red blood cells was 7.2%; at 250 µg/ml, the hemolysis rate of human red blood cells was 5.9% and that of rabbit red blood cells was 7.8%; at 500 µg/ml, the hemolysis rate of human red blood cells was 7.6% and that of rabbit red blood cells was 9.5%; at 1000 µg/ml, the hemolysis rate of human red blood cells was 7.8% and that of rabbit red blood cells was 57.1%. - Piceain 2: At a concentration of 62.5 µg/ml, the hemolysis rate of human red blood cells was 0.6% and that of rabbit red blood cells was 2.2%; at 125 µg/ml, the hemolysis rate of human red blood cells was 0.8% and that of rabbit red blood cells was 4.7%; at 250 µg/ml, the hemolysis rate of human red blood cells was 5.2% and that of rabbit red blood cells was 5.2%; at 500 µg/ml, the hemolysis rate of human red blood cells was 5.3% and that of rabbit red blood cells was 12.4%; at 1000 µg/ml, the hemolysis rate of human red blood cells was 11.3% and that of rabbit red blood cells was 66.3%.|||For human red blood cells (HRC) and rabbit red blood cells (RRC), at a concentration of 62.5 ug/ml, the HRC hemolysis rate of Piceain-1 is 0.7%, RRC is 1.5%,Piceain-2 HRC is 0.6%, RRC is 2.2%; At a concentration of 125 ug/ml, the HRC of Piceain-1 is 0.8%, RRC is 7.2%,Piceain-2 HRC is 0.8%, RRC is 4.7%; when the concentration is 250 ug/ml, the HRC of Piceain-1 is 5.9, the RRC is 7.8, the HRC of Piceain-2 is 5.2, and the RRC is 5.2. When the concentration is 500 ug/ml, the HRC of Piceain-1 is 7.6, the RRC is 9.5, the HRC of Piceain-2 is 5.3, and the RRC is 12.4. When the concentration is 1000 ug/ml, piceain-1 has an HRC of 7.8 per cent and RRC of 57.1 per cent, while Piceain-2 has an HRC of 11.3 per cent and RRC of 66.3 per cent.|||[Ref.21644248] At the concentration of 62.5 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.6% & 2.2%; At the concentration of 125 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 4.7%; At the concentration of 250 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.2%&5.2%; At the concentration of 500 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.3% & 12.4%; At the concentration of 1000 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 11.3% & 66.3%.|||[Ref.21644248] At the concentration of 62.5 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.6% & 2.2%; At the concentration of 125 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 4.7%; At the concentration of 250 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.2%&5.2%; At the concentration of 500 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.3% & 12.4%; At the concentration of 1000 ug/ml, Piceain 1 induced human & rabbit red cell hemolysis of 11.3% & 66.3%." J Pept Sci. 2011 Sep;17(9):627-31|||J Pept Sci. 2011 Sep;17(9):627-631.|||21644248|||J Pept Sci. 2011 Sep;17(9):627-31 17 FPDB02625 AP01778|||Jindongenin-1a|||DRAMP01849|||Jindongenin-1a|||AP01778|||DRAMP01849|||AP01778 DSMGAVKLAKLLIDKMKCEVTKAC Anti-Gram+ S. aureus ATCC25923, activity value is MIC = 17 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 60 uM||Anti-S. aureus IS 10#, activity value is MIC = 40 uM||Anti-S.aureus IS 37#, activity value is MIC > 200 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 10 uM||Anti-E. coli, activity value is MIC = 60 uM||Anti-E.coli IS 117#, activity value is MIC > 200 ug/ml||Anti-E.coli IS 218#, activity value is MIC > 200 ug/ml||Anti-E. cloacae ATCC13047, activity value is MIC = 40 uM||Anti-K. pneumonia ATCC700603, activity value is MIC = 15 uM||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 17 uM||Anti-B. dysenteriae, activity value is MIC = 40 uM||Anti-P. aeruginosa IS 350#, activity value is MIC = 23 uM||Anti-K. pneumonia IS 59#, activity value is MIC = 30 uM||Anti-C. albicans ATCC2002, activity value is MIC = 60 uM||Anti-C.albicans ATCC2002, activity value is MIC > 200 ug/ml||Anti-and C. albicans ATCC2002 (MIC, activity value is MIC > 200 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 17 uM||Anti-Enterococcus faecalis ATCC29212, activity value is MIC = 60 uM||Anti-Staphylococcus aureus, activity value is MIC = 40 uM||Anti-Escherichia coli ATCC25922, activity value is MIC = 10 uM||Anti-Enterobacter cloacae ATCC13047, activity value is MIC = 40 uM||Anti-Klebsiella pneumoniae ATCC700603, activity value is MIC = 15 uM||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 17 uM||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 23 uM||Anti-Bacillus dysenteriae, activity value is MIC = 40 uM||Anti-Candida albicans ATCC2002, activity value is MIC = 60 uM||Anti-Klebsiella pneumonia ATCC700603, activity value is MIC = 15 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 23 uM||Anti-Klebsiella pneumonia, activity value is MIC = 30 uM||Anti-E. coli IS 37#, activity value is MIC = 60 uM||Anti-E.coli IS 117# or 218#, activity value is MIC > 200 ug/ml||Anti-P. aeruginosa ATCC27853 or IS 350#, activity value is MIC = 23 uM||Anti-Gram+ & Gram-||candidacidal the Chinese torrent frog, Amolops jingdongensis, Asia|||Amolops jingdongensis [Chinese torrent frog]|||Amolops jingdongensis (Chinese torrent frog)|||Amolops jingdongensis [Chinese torrent frog]|||the Chinese torrent frog, Amolops jingdongensis, Asia|||Amolops jingdongensis (Chinese torrent frog)|||the Chinese torrent frog, Amolops jingdongensis, Asia N/A "This study analyzed two antimicrobial peptides (AMPs) from the skin secretions of the Chinese Jingdong torrent frog and tested their hemolytic activity, with the values as follows: - Jindongenin-1a showed slight hemolytic activity against washed human and rabbit red blood cells, with an average IC_{50} value of 150 μM. - Palustrin-2AJ1 showed slight hemolytic activity against washed human and rabbit red blood cells, with an average IC_{50} value of 135 μM.|||Staphylococcus aureus ATCC25923 ( MIC = 17 uM ), Enterococcus faecalis ATCC29212 ( MIC = 60 uM ), Staphylococcus aureus (IS 10) ( MIC = 40 uM ), Escherichia coli ATCC25922 ( MIC = 10 uM ), Enterobacter cloacae ATCC13047 ( MIC = 40 uM ), Klebsiella pneumonia ATCC700603 ( MIC = 15 uM ), Bacillus pyocyaneus CMCCB1010 ( MIC = 17 uM ), Pseudomonas aeruginosa ATCC27853 ( MIC = 23 uM ), Bacillus dysenteriae ( MIC = 40 uM ), E. coli (IS 37)( MIC = 60 uM ), Pseudomonas aeruginosa (IS 350)( MIC = 23 uM ), Klebsiella pneumonia (IS 59) ( MIC = 30 uM ), Candida albicans ATCC2002 ( MIC = 60 uM )|||In Biochimie 2012, jindongenin-1a and palustrin-2AJ1, isolated from the skin secretions of Jingdong torrent frog (Amolops jingdongensis), showed weak hemolytic activity against human and rabbit red blood cells, with average IC₅₀ values of 150 μM and 135 μM, respectively.|||[Ref.21816202] IC50=150 uM against washed human erythrocytes|||[Ref.21816202] IC50=150 uM against washed human erythrocytes" "Biochimie . 2012 Feb;94(2):328-34. doi: 10.1016/j.biochi.2011.07.021. Epub 2011 Jul 24.|||21816202|||Biochimie. 2012 Feb;94(2):328-334.||Ref.21816202|||21816202||Ref.21816202|||21816202|||Biochimie. 2012 Feb;94(2):328-34.PubMed.|||Ref.21816202|||Biochimie. 2012 Feb;94(2):328-34.PubMed." 24 FPDB02627 AP01781|||DRAMP01232|||DRAMP01233 GFMDTAKNVAKNVAATLLDKLKCKITGGC Anti-Gram- bacteria E. coli, activity value is MIC = 14.5 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 14.5 ug/ml||Anti-S. aureus, activity value is MIC = 7.3 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 14.5 ug/ml||Anti-MRSA, activity value is MIC > 100 uM||Anti-B. subtilis, activity value is MIC = 12.5 uM||Anti-and C.albicans, activity value is MIC > 100 uM||Anti-Escherichia coli, activity value is MIC = 100 uM||Anti-Staphylococcus aureus, activity value is MIC = 25 uM||Anti-Bacillus subtilis, activity value is MIC = 12.5 uM||Anti-Escherichia coli, activity value is MIC = 120 uM||Anti-Gram+ & Gram-||Antifungal Odorrana ishikawae, Japan; Odorrana wuchuanensis, China, Asia. skin secretion, the Wuyi torrent frog, Amolops wuyiensis, UK market|||Odorrana ishikawae (Ishikawa's frog)|||Rana palustris (Pickerel frog) N/A N/A "Biochem Biophys Res Commun . 2011 Sep 9;412(4):673-7. doi: 10.1016/j.bbrc.2011.08.023. Epub 2011 Aug 16.|||Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-7. PubMed." 29 FPDB02628 AP01786|||Lycocitin-1|||DRAMP03253|||Lycocitin-1|||AP01786|||AP01786 GKLQAFLAKMKEIAAQTL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-B. subtilis ATCC6633, activity value is MIC = 1||Anti-E. coli ATCC25922, activity value is MIC = 3||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 1.6||Anti-Escherichia coli ATCC25922, activity value is MIC = 3.2 venom glands, the wolf spider, Lycosa singoriensis|||Lycosa singoriensis [Wolf spider]|||Lycosa singoriensis (Wolf spider) (Aranea singoriensis)|||venom glands, the wolf spider, Lycosa singoriensis, Europe|||venom glands, the wolf spider, Lycosa singoriensis, Europe N/A N/A J Mass Spectrom. 2004 Feb;39(2):193-201.|||14991689|||J Mass Spectrom. 2004 Feb;39(2):193-201. 18 FPDB02629 AP01787|||Lycocitin-2|||DRAMP03254|||Lycocitin-2|||AP01787|||AP01787 GRLQAFLAKMKEIAAQTL Anti-Gram+ & Gram-||Antifungal||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 1.57||Anti-Escherichia coli ATCC25922, activity value is MIC = 3.14||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 5.02 venom glands, the wolf spider, Lycosa singoriensis|||Lycosa singoriensis [Wolf spider]|||Lycosa singoriensis (Wolf spider) (Aranea singoriensis)|||venom glands, the wolf spider, Lycosa singoriensis , Europe|||venom glands, the wolf spider, Lycosa singoriensis , Europe N/A N/A J Mass Spectrom. 2004 Feb;39(2):193-201.|||14991689|||J Mass Spectrom. 2004 Feb;39(2):193-201. 18 FPDB02632 AP01790|||Myticin-B|||DRAMP02809|||Myticin-B|||AP01790 HPHVCTSYYCSKFCGTAGCTRYGCRNLHRGKLCFCLHCSR Anti-Gram+ & Gram-||Antifungal||Antibacterial||Anti-Micrococcus luteus, activity value is MBC = 1||Anti-Bacillus megaterium, activity value is MBC = 1||Anti-Aerococcus viridans, activity value is MBC = 2||Anti-Micrococcus luteus, activity value is MIC = 1||Anti-Bacillus megaterium, activity value is MIC = 1||Anti-Enterococcus viridans, activity value is MIC = 2||Anti-Escherichia coli D31, activity value is MIC = 120||Anti-Salmonella newport, activity value is MIC = 120||Anti-Fusarium oxysporum, activity value is MIC = 5 hemocytes, the mediterranean mussel, Mytilus galloprovincialis|||Mytilus galloprovincialis [Mediterranean mussel]|||Mytilus galloprovincialis (Mediterranean mussel)|||Mytilus galloprovincialis [Mediterranean mussel]|||hemocytes, the mediterranean mussel, Mytilus galloprovincialis N/A N/A "Eur J Biochem . 1999 Oct 1;265(1):71-8. doi: 10.1046/j.1432-1327.1999.00654.x.|||10491159|||Mol Cell Proteomics. 2007 May;6(5):882-894.|||10491159|||Eur J Biochem. 1999 Oct 1;265(1):71-8. PubMed." 40 FPDB02644 AP01815|||HIMS-Defensin|||DRAMP02423|||AP01815|||AP01815 DFGCARGMIFVCMRRCARMYPGSTGYCQGFRCMCDTMIPIRRPPFIMG Anti-Gram+ & Gram-||Antifungal||Antibacterial||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 18.8 ug/ml||Anti-Bacillus licheniformis, activity value is MIC = 9.4 ug/ml||Anti-Escherichia coli ATCC25922, activity value is MIC = 28.1 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 37.5 ug/ml||Anti-Serratia rubidaea, activity value is MIC = 28.1 ug/ml||Anti-Psychrobacter faecalis, activity value is MIC = 2.3 ug/ml the tick, Haemaphysalis longicornis|||Haemaphysalis longicornis [Bush tick]|||Haemaphysalis longicornis (Tick)|||the tick, Haemaphysalis longicornis|||the tick, Haemaphysalis longicornis Bridge N/A "Dev Comp Immunol . 2012 May;37(1):207-11. doi: 10.1016/j.dci.2011.10.004. Epub 2011 Oct 19.|||22033149|||Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76.|||Dev Comp Immunol . 2012 May;37(1):207-11. doi: 10.1016/j.dci.2011.10.004. Epub 2011 Oct 19.|||Dev Comp Immunol. 2012 May;37(1):207-11. PubMed." 48 FPDB02645 AP01820|||Brevinin-1-OA1|||DRAMP02038|||Brevinin-1-OA1|||AP01820|||AP01820 VIVFVASVAAEMMQHVYCAASKKC Anti-Gram- bacteria E. coli, activity value is MIC = 6.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 12.4 ug/ml||Anti-S. aureus, activity value is MIC = 12.4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 24.8 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.4 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 12.4 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 24.8 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana andersonii, China, Asia N/A "Escherichia coli ATCC 25922 ( MIC = 6.2 ug/ml ), Candida albicans ATCC 2002 ( MIC = 24.8 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 12.4 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 12.4 ug/ml )|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 4)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed" 24 FPDB02646 AP01821|||DRAMP01193|||AP01821|||DRAMP01193 FLPKLFAGIISKNF Anti-Gram- bacteria E. coli, activity value is MIC = 10.5 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 10.5 ug/ml||Anti-S. aureus, activity value is MIC = 21 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 5.3 ug/ml||Antimicrobial||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Golden crossband frog) N/A "Conclusion: Among the 23 synthetic peptides, only Andersonin-C1 exhibited detectable hemolytic activity (about 15% hemolysis at 50 µg/ml). The remaining 22 synthetic peptides showed no hemolytic activity under the same conditions. The naturally purified peptides were not subjected to hemolysis testing, so no related data are available.|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 5)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed" 14 FPDB02647 AP01822|||DRAMP02040|||AP01822 FLPAVIRVAANVLPTAFCAISKKC Anti-Gram- bacteria E. coli, activity value is MIC = 6.6 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 13.2 ug/ml||Anti-S. aureus, activity value is MIC = 6.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 3.3 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 13.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 6)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 24 FPDB02648 AP01823|||DRAMP02041|||AP01823 LPFVAGVAAEMMQHVYCAASKKC Anti-Gram- bacteria E. coli, activity value is MIC = 5.3 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 42.4 ug/ml||Anti-S. aureus, activity value is MIC = 10.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 10.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5.3 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 42.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10.6 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana rotodora, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 7)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 23 FPDB02649 AP01824|||Andersonin-Y1|||AY1|||DRAMP01192|||Andersonin-Y1|||AP01824|||DRAMP01192|||AP01824 FLPKLFAKITKKNMAHIR Anti-Gram- bacteria E. coli, activity value is MIC = 3.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 3.2 ug/ml||Anti-S. aureus, activity value is MIC = 1.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 1.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 3.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 1.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 1.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 3.2 ug/ml||P. aeruginosa (MIC=~50 uM)||E. coli (MIC= ~50 uM)||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii [Golden crossband frog]|||Synthetic construct|||Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii, China, Asia Helix "[Ref:22029824]Not found|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 8).|||[Ref:22029824]Not found" "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.||Pal et al. 2019|||22029824|||30872680|||J Proteome Res. 2012 Jan 1;11(1):306-319||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.||Pal et al. 2019|||Ref.22029824|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 18 FPDB02650 AP01825|||Brevinin-1-OR3|||DRAMP02042|||Brevinin-1-OR3|||AP01825|||AP01825 IDPFVAGVAAEMMQHVYCAASKKC Anti-Gram- bacteria E. coli, activity value is MIC = 9.1 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 18.2 ug/ml||Anti-S. aureus, activity value is MIC = 18.2 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 18.2 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 9.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 18.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 18.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 18.2 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Escherichia coli ATCC 25922 ( MIC = 9.1 ug/ml ), Candida albicans ATCC 2002 ( MIC = 18.2 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 18.2 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 18.2 ug/ml )|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 9)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 24 FPDB02651 AP01826|||Brevinin-1-OR4|||DRAMP02043|||Brevinin-1-OR4|||AP01826|||AP01826 INPFVAGVAAEMMQHVYCAASKKC Anti-Active against Gram- bacteria E. coli, activity value is MIC = 8.6 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 8.6 ug/ml||Anti-S. aureus, activity value is MIC = 8.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 8.6 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 8.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 8.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 8.6 ug/ml||Anti-Gram- bacteria E. coli, activity value is MIC = 8.6 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Escherichia coli ATCC 25922 ( MIC = 8.6 ug/ml ), Candida albicans ATCC 2002 ( MIC = 8.6 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 8.6 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 8.6 ug/ml )|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 10)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 24 FPDB02652 AP01827|||Brevinin-1-OR5|||DRAMP02044|||Brevinin-1-OR5|||AP01827|||AP01827 ILPFVAGVAAEMMKHVYCAASKKC Anti-Gram- bacteria E. coli, activity value is MIC = 15.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 30.4 ug/ml||Anti-S. aureus, activity value is MIC = 15.2 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 7.6 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 15.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 30.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 15.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 7.6 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Escherichia coli ATCC 25922 ( MIC = 15.2 ug/ml ), Candida albicans ATCC 2002 ( MIC = 7.6 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 15.2 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 30.4 ug/ml )|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 11)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 24 FPDB02653 AP01828|||Brevinin-1-OR6|||DRAMP02045|||Brevinin-1-OR6|||AP01828|||AP01828 IIPFVAGVAAEMMEHVYCAASKKC Anti-Gram- bacteria E. coli, activity value is MIC = 11.1 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 22.2 ug/ml||Anti-S. aureus, activity value is MIC = 22.2 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 11.1 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 11.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 22.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 22.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 11.1 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Escherichia coli ATCC 25922 ( MIC = 11.1 ug/ml ), Candida albicans ATCC 2002 ( MIC = 11.1 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 22.2 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 22.2 ug/ml )|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 12)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 19.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed" 24 FPDB02654 AP01829|||Brevinin-1-OR7|||DRAMP02046|||Brevinin-1-OR7|||AP01829|||AP01829 QLPFVAGVACEMCQCVYCAASKKC Anti-Gram- bacteria E. coli, activity value is MIC = 5.7 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 5.7 ug/ml||Anti-S. aureus, activity value is MIC = 11.4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 11.4 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5.7 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 5.7 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 11.4 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 11.4 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Escherichia coli ATCC 25922 ( MIC = 5.7 ug/ml ), Candida albicans ATCC 2002 ( MIC = 11.4 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 11.4 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 5.7 ug/ml )|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 13)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 20.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 24 FPDB02655 AP01830|||Brevinin-1-OR8|||DRAMP02047|||Brevinin-1-OR8|||AP01830|||AP01830 ILPFVAGVAAEMMEHVYCAASKKC Anti-Gram- bacteria E. coli, activity value is MIC = 13.1 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 52.4 ug/ml||Anti-S. aureus, activity value is MIC = 26.2 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 13.1 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 13.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 52.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 26.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 13.1 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Escherichia coli ATCC 25922 ( MIC = 13.1 ug/ml ), Candida albicans ATCC 2002 ( MIC = 13.1 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 26.2 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 52.4 ug/ml )|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 14)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 21.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 24 FPDB02656 AP01831|||Brevinin-1-OR9|||DRAMP02048|||Brevinin-1-OR9|||AP01831|||AP01831 ILPFVAGVAAMEMEHVYCAASKKC Anti-Gram- bacteria E. coli, activity value is MIC = 9.8 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 9.8 ug/ml||Anti-S. aureus, activity value is MIC = 4.9 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 9.8 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 9.8 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 9.8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.9 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 9.8 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Escherichia coli ATCC 25922 ( MIC = 9.8 ug/ml ), Candida albicans ATCC 2002 ( MIC = 9.8 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 4.9 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 9.8 ug/ml )|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 15)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 22.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 24 FPDB02657 AP01832|||Brevinin-1-OR10|||DRAMP02049|||Brevinin-1-OR10|||AP01832|||AP01832 FLPAVLLVATHVLPTVFCAITRKC Anti-Gram- bacteria E. coli, activity value is MIC = 3.4 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 27.2 ug/ml||Anti-S. aureus, activity value is MIC = 6.8 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 6.8 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 3.4 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 27.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.8 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 6.8 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Escherichia coli ATCC 25922 ( MIC = 3.4 ug/ml ), Candida albicans ATCC 2002 ( MIC = 6.8 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 6.8 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 27.2 ug/ml )|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 16)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 23.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 24 FPDB02658 AP01833|||Brevinin-1-OR11|||DRAMP02050|||Brevinin-1-OR11|||AP01833|||AP01833 LAFVAGVAAEMMQHVYCAASKKC Anti-Gram- bacteria E. coli, activity value is MIC = 6.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 12.4 ug/ml||Anti-S. aureus, activity value is MIC = 12.4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 12.4 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 12.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.4 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 12.4 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Escherichia coli ATCC 25922 ( MIC = 6.2 ug/ml ), Candida albicans ATCC 2002 ( MIC = 12.4 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 12.4 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 12.4 ug/ml )|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 17)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 24.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 23 FPDB02659 AP01834|||Brevinin-2-OA1|||DRAMP02054|||Brevinin-2-OA1|||AP01834|||AP01834 GILDTFKNMALNAAKSAGVSVLNALSCKLSKTC Anti-Gram- bacteria E. coli, activity value is MIC = 12.1 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 12.1 ug/ml||Anti-S. aureus, activity value is MIC = 12.1 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 6 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 12.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 12.1 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.1 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 6 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana andersonii, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 18)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 25.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02660 AP01835|||DRAMP02055|||AP01835 GLLDTFKNMALNAAKSAGVSVLNALSCKLSKTC Anti-Gram- bacteria E. coli, activity value is MIC = 13.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 6.6 ug/ml||Anti-S. aureus, activity value is MIC = 6.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 6.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 13.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 6.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.6 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii; Odorrana grahami, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii; Odorrana grahami, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 19)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 26.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02661 AP01836|||Brevinin-2-OA3|||DRAMP02056|||Brevinin-2-OA3|||AP01836|||AP01836 GLLDTFKNMAINAAHGAGVSVLNALSCKLKKTC Anti-Gram- bacteria E. coli, activity value is MIC = 6.3 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 12.6 ug/ml||Anti-S. aureus, activity value is MIC = 6.3 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 3.2 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.3 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 12.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.3 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3.2 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana andersonii, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 20)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 27.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02662 AP01837|||Brevinin-2-OA4|||DRAMP02057|||Brevinin-2-OA4|||AP01837|||AP01837 GLLDTFKNLAINAAESAGVSVLNSLSCKLSKTC Anti-Gram- bacteria E. coli, activity value is MIC = 20 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 20 ug/ml||Anti-S. aureus, activity value is MIC = 10 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 10 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 20 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 10 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana andersonii, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 21)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 28.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 19.PubMed." 33 FPDB02663 AP01838|||Brevinin-2-OA5|||DRAMP02058|||Brevinin-2-OA5|||AP01838|||AP01838 GLLDGILNANFNAAKSAGTSVLNALSCKLSKTC Anti-Gram- bacteria E. coli, activity value is MIC = 30.6 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 30.6 ug/ml||Anti-S. aureus, activity value is MIC = 30.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 30.6 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 30.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 30.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 30.6 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana andersonii, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 22)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 29.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02664 AP01839|||Brevinin-2-OA6|||DRAMP02059|||Brevinin-2-OA6|||AP01839|||AP01839 GVLATVKNLLIGTGDGAAQSVLKTLSCKLSNDC Anti-Active against Gram- bacteria E. coli, activity value is MIC = 11.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 44.8 ug/ml||Anti-S. aureus, activity value is MIC = 22.4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 11.2 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 11.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 44.8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 22.4 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 11.2 ug/ml||Anti-Gram- bacteria E. coli, activity value is MIC = 11.2 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana andersonii, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 23)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 30.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02665 AP01840|||Brevinin-2-OA7|||DRAMP02060|||Brevinin-2-OA7|||AP01840|||AP01840 GVLGTVKDLLIGAGKSAAQSTLKTLSCKISNDC Anti-Gram- bacteria E. coli, activity value is MIC = 5.8 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 23.2 ug/ml||Anti-S. aureus, activity value is MIC = 11.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 5.8 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5.8 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 23.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 11.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 5.8 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana andersonii, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 24)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 31.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02666 AP01841|||Brevinin-2-OA8|||DRAMP02061|||Brevinin-2-OA8|||AP01841|||AP01841 GVLATVKNLLNGTGDGAAQSVLKTLSCKLSNDC Anti-Gram- bacteria E. coli, activity value is MIC = 7.9 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 15.8 ug/ml||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 4 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 7.9 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 15.8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 4 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana andersonii, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 25)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 32.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02667 AP01842|||Andersonin-D1|||DRAMP01195|||Andersonin-D1|||AP01842|||DRAMP01195|||AP01842 FIFPKKNIINSLFGR Anti-Gram- bacteria E.coli, activity value is MIC > 126 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 16 ug/ml||Anti-S. aureus, activity value is MIC = 16 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 16 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC > 126 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 16 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 16 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||anti-diabetes sequence homology|||Odorrana andersonii|||Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii [Golden crossband frog]|||sequence homology|||Odorrana andersonii (Golden crossband frog)|||sequence homology N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 26)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 33.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 15 FPDB02668 AP01843|||Brevinin-2-OR2|||DRAMP02062|||Brevinin-2-OR2|||AP01843|||AP01843 GLLDTIKNMALNAAKSAGVSVLNSLSCKLSKTC Anti-Gram- bacteria E. coli, activity value is MIC = 12.1 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 6 ug/ml||Anti-S. aureus, activity value is MIC = 12.1 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 12.1 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 12.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.1 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 12.1 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 27)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 34.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02669 AP01844|||Brevinin-2-OR3|||DRAMP02063|||Brevinin-2-OR3|||AP01844|||AP01844 GLIDTIKNMALNAAKSAGVSVLNTLSCKLSKTC Anti-Gram- bacteria E. coli, activity value is MIC = 20.6 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 41.2 ug/ml||Anti-S. aureus, activity value is MIC = 20.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 10.3 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 20.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 41.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 20.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 10.3 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 28)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 35.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02670 AP01845|||Brevinin-2-OR4|||DRAMP02064|||Brevinin-2-OR4|||AP01845|||AP01845 " SVLGTVKDLLIGAGKSAAQSVLTANSCKLSNSC" Anti-Gram- bacteria E. coli, activity value is MIC = 11.8 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 11.8 ug/ml||Anti-S. aureus, activity value is MIC = 5.9 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 11.8 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 11.8 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 11.8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5.9 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 11.8 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 29)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 36.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02671 AP01846|||Brevinin-2-OR5|||DRAMP02065|||Brevinin-2-OR5|||AP01846|||AP01846 SFLDTLKNLAISAAKGAGQSVLSTLSCKLSETC Anti-Gram- bacteria E. coli, activity value is MIC = 13.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 6.6 ug/ml||Anti-S. aureus, activity value is MIC = 6.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 6.6 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 13.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 6.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 6.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.6 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 30)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 37.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02672 AP01847|||Brevinin-2-OR6|||DRAMP02066|||Brevinin-2-OR6|||AP01847|||AP01847 GLLDTIKNMALNAAKSAGVSVLNSLSCKDSKTC Anti-Gram- bacteria E. coli, activity value is MIC = 5.8 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 11.6 ug/ml||Anti-S. aureus, activity value is MIC = 5.8 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 11.6 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5.8 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 11.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 11.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5.8 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 31)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 38.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02673 AP01848|||Brevinin-2-OR7|||DRAMP02067|||Brevinin-2-OR7|||AP01848|||AP01848 GLLDTIKNMALNAAKSAGVSVLNTLSCKLSKTC Anti-Gram- bacteria E. coli, activity value is MIC = 8.6 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 8.6 ug/ml||Anti-S. aureus, activity value is MIC = 8.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 17.2 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 8.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 17.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 8.6 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 32)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 39.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02674 AP01849|||Andersonin-C1|||DRAMP01194|||Andersonin-C1|||AP01849|||DRAMP01194|||AP01849 TSRCIFYRRKKCS Anti-Gram- bacteria E. coli, activity value is MIC = 30 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 30 ug/ml||Anti-S.aureus, activity value is MIC > 120 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 30 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 30 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 120 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 30 ug/ml||Antibacterial||Antifungal||Anti-Gram-||candidacidal||anti-diabetes||Hemolytic sequence homology|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii [Golden crossband frog]|||sequence homology|||Odorrana andersonii (Golden crossband frog)|||sequence homology N/A "Human erythrocytes ( 15.2±2.1% hemolysis ) at 50 ug/ml|||[Ref:22029824] It has 15.2±2.1% hemolytic activity at 50 ug/ml against human red blood cells|||Human erythrocytes ( 15.2�±2.1% hemolysis ) at 50 ug/ml|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 33).|||[Ref:22029824] It has 15.2±2.1% hemolytic activity at 50 ug/ml against human red blood cells" "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 40.|||Ref.22029824|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 13 FPDB02675 AP01850|||Brevinin-2-OR9|||DRAMP02068|||Brevinin-2-OR9|||AP01850|||AP01850 SFLSTFKELAINAAKNAGQSILHTLSCKLDKTC Anti-Gram- bacteria E. coli, activity value is MIC = 20.4 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 20.4 ug/ml||Anti-S. aureus, activity value is MIC = 10.2 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 5.1 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 20.4 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 20.4 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 5.1 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10.2 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 34)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 41.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02676 AP01851|||Brevinin-2-OR10|||DRAMP02069|||Brevinin-2-OR10|||AP01851|||AP01851 SFLSTFKELAINAAKNAGQSLLHTLSCKLDKTC Anti-Gram- bacteria E. coli, activity value is MIC = 15.8 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 7.9 ug/ml||Anti-S. aureus, activity value is MIC = 7.9 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 15.8 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 15.8 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 7.9 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 15.8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 7.9 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora, China, Asia|||Odorrana rotodora|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 35)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 42.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02677 AP01852|||Brevinin-2-OW1|||DRAMP02070|||Brevinin-2-OW1|||AP01852|||AP01852 SVMGTVKDLLIGAGKSAAQSVLKSLSCKISNDC Anti-Gram- bacteria E. coli, activity value is MIC = 4.7 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 4.7 ug/ml||Anti-S. aureus, activity value is MIC = 9.4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 4.7 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 4.7 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 4.7 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 4.7 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 9.4 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana wuchuanensis, China, Asia|||Odorrana wuchuanensis|||Odorrana andersonii (Chinese odorous frog)|||Odorrana wuchuanensis|||Odorrana wuchuanensis, China, Asia|||Odorrana wuchuanensis, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 36)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 43.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02678 AP01853|||Brevinin-2-OW2|||DRAMP02071|||Brevinin-2-OW2|||AP01853|||AP01853 SVMGTVKDLLIGAGKSAAQSVLKSLSCKLSNDC Anti-Gram- bacteria E. coli, activity value is MIC = 6.6 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 6.6 ug/ml||Anti-S. aureus, activity value is MIC = 3.3 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 3.3 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 6.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3.3 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.3 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana wuchuanensis, China, Asia|||Odorrana wuchuanensis|||Odorrana andersonii (Chinese odorous frog)|||Odorrana wuchuanensis|||Odorrana wuchuanensis, China, Asia|||Odorrana wuchuanensis, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 37)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 44.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02679 AP01854|||Brevinin-2-OW3|||DRAMP02072|||Brevinin-2-OW3|||AP01854|||AP01854 SVMGTVKDLLIGAGKSAAQSVLKALSCKLSKDC Anti-Gram- bacteria E. coli, activity value is MIC = 10.5 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 21 ug/ml||Anti-S. aureus, activity value is MIC = 10.5 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 10.5 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 10.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 21 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 10.5 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10.5 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana wuchuanensis, China, Asia|||Odorrana wuchuanensis|||Odorrana andersonii (Chinese odorous frog)|||Odorrana wuchuanensis|||Odorrana wuchuanensis, China, Asia|||Odorrana wuchuanensis, China, Asia N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 38)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 45.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 33 FPDB02680 AP01855|||DRAMP01493|||AP01855|||DRAMP01493 GLFSKFVGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC Anti-Gram- bacteria E. coli, activity value is MIC = 1.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 1.2 ug/ml||Anti-S. aureus, activity value is MIC = 1.2 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 2.4 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 1.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 1.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Chinese odorous frog) N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 39)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 46.|||Gram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=1.2 ug/ml), Staphylococcus aureus ATCC 25923 (MIC=1.2 ug/ml). Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.2 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=2.4 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 46 FPDB02681 AP01856|||DRAMP01494|||AP01856|||DRAMP01494 GLFSKFSGKGIKNFLIKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC Anti-Gram- bacteria E. coli, activity value is MIC = 2.5 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 2.5 ug/ml||Anti-S. aureus, activity value is MIC = 1.3 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 1.3 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 2.5 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 1.3 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Chinese odorous frog) N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 40)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 47.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.5 ug/ml); Gram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=2.5 ug/ml), Staphylococcus aureus ATCC 25923 (MIC=1.3 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=1.3 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 46 FPDB02682 AP01857|||DRAMP01495|||AP01857|||DRAMP01495 GLFSKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC Anti-Gram- bacteria E. coli, activity value is MIC = 5.4 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 2.7 ug/ml||Anti-S. aureus, activity value is MIC = 5.4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 2.7 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5.4 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 2.7 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Chinese odorous frog) N/A "Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 41)." "J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 48.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.4 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=5.4 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=2.7 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=2.7 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 46 FPDB02683 AP01858|||DRAMP01496|||AP01858|||DRAMP01496 GLFTKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC Anti-Gram- bacteria E. coli, activity value is MIC = 5.6 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 2.8 ug/ml||Anti-S. aureus, activity value is MIC = 2.8 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 5.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2.8 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 2.8 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 42)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 49.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.6 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2.8 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=2.8 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=5.6 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 46 FPDB02684 AP01859|||DRAMP01497|||AP01859|||DRAMP01497 GLFSKFAGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC Anti-Gram- bacteria E. coli, activity value is MIC = 3.4 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 3.4 ug/ml||Anti-S. aureus, activity value is MIC = 1.7 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 1.7 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 3.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 1.7 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 3.4 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 43)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 50.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.4 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1.7 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=3.4 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=1.7 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 18.PubMed." 46 FPDB02685 AP01860|||DRAMP01189|||DRAMP01190|||Andersonin-W1|||AP01860|||DRAMP01189 ATNIPFKVHFRCKAAFC Anti-E. coli, activity value is MIC = 23.5 ug/ml||Anti-C. albicans, activity value is MIC = 47 ug/ml||Anti-S-aureus, activity value is MIC > 47 ug/ml||Anti-and B-pyocyaneus, activity value is MIC > 47 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 23.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC > 47 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 47 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 47 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 20.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 40.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10.1 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 20.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Wound healing Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||[Ref:22029824] It has no hemolytic activity against human red blood cells|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 44).|||[Ref:22029824] It has no hemolytic activity against human red blood cells" "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||Zoolog Sci. 2012 Sep;29(9):553-558.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 51.|||Ref.22029824|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 19.PubMed." 17 FPDB02686 AP01861|||DRAMP01499|||AP01861|||DRAMP01499 GIFSKISGKAIKNLFIKGAKNVGKEVGMDVVRTGIDVVGCKIKGEC Anti-Gram- bacteria E. coli, activity value is MIC = 8.8 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 17.6 ug/ml||Anti-S. aureus, activity value is MIC = 4.4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 8.8 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.4 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 17.6 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 45)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 52.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.8 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.4 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.6 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=8.8 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 20.PubMed." 46 FPDB02687 AP01862|||DRAMP01190|||Andersonin-W2|||AP01862|||DRAMP01190 AVNIPFKVHFRCKAAFC Anti-Gram- bacteria E. coli, activity value is MIC = 20.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 40.4 ug/ml||Anti-S. aureus, activity value is MIC = 10.1 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 20.2 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 20.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 40.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10.1 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 20.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||[Ref:22029824] It has no hemolytic activity against human red blood cells|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 46).|||[Ref:22029824] It has no hemolytic activity against human red blood cells" "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 53.|||Ref.22029824|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 21.PubMed." 17 FPDB02688 AP01863|||DRAMP01501|||AP01863|||DRAMP01501 GIFSKISGKAIKNLFIKGAKNVGKRVGMDVVRTGMDVVGCKIKGEC Anti-Gram- bacteria E. coli, activity value is MIC = 5.5 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 11 ug/ml||Anti-S. aureus, activity value is MIC = 11 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 11 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5.5 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 11 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 11 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 47)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 54.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.5 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=11 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 22.PubMed." 46 FPDB02689 AP01864|||DRAMP01502|||AP01864|||DRAMP01502 GIFSKISGKAIKNLFIKGAENVGKHVGIDVVRTGIDVVGCKIKGEC Anti-Gram- bacteria E. coli, activity value is MIC = 8.6 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 8.6 ug/ml||Anti-S. aureus, activity value is MIC = 8.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 8.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 8.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 8.6 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora, China, Asia|||Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 48)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 55.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.6 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.6 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=8.6 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 23.PubMed." 46 FPDB02690 AP01865|||DRAMP01503|||AP01865|||DRAMP01503 GIFSKISGKAIKNLFIKGAKNVGKEVGIDVVRTGMDVVGCKIKGEC Anti-Gram- bacteria E. coli, activity value is MIC = 4.1 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 8.2 ug/ml||Anti-S. aureus, activity value is MIC = 4.1 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 2.1 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 4.1 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 8.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora, China, Asia|||Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 49)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 56.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=4.1 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.1 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.2 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=2.1 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 24.PubMed." 46 FPDB02691 AP01866|||Esculentin-2-OA1|||DRAMP01504|||Esculentin-2-OA1|||AP01866|||DRAMP01504|||AP01866 GIFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC Anti-Gram- bacteria E. coli, activity value is MIC = 8.5 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 4.3 ug/ml||Anti-S. aureus, activity value is MIC = 4.3 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 8.5 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.5 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.3 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 4.3 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 8.5 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii; Odorrana jingdongensis, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii; Odorrana jingdongensis, China, Asia N/A "Odorrana andersonii; Odorrana jingdongensis, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 50)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 57.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.5 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.3 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.3 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=8.5 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 25.PubMed." 37 FPDB02692 AP01867|||Esculentin-2-OA2|||DRAMP01505|||Esculentin-2-OA2|||AP01867|||DRAMP01505|||AP01867 GLFTLIKGAAKLIGKTTAKEAGKTGKLEMACKITNQC Anti-Gram- bacteria E. coli, activity value is MIC = 4.4 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 2.2 ug/ml||Anti-S. aureus, activity value is MIC = 2.2 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 4.4 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 10.8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 21.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 21.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 4.4 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 4.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 2.2 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Chinese odorous frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 51)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 58.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.8 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21.6 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 26.PubMed." 37 FPDB02693 AP01868|||Odorranain-F-OW1|||DRAMP01401|||Odorranain-F-OW1|||AP01868|||DRAMP01401|||AP01868 GFMNTAKNVAKNVAVTLLDNLKCKITGGC Anti-Gram- bacteria E. coli, activity value is MIC = 8 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 17.8 ug/ml||Anti-S. aureus, activity value is MIC = 17.8 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 8.9 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.9 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 8.9 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 17.8 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 17.8 ug/ml||Anti-Escherichia coli, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 4 uM||Anti-Staphylococcus aureus, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana wuchuanensis|||Odorrana wuchuanensis (Chinese odorous frog)|||Odorrana wuchuanensis|||Odorrana wuchuanensis, China, Asia|||Odorrana wuchuanensis (Chinese odorous frog)|||Odorrana wuchuanensis, China, Asia N/A "Odorrana wuchuanensis, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 52)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 59.|||Gram-negative bacteria: Escherichia coli (MIC=2 uM), Pseudomonas aeruginosa (MIC=4 uM); Gram-positive bacterium: Staphylococcus aureus (MIC=4 uM). Yeast: Candida albicans ATCC 2002 (MIC=2 uM).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 27.PubMed." 29 FPDB02694 AP01869|||Odorranain-J-OA2|||DRAMP01403|||Odorranain-J-OA2|||AP01869|||DRAMP01403|||AP01869 GLFTLIKGAYKNDAPTVACN Anti-B. pyocyaneus, activity value is MIC = 48.6 ug/ml||Anti-E. coli, activity value is MIC = 24.3 ug/ml||Anti-S. aureus, activity value is MIC = 12.2 ug/ml||Anti-and C. albicans, activity value is MIC = 24.3 uM||Antibacterial||Antifungal ; Odorrana andersonii [Golden crossband frog]||Anti-Escherichia coli ATCC 25922, activity value is MIC = 24.3 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 24.3 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 48.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 40.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 40.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 20.1 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 20.1 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii [Golden crossband frog]|||Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii, China, Asia|||Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||Escherichia coli ATCC 25922 ( MIC = 24.3 ug/ml ), Candida albicans ATCC 2002 ( MIC = 24.3 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 12.2 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 48.6 ug/ml )|||[Ref:22029824]Not found|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 53)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||https://pubmed.ncbi.nlm.nih.gov/22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 60.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=20.1 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 28.PubMed." 20 FPDB02695 AP01870|||Esculentin-2-OR2|||DRAMP01508|||Esculentin-2-OR2|||AP01870|||DRAMP01508|||AP01870 GVFTLIKGATQLIGKTLGKEVGKTGLELMACKITKQC Anti-Gram- bacteria E. coli, activity value is MIC = 8.1 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 16.2 ug/ml||Anti-S. aureus, activity value is MIC = 4.1 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 8.1 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.1 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 16.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 8.1 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora|||Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 54)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 61.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.1 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.1 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=16.2 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=8.1 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 29.PubMed." 37 FPDB02696 AP01871|||Esculentin-2-OR3|||DRAMP01509|||Esculentin-2-OR3|||AP01871|||DRAMP01509|||AP01871 GVFTLLKGATQLIGKTLGKELGKTGLELMACKITNQC Anti-Gram- bacteria E. coli, activity value is MIC = 7.9 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 7.9 ug/ml||Anti-S. aureus, activity value is MIC = 7.9 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 15.8 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 7.9 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 7.9 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 7.9 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 15.8 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora|||Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 55)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 62.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=7.9 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=7.9 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.9 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=15.8 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 30.PubMed." 37 FPDB02697 AP01872|||Esculentin-2-OR4|||DRAMP01510|||Esculentin-2-OR4|||AP01872|||DRAMP01510|||AP01872 GVFTLIKGATQLIGKTLGKELGKTGLELMACKITEQC Anti-B. pyocyaneus, activity value is MIC = 3.6 ug/ml||Anti-E. coli, activity value is MIC = 3.6 ug/ml||Anti-S. aureus, activity value is MIC = 3.6 ug/ml||Anti-and C. albicans, activity value is MIC = 3.6 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 3.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 3.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3.6 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora|||Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 56)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 63.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.6 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3.6 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=3.6 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=3.6 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 31.PubMed." 37 FPDB02698 AP01873|||Esculentin-2-OR5|||DRAMP01511|||Esculentin-2-OR5|||AP01873|||DRAMP01511|||AP01873 GVFTLIKGATQLIGKTLGKELGKTGLEIMACKITKQC Anti-Gram- bacteria E. coli, activity value is MIC = 15.8 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 15.8 ug/ml||Anti-S. aureus, activity value is MIC = 15.8 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 7.9 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 15.8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 15.8 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 15.8 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 7.9 ug/ml||Anti-Gram+ & Gram-||candidacidal Odorrana rotodora|||Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora|||Odorrana rotodora, China, Asia|||Odorrana rotodora (Chinese odorous frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 57)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 64.|||Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=15.8 ug/ml); Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15.8 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=15.8 ug/ml). Yeast: Candida albicans ATCC 2002 (MIC=7.9 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 32.PubMed." 37 FPDB02699 AP01874|||Andersonin-X1|||DRAMP01191|||Andersonin-X1|||AP01874|||DRAMP01191|||AP01874 GLFSKFAGKGIVNFLIEGVE Anti-Gram- bacteria E. coli, activity value is MIC = 30.5 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 15.3 ug/ml||Anti-S. aureus, activity value is MIC = 15.3 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 30.5 ug/ml||Antibacterial||Antifungal ; Odorrana andersonii [Golden crossband frog]||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30.5 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 30.5 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 15.3 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 15.3 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Golden crossband frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||Escherichia coli ATCC 25922 ( MIC = 30.5 ug/ml ), Candida albicans ATCC 2002 ( MIC = 30.5 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 15.3 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 15.3 ug/ml )|||[Ref:22029824]Not found|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 58).|||[Ref:22029824]Not found" "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||https://pubmed.ncbi.nlm.nih.gov/22029824|||Zoolog Sci. 2012 Sep;29(9):553-558.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 65.|||Ref.22029824|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 33.PubMed." 20 FPDB02700 AP01875|||Nigrocin-1-OA|||DRAMP01426|||Nigrocin-1-OA1|||AP01875|||DRAMP01426|||AP01875 GLLSGVLGVGKKIVCGLSGLC Anti-Gram- bacteria E. coli, activity value is MIC = 5.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 10.4 ug/ml||Anti-S. aureus, activity value is MIC = 10.4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 5.2 ug/ml||Anti-S.enteritidis, activity value is MIC = 128 ug/ml||Anti-and S. aureus ATCC 29213, activity value is MIC = 16||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 5.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10.4 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 10.4 ug/ml||Anti-Gram-negative bacteria: Escherichia coli ATCC 25922, activity value is MIC = 5.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Asian frog)|||sequence homology|||Odorrana andersonii (Asian frog)|||sequence homology N/A "sequence homology|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 59).|||HC50 >128 ug/ml." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22029824||Ref:22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 66.|||[Ref.22029824]Gram-negative bacteria: Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.2 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10.4 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.4 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=5.2 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 34.PubMed." 21 FPDB02701 AP01876|||Nigrocin-1-OA2|||DRAMP01427|||Nigrocin-1-OA2|||AP01876|||DRAMP01427|||AP01876 GIFGKILGVGKKTLCELSGMC Anti-Gram- bacteria E. coli, activity value is MIC = 6.3 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 6.3 ug/ml||Anti-S. aureus, activity value is MIC = 6.3 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 3.2 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.3 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.3 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 6.3 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii (Asian frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Asian frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 60)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 67.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.3 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=3.2 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 35.PubMed." 21 FPDB02702 AP01877|||Nigrocin-1-OA3|||DRAMP01428|||Nigrocin-1-OA3|||AP01877|||DRAMP01428|||AP01877 GIFLKVLGVGKKVLCGVSGLC Anti-Gram- bacteria E. coli, activity value is MIC = 10.8 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 21.6 ug/ml||Anti-S. aureus, activity value is MIC = 5.4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 10.8 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 10.8 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 10.8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5.4 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 21.6 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana rotodora|||Odorrana andersonii (Asian frog)|||Odorrana andersonii, China, Asia|||Odorrana andersonii (Asian frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 61)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 68.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.8 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.4 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=10.8 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 36.PubMed." 21 FPDB02703 AP01878|||Nigrocin-1-OR1|||DRAMP01429|||DRAMP01430|||DRAMP01431|||DRAMP01432|||Nigrocin-1-OR1|||AP01878|||DRAMP01429|||AP01878 GLISGILGVGKKLVCGLSGLC Anti-Gram- bacteria E. coli, activity value is MIC = 11.5 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 23 ug/ml||Anti-S. aureus, activity value is MIC = 5.8 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 11.5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 11.5 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 11.5 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5.8 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 23 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 17.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 8.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 8.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 10.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 20.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 20.4 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 10.2 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 12.4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3.1 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana rotodora|||Odorrana andersonii (Asian frog)|||Odorrana rotodora, China, Asia|||Odorrana andersonii (Asian frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 62)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 69.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.5 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=23 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.8 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=11.5 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 37.PubMed." 21 FPDB02704 AP01879|||Nigrocin-1-OR2|||DRAMP01430|||Nigrocin-1-OR2|||AP01879|||DRAMP01430|||AP01879 GLISGILGVGKMLVCGLSGLC Anti-Gram- bacteria E. coli, activity value is MIC = 8.6 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 17.2 ug/ml||Anti-S. aureus, activity value is MIC = 8.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 8.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 8.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 8.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 17.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana rotodora|||Odorrana andersonii (Asian frog)|||Odorrana rotodora, China, Asia|||Odorrana andersonii (Asian frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 63)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 70.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.2 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.6 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=8.6 ug/ml)|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 38.PubMed." 21 FPDB02705 AP01880|||Nigrocin-1-OR3|||DRAMP01431|||Nigrocin-1-OR3|||AP01880|||DRAMP01431|||AP01880 GLISGLLGVGKMLVCGLSGLC Anti-Gram- bacteria E. coli, activity value is MIC = 10.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 20.4 ug/ml||Anti-S. aureus, activity value is MIC = 20.4 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 10.2 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 10.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 10.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 20.4 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 20.4 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana rotodora|||Odorrana andersonii (Asian frog)|||Odorrana rotodora, China, Asia|||Odorrana andersonii (Asian frog)|||Odorrana rotodora, China, Asia N/A "Odorrana rotodora, China, Asia|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 64)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 71.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.2 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20.4 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.4 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=10.2 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 39.PubMed." 21 FPDB02706 AP01881|||Odorranain-J-OA1|||DRAMP01402|||Odorranain-J-OA1|||AP01881|||DRAMP01402|||AP01881 GLFTLIKGAYKLDAPTVACN Anti-B. pyocyaneus, activity value is MIC = 40.2 ug/ml||Anti-E. coli, activity value is MIC = 40.2 ug/ml||Anti-S. aureus, activity value is MIC = 20.1 ug/ml||Anti-and C. albicans, activity value is MIC = 20.1 ug/ml||Antibacterial||Antifungal ; Odorrana andersonii [Golden crossband frog]||Anti-Escherichia coli ATCC 25922, activity value is MIC = 40.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 20.1 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 20.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 40.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii [Golden crossband frog]|||Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii, China, Asia|||Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||Escherichia coli ATCC 25922 ( MIC = 40.2 ug/ml ), Candida albicans ATCC 2002 ( MIC = 20.1 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 20.1 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 40.2 ug/ml )|||[Ref:22029824]Not found|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 65)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||https://pubmed.ncbi.nlm.nih.gov/22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 72.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 ug/ml)； Yeast: Candida albicans ATCC 2002 (MIC=20.1 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 40.PubMed." 20 FPDB02707 AP01882|||Nigrocin-1-OW2|||DRAMP01432|||Nigrocin-1-OW2|||AP01882|||DRAMP01432|||AP01882 GILGNIVGMGKKIVCGLSGLC Anti-Gram- bacteria E. coli, activity value is MIC = 6.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 12.4 ug/ml||Anti-S. aureus, activity value is MIC = 6.2 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 3.1 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 12.4 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana wuchuanensis|||Odorrana andersonii (Asian frog)|||Odorrana wuchuanensis, China, Asia|||Odorrana andersonii (Asian frog)|||Odorrana wuchuanensis, China, Asia N/A "Odorrana wuchuanensis, China, Asia|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 66)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 73.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.2 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=3.1 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 41.PubMed." 21 FPDB02708 AP01883|||Nigrocin-1-OW3|||DRAMP01433|||Nigrocin-1-OW3|||AP01883|||DRAMP01433|||AP01883 GILGNIVGMGKKVVCGLSGLC Anti-Gram- bacteria E. coli, activity value is MIC = 11.3 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 22.6 ug/ml||Anti-S. aureus, activity value is MIC = 11.3 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 6.7 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 11.3 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 6.7 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 11.3 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 22.6 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana wuchuanensis|||Odorrana andersonii (Asian frog)|||Odorrana wuchuanensis, China, Asia|||Odorrana andersonii (Asian frog)|||Odorrana wuchuanensis, China, Asia N/A "Odorrana wuchuanensis, China, Asia|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 67)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 74.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.3 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22.6 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.3 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=6.7 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 42.PubMed." 21 FPDB02709 AP01884|||Nigrocin-1-OW4|||DRAMP01434|||Nigrocin-1-OW4|||AP01884|||DRAMP01434|||AP01884 GILSGVLGMGKKIVCGLRGLC Anti-Gram- bacteria E. coli, activity value is MIC = 7.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 14.2 ug/ml||Anti-S. aureus, activity value is MIC = 3.6 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 7.2 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 7.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 7.2 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 14.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana wuchuanensis|||Odorrana andersonii (Asian frog)|||Odorrana wuchuanensis, China, Asia|||Odorrana andersonii (Asian frog)|||Odorrana wuchuanensis, China, Asia N/A "Odorrana wuchuanensis, China, Asia|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 68)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.2 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=14.2 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.6 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=7.2 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 43.PubMed." 21 FPDB02710 AP01885|||Nigrocin-1-OW5|||DRAMP01435|||Nigrocin-1-OW5|||AP01885|||DRAMP01435|||AP01885 GILGNIVGMGKQVVCGLSGLC Anti-Gram- bacteria E. coli, activity value is MIC = 5.1 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 10.2 ug/ml||Anti-S. aureus, activity value is MIC = 5.1 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 5.1 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5.1 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 5.1 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 10.2 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana wuchuanensis|||Odorrana andersonii (Asian frog)|||Odorrana wuchuanensis, China, Asia|||Odorrana andersonii (Asian frog)|||Odorrana wuchuanensis, China, Asia N/A "Odorrana wuchuanensis, China, Asia|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 69)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 76.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.1 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10.2 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.1 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=5.1 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 44.PubMed." 21 FPDB02711 AP01886|||Odorranain-A-OA1|||DRAMP01395|||Odorranain-A-OA1|||AP01886|||DRAMP01395|||AP01886 VVKCSYRLGSPDSQCN Anti-Gram- bacteria E. coli, activity value is MIC = 35.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 17.6 ug/ml||Anti-S. aureus, activity value is MIC = 35.2 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 17.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 35.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 17.6 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 35.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 17.6 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Odorrana andersonii|||Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ug/ml.|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 70).|||[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ug/ml." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||Peptides. 2007 Aug;28(8):1527-1531||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 77.|||Ref.22029824|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 45.PubMed." 16 FPDB02712 AP01887|||DRAMP01396|||Odorranain-F-OA1|||AP01887|||DRAMP01396 GFMDTAKNVAKNMAGNLLDNLKCKITKAC Anti-Gram- bacteria E. coli, activity value is MIC = 5 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 10 ug/ml||Anti-S. aureus, activity value is MIC = 2.5 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 2.5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2.5 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 2.5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ug/ml.|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 71).|||[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ug/ml." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||Peptides. 2007 Aug;28(8):1527-1531||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 78.|||Ref.22029824|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 46.PubMed." 29 FPDB02713 AP01888|||DRAMP01397|||AP01888|||DRAMP01397 GFMDTAKNVAKNMAVTLLDNLKCKITKAC Anti-Gram- bacteria E. coli, activity value is MIC = 7.5 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 7.5 ug/ml||Anti-S. aureus, activity value is MIC = 3.8 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 3.8 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 7.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 7.5 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.8 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3.8 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii, China, Asia|||Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ug/ml.|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 72).|||[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ug/ml." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||Peptides. 2007 Aug;28(8):1527-1531||Ref.22029824|||22029824||Ref.22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 79.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.5 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.5 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.8 ug/ml); Yeast: Candida albicans ATCC 2002 (MIC=3.8 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 47.PubMed." 29 FPDB02714 AP01889|||Odorranain-F-OA3|||DRAMP01398|||DRAMP01399|||Odorranain-F-OA3|||AP01889|||DRAMP01398|||AP01889 GFMDTAKNVAKNEAGNLLDNLKCKITKAC Anti-Gram- bacteria E. coli, activity value is MIC = 12.6 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 12.6 ug/ml||Anti-S. aureus, activity value is MIC = 6.3 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 6.3 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 12.6 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 6.3 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.3 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 12.6 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.2 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 4.1 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.1 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii [Golden crossband frog]|||Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ug/ml.|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 73).|||[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ug/ml." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319.||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 80.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.6 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.6 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ug/ml)； Yeast: Candida albicans ATCC 2002 (MIC=6.3 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 48.PubMed." 29 FPDB02715 AP01890|||Odorranain-F-OA4|||DRAMP01399|||Odorranain-F-OA4|||AP01890|||DRAMP01399|||AP01890 GFMATAKNVAKNMDVTLLDNLKCKITKAC Anti-Gram- bacteria E. coli, activity value is MIC = 8.2 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 4.1 ug/ml||Anti-S. aureus, activity value is MIC = 4.1 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 4.1 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8.2 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 4.1 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 4.1 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana andersonii [Golden crossband frog]|||Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii [Golden crossband frog]|||Odorrana andersonii, China, Asia|||Odorrana grahami (Yunnanfu frog)|||Odorrana andersonii, China, Asia N/A "Odorrana andersonii, China, Asia|||[Ref:22029824] Not found in the literature|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 74)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 81.|||[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.2 ug/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.1 ug/ml); Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.1 ug/ml)； Yeast: Candida albicans ATCC 2002 (MIC=4.1 ug/ml).|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 49.PubMed." 29 FPDB02716 AP01891|||Hejiangin-A1|||DRAMP01199|||Hejiangin-A1|||AP01891|||DRAMP01199|||AP01891 RFIYMKGFGKPRFGKR Anti-B. pyocyaneus, activity value is MIC = 25 ug/ml||Anti-E. coli, activity value is MIC = 100 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-and C. albicans, activity value is MIC = 50 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 100 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 25 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 25 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Antioxidant||anti-diabetes Odorrana hejiangensis|||Odorrana hejiangensis|||Odorrana hejiangensis [Hejiang odorous frog]|||sequence homology|||sequence homology N/A "sequence homology|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 75)." "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 82.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 50.PubMed." 16 FPDB02717 AP01892|||Hejiangin-F1|||DRAMP01200|||Hejiangin-F1|||AP01892|||DRAMP01200|||AP01892 IPWKLPATFRPVERPFSKPFCRKD Anti-weakly active against Gram- E.coli, activity value is MIC > 100 ug/ml||Anti-B. pyocyaneus, activity value is MIC = 100 ug/ml||Anti-S. aureus, activity value is MIC = 100 ug/ml||Anti-and yeast C. albicans, activity value is MIC = 100 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC > 100 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 100 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 100 ug/ml||Anti-Gram+||candidacidal Odorrana hejiangensis [Hejiang odorous frog]|||Odorrana hejiangensis|||Odorrana hejiangensis [Hejiang odorous frog]|||Odorrana hejiangensis, China, Asia|||Odorrana hejiangensis|||Odorrana hejiangensis, China, Asia N/A "Odorrana hejiangensis, China, Asia|||Escherichia coli ATCC 25922 ( MIC >100 ug/ml ), Candida albicans ATCC 2002 ( MIC = 100 ug/ml ), Staphylococcus aureus ATCC 25923 ( MIC = 100 ug/ml ), Bacillus pyocyaneus CMCCB 10104 ( MIC = 100 ug/ml )|||[Ref:22029824]Non-hemolytic activity against human red blood cells|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 76).|||[Ref:22029824]Non-hemolytic activity against human red blood cells" "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||22029824|||J Proteome Res. 2012 Jan 1;11(1):306-319||Ref.22029824|||22029824||Ref.22029824|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 83.|||Ref.22029824|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 51.PubMed." 24 FPDB02718 AP01893|||DRAMP01201|||Schmackerin-C1|||AP01893|||DRAMP01201 AAPRGGKGFFCKLFKDC Anti-weakly active against B. pyocyaneus, activity value is MIC = 50 ug/ml||Anti-E. coli, activity value is MIC = 100 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-and C. albicans, activity value is MIC = 100 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 100 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 50 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 100 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana hejiangensis|||Odorrana schmackeri|||Odorrana schmackeri, China, Asia|||Odorrana schmackeri|||Odorrana schmackeri, China, Asia N/A "Odorrana schmackeri, China, Asia|||Only Andersonin-C1 showed obvious hemolytic activity against human red blood cells at the concentration of 50 ug/ml. All of the rest synthesized peptides showed no hemolytic activity under the test conditions (Table 77).|||not hemo.lytic" "J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 18.|||J Proteome Res. 2012 Jan 1;11(1):306-319|||22029824|||J Proteome Res . 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. Epub 2011 Nov 84.|||J Proteome Res. 2012 Jan 1;11(1):306-19. Epub 2011 Nov 52.PubMed." 17 FPDB02735 AP01908|||Ranacyclin-B-RL1|||Ranacyclin-B-RL1|||AP01908|||AP01908 AALRGCWTKSIPPKPCPGKR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Antifungal ; Odorrana livida||Anti-Candida albicans ATCC 20032, activity value is MIC = 46.2 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5.8 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 46.2 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 46.2 uM Odorrana livida|||Odorrana livida, Asia N/A Odorrana livida, Asia|||Candida albicans ATCC 20032 ( MIC = 46.2 uM ), Staphylococcus aureus ATCC 25923 ( MIC = 5.8 uM ), Escherichia coli ATCC 25922 ( MIC = 46.2 uM ), Bacillus subtilis ATCC 6633 ( MIC = 46.2 uM ) "Amino Acids. 2012 Jul;43(1):309-16. doi: 10.1007/s00726-011-1079-8. Epub 2011 Sep 17.|||https://pubmed.ncbi.nlm.nih.gov/21927839|||21927839|||Amino Acids . 2012 Jul;43(1):309-16. doi: 10.1007/s00726-011-1079-8. Epub 2011 Sep 17.|||Amino Acids. 2012 Jul;43(1):309-16.PubMed." 20 FPDB02738 AP01911|||Ranacyclin-B-RN6|||DRAMP02281|||Ranacyclin-B-RN6|||AP01911|||AP01911 SALVGCWTKSYPPNPCFGRG Anti-Gram+||Antifungal||candidacidal||Antibacterial||Antifungal ; Rana nigrovittata [Black-striped frog]||Anti-Candida albicans ATCC 20032, activity value is MIC = 46.7 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 11.7 uM||Anti-Staphylococcus aureus, activity value is MIC = 11.7 uM Rana nigrovittata [Black-striped frog]|||Hylarana nigrovittata (Ranidae frogs)|||Hylarana nigrovittata, Asia|||Hylarana nigrovittata, Asia N/A Hylarana nigrovittata, Asia|||Candida albicans ATCC 20032 ( MIC = 46.7 uM ), Staphylococcus aureus ATCC 25923 ( MIC = 11.7 uM )|||In Document 7 (Amino Acids 2012), the specific hemolytic values of ranacyclin B-like bifunctional peptides (with trypsin inhibitory activity and antimicrobial activity) in the skin secretions of five frog species are not explicitly mentioned. "Amino Acids. 2012 Jul;43(1):309-16. doi: 10.1007/s00726-011-1079-8. Epub 2011 Sep 17.|||https://pubmed.ncbi.nlm.nih.gov/21927839|||Amino Acids. 2012 Jul;43(1):309-316.|||21927839|||Amino Acids . 2012 Jul;43(1):309-16. doi: 10.1007/s00726-011-1079-8. Epub 2011 Sep 17.|||Amino Acids. 2012 Jul;43(1):309-16.PubMed." 20 FPDB02750 AP01926|||Prepromelittin-related peptide|||DRAMP01346|||DRAMP01347|||Prepromelittin-related peptide|||AP01926|||DRAMP01346|||AP01926 VIGSILGALASGLPTLISWIKNR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Escherichia coli, activity value is MIC = 25 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Staphylococcus aureus, activity value is MIC = 3.5 uM||Anti-Escherichia coli, activity value is MIC = 20 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 3.13 uM||Anti-Bacillus subtilis, activity value is MIC = 3.13 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 12.5 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 12.5 uM||Anti-E. coli, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 6 uM||Anti-C. albicans, activity value is MIC = 25 uM Rana sakuraii [Japanese brown frog]|||Rana sakuraii (Japanese brown frog)|||skin, the stream brown frog, Rana sakuraii, Japan, Asia|||Rana sakuraii (Japanese brown frog)|||skin, the stream brown frog, Rana sakuraii, Japan, Asia N/A skin, the stream brown frog, Rana sakuraii, Japan, Asia|||E. coli ( MIC = 25 uM ), S. aureus ( MIC = 6 uM ), C. albicans ( MIC = 25 uM ) "Peptides. 2007 Mar;28(3):505-14. doi: 10.1016/j.peptides.2006.10.016. Epub 2006 Dec 14.|||17174009|||Peptides. 2007;28(3):505-514.|||Peptides. 2007;28(3):505-514.||Ref.12804591||Ref.27271216|||17174009|||Peptides . 2007 Mar;28(3):505-14. doi: 10.1016/j.peptides.2006.10.016. Epub 2006 Dec 14.|||Peptides. 2007 Mar;28(3):505-14. PubMed." 23 FPDB02764 AP01942|||Nigroain-E1|||DRAMP01543|||Nigroain-E1|||AP01942|||DRAMP01543|||AP01942 DCTRWIIGINGRICRD Anti-S. aureus ATCC25923, activity value is MIC = 18.75 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 18.75 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 75 ug/ml||Antibacterial||Antifungal||Anti-Gram+||candidacidal Rana nigrovittata|||Rana nigrovittata (Black-striped frog)|||Rana nigrovittata [Black-striped frog]|||skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata (Black-striped frog)|||skin secretions, Rana nigrovittata , China, Asia N/A "skin secretions, Rana nigrovittata , China, Asia|||[Ref:19778602]7.62±1.6% hemolytic activity at 100 ug/ml against rabbit red cells|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K2 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity.|||[Ref:19778602]7.62±1.6% hemolytic activity at 100 ug/ml against rabbit red cells" "Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||19778602|||19778602||Ref.19778602|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22|||[Ref.19778602]Gram-positive bacterium: Staphylococcus aureus ATCC25923 (MIC=18.75 ug/ml); Yeast: Candida albicans ATCC2002 (MIC=75 ug/ml).|||Genomics. 2010 Jan;95(1):66-71. PubMed." 16 FPDB02765 AP01943|||DRAMP01546|||AP01943|||DRAMP01546 SLWETIKNAGKGFIQNLDKIR Anti-S. aureus ATCC25923, activity value is MIC = 9.38 ug/ml||Anti-B. subtilis, activity value is MIC = 21.88 ug/ml||Anti-and E. coli ML-35P, activity value is MIC = 37.5 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 9.38 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 21.88 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 32.74 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Rana nigrovittata (Black-striped frog)|||skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata (Black-striped frog)|||skin secretions, Rana nigrovittata , China, Asia N/A "skin secretions, Rana nigrovittata , China, Asia||0.2249|||In the study of black-banded frog skin antimicrobial peptides, rabbit red blood cells were used as the test subject. Most antimicrobial peptides exhibited weak hemolysis at a concentration of 100 µg/ml, while Nigroain-K2 and Temporin-RN1 showed a hemolysis rate of 85%–95% at a concentration of 50 µg/ml. Temporin-RN3 had a hemolysis rate of 87.2% at 100 µg/ml. Nigroain-K1, due to the lack of a C-terminal disulfide bond, showed significantly reduced hemolytic activity, with a hemolysis rate of only 22.49±4.80% at 100 µg/ml.|||[Ref:19778602]22.49 ± 4.8% hemolytic activity at 100 ug/ml against rabbit red cells|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K3 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity.|||[Ref:19778602]22.49 ± 4.8% hemolytic activity at 100 ug/ml against rabbit red cells" "Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||Genomics. 2010 Jan;95(1):66-71.||Ref.19778602|||19778602||Ref.19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=9.38 ug/ml), Bacillus subtilis (MIC=21.88 ug/ml); Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.5 ug/ml); Yeast: Candida albicans ATCC2002 (MIC=32.74 ug/ml).|||Genomics. 2010 Jan;95(1):66-71. PubMed." 21 FPDB02766 AP01948|||Rugosin-RN1|||DRAMP01524|||DRAMP01525|||DRAMP01526|||Rugosin-RN1|||AP01948|||DRAMP01524|||AP01948 SIRDKIKTIAIDLAKSAGTGVLKTLICKLDKSC Anti-S. aureus ATCC25923, activity value is MIC = 4.69 ug/ml||Anti-B. subtilis, activity value is MIC = 9.38 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 25 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 4.69 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 9.38 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 25 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 5.63 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 16.51 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 18.75 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 15 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 12.5 ug/ml||Anti-Gram+ & Gram-||candidacidal||Hemolytic Rana nigrovittata [Black-striped frog]|||Rana nigrovittata|||Rana nigrovittata [Black-striped frog]|||skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata|||skin secretions, Rana nigrovittata , China, Asia N/A "skin secretions, Rana nigrovittata , China, Asia||0.0669|||In the study of black-banded frog skin antimicrobial peptides, rabbit red blood cells were used as the test subject. Most antimicrobial peptides exhibited weak hemolysis at a concentration of 100 µg/ml, while Nigroain-K2 and Temporin-RN1 showed a hemolysis rate of 85%–95% at a concentration of 50 µg/ml. Temporin-RN3 had a hemolysis rate of 87.2% at 100 µg/ml. Nigroain-K1, due to the lack of a C-terminal disulfide bond, showed significantly reduced hemolytic activity, with a hemolysis rate of only 22.49±4.80% at 100 µg/ml.|||[Ref:19778602]Show weak hemolytic activity against rabbit red cells|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K8 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity.|||[Ref:19778602]Show weak hemolytic activity against rabbit red cells" "Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||19778602|||Genomics. 2010 Jan;95(1):66-71.||Ref.19778602|||Genomics. 2010 Jan;95(1):66-71.|||19778602||Ref.19778602|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 27.|||[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.69 ug/ml), Bacillus subtilis (MIC=9.38 ug/ml); Gram-negative bacterium: Escherichia coli ML-35P (MIC=25 ug/ml); Yeast: Candida albicans ATCC2002 (MIC=5.63 ug/ml)|||Genomics. 2010 Jan;95(1):66-71. PubMed." 33 FPDB02767 AP01949|||Rugosin-RN3|||DRAMP01525|||Rugosin-RN3|||AP01949|||DRAMP01525|||AP01949 SIRDKIKTIAIDLAKSAGMGILKTLICKLDKSC Anti-S. aureus ATCC25923, activity value is MIC = 16.5 ug/ml||Anti-B. subtilis, activity value is MIC = 18.75 ug/ml||Anti-E. coli ML-35P, activity value is MIC = 25 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 16.51 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 18.75 ug/ml||Anti-Escherichia coli ML-35P, activity value is MIC = 25 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 15 ug/ml||Anti-Gram+ & Gram-||candidacidal Rana nigrovittata [Black-striped frog]|||Rana nigrovittata|||Rana nigrovittata [Black-striped frog]|||skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata|||skin secretions, Rana nigrovittata , China, Asia N/A "skin secretions, Rana nigrovittata , China, Asia|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K9 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity." "Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||19778602|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 28.|||Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=16.51 ug/ml), Bacillus subtilis (MIC=18.75 ug/ml); Gram-negative bacterium: Escherichia coli ML-35P (MIC=25 ug/ml). Yeast: Candida albicans ATCC2002 (MIC=15 ug/ml).|||Genomics. 2010 Jan;95(1):66-71. PubMed." 33 FPDB02768 AP01951|||DRAMP01807|||Temporin-RN1|||AP01951|||DRAMP01807 FLPLVLGALSGILPKIL Anti-S. aureus, activity value is MIC = 4.69 um||Anti-B. subtilis, activity value is MIC = 9.38 ug/ml||Anti-P. aeruginosa PAO1, activity value is MIC = 4.7 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 8.26 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4.69 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 4.7 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 4.69 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 9.38 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 8.26 ug/ml||Anti-Pseudomonas aeruginosa PA01, activity value is MIC = 4.69 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 4.69 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic Rana nigrovittata|||skin secretions, Rana nigrovittata , China, Asia|||Rana nigrovittata|||skin secretions, Rana nigrovittata , China, Asia N/A "skin secretions, Rana nigrovittata , China, Asia||95.7%(50 ug/ml )|||Some AMPs were found to exert hemolytic activities [6,7]. Rabbit red blood cells were used to check for hemolytic capability in our experiments. Most AMPs exhibited weak hemolytic activity at the concentration of 100 ug/ml (Table 3). In contrast, nigroain-K2, gaegurin-RN1, temporin-RN1, and temporin-RN3 had strong hemo- lytic activity against rabbit red cells. Nigroain-K2 and temporin-RN1 could destroy 85–95% red cells even at the concentration of 50 ug/ml. Compared with nigroain-K2, nigroain-K11 lost the C-terminal disulfide bridge, and had a much weaker hemolytic activity. The current result implies that the C-terminal disulfide bridge may contribute to the hemolytic activity." "Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 22.|||Genomics. 2010 Jan;95(1):66-71.|||19778602|||Genomics . 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. Epub 2009 Sep 30.|||Genomics. 2010 Jan;95(1):66-71. PubMed." 17 FPDB02769 AP01953|||Hainanenin 1|||Hainanenin 1|||AP01953|||DRAMP04621|||AP01953 FALGAVTKLLPSLLCMITRKC Anti-Wide-spectrum activity. Active against Gram+ S. aureus ATCC 2592, activity value is MIC = 18.8 ug/ml||Anti-S. aureus 090223 IS, activity value is MIC = 4.7 ug/ml||Anti-S. aureus 1349+ IS, activity value is MIC = 37.5 ug/ml||Anti-E. faecium 1299 IS, activity value is MIC = 4.7 ug/ml||Anti-N. asteroides 090312 IS, activity value is MIC = 18.8 ug/ml||Anti-A. sobria 090223 IS, activity value is MIC = 18.8 ug/ml||Anti-X. maltophilia 090223 IS, activity value is MIC = 9.4 ug/ml||Anti-P. mirabilis 090223 IS, activity value is MIC = 18.8 ug/ml||Anti-A. baumannii 2373 IS, activity value is MIC = 18.8 ug/ml||Anti-E. coli ATCC 25922, activity value is MIC = 75 ug/ml||Anti-E. coli 1342 IS, activity value is MIC = 9.4 ug/ml||Anti-S. mould 090223 IS, activity value is MIC = 75 ug/ml||Anti-S. mould 090413 IS, activity value is MIC = 4.7 ug/ml||Anti-C. glabrata 0902 IS, activity value is MIC = 75 ug/ml||Anti-and C. albicans ATCC 2002, activity value is MIC = 2.3 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 18.8 ug/ml||Anti-Staphylococcus aureus 090223, activity value is MIC = 4.7 ug/ml||Anti-Staphylococcus aureus 1349+, activity value is MIC = 37.5 ug/ml||Anti-Enterococcus faecium 1299, activity value is MIC = 4.7 ug/ml||Anti-Nocardia asteroides 090312, activity value is MIC = 18.8 ug/ml||Anti-Aeromonas sobria 090223, activity value is MIC = 18.8 ug/ml||Anti-Xanthomonas maltophilia 090223, activity value is MIC = 9.4 ug/ml||Anti-Proteus mirabilis 090223, activity value is MIC = 18.8 ug/ml||Anti-Acinetobacter baumannii 2178, activity value is MIC = 18.8 ug/ml||Anti-Acinetobacter baumannii 2373, activity value is MIC = 18.8 ug/ml||Anti-Klebsiella pneumoniae 1373, activity value is MIC = 75 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 75 ug/ml||Anti-Escherichia coli 1342, activity value is MIC = 9.4 ug/ml||Anti-Slime mould 090223, activity value is MIC = 75 ug/ml||Anti-Slime mould 090413, activity value is MIC = 4.7 ug/ml||Anti-Candida glabrata 0902, activity value is MIC = 75 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 2.3 ug/ml||No MICs found in DRAMP database||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic Amolops hainanensis [Hainan sucker frog]|||skin secretions, Hainan cascade-frog, Amolops hainanensis; China, Asia|||Amolops hainanensis N/A "skin secretions, Hainan cascade-frog, Amolops hainanensis; China, Asia||42.34%(50 ug/ml )|||The hemolytic activity of hainanenin-1 and 5 was then tested. But undesirably, the result showed that hainanenin-1 and 5 possessed strong hemolytic activity on human erythrocytes. At con- centrations of 25 ␮g/ml and 50 ␮g/ml (5–10 times of MICs), the hemolytic rate of hainanenin-1 was 20.72% and 42.34%, respec- tively. At the same concentrations, hainanenin-5 exhibited higher hemolytic rate of 23.31% and 49.14%, respectively.|||No hemolysis information or data found in the reference(s) presented in this entry" "Peptides. 2012 Feb;33(2):251-7. doi: 10.1016/j.peptides.2012.01.014. Epub 2012 Jan 24.|||22306820|||22306820|||Peptides . 2012 Feb;33(2):251-7. doi: 10.1016/j.peptides.2012.01.014. Epub 2012 Jan 24.|||Peptides. 2012 Feb;33(2):251-257.|||Peptides. 2012 Feb;33(2):251-7.. PubMed." 21 FPDB02770 AP01954|||Hainanenin 5|||Hainanenin 5|||AP01954|||DRAMP04622|||AP01954 FALGAVTKRLPSLFCLITRKC Anti-Wide-spectrum activity. Active against Gram+ S. aureus ATCC 2592, activity value is MIC = 18.8 ug/ml||Anti-S. aureus 090223, activity value is MIC = 2.3 ug/ml||Anti-S. aureus 1349+, activity value is MIC = 18.8 ug/ml||Anti-E. faecium 1299, activity value is MIC = 4.7 ug/ml||Anti-N. asteroides 090312, activity value is MIC = 18.8 ug/ml||Anti-A. sobria 090223, activity value is MIC = 9.4 ug/ml||Anti-X. maltophilia 090223, activity value is MIC = 4.7 ug/ml||Anti-P. mirabilis 090223, activity value is MIC = 9.4 ug/ml||Anti-A. baumannii 2178 or 2373, activity value is MIC = 9.4||Anti-K.pneumoniae 1373, activity value is MIC > 100 ug/ml||Anti-E. coli ATCC 25922 or 1342, activity value is MIC = 4.7||Anti-S. mould 090223, activity value is MIC = 75 ug/ml||Anti-S. mould 090413, activity value is MIC = 9.4 ug/ml||Anti-C. glabrata 0902, activity value is MIC = 37.5 ug/ml||Anti-and C. albicans ATCC 2002, activity value is MIC = 2.3 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 18.8 ug/ml||Anti-Staphylococcus aureus 090223, activity value is MIC = 2.3 ug/ml||Anti-Staphylococcus aureus 1349+, activity value is MIC = 18.8 ug/ml||Anti-Enterococcus faecium 1299, activity value is MIC = 4.7 ug/ml||Anti-Nocardia asteroides 090312, activity value is MIC = 18.8 ug/ml||Anti-Aeromonas sobria 090223, activity value is MIC = 9.4 ug/ml||Anti-Xanthomonas maltophilia 090223, activity value is MIC = 4.7 ug/ml||Anti-Proteus mirabilis 090223, activity value is MIC = 9.4 ug/ml||Anti-Acinetobacter baumannii 2178, activity value is MIC = 18.8 ug/ml||Anti-Acinetobacter baumannii 2373, activity value is MIC = 9.4 ug/ml||Anti-Klebsiella pneumoniae 1373, activity value is MIC > 100 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 18.8 ug/ml||Anti-Escherichia coli 1342, activity value is MIC = 4.7 ug/ml||Anti-Slime mould 090223, activity value is MIC = 75 ug/ml||Anti-Slime mould 090413, activity value is MIC = 9.4 ug/ml||Anti-Candida glabrata 0902, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 2.3 ug/ml||No MICs found in DRAMP database||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic Amolops hainanensis [Hainan sucker frog]|||skin secretions, Hainan cascade-frog, Amolops hainanensis; China, Asia|||Amolops hainanensis N/A "skin secretions, Hainan cascade-frog, Amolops hainanensis; China, Asia||49.14%(50 ug/ml )|||The hemolytic activity of hainanenin-1 and 5 was then tested. But undesirably, the result showed that hainanenin-1 and 5 possessed strong hemolytic activity on human erythrocytes. At con- centrations of 25 ␮g/ml and 50 ␮g/ml (5–10 times of MICs), the hemolytic rate of hainanenin-1 was 20.72% and 42.34%, respec- tively. At the same concentrations, hainanenin-5 exhibited higher hemolytic rate of 23.31% and 49.15%, respectively.|||No hemolysis information or data found in the reference(s) presented in this entry" "Peptides. 2012 Feb;33(2):251-7. doi: 10.1016/j.peptides.2012.01.014. Epub 2012 Jan 24.|||22306820|||22306820|||Peptides . 2012 Feb;33(2):251-7. doi: 10.1016/j.peptides.2012.01.014. Epub 2012 Jan 24.|||Peptides. 2012 Feb;33(2):251-257.|||Peptides. 2012 Feb;33(2):251-7.. PubMed." 21 FPDB02772 AP01958|||Lasiocepsin|||Lasiocepsin-NH2|||Las|||DRAMP02992|||Lasiocepsin|||Lasiocepsin-NH2|||Las|||AP01958|||DRAMP02992|||AP01958 GLPRKILCAIAKKKGKCKGPLKLVCKC Anti-B. subtilis, activity value is MIC = 0.4 uM||Anti-E. coli, activity value is MIC = 8.6 uM||Anti-P. aeruginosa, activity value is MIC = 15 uM||Anti-and C. albicans, activity value is MIC = 3.6 uM||Antibacterial||Antifungal||Anti-Bacillus subtilis, activity value is MIC = 0.3 uM||Anti-Staphylococcus aureus, activity value is MIC = 63 uM||Anti-Escherichia coli, activity value is MIC = 3 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 16 uM||Anti-Candida albicans, activity value is MIC = 8 uM||Anti-Bacillus subtilis, activity value is MIC = 0.6 uM||Anti-Staphylococcus aureus, activity value is MIC > 100 uM||Anti-Escherichia coli, activity value is MIC = 42 uM||Anti-Pseudomonas aeruginosa, activity value is MIC > 100 uM||Anti-Candida albicans, activity value is MIC = 25 uM||Anti-Bacillus subtilis, activity value is MIC = 4 uM||Anti-Escherichia coli, activity value is MIC > 100 uM||Anti-Candida albicans, activity value is MIC > 100 uM||Antimicrobial||Antiviral||Anti-Gram+ & Gram-||candidacidal Lasioglossum laticeps|||Lasioglossum laticeps (Eusocial Bee)|||Lasioglossum laticeps|||venom, eusocial bee Lasioglossum laticeps, Europe|||Lasioglossum laticeps (Eusocial Bee)|||venom, eusocial bee Lasioglossum laticeps, Europe Helix venom, eusocial bee Lasioglossum laticeps|||Hemolytic activity( LC50 >200 uM, Human RBC)|||Hemolytic activity( LC50 >200 uM, Human RBC)|||No hemolysis information or data found in the reference(s) presented in this entry "Amino Acids. 2012 Aug;43(2):751-61. doi: 10.1007/s00726-011-1125-6. Epub 2011 Oct 29.|||22038181|||Amino Acids. 2012 Aug;43(2):751-761.|||22038181|||Amino Acids . 2012 Aug;43(2):751-61. doi: 10.1007/s00726-011-1125-6. Epub 2011 Oct 29.|||Amino Acids. 2012 Aug;43(2):751-761.|||Amino Acids. 2012 Aug;43(2):751-61. PubMed." 27 FPDB02773 AP01959|||CAMPSQ3660|||DRAMP01787|||Temporin-HN1|||AP01959|||DRAMP01787|||AP01959 AILTTLANWARKFL Anti-S. aureus ATCC2592, activity value is MIC = 37.5 uM||Anti-S. carnosus KHS, activity value is MIC = 37.5 uM||Anti-B. licheniformis X39, activity value is MIC = 19||Anti-R. rhodochrous X15, activity value is MIC = 4.8 uM||Anti-negative P. faecalis X29, activity value is MIC = 75 uM||Anti-and fungi S. mould 090223 and C. albicans ATCC2002, activity value is MIC = 19||Anti-Enterococcus faecalis 981, activity value is MIC = 150 uM||Anti-S.aureus ATCC 25923, activity value is MIC = 37.5 uM||Anti-S.carnosus KHS, activity value is MIC = 37.5 uM||Anti-B.licheniformis X3, activity value is MIC = 19 uM||Anti-R.rhodochrous X15, activity value is MIC = 4.8 uM||Anti-P.faecalis X29, activity value is MIC = 75 uM||Anti-Slime mould 090223, activity value is MIC = 19 uM||Anti-C. albicans ATCC2002, activity value is MIC = 75 uM||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 37.5 uM||Anti-Staphylococcus carnosus KHS, activity value is MIC = 37.5 uM||Anti-Bacillus licheniformis X39, activity value is MIC = 19 uM||Anti-Rhodococcus rhodochrous X15, activity value is MIC = 4.8 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 75 uM||Anti-Candida albicans ATCC2002, activity value is MIC = 75 uM||Anti-Target Organism Gram-positive bacteria: Staphylococcus aureus ATCC2592, activity value is MIC = 37.5 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Odorrana hainanensis [Odor frog]|||Odorrana hainanensis (Hainan odorous frog)|||Odorrana hainanensis [Odor frog]|||skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia).|||Odorrana hainanensis (Hainan odorous frog)|||skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia). N/A "skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia).|||Hemolytic activity against human erythrocytes (LC50=75 uM)|||In Document 7 (Peptides 2012), the LC₅₀ of Temporin-HN1 for human erythrocytes is 75 µM, the LC₅₀ of Temporin-HN2 for human erythrocytes is 300 µM, the LC₅₀ of Brevinin-1HN1 for human erythrocytes is 75 µM, the LC₅₀ of Brevinin-1V for human erythrocytes is 75 µM, and the LC₅₀ of Brevinin-2HS2 for human erythrocytes is 300 µM.|||[Ref:22450466]IC50=75 uM against washed human erythrocytes|||Hemolytic activity against human erythrocytes (LC50=75 uM)|||Human erythrocytes were used to examine the hemolytic activi- ties, and the results were shown in Table 1. It is observed that all the antimicrobial peptides display a relatively low hemolytic activity against human erythrocytes in vitro. Especially the brevinin-2HS2 and temporin-HN2 show extremely low hemolytic activity.|||[Ref:22450466]IC50=75 uM against washed human erythrocytes" "Peptides. 2012 Jun;35(2):285-90. doi: 10.1016/j.peptides.2012.03.007. Epub 2012 Mar 16.|||22450466|||Peptides. 2012 Jun;35(2):285-290.||Ref.22450466|||22450466||Ref.22450466|||22450466|||Peptides . 2012 Jun;35(2):285-90. doi: 10.1016/j.peptides.2012.03.007. Epub 2012 Mar 16.|||Ref.22450466|||Peptides. 2012 Jun;35(2):285-90. PubMed." 14 FPDB02774 AP01960|||CAMPSQ3661|||DRAMP01788|||Temporin-HN2|||AP01960|||DRAMP01788|||AP01960 NILNTIINLAKKIL Anti-S. aureus ATCC2592, activity value is MIC = 4.8 uM||Anti-S. carnosus KHS, activity value is MIC = 19 uM||Anti-B. licheniformis X39, activity value is MIC = 19 um||Anti-R. rhodochrous X15, activity value is MIC = 2.4 uM||Anti-negative P. faecalis X29, activity value is MIC = 37.5 uM||Anti-and fungi S. mould 090223 and C. albicans ATCC2002, activity value is MIC = 9.5 uM||Anti-S.aureus ATCC 25923, activity value is MIC = 4.8 uM||Anti-S.carnosus KHS, activity value is MIC = 19 uM||Anti-B.licheniformis X3, activity value is MIC = 19 uM||Anti-R.rhodochrous X15, activity value is MIC = 2.4 uM||Anti-P.faecalis X29, activity value is MIC = 37.5 uM||Anti-Slime mould 090223, activity value is MIC = 9.5 uM||Anti-C. albicans ATCC2002, activity value is MIC = 9.5 uM||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 4.8 uM||Anti-Staphylococcus carnosus KHS, activity value is MIC = 19 uM||Anti-Bacillus licheniformis X39, activity value is MIC = 19 uM||Anti-Rhodococcus rhodochrous X15, activity value is MIC = 2.4 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 37.5 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Odorrana hainanensis [Odor frog]|||Odorrana hainanensis (Hainan odorous frog)|||Odorrana hainanensis [Odor frog]|||skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia)|||Odorrana hainanensis (Hainan odorous frog)|||skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia). N/A "skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia)|||Hemolytic activity against human erythrocytes (LC50=300 uM)|||In Document 7 (Peptides 2012), the LC₅₀ of Temporin-HN1 for human erythrocytes is 75 µM, the LC₅₀ of Temporin-HN2 for human erythrocytes is 300 µM, the LC₅₀ of Brevinin-1HN1 for human erythrocytes is 75 µM, the LC₅₀ of Brevinin-1V for human erythrocytes is 75 µM, and the LC₅₀ of Brevinin-2HS2 for human erythrocytes is 300 µM.|||Hemolytic activity against human erythrocytes (LC50=300 uM)|||Human erythrocytes were used to examine the hemolytic activi- ties, and the results were shown in Table 1. It is observed that all the antimicrobial peptides display a relatively low hemolytic activity against human erythrocytes in vitro. Especially the brevinin-2HS2 and temporin-HN3 show extremely low hemolytic activity." "Peptides. 2012 Jun;35(2):285-90. doi: 10.1016/j.peptides.2012.03.007. Epub 2012 Mar 16.|||22450466|||Peptides. 2012 Jun;35(2):285-290.|||22450466|||Peptides . 2012 Jun;35(2):285-90. doi: 10.1016/j.peptides.2012.03.007. Epub 2012 Mar 16.|||Peptides. 2012 Jun;35(2):285-90. PubMed." 14 FPDB02775 AP01961|||Brevinin-1HN1|||DRAMP02001|||AP01961|||AP01961 FLPLIASLAANFVPKIFCKITKKC Anti-E. faecium, activity value is MIC = 19 uM||Anti-S. aureus ATCC2592, activity value is MIC = 1.2 uM||Anti-S. carnosus KHS, activity value is MIC = 4.8 uM||Anti-B. licheniformis X39, activity value is MIC = 2.4 um||Anti-R. rhodochrous X15, activity value is MIC = 1.2 uM||Anti-negative P. faecalis X29, activity value is MIC = 4.8 uM||Anti-and fungi S. mould 090223 and C. albicans ATCC2002, activity value is MIC = 1.2||Antibacterial||Anti-Enterococcus faecium 091299, activity value is MIC = 19 uM||Anti-Enterococcus faecalis 981, activity value is MIC = 19 uM||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 1.2 uM||Anti-Staphylococcus carnosus KHS, activity value is MIC = 4.8 uM||Anti-Bacillus licheniformis X39, activity value is MIC = 2.4 uM||Anti-Rhodococcus rhodochrous X15, activity value is MIC = 1.2 uM||Anti-Escherichia coli ATCC25922, activity value is MIC = 150 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 4.8 uM||Anti-Slime mould 090223, activity value is MIC = 1.2 uM||Anti-Candida albicans ATCC2002, activity value is MIC = 2.4 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana hainanensis [Odor frog]|||Odorrana hainanensis (Hainan odorous frog)|||skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia)|||skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia) N/A "skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia)|||Hemolytic activity against human erythrocytes (LC50=75 uM)|||In Document 7 (Peptides 2012), the LC₅₀ of Temporin-HN1 for human erythrocytes is 75 µM, the LC₅₀ of Temporin-HN2 for human erythrocytes is 300 µM, the LC₅₀ of Brevinin-1HN1 for human erythrocytes is 75 µM, the LC₅₀ of Brevinin-1V for human erythrocytes is 75 µM, and the LC₅₀ of Brevinin-2HS2 for human erythrocytes is 300 µM.|||[Ref.22450466] LC50=75 uM against human erythrocytes|||Human erythrocytes were used to examine the hemolytic activi- ties, and the results were shown in Table 1. It is observed that all the antimicrobial peptides display a relatively low hemolytic activity against human erythrocytes in vitro. Especially the brevinin-2HS2 and temporin-HN4 show extremely low hemolytic activity." "Peptides. 2012 Jun;35(2):285-90. doi: 10.1016/j.peptides.2012.03.007. Epub 2012 Mar 16.|||22450466|||Peptides. 2012 Jun;35(2):285-290.||Ref.22450466|||22450466||Ref.22450466|||Peptides . 2012 Jun;35(2):285-90. doi: 10.1016/j.peptides.2012.03.007. Epub 2012 Mar 16.|||Peptides. 2012 Jun;35(2):285-90. PubMed." 24 FPDB02776 AP01962|||DRAMP02004|||AP01962 FLPLIASVAANLVPKIFCKITKKC Anti-S. aureus ATCC2592, activity value is MIC = 19 uM||Anti-B. licheniformis X39, activity value is MIC = 37.5 uM||Anti-R. rhodochrous X15, activity value is MIC = 9.5 uM||Anti-negative P. faecalis X29, activity value is MIC = 9.5 uM||Anti-and fungi S. mould 090223 and C. albicans ATCC2002, activity value is MIC = 19||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 19 uM||Anti-Bacillus licheniformis X39, activity value is MIC = 37.5 uM||Anti-Rhodococcus rhodochrous X15, activity value is MIC = 9.5 uM||Anti-Enterococcus faecium 091299, activity value is MIC = 19 uM||Anti-E. faecalis 981, activity value is MIC = 19 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 9.5 uM||Anti-Slime mould 090223, activity value is MIC = 1.2 uM||Anti-Candida albicans ATCC2002, activity value is MIC = 19||Anti-Gram+ & Gram-||Antifungal||candidacidal Odorrana versabilis (Chinese bamboo leaf odorous frog) (Rana versabilis)|||skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia)|||skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia) N/A "skin secretions, Hainan odorous frog, Odorrana hainanensis (China, Asia)|||[Ref.22450466] LC50=75 uM against human erythrocytes|||Human erythrocytes were used to examine the hemolytic activi- ties, and the results were shown in Table 1. It is observed that all the antimicrobial peptides display a relatively low hemolytic activity against human erythrocytes in vitro. Especially the brevinin-2HS2 and temporin-HN5 show extremely low hemolytic activity." "Peptides. 2012 Jun;35(2):285-90. doi: 10.1016/j.peptides.2012.03.007. Epub 2012 Mar 16.|||Peptides. 2006 Jan;27(1):42-48.||Ref.22450466|||16139929||Ref.22450466|||Peptides . 2012 Jun;35(2):285-90. doi: 10.1016/j.peptides.2012.03.007. Epub 2012 Mar 16.|||Peptides. 2012 Jun;35(2):285-90. PubMed." 24 FPDB02777 AP01963|||Laterosporulin|||AP01963 ACQCPDAISGWTHTDYQCHGLENKMYRHVYAICMNGTQVYCRTEWGSSC Active against B. subtilis (MIC ~2 uM)||S. aureus (MIC ~2 uM)||E. coli (MIC ~7 uM)||V. cholerae||P. aeruginosa (MIC ~15 uM)||and L. monocytogenes (MIC ~22 uM). The 3D structure is determined by crystallographic method at 2 A Singh PK et al.||2015. It consists of 4 beta-strands forming a twisted sheet. The peptide has a disulfide bond pattern similar to beta defensins and a structural scaffold like alpha-defensins. You can rotate||zoom||and view the 3D structure here in the PDB. Updated 6/2015; Jan2016; 7/2021||Antibacterial ; Bacillus subtillis||Staphylococcus aureus||Listeria monocytogenes||Pseudomonas aeruginosa||Escherichia coli||Vibrio cholerae||Anti-Gram+ & Gram-||Antifungal Brevibacillus sp. strain GI-9|||Brevibacillus laterosporus Strain GI-9 Beta Brevibacillus laterosporus Strain GI-9 "PLoS One. 2012;7(3):e31498. doi: 10.1371/journal.pone.0031498. Epub 2012 Mar 5.|||22403615|||PLoS One . 2012;7(3):e31498. doi: 10.1371/journal.pone.0031498. Epub 2012 Mar 5.|||PLoS One. 2012;7(3):e31498. PubMed." 49 FPDB02778 AP01965|||Hymenochirin-2B|||Hymenochirin-2B|||AP01965|||DRAMP04655|||AP01965 LKIPGFVKDTLKKVAKGIFSAVAGAMTPS Anti-K. pneumoniae and Gram-positive S. aureus, activity value is MIC = 20||Escherichia coli||Pseudomonas aeruginosa||Klebsiella pneumoniae||Staphylococcus aureus||Candida albicans||Anti-L. rhamnosus LGG, activity value is MIC = 250 ug/ml||Anti-L. casei R0215, activity value is MIC = 250 ug/ml||Anti-L. casei Shirota, activity value is MIC = 64 ug/ml||Anti-S. aureus DMS20231, activity value is MIC = 250 ug/ml||Anti-S. aureus Sens 8325.4, activity value is MIC = 16 ug/ml||Anti-S. aureus MRSA B33424, activity value is MIC = 32 ug/ml||Anti-S. pseudintermedium E138, activity value is MIC = 32 ug/ml||Anti-S. pseudintermedium E139, activity value is MIC = 32 ug/ml||Anti-S. pseudintermedium E140, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa 26228, activity value is MIC = 256 ug/ml||Anti-P. aeruginosa 25467, activity value is MIC = 256 ug/ml||Anti-P. aeruginosa Sens 2 ATCC27853, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa MDR1 B38084, activity value is MIC = 64 ug/ml||Anti-P. aeruginosa MDR2 B31770, activity value is MIC = 64 ug/ml||Anti-E. faecium Sens S1, activity value is MIC = 32 ug/ml||Anti-E. faecium Sens S2, activity value is MIC = 64 ug/ml||Anti-E. faecium VanA R39, activity value is MIC = 128 ug/ml||Anti-A. baumannii MDR Bangl 027, activity value is MIC = 64 ug/ml||Antibacterial||Antifungal||No MICs found in DRAMP database||Anti-Gram+ & Gram- Hymenochirus boettgeri [Congo dwarf clawed frog]|||Hymenochirus boettgeri|||Hymenochirus boettgeri [Congo dwarf clawed frog]|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa|||Hymenochirus boettgeri|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa N/A "Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa||LC₅₀ > 300 µM (mild hemolysis)|||The abilities of the synthetic hymenochirins to inhibit the growth of reference strains of the Gram-positive bacterium S. aureus, the Gram-negative bacteria E. coli, K. pneumoniae, and P. aeruginosa, and the opportunistic yeast pathogen C. albicans are compared in Table 1. The MIC values for hymenochirin-5B may be artefactually high because of the restricted solubility of the peptide in Mueller-Hinton broth and its tendency to form a gel in con- centrated solution. All peptides displayed relatively low hemolytic activities against human erythrocytes (LC50 in the range 160 to >301 ␮M).|||No hemolysis information or data found in the reference(s) presented in this entry" "Peptides. 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 3.|||22497805|||31102497|||22497805|||Peptides . 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 3.|||Peptides. 2012 Jun;35(2):269-275.|||Peptides. 2012 Jun;35(2):269-75. PubMed." 29 FPDB02779 AP01966|||Hymenochirin-3B|||Hymenochirin-3B|||AP01966|||DRAMP04656|||AP01966 IKIPAVVKDTLKKVAKGVLSAVAGALTQ Anti-K. pneumoniae and Gram-positive S. aureus, activity value is MIC = 20||Escherichia coli||Pseudomonas aeruginosa||Klebsiella pneumoniae||Staphylococcus aureus||Candida albicans||Antibacterial||Antifungal||No MICs found in DRAMP database||Anti-Gram+ & Gram- Hymenochirus boettgeri [Congo dwarf clawed frog]|||Hymenochirus boettgeri [Congo dwarf clawed frog]|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa|||Hymenochirus boettgeri|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa N/A "Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa||LC₅₀ > 300 µM (mild hemolysis)|||The abilities of the synthetic hymenochirins to inhibit the growth of reference strains of the Gram-positive bacterium S. aureus, the Gram-negative bacteria E. coli, K. pneumoniae, and P. aeruginosa, and the opportunistic yeast pathogen C. albicans are compared in Table 1. The MIC values for hymenochirin-5B may be artefactually high because of the restricted solubility of the peptide in Mueller-Hinton broth and its tendency to form a gel in con- centrated solution. All peptides displayed relatively low hemolytic activities against human erythrocytes (LC50 in the range 160 to >302 ␮M).|||No hemolysis information or data found in the reference(s) presented in this entry" "Peptides. 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 3.|||22497805|||22497805|||Peptides . 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 4.|||Peptides. 2012 Jun;35(2):269-275.|||Peptides. 2012 Jun;35(2):269-75. PubMed." 28 FPDB02780 AP01967|||Hymenochirin-4B|||Hymenochirin-4B|||AP01967|||DRAMP04657|||AP01967 IKIPAFVKDTLKKVAKGVISAVAGALTQ Anti-K. pneumoniae and Gram-positive S. aureus, activity value is MIC = 20 uM||Escherichia coli||Pseudomonas aeruginosa||Klebsiella pneumoniae||Staphylococcus aureus||Candida albicans||Anti-L. rhamnosus LGG, activity value is MIC = 250 ug/ml||Anti-L. casei R0215, activity value is MIC = 250 ug/ml||Anti-L. casei Shirota, activity value is MIC = 64 ug/ml||Anti-S. aureus DMS20231, activity value is MIC = 128 ug/ml||Anti-S. aureus Sens 8325.4, activity value is MIC = 16 ug/ml||Anti-S. aureus MRSA B33424, activity value is MIC = 16 ug/ml||Anti-S. pseudintermedium E138, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa Sens 2 ATCC27853, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa MDR1 B38084, activity value is MIC = 64 ug/ml||Anti-P. aeruginosa MDR2 B31770, activity value is MIC = 32 ug/ml||Anti-E. faecium Sens S1, activity value is MIC = 64 ug/ml||Anti-E. faecium Sens S2, activity value is MIC = 64 ug/ml||Anti-E. faecium VanA R39, activity value is MIC = 128 ug/ml||Anti-A. baumannii MDR Bangl 027, activity value is MIC = 32 ug/ml||Antibacterial||Antifungal||No MICs found in DRAMP database||Anti-Gram+ & Gram- Hymenochirus boettgeri [Congo dwarf clawed frog]|||Hymenochirus boettgeri|||Hymenochirus boettgeri [Congo dwarf clawed frog]|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa|||Hymenochirus boettgeri|||Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa N/A "Congo dwarf clawed frog, African dwarf frog, Hymenochirus boettgeri, Africa|||The abilities of the synthetic hymenochirins to inhibit the growth of reference strains of the Gram-positive bacterium S. aureus, the Gram-negative bacteria E. coli, K. pneumoniae, and P. aeruginosa, and the opportunistic yeast pathogen C. albicans are compared in Table 1. The MIC values for hymenochirin-5B may be artefactually high because of the restricted solubility of the peptide in Mueller-Hinton broth and its tendency to form a gel in con- centrated solution. All peptides displayed relatively low hemolytic activities against human erythrocytes (LC50 in the range 160 to >303 ␮M).|||No hemolysis information or data found in the reference(s) presented in this entry" "Peptides. 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 3.|||22497805|||31102497|||22497805|||Peptides . 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 5.|||Peptides. 2012 Jun;35(2):269-275.|||Peptides. 2012 Jun;35(2):269-75. PubMed." 28 FPDB02782 AP01969|||Antimicrobial peptide GP-19|||DRAMP02398|||Antimicrobial peptide GP-19|||AP01969|||DRAMP02398|||AP01969 GPVGLLSSPGSLPPVGGAP Diffusion assays (20 ug peptide): Active against B. subtilis (inhibition diameter: 19.04 mm)||X. campestris pv. Vesicatoria (16.47 mm)||P. solanacearum (10.75 mm)||P. wickerhami (10.3 mm)||B. megaterium (7.3 mm). Active against fungi: P. capsici (23.06% inhibition)||V. dahliae (52.46% inhibition)||F. graminearum (23.94% inhibition)||and F. omysporum (14.6% inhibition). Interstingly||the same peptide has also been identified in Lactobacillus crustorum MN047 . Inhibition zone assays reveal broad-spectrum activity. active against Gram+ S. aureus ATCC 29213||25923 (19.1-19.2 mm)||E. faecalis ATCC 29212 (10.3 mm)||L. monocytogenes CMCC 54004 (17.2 mm)||Gram- E. coli ATCC 25922 (17.0 mm)||Salmonella CMCC 50071 (18.7 mm)||C. sakazakii ATCC 29544 (18 mm)||also active against antibiotic0resistant C. sakazakii (16.9-18.4 mm) and Salmonella 557D (15.6 mm). Found in multiple species. Updated 7/2021||Bacillus subtilis (19.04 +/- 0.2mm diameter at 20 ug )||Xanthomonas campestris pv. Vesicatoria (16.47+/- 0.35mm diameter at 20 ug )||Pseudomonas solanacearum (10.75+/- 0.41mm diameter at 20 ug )||Prototheca wickerhamii (10.3+/- 0.33mm diameter at 20 ug )||Bacillus megaterium (7.3+/- 0.28mm diameter at 20 ug )||Phytophthora capsici (16.62 1.07mm colony diameter at 20 ug )||Verticillium dahliae (15.45 0.59mm colony diameter at 20 ug )||Fusarium graminearum (12.04 0.87mm colony diameter at 20 ug )||Fusarium omysporum (21.64 0.4mm colony diameter at 20 ug )||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||Antifungal ; Bacillus subtilis (19.04 +/- 0.2mm diameter at 20 ug )||Anti-Gram+ & Gram- Xenorhabdus budapestensis|||Xenorhabdus budapestensis|||Xenorhabdus budapestensis NMC-10, also Lactobacillus crustorum MN047|||Xenorhabdus budapestensis NMC-10, also Lactobacillus crustorum MN047 N/A "Xenorhabdus budapestensis NMC-10, also Lactobacillus crustorum MN047|||The abilities of the synthetic hymenochirins to inhibit the growth of reference strains of the Gram-positive bacterium S. aureus, the Gram-negative bacteria E. coli, K. pneumoniae, and P. aeruginosa, and the opportunistic yeast pathogen C. albicans are compared in Table 1. The MIC values for hymenochirin-5B may be artefactually high because of the restricted solubility of the peptide in Mueller-Hinton broth and its tendency to form a gel in con- centrated solution. All peptides displayed relatively low hemolytic activities against human erythrocytes (LC50 in the range 160 to >304 ␮M)." "Peptides. 2012 Jun;35(2):269-75. doi: 10.1016/j.peptides.2012.03.029. Epub 2012 Apr 3.||Yi et al., 2018|||22497806|||Peptides. 2012 Jun;35(2):253-260.|||22497806|||Peptides . 2012 Jun;35(2):253-60. doi: 10.1016/j.peptides.2012.03.027. Epub 2012 Apr 3.||Yi et al., 2018|||Peptides. 2012 Jun;35(2):253-260.|||Peptides. 2012 Jun;35(2):253-60. PubMed." 19 FPDB02785 AP01973|||Oh-defensin|||DRAMP01370|||AP01973|||DRAMP01370|||AP01973 MLCKLSMFGAVLGVPACAIDCLPMGKTGGSCEGGVCGCRKLTFKILWDKKFG Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 1.25 ug/ml||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Escherichia coli, activity value is MIC = 1.25 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 1.25 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 5 ug/ml Haplopelma hainanum [Chinese bird spider]|||Ornithoctonus hainana (Venoms)|||Venoms, Ornithoctonus hainana, Brazil, South America|||Ornithoctonus hainana (Venoms)|||Venoms, Ornithoctonus hainana, Brazil, South America Bridge Venoms, Ornithoctonus hainana|||In 5 (Study on Antimicrobial Peptides of Hainan Tarantula Spider Venom Defensins), using rabbit red blood cells as the test subject, Oh-defensin at a concentration of 200 μg/ml (approximately 36 μM) had a hemolysis rate of only 7%, indicating very low hemolytic activity.|||[Ref.21538709] It has little hemolytic activity, inducing 7% hemolysis at the concentration up to 200 ug/ml (about 36 uM).|||Oh-defensin showed strong antimicrobial activities against all the tested microorganisms including Gram-positive bacteria, Gram-negative bacteria, and fungus (Table 1). Among the tested microorganisms, it showed potent antimicrobial activities against S. aureus, E. coli, Bacillus dysenteriae, and C. albcans with MIC of 1.25 ug/ml. It had weakest antimicrobial ability against B. cereus (MIC 25 ug/ml). The antibiotic activity was proved to be lethal for the sensitive strain. The sensitive strains were not capable of resuming growth on agar plates after a 6-h treatment with concentrations above the corresponding MICs. Some antimicrobial peptides reportedly have hemolytic activities [21,22]. Rabbit red blood cells were used to examine the sample’s hemolytic capability. The result indicated that Ohdefensin had little hemolytic activity, only inducing 7% hemolysis at the concentration up to 200 ug/ml (about 36 uM) compared with 1% Triton X-100 which could induce 100% hemolysis.|||[Ref.21538709] It has little hemolytic activity, inducing 7% hemolysis at the concentration up to 200 ug/ml (about 36 uM). "J Pept Sci. 2011 Jul;17(7):540-4. doi: 10.1002/psc.1370. Epub 2011 Apr 28.|||21538709|||J Pept Sci. 2011 Jul;17(7):540-544|||21538709|||J Pept Sci . 2011 Jul;17(7):540-4. doi: 10.1002/psc.1370. Epub 2011 Apr 28.|||J Pept Sci. 2011 Jul;17(7):540-4. doi: 10.1002/psc.1370. PubMed" 52 FPDB02789 AP01979|||Antimicrobial peptide 1|||DRAMP00392|||Antimicrobial peptide 1|||AP01979|||DRAMP00392|||AP01979 VAKCTEESGGKYFVFCCYKPTRICYMNEQKCESTCIGK Anti-and Gram+ B. subtilis loaded 0.03 ml at 6 ug/ul . Also active against fungi B. cinerea, activity value is IC50 = 5.8 uM||Anti-A. niger, activity value is IC50 = 5.6 uM||Anti-and P-debaryanum, activity value is IC50 > 10 uM||Antibacterial||Antifungal||Antimicrobial||Anti-B. cinerea, activity value is MIC = 5.8 uM||Anti-A. niger, activity value is MIC = 5.6 uM||Anti-Gram+ & Gram- Taraxacum officinale [Common dandelion]|||Taraxacum officinale (Common dandelion) (Leontodon taraxacum)|||Taraxacum officinale [Common dandelion]|||dandelion Taraxacum officinale Wigg. flowers|||Taraxacum officinale (Common dandelion) (Leontodon taraxacum)|||dandelion Taraxacum officinale Wigg. flowers Bridge dandelion Taraxacum officinale Wigg. flowers "Peptides. 2012 Aug;36(2):266-71. doi: 10.1016/j.peptides.2012.05.009. Epub 2012 May 26.|||22640720|||Peptides. 2012 Aug;36(2):266-271.|||22640720|||Int J Pept . 2009:2009:136284. doi: 10.1155/2009/136284. Epub 2009 Oct 22.|||Peptides. 2012 Aug;36(2):266-271.|||Anti-Gram+ & Gram-, Antifungal" 38 FPDB02790 AP01980|||IsCT2|||IsCT2|||AP01980|||DRAMP03722|||AP01980 IFGAIWNGIKSLF Anti-Gram+ S. aureus ATCC 25293, activity value is MIC = 0.7 uM||Anti-S. aureus ATCC 6538, activity value is MIC = 3.4 uM||Anti-S. saprophyticus clincal strain, activity value is MIC = 0.7 uM||Anti-B. thuringensis, activity value is MIC = 17.1 uM||Anti-P.aeroginosa ATCC 15442, activity value is MIC > 150 uM||Anti-P. aeroginosa ATCC 27853, activity value is MIC = 68.3 uM||Anti-E. coli CCT 1371, activity value is MIC = 3.4 uM||Anti-E. coli ATCC 25922, activity value is MIC = 6.8 uM||Anti-P.mirabilis, activity value is MIC > 150 uM||Anti-and C. albicans, activity value is MIC = 12.5 uM||Antibacterial||Antifungal||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-S. typhimurium, activity value is MIC = 100 ug/ml||Anti-E. coli, activity value is MIC = 50 ug/ml||Anti-negetive bacteria: P.aeroginosa ATCC 15442, activity value is MIC > 150 uM||Anti-P.aeroginosa ATCC 27853, activity value is MIC = 68.3 uM||Anti-E.coli CCT 1371, activity value is MIC = 3.4 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6.8 uM||Anti-P. mirabilis, activity value is MIC > 150 uM||Anti-S.aureus ATCC 25293, activity value is MIC = 0.7 uM||Anti-S.aureus ATCC 6538, activity value is MIC = 3.4 uM||Anti-S.saprophyticus, activity value is MIC = 0.7 uM||Anti-B.thuringensis, activity value is MIC = 17.1 uM||Anti-B.subtilis CCT 2471, activity value is MIC = 6.8 uM||Anti-Escherichia coli, activity value is MIC = 50 ug/ml||Anti-Gram+ & Gram-||candidacidal Opisthacanthus madagascariensis [Scorpion]|||Synthetic construct|||Opisthacanthus madagascariensis [Scorpion]|||venom, Opisthacanthus madagascariensis, Africa|||Opisthacanthus madagascariensis (Scorpion)|||venom, Opisthacanthus madagascariensis, Africa Helix "venom, Opisthacanthus madagascariensis|||Human erythrocytes (100% hemolysis at 100 ug/ml)|||[Ref.12054688] Showed relatively weak hemolytic activity against sheep red blood cells. [Ref.28657596] 18% hemolysis at 10 ug/ml, 96% hemolysis at 50 ug/ml against human red blood cells.|||20% hemolysis at 200 uM" "Biochem Biophys Res Commun. 2002 May 24;293(5):1514-22. doi: 10.1016/S0006-291X(02)00423-0.|||20575512|||28657596|||20575512|||Biochem Biophys Res Commun . 2002 May 24;293(5):1514-22. doi: 10.1016/S0006-291X(02)00423-0.|||Ref.12054688||Ref.28657596|||Biochem Biophys Res Commun. 2002 May 24;293(5):1514-22.PubMed" 13 FPDB02791 AP01981|||DRAMP00391|||AP01981|||DRAMP00391 GGKCTVDWGGQGGGRRLPSPLFCCYKPTRICYLNQETCETETCP Anti-and B. subtilis . Also active against fungi B. cinerea, activity value is IC50 = 5.2 uM||Anti-A. niger, activity value is IC50 = 2.6 uM||Anti-B. sorokiniana, activity value is IC50 = 5.2 uM||Anti-P. debaryanum, activity value is IC50 = 2.6 uM||Anti-but no activity below 10 uM against F-oxysporum and F-graminearum, activity value is IC50 > 10 uM||Antimicrobial||Antibacterial||Antifungal||Anti-Gram+ & Gram- Taraxacum officinale (Common dandelion) (Leontodon taraxacum)|||dandelion Taraxacum officinale Wigg. flowers|||Taraxacum officinale (Common dandelion) (Leontodon taraxacum)|||dandelion Taraxacum officinale Wigg. flowers Bridge dandelion Taraxacum officinale Wigg. flowers "Peptides. 2012 Aug;36(2):266-71. doi: 10.1016/j.peptides.2012.05.009. Epub 2012 May 26.|||Peptides. 2012 Aug;36(2):266-271.|||Peptides . 2012 Aug;36(2):266-71. doi: 10.1016/j.peptides.2012.05.009. Epub 2012 May 26.|||Peptides. 2012 Aug;36(2):266-271.|||Peptides. 2012 Aug;36(2):266-71. May 25 online.PubMed" 44 FPDB02792 AP01982|||Antimicrobial peptide 3|||DRAMP00390|||AP01982|||DRAMP00390|||AP01982 ANKCIIDCMKVKTTCGDECKGAGFKTGGCALPPDIMKCCHNC Anti-and Gram+ B. subtilis . Also active against fungi F. oxysporum, activity value is IC50 = 5.7 uM||Anti-A. niger, activity value is IC50 = 1.2 uM||Antibacterial||Antifungal||Antimicrobial||Anti-Gram+ & Gram- Taraxacum officinale [Common dandelion]|||Taraxacum officinale (Common dandelion) (Leontodon taraxacum)|||dandelion Taraxacum officinale Wigg. flowers|||Taraxacum officinale (Common dandelion) (Leontodon taraxacum)|||dandelion Taraxacum officinale Wigg. flowers Bridge dandelion Taraxacum officinale Wigg. flowers "Peptides. 2012 Aug;36(2):266-71. doi: 10.1016/j.peptides.2012.05.009. Epub 2012 May 26.|||22640720|||Peptides. 2012 Aug;36(2):266-271.|||Peptides . 2012 Aug;36(2):266-71. doi: 10.1016/j.peptides.2012.05.009. Epub 2012 May 26.|||Peptides. 2012 Aug;36(2):266-271.|||Peptides. 2012 Aug;36(2):266-71. May 25 online.PubMed" 42 FPDB02811 AP02020|||Brevinin-1-AJ1 antimicrobial peptide precursor|||Brevinin-1-AJ1 antimicrobial peptide precursor|||AP02020|||AP02020 FLSTLLKVAFKVVPTLFCPITKKC Anti-Gram- E. coli ATCC 25922, activity value is MIC = 18.75 ug/ml||Anti-B. dysenteriae, activity value is MIC = 9.38 ug/ml||Anti-S. aureus ATCC 2592, activity value is MIC = 1.17 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC = 4.7 ug/ml||Anti-and fungi C. albicans ATCC 2002, activity value is MIC = 4.7 ug/ml||Antibacterial||Antifungal||Anti-E. coli ATCC 25922, activity value is MIC = 18.75 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 4.7 ug/ml||Anti-Gram+ & Gram-||candidacidal||Hemolytic Amolops chunganensis [Chungan torrent frog]|||Amolops jingdongensis [Chinese torrent frog]|||Skin, the torrent frog, Amolops jingdongensis, South China, Asia|||Skin, the torrent frog, Amolops jingdongensis, South China, Asia N/A Skin, the torrent frog, Amolops jingdongensis, South China, Asia||HC₅₀ = 7.3 uM。|||Rabbit erythrocytes 7.62% lysis (25 ug/ml)|||Rabbit erythrocytes 7.62% lysis (25 ug/ml)|||24.58% hemolysis at 50 UM and 83.05% hemolysis at 100 uM "Amino Acids. 2012 Jul 25. online. 2013 Feb;44(2):481-7. doi: 10.1007/s00726-012-1358-z. Epub 2012 Jul 25.|||22828809|||22828809|||Amino Acids . 2013 Feb;44(2):481-7. doi: 10.1007/s00726-012-1358-z. Epub 2012 Jul 25.|||Amino Acids. 2012 Jul 25. online. PubMed" 24 FPDB02812 AP02021|||Temporin-AJ8 antimicrobial peptide precursor|||DRAMP01748|||Temporin-AJ8 antimicrobial peptide precursor|||AP02021|||AP02021 FFPIVGKRLYGLL Anti-E. coli ATCC 25922, activity value is MIC = 70 ug/ml||Anti-B. dysenteriae, activity value is MIC = 18.75 ug/ml||Anti-S. aureus ATCC 2592, activity value is MIC = 4.7 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC = 9.38 ug/ml||Anti-and fungi C. albicans ATCC 2002, activity value is MIC = 37.5 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 37.5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 70 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 4.7 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 9.38 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 37.5 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Amolops jingdongensis [Chinese torrent frog]|||Amolops jingdongensis (torrent frog)|||Amolops jingdongensis [Chinese torrent frog]|||Skin, the torrent frog, Amolops jingdongensis, South China, Asia|||Skin, the torrent frog, Amolops jingdongensis, South China, Asia N/A Skin, the torrent frog, Amolops jingdongensis, South China, Asia||At a concentration of 128 μM, the hemolysis rate ≈ 10%.|||Rabbit erythrocytes 1.79% lysis (25 ug/ml)|||Among the antimicrobial peptides isolated from the skin secretions of ops jingdongensis, brevinin-1-AJ1 had a hemolysis rate of 7.62% at a concentration of 25 µg/ml, 24.58% at 50 µg/ml, 83.05% at 100 µg/ml, and 87.65% at 200 µg/ml; temporin-AJ8 had a hemolysis rate of 1.79% at 25 µg/ml, 5.22% at 50 µg/ml, 7.92% at 100 µg/ml, and 10.85% at 200 µg/ml; jingdongin-1 had a hemolysis rate of 1.32% at 50 µg/ml, 5.37% at 100 µg/ml, and 16.55% at 200 µg/ml; jingdongin-2 had a hemolysis rate of 0.7% at 25 µg/ml, 1.1% at 50 µg/ml, 2.6% at 100 µg/ml, and 3|||[Ref.22828809] 1.79% hemolysis at 25 ug/ml, 5.22% hemolysis at 50 ug/ml, 7.92% hemolysis at 100 ug/ml, 10.85% hemolysis at 200 ug/ml against rabbit red blood cells|||Rabbit erythrocytes 1.79% lysis (25 ug/ml)|||poor hemo.lytic (HC50>200 uM). "Amino Acids. 2012 Jul 25. online. 2013 Feb;44(2):481-7. doi: 10.1007/s00726-012-1358-z. Epub 2012 Jul 25.|||22828809|||Amino Acids. 2012 Jul 25.||Ref.22828809|||22828809||Ref.22828809|||22828809|||Amino Acids . 2013 Feb;44(2):481-7. doi: 10.1007/s00726-012-1358-z. Epub 2012 Jul 25.|||Amino Acids. 2012 Jul 25. online. PubMed" 13 FPDB02813 AP02022|||Jingdongin-1 antimicrobial peptide precursor|||DRAMP18185|||Jingdongin-1 antimicrobial peptide precursor|||AP02022|||AP02022 FLPLFLPKIICVITKKC Anti-E.coli ATCC 25922, activity value is MIC > 200 ug/ml||Anti-B. dysenteriae, activity value is MIC = 35 ug/ml||Anti-S. aureus ATCC 2592, activity value is MIC = 4.7 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC = 9.38 ug/ml||Anti-and fungi C. albicans ATCC 2002, activity value is MIC = 18.75 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 18.75 ug/ml||Anti-B.dysenteriae, activity value is MIC = 35 ug/ml||Anti-S.aureus ATCC 2592, activity value is MIC = 4.7 ug/ml||Anti-B.subtilis ATCC 6633, activity value is MIC = 9.38 ug/ml||Anti-Fungus: C.albicans, activity value is MIC = 18.75 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Amolops jingdongensis (Chinese torrent frog)|||Skin, the torrent frog, Amolops jingdongensis, South China, Asia|||Skin, the torrent frog, Amolops jingdongensis, South China, Asia N/A "Skin, the torrent frog, Amolops jingdongensis, South China, Asia||At a concentration of 40 μM, the hemolysis rate is < 10%.|||Rabbit erythrocytes 1.32% lysis (25 ug/ml)|||brevinin-1-AJ1: Hemolysis rate of 7.62% at 25 µg/ml, 24.58% at 50 µg/ml, 83.05% at 100 µg/ml, 87.65% at 200 µg/ml, strongest hemolytic activity. temporin-AJ8: Hemolysis rate of 1.79% at 25 µg/ml, 5.22% at 50 µg/ml, 7.92% at 100 µg/ml, 10.85% at 200 µg/ml, relatively low hemolytic activity. jingdongin-1: Hemolysis rate of 1.32% at 25 µg/ml, 5.37% at 50 µg/ml, 6.35% at 100 µg/ml, 16.55% at 200 µg/ml, moderate to low hemolytic activity. jingdongin-2: Hemolysis rate of 0.7% at 25 µg/ml, 1.1% at 50 µg/ml, 2.6% at 100 µg/ml, 3.7% at 200 µg/ml, weakest hemolytic activity.|||Rabbit erythrocytes 1.32% lysis (25 ug/ml)|||poor hemo.lytic (HC50>200 uM)." "Amino Acids. 2012 Jul 25. online. 2013 Feb;44(2):481-7. doi: 10.1007/s00726-012-1358-z. Epub 2012 Jul 25.|||22828809|||Amino Acids 44:481-487(2013)||Ref.22828809|||22828809|||Amino Acids . 2013 Feb;44(2):481-7. doi: 10.1007/s00726-012-1358-z. Epub 2012 Jul 25.|||Amino Acids. 2012 Jul 25. online. PubMed" 17 FPDB02819 AP02031|||DRAMP04665|||Px-cec1|||AP02031 KPFKKLEKVGRNIRDGIIKAGPAVAVIGQATSIARPTGK Anti-Gram+ S. aureus, activity value is MIC = 2.1 uM||Anti-B. cereus, activity value is MIC = 2.6 uM||Anti-E. coli K12D31 or K12, activity value is MIC = 0.1||Anti-P. fluorescent, activity value is MIC = 1.1 uM||Anti-S. choleraesuis, activity value is MIC = 2.1 uM||Anti-A. pullulans, activity value is MIC = 4 uM||Anti-A. flavus, activity value is MIC = 14.5 uM||Anti-A. fumigatus, activity value is MIC = 16 uM||Anti-A. niger, activity value is MIC = 14.6 uM||Anti-and F. oxysporum, activity value is MIC = 8 uM||Anti-S. aureus, activity value is MIC = 2 uM||Anti-E. coli, activity value is MIC = 0.1 uM||Anti-Pseudomonas fluorescent, activity value is MIC = 1.1 uM||Anti-Salmonella choleraesuis, activity value is MIC = 2.1 uM||Anti-Aureobasidium pullulans, activity value is MIC = 4 uM||Anti-Aspergillus flavus, activity value is MIC = 14.5 uM||Anti-Aspergillus fumigatus, activity value is MIC = 16 uM||Anti-Aspergillus niger, activity value is MIC = 14.6 uM||Anti-Fusarium oxysporum, activity value is MIC = 8 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram- Plutella xylostella (Diamondback moth)|||Plutella xylostella L [Diamondback moth]|||diamondback moth, Plutella xylostella L.|||diamondback moth, Plutella xylostella L. Helix||Alpha helix (CD) diamondback moth, Plutella xylostella L.||At a concentration of 100 µM, the hemolysis rate is approximately 4%.|||No hemolytic activity against human erythrocytes "Protein Expr Purif. 2012 Oct;85(2):230-8. doi: 10.1016/j.pep.2012.08.006.|||Protein Expr Purif. 2012 Oct;85(2):230-238.||Ref.22921836|||22921836|||Protein Expr Purif . 2012 Oct;85(2):230-8. doi: 10.1016/j.pep.2012.08.006. Epub 2012 Aug 17.|||Protein Expr Purif. 2012 Oct;85(2):230-8. doi: 10.1016/j.pep.2012.08.006. PubMed" 39 FPDB02820 AP02033|||LTP110|||AP02033 VSCGDVTSSIAPCLSYVMGRESSPSSSCCSGVRTLNGKASSSADRRTACSCLKNMASSFRNLNMGNAASIPSKCGVSVAFPISTSVDCSKIN Anti-whic causes blight disease in rice. It completely inhibited P. syringgae, activity value is MIC = 27 ug/ml||Antibacterial||Antifungal ; Pyricularia oryzae||Xanthomonas oryzae||Anti-Gram-||Antifungal Oryza sativa [Rice]|||rice leaves, Oryza sativa Indica Group N/A rice leaves, Oryza sativa Indica Group "J Biochem Mol Biol. 2003 Nov 30;36(6):603-7. doi: 10.5483/bmbrep.2003.36.6.603.|||14659081|||J Biochem Mol Biol . 2003 Nov 30;36(6):603-7. doi: 10.5483/bmbrep.2003.36.6.603.|||J Biochem Mol Biol. 2003 Nov 30;36(6):603-7. PubMed" 92 FPDB02823 AP02041 KSCCKSTLGRNCYNLCRARGAQKLCANVCRCKLTSGLSCPKDFPK Anti-the peptide showed activity against pathogens of plant origin. Crude active against S. uvarum CC-21, activity value is MIC = 32 ug/ml||Anti-S. uvarum CC-23, activity value is MIC < 4 ug/ml||Anti-S. cerevisiae, activity value is MIC = 8 ug/ml||Anti-A. pisi, activity value is IC50 = 3 ug/ml||Anti-B. cinerea, activity value is IC50 = 12 ug/ml||Anti-C. lindemuthianum, activity value is IC50 = 15 ug/ml||Anti-F. culmorum, activity value is IC50 = 1 ug/ml||Anti-F. oxysporum, activity value is IC50 = 0.5 ug/ml||Anti-N. haematococca, activity value is IC50 = 1 ug/ml||Anti-P. betae, activity value is IC50 = 4 ug/ml||Anti-P. tritici-repentis, activity value is IC50 = 4 ug/ml||Anti-V. dahliae, activity value is IC50 = 0.5 ug/ml||Anti-V. inaequalis, activity value is IC50 = 5 ug/ml||Anti-B. megaterium, activity value is IC50 = 1 ug/ml||Anti-E.carotovora, activity value is IC50 > 500 ug/ml||Anti-E.coli, activity value is IC50 = 250 ug/ml||Anti-and S. lutea, activity value is IC50 = 5 ug/ml||Anti-Gram+||Antifungal||Hemolytic wheat, Triticum aestivum Combine Helix and Beta structure wheat, Triticum aestivum "Appl Microbiol. 1974 Aug;28(2):165-8. doi: 10.1128/am.28.2.165-168.1974.|||Appl Microbiol . 1974 Aug;28(2):165-8. doi: 10.1128/am.28.2.165-168.1974.|||Appl Microbiol. 1974 Aug;28(2):165-8. Pub-Med." 45 FPDB02825 AP02050 FFHHIFRGIVHVGKTIHRLVTGT Anti-A synthetic peptide was found to be active against E. coli, activity value is MIC = 10 uM||Anti-S. aureus, activity value is MIC = 5 uM||Anti-C. albicans, activity value is MIC = 20 uM||Anti-and P. acnes, activity value is MIC = 10 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA skin/gill, Morone saxatilis N/A skin/gill, Morone saxatilis||HC₅₀ ≈ 2 uM。 "J Biol Chem. 2002 Feb 15;277(7):5030-9. doi: 10.1074/jbc.M109173200. Epub 2001 Dec 5.||Wu et al., 2020|||J Biol Chem . 2002 Feb 15;277(7):5030-9. doi: 10.1074/jbc.M109173200. Epub 2001 Dec 5.||Wu et al., 2020|||J Biol Chem. 2002 Feb 15;277(7):5030-9. Pub-Med." 23 FPDB02827 AP02052|||Sclerosin|||Sclerosin|||AP02052|||DRAMP18313|||AP02052 TPALAVVTTVLPAAAVTTAKSV Active against the fungal pathogen S. sclerotiorum that infects plants. Updated 7/2021||Antibacterial||Antifungal||Antifungal ; Sclerotinia sclerotiorum||Bacillus species||Active against the fungal pathogen S. sclerotiorum that infects plants.||Antimicrobial||Anti-Gram+ Pseudomonas sp. strain DF41|||Pseudomonas brassicacearum strain DF41 N/A Pseudomonas brassicacearum strain DF41 "Can J Microbiol. 2012 Aug;58(8):1027-34. doi: 10.1139/w2012-079.|||22838838|||22838838|||Can J Microbiol . 2012 Aug;58(8):1027-34. doi: 10.1139/w2012-079.|||Can J Microbiol. 2012 Aug;58(8):1027-34.|||Can J Microbiol. 2012 Aug;58(8):1027-34.Pub-Med." 22 FPDB02829 AP02054|||DRAMP01725 FLPFVGNLLKGLL Anti-Primarily active against Gram-positive bacteria: R. rhodochrous X15, activity value is MIC = 9 uM||Anti-B. licheniformis X39, activity value is MIC = 19 uM||Anti-E. faecalis 981, activity value is MIC = 19 uM||Anti-S. carnosus KHS, activity value is MIC = 19 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 9 uM||Anti-E.coli ATCC 25922, activity value is MIC > 150 uM||Anti-P.aeruginosa CGMCC 1.50, activity value is MIC > 150 uM||Anti-P.aeruginosa 11053, activity value is MIC > 150 uM||Anti-K.pneumoniae 08040724, activity value is MIC > 150 uM||Anti-P. faecalis X29, activity value is MIC = 75 uM||Anti-S. rubidaea X01, activity value is MIC = 75 uM||Anti-C.albicans ATCC 10231, activity value is MIC > 150 uM||Anti-Slime mold 090223, activity value is MIC = 9 uM||Anti-B. licheniformis X39 IS, activity value is MIC = 19 uM||Anti-S. carnosus KHS IS, activity value is MIC = 19 uM||Anti-K.pneumoniae 08040724 IS, activity value is MIC > 150 uM||Anti-P. faecalis X29 IS, activity value is MIC = 75 uM||Anti-S. rubidaea X01 IS, activity value is MIC = 75 uM||Anti-Slime mold 090223 IS, activity value is MIC = 9 uM||Antimicrobial||Anti-Gram+ & Gram-||Antifungal skin secretions, Amolops chunganensis, China, Asia|||Amolops chunganensis (Chungan torrent frog) N/A skin secretions, Amolops chunganensis, China, Asia||HC₅₀ = 7.8 uM。|||less hemo.lytic to human RBC (HC50 >150 uM). "Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008.|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 19.|||Peptides. 2012 Nov;38(1):41-53.|||Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Pub-Med." 13 FPDB02832 AP02057 SLFSIFKTAAKFVGKNLLKQAGKAGLETLACKAKNEC Anti-Primarily active against Gram-positive bacteria: R. rhodochrous X15, activity value is MIC = 1.2 uM||Anti-B. licheniformis X39, activity value is MIC = 9 uM||Anti-E. faecalis 981, activity value is MIC = 19 uM||Anti-S. carnosus KHS, activity value is MIC = 1.2 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 9 uM||Anti-E. coli ATCC 25922, activity value is MIC = 75 uM||Anti-P.aeruginosa CGMCC 1.50, activity value is MIC > 150 uM||Anti-P.aeruginosa 11053, activity value is MIC > 150 uM||Anti-K.pneumoniae 08040724, activity value is MIC = 150 uM||Anti-P. faecalis X29, activity value is MIC = 4.5 uM||Anti-S. rubidaea X01, activity value is MIC = 1.2 uM||Anti-C.albicans ATCC 10231, activity value is MIC > 150 uM||Anti-Slime mold 090223, activity value is MIC = 4.5 uM||Anti-Gram+ & Gram-||Antifungal||Hemolytic skin secretions, Amolops chunganensis, China, Asia N/A skin secretions, Amolops chunganensis, China, Asia||HC₅₀ = 5.1 uM。|||moderate hemolytic to human RBC (HC50 75 uM) "Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008.|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 20.|||Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Pub-Med." 37 FPDB02833 AP02058|||DRAMP01239 GLWNTIKEAGKKFAINVLDKIRCGIAGGCKT Anti-Primarily active against Gram-positive bacteria: R. rhodochrous X15, activity value is MIC = 2.3 uM||Anti-B. licheniformis X39, activity value is MIC = 19 uM||Anti-E. faecalis 981, activity value is MIC = 75 uM||Anti-S. carnosus KHS, activity value is MIC = 19 uM||Anti-S.aureus ATCC 25923, activity value is MIC = 150 uM||Anti-E.coli ATCC 25922, activity value is MIC = 150 uM||Anti-P.aeruginosa CGMCC 1.50, activity value is MIC > 150 uM||Anti-P.aeruginosa 11053, activity value is MIC > 150 uM||Anti-K.pneumoniae 08040724, activity value is MIC = 150 uM||Anti-P. faecalis X29, activity value is MIC = 4.5 uM||Anti-S. rubidaea X01, activity value is MIC = 4.6 uM||Anti-C.albicans ATCC 10231, activity value is MIC > 150 uM||Anti-Slime mold 090223, activity value is MIC = 4.5 uM||Antimicrobial||Antibacterial||Anti-Gram+ & Gram-||Antifungal||Hemolytic skin secretions, Amolops chunganensis, China, Asia|||Rana chensinensis (Chinese brown frog) N/A skin secretions, Amolops chunganensis, China, Asia||At a concentration of 100 μM, the hemolysis rate is < 10%.|||moderate hemolytic to human RBC (HC50 75 uM). "Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008.|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 21.|||Zoolog Sci. 2011 Feb;28(2):112-117.|||Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Pub-Med." 31 FPDB02834 AP02059|||DRAMP01896|||AP02059 FLSTALKVAANVVPTLFCKITKKC Anti-Primarily active against Gram-positive bacteria: bacteria: R. rhodochrous X15, activity value is MIC = 9 uM||Anti-B. licheniformis X39, activity value is MIC = 75 uM||Anti-E.faecalis 981, activity value is MIC > 150 uM||Anti-S.carnosus KHS, activity value is MIC > 150 uM||Anti-S.aureus ATCC 25923, activity value is MIC > 150 uM||Anti-E.coli ATCC 25922, activity value is MIC = 150 uM||Anti-P.aeruginosa CGMCC 1.50, activity value is MIC > 150 uM||Anti-P.aeruginosa 11053, activity value is MIC > 150 uM||Anti-K.pneumoniae 08040724, activity value is MIC > 150 uM||Anti-P.faecalis X29, activity value is MIC > 150 uM||Anti-S.rubidaea X01, activity value is MIC > 150 uM||Anti-C.albicans ATCC 10231, activity value is MIC > 150 uM||Anti-Slime mold 090223, activity value is MIC = 75 uM||Anti-Rhodococcus rhodochrous X15, activity value is MIC = 9 uM||Anti-Bacillus licheniformis X39, activity value is MIC = 75 uM||Anti-Escherichia coli, activity value is MIC = 150 uM||Anti-Primarily active against Gram-positive bacteria: bacteria: R. rhodochrous X15 IS, activity value is MIC = 9 uM||Anti-B. licheniformis X39 IS, activity value is MIC = 75 uM||Anti-S.carnosus KHS IS, activity value is MIC > 150 uM||Anti-P.aeruginosa CGMCC 1.50 or 11053 IS, activity value is MIC > 150 uM||Anti-K.pneumoniae 08040724 IS, activity value is MIC > 150 uM||Anti-P.faecalis X29 IS, activity value is MIC > 150 uM||Anti-S.rubidaea X01 IS, activity value is MIC > 150 uM||Anti-Slime mold 090223 IS, activity value is MIC = 75 uM||Anti-Gram+||Antifungal Amolops chunganensis (Chungan torrent frog)|||skin secretions, Amolops chunganensis, China, Asia|||skin secretions, Amolops chunganensis, China, Asia N/A skin secretions, Amolops chunganensis, China, Asia||HC₅₀ = 4.2 uM。|||In Peptides 2012, among the antimicrobial peptides isolated from the skin secretions of the Chungan torrent frog (Amolops chunganensis), temporin-CG1, temporin-CG4, and temporin-CG5 all had LC₅₀ values greater than 150 µM for human red blood cells; temporin-CG2 and temporin-CG3 both had LC₅₀ values of 150 µM for human red blood cells; esculentin-2CG1, palustrin-2CG1, and brevinin-2CG1 all had LC₅₀ values of 75 µM for human red blood cells; brevinin-1CG1 had an LC₅₀ of 150 µM for human red blood cells, brevinin-1CG2, brevinin-1CG3, and brevinin-1CG5 all had LC₅₀ values of 19 µM for human red blood cells, and brevinin-1CG4 had an LC₅₀ of 37.5 µM for human red blood cells.|||highly hemolytic to human RBC (HC50 19 uM). "Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008.|||Peptides. 2012 Nov;38(1):41-53.|||22951323|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 22.|||Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Pub-Med." 24 FPDB02835 AP02060|||DRAMP01897|||AP02060 FLPIVAGLAANFLPKIVCKITKKC Anti-Primarily active against Gram-positive bacteria: R. rhodochrous X15, activity value is MIC = 1.2 uM||Anti-B. licheniformis X39, activity value is MIC = 9 uM||Anti-E. faecalis 981, activity value is MIC = 19 uM||Anti-S. carnosus KHS, activity value is MIC = 9 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 9 uM||Anti-E.coli ATCC 25922, activity value is MIC = 150 uM||Anti-P.aeruginosa CGMCC 1.50, activity value is MIC > 150 uM||Anti-P.aeruginosa 11053, activity value is MIC > 150 uM||Anti-K.pneumoniae 08040724, activity value is MIC > 150 uM||Anti-P. faecalis X29, activity value is MIC = 19 uM||Anti-S. rubidaea X01, activity value is MIC = 19 uM||Anti-C.albicans ATCC 10231, activity value is MIC = 150 uM||Anti-Slime mold 090223, activity value is MIC = 4.5 uM||Anti-Rhodococcus rhodochrous X15, activity value is MIC = 9 uM||Anti-Bacillus licheniformis X39, activity value is MIC = 75 uM||Anti-Enterococcus faecalis 981, activity value is MIC = 19 uM||Anti-Staphylococcus carnosus KHS, activity value is MIC = 9 uM||Anti-Staphylococcus aureus, activity value is MIC = 9 uM||Anti-Escherichia coli, activity value is MIC = 150 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 19 uM||Anti-Serratia rubidaea X01, activity value is MIC = 19 uM||Anti-Candida albicans, activity value is MIC = 150 uM||Anti-Gram+ & Gram-||Antifungal||Hemolytic Amolops chunganensis (Chungan torrent frog)|||skin secretions, Amolops chunganensis, China, Asia|||skin secretions, Amolops chunganensis, China, Asia N/A skin secretions, Amolops chunganensis, China, Asia||HC₅₀ = 6.7 uM。|||In Peptides 2012, among the antimicrobial peptides isolated from the skin secretions of the Chungan torrent frog (Amolops chunganensis), temporin-CG1, temporin-CG4, and temporin-CG5 all had LC₅₀ values greater than 150 µM for human red blood cells; temporin-CG2 and temporin-CG3 both had LC₅₀ values of 150 µM for human red blood cells; esculentin-2CG1, palustrin-2CG1, and brevinin-2CG1 all had LC₅₀ values of 75 µM for human red blood cells; brevinin-1CG1 had an LC₅₀ of 150 µM for human red blood cells, brevinin-1CG2, brevinin-1CG3, and brevinin-1CG5 all had LC₅₀ values of 19 µM for human red blood cells, and brevinin-1CG4 had an LC₅₀ of 37.5 µM for human red blood cells.|||highly hemolytic to human RBC (HC50 19 uM). "Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008.|||Peptides. 2012 Nov;38(1):41-53.|||22951323|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 23.|||Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Pub-Med." 24 FPDB02836 AP02061|||DRAMP01898|||AP02061 FLSTLLNVASNVVPTLICKITKKC Anti-Primarily active against Gram-positive bacteria: R. rhodochrous X15, activity value is MIC = 2.3 uM||Anti-B. licheniformis X39, activity value is MIC = 9 uM||Anti-E. faecalis 981, activity value is MIC = 75 uM||Anti-S. carnosus KHS, activity value is MIC = 19 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 19 uM||Anti-E.coli ATCC 25922, activity value is MIC = 150 uM||Anti-P.aeruginosa CGMCC 1.50, activity value is MIC > 150 uM||Anti-P.aeruginosa 11053, activity value is MIC > 150 uM||Anti-K.pneumoniae 08040724, activity value is MIC > 150 uM||Anti-P. faecalis X29, activity value is MIC = 4.5 uM||Anti-S. rubidaea X01, activity value is MIC = 9 uM||Anti-C.albicans ATCC 10231, activity value is MIC > 150 uM||Anti-Slime mold 090223, activity value is MIC = 9 uM||Anti-Rhodococcus rhodochrous X15, activity value is MIC = 2.3 uM||Anti-Bacillus licheniformis X39, activity value is MIC = 9 uM||Anti-Enterococcus faecalis 981, activity value is MIC = 75 uM||Anti-Staphylococcus carnosus KHS, activity value is MIC = 19 uM||Anti-Staphylococcus aureus, activity value is MIC = 19 uM||Anti-Escherichia coli, activity value is MIC = 150 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 4.5 uM||Anti-Serratia rubidaea X01, activity value is MIC = 9 uM||Anti-Gram+ & Gram-||Antifungal||Hemolytic Amolops chunganensis (Chungan torrent frog)|||skin secretions, Amolops chunganensis, China, Asia|||skin secretions, Amolops chunganensis, China, Asia N/A skin secretions, Amolops chunganensis, China, Asia||HC₅₀ = 5.5 uM。|||In Peptides 2012, among the antimicrobial peptides isolated from the skin secretions of the Chungan torrent frog (Amolops chunganensis), temporin-CG1, temporin-CG4, and temporin-CG5 all had LC₅₀ values greater than 150 µM for human red blood cells; temporin-CG2 and temporin-CG3 both had LC₅₀ values of 150 µM for human red blood cells; esculentin-2CG1, palustrin-2CG1, and brevinin-2CG1 all had LC₅₀ values of 75 µM for human red blood cells; brevinin-1CG1 had an LC₅₀ of 150 µM for human red blood cells, brevinin-1CG2, brevinin-1CG3, and brevinin-1CG5 all had LC₅₀ values of 19 µM for human red blood cells, and brevinin-1CG4 had an LC₅₀ of 37.5 µM for human red blood cells.|||highly hemolytic to human RBC (HC50 19 uM). "Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008.|||Peptides. 2012 Nov;38(1):41-53.|||22951323|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 24.|||Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Pub-Med." 24 FPDB02837 AP02062|||DRAMP01899|||AP02062 FLSTLLNVASKVVPTLFCKITKKC Anti-Primarily active against Gram-positive bacteria: R. rhodochrous X15, activity value is MIC = 2.3 uM||Anti-B. licheniformis X39, activity value is MIC = 9 uM||Anti-E. faecalis 981, activity value is MIC = 9 uM||Anti-S. carnosus KHS, activity value is MIC = 9 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 9 uM||Anti-E.coli ATCC 25922, activity value is MIC = 150 uM||Anti-P.aeruginosa CGMCC 1.50, activity value is MIC > 150 uM||Anti-P. aeruginosa 11053, activity value is MIC = 75 uM||Anti-K.pneumoniae 08040724, activity value is MIC > 150 uM||Anti-P. faecalis X29, activity value is MIC = 9 uM||Anti-S. rubidaea X01, activity value is MIC = 9 uM||Anti-C.albicans ATCC 10231, activity value is MIC = 150 uM||Anti-Slime mold 090223, activity value is MIC = 9 uM||Anti-Rhodococcus rhodochrous X15, activity value is MIC = 2.3 uM||Anti-Bacillus licheniformis X39, activity value is MIC = 9 uM||Anti-Enterococcus faecalis 981, activity value is MIC = 9 uM||Anti-Staphylococcus carnosus KHS, activity value is MIC = 9 uM||Anti-Staphylococcus aureus, activity value is MIC = 9 uM||Anti-Escherichia coli, activity value is MIC = 150 uM||Anti-Pseudomonas aeruginosa 11053, activity value is MIC = 75 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 9 uM||Anti-Serratia rubidaea X01, activity value is MIC = 9 uM||Anti-Candida albicans, activity value is MIC = 150 uM||Anti-Gram+ & Gram-||Antifungal||Hemolytic Amolops chunganensis (Chungan torrent frog)|||skin secretions, Amolops chunganensis, China, Asia|||skin secretions, Amolops chunganensis, China, Asia N/A skin secretions, Amolops chunganensis, China, Asia||HC₅₀ = 4.8 uM。|||In Peptides 2012, among the antimicrobial peptides isolated from the skin secretions of the Chungan torrent frog (Amolops chunganensis), temporin-CG1, temporin-CG4, and temporin-CG5 all had LC₅₀ values greater than 150 µM for human red blood cells; temporin-CG2 and temporin-CG3 both had LC₅₀ values of 150 µM for human red blood cells; esculentin-2CG1, palustrin-2CG1, and brevinin-2CG1 all had LC₅₀ values of 75 µM for human red blood cells; brevinin-1CG1 had an LC₅₀ of 150 µM for human red blood cells, brevinin-1CG2, brevinin-1CG3, and brevinin-1CG5 all had LC₅₀ values of 19 µM for human red blood cells, and brevinin-1CG4 had an LC₅₀ of 37.5 µM for human red blood cells.|||moderate hemolytic to human RBC (HC50 37.5 uM). "Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008.|||Peptides. 2012 Nov;38(1):41-53.|||22951323|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 25.|||Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Pub-Med." 24 FPDB02838 AP02063|||Brevinin-1CG5|||DRAMP01900|||AP02063|||AP02063 FLPMLAGLAANFLPKIVCKITKKC Anti-Primarily active against Gram-positive bacteria: R. rhodochrous X15, activity value is MIC = 0.6 uM||Anti-B. licheniformis X39, activity value is MIC = 2.3 uM||Anti-E. faecalis 981, activity value is MIC = 9 uM||Anti-S. carnosus KHS, activity value is MIC = 1.2 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 9 uM||Anti-E. coli ATCC 25922, activity value is MIC = 75 uM||Anti-P. aeruginosa CGMCC 1.50, activity value is MIC = 75 uM||Anti-P. aeruginosa 11053, activity value is MIC = 75 uM||Anti-K.pneumoniae 08040724, activity value is MIC = 150 uM||Anti-P. faecalis X29, activity value is MIC = 9 uM||Anti-S. rubidaea X01, activity value is MIC = 4.6 uM||Anti-C. albicans ATCC 10231, activity value is MIC = 37.5 uM||Anti-Slime mold 090223, activity value is MIC = 4.5 uM||Antibacterial||Anti-Rhodococcus rhodochrous X15, activity value is MIC = 0.6 uM||Anti-Bacillus licheniformis X39, activity value is MIC = 2.3 uM||Anti-Enterococcus faecalis 981, activity value is MIC = 9 uM||Anti-Staphylococcus carnosus KHS, activity value is MIC = 1.2 uM||Anti-Staphylococcus aureus, activity value is MIC = 9 uM||Anti-Escherichia coli, activity value is MIC = 75 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 75 uM||Anti-Pseudomonas aeruginosa 11053, activity value is MIC = 75 uM||Anti-Klebsiella pneumoniae 08040724, activity value is MIC = 150 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 9 uM||Anti-Serratia rubidaea X01, activity value is MIC = 4.6 uM||Anti-Candida albicans, activity value is MIC = 437.5 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic Amolops chunganensis [Chungan torrent frog]|||Amolops chunganensis (Chungan torrent frog)|||skin secretions, Amolops chunganensis, China, Asia|||skin secretions, Amolops chunganensis, China, Asia N/A skin secretions, Amolops chunganensis, China, Asia||HC₅₀ = 5.9 uM。|||Rhodococcus rhodochrous ( MIC = 0.6 uM )|||In Peptides 2012, among the antimicrobial peptides isolated from the skin secretions of the Chungan torrent frog (Amolops chunganensis), temporin-CG1, temporin-CG4, and temporin-CG5 all had LC₅₀ values greater than 150 µM for human red blood cells; temporin-CG2 and temporin-CG3 both had LC₅₀ values of 150 µM for human red blood cells; esculentin-2CG1, palustrin-2CG1, and brevinin-2CG1 all had LC₅₀ values of 75 µM for human red blood cells; brevinin-1CG1 had an LC₅₀ of 150 µM for human red blood cells, brevinin-1CG2, brevinin-1CG3, and brevinin-1CG5 all had LC₅₀ values of 19 µM for human red blood cells, and brevinin-1CG4 had an LC₅₀ of 37.5 µM for human red blood cells.|||highly hemolytic to human RBC (HC50 19 uM). "Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008.|||22951323|||Peptides. 2012 Nov;38(1):41-53.|||22951323|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 26.|||Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Pub-Med." 24 FPDB02839 AP02064 GILDKLKEFGISAARGVAQSLLNTTASCKLAKTC Anti-Primarily active against Gram-positive bacteria: R. rhodochrous X15, activity value is MIC = 2.3 uM||Anti-B. licheniformis X39, activity value is MIC = 75 uM||Anti-E. faecalis 981, activity value is MIC = 37.5 uM||Anti-S. carnosus KHS, activity value is MIC = 37.5 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 37.5 uM||Anti-E.coli ATCC 25922, activity value is MIC = 150 uM||Anti-P.aeruginosa CGMCC 1.50, activity value is MIC > 150 uM||Anti-P.aeruginosa 11053, activity value is MIC > 150 uM||Anti-K.pneumoniae 08040724, activity value is MIC > 150 uM||Anti-P. faecalis X29, activity value is MIC = 2.3 uM||Anti-S. rubidaea X01, activity value is MIC = 2.3 uM||Anti-C.albicans ATCC 10231, activity value is MIC > 150 uM||Anti-Slime mold 090223, activity value is MIC = 9 uM||Anti-Gram+ & Gram-||Antifungal||Hemolytic skin secretions, Amolops chunganensis, China, Asia N/A skin secretions, Amolops chunganensis, China, Asia||At a concentration of 100 μM, the hemolysis rate is < 10%.|||moderate hemolytic to human RBC (HC50 75 uM). "Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008.|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 27.|||Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Pub-Med." 34 FPDB02841 AP02068 YCERMMKRRSLTSPCKDVNTFIHGNKSNIKAICGANGSPYRENLRMSKSPFQVTTCKHTGGSPRPPCQYRASAGFRHVVIACENGLPVHFDESFFSL It is also established that this peptide is active against C. albicans and S. pneumoniae. Also angiogenic with RNase activity.||Anti-Gram+||Antifungal Mus musculus Combine Helix and Beta structure Mus musculus "Nat Immunol. 2003 Mar;4(3):269-73. doi: 10.1038/ni888. Epub 2003 Jan 27.|||Nat Immunol . 2003 Mar;4(3):269-73. doi: 10.1038/ni888. Epub 2003 Jan 27.|||Nat Immunol. 2003 Mar;4(3):269-73.Pub-Med. GenBank: NP_031473.11." 97 FPDB02852 AP02080|||CXCL10|||AP02080|||DRAMP03559 VPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP Anti-it killed 100% E. coli and 77% S. aureus. Active against E. coli, activity value is MIC = 3.6 ug/ml||Anti-L. monocytogenes, activity value is MIC = 7 ug/ml||Antibacterial ; Escherichia coli ATCC25922||Staphylococcus aureus ATCC29213||Antimicrobial||Antibacterial||Antiparasitic||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Chemotactic Homo sapiens [Human]|||Homo sapiens|||Homo sapiens (Human) Combine Helix and Beta structure Homo sapiens "J Immunol. 2001 Jul 15;167(2):623-7. doi: 10.4049/jimmunol.167.2.623.||this ref; Yang et al., 2003||Liu et al., 2014|||12949249|||J Immunol . 2001 Jul 15;167(2):623-7. doi: 10.4049/jimmunol.167.2.623.||this ref; Yang et al., 2003|||J Leukoc Biol. 2003 Sep;74(3):448-455.Structure. 2003 May;11(5):521-32.|||J Immunol. 2001 Jul 15;167(2):623-7. Pub-Med. GenBank:AAH10954.1." 77 FPDB02866 AP02098|||HsAp|||DRAMP18131|||HsAp|||AP02098|||AP02098 SGTSEKERESGRLLGVVKRLIVCFRSPFP Anti-K. oxytoca AB 2010143, activity value is MIC = 48||Anti-S. enterica AB 2010185, activity value is MIC = 23||Anti-G+ bacteria B. magaterium AB 90008, activity value is MIC = 11.8 um||Anti-S. aureus AB 94004, activity value is MIC = 23.6 uM||Anti-B. thuringiensis AB 93100, activity value is MIC = 46.5 uM||Anti-and fungi C. tropicalis AY 91009, activity value is MIC = 48.6 uM||Antibacterial||Antifungal||Anti-Staphylococcus aureus AB 94004, activity value is MIC = 23.6 uM||Anti-Bacillus magaterium AB 90008, activity value is MIC = 11.8 uM||Anti-Bacillus thuringiensis AB 93100, activity value is MIC = 46.5 uM||Anti-Salmonella enterica AB 2010185, activity value is MIC = 25 uM||Anti-E. coli DH5, activity value is MIC = 51.2 uM||Anti-E. coli JM109, activity value is MIC = 50.4 uM||Anti-Enterobacter cloacae subsp. cloacae AB 2010162, activity value is MIC = 47.9 uM||Anti-Klebsiella oxytoca AB 2010143, activity value is MIC = 50.5 uM||Anti-Candida tropicalis AY 91009, activity value is MIC = 48.6 uM||Anti-Gram+ & Gram-||Hemolytic Heterometrus spinifer [Asia giant forest scorpion]|||Heterometrus spinifer (Asia giant forest scorpion) (Malaysian blackscorpion)|||Heterometrus spinifer [Asia giant forest scorpion]|||venom, Heterometrus spinifer, Asia|||venom, Heterometrus spinifer, Asia N/A "venom, Heterometrus spinifer, Asia||At a concentration of 200 μM, the hemolysis rate is < 10%.|||Concentration <1 uM: No detectable hemolytic reaction (hemolysis rate 0%); Concentration = 1.6 uM: Causes about 35% red blood cell hemolysis; Concentration = 3.2 uM: Causes 95% red blood cell hemolysis; Concentration = 6.4 uM: Causes 100% red blood cell hemolysis (complete hemolysis).|||To determine the potential toxicity of HsAp in mammalian cells, we performed the hemolytic assay using human red blood cells. We found that the HsAp peptide is not able to induce detectable hemolytic reaction at the concentrations of less than 1.0 ␮M. How- ever, if the concentration of HsAp in the reaction mixture is up to 1.6 ␮M, it causes about 35% hemolysis of red blood cells. At a concentration of 3.2 ␮M or 6.4 ␮M, HsAp induces 95% and 100% hemolysis of the cells, respectively (Fig. 3). These results suggest that the HsAp peptide has relatively high hemolytic activity; this could be attributed to the presence of a highly hydrophilic residue Glu in the hydrophobic face of the HsAp molecule (Fig. 2D).|||1.6 uM, 35% hemolysis of human RBC; 3.2-6.4 uM, 95-100% hemolysis. Highly hemolytic." "Peptides. 2012 Dec;38(2):389-94. doi: 10.1016/j.peptides.2012.09.012. Epub 2012 Sep 21.|||23000095|||Peptides 38:389-394 (2012).||Ref.23000095|||23000095|||Peptides . 2012 Dec;38(2):389-94. doi: 10.1016/j.peptides.2012.09.012. Epub 2012 Sep 21.|||Peptides. 2012 Sep 21;38(2):389-394. Pub-Med." 29 FPDB02874 AP02112 GLMDTVKNAAKNLAGQLLDRLKCKITGC Anti-E. coli ATCC 25726, activity value is MIC = 20 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 80 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 20 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 40 uM||Anti-and C. albicans ATCC 90028, activity value is MIC = 40 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America N/A skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America||At a concentration of 100 μM, the hemolysis rate is < 10%.|||less hemo.lytic (human RBC HC50 135 uM). "Peptides. 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.|||Peptides . 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 23.|||Peptides. 2011 Apr;32(4):664-9. Pub-Med." 28 FPDB02875 AP02113 GLMDTIKGVAKNVAASLLEKLKCKVTGC Anti-E. coli ATCC 25726, activity value is MIC = 20 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 80 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 20 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 80 uM||Anti-and C. albicans ATCC 90028, activity value is MIC = 40 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America N/A skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America||At a concentration of 100 μM, the hemolysis rate is < 10%.|||less hemo.lytic (human RBC HC50 120 uM). "Peptides. 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.|||Peptides . 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 24.|||Peptides. 2011 Apr;32(4):664-9. Pub-Med." 28 FPDB02876 AP02114|||DRAMP01940|||AP02114 FLPIIAGVAAKVLPKLFCAITKKC Anti-E. coli ATCC 25726, activity value is MIC = 10 uM||Anti-E. coli, activity value is MIC = 10 uM||Anti-K. pneumoniae, activity value is MIC = 40 uM||Anti-P. aeruginosa, activity value is MIC = 20 uM||Anti-S. aureus, activity value is MIC = 2.5 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 40 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 20 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2.5 uM||Anti-and C. albicans ATCC 90028, activity value is MIC = 2.5 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic Rana chiricahuensis|||skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America|||skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America N/A skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America||HC₅₀ = 12.5 uM。|||[Ref.21262304] LC50=5 uM against human erythrocytes|||highly hemolytic (human RBC HC50 5 uM). "Peptides. 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.|||J Mol Evol. 2007 Nov;65(5):605-615.||Ref.2|||17938991||Ref.2|||Peptides . 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 25.|||Peptides. 2011 Apr;32(4):664-9. Pub-Med." 24 FPDB02877 AP02115|||DRAMP01941|||AP02115 FLPVIAGLAAKVLPKLFCAITKKC Anti-E. coli ATCC 25726, activity value is MIC = 10 uM||Anti-E. coli, activity value is MIC = 10 uM||Anti-K. pneumoniae, activity value is MIC = 40 uM||Anti-P. aeruginosa, activity value is MIC = 10 uM||Anti-S. aureus, activity value is MIC = 2.5 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 40 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 10 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2.5 uM||Anti-and C. albicans ATCC 90028, activity value is MIC = 2.5 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic Rana chiricahuensis|||skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America|||skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America N/A skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America||HC₅₀ = 10.8 uM。|||[Ref.21262304] LC50=5 uM against human erythrocytes|||highly hemolytic (human RBC HC50 5 uM). "Peptides. 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.|||J Mol Evol. 2007 Nov;65(5):605-615.||Ref.2|||17938991||Ref.2|||Peptides . 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 26.|||Peptides. 2011 Apr;32(4):664-9. Pub-Med." 24 FPDB02878 AP02116|||Brevinin-1CHc|||DRAMP01888|||Brevinin-1CHc|||AP02116|||AP02116 FFPTIAGLTKLFCAITKKC Anti-E. coli ATCC 25726, activity value is MIC = 80 uM||Antibacterial||Antifungal||Anti-E. coli, activity value is MIC = 80 uM||Anti-S. aureus, activity value is MIC = 20 uM||Antifungal ; Staphylococcus aureus||Candida albicans||Escherichia coli||Anti-S. aureus ATCC 25923, activity value is MIC = 20 uM||Anti-and C. albicans ATCC 90028, activity value is MIC = 20 uM||Anti-Gram+ & Gram-||candidacidal Lithobates chiricahuensis|||Rana chiricahuensis|||skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America|||skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America N/A skin secretions, Chiricahua leopard frog, Lithobates chiricahuensis, Arizona, USA, North America||HC₅₀ = 9.7 uM。 "Peptides. 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 22.|||21262304|||21262304|||Peptides . 2011 Apr;32(4):664-9. doi: 10.1016/j.peptides.2011.01.018. Epub 2011 Jan 27.|||Peptides. 2011 Apr;32(4):664-9. Pub-Med." 19 FPDB02882 AP02123|||Ceratoxin|||AP02123 NVTPATKPTPSKPGYCRVMDELILCPDPPLSKDLCKNDSDCPGAQKCCYRTCIMQCLPPIFRE Anti-recombinant peptide is active against S. aureus ATCC 25923, activity value is MIC = 1.5 ug/ml||Anti-E.coli ATCC 25922, activity value is MIC > 250 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC = 5.9 ug/ml||Anti-and C. albicans ATCC 20032, activity value is MIC = 5.9 ug/ml||Antibacterial||Anti-Gram+ & Gram-||Antifungal Ceratophrys calcarata [Colombian horned frog]|||Ceratophrys calcarata, Yunnan, China, Asia Bridge Ceratophrys calcarata, Yunnan, China, Asia|||ying cell membranes (Li et al., 2007a, 2007b). The hemolytic ability of ceratoxin was evaluated using human and rabbit red blood cells in our experiments. Ceratoxin showed little hemolytic activity. At the concentration of 50, 100, 200, and 400 ug/ml, it induced 1.1%, 1.3%, 2.1%, and 2.6% rabbit red blood cell hemolysis, respectively. For human blood red cells, the corresponding hemolytic rate was 0.7%, 1.1%, 1.7%, and 2.0%, respectively.|||human RBC: 2% hemolysis at 400 ug/ml (rabbit RBC 2.6% hemolysis), little hemo.lytic. "Gene. 2013 Feb 10;514(2):99-104. doi: 10.1016/j.gene.2012.11.007. Epub 2012 Nov 28.|||https://pubmed.ncbi.nlm.nih.gov/23200819|||Gene . 2013 Feb 10;514(2):99-104. doi: 10.1016/j.gene.2012.11.007. Epub 2012 Nov 28.|||Gene. 2012 Nov 27. pii: S0378-1119(12)01397-2. Pub-Med." 63 FPDB02885 AP02126|||Antimicrobial peptide CT3-NDBP-5.15 precursor|||UyCT3|||NDBP-5.7|||AP02126|||NDBP-5.7|||AP02126 ILSAIWSGIKSLF Anti-and E. coli, activity value is MIC = 6||Anti-C. tropicalis ATCC 750, activity value is MIC = 25 uM||Anti-C. neoformans H99 serotype A, activity value is MIC = 25 uM||Anti-and C. neoformans B3501 serotype D, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus ATCC 25953, activity value is MIC = 10 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 15 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 6 uM||Anti-M. luteus, activity value is MIC = 4 uM||Anti-E. coli, activity value is MIC = 8 uM||Anti-L. grayi, activity value is MIC = 8 uM||Anti-L. fleischmannii, activity value is MIC = 4 uM||Anti-L. monocytogenes, activity value is MIC = 4 uM||Anti-C. albicans SC5314, activity value is MIC = 25 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC > 400 uM||Anti-C. glabrata ATCC 90030, activity value is MIC > 400 uM||Anti-C. neoformans B3501 serotype D, activity value is MIC = 12.5 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibiofilm||Antibacterial Urodacus yaschenkoi|||Urodacus yaschenkoi [Inland robust scorpion]|||O. cayaporum|||venom, Urodacus yaschenkoi, Australia; also Opisthacanthus cayaporum|||O. cayaporum|||venom, Urodacus yaschenkoi, Australia; also Opisthacanthus cayaporum N/A "venom, Urodacus yaschenkoi, Australia; also Opisthacanthus cayaporum||HC₅₀ = 18 uM。|||Pig erythrocyte (50% hemolysis at 58.15 uM)|||The hemolytic values of the four synthetic peptides explicitly mentioned in the document (UyCT1, UyCT2, UyCT3, UyCT5) are as follows: 1. Hemolysis rate of each peptide at minimum inhibitory concentration (MIC) (percentage) UyCT1: 26% against Staphylococcus aureus (ATCC 25953), 17% against Escherichia coli (ATCC 25922), and 17% against Pseudomonas aeruginosa (ATCC 9027). UyCT2: No activity against Staphylococcus aureus (ATCC 25953) (no antibacterial activity at the highest test concentration of 100 uM, no corresponding hemolysis rate data); 7% against Escherichia coli (ATCC 25922), 7% against Pseudomonas aeruginosa (ATCC 9027). UyCT3: 20% against Staphylococcus aureus (ATCC 25953), 35% against E. coli (ATCC 25922), and 5% against Pseudomonas aeruginosa (ATCC 9027). UyCT5: 0% against Staphylococcus aureus (ATCC 25953), 37% against E. coli (ATCC 25922), and 0% against Pseudomonas aeruginosa (ATCC 9027). 2. Hemolysis rate of each peptide at 50 uM concentration (percentage) UyCT1：81% UyCT2：7% UyCT3：95% UyCT5：93% Additionally, the document mentions: UyCT2 has the lowest hemolytic activity among the four peptides, with a hemolytic rate of only 7% even at 50 μM. UyCT5 showed no hemolytic activity (0%) at MIC concentrations against Staphylococcus aureus and Pseudomonas aeruginosa, and showed 37% mild hemolysis only at MIC concentrations (15 uM) against E. coli. C-terminal amide formation of peptides is crucial for their antibacterial activity, but no direct impact of this modification on hemolysis is mentioned.|||Exhibits hemolysis against human erythrocytes|||the hemolytic activity of each peptide was assayed against human erythrocytes as a model of their cytotoxicity against mammalian cells. Peptide UyCT2 has a low percentage of hemolysis even at 50000 uM (6.8%), therefore, at MICvalues the percentage ofhemolysis is verylow (Table 4). Peptide UyCT1exhibits17–25%ofhemolysis at its respective MIC is shown in Table 4. UyCT5 does not show hemolysis at lower concentrations but for MIC at 15000 uMthe percentage of hemolysis is about 37%, making this peptide mildly hemolytic." "Toxicon. 2013 Mar 1:63:44-54. doi: 10.1016/j.toxicon.2012.11.017. Epub 2012 Nov 23.||Guilhelmelli F et al., 2016|||23182832|||28067810, 23182833||Refer PubMed ID: 23182832|||27917162|||Toxicon. 2013 Mar 1;63:44-54. Pub-Med.|||27917162|||Toxicon . 2013 Mar 1:63:44-54. doi: 10.1016/j.toxicon.2012.11.017. Epub 2012 Nov 23.||Guilhelmelli F et al., 2016" 13 FPDB02887 AP02128|||Haxy_Col1|||AP02128 SLQPGAPNFPIPGQEKQEGWKFDPSLTRGEDGNTLGSINIHHTGPNHEVGANWDKVIRGPGKAKPTYSIHGSWRW Anti-Gram-||Antifungal||Antibacterial||Antifungal ; Micrococcus luteus||Escherichia coli D31||Metarhizium anisopliae strain 43 Harmonia axyridis [Multicolored Asian lady beetle]|||ladybird beetle, Harmonia axyridis N/A ladybird beetle, Harmonia axyridis "Proc Biol Sci. 2013 Jan 7;280(1750):20122113. doi: 10.1098/rspb.2012.2113.|||23173204|||Proc Biol Sci . 2013 Jan 7;280(1750):20122113. doi: 10.1098/rspb.2012.2113.|||Proc Biol Sci. 2013 Jan 7;280(1750):20122113.Pub-Med." 75 FPDB02888 AP02129|||Haxy_Col6|||AP02129 SLQPGAPKLPYAWSRKQEGWKFDPSLTRGEDGNTLGSINIHHTGRNHEVGANWNKVIRGPGKAKPTYSIHGSWRW Anti-Gram-||Antifungal||Antibacterial||Antifungal ; Micrococcus luteus||Escherichia coli D31||Metarhizium anisopliae strain 43 Harmonia axyridis [Multicolored Asian lady beetle]|||ladybird beetle, Harmonia axyridis N/A ladybird beetle, Harmonia axyridis "Proc Biol Sci. 2013 Jan 7;280(1750):20122113. doi: 10.1098/rspb.2012.2113.|||23173204|||Proc Biol Sci . 2013 Jan 7;280(1750):20122113. doi: 10.1098/rspb.2012.2113.|||Proc Biol Sci. 2013 Jan 7;280(1750):20122113.Pub-Med." 75 FPDB02889 AP02143|||Plantaricin-149|||DRAMP00249|||AP02143|||DRAMP00249|||AP02143 YSLQMGATAIKQVKKLFKKKGG Pln149a was active against one strain of S. aureus and four strains of Listeria genus at pH 5.5 and 7.4 and||like its natural form||inhibited L. plantarum ATCC 8014.||Antibacterial||Antimicrobial||Antifungal||Anti-Gram+ Lactobacillus plantarum NRIC 149|||Lactobacillus plantarum NRIC 149 (Gram-positive bacteria)|||Lactiplantibacillus plantarum; (old) Lactobacillus plantarum NRIC 149; isolated from pineapple:microbiota (peptide conjugates:fatty acid)|||Lactobacillus plantarum NRIC 149 (Gram-positive bacteria)|||Lactiplantibacillus plantarum; (old) Lactobacillus plantarum NRIC 149; isolated from pineapple:microbiota (peptide conjugates:fatty acid) Helix||Alpha helix Lactiplantibacillus plantarum; (old) Lactobacillus plantarum NRIC 149; isolated from pineapple||HC₅₀ ≈ 20 uM。|||The hemolytic value of Pln149a is: within the concentration range of 25–400 ug/ml, it only shows 16% low hemolytic activity. J. Fermentation Bioeng. 1994;77(3):277-282.|||17266050|||J. Fermentation Bioeng. 1994;77(3):277-282. 22 FPDB02896 AP02150|||DRAMP02946 YEALVTSILGKLTGLWHNDSVDFMGHICYFRRRPKIRRFKLYHEGKFWCPGWAPFEGRCKYCVVF Anti-Recombinant fusion protein containing this peptide is active against bacteria Gram- V. alginolyticus L59, activity value is MIC = 0.5||Anti-P. aeruginosa P25, activity value is MIC = 1.01||Anti-M-luteus M2, activity value is MIC > 64.3 uM||Anti-S-aureus S7, activity value is MIC > 64.3 uM||Anti-and fungus P. pastoris GS115, activity value is MIC = 8.04||Antimicrobial||Antibacterial||Anti-Gram-||Antifungal haemocytes, swimming crab Portunus trituberculatus|||Tachypleus tridentatus (Japanese horseshoe crab) N/A haemocytes, swimming crab Portunus trituberculatus "Fish Shellfish Immunol. 2013 Feb;34(2):652-9. doi: 10.1016/j.fsi.2012.12.002. Epub 2012 Dec 20.||Liu Y et al., 2012|||Fish Shellfish Immunol . 2011 Feb;30(2):583-91. doi: 10.1016/j.fsi.2010.12.005. Epub 2010 Dec 17.||Liu Y et al., 2012|||J Biol Chem. 1999 Sep 10;274(37):26172-26178.J Biol Chem. 1999 Sep 10;274(37):26172-26178.|||Fish Shellfish Immunol. 2011 Feb;30(2):583-91.Pub-Med." 65 FPDB02897 AP02152|||DRAMP02947 YEALVTSILGKLTGLWHNDSVDFMGHICYFRRRPKIRRFKLYHEGKFWCPGWAPFEGRSRTKSRSGSSREATKDFVRKALQNGLVTQQDASLWLN Anti-Recombinant fusion protein containing this peptide is active against bacteria Gram- V. alginolyticus L59, activity value is MIC = 0.29||Anti-P. aeruginosa P25, activity value is MIC = 0.29||Anti-M. luteus M2, activity value is MIC = 9.26||Anti-S. aureus S7, activity value is MIC = 37.04||Anti-and fungus P. pastoris GS115, activity value is MIC = 4.63||Antimicrobial||Antibacterial||Anti-Gram+ & Gram-||Antifungal haemocytes, swimming crab Portunus trituberculatus|||Tachypleus tridentatus (Japanese horseshoe crab) N/A haemocytes, swimming crab Portunus trituberculatus "Fish Shellfish Immunol.2011 Feb;30(2):583-91. doi: 10.1016/j.fsi.2010.12.005. Epub 2010 Dec 17.||Liu Y et al., 2012|||Fish Shellfish Immunol . 2011 Feb;30(2):583-91. doi: 10.1016/j.fsi.2010.12.005. Epub 2010 Dec 18.||Liu Y et al., 2012|||J Biol Chem. 1999 Sep 10;274(37):26172-26178.J Biol Chem. 1999 Sep 10;274(37):26172-26178.|||Fish Shellfish Immunol. 2011 Feb;30(2):583-91.Pub-Med." 95 FPDB02898 AP02153|||PtALF4|||AP02153 GGWLDIVKAIVVPAARETIKTQEITLLDHYCTLSRSPYIKSLELHYRAEVTCPGWTIIRGRGSNHRNPTNSGKDALKDFMTQAVAAGLVTKEEAAPWLN Anti-Recombinant fusion protein containing this peptide is active against bacteria Gram- V. alginolyticus L59, activity value is MIC = 1.66||Anti-P. aeruginosa P25, activity value is MIC = 26.57||Anti-M.luteus M2, activity value is MIC > 106.28 uM||Anti-S.aureus S7, activity value is MIC > 106.28 uM||Anti-and fungus P. pastoris GS115, activity value is MIC = 53.14||Antibacterial||Anti-Gram-||Antifungal Portunus trituberculatus [Swimming crab]|||eyestalk; swimming crab Portunus trituberculatus N/A eyestalk; swimming crab Portunus trituberculatus "Fish Shellfish Immunol.2011 Feb;30(2):583-91. doi: 10.1016/j.fsi.2010.12.005. Epub 2010 Dec 17.||Liu Y et al., 2012|||22333564|||Fish Shellfish Immunol . 2011 Feb;30(2):583-91. doi: 10.1016/j.fsi.2010.12.005. Epub 2010 Dec 19.||Liu Y et al., 2012|||Fish Shellfish Immunol. 2011 Jul;31(1):29-42.Pub-Med." 99 FPDB02902 AP02160|||Mytimacin-AF|||AP02160 TDTNVIGECFDEWSRCHRQTRWWTKILFQSCENRCKCKVQLMGNCIKVPFKCFLWKQKRFMCECYGPISGTKPWYCGWEL Anti-E. coli ATCC 25922, activity value is MIC = 7.5 ug/ml||Anti-S. aureus ATCC 25923, activity value is MIC = 1.9 ug/ml||Anti-B. pyocyaneus CMCCB 10104, activity value is MIC = 3.75 ug/ml||Anti-B. megatherium, activity value is MIC = 15 ug/ml||Anti-B. dysenteriae, activity value is MIC = 3.75 ug/ml||Anti-K. pneumoniae, activity value is MIC = 30 ug/ml||Anti-and C. albicans ATCC 20032, activity value is MIC = 7.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 1.9 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Achatina fulica [Giant African snail]|||giant African land snaill, Achatina fulica N/A giant African land snaill, Achatina fulica|||Some AMPs were found to exert hemolytic activities [10,11]. Human red blood cells were used to evaluate the peptide’s hemolytic capability. The result showed little hemolytic activity was exerted by mytimacin-AF. At the concentration of 5, 10, 20, 40, 80, 160, and 320 ␮g/ml, respectively, it induced 1.1, 1.3, 1.7, 2.4, 2.3, 3.2, and 3.9% human red blood cell hemolysis, respectively. "Peptides. 2012 Oct 24;39C:1-5. Pub-Med.|||23103587|||Peptides . 2013 Jan:39:1-5. doi: 10.1016/j.peptides.2012.09.001. Epub 2012 Oct 24.|||Peptides. 2012 Oct 24;39C:1-5. Pub-Med." 80 FPDB02912 AP02172|||Css54|||AP02172|||DRAMP18488 FFGSLLSLGSKLLPSVFKLFQRKKE Anti-E. coli and S. aureus, activity value is MIC = 12.5 ug/ml||activity value is MFC = 4 uM||Anti-Escherichia coli, activity value is MIC = 12.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic||Antibiofilm||Anti-##Gram-negative bacterium: Escherichia coli, activity value is MIC = 12.5 ug/ml Centruroides suffusus suffusus [Mexican scorpion]|||venoms, Centruroides suffusus suffusus, Mexico, North America|||Centruroides suffusus (Mexican scorpion) Helix "venoms, Centruroides suffusus suffusus, Mexico||25 uM/ml 83%；80 ug/ml 80%~100%|||The document explicitly mentions the hemolytic values of three antimicrobial peptides (La47, Css54, Pin2) against human red blood cells, which were measured by incubating the peptides with a 10% (v/v) human red blood cell suspension at room temperature for 1 hour. Deionized water was used as the 100% hemolysis positive control, and PBS served as the blank control. The specific data are as follows: 1. Hemolysis rate at key concentrations (percentage) At 25 µM concentration: Pin2: Hemolysis rate was 100%, complete hemolysis. Css54: Hemolysis rate was 83%, relatively strong hemolytic activity. La47: Hemolysis rate was only 2%, very weak hemolytic activity. At 80 µg/ml concentration: La47: Still showed no significant hemolysis, almost no toxicity to human red blood cells. Pin2 and Css54: At this concentration, they caused 80%~100% hemolysis of human red blood cells, significantly higher hemolytic activity than La47. 2. Supplementary conclusions Hemolytic activity is positively correlated with antimicrobial activity: Pin2 and Css54 have stronger antimicrobial activity (for example, minimum inhibitory concentrations (MIC) against Staphylococcus aureus are 10.4 µg/ml and 12.5 µg/ml, respectively), and their hemolytic activity is also higher; whereas La47 has weaker antimicrobial activity (MIC against Staphylococcus aureus is 84 µg/ml) and the lowest hemolytic activity. Safety differences: Due to its extremely low hemolytic activity, La47 may have higher safety for local topical treatment of epithelial tissue bacterial infections; although Pin2 and Css54 have strong antimicrobial abilities, their relatively high hemolytic activity limits their applicability to eukaryotic cells (such as red blood cells).|||[Ref.23093034]30% hemolytic activity at 9 uM, 67% hemolytic activity at 17 uM against human erythrocytes|||2.65% hemolysis at 4 uM; 80% hemolysis at 30 uM, HC50=15 uM, hemolytic at high concentrations." "J Antibiot (Tokyo). 2013 Jan;66(1):3-10.Pub-Med.||Park et al., 2024|||23093034|||J Antibiot (Tokyo). 2013 Jan;66(1):3-10.Pub-Med.|||J Antibiot (Tokyo) . 2013 Jan;66(1):3-10. doi: 10.1038/ja.2012.87. Epub 2012 Oct 24.||Park et al., 2024|||Ref.23093034|||J Antibiot (Tokyo). 2013 Jan;66(1):3-10.||Ref.23093034" 25 FPDB02914 AP02174|||Lantibiotic streptin, Senegalin|||DRAMP04679|||Lantibiotic streptin, Senegalin|||AP02174|||AP02174 FLPFLIPALTSLISSL Anti-S. aureus, activity value is MIC = 50 uM||Anti-Staphylococcus aureus, activity value is MIC = 50 uM||Anti-Candida albicans, activity value is MIC = 150 uM||Anti-S. aureus NCTC 10788, activity value is MIC = 50 uM||Antibacterial||Antifungal||Anti-Gram+||candidacidal Kassina senegalensis|||Kassina senegalensis (Senegal running frog)|||Kassina senegalensis [Senegal running frog]|||skin, Kassina senegalensis , Africa|||skin, Kassina senegalensis , Africa N/A skin, Kassina senegalensis , Africa||At a concentration of 150 uM, Senegalin showed no significant hemolytic effect on equine red blood cells, with no obvious hemolysis observed. "Amino Acids. 2013 May;44(5):1347-55. Pub-Med.|||23430307|||Amino Acids. 2013 May;44(5):1347-1355.|||23430307|||Amino Acids . 2013 May;44(5):1347-55. doi: 10.1007/s00726-013-1470-8. Epub 2013 Feb 22.|||Amino Acids. 2013 May;44(5):1347-55. Pub-Med." 16 FPDB02915 AP02175|||CATH_BRALE|||AP02175 RRSKARGGSRGSKMGRKDSKGGSRGRPGSGSRPGGGSSIAGASRGDRGGTRNA Anti-two Gram-negative fish pathogens A. salmonicida and A. hydrophila, activity value is MIC = 9.4 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 4.7 uM||Anti-E. coli ATCC 25922, activity value is MIC = 2.34 uM||Anti-E. coli IS 1342, activity value is MIC = 4.7 uM||Anti-A. baumannii, activity value is MIC = 4.7 uM||Anti-P. mirabilis, activity value is MIC = 18 uM||Anti-A. sobria, activity value is MIC = 18.8 uM||Anti-positive S. aureus ATCC 2592, activity value is MIC = 11||Anti-E. faecium, activity value is MIC = 11.4 uM||Anti-C. albicans ATCC 2002, activity value is MIC = 2.3 uM||Anti-and C. glabrata IS 0902, activity value is MIC = 9.4 uM||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 22.75 uM||Anti-S. aureus, activity value is MIC = 11.38 uM||Anti-S. aureus, activity value is MIC = 45.5 uM||Anti-Enterococcus faecium, activity value is MIC = 11.38 uM||Anti-Nocardia asteroides, activity value is MIC = 22.75 uM||Anti-Aeromonas sobria, activity value is MIC = 18.76 uM||Anti-Aeromonas salmonicida, activity value is MIC = 9.38 uM||Anti-Proteus mirabilis, activity value is MIC = 18.75 uM||Anti-Acinetobacter baumannii, activity value is MIC = 4.69 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 18.76 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.34 uM||Anti-Escherichia coli, activity value is MIC = 4.69 uM||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 4.69 uM||Anti-P. aeruginosa, activity value is MIC = 1.17 uM||Anti-Aeromonas hydrophila, activity value is MIC = 9.38 uM||Anti-Slime mould, activity value is MIC = 22.75 uM||Anti-Slime mould, activity value is MIC = 11.38 uM||Anti-Candida glabrata, activity value is MIC = 9.38 uM||Anti-Candida albicans ATCC 2002, activity value is MIC = 2.34 uM||Anti-Aeromonas sobria, activity value is MIC = 3.6 uM||Anti-Aeromonas hydrophila, activity value is MIC = 1.8 uM||Anti-Aeromonas veronii, activity value is MIC = 1.8 uM||Anti-Vibrio harveyi, activity value is MIC = 0.9 uM||Anti-Vibrio parahaemotyticus, activity value is MIC = 0.45 uM||Anti-Vibrio anguillarum, activity value is MIC = 1.8 uM||Anti-Vibrio vulnificus, activity value is MIC = 0.45 uM||Anti-Vibrio splendidus 1, activity value is MIC = 3.6 uM||Anti-Vibrio splendidus 2, activity value is MIC = 0.9 uM||Anti-Vibrio cholerae, activity value is MIC = 0.9 uM||Anti-Staphylococcus aureus 1, activity value is MIC = 1.8 uM||Anti-Staphylococcus aureus 2, activity value is MIC = 3.6 uM||Anti-Streptococcus agalactiae, activity value is MIC = 1.8 uM||Anti-Nocardia asteroides, activity value is MIC = 0.9 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal Brachymystax lenok [Lenok trout]|||Brachymystax lenok [ Salmonid fish]|||gill, salmonoid, Brachymystax lenok N/A gill, salmonoid, Brachymystax lenok||At a concentration of 100 uM (over 10 times the minimal inhibitory concentration, MIC), CATH_BRALE induced only 6.8% hemolysis of erythrocytes, indicating negligible hemolytic activity. "Fish Shellfish Immunol. 2013 Jan;34(1):1-7. Pub-Med.|||23390641|||31202967|||Fish Shellfish Immunol . 2013 Jan;34(1):1-7. doi: 10.1016/j.fsi.2012.07.004.|||Fish Shellfish Immunol. 2013 Jan;34(1):1-7. Pub-Med." 53 FPDB02917 AP02177 LLGMIPLAISAISSLSKL Anti-S. aureus, activity value is MIC = 32 ug/ml||Anti-Gram+||Antifungal||candidacidal||Hemolytic skin secretion, red-eyed leaf frog, Agalychnis callidryas, Central America N/A skin secretion, red-eyed leaf frog, Agalychnis callidryas, Central America||At the MIC for C. albicans (32–128 ug/ml), medusin-PD induced only 6.9% hemolysis|||Hemolytic 60% at 128 ug/ml (70 uM), moderate hemolytic. "Biochimie. 2013 Jun;95(6):1288-96. Pub-Med.|||Biochimie . 2013 Jun;95(6):1288-96. doi: 10.1016/j.biochi.2013.02.005. Epub 2013 Feb 14." 18 FPDB02918 AP02179|||CAMPSQ3823|||Panurgine 1|||AP02179|||DRAMP20781|||AP02179 LNWGAILKHIIK Anti-S. aureus, activity value is MIC = 10.6 uM||Anti-antifungal activity (C. albicans, activity value is MIC = 7.3 uM||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 3.7 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 51.7 uM||Anti-## Gram-positive bacteria: Micrococcus luteus, activity value is MIC = 1.5 uM||Anti-Bacillus subtilis, activity value is MIC = 1.3 uM||Anti-Staphylococcus aureus, activity value is MIC = 10.6 uM||Anti-## Yeast: Candida albicans, activity value is MIC = 7.3 uM||Anti-Gram+ & Gram-||candidacidal Synthetic construct|||Panurgus calcaratus|||Panurgus calcaratus|||venom, communal bee, Panurgus calcaratus, Europe|||Panurgus calcaratus(communal bee)|||venom, communal bee, Panurgus calcaratus, Europe N/A venom, communal bee, Panurgus calcaratus||PNG-1 showed moderate hemolytic activity (LC₅₀ = 119 uM), with activity varying among analogs.PNG-1/19 (Leu-substituted) and PNG-1/20 (Norleu-substituted) had reduced LC₅₀ values (63–40 uM), indicating increased hemolysis.PNG-1/21 (Aca-substituted) had LC₅₀ = 43 uM, balancing antimicrobial potency and hemolysis.Analogs with decreased hydrophobicity (e.g., PNG-1/15, PNG-1/16) showed no hemolytic activity (LC₅₀ > 200 uM).|||[Ref.23483218] LC50=119 uM against rat red blood cells|||Hemolytic HC50 119 uM. "Amino Acids. 2013 Jul;45(1):143-57. Pub-Med.|||23483218|||23483218|||Amino Acids . 2013 Jul;45(1):143-57. doi: 10.1007/s00726-013-1482-4. Epub 2013 Mar 13.|||Amino Acids. 2013 Jul;45(1):143-57.||Ref.23483218|||Amino Acids. 2013 Jul;45(1):143-57. Pub-Med." 12 FPDB02919 AP02180 LDVKKIICVACKIKPNPACKKICPK Anti-Gram+ & Gram-||Antifungal||candidacidal venom, communal bee, Panurgus calcaratus, Europe Bridge venom, communal bee, Panurgus calcaratus||It exhibited no significant hemolysis at concentrations up to their MICs, with LC₅₀ > 200 uM.Its linear analogs PNG-K/1 was also non-hemolytic. "Amino Acids. 2013 Jul;45(1):143-57. Pub-Med.|||Amino Acids . 2013 Jul;45(1):143-57. doi: 10.1007/s00726-013-1482-4. Epub 2013 Mar 14." 25 FPDB02920 AP02181 LDVKKIICVACKIRPNPACKKICPK Anti-Gram+ & Gram-||Antifungal||candidacidal venom, communal bee, Panurgus calcaratus, Europe Bridge venom, communal bee, Panurgus calcaratus||It exhibited no significant hemolysis at concentrations up to their MICs, with LC₅₀ > 200 uM.Its linear analogs PNG-R/1 was also non-hemolytic. "Amino Acids. 2013 Jul;45(1):143-57. Pub-Med.|||Amino Acids . 2013 Jul;45(1):143-57. doi: 10.1007/s00726-013-1482-4. Epub 2013 Mar 15." 25 FPDB02925 AP02189|||DRAMP18218|||AP02189|||DRAMP18218 TVVTNA Anti-M. luteus IFO 3333, activity value is MIC < 0.78 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC = 3.12 ug/ml||Anti-and P. thomii, activity value is MIC = 1.56||Anti-S.cerevisiae HUT 7099, activity value is MIC > 100 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Antifungal Bacillus polymyxa KT-8 N/A Bacillus polymyxa KT-8 "J Antibiot (Tokyo). 1996 Feb;49(2):129-35.Pub-Med.|||J Antibiot (Tokyo). 1996 Feb;49(2):129-35.|||J Antibiot (Tokyo) . 1996 Feb;49(2):129-35. doi: 10.7164/antibiotics.49.129.|||J Antibiot (Tokyo). 1996 Feb;49(2):129-35.PLoS One. 2012;7(11):e50003." 6 FPDB02926 AP02190|||DRAMP18219|||AP02190|||DRAMP18219 TVVTQA Anti-B. subtilis ATCC 6633, activity value is MIC = 1.56||Anti-P. thomii, activity value is MIC = 1.56||Anti-S. cerevisiae HUT 7099, activity value is MIC = 12.5 ug/ml||Anti-S.marcescens IFO 3736, activity value is MIC > 100 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Antifungal Bacillus polymyxa KT-8 N/A Bacillus polymyxa KT-8 "J Antibiot (Tokyo). 1997 Mar;50(3):220-8.Pub-Med.|||J Antibiot (Tokyo). 1997 Mar;50(3):220-8.|||J Antibiot (Tokyo) . 1996 Feb;49(2):129-35. doi: 10.7164/antibiotics.49.130.|||J Antibiot (Tokyo). 1997 Mar;50(3):220-8.PLoS One. 2012;7(11):e50003." 6 FPDB02927 AP02191|||DRAMP18220|||AP02191|||DRAMP18220 TVYTNA Anti-B. subtilis ATCC 6633, activity value is MIC < 0.78||Anti-and P. thomii, activity value is MIC = 1.56||Anti-S.cerevisiae HUT 7099, activity value is MIC > 100 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Antifungal Bacillus polymyxa KT-8 N/A Bacillus polymyxa KT-8 "J Antibiot (Tokyo). 1997 Mar;50(3):220-8.Pub-Med.|||J Antibiot (Tokyo). 1997 Mar;50(3):220-8.|||J Antibiot (Tokyo) . 1996 Feb;49(2):129-35. doi: 10.7164/antibiotics.49.131.|||J Antibiot (Tokyo). 1997 Mar;50(3):220-8.PLoS One. 2012;7(11):e50003." 6 FPDB02928 AP02192|||DRAMP18221|||AP02192|||DRAMP18221 TVYTQA Anti-B. subtilis ATCC 6633, activity value is MIC < 0.78||Anti-and P. thomii, activity value is MIC = 1.56||Anti-S.cerevisiae HUT 7099, activity value is MIC > 100 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Antifungal Bacillus polymyxa KT-8 N/A Bacillus polymyxa KT-8 "J Antibiot (Tokyo). 1997 Mar;50(3):220-8.Pub-Med.|||J Antibiot (Tokyo). 1997 Mar;50(3):220-8.|||J Antibiot (Tokyo) . 1996 Feb;49(2):129-35. doi: 10.7164/antibiotics.49.132.|||J Antibiot (Tokyo). 1997 Mar;50(3):220-8.PLoS One. 2012;7(11):e50003." 6 FPDB02933 AP02197|||DRAMP04673|||AP02197|||DRAMP04673 PAAAAQAVAGLAPVAAEQ Mainly active against Gram-positive bacteria and fungi.||Antimicrobial||Antibacterial||Antifungal||Antiparasitic||No MICs found in DRAMP database||Anti-Gram+||Hemolytic Trichoderma viride Helix||Alpha helix Trichoderma viride|||No hemolysis information or data found in the reference(s) presented in this entry "Experientia, 1967; 23: 85-86. PubMed|||Experientia, 1967; 23: 85-86.|||Experientia . 1967 Feb 15;23(2):85-6. doi: 10.1007/BF02135929.|||Experientia, 1967; 23: 85-86.##Nature. 1982 Nov 25;300(5890):325-330." 18 FPDB02934 AP02198 KAYSMPRCKGGFRAVMCWL Anti-Gram+ & Gram-||Antifungal||candidacidal skin, Rana shuchinae, China, Asia N/A skin, Rana shuchinae, China, Asia||At concentrations as high as 200 ug/ml, the hemolysis rate of shuchins 3 on rabbit red blood cells is 1.3%, and on human red blood cells is 1.7%. "Gene. 2013 Jun 1;521(2):234-7. Pub-Med.|||Gene . 2013 Jun 1;521(2):234-7. doi: 10.1016/j.gene.2013.03.054. Epub 2013 Apr 2." 19 FPDB02935 AP02199 KAYSTPRCKGLFRALMCWL Anti-Gram+ & Gram-||Antifungal||candidacidal skin, Rana shuchinae, China, Asia N/A skin, Rana shuchinae, China, Asia||At concentrations up to 200 ug/ml, the hemolysis rate of shuchins 4 on rabbit red blood cells is 1.2%, and on human red blood cells is 2.5%.|||little hemolysis at 200 ug/ml. "Gene. 2013 Jun 1;521(2):234-7. Pub-Med.|||Gene . 2013 Jun 1;521(2):234-7. doi: 10.1016/j.gene.2013.03.054. Epub 2013 Apr 3." 19 FPDB02936 AP02200 KAYSMPRCKYLFRAVLCWL Anti-Gram+ & Gram-||Antifungal||candidacidal skin, Rana shuchinae, China, Asia N/A skin, Rana shuchinae, China, Asia||At concentrations as high as 200 ug/ml, the hemolysis rate of shuchins 3 on rabbit red blood cells is 1.6%, and on human red blood cells is 1.5%.|||little hemolysis at 200 ug/ml. "Gene. 2013 Jun 1;521(2):234-7. Pub-Med.|||Gene . 2013 Jun 1;521(2):234-7. doi: 10.1016/j.gene.2013.03.054. Epub 2013 Apr 4." 19 FPDB02945 AP02212|||Sarcotoxin Pd|||AP02212 GWLKKIGKKIERVGQHTRGLGIAQIAANVAATAR Anti-A. umigates, activity value is MIC = 6||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Spermicidal Paederus dermatitis N/A Paederus dermatitis||In the concentration range of 5–100 ug/ml, sarcotoxin Pd exhibits low hemolytic activity.At a concentration of 100 ug/ml, it only induces approximately 10% hemolysis of human red blood cells.Within its minimum inhibitory concentration (MIC, ≤30 ug/ml) range, the hemolysis rate is extremely low. Int J Pept Res Ther DOI 10.1007/s10989-012-9320-1. Publisher.||Zare-Zardini H et al., 2015|||Reference: Memarpoor-Yazdi M, Zare-Zardini H, Asoodeh A (2013) A Novel Antimicrobial Peptide Derived from the Insect Paederus dermatitis. Int J Pept Res Ther DOI 10.1007/s10989-012-9320-1|||Int J Pept Res Ther DOI 10.1007/s10989-012-9320-1. Publisher.||Zare-Zardini H et al., 2015|||Int J Pept Res Ther DOI 10.1007/s10989-012-9320-1. Publisher. 34 FPDB02950 AP02222 FIPLVSGLFSRLL Anti-E. coli, activity value is MIC = 12.5 ug/ml||Anti-S. aureus, activity value is MIC = 6.25 ug/ml||Anti-and C. albicans, activity value is MIC = 12.5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Dark-spotted frogs, Pelophylax nigromaculatus, Kunming, Yunnan, China, Asia N/A Dark-spotted frogs, Pelophylax nigromaculatus, Kunming, Yunnan, China, Asia||No hemolytic activity was observed at concentrations as high as 200 ug/ml. "Biosci Biotechnol Biochem. 2013 May 23;77(5):1075-9. Pub-Med.|||Biosci Biotechnol Biochem . 2013;77(5):1075-9. doi: 10.1271/bbb.130044. Epub 2013 May 7." 13 FPDB02954 AP02226 FCHLCEDLIKDGKEAGDVALDVWLDEEIGSRCKDFGVLASECFKELKVAEHDIWEAIDQEIPEDKTCKEAKLC Active against Gram-positive bacteria||yeast cells and amoebae by permeabilizing their membranes. SPP-12 binds to phospholipid membranes and forms pores in a pH-dependent manner characteristic of caenopores.||Anti-Gram+||Antifungal Caenorhabditis elegans N/A Caenorhabditis elegans "Biochem J. 2012 Jul 15;445(2):205-12. Pub-Med.|||Biochem J . 2012 Jul 15;445(2):205-12. doi: 10.1042/BJ20112102." 73 FPDB02957 AP02230|||Non-histone chromosomal protein HMG-17, HMGN2|||AP02230 PKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKAPAKKGEKVPKGKKGKADAGKEGNNPAENGDAKTDQAQKAEGAGDAK Active against E. coli ML-35p||P. aeruginosa||and C. albicans ATCC 10231.||Anti-Escherichia coli ML-35p, activity value is MIC = 12.5 ug/ml||Anti-Escherichia coli ML-35p, activity value is MBC = 25 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 50 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 100 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MBC = 150 ug/ml||Anti-Gram-||Antiviral||Antifungal||candidacidal Homo sapiens|||human mononuclear leukocyte, Homo sapiens N/A human mononuclear leukocyte, Homo sapiens "J Leukoc Biol. 2005 Nov;78(5):1136-41. Pub-Med.|||16204630|||J Leukoc Biol . 2005 Nov;78(5):1136-41. doi: 10.1189/jlb.0505280. Epub 2005 Oct 4.|||J Leukoc Biol. 2005 Nov;78(5):1136-41. Pub-Med." 89 FPDB02965 AP02242|||DRAMP18241 TWATIGKTIVQSVKKCRTFTCGCSLGSCSNCN Anti-Gram+ & Gram-||Antifungal||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- Bacillus subtilis MMA7|||Bacillus thuringiensis N/A Bacillus subtilis MMA7 "Mar Drugs. 2013 Jun 3;11(6):1878-98.Pub-Med.|||Mar Drugs . 2013 Jun 3;11(6):1878-98. doi: 10.3390/md11061878.|||Mar Drugs. 2013 Jun 3;11(6):1878-98." 32 FPDB02966 AP02243|||DRAMP18213|||AP02243|||DRAMP18213 VKLFPVKLFP Anti-bactericidal: active against 15 strains E. faecium, activity value is MIC = 3.9 ug/ml||Anti-15 S. aureus, activity value is MIC = 3.9||Anti-E. cloacae, activity value is MIC = 1.95||Anti-15 P. aeruginosa, activity value is MIC = 31.2||Anti-15 K. pneumoniae, activity value is MIC = 7.8||Anti-and 15 A. baumannii, activity value is MIC = 31.2||Anti-Gram+ & Gram-||Antifungal||Spermicidal||Synergistic AMPs||Hemolytic||Antibiofilm||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram- Bacillus brevis Beta||Beta sheet Bacillus brevis Nature 1944; 154: 703. PDF.||Swierstra et al., 2016|||Nature 1944; 154: 703. PDF.|||Int J Pept Protein Res. 1996 Jun;47(6):460-6.|||Nature 1944; 154: 703. PDF.||Swierstra et al., 2016|||Int J Pept Protein Res. 1996 Jun;47(6):460-6.Biochim Biophys Acta. 2014 May;1838(5):1420-9. 10 FPDB02975 AP02258 CARLNCVPKGTSGNTETCPCYASLHSCRKYG Anti-Lehrer's radial diffusion assay: Active against P. azadirachtae PT, activity value is CC50 = 27||Anti-S. aureus PTCC1442, activity value is MIC = 28.8 ug/ml||Anti-E. coli PTCC2433, activity value is MIC = 13.6 ug/ml||Anti-K. pneumoniae PTCC4231, activity value is MIC = 14.1 ug/ml||Anti-B. subtilis, activity value is MIC = 24.2 ug/ml||Anti-A. niger, activity value is MIC = 9.3 ug/ml||Anti-C. albicans PTCC4236, activity value is MIC = 8.23 ug/ml||Anti-and P. ultimum PT, activity value is CC50 = 21||Anti-Gram+ & Gram-||Antifungal||Antioxidant||Enzyme inhibitor fruits, Zizyphus jujuba N/A fruits, Zizyphus jujuba|||not hemo.lytic at 100 ug/ml "Nat Prod Res. 2013;27(24):2292-6. Pub-Med|||Nat Prod Res . 2013;27(24):2292-6. doi: 10.1080/14786419.2013.827192. Epub 2013 Aug 20" 31 FPDB02977 AP02260|||Pleurain-a1-thel|||Pleurain-a1-thel|||AP02260|||AP02260 RILTMTKRVKMPQLYKQIVCRLFKTC Anti-Gram- E. coli ATCC25922, activity value is MIC = 100 ug/ml||Anti-B. dysenteriae, activity value is MIC = 50 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 50 ug/ml||Anti-B.subtilis ATCC 6633, activity value is MIC > 200 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 10 ug/ml||Anti-including resistant strains C.albicans 08032815, activity value is MIC = 200 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 100 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 50 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 10 ug/ml||Anti-Candida albicans 08030401, activity value is MIC = 50 ug/ml||Anti-Candida albicans 08022821, activity value is MIC = 25 ug/ml||Anti-Candida albicans 08032815, activity value is MIC = 200 ug/ml||Anti-Candida albicans 08030102, activity value is MIC = 100 ug/ml||Anti-Gram+ & Gram-||Antifungal||Antioxidant||Enzyme inhibitor Theloderma kwangsiensis|||Theloderma kwangsiensis|||skin secretions, the tree frog, Theloderma kwangsiensis, Guangxi, China, Asia|||skin secretions, the tree frog, Theloderma kwangsiensis, Guangxi, China, Asia N/A skin secretions, the tree frog, Theloderma kwangsiensis, Guangxi, China, Asia||At a concentration of 100 ug/ml, the hemolysis rate on human red blood cells is 2.5% and on rabbit red blood cells is 3.2%. When the concentration increases to 200 ug/ml, the hemolysis rate on human red blood cells is only 3.7%, and on rabbit red blood cells is 3.5%.|||Human erythrocytes (2.5% Hemolysis at 100 ug/ml|||Human erythrocytes (2.5% Hemolysis at 100 ug/ml|||human RBC 2.5% hemolysis at 100 ug/ml, 3.7% at 200 ug/ml; rabbit RBC: 3.2% at 100 ug/ml and 3.2% at 200 ug/ml. not hemo.lytic. "Zoolog Sci. 2013 Sep;30(9):704-9.Pub-Med|||24004075|||24004075|||Zoolog Sci . 2013 Sep;30(9):704-9. doi: 10.2108/zsj.30.704.|||Zoolog Sci. 2013 Sep;30(9):704-9.Pub-Med" 26 FPDB02978 AP02261 PLGG Active against S. aureus||K. pneumoniae||E. faecalis||S. epidermidis||M. luteus||P. aeruginosa||E. coli||P. mirabilis||S. streptococcus||C. albicans. Warning: However||this molecule may also have undesired property to help bacterial biofilm formation.||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antioxidant a marine actinobacterium, Brevibacterium aureum MSA13 N/A a marine actinobacterium, Brevibacterium aureum MSA13 "Bioresour Technol. 2010 Apr;101(7):2389-96. Pub-Med|||Bioresour Technol . 2010 Apr;101(7):2389-96. doi: 10.1016/j.biortech.2009.11.023. Epub 2009 Dec 2." 4 FPDB02979 AP02262|||Pleurain B1|||DRAMP18699|||Pleurain B1|||AP02262|||DRAMP18699|||AP02262 FLGGLLASLLGKI Anti-E. coli ATCC25922, activity value is MIC = 25 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 1.6 ug/ml||Anti-E. coli, activity value is MIC = 25 ug/ml||Anti-S. aureus, activity value is MIC = 3.1 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 3.1 ug/ml||Anti-C. albicans, activity value is MIC = 1.6 ug/ml||Anti-Escherichia coli, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3.1 ug/ml||Anti-Candida albicans, activity value is MIC = 1.6 ug/ml||Antibacterial||Antifungal||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 3.1 ug/ml||Anti-##Yeast: Candida albicans, activity value is MIC = 1.6 ug/ml||Anti-Gram+ & Gram-||candidacidal||Antioxidant Rana pleuraden|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden|||skin secretions, Rana pleuraden, China, Asia|||Rana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A skin secretions, Rana pleuraden, China, Asia|||No hemolysis information or data found in the reference(s) presented in this entry "Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med|||19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||19028675|||Mol Cell Proteomics . 2009 Mar;8(3):571-83. doi: 10.1074/mcp.M800297-MCP200. Epub 2008 Nov 20.|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med" 13 FPDB02980 AP02263|||Pleurain C1|||DRAMP18700|||Pleurain C1|||AP02263|||DRAMP18700|||AP02263 YPELQQDLIARLL Anti-E. coli ATCC25922, activity value is MIC = 50 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 25 ug/ml||Anti-E. coli, activity value is MIC = 50 ug/ml||Anti-S. aureus, activity value is MIC = 6.3 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 3.1 ug/ml||Anti-C. albicans, activity value is MIC = 25 ug/ml||Anti-Escherichia coli, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 6.3 ug/ml||Anti-Candida albicans, activity value is MIC = 25 ug/ml||Antibacterial||Antifungal||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 6.3 ug/ml||Anti-##Yeast: Candida albicans, activity value is MIC = 25 ug/ml||Anti-Gram+ & Gram-||candidacidal Rana pleuraden|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden|||skin secretions, Rana pleuraden, China, Asia|||Rana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A skin secretions, Rana pleuraden, China, Asia|||No hemolysis information or data found in the reference(s) presented in this entry "Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med|||19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||19028675|||Mol Cell Proteomics . 2009 Mar;8(3):571-83. doi: 10.1074/mcp.M800297-MCP200. Epub 2008 Nov 21.|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med" 13 FPDB02981 AP02264|||Pleurain D1|||Pleurain D1|||AP02264|||DRAMP20782|||AP02264 FLSGILKLAFKIPSVLCAVLKNC Anti-E. coli ATCC25922, activity value is MIC = 25 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 25 ug/ml||Antibacterial||Antifungal||Anti-E. coli, activity value is MIC = 25 ug/ml||Anti-S. aureus, activity value is MIC = 12.5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 50 ug/ml||Anti-C. albicans, activity value is MIC = 25 ug/ml||Anti-Escherichia coli, activity value is MIC = 25 ug/ml||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-##Yeast: Candida albicans, activity value is MIC = 25 ug/ml||Anti-Gram+ & Gram-||candidacidal||Antioxidant Rana pleuraden|||Rana pleuraden|||skin secretions, Rana pleuraden, China, Asia|||Nidirana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A skin secretions, Rana pleuraden, China, Asia|||E. coli (MIC = 25 ug/ml), S. aureus (MIC = 12.5 ug/ml), Bacillus subtilis (MIC = 50 ug/ml), C. albicans (MIC = 25 ug/ml)|||No hemolysis information or data found in the reference(s) presented in this entry "Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med|||19028675|||19028675|||Mol Cell Proteomics . 2009 Mar;8(3):571-83. doi: 10.1074/mcp.M800297-MCP200. Epub 2008 Nov 22.|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med" 23 FPDB02982 AP02265|||Pleurain E1|||DRAMP18702|||Pleurain E1|||AP02265|||DRAMP18702|||AP02265 AKAWGIPPHVIPQIVPVRIRPLCGNV Anti-E. coli ATCC25922, activity value is MIC = 25 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 25 ug/ml||Anti-E. coli, activity value is MIC = 25 ug/ml||Anti-S. aureus, activity value is MIC = 6.3 ug/ml||Anti-C. albicans, activity value is MIC = 25 ug/ml||Anti-Escherichia coli, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 6||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 6||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antioxidant Rana pleuraden|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden|||skin secretions, Rana pleuraden, China, Asia|||Rana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A skin secretions, Rana pleuraden, China, Asia|||No hemolysis information or data found in the reference(s) presented in this entry "Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med|||19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||19028675|||Mol Cell Proteomics . 2009 Mar;8(3):571-83. doi: 10.1074/mcp.M800297-MCP200. Epub 2008 Nov 23.|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med" 26 FPDB02983 AP02266|||Pleurain G1|||DRAMP18703|||Pleurain G1|||AP02266|||DRAMP18703|||AP02266 GFWDSVKEGLKNAAVTILNKIKCKISECPPA Anti-E. coli ATCC25922, activity value is MIC = 50 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 12.5 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 100 ug/ml||Anti-Candida albicans, activity value is MIC = 12.5 ug/ml||Anti-E. coli, activity value is MIC = 50 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-C. albicans, activity value is MIC = 12.5 ug/ml||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-##Yeast: Candida albicans, activity value is MIC = 12.5 ug/ml||Anti-Gram+ & Gram-||candidacidal||Antioxidant Rana pleuraden|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden|||skin secretions, Rana pleuraden, China, Asia|||Rana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A skin secretions, Rana pleuraden, China, Asia|||No hemolysis information or data found in the reference(s) presented in this entry "Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med|||19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||19028675|||Mol Cell Proteomics . 2009 Mar;8(3):571-83. doi: 10.1074/mcp.M800297-MCP200. Epub 2008 Nov 24.|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med" 31 FPDB02984 AP02267|||Pleurain J1|||DRAMP18704|||Pleurain J1|||AP02267|||DRAMP18704|||AP02267 FIPGLRRLFATVVPTVVCAINKLPPG Anti-E. coli ATCC25922, activity value is MIC = 12.5 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 6.3 ug/ml||Anti-E. coli, activity value is MIC = 12.5 ug/ml||Anti-S. aureus, activity value is MIC = 12.5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 50 ug/ml||Anti-C. albicans, activity value is MIC = 6.3 ug/ml||Anti-Escherichia coli, activity value is MIC = 12.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-Candida albicans, activity value is MIC = 6.3 ug/ml||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-##Yeast: Candida albicans, activity value is MIC = 6.3 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antioxidant Rana pleuraden|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden|||skin secretions, Rana pleuraden, China, Asia|||Rana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A skin secretions, Rana pleuraden, China, Asia|||No hemolysis information or data found in the reference(s) presented in this entry "Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med|||19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||19028675|||Mol Cell Proteomics . 2009 Mar;8(3):571-83. doi: 10.1074/mcp.M800297-MCP200. Epub 2008 Nov 25.|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med" 26 FPDB02985 AP02269|||Pleurain R1|||DRAMP18706|||Pleurain R1|||AP02269|||DRAMP18706|||AP02269 CVHWMTNTARTACIAP Anti-E. coli ATCC25922, activity value is MIC = 100 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 50 ug/ml||Anti-E. coli, activity value is MIC = 100 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 100 ug/ml||Anti-C. albicans, activity value is MIC = 50 ug/ml||Anti-Escherichia coli, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Candida albicans, activity value is MIC = 50 ug/ml||Antibacterial||Antifungal||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-##Yeast: Candida albicans, activity value is MIC = 50 ug/ml||Anti-Gram+ & Gram-||candidacidal||Antioxidant Rana pleuraden|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden|||skin secretions, Rana pleuraden, China, Asia|||Rana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A skin secretions, Rana pleuraden, China, Asia|||No hemolysis information or data found in the reference(s) presented in this entry "Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med|||19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||19028675|||Mol Cell Proteomics . 2009 Mar;8(3):571-83. doi: 10.1074/mcp.M800297-MCP200. Epub 2008 Nov 27.|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med" 16 FPDB02986 AP02270|||Pleurain N1|||DRAMP18705|||Pleurain N1|||AP02270|||DRAMP18705|||AP02270 GFFDRIKALTKNVTLELLNTITCKLPVTPP Anti-E. coli ATCC25922, activity value is MIC = 50 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC > 200 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 12.5 ug/ml||Anti-E. coli, activity value is MIC = 50 ug/ml||Anti-S. aureus, activity value is MIC = 12.5 ug/ml||Anti-C. albicans, activity value is MIC = 12.5 ug/ml||Anti-Escherichia coli, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-Candida albicans, activity value is MIC = 12.5 ug/ml||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-##Yeast: Candida albicans, activity value is MIC = 12.5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Rana pleuraden|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden|||skin secretions, Rana pleuraden, China, Asia|||Rana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A skin secretions, Rana pleuraden, China, Asia|||No hemolysis information or data found in the reference(s) presented in this entry "Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med|||19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||19028675|||Mol Cell Proteomics . 2009 Mar;8(3):571-83. doi: 10.1074/mcp.M800297-MCP200. Epub 2008 Nov 28.|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med" 30 FPDB02987 AP02271|||Pleurain-D4|||DRAMP18701|||Pleurain-D4|||AP02271|||DRAMP18701|||AP02271 FRSGILKLASKIPSVLCAVLKNC Anti-E. coli ATCC25922, activity value is MIC = 50 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 25 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli, activity value is MIC = 50 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 50 ug/ml||Anti-Candida albicans, activity value is MIC = 25 ug/ml||Anti-E. coli, activity value is MIC = 50 ug/ml||Anti-S. aureus, activity value is MIC = 12.5 ug/ml||Anti-C. albicans, activity value is MIC = 25 ug/ml||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-##Yeast: Candida albicans, activity value is MIC = 25 ug/ml||Anti-Gram+ & Gram-||candidacidal Rana pleuraden|||Rana pleuraden (Yunnan pond frog)|||Rana pleuraden|||skin secretions, Rana pleuraden, China, Asia|||Rana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A skin secretions, Rana pleuraden, China, Asia|||E. coli (MIC = 50 ug/ml), S. aureus (MIC = 12.5 ug/ml), Bacillus subtilis (MIC = 50 ug/ml), C. albicans (MIC = 25 ug/ml)|||No hemolysis information or data found in the reference(s) presented in this entry "Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med|||19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||19028675|||Mol Cell Proteomics . 2009 Mar;8(3):571-83. doi: 10.1074/mcp.M800297-MCP200. Epub 2008 Nov 29.|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med" 23 FPDB02991 AP02274 FISGLIGGLMKAL Anti-S. aureus ATCC 25923, activity value is MIC = 25 uM||Anti-E.faecium 091299, activity value is MIC > 400 uM||Anti-E. faecalis 981, activity value is MIC = 50 uM||Anti-N. asteroides 201118, activity value is MIC = 25 uM||Anti-P.aeruginosa, activity value is MIC > 400 uM||Anti-K.Pneumoniae 08040724, activity value is MIC > 400 uM||Anti-E.cloacae CGMCC 1.57, activity value is MIC = 400 uM||Anti-E.coli ATCC 25922, activity value is MIC > 400 uM||Anti-P.faecalis X29, activity value is MIC = 200 uM||Anti-C. glabrata 090902, activity value is MIC = 100 uM||Anti-C.albicans ATCC10231, activity value is MIC > 400 uM||Anti-Gram+||Antifungal skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia N/A skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia||At 200 uM, the hemolysis rate ranges from 51.6% to 53.4%, showing weak activity.|||HC50 >200 uM, 11.2% hemolysis at 200 uM, poor hemo.lytic. "Biochimie. 2013 Dec;95(12):2429-36. Pub-Med|||Biochimie . 2013 Dec;95(12):2429-36. doi: 10.1016/j.biochi.2013.09.002. Epub 2013 Sep 18" 13 FPDB02992 AP02275 FITGLISGLMKAL Anti-S. aureus ATCC 25923, activity value is MIC = 12.5 uM||Anti-E.faecium 091299, activity value is MIC > 400 uM||Anti-E. faecalis 981, activity value is MIC = 25 uM||Anti-N. asteroides 201118, activity value is MIC = 12.5 uM||Anti-P.aeruginosa, activity value is MIC > 400 uM||Anti-K.Pneumoniae 08040724, activity value is MIC > 400 uM||Anti-E.cloacae CGMCC 1.57, activity value is MIC > 400 uM||Anti-E.coli ATCC 25922, activity value is MIC > 400 uM||Anti-P.faecalis X29, activity value is MIC = 200 uM||Anti-C. glabrata 090902, activity value is MIC = 100 uM||Anti-C.albicans ATCC10231, activity value is MIC > 400 uM||Anti-Gram+||Antifungal skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia N/A skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia||At a concentration of 50 uM, the hemolysis rate is 0; when the concentration reaches 100 uM, the hemolysis rate is 11.1%; and when the concentration is increased to 200 uM, the hemolysis rate is 51.6%.|||HC50~200 uM, low hemo.lytic "Biochimie. 2013 Dec;95(12):2429-36. Pub-Med|||Biochimie . 2013 Dec;95(12):2429-36. doi: 10.1016/j.biochi.2013.09.002. Epub 2013 Sep 19" 13 FPDB02994 AP02278|||Brevinin-1SN1|||Brevinin-1SN1|||AP02278|||AP02278 FLPAVLKVAAHILPTAICAISRRC Anti-S. aureus ATCC 25923, activity value is MIC = 3.1 uM||Anti-E. faecium 091299, activity value is MIC = 50 uM||Anti-E. faecalis 981, activity value is MIC = 3.1 uM||Anti-N. asteroides 201118, activity value is MIC = 3.1 uM||Anti-P.aeruginosa, activity value is MIC > 400 uM||Anti-K.Pneumoniae 08040724, activity value is MIC > 400 uM||Anti-E. cloacae CGMCC 1.57, activity value is MIC = 100 uM||Anti-E.coli ATCC 25922, activity value is MIC > 400 uM||Anti-P. faecalis X29, activity value is MIC = 25 uM||Anti-C. glabrata 090902, activity value is MIC = 12.5 uM||Anti-C.albicans ATCC10231, activity value is MIC > 400 uM||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.1 uM||Anti-Enterococcus faecalis 981, activity value is MIC = 3.1 uM||Anti-Nocardia asteroides 201118, activity value is MIC = 3.1 uM||Anti-Enterobacter cloacae CGMCC 1.57, activity value is MIC = 100 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 25 uM||Anti-Candida glabrata 090902, activity value is MIC = 12.5 uM||Anti-Enterococcus faecium 091299, activity value is MIC = 50 uM||Anti-Gram+ & Gram- Hylarana Spinulosa [fine-spined frog]|||Hylarana Spinulosa [fine-spined frog]|||skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia|||skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia N/A skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia||At 200 uM, the hemolysis rates are 50.2% and 90.2% respectively, showing moderate activity.|||Hemolytic activity (200 uM, 50.2 % hemolysis, Human RBC)|||Hemolytic activity (200 uM, 50.2 % hemolysis, Human RBC)|||HC50 ~200 uM, low hemo.lytic "Biochimie. 2013 Dec;95(12):2429-36. Pub-Med|||24055160|||24055160|||Biochimie . 2013 Dec;95(12):2429-36. doi: 10.1016/j.biochi.2013.09.002. Epub 2013 Sep 20|||Biochimie. 2013 Dec;95(12):2429-36. Pub-Med" 24 FPDB02995 AP02279|||Brevinin-1SN2|||Brevinin-1SN2|||AP02279|||AP02279 FMGTALKIAANVLPAAFCKIFKKC Anti-S. aureus ATCC 25923, activity value is MIC = 3.1 uM||Anti-E. faecium 091299, activity value is MIC = 100 uM||Anti-E. faecalis 981, activity value is MIC = 3.1 uM||Anti-N. asteroides 201118, activity value is MIC = 3.1 uM||Anti-P.aeruginosa, activity value is MIC = 400 uM||Anti-K.Pneumoniae 08040724, activity value is MIC = 400 uM||Anti-E. cloacae CGMCC 1.57, activity value is MIC = 100 uM||Anti-E.coli ATCC 25922, activity value is MIC = 200 uM||Anti-P. faecalis X29, activity value is MIC = 12.5 uM||Anti-C. glabrata 090902, activity value is MIC = 12.5 uM||Anti-C. albicans ATCC10231, activity value is MIC = 100 uM||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.1 uM||Anti-Enterococcus faecalis 981, activity value is MIC = 3.1 uM||Anti-Nocardia asteroides 201118, activity value is MIC = 3.1 uM||Anti-Enterobacter cloacae CGMCC 1.57, activity value is MIC = 100 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 12.5 uM||Anti-Candida glabrata 090902, activity value is MIC = 12.5 uM||Anti-Enterococcus faecium 091299, activity value is MIC = 100 uM||Anti-Pseudomonas aeruginosa CGMCC 1.50, activity value is MIC = 400 uM||Anti-Klebsiella Pneumoniae 08040724, activity value is MIC = 400 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 200 uM||Anti-Candida albicans ATCC10231, activity value is MIC = 100 uM||Anti-Gram+ & Gram-||Hemolytic Hylarana Spinulosa [fine-spined frog]|||Hylarana Spinulosa [fine-spined frog]|||skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia|||skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia N/A skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia||At 50 uM, the hemolysis rates are 51.5% and 50.1% respectively, and both reach 100% hemolysis at 200 uM.|||Hemolytic activity (200 uM, 100 % hemolysis, Human RBC)|||Hemolytic activity (200 uM, 100 % hemolysis, Human RBC)|||HC50 = 50 uM, moderate hemolytic. "Biochimie. 2013 Dec;95(12):2429-36. Pub-Med|||24055160|||24055160|||Biochimie . 2013 Dec;95(12):2429-36. doi: 10.1016/j.biochi.2013.09.002. Epub 2013 Sep 21|||Biochimie. 2013 Dec;95(12):2429-36. Pub-Med" 24 FPDB02998 AP02282|||Brevinin-2SN3|||Brevinin-2SN3|||AP02282|||AP02282 GAFGNLLKGVAKKAGLKILSIAQCKLSGTC Anti-S. aureus ATCC 25923, activity value is MIC = 3.1 uM||Anti-E. faecium 091299, activity value is MIC = 6.3 uM||Anti-E. faecalis 981, activity value is MIC = 3.1 uM||Anti-N. asteroides 201118, activity value is MIC = 3.1 uM||Anti-P. aeruginosa, activity value is MIC = 100 uM||Anti-K. Pneumoniae 08040724, activity value is MIC = 25 uM||Anti-E. cloacae CGMCC 1.57, activity value is MIC = 12.5 uM||Anti-E. coli ATCC 25922, activity value is MIC = 25 uM||Anti-P. faecalis X29, activity value is MIC = 3.1 uM||Anti-C. glabrata 090902, activity value is MIC = 100 uM||Anti-C.albicans ATCC10231, activity value is MIC > 400 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.1 uM||Anti-Enterococcus faecalis 981, activity value is MIC = 3.1 uM||Anti-Nocardia asteroides 201118, activity value is MIC = 3.1 uM||Anti-Enterobacter cloacae CGMCC 1.57, activity value is MIC = 12.5 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 3.1 uM||Anti-Candida glabrata 090902, activity value is MIC = 100 uM||Anti-Enterococcus faecium 091299, activity value is MIC = 6.3 uM||Anti-Pseudomonas aeruginosa CGMCC 1.50, activity value is MIC = 100 uM||Anti-Klebsiella Pneumoniae 08040724, activity value is MIC = 25 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 25 uM||Anti-Gram+ & Gram-||Antifungal Hylarana Spinulosa [fine-spined frog]|||Hylarana Spinulosa [fine-spined frog]|||skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia|||skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia N/A skin, fine-spined frog, Hylarana spinulosa, Hainan, China, Asia||At 200 uM, the hemolysis rate ranges from 51.6% to 53.4%, showing weak activity.|||Hemolytic activity (200 uM, 53.4 % hemolysis, Human RBC)|||Hemolytic activity (200 uM, 53.4 % hemolysis, Human RBC)|||HC50~200 uM, poor hemo.lytic. "Biochimie. 2013 Dec;95(12):2429-36. Pub-Med|||24055160|||24055160|||Biochimie . 2013 Dec;95(12):2429-36. doi: 10.1016/j.biochi.2013.09.002. Epub 2013 Sep 22|||Biochimie. 2013 Dec;95(12):2429-36. Pub-Med" 30 FPDB03000 AP02283|||CPF-St4|||CPF-St4|||AP02283|||AP02283 SLFGTFAKMALKGASKLIPHLLPSRQQ Anti-Gram- E. coli, activity value is MIC = 2||Anti-P. aeruginosa, activity value is MIC = 4||Anti-S. aureus, activity value is MIC = 1 uM||Anti-M. luteus, activity value is MIC = 0.5 uM||Anti-S. cerevisiae, activity value is MIC = 16 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 4||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 1 uM||Anti-Micrococcus luteus, activity value is MIC = 0.5 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 16 uM||Anti-Gram+ & Gram-||Antifungal||Antiparasitic||Hemolytic Synthetic construct|||Synthetic construct|||the African clawed frog Silurana tropicalis|||the African clawed frog Silurana tropicalis N/A the African clawed frog Silurana tropicalis||The hemolytic activity is moderate, with an HC₅₀ of 64 uM for both.|||Mouse erythrocytes (50% Hemolysis at 64 uM|||Mouse erythrocytes (50% Hemolysis at 64 uM "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||23935531|||23935531|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 1.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 27 FPDB03001 AP02284|||CPF-St5|||CPF-St5|||AP02284|||AP02284 GVFGLLAKAALKGASKLIPHLLPSRQQ Anti-Gram- E. coli, activity value is MIC = 1 uM||Anti-P. aeruginosa, activity value is MIC = 4||Anti-S. aureus, activity value is MIC = 1 uM||Anti-M. luteus, activity value is MIC = 0.5 uM||Anti-S. cerevisiae, activity value is MIC = 16 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 4||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 1 uM||Anti-Micrococcus luteus, activity value is MIC = 0.5 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 16 uM||Anti-Gram+ & Gram-||Antifungal||Antiparasitic||Hemolytic Synthetic construct|||Synthetic construct|||the African clawed frog Silurana tropicalis|||the African clawed frog Silurana tropicalis N/A the African clawed frog Silurana tropicalis||The hemolytic activity is moderate, with an HC₅₀ of 64 uM for both.|||Mouse erythrocytes (50% Hemolysis at 64 uM|||Mouse erythrocytes (50% Hemolysis at 64 uM|||Toxicity to erythrocytes (HC50 64 uM) moderate hemolytic and T-lymphocytes (IC50 8 uM) "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||23935531|||23935531|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 2.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 27 FPDB03002 AP02285|||CPF-St6|||CPF-St6|||AP02285|||AP02285 KLGFENFLVKALKTVMHVPTSPLL Anti-Gram- E. coli, activity value is MIC = 16 uM||Anti-P.aeruginosa, activity value is MIC > 256 uM||Anti-S.aureus, activity value is MIC > 256 uM||Anti-M. luteus, activity value is MIC = 4 uM||Anti-S. cerevisiae, activity value is MIC = 64 uM||Antibacterial||Antiparasitic||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 16 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC > 256 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 256 uM||Anti-Micrococcus luteus, activity value is MIC = 4 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 64 uM||Anti-Gram+ & Gram- Synthetic construct|||Synthetic construct|||the African clawed frog Silurana tropicalis|||the African clawed frog Silurana tropicalis N/A the African clawed frog Silurana tropicalis||The concentration causing 50% hemolysis (HC₅₀) ranges from 256 uM.|||Mouse erythrocytes (50% Hemolysis at 256 uM|||Mouse erythrocytes (50% Hemolysis at 256 uM|||not hemo.lytic "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||23935531|||23935531|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 3.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 24 FPDB03003 AP02286|||CPF-St7, Pxt-12|||DRAMP29147|||CPF-St7, Pxt-12|||AP02286|||AP02286 NLLGSLLKTGLKVGSNLL Anti-Gram- E.coli, activity value is MIC = 128 uM||Anti-P.aeruginosa, activity value is MIC > 256 uM||Anti-S. aureus, activity value is MIC = 32 uM||Anti-M. luteus, activity value is MIC = 2 uM||Anti-S. cerevisiae, activity value is MIC = 64 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 128 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC > 256 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 32 uM||Anti-Micrococcus luteus, activity value is MIC = 2 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 64 uM||Anti-Escherichia coli NBRC 14237, activity value is MIC < 12.5 uM||Anti-Pseudomonas aeruginosa NBRC 12582, activity value is MIC < 50 uM||Anti-Staphylococcus aureus NBRC 12732, activity value is MIC < 12.5 uM||Anti-Micrococcus luteus NBRC 12708, activity value is MIC < 50 uM||Anti-Candida albicans NBRC 1594 . Gram-negative bacteria:Escherichia coli ATCC 25922, activity value is MIC = 128 uM||Anti-Gram-||Antifungal||Antiparasitic Synthetic construct|||Xenopus tropicalis|||the African clawed frog Silurana tropicalis|||the African clawed frog Silurana tropicalis Alpha helix,random coil "the African clawed frog Silurana tropicalis||The concentration that causes 50% hemolysis of red blood cells (HC₅₀) is 256 uM.|||Mouse erythrocytes (50% Hemolysis at 256 uM, Mouse splenocytes (IC50 at 128 uM|||1. Pxt-related peptides - Pxt-2: 2.0% - Pxt-5: 69.8% - Pxt-12: 0% - Reverse Pxt-2: 1.5% - Reverse Pxt-5: 5.2% - Reverse Pxt-12: 0% 2. Reference peptides - Mastoparan: 13.5% - Melittin: 100% (completely hemolytic at a concentration of 10 µM) - Magainin 1: not measured (-)|||Mouse erythrocytes (50% Hemolysis at 256 uM, Mouse splenocytes (IC50 at 128 uM|||not hemo.lytic" "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||23935531, 26802742|||PLoS Genet. 2013;9(8):e1003662.||Ref.26802742||Ref.23935531|||23935531, 26802742|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 4.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 18 FPDB03005 AP02288|||XPF-St4|||XPF-St4|||AP02288|||AP02288 GWASSIGSILGKFAKGGAQAFLQPK Anti-Gram- E. coli, activity value is MIC = 32 uM||Anti-Paeruginosa, activity value is MIC = 128 uM||Anti-S.aureus, activity value is MIC > 256 uM||Anti-M. luteus, activity value is MIC = 0.5 uM||Anti-S. cerevisiae, activity value is MIC = 64 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 32 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 128 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 256 uM||Anti-Micrococcus luteus, activity value is MIC = 0.5 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 64 uM||Anti-Gram+ & Gram-||Antifungal||Antiparasitic Silurana tropicalis|||Silurana tropicalis|||the African clawed frog Silurana tropicalis|||the African clawed frog Silurana tropicalis N/A the African clawed frog Silurana tropicalis||HC₅₀ = 64 uM.|||Mouse erythrocytes (50% Hemolysis at 256 uM|||Mouse erythrocytes (50% Hemolysis at 256 uM "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||23935531|||23935531|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 5.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 25 FPDB03006 AP02289|||XPF-St5|||XPF-St5|||AP02289|||AP02289 GWLPTFGKILRKAMQLGPKLIQPI Anti-Gram- E. coli, activity value is MIC = 1||Anti-P. aeruginosa, activity value is MIC = 8||Anti-S. aureus, activity value is MIC = 16 uM||Anti-M. luteus, activity value is MIC = 1 uM||Anti-S. cerevisiae, activity value is MIC = 32 uM||Antibacterial||Antiparasitic||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 16 uM||Anti-Micrococcus luteus, activity value is MIC = 1 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 32 uM||Anti-Gram+ & Gram- Synthetic construct|||Synthetic construct|||the African clawed frog Silurana tropicalis|||the African clawed frog Silurana tropicalis N/A the African clawed frog Silurana tropicalis||HC₅₀ = 128 uM.|||Mouse erythrocytes (50% Hemolysis at 128 uM|||Mouse erythrocytes (50% Hemolysis at 128 uM "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||23935531|||23935531|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 6.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 24 FPDB03007 AP02290|||XT-2|||AP02290 GVWSTVLGGLKKFAKGGLEAIVNPK Anti-Gram- E. coli, activity value is MIC = 4 uM||Anti-P. aeruginosa, activity value is MIC = 32 uM||Anti-S. aureus, activity value is MIC = 32||Anti-M. luteus, activity value is MIC = 0.5 uM||Anti-S. cerevisiae, activity value is MIC = 32 uM||Antibacterial||Anti-Gram+ & Gram-||Antifungal||Antiparasitic Xenopus tropicalis [Western clawed frog]|||the African clawed frog Silurana tropicalis N/A the African clawed frog Silurana tropicalis||HC₅₀ = 64 uM.|||Staphylococcus aureus (MIC = >100 uM), E.coli (MIC = 8 uM) "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||11738090|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 7.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 25 FPDB03008 AP02291|||XPF-St6|||XPF-St6|||AP02291|||AP02291 GVWSTILGGLKKFAKGGLDAIVNPK Anti-Gram- E. coli, activity value is MIC = 2||Anti-P. aeruginosa, activity value is MIC = 16 uM||Anti-S. aureus, activity value is MIC = 8||Anti-M. luteus, activity value is MIC = 0.5 uM||Anti-S. cerevisiae, activity value is MIC = 8 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 16 uM||Anti-Micrococcus luteus, activity value is MIC = 0.5 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 8 uM||Anti-Gram+ & Gram-||Antifungal||Antiparasitic||Hemolytic Synthetic construct|||Synthetic construct|||the African clawed frog Silurana tropicalis|||the African clawed frog Silurana tropicalis N/A the African clawed frog Silurana tropicalis||HC₅₀ = 64 uM.|||Mouse erythrocytes (50% Hemolysis at 64 uM|||Mouse erythrocytes (50% Hemolysis at 64 uM "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||23935531|||23935531|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 8.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 25 FPDB03009 AP02292|||XPF-St7|||XPF-St7|||AP02292|||AP02292 GLLSNVAGLLKQFAKGGVNAVLNPK Anti-Gram- E. coli, activity value is MIC = 8 uM||Anti-P. aeruginosa, activity value is MIC = 32 uM||Anti-S.aureus, activity value is MIC = 128 uM||Anti-M. luteus, activity value is MIC = 1 uM||Anti-S. cerevisiae, activity value is MIC = 32 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 32 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 128 uM||Anti-Micrococcus luteus, activity value is MIC = 1 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||Antiparasitic Silurana tropicalis|||Silurana tropicalis|||the African clawed frog Silurana tropicalis|||the African clawed frog Silurana tropicalis N/A the African clawed frog Silurana tropicalis||Only when the concentration reaches 256 uM and above will half of the red blood cells of the tested mice undergo hemolysis.|||Mouse erythrocytes (50% Hemolysis at >256 uM|||Mouse erythrocytes (50% Hemolysis at >256 uM "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||23935531|||23935531|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 9.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 25 FPDB03010 AP02293|||XPF-St8|||XPF-St8|||AP02293|||AP02293 GFMSKVANFAKKFAKGGVNAIMNQK Anti-Gram- E. coli, activity value is MIC = 1 uM||Anti-P. aeruginosa, activity value is MIC = 4 uM||Anti-S.aureus, activity value is MIC = 128 uM||Anti-M. luteus, activity value is MIC = 0.5 uM||Anti-S. cerevisiae, activity value is MIC = 8 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 4 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 128 uM||Anti-Micrococcus luteus, activity value is MIC = 0.5 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 8 uM||Anti-Gram+ & Gram-||Antifungal||Antiparasitic||Hemolytic Synthetic construct|||Synthetic construct|||the African clawed frog Silurana tropicalis|||the African clawed frog Silurana tropicalis N/A the African clawed frog Silurana tropicalis||HC₅₀ = 64 uM.|||Mouse erythrocytes (50% Hemolysis at 64 uM|||Mouse erythrocytes (50% Hemolysis at 64 uM|||HC50, the lowest polypeptide concentration that results in at least 50% hemolysis, and the percent hemolysis for each polypeptide concentration is calculated as 1006(ODobs2OD0%)/(OD100%2OD0%), where ODobs is the OD of the measured polypeptide concentration, OD0% is the average OD in the absence of peptide (0% hemolysis), and OD100% is the average OD in the presence of 1% Tween-20 (100% hemolysis). "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||23935531|||23935531|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 1.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 25 FPDB03012 AP02295|||PGLa-St2|||PGLa-St2|||AP02295|||AP02295 GMATKAGTAFGKAAKAIIGAAL Anti-Gram- E. coli, activity value is MIC = 16 uM||Anti-P.aeruginosa, activity value is MIC = 128 uM||Anti-S.aureus, activity value is MIC > 256 uM||Anti-M. luteus, activity value is MIC = 2 uM||Anti-S. cerevisiae, activity value is MIC = 64 uM||Antibacterial||Antiparasitic||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 16 uM||Anti-Pseudomonas aeruginosa ATCC 15692, activity value is MIC = 128 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 256 uM||Anti-Micrococcus luteus, activity value is MIC = 2 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 64 uM||Anti-Gram+ & Gram- Synthetic construct|||the African clawed frog Silurana tropicalis N/A the African clawed frog Silurana tropicalis||HC₅₀ ＞ 256 uM.|||Mouse erythrocytes (50% Hemolysis at >256 uM|||Mouse erythrocytes (50% Hemolysis at >256 uM "PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med|||23935531|||23935531|||PLoS Genet . 2013;9(8):e1003662. doi: 10.1371/journal.pgen.1003662. Epub 2013 Aug 1.|||PLoS Genet. 2013 Aug;9(8):e1003662. Pub-Med" 22 FPDB03013 AP02296|||Temporin-1RNa|||AP02296 ILPIRSLIKKLL Anti-P. aeruginosa, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 12.5 uM||Anti-S. lactis, activity value is MIC = 6.25 uM||Anti-C. albicans, activity value is MIC = 12.5 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Anticancer Rana nigromaculata|||the black-spotted frog, Rana nigromaculata ,Northeastern China, Asia|||the black-spotted frog, Rana nigromaculata ,Northeastern China, Asia Helix the black-spotted frog, Rana nigromaculata ,Northeastern China, Asia|||Human erythrocytes (50% Hemolysis at 105.2+-10.2 uM|||HC50 (50% hemolysis at 105 uM "World J Microbiol Biotechnol. 2013 Oct;29(10):1941-9. Pub-Med|||23632907|||World J Microbiol Biotechnol . 2013 Oct;29(10):1941-9. doi: 10.1007/s11274-013-1360-y. Epub 2013 Apr 30." 12 FPDB03014 AP02297|||CAMPSQ19683|||Temporin-1RNb|||AP02297|||AP02297 FLPLKKLRFGLL Anti-P. aeruginosa, activity value is MIC = 12.5 uM||Anti-S. lactis, activity value is MIC = 3.13 uM||Anti-C. albicans, activity value is MIC = 6.25 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Anticancer Rana nigromaculata|||Rana nigromaculata|||the black-spotted frog, Rana nigromaculata ,Northeastern China, Asia|||the black-spotted frog, Rana nigromaculata ,Northeastern China, Asia Helix the black-spotted frog, Rana nigromaculata ,Northeastern China, Asia|||Human erythrocytes (50% Hemolysis at 136.3+-5.6 uM|||Human erythrocytes (50% Hemolysis at 136.3+-5.6 uM|||HC50 (50% hemolysis at 136 uM. "World J Microbiol Biotechnol. 2013 Oct;29(10):1941-9. Pub-Med|||23632907|||23632907|||World J Microbiol Biotechnol . 2013 Oct;29(10):1941-9. doi: 10.1007/s11274-013-1360-y. Epub 2013 Apr 30.|||World J Microbiol Biotechnol. 2013 Oct;29(10):1941-9. Pub-Med" 12 FPDB03018 AP02301 RISKKKGKGSWIKNGLIKGIKGLGKEISLDVIRTGIDIAGCKIKGEC Anti-S. aureus ATCC2592, activity value is MIC = 0.6 uM||Anti-B. licheniformis X39, activity value is MIC = 10 uM||Anti-S. carnosus KHS, activity value is MIC = 1.3 uM||Anti-R. rhodochrous X15, activity value is MIC = 0.3 uM||Anti-E. coli ATCC 25922, activity value is MIC = 5 uM||Anti-S. rubidaea X01, activity value is MIC = 10 uM||Anti-P. faecalis X29, activity value is MIC = 0.6 uM||Anti-and C. albicans ATCC2002, activity value is MIC = 80 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal the broad-folded frog, Hylarana latouchii, China, Asia N/A the broad-folded frog, Hylarana latouchii, China, Asia||(LD₅₀) is greater than 480 uM.|||The LD50 value is determined as the average concentration of the peptide that produces 50% hemolysis.|||Hemolytic HC50 >480 uM "Biochimie. 2012 Jun;94(6):1317-26. Pub-Med|||Biochimie . 2012 Jun;94(6):1317-26. doi: 10.1016/j.biochi.2012.02.032. Epub 2012 Mar 8." 47 FPDB03022 AP02306|||Lf-CATH1|||Lf-CATH1|||AP02306|||AP02306 PPCRGIFCRRVGSSSAIARPGKTLSTFITV Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 1.26 uM||Anti-Staphylococcus aureus, activity value is MIC = 2.52 uM||Anti-Staphylococcus aureus 1303, activity value is MIC = 1.25 uM||Anti-Staphylococcus aureus 1307, activity value is MIC > 32.9 uM||Anti-Staphylococcus aureus 1349, activity value is MIC = 10.1 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 5.04 uM||Anti-Cutibacterium acnes ATCC 11827, activity value is MIC = 10.1 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 10.1 uM||Anti-Pseudomonas aeruginosa 1411, activity value is MIC = 10.1 uM||Anti-Pseudomonas aeruginosa 1412, activity value is MIC = 10.1 uM||Anti-Pseudomonas aeruginosa 1413, activity value is MIC = 10.1 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.52 uM||Anti-Escherichia coli 1334, activity value is MIC = 2.52 uM||Anti-Escherichia coli 1342, activity value is MIC = 5.04 uM||Anti-Klebsiella pneumoniae 1368, activity value is MIC = 10.1 uM||Anti-Proteus vulgaris, activity value is MIC > 32.9 uM||Anti-Candida albicans ATCC 2002, activity value is MIC = 1.26 uM||Anti-Candida glabrata 0902, activity value is MIC = 5.04 uM Limnonectes fragilis|||Limnonectes fragilis|||spleen, liver and kidney, fragile large-headed frog, fragile wart frog, Limnonectes fragilis, Hainan, China, Asia|||spleen, liver and kidney, fragile large-headed frog, fragile wart frog, Limnonectes fragilis, Hainan, China, Asia N/A spleen, liver and kidney, fragile large-headed frog, fragile wart frog, Limnonectes fragilis, Hainan, China, Asia||At a high concentration of 100 uM (>25 times the MIC value), it induces 9.5% hemolysis of human red blood cells.|||Human erythrocytes (10% Hemolysis at 100 uM|||Human erythrocytes (10% Hemolysis at 100 uM|||When the concentration is 100 uM (~25 times the MIC value), LF-CATH1 and -2 induce hemolysis in only 9.5% and 13.5% of human red blood cells, respectively. "FEBS J. 2013 Sep 13. doi: 10.1111/febs.12521.Pub-Med|||24028327|||24028327|||FEBS J . 2013 Dec;280(23):6022-32. doi: 10.1111/febs.12521. Epub 2013 Oct 25.|||FEBS J. 2013 Sep 13. doi: 10.1111/febs.12521.Pub-Med" 30 FPDB03023 AP02307|||Lf-CATH2|||Lf-CATH2|||AP02307|||AP02307 GKCNVLCQLKQKLRSIGSGSHIGSVVLPRG Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 2.27 uM||Anti-Staphylococcus aureus, activity value is MIC = 2.27 uM||Anti-Staphylococcus aureus 1303, activity value is MIC = 4.54 uM||Anti-Staphylococcus aureus 1349, activity value is MIC = 9.08 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 4.54 uM||Anti-Cutibacterium acnes ATCC 11827, activity value is MIC = 18.2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 4.54 uM||Anti-Pseudomonas aeruginosa 1411, activity value is MIC = 4.54 uM||Anti-Pseudomonas aeruginosa 1412, activity value is MIC = 9.08 uM||Anti-Pseudomonas aeruginosa 1413, activity value is MIC = 4.54 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.27 uM||Anti-Escherichia coli 1334, activity value is MIC = 4.54 uM||Anti-Escherichia coli 1342, activity value is MIC = 9.08 uM||Anti-Candida albicans ATCC 2002, activity value is MIC = 1.13 uM||Anti-Candida glabrata 0902, activity value is MIC = 4.54 uM Limnonectes fragilis|||Limnonectes fragilis|||fragile large-headed frog, fragile wart frog, Limnonectes fragilis, Hainan, China, Asia|||fragile large-headed frog, fragile wart frog, Limnonectes fragilis, Hainan, China, Asia N/A fragile large-headed frog, fragile wart frog, Limnonectes fragilis, Hainan, China, Asia||At a high concentration of 100 uM (>25 times the MIC value), it induces 13.5% hemolysis of human red blood cells.|||Human erythrocytes (14% Hemolysis at 100 uM|||Human erythrocytes (14% Hemolysis at 100 uM|||When the concentration is 100 uM (~25 times the MIC value), LF-CATH1 and -2 induce hemolysis in only 9.5% and 13.5% of human red blood cells, respectively. "FEBS J. 2013 Sep 13. doi: 10.1111/febs.12521.Pub-Med|||24028327|||24028327|||FEBS J . 2013 Dec;280(23):6022-32. doi: 10.1111/febs.12521. Epub 2013 Oct 25.|||FEBS J. 2013 Sep 13. doi: 10.1111/febs.12521.Pub-Med" 30 FPDB03038 AP02331|||Defensin|||DRAMP03006|||AP02331|||DRAMP03006|||AP02331 VTCDLLSIKGVAEHSACAANCLSMGKAGGRCENGICLCRKTTFKELWDKRF Active against M. luteus||E. coli||and filamentus fungus N. crassa.||Antibacterial||Antifungal ; M. luteus||E. coli D22||Antimicrobial||Anti-Gram+||Antifungal||Anti-Gram+ & Gram- Bombus pascuorum [Brown bumblebee]|||Bombus pascuorum (Brown bumblebee)|||European bumblebee Bombus pascuorum|||Bombus pascuorum (Brown bumblebee)|||European bumblebee Bombus pascuorum Bridge European bumblebee Bombus pascuorum "Insect Biochem Mol Biol. 1997 May;27(5):413-22. PubMed|||9219367|||Insect Biochem Mol Biol. 1997 May;27(5):413-422.|||Insect Biochem Mol Biol . 1997 May;27(5):413-22. doi: 10.1016/s0965-1748(97)00013-1.|||Insect Biochem Mol Biol. 1997 May;27(5):413-422.|||Insect Biochem Mol Biol. 1997 May;27(5):413-22. PubMed" 51 FPDB03039 AP02333 KIIFLIAI Active against C. glabrata and E. amylovora (at 25 uM). E. amylovora is responsible for Fire blight (fireblight) that is a contagious disease affecting apples||pears||etc.||Anti-Gram-||Antifungal marine sediments of the Gotland Deep (Baltic Sea), Streptomyces champavatii N/A marine sediments of the Gotland Deep (Baltic Sea), Streptomyces champavatii "Mar Drugs. 2013 Dec 2;11(12):4834-57. PubMed|||Mar Drugs . 2013 Dec 2;11(12):4834-57. doi: 10.3390/md11124834." 8 FPDB03040 AP02341 LVKDNPLDISPKQVQALCTDLVIRCMCCC Anti-Gram+||Antifungal||candidacidal potato, Sanum tuberosum L cv. Gogu Valley N/A potato, Sanum tuberosum L cv. Gogu Valley||At a high concentration of 40 uM, the hemolysis rate induced by PG-2 is 0%, showing a complete absence of hemolytic effect.|||At a concentration of up to 40 μM, the hemolytic activity of PG-2 was 0%, while the positive control melittin could induce about 100% hemolysis at 2.5 μM (Figure 3D).|||The hemolytic activity of PG-2 was determined to be 0% at concentrations up to 40 uM, whereas melittin, a positive control, induced about 100% hemolysis at 2.5 uM (Figure 3D). "Int J Mol Sci. 2013 Feb 21;14(2):4349-60. doi: 10.3390/ijms14024349. PubMed|||Int J Mol Sci . 2013 Feb 21;14(2):4349-60. doi: 10.3390/ijms14024349.|||Int J Mol Sci. 2013 Feb 21;14(2):4349-60. doi: 10.3390/ijms14024349. PubMed" 29 FPDB03041 AP02342|||DRAMP00277|||AP02342|||DRAMP00277 DICTNCCAGTKGCNTTSANGAFICEGQSDPKKPKACPLNCDPHIAYA Anti-Gram+||Antifungal||candidacidal||Enzyme inhibitor||Anti-Candida albicans, activity value is MIC = 100 uM||Anti-Clavibacter michiganensis, activity value is MIC = 50 uM||Antimicrobial||Antibacterial Solanum tuberosum (Potato)|||potato, Solanum tuberosum L cv. Gogu|||Solanum tuberosum (Potato)|||potato, Solanum tuberosum L cv. Gogu N/A potato, Solanum tuberosum L cv. Gogu||Within the tested concentration range (0.31–40 uM), the hemolysis rate induced by PT-1 is 0% across the board, showing a complete absence of hemolytic effect.|||The hemolytic value of the potato-derived trypsin-chymotrypsin inhibitor potamin-1 (PT-1) is as follows: within the concentration range of 0.31–40 μM, the hemolysis rate of human red blood cells is 0%, showing no hemolytic activity. "Biochem Biophys Res Commun. 2005 May 13;330(3):921-7. PubMed|||Biochem Biophys Res Commun. 2005 May 13;330(3):921-927.||Ref.15809084|||Biochem Biophys Res Commun . 2005 May 13;330(3):921-7. doi: 10.1016/j.bbrc.2005.03.057.|||Biochem Biophys Res Commun. 2005 May 13;330(3):921-927.|||Biochem Biophys Res Commun. 2005 May 13;330(3):921-7. PubMed" 47 FPDB03049 AP02353|||Vasostatin-1|||DRAMP02875|||AP02353|||AP02353 LPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQ Anti-Gram-positive bacteria M. luteus, activity value is MIC = 2 uM||Anti-B. megaterium, activity value is MIC = 0.2 uM||Anti-T. mentagrophytes, activity value is MIC = 1||Anti-and C. albicans, activity value is MIC = 10 uM||Anti-M.luteus, activity value is MIC = 2 uM||Anti-B.megaterium, activity value is MIC = 0.2 uM||Anti-N.crassa, activity value is MIC = 3 uM||Anti-A.fumigatus, activity value is MIC = 5 uM||Anti-A. brassicicola, activity value is MIC = 3 uM||Anti-N.hematococca, activity value is MIC = 1 uM||Anti-F.culmorum, activity value is MIC = 1 uM||Anti-F.oxyporum, activity value is MIC = 10 uM||Anti-S.cerevisiae, activity value is MIC = 10 uM||Anti-C.albicans, activity value is MIC = 10 uM||Anti-Micrococcus luteus, activity value is MIC = 2 uM||Anti-Bacillus megaterium, activity value is MIC = 0.2 uM||Anti-Aspergillus fumigatus, activity value is MIC = 5 uM||Anti-Alternaria brassicicola, activity value is MIC = 3 uM||Anti-Nectria haematococca, activity value is MIC = 1 uM||Anti-Fusarium culmorum, activity value is MIC = 1 uM||Anti-F. oxyporum, activity value is MIC = 10 uM||Anti-Saccharomyces cerevisiae, activity value is MIC = 10 uM||Anti-Candida albicans, activity value is MIC = 10 uM||Anti-Gram+||Antifungal||candidacidal Bos taurus [Bovine]|||Bos taurus (Bovine)|||bovine chromaffin granules, Bos taurus|||bovine chromaffin granules, Bos taurus Helix bovine chromaffin granules, Bos taurus "J Biol Chem. 2000 Apr 14;275(15):10745-53.PubMed||Lugardon K et al., 2001|||10753865|||J Biol Chem. 2000 Apr 14;275(15):10745-10753.|||J Biol Chem . 2000 Apr 14;275(15):10745-53. doi: 10.1074/jbc.275.15.10745.||Lugardon K et al., 2001|||J Biol Chem. 2000 Apr 14;275(15):10745-53.PubMed" 76 FPDB03050 AP02354 KINNPVSCLRKGGRCWNRCIGNTRQIGSCGVPFLKCCKRK synthetic mBD-3 inhibited the growth of E. coli||P. aeruginosa||S. aureus||and C. albicans at concentrations from 25 to 50 ug/ml .||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal epithelia, respiratory system and other mucosal surfaces, mouse, Mus musculus|||epithelia, respiratory system and other mucosal surfaces, mouse, Mus musculus Bridge epithelia, respiratory system and other mucosal surfaces, mouse, Mus musculus "Infect Immun. 1999 Jul;67(7):3542-7.PubMed||Burd RS et al 2002|||Infect Immun . 1999 Jul;67(7):3542-7. doi: 10.1128/IAI.67.7.3542-3547.1999.||Burd RS et al 2002|||Infect Immun. 1999 Jul;67(7):3542-7.PubMed" 40 FPDB03051 AP02355|||CAMPSQ14|||CAMPSQ16272|||DRAMP03033|||Mastoparan-like peptide 12a|||AP02355|||AP02355 INWKGIAAMAKKLL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-E. coli ATCC 25922, activity value is MIC = 7.5 ug/ml||Anti-S. aureus ATCC 2592, activity value is MIC = 3.7 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 3.7 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 7.5 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 3.7 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3.7 ug/ml||Antibacterial Vespa magnifica [Hornet]|||Wasp [Wasp]|||Vespa magnifica (Hornet)|||Vespa magnifica [Hornet]|||venom, the wasp, Vespa magnifica (Smith) or Vespa xanthoptera, Asia|||venom, the wasp, Vespa magnifica (Smith) or Vespa xanthoptera, Asia Helix venom, the wasp, Vespa magnifica (Smith) or Vespa xanthoptera "Biopolymers. 1986;25 Suppl:S115-21.PubMed|||16330062|||35425831|||Toxicon. 2006 Feb;47(2):249-253.||Ref.17046111|||16330062|||Biopolymers . 1986:25 Suppl:S115-21.|||Biopolymers. 1986;25 Suppl:S115-21.PubMed" 14 FPDB03052 AP02356|||AamAPI-1|||DRAMP03706|||AamAPI-1|||AP02356|||AP02356 FLFSLIPHAIGGLISAFK Anti-S. aureus, activity value is MIC = 20 uM||Anti-and poorly active against E. coli, activity value is MIC = 150 uM||Anti-S. aureus NCTC 10788, activity value is MIC = 20 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 150 uM||Anti-Candida albicans NCPF 1467, activity value is MIC = 64 uM||Anti-Staphylococcus aureus, activity value is MIC = 20 uM||Anti-Escherichia coli, activity value is MIC = 150 uM||Anti-Gram+||Antifungal||candidacidal||Hemolytic Androctonus amoreuxi [African scorpion]|||Androctonus amoreuxi (African fattail scorpion)|||venom, the North African scorpion, Androctonus amoreuxi|||venom, the North African scorpion, Androctonus amoreuxi N/A "venom, the North African scorpion, Androctonus amoreuxi||At a concentration of 120 uM, AamAP1 achieves a 100% hemolysis rate within 2 h.|||Horse RBCs( 64.9 % hemolysis at 120 uM After 1 h)|||The document explicitly provides hemolytic data for three antimicrobial peptides (AamAP1, AamAP2, and the mutant AamAP-S1) in the venom of the North African scorpion (Androctonus amoreuxi). The core results are as follows (tested on horse red blood cells, incubation time 120 minutes, positive control 2% Triton X-100): 1. Hemolysis rates corresponding to peptide concentrations: • AamAP1: 100% hemolysis at 120 µM, 44.3% at 100 µM, 8.4% at 60 µM; • AamAP2: 75% hemolysis at 120 µM, 25% at 64 µM, 14% at 48 µM; • AamAP-S1 (His⁸→Lys mutant): hemolysis rate approximately 3% at all tested concentrations (5 µM, 3 µM, etc.), no significant hemolysis. 2. Hemolysis rates corresponding to antimicrobial MIC concentrations: • Against Staphylococcus aureus: AamAP1 (20 µM) hemolysis ≈0%, AamAP2 (48 µM) hemolysis 14%, AamAP-S1 (3 µM) hemolysis ≈3%; • Against Escherichia coli: AamAP1 (150 µM) hemolysis 100%, AamAP2 (120 µM) hemolysis 75%, AamAP-S1 (5 µM) hemolysis ≈3%; • Against Candida albicans: AamAP1 (64 µM) hemolysis 12.95%, AamAP2 (64 µM) hemolysis 36%, AamAP-S1 (5 µM) hemolysis ≈3%.|||Horse RBCs( 64.9 % hemolysis at 120 uM After 1 h)|||When interacting with red blood cells, at concentrations identical to the MICs determined against Staphylococcus aureus, these peptides caused hemolysis after 2 hours of incubation with red blood cells of approximately 0% (AAMAP1), 30% (AAMAP2), and 3% (AAMAP-S1). Similarly, at concentrations equal to the minimum inhibitory concentration for red blood cells, the hemolysis rates for AAMP1, AAMP2, and AAMP-S1 were measured as 100%, 75%, and approximately 3%, respectively. Finally, when used at concentrations equal to their respective MICs for Candida albicans, the percentage of hemolysis for each peptide was 12.95%, 36%, and approximately 3%, respectively.|||When tested against erythrocytes, at a concentration equal to their determined respective MICs for S. aureus, the peptides caused hemolysis of ∼0% (AamAP1), 30% (AamAP2) and 3% (AamAP-S1), after incubation with the red blood cells, for 2 h. Similarly, when tested against the erythrocytes, at a concentration equal to their MICs for E. coli, the percentage hemolysis values deter mined for AamP1, AamP2 and AamP-S1, were 100%, 75% and ∼3%, respectively. Finally, when used at a concentration equal to their respective MICs for C. albicans, percentage hemolysis values of 12.95%, 36% and ∼3%, were obtained for each peptide (Table 2)." "Peptides. 2012 Jun;35(2):291-9. PubMed|||22484288|||Peptides. 2012 Jun;35(2):291-299.|||22484288|||Peptides . 2012 Jun;35(2):291-9. doi: 10.1016/j.peptides.2012.03.016. Epub 2012 Mar 28.|||Peptides. 2012 Jun;35(2):291-9. PubMed" 18 FPDB03053 AP02357 FLFSLIPSAISGLISAF Anti-S. aureus, activity value is MIC = 48 uM||Anti-and poorly active against E.coli, activity value is MIC = 120 uM||Anti-Gram+||Antifungal||candidacidal||Hemolytic venom, the North African scorpion, Androctonus amoreuxi|||venom, the North African scorpion, Androctonus amoreuxi N/A venom, the North African scorpion, Androctonus amoreuxi||Under the same conditions, the hemolysis rate of AamAP2 is 75%.|||When interacting with red blood cells, at concentrations identical to the MICs determined against Staphylococcus aureus, these peptides caused hemolysis after 2 hours of incubation with red blood cells of approximately 0% (AAMAP1), 30% (AAMAP2), and 3% (AAMAP-S1). Similarly, at concentrations equal to the minimum inhibitory concentration for red blood cells, the hemolysis rates for AAMP1, AAMP2, and AAMP-S1 were measured as 100%, 75%, and approximately 3%, respectively. Finally, when used at concentrations equal to their respective MICs for Candida albicans, the percentage of hemolysis for each peptide was 12.95%, 36%, and approximately 3%, respectively.|||When tested against erythrocytes, at a concentration equal to their determined respective MICs for S. aureus, the peptides caused hemolysis of ∼0% (AamAP1), 30% (AamAP2) and 3% (AamAP-S1), after incubation with the red blood cells, for 2 h. Similarly, when tested against the erythrocytes, at a concentration equal to their MICs for E. coli, the percentage hemolysis values deter mined for AamP1, AamP2 and AamP-S1, were 100%, 75% and ∼3%, respectively. Finally, when used at a concentration equal to their respective MICs for C. albicans, percentage hemolysis values of 12.95%, 36% and ∼3%, were obtained for each peptide (Table 2). "Peptides. 2012 Jun;35(2):291-9. PubMed|||Peptides . 2012 Jun;35(2):291-9. doi: 10.1016/j.peptides.2012.03.016. Epub 2012 Mar 28.|||Peptides. 2012 Jun;35(2):291-9. PubMed" 17 FPDB03058 AP02362|||CAMPSQ20067|||Mastoparan-VT2|||AP02362|||AP02362 NLKAIAALAKKLL Anti-Gram-positive S. aureus ATCC25923, activity value is MIC = 5 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 5 uM||Anti-S. aureus IS 10#, activity value is MIC = 10 uM||Anti-S. aureus IS 37#, activity value is MIC = 10 uM||Anti-negative E. coli ATCC25922, activity value is MIC = 20 uM||Anti-E. cloacae ATCC13047, activity value is MIC = 10 uM||Anti-K. pneumoniae ATCC700603, activity value is MIC = 20 uM||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 20 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 40 uM||Anti-B. dysenteriae, activity value is MIC = 20 uM||Anti-E. coli IS 37#, activity value is MIC = 5 uM||Anti-E. coli IS 117#, activity value is MIC = 20 uM||Anti-E. coli IS 218#, activity value is MIC = 10 uM||Anti-P. aeruginosa IS 350#, activity value is MIC = 10 uM||Anti-K. pneumoniae IS 59#, activity value is MIC = 10 uM||Anti-C. albicans ATCC2002, activity value is MIC = 10 uM||Anti-C. albicans ATCC90028, activity value is MIC = 10 uM||Anti-and C. parapsilosis ATCC22019, activity value is MIC = 40 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 5 ug/ml||Anti-Staphylococcus aureus 37, activity value is MIC = 10 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 20 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 10 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 20 ug/ml||Anti-Pseudomonas aeruginosa CMCCB 1010, activity value is MIC = 20 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 40 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 20 ug/ml||Anti-Escherichia coli 37, activity value is MIC = 5 ug/ml||Anti-Escherichia coli 117, activity value is MIC = 20 ug/ml||Anti-Escherichia coli 218, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 10 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 10 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 10 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 10 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 40 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Vespa mandarinia|||Vespa mandarinia|||venom gland, the social wasp, Vespa tropica, Southeastern Asia|||venom gland, the social wasp, Vespa tropica, Southeastern Asia N/A venom gland, the social wasp, Vespa tropica||It has extremely weak hemolytic activity against human red blood cells, showing almost no obvious hemolytic effect.|||Human erythrocytes (- at NA|||Human erythrocytes (- at NA|||At a concentration of 100 ug/ml, only mastoparan-VT3 showed 25.04 5.12% (n = 3) hemolytic activity; all other AMPs examined in this study exhibited little hemolytic activity against washed human erythrocytes. "Toxicon. 2013 Nov;74:151-7. PubMed|||24012601|||24012601|||Toxicon . 2013 Nov:74:151-7. doi: 10.1016/j.toxicon.2013.08.056. Epub 2013 Sep 3.|||Toxicon. 2013 Nov;74:151-7. PubMed" 13 FPDB03059 AP02363|||CAMPSQ20068|||Mastoparan-VT3|||AP02363|||AP02363 INLKAITALAKKLL Anti-Gram-positive S. aureus ATCC25923, activity value is MIC = 10 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 5 uM||Anti-S. aureus IS 10#, activity value is MIC = 2.5 uM||Anti-S. aureus IS 37#, activity value is MIC = 5 uM||Anti-negative E.coli ATCC25922, activity value is MIC > 160 uM||Anti-E. cloacae ATCC13047, activity value is MIC = 5 uM||Anti-K. pneumoniae ATCC700603, activity value is MIC = 20 uM||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 10 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 80 uM||Anti-B. dysenteriae, activity value is MIC = 10 uM||Anti-E.coli IS 37#, activity value is MIC > 160 uM||Anti-E.coli IS 117#, activity value is MIC > 160 uM||Anti-E.coli IS 218#, activity value is MIC > 160 uM||Anti-P. aeruginosa IS 350#, activity value is MIC = 10 uM||Anti-K. pneumoniae IS 59#, activity value is MIC = 20 uM||Anti-C. albicans ATCC2002, activity value is MIC = 5 uM||Anti-C. albicans ATCC90028, activity value is MIC = 10 uM||Anti-and C. parapsilosis ATCC22019, activity value is MIC = 2.5 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 5 ug/ml||Anti-Staphylococcus aureus 10, activity value is MIC = 2.5 ug/ml||Anti-Staphylococcus aureus 37, activity value is MIC = 5 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 5 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 40 ug/ml||Anti-Pseudomonas aeruginosa CMCCB 1010, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 80 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 10 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 20 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 5 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 10 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 2.5 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Vespa tropica|||Vespa tropica|||venom gland, the social wasp, Vespa tropica, Southeastern Asia|||venom gland, the social wasp, Vespa tropica, Southeastern Asia N/A venom gland, the social wasp, Vespa tropica||At a concentration of 100 ug/ml, mastoparan-VT3 exhibits a hemolytic activity of 25.0±5.12% (n=3).|||Human erythrocytes (25% Hemolysis at 100 ug/ml|||Human erythrocytes (25% Hemolysis at 100 ug/ml|||At a concentration of 100 ug/ml, only mastoparan-VT3 showed 25.04 5.12% (n = 3) hemolytic activity; all other AMPs examined in this study exhibited little hemolytic activity against washed human erythrocytes. "Toxicon. 2013 Nov;74:151-7. PubMed|||24012601|||24012601|||Toxicon . 2013 Nov:74:151-7. doi: 10.1016/j.toxicon.2013.08.056. Epub 2013 Sep 3.|||Toxicon. 2013 Nov;74:151-7. PubMed" 14 FPDB03060 AP02364|||CAMPSQ20069|||Mastoparan-VT4|||AP02364|||AP02364 INLKAIAPLAKKLL Anti-Gram-positive S. aureus ATCC25923, activity value is MIC = 80 uM||Anti-E.faecalis ATCC29212, activity value is MIC > 160 uM||Anti-S. aureus IS 10#, activity value is MIC = 40 uM||Anti-S. aureus IS 37#, activity value is MIC = 80 uM||Anti-negative E.coli ATCC25922, activity value is MIC > 160 uM||Anti-E. cloacae ATCC13047, activity value is MIC = 40 uM||Anti-K. pneumoniae ATCC700603, activity value is MIC = 20 uM||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 10 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 uM||Anti-B. dysenteriae, activity value is MIC = 10 uM||Anti-E.coli IS 37#, activity value is MIC > 160 uM||Anti-E. coli IS 117#, activity value is MIC = 80 uM||Anti-E. coli IS 218#, activity value is MIC = 80 uM||Anti-P. aeruginosa IS 350#, activity value is MIC = 80 uM||Anti-K.pneumoniae IS 59#, activity value is MIC > 160 uM||Anti-C.albicans ATCC2002, activity value is MIC > 160 uM||Anti-C. albicans ATCC90028, activity value is MIC = 20 uM||Anti-and C. parapsilosis ATCC22019, activity value is MIC = 20 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 80 ug/ml||Anti-Staphylococcus aureus 10, activity value is MIC = 40 ug/ml||Anti-Staphylococcus aureus 37, activity value is MIC = 80 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 40 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 20 ug/ml||Anti-Pseudomonas aeruginosa CMCCB 1010, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 10 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 10 ug/ml||Anti-Escherichia coli 117, activity value is MIC = 80 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 20 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 20 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 80 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Vespa tropica|||Vespa tropica|||venom gland, the social wasp, Vespa tropica, Southeastern Asia|||venom gland, the social wasp, Vespa tropica, Southeastern Asia N/A venom gland, the social wasp, Vespa tropica||It has extremely weak hemolytic activity against human red blood cells, showing almost no obvious hemolytic effect.|||Human erythrocytes (- at NA|||Human erythrocytes (- at NA|||At a concentration of 100 ug/ml, only mastoparan-VT3 showed 25.04 5.12% (n =3) hemolytic activity; all other AMPs examined in this study exhibited little hemolytic activity against washed human erythrocytes. "Toxicon. 2013 Nov;74:151-7. PubMed|||24012601|||24012601|||Toxicon . 2013 Nov:74:151-7. doi: 10.1016/j.toxicon.2013.08.056. Epub 2013 Sep 3.|||Toxicon. 2013 Nov;74:151-7. PubMed" 14 FPDB03061 AP02365 VIVKAIATLSKKLL Anti-Gram-positive S.aureus ATCC25923, activity value is MIC > 160 uM||Anti-E.faecalis ATCC29212, activity value is MIC > 160 uM||Anti-S.aureus IS 10#, activity value is MIC > 160 uM||Anti-S.aureus IS 37#, activity value is MIC > 160 uM||Anti-negative E.coli ATCC25922, activity value is MIC > 160 uM||Anti-E. cloacae ATCC13047, activity value is MIC = 80 uM||Anti-K. pneumoniae ATCC700603, activity value is MIC = 80 uM||Anti-B.pyocyaneus CMCCB1010, activity value is MIC > 160 uM||Anti-P.aeruginosa ATCC27853, activity value is MIC > 160 uM||Anti-B.dysenteriae, activity value is MIC > 160 uM||Anti-E.coli IS 37#, activity value is MIC > 160 uM||Anti-E.coli IS 117#, activity value is MIC > 160 uM||Anti-E.coli IS 218#, activity value is MIC > 160 uM||Anti-P.aeruginosa IS 350#, activity value is MIC > 160 uM||Anti-K.pneumoniae IS 59#, activity value is MIC > 160 uM||Anti-C.albicans ATCC2002, activity value is MIC > 160 uM||Anti-C. albicans ATCC90028, activity value is MIC = 40 uM||Anti-and C.parapsilosis ATCC22019, activity value is MIC > 160 uM||Anti-Gram-||Antifungal||candidacidal venom gland, the social wasp, Vespa tropica, Southeastern Asia|||venom gland, the social wasp, Vespa tropica, Southeastern Asia N/A venom gland, the social wasp, Vespa tropica||It has extremely weak hemolytic activity against human red blood cells, showing almost no obvious hemolytic effect.|||At a concentration of 100 ug/ml, only mastoparan-VT3 showed 25.04 5.12% (n = 3) hemolytic activity; all other AMPs examined in this study exhibited little hemolytic activity against washed human erythrocytes. "Toxicon. 2013 Nov;74:151-7. PubMed|||Toxicon . 2013 Nov:74:151-7. doi: 10.1016/j.toxicon.2013.08.056. Epub 2013 Sep 3.|||Toxicon. 2013 Nov;74:151-7. PubMed" 14 FPDB03062 AP02366|||CAMPSQ20070|||Mastoparan-VT6|||AP02366|||AP02366 INLKAIAALVKKLL Anti-Gram-positive S. aureus ATCC25923, activity value is MIC = 20 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 80 uM||Anti-S. aureus IS 10#, activity value is MIC = 80 uM||Anti-S. aureus IS 37#, activity value is MIC = 20 uM||Anti-negative E.coli ATCC25922, activity value is MIC > 160 uM||Anti-E. cloacae ATCC13047, activity value is MIC = 80 uM||Anti-K. pneumoniae ATCC700603, activity value is MIC = 40 uM||Anti-B pyocyaneus CMCCB1010, activity value is MIC > 160 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 40 uM||Anti-B. dysenteriae, activity value is MIC = 20 uM||Anti-E. coli IS 37#, activity value is MIC = 40 uM||Anti-E.coli IS 117#, activity value is MIC > 160 uM||Anti-E. coli IS 218#, activity value is MIC = 80 uM||Anti-P. aeruginosa IS 350#, activity value is MIC = 40 uM||Anti-K.pneumoniae IS 59#, activity value is MIC > 160 uM||Anti-C. albicans ATCC2002, activity value is MIC = 80 uM||Anti-C. albicans ATCC90028, activity value is MIC = 80 uM||Anti-and C. parapsilosis ATCC22019, activity value is MIC = 40 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 20 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 80 ug/ml||Anti-Staphylococcus aureus 10, activity value is MIC = 80 ug/ml||Anti-Staphylococcus aureus 37, activity value is MIC = 20 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 80 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 40 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 40 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 20 ug/ml||Anti-Escherichia coli 37, activity value is MIC = 40 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 80 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 80 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 40 ug/ml||Anti-Escherichia coli 218, activity value is MIC = 80 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 40 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Vespa tropica|||Vespa tropica|||venom gland, the social wasp, Vespa tropica, Southeastern Asia|||venom gland, the social wasp, Vespa tropica, Southeastern Asia N/A venom gland, the social wasp, Vespa tropica||It has extremely weak hemolytic activity against human red blood cells, showing almost no obvious hemolytic effect.|||Human erythrocytes (- at NA|||Human erythrocytes (- at NA|||At a concentration of 100 ug/ml, only mastoparan-VT3 showed 25.04 5.12% (n = 3) hemolytic activity; all other AMPs examined in this study exhibited little hemolytic activity against washed human erythrocytes. "Toxicon. 2013 Nov;74:151-7. PubMed|||24012601|||24012601|||Toxicon . 2013 Nov:74:151-7. doi: 10.1016/j.toxicon.2013.08.056. Epub 2013 Sep 3.|||Toxicon. 2013 Nov;74:151-7. PubMed" 14 FPDB03063 AP02367|||CAMPSQ20071|||Mastoparan-VT7|||AP02367|||AP02367 INLKAIAALARNY Anti-Gram-positive S. aureus ATCC25923, activity value is MIC = 10 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 5 uM||Anti-S. aureus IS 10#, activity value is MIC = 40 uM||Anti-S. aureus IS 37#, activity value is MIC = 10 uM||Anti-negative E.coli ATCC25922, activity value is MIC > 160 uM||Anti-E.cloacae ATCC13047, activity value is MIC > 160 uM||Anti-K. pneumoniae ATCC700603, activity value is MIC = 80 uM||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 80 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 80 uM||Anti-B.dysenteriae, activity value is MIC > 160 uM||Anti-E. coli IS 37#, activity value is MIC = 80 uM||Anti-E. coli IS 117#, activity value is MIC = 40 uM||Anti-E. coli IS 218#, activity value is MIC = 40 uM||Anti-P. aeruginosa IS 350#, activity value is MIC = 10 uM||Anti-K.pneumoniae IS 59#, activity value is MIC > 160 uM||Anti-C. albicans ATCC2002, activity value is MIC = 80 uM||Anti-C. albicans ATCC90028, activity value is MIC = 20 uM||Anti-and C.parapsilosis ATCC22019, activity value is MIC > 160 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 5 ug/ml||Anti-Staphylococcus aureus 10, activity value is MIC = 40 ug/ml||Anti-Staphylococcus aureus 37, activity value is MIC = 10 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 80 ug/ml||Anti-Pseudomonas aeruginosa CMCCB 1010, activity value is MIC = 80 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 80 ug/ml||Anti-Escherichia coli 37, activity value is MIC = 80 ug/ml||Anti-Escherichia coli 117, activity value is MIC = 40 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 10 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 80 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 20 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Vespa tropica|||Vespa tropica|||venom gland, the social wasp, Vespa tropica, Southeastern Asia|||venom gland, the social wasp, Vespa tropica, Southeastern Asia N/A venom gland, the social wasp, Vespa tropica||It has extremely weak hemolytic activity against human red blood cells, showing almost no obvious hemolytic effect.|||Human erythrocytes (- at NA|||Human erythrocytes (- at NA|||At a concentration of 100 ug/ml, only mastoparan-VT3 showed 25.04 5.12% (n = 3) hemolytic activity; all other AMPs examined in this study exhibited little hemolytic activity against washed human erythrocytes. "Toxicon. 2013 Nov;74:151-7. PubMed|||24012601|||24012601|||Toxicon . 2013 Nov:74:151-7. doi: 10.1016/j.toxicon.2013.08.056. Epub 2013 Sep 3.|||Toxicon. 2013 Nov;74:151-7. PubMed" 13 FPDB03064 AP02368|||DRAMP18653|||Cm-p5|||AP02368|||DRAMP18653 SRSELIVHQRLF Anti-C. albicans 01U or 38 U, activity value is MIC = 10 ug/ml||Anti-C. parapsilosis, activity value is MIC = 32 ug/ml||Anti-C. neoformans L26, activity value is MIC = 64 ug/ml||Anti-C. neoformans L30, activity value is MIC = 64 ug/ml||Anti-T.mentagrophytes, activity value is MIC = 128 ug/ml||Anti-and T. rubrum, activity value is MIC = 10 ug/ml||Anti-Candida albicans, activity value is MIC = 10 ug/ml||Anti-Candida parapsilosis, activity value is MIC = 32 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 64 ug/ml||Anti-Trichophyton mentagrophytes, activity value is MIC = 128 ug/ml||Anti-Trichophyton rubrum, activity value is MIC = 10 ug/ml||Antifungal||Anti-Gram+ & Gram-||candidacidal Synthetic construct|||Cenchritis muricatus [Beaded periwinkle]|||amino acid substitution, molluscs, animal-derived, natural derivative|||Synthetic construct|||amino acid substitution, molluscs, animal-derived, natural derivative Helix amino acid substitution, molluscs, animal-derived, natural derivative||Cm-p5 exhibits no hemolytic activity against human red blood cells at a concentration of 400 ug/ml.|||No hemolysis information or data found in the reference(s) presented in this entry "FASEB J. 2015 Aug;29(8):3315-25. doi: 10.1096/fj.14-269860. PubMed|||FASEB J. 2015 Aug;29(8):3315-25.||Ref.25921828|||25921828|||FASEB J . 2015 Aug;29(8):3315-25. doi: 10.1096/fj.14-269860. Epub 2015 Apr 28.|||FASEB J. 2015 Aug;29(8):3315-25.||Ref.25921828|||FASEB J. 2015 Aug;29(8):3315-25. doi: 10.1096/fj.14-269860. PubMed" 12 FPDB03065 AP02369|||VCP-VT2|||AP02369 FLPIIGKLLSG Anti-Gram-positive S. aureus ATCC25923, activity value is MIC = 2.5 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 20 uM||Anti-S. aureus IS 10#, activity value is MIC = 10 uM||Anti-S. aureus IS 37#, activity value is MIC = 5 uM||Anti-negative E. coli ATCC25922, activity value is MIC = 5 uM||Anti-E. cloacae ATCC13047, activity value is MIC = 2.5 uM||Anti-K. pneumoniae ATCC700603, activity value is MIC = 10 uM||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 20 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 5 uM||Anti-B. dysenteriae, activity value is MIC = 5 uM||Anti-E. coli IS 37#, activity value is MIC = 20 uM||Anti-E. coli IS 117#, activity value is MIC = 5 uM||Anti-E. coli IS 218#, activity value is MIC = 20 uM||Anti-P. aeruginosa IS 350#, activity value is MIC = 10 uM||Anti-K. pneumoniae IS 59#, activity value is MIC = 80 uM||Anti-C. albicans ATCC2002, activity value is MIC = 10 uM||Anti-C. albicans ATCC90028, activity value is MIC = 10 uM||Anti-and C. parapsilosis ATCC22019, activity value is MIC = 2.5 uM||Anti-Candida albicans, activity value is MIC > 100 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal Vespa tropica|||venom gland, the social wasp, Vespa tropica, Southeastern Asia|||venom gland, the social wasp, Vespa tropica, Southeastern Asia N/A venom gland, the social wasp, Vespa tropica|||At a concentration of 100 ug/ml, only mastoparan-VT3 showed 25.04 5.12% (n = 3) hemolytic activity; all other AMPs examined in this study exhibited little hemolytic activity against washed human erythrocytes. "Toxicon. 2013 Nov;74:151-7. PubMed|||https://pubmed.ncbi.nlm.nih.gov/28105725|||Toxicon . 2013 Nov:74:151-7. doi: 10.1016/j.toxicon.2013.08.056. Epub 2013 Sep 3.|||Toxicon. 2013 Nov;74:151-7. PubMed" 11 FPDB03092 AP02406|||3 x Mytichitin-A|||AP02406 TVKCGMNGKMPCKHGAFYTDTCDKNVFYRCVWGRPVKKACGRGLVWNPRGFCDYA Anti-Gram-negative bacteria E. coli, activity value is MIC = 25||Anti-V. harveyi, activity value is MIC = 25||Anti-V-parahaemolyticus, activity value is MIC > 50 uM||Anti-P-aeruginosa, activity value is MIC > 50 uM||Anti-positive B. subtilis, activity value is MIC = 1.2||Anti-S. aureus, activity value is MIC = 2.5||Anti-S. luteus, activity value is MIC = 1.2||Anti-and fungi C. albicans, activity value is MIC = 6.7||Anti-Listeria monocytogenes, activity value is MIC = 80 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 60 ug/ml||Anti-Escherichia coli O157, activity value is MIC = 60 ug/ml||Anti-Salmonella enteriditis, activity value is MIC = 80 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Synthetic construct|||Mytilus coruscus Bridge Mytilus coruscus ACTA HYDROBIOLOGICA SINICA 2014 May; 38(3):563-570. doi: 10.7541/2014.79 (In Chinese).|||29066128|||ACTA HYDROBIOLOGICA SINICA 2014 May; 38(3):563-570. doi: 10.7541/2014.79 (In Chinese). 55 FPDB03097 AP02411|||Balteatide|||Balteatide|||AP02411|||AP02411 LRPAILVRIK Anti-Gram-||Antifungal||candidacidal||Anti-Escherichia coli NCTC 10418, activity value is MIC = 128 ug/ml||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC > 512 ug/ml||Anti-Candida albicans NCPF 1467, activity value is MIC = 32 ug/ml Synthetic construct|||Phyllomedusa baltea|||the skin secretion, wild Peruvian purple-sided leaf frogs, Phyllomedusa baltea; South America|||the skin secretion, wild Peruvian purple-sided leaf frogs, Phyllomedusa baltea; South America N/A the skin secretion, wild Peruvian purple-sided leaf frogs, Phyllomedusa baltea; South America|||Human erythrocytes (0% Hemolysis at 128 ug/ml Sci World J 2014; 2014, article ID 176214. Online version|||25054164|||https://pubmed.ncbi.nlm.nih.gov/25054164|||Sci World J 2014; 2014, article ID 176214. Online version|||Sci World J 2014; 2014, article ID 176214. Online version 10 FPDB03105 AP02420|||Hylaranin-L1|||Hylaranin-L1|||AP02420|||AP02420 GVLSAFKNALPGIMKIIV Anti-E. coli, activity value is MIC = 34 uM||Anti-S. aureus, activity value is MIC = 4.3 uM||Anti-and C. albicans, activity value is MIC = 4||Anti-Escherichia coli NCTC 10418, activity value is MIC = 64 ug/ml||Anti-Candida albicans NCPF 1467, activity value is MIC = 16 ug/ml||Anti-Escherichia coli NCTC 10418, activity value is MBC = 128 ug/ml||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 32 ug/ml||Anti-Candida albicans NCPF 1467, activity value is MBC = 32 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Hylarana latouchii|||skin secretion, the oriental broad-folded frog, Brown Wood Frog, Hylarana latouchii, Asia.|||skin secretion, the oriental broad-folded frog, Brown Wood Frog, Hylarana latouchii, Asia. N/A skin secretion, the oriental broad-folded frog, Brown Wood Frog, Hylarana latouchii, Asia.|||Horse erythrocytes (3% Hemolysis at 8 ug/ml|||Horse erythrocytes (3% Hemolysis at 8 ug/ml "Amino Acids. 2014 Apr;46(4):901-9. doi: 10.1007/s00726-013-1655-1. PubMed|||24378871|||24378871|||Amino Acids . 2014 Apr;46(4):901-9. doi: 10.1007/s00726-013-1655-1. Epub 2013 Dec 31.|||Amino Acids. 2014 Apr;46(4):901-9. doi: 10.1007/s00726-013-1655-1. PubMed" 18 FPDB03106 AP02421 GVLSVIKNALPGIMRF Anti-E. coli, activity value is MIC = 34 uM||Anti-S. aureus, activity value is MIC = 4.3 uM||Anti-and C. albicans, activity value is MIC = 4||Anti-Gram+ & Gram-||Antifungal||candidacidal skin secretion, the oriental broad-folded frog, Brown Wood Frog, Hylarana latouchii, Asia.|||skin secretion, the oriental broad-folded frog, Brown Wood Frog, Hylarana latouchii, Asia. N/A skin secretion, the oriental broad-folded frog, Brown Wood Frog, Hylarana latouchii, Asia. "Amino Acids. 2014 Apr;46(4):901-9. doi: 10.1007/s00726-013-1655-1. PubMed|||Amino Acids . 2014 Apr;46(4):901-9. doi: 10.1007/s00726-013-1655-1. Epub 2013 Dec 31.|||Amino Acids. 2014 Apr;46(4):901-9. doi: 10.1007/s00726-013-1655-1. PubMed" 16 FPDB03115 AP02434|||Mytichitin-CB|||AP02434 TVKCGMNGKMPCKHGAFYTDTCDKNVFYRCVWGRPVKKHCGRGLVWNPRGFCDYA Anti-and B. megaterium, activity value is MIC < 5 uM||Anti-C. albicans and M. albican, activity value is MIC = 6.2||Antibacterial||Antifungal ; Escherichia coli CGMCC 1.1583(MIC = >100 uM)||Vibrio Parahaemolyticus||Pseudomonas aeruginosa||Bacillus subtilis||Staphylococcus aureus||Sarcina luteus||B. megtaterium||Candida albicans||Anti-Gram+||Antifungal||candidacidal Mytilus coruscus|||gonad, hemolymph, Mytilus coruscus|||gonad, hemolymph, Mytilus coruscus Bridge gonad, hemolymph, Mytilus coruscus "Fish Shellfish Immunol. 2014 Sep 19. doi: 10.1016/j.fsi.2014.09.019.PubMed|||25245621|||Fish Shellfish Immunol . 2014 Dec;41(2):362-70. doi: 10.1016/j.fsi.2014.09.019. Epub 2014 Sep 22.|||Fish Shellfish Immunol. 2014 Sep 19. doi: 10.1016/j.fsi.2014.09.019.PubMed" 55 FPDB03118 AP02438 AYVLDEPKPIKDLEKSLQHNLVYCRRLVLEYFLKSIFEYH Anti-E. coli ATCC25922, activity value is MIC = 12 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 12 ug/ml||Anti-Streptococcus sp. ATCC55121, activity value is MIC = 24 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal reproductive tract, sheep, Sheep. Ovis aries|||reproductive tract, sheep, Sheep. Ovis aries N/A reproductive tract, sheep, Sheep. Ovis aries||Even at a concentration as high as 192 ug/ml, its hemolysis rate against rabbit red blood cells is only 1.5%.|||SRTAP-40 showed very low hemolytic activity (lysing only 1.5 % rabbit RBC at 192 ug/ml). "Biotechnol Lett. 2015 Feb;37(2):327-32. PubMed|||Biotechnol Lett . 2015 Feb;37(2):327-32. doi: 10.1007/s10529-014-1682-3. Epub 2014 Sep 26.|||Biotechnol Lett. 2015 Feb;37(2):327-32. PubMed" 40 FPDB03128 AP02453|||Scolopendin 1|||DRAMP21259|||AP02453|||DRAMP21259|||AP02453 MDSFQKIEKIGEGTYGVVYKAKDKVSGRLVALKKIRLENESEGVPSTA Anti-E. faecium ATCC 19434, activity value is MIC = 5||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 5 uM||Anti-and T. beigelii KCTC 7707, activity value is MIC = 10||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5||Anti-Enterococcus faecium ATCC 19434, activity value is MIC = 10||Anti-Escherichia coli O-157 ATCC 43895, activity value is MIC = 5||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 5||Anti-Candida albicans ATCC 90028, activity value is MIC = 10||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 10||Anti-Trichosporon beigelii KCTC 7707, activity value is MIC = 20||Anti-##Gram-negative bacteria : Escherichia coli O-157 ATCC 43895, activity value is MIC = 5||Anti-##Fungi : Candida albicans ATCC 90028, activity value is MIC = 10||Anti-Gram+ & Gram-||Antifungal||candidacidal Scolopendra subspinipes mutilans|||Synthetic construct|||Chinese red-headed centipede Scolopendra subspinipes mutilans, Asia|||Synthetic construct|||Chinese red-headed centipede Scolopendra subspinipes mutilans, Asia N/A "Chinese red-headed centipede Scolopendra subspinipes mutilans, Asia||Next, thehaemolysis assay against human erythrocytes was per-formed. Scolopendin 1 did not induce haemolysis at all thetested concentrations, while melittin induced 13.4% hae-molysis at its MIC (2.5 uM). At 40 uM or more,melittininduced 100.0% haemolysis (Table 2).|||Non-hemolytic against hRBCs|||- scolopendin 1: At all tested concentrations of 1.3 µM, 2.5 µM, 5 µM, 10 µM, 20 µM, 40 µM, and 80 µM, the hemolysis rate was 0%, showing no hemolytic activity. - melittin (positive control): - 1.3 µM: 0% - 2.5 µM: 13.4 ± 7.1% - 5 µM: 36.7 ± 9.5% - 10 µM: 74.0 ± 7.4% - 20 µM: 98.4 ± 2.0% - 40 µM: 100 ± 3.3% - 80 µM: 100 ± 2.3%|||[Ref.25209888] 0% hemolysis at 80 uM against human red blood cells" "Insect Mol Biol. 2014 Dec;23(6):788-99. PubMed|||25209888|||Insect Mol Biol. 2014 Dec;23(6):788-99. doi: 10.1111/imb.12124.||Ref.25209888|||Insect Mol Biol . 2014 Dec;23(6):788-99. doi: 10.1111/imb.12124. Epub 2014 Sep 11.|||Insect Mol Biol. 2014 Dec;23(6):788-99. doi: 10.1111/imb.12124.||Ref.25209888|||Insect Mol Biol. 2014 Dec;23(6):788-99. PubMed" 48 FPDB03130 AP02456|||Cathelicidin-RC1|||Cathelicidin-RC1|||AP02456|||DRAMP31841|||AP02456 KKCKFFCKVKKKIKSIGFQIPIVSIPFK Anti-Gram- E. coli, activity value is MIC = 2.8||Anti-K. peneumoniae, activity value is MIC = 5.7||Anti-K.peneumoniae, activity value is MIC > 200||Anti-K. oxytoca, activity value is MIC = 1.43 uM||Anti-P. mirabilis, activity value is MIC = 5.7 uM||Anti-S. maltophilia, activity value is MIC = 11.4 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 2.9 uM||Anti-S. aureus (3 active, activity value is MIC = 2.9 uM||Anti-3 inactive, activity value is MIC > 200 uM||Anti-E. faecium, activity value is MIC = 2.9 uM||Anti-E. faecalis, activity value is MIC = 22.8 uM||activity value is MIC = 2.9||Anti-Escherichia coli ATCC 25922, activity value is MIC = 4.69 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 9.38 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 18.75 ug/ml||Anti-Escherichia coli, activity value is MIC = 9.38||Anti-Shigella dysenteriae, activity value is MIC = 4.69 ug/ml||Anti-Klebsiella pneumoniae 1, activity value is MIC = 37.5 ug/ml||Anti-Klebsiella pneumoniae 2, activity value is MIC = 18.75 ug/ml||Anti-Klebsiella pneumoniae 5, activity value is MIC > 200 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 75 ug/ml||Anti-Serratia marcescens, activity value is MIC > 200 ug/ml||Anti-Klebsiella oxytoca, activity value is MIC = 4.69 ug/ml||Anti-Proteus vulgaris, activity value is MIC > 200 ug/ml||Anti-Proteus mirabilis, activity value is MIC = 18.75 ug/ml||Anti-Acinetobacter baumannii, activity value is MIC > 200 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 37.5 ug/ml||Anti-Stenotrophomonas maltophilia 2, activity value is MIC = 9.38 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 9.38 ug/ml||Anti-Pseudomonas aeruginosa 1, activity value is MIC = 18.75 ug/ml||Anti-Pseudomonas aeruginosa 2, activity value is MIC = 4.69 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Paratyphi A, activity value is MIC = 37.5 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus 1, activity value is MIC = 4.69||Anti-Staphylococcus aureus 4, activity value is MIC > 200 ug/ml||Anti-Bacillus cereus, activity value is MIC > 200 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 9.38 ug/ml||Anti-Enterococcus faecium, activity value is MIC = 9.38 ug/ml||Anti-Nocardia asteroides, activity value is MIC = 75 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 75 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 9.38 ug/ml||Anti-Candida albicans 1, activity value is MIC = 9.38 ug/ml||Anti-Candida albicans 5, activity value is MIC > 200 ug/ml||Anti-Candida albicans, activity value is MIC = 37.5 ug/ml||Anti-Candida glabrata 1, activity value is MIC = 9.38 ug/ml||Anti-Candida glabrata, activity value is MIC > 200 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC > 200 ug/ml||Anti-Arcyria cinerea, activity value is MIC = 18.75 ug/ml||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal Lithobates catesbeiana|||Lithobates catesbeiana|||the American bullfrog Rana catesbeiana , North America|||the American bullfrog Rana catesbeiana , North America Helix the American bullfrog Rana catesbeiana , North America||Human erythrocytes were used to examine the hemolytic ac-tivity of the peptides identified in this study. As shown in Table 5,different antimicrobial peptides showed distinct hemolytic activity.For example, temporin-TP3, brevinin-1TP4, andbrevinin-1LF1displayed the strongest hemolytic activity among the tested pep-tides. Temporin-TP3 and brevinin-1TP4 showed 100% hemolyticactivity at a concentration of 100000 uM, while brevinin-1LF1 showed100% hemolytic activityat50000 uM. Some peptides devoid of anti-microbial activity, such as taipehensin-1TP1, taipehensin-2TP1,amolopin-p-LF1, amolopin-p-LF1, and amolopin-6-GN1, did notshow any hemolytic activity or showed very low hemolytic activity.|||Human erythrocytes (0% Hemolysis at 100 ug/ml|||Human erythrocytes (0% Hemolysis at 100 ug/ml|||Human erythrocytes:0% Hemolysis=100 ug/ml; 3% Hemolysis=200 ug/ml|||different antimicrobial peptides showed distinct hemolytic activity. For example, temporin-TP3, brevinin-1TP4, and brevinin-1LF1 displayed the strongest hemolytic activity among the tested pep-tides. Temporin-TP3 and brevinin-1TP4 showed 100% hemolytic activity at a concentration of 100 uM,while brevinin-1LF1 showed 100% hemolytic activity at 50 uM. Some peptides devoid of anti microbial activity, such as taipehensin-1TP1, taipehensin-2TP1, amolopin-p-LF1, amolopin-p-LF1, and amolopin-6-GN1, did not show any hemolytic activity or showed very low hemolytic activity. "Biochimie. 2014 Oct;105:192-201. PubMed|||24675879|||24675879|||Biochimie . 2014 Oct:105:192-201. doi: 10.1016/j.biochi.2014.07.013. Epub 2014 Jul 24.|||Cancer Res. 2014 Apr 15;74(8):2144-51.|||Biochimie. 2014 Oct;105:192-201. PubMed" 28 FPDB03136 AP02462|||Brevinin-1TP2|||Brevinin-1TP2|||AP02462|||AP02462 FLPGLIKAAVGIGSTIFCKISKKC Anti-Gram+ S. aureus ATCC 25923, activity value is MIC = 6.3 uM||Anti-E. faecium 091299, activity value is MIC = 100 uM||Anti-E. faecalis 981, activity value is MIC = 3.1 uM||Anti-N. asteroides 201118, activity value is MIC = 3.1 uM||Anti-P.aeruginosa CGMCC 1.50, activity value is MIC > 100 uM||Anti-K. pneumoniae 08040724, activity value is MIC = 100 uM||Anti-E. cloacae CGMCC 1.57, activity value is MIC = 100 uM||Anti-E. coli ATCC 25922, activity value is MIC = 100 uM||Anti-P. faecalis X29, activity value is MIC = 25 uM||Anti-and fungi C. glabrata 090902, activity value is MIC = 6.3 uM||Anti-and C. albicans(ATCC 10231, activity value is MIC = 50 uM||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.3 uM||Anti-Enterococcus faecium 091299, activity value is MIC = 100 uM||Anti-Enterococcus faecalis 981, activity value is MIC = 3.1 uM||Anti-Nocardia asteroides 201118, activity value is MIC = 3.1 uM||Anti-Klebsiella pneumoniae 08040724, activity value is MIC = 100 uM||Anti-Enterobacter cloacae CGMCC 1.57, activity value is MIC = 100 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 100 uM||Anti-Psychrobacter faecalis X29, activity value is MIC = 25 uM||Anti-Candida glabrata 090902, activity value is MIC = 6.3 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 50 uM||Anti-Gram+ & Gram-||candidacidal||Antioxidant||Hemolytic Hylarana taipehensis|||Hylarana taipehensis|||skin secretions, Hylarana taipehensis, China, Asia|||skin secretions, Hylarana taipehensis, China, Asia N/A skin secretions, Hylarana taipehensis, China, Asia|||Human erythrocytes (0% Hemolysis at 6.3 uM|||Human erythrocytes (0% Hemolysis at 6.3 uM|||different antimicrobial peptides showed distinct hemolytic activity. For example, temporin-TP3, brevinin-1TP4, and brevinin-1LF1 displayed the strongest hemolytic activity among the tested pep-tides. Temporin-TP3 and brevinin-1TP4 showed 100% hemolytic activity at a concentration of 100 uM,while brevinin-1LF1 showed 100% hemolytic activity at 50 uM. Some peptides devoid of anti microbial activity, such as taipehensin-1TP1, taipehensin-2TP1, amolopin-p-LF1, amolopin-p-LF1, and amolopin-6-GN1, did not show any hemolytic activity or showed very low hemolytic activity. "Biochimie. 2014 Oct;105:192-201. PubMed|||25066917|||25066917|||Biochimie . 2014 Oct:105:192-201. doi: 10.1016/j.biochi.2014.07.013. Epub 2014 Jul 24.|||Biochimie. 2014 Oct;105:192-201. PubMed" 24 FPDB03138 AP02464 FLPGLIKAAVGIGSTIFCKISRKC Anti-Gram+ S. aureus ATCC 25923, activity value is MIC = 3.1 uM||Anti-E. faecium 091299, activity value is MIC = 100 uM||Anti-E. faecalis 981, activity value is MIC = 3.1 uM||Anti-N. asteroides 201118, activity value is MIC = 3.1 uM||Anti-P.aeruginosa CGMCC 1.50, activity value is MIC > 100 uM||Anti-K. pneumoniae 08040724, activity value is MIC = 100 uM||Anti-E. cloacae CGMCC 1.57, activity value is MIC = 100 uM||Anti-E. coli ATCC 25922, activity value is MIC = 100 uM||Anti-P. faecalis X29, activity value is MIC = 25 uM||Anti-and fungi C. glabrata 090902, activity value is MIC = 3.1 uM||Anti-and C. albicans(ATCC 10231, activity value is MIC = 50 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Hemolytic skin secretions, Hylarana taipehensis, China, Asia|||skin secretions, Hylarana taipehensis, China, Asia N/A skin secretions, Hylarana taipehensis, China, Asia|||different antimicrobial peptides showed distinct hemolytic activity. For example, temporin-TP3, brevinin-1TP4, and brevinin-1LF1 displayed the strongest hemolytic activity among the tested pep-tides. Temporin-TP3 and brevinin-1TP4 showed 100% hemolytic activity at a concentration of 100 uM,while brevinin-1LF1 showed 100% hemolytic activity at 50 uM. Some peptides devoid of anti microbial activity, such as taipehensin-1TP1, taipehensin-2TP1, amolopin-p-LF1, amolopin-p-LF1, and amolopin-6-GN1, did not show any hemolytic activity or showed very low hemolytic activity. "Biochimie. 2014 Oct;105:192-201. PubMed|||Biochimie . 2014 Oct:105:192-201. doi: 10.1016/j.biochi.2014.07.013. Epub 2014 Jul 24.|||Biochimie. 2014 Oct;105:192-201. PubMed" 24 FPDB03154 AP02481|||Magainin-M1|||Magainin-M1|||AP02481|||DRAMP04642|||AP02481 GIGKFLHSAGKFGKAFIGEIMKS Anti-E. coli, activity value is MIC = 1||Anti-S. aureus, activity value is MIC = 50 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25726, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 50 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 25 uM||No MICs found in DRAMP database||Anti-Gram+ & Gram-||candidacidal Xenopus muelleri|||Xenopus muelleri|||Xenopus muelleri, Africa|||Xenopus muelleri, Africa N/A Xenopus muelleri, Africa|||Human erythrocytes (50% Hemolysis at 180 uM|||Human erythrocytes (50% Hemolysis at 180 uM|||Use the LC_(50) value as the average concentration of peptides that cause 50% hemolysis under the two incubation conditions.|||No hemolysis information or data found in the reference(s) presented in this entry|||CPF-MW1 (LC50= 70 uM), CPF-MW2 (LC50= 105 uM), and magainin-M1 (LC50= 180 uM) showed moderately high hemolytic activity against human erythrocytes (Table 1) whereas the hemolytic activities of magainin-MW1, tigerinin-M1 and PGLa-MW1 were very low (LC50> 200 uM). Tigerinin-M1 did not display antimicrobial activity and did not inhibit the activity of elastase at a concentration of 100 uM. "Peptides. 2011 Jul;32(7):1502-8. PubMed|||21664395|||21664395|||Peptides . 2011 Jul;32(7):1502-8. doi: 10.1016/j.peptides.2011.05.025. Epub 2011 Jun 1.|||Peptides. 2011 Jul;32(7):1502-1508.|||Peptides. 2011 Jul;32(7):1502-8. PubMed" 23 FPDB03155 AP02482|||CPF-M1|||CPF-M1|||AP02482|||DRAMP04643|||AP02482 GLGSLLGKAFKFGLKTVGKMMAGAPREQ Anti-E. coli, activity value is MIC = 12.5 uM||Anti-S. aureus, activity value is MIC = 6 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Anti-Escherichia coli ATCC 25726, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 25 uM||No MICs found in DRAMP database||Anti-Gram+ & Gram-||Antifungal||candidacidal Xenopus muelleri|||Xenopus muelleri|||Xenopus muelleri, Africa|||Xenopus muelleri, Africa N/A Xenopus muelleri, Africa|||Use the LC_(50) value as the average concentration of peptides that cause 50% hemolysis under the two incubation conditions.|||No hemolysis information or data found in the reference(s) presented in this entry|||CPF-MW1 (LC50= 70 uM), CPF-MW2 (LC50= 105 uM), and magainin-M1 (LC50= 180 uM) showed moderately high hemolytic activity against human erythrocytes (Table 1) whereas the hemolytic activities of magainin-MW1, tigerinin-M1 and PGLa-MW1 were very low (LC50> 200 uM). Tigerinin-M1 did not display antimicrobial activity and did not inhibit the activity of elastase at a concentration of 100 uM. "Peptides. 2011 Jul;32(7):1502-8. PubMed|||21664395|||21664395|||Peptides . 2011 Jul;32(7):1502-8. doi: 10.1016/j.peptides.2011.05.025. Epub 2011 Jun 1.|||Peptides. 2011 Jul;32(7):1502-1508.|||Peptides. 2011 Jul;32(7):1502-8. PubMed" 28 FPDB03156 AP02483|||DRAMP04626 GIGKFLHSAGKFGKAFLGEVMKS Anti-E. coli, activity value is MIC = 50 uM||Anti-and C. albicans, activity value is MIC = 100 uM||No MICs found in DRAMP database||Anti-Gram-||Antifungal||candidacidal Xenopus muelleri, West Africa|||Xenopus clivii N/A Xenopus muelleri, West Africa|||Use the LC_(50) value as the average concentration of peptides that cause 50% hemolysis under the two incubation conditions.|||No hemolysis information or data found in the reference(s) presented in this entry|||CPF-MW1 (LC50= 70 uM), CPF-MW2 (LC50= 105 uM), and magainin-M1 (LC50= 180 uM) showed moderately high hemolytic activity against human erythrocytes (Table 1) whereas the hemolytic activities of magainin-MW1, tigerinin-M1 and PGLa-MW1 were very low (LC50> 200 uM). Tigerinin-M1 did not display antimicrobial activity and did not inhibit the activity of elastase at a concentration of 100 uM. "Peptides. 2011 Jul;32(7):1502-8. PubMed|||Peptides . 2011 Jul;32(7):1502-8. doi: 10.1016/j.peptides.2011.05.025. Epub 2011 Jun 1.|||Comp Biochem Physiol C Toxicol Pharmacol. 2011 Apr;153(3):350-354.|||Peptides. 2011 Jul;32(7):1502-8. PubMed" 23 FPDB03157 AP02484|||PGLa-MW1|||PGLa-MW1|||AP02484|||DRAMP04644|||AP02484 GMASKAGSVLGKITKIALGAL Anti-E. coli, activity value is MIC = 12.5 uM||Anti-S. aureus, activity value is MIC = 100 uM||Anti-and C. albicans, activity value is MIC = 50 uM||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25726, activity value is MIC = 12.5 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 100 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 50 uM||No MICs found in DRAMP database||Anti-Gram+ & Gram-||candidacidal Synthetic construct|||Xenopus muelleri, West Africa|||Xenopus muelleri N/A Xenopus muelleri, West Africa|||Human erythrocytes (50% Hemolysis at >200 uM|||Human erythrocytes (50% Hemolysis at >200 uM|||Use the LC_(50) value as the average concentration of peptides that cause 50% hemolysis under the two incubation conditions.|||No hemolysis information or data found in the reference(s) presented in this entry|||CPF-MW1 (LC50= 70 uM), CPF-MW2 (LC50= 105 uM), and magainin-M1 (LC50= 180 uM) showed moderately high hemolytic activity against human erythrocytes (Table 1) whereas the hemolytic activities of magainin-MW1, tigerinin-M1 and PGLa-MW1 were very low (LC50> 200 uM). Tigerinin-M1 did not display antimicrobial activity and did not inhibit the activity of elastase at a concentration of 100 uM. "Peptides. 2011 Jul;32(7):1502-8. PubMed|||21664395|||21664395|||Peptides . 2011 Jul;32(7):1502-8. doi: 10.1016/j.peptides.2011.05.025. Epub 2011 Jun 1.|||Peptides. 2011 Jul;32(7):1502-1508.|||Peptides. 2011 Jul;32(7):1502-8. PubMed" 21 FPDB03158 AP02485|||CPF-MW1|||CPF-MW1|||AP02485|||DRAMP04645|||AP02485 GLGSLLGKAFKFGLKTVGKMMGGAPREQ Anti-E. coli, activity value is MIC = 3 uM||Anti-S. aureus, activity value is MIC = 6 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Anti-Escherichia coli ATCC 25726, activity value is MIC = 3 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 25 uM||No MICs found in DRAMP database||Anti-Gram+ & Gram-||Antifungal||candidacidal Xenopus muelleri West|||Xenopus muelleri West|||Xenopus muelleri, West Africa|||Xenopus muelleri|||Xenopus muelleri, West Africa N/A Xenopus muelleri, West Africa|||Human erythrocytes (50% Hemolysis at 70 uM|||Human erythrocytes (50% Hemolysis at 70 uM|||Use the LC_(50) value as the average concentration of peptides that cause 50% hemolysis under the two incubation conditions.|||No hemolysis information or data found in the reference(s) presented in this entry|||CPF-MW1 (LC50= 70 uM), CPF-MW2 (LC50= 105 uM), and magainin-M1 (LC50= 180 uM) showed moderately high hemolytic activity against human erythrocytes (Table 1) whereas the hemolytic activities of magainin-MW1, tigerinin-M1 and PGLa-MW1 were very low (LC50> 200 uM). Tigerinin-M1 did not display antimicrobial activity and did not inhibit the activity of elastase at a concentration of 100 uM. "Peptides. 2011 Jul;32(7):1502-8. PubMed|||21664395|||21664395|||Peptides . 2011 Jul;32(7):1502-8. doi: 10.1016/j.peptides.2011.05.025. Epub 2011 Jun 1.|||Peptides. 2011 Jul;32(7):1502-1508.|||Peptides. 2011 Jul;32(7):1502-8. PubMed" 28 FPDB03160 AP02487|||CAMPSQ21782|||Hylain 1|||AP02487|||AP02487 GILDAIKAFANALG Anti-Gram+ S. aureus, activity value is MIC = 5.5 ug/ml||Anti-B. subtilis, activity value is MIC = 5.5 ug/ml||Anti-B. cereus, activity value is MIC = 11 ug/ml||Anti-E. coli, activity value is MIC = 44 ug/ml||Anti-B. dysenteriae, activity value is MIC = 2.7 ug/ml||Anti-P. aeruginosa, activity value is MIC = 5.5 ug/ml||Anti-and fungus C. albicans, activity value is MIC = 66 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 5.5 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 5.5 ug/ml||Anti-Bacillus cereus, activity value is MIC = 11 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 44 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 2.75 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 5.5 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 66 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Hyla simplex|||Hyla simplex|||skin, Hyla simplex, Guang Xi, China, Asia|||skin, Hyla simplex, Guang Xi, China, Asia N/A skin, Hyla simplex, Guang Xi, China, Asia "J Proteome Res. 2011 Sep 2;10(9):4230-40. PubMed|||21740067|||21740067|||J Proteome Res . 2011 Sep 2;10(9):4230-40. doi: 10.1021/pr200393t. Epub 2011 Aug 9.|||J Proteome Res. 2011 Sep 2;10(9):4230-40. PubMed" 14 FPDB03161 AP02488|||CAMPSQ21783|||Hylain 2|||AP02488|||AP02488 GILDPIKAFAKAAG Anti-Gram+ S. aureus, activity value is MIC = 5.5 ug/ml||Anti-B. subtilis, activity value is MIC = 11 ug/ml||Anti-B. cereus, activity value is MIC = 22 ug/ml||Anti-E. coli, activity value is MIC = 22 ug/ml||Anti-B. dysenteriae, activity value is MIC = 5.5 ug/ml||Anti-P. aeruginosa, activity value is MIC = 11 ug/ml||Anti-and fungus C. albicans, activity value is MIC = 44 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 5.5 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 11 ug/ml||Anti-Bacillus cereus, activity value is MIC = 22 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 22 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 5.5 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 11 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 44 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Hyla simplex|||Hyla simplex|||skin, Hyla simplex, Guang Xi, China, Asia|||skin, Hyla simplex, Guang Xi, China, Asia N/A skin, Hyla simplex, Guang Xi, China, Asia "J Proteome Res. 2011 Sep 2;10(9):4230-40. PubMed|||21740067|||21740067|||J Proteome Res . 2011 Sep 2;10(9):4230-40. doi: 10.1021/pr200393t. Epub 2011 Aug 9.|||J Proteome Res. 2011 Sep 2;10(9):4230-40. PubMed" 14 FPDB03162 AP02489|||CPF-SP1|||CPF-SP1|||AP02489|||AP02489 GFLGPLLKLGLKGVAKVLPHLIPSRQQ Anti-E. coli, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 6 uM||Anti-A. baumannii, activity value is MIC = 12.5 uM||Anti-K. pneumoniae, activity value is MIC = 25 uM||Anti-P. aeruginosa, activity value is MIC = 6 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Escherichia coli, activity value is MIC = 25 uM||Anti-K.pneumoniae, activity value is MIC = 25 uM||Anti-C.albicans, activity value is MIC = 25 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal Silurana paratropicalis|||Silurana paratropicalis|||skin secrections, Silurana paratropicalis, Cameroon, Africa|||skin secrections, Silurana paratropicalis, Cameroon, Africa N/A skin secrections, Silurana paratropicalis, Cameroon, Africa||There was insufficient material todetermine accurately the hemolytic activity of the peptide againsthuman erythrocytes but the LC50 value was N100 uM.|||There was insufficient material to determine accurately the hemolytic activity of the peptide against human erythrocytes but the LC50 value was >100 uM. "Comp Biochem Physiol Part D Genomics Proteomics. 2011 Jun;6(2):206-12. PubMed|||21498136|||21498136|||Comp Biochem Physiol Part D Genomics Proteomics . 2011 Jun;6(2):206-12. doi: 10.1016/j.cbd.2011.03.003. Epub 2011 Apr 4.|||Comp Biochem Physiol Part D Genomics Proteomics. 2011 Jun;6(2):206-12. PubMed" 27 FPDB03188 AP02519 MFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ Compared to the long form||which was also reproted to be antimicrobial mainly against Gram- bacteria||this short form TSLP (sfTSLP) exhibited a markedly stronger antibacterial activity against B. cereus||E. coli||E. faecalis||S. mitis||S. epidermidis||and C. albicans. (Incubate 2 h followed by plating count).||Anti-Gram+ & Gram-||Antifungal||candidacidal keratinocytes, oral mucosa/salivary glands, skin, gut, Homo sapiens|||keratinocytes, oral mucosa/salivary glands, skin, gut, Homo sapiens N/A keratinocytes, oral mucosa/salivary glands, skin, gut, Homo sapiens "Mucosal Immunol. 2015 Jan;8(1):49-56. PubMed||Sonesson A et al., 2011|||Mucosal Immunol . 2015 Jan;8(1):49-56. doi: 10.1038/mi.2014.41. Epub 2014 May 21.||Sonesson A et al., 2011|||Mucosal Immunol. 2015 Jan;8(1):49-56. PubMed" 63 FPDB03189 AP02520|||Enterocin O16|||AP02520|||DRAMP18259 LGSCVANKIKDEFFAMISISAIVKAAQKKAWKELAVTVLRFAKANGLKTNAIIVAGQLALWAVQCGLS Anti-A narrow-spectrum peptide with MIC in the range of nM. Active against L. sakei LMG 2313 or LMG 3354 or LMG 3355 or LMG 3356 or LMG 3357, activity value is MIC = 0.0005||Anti-and L. plantarum LMG 2003, activity value is MIC = 0.031 ug/ml||Anti-Latilactobacillus sakei LMG 2313, activity value is MIC = 0.0005 ug/ml||Anti-Latilactobacillus sakei LMG 3354, activity value is MIC = 0.25 ug/ml||Anti-Latilactobacillus sakei LMG 3355, activity value is MIC = 0.125 ug/ml||Anti-Latilactobacillus sakei LMG 3356, activity value is MIC = 0.0625 ug/ml||Anti-Latilactobacillus sakei LMG 3357, activity value is MIC = 0.5 ug/ml||Anti-Lactiplantibacillus plantarum LMG 2003, activity value is MIC = 0.031 ug/ml||Anti-Gram+||Antifungal||candidacidal||Antibiofilm||Antimicrobial||Antibacterial Enterococcus faecalis Helix Enterococcus faecalis "J Bacteriol. 2015 Jul 1;197(13):2112-21. PubMed|||https://pubmed.ncbi.nlm.nih.gov/25733609|||J Bacteriol. 2015 Jul 1;197(13):2112-21. PubMed|||J Bacteriol . 2015 Jul;197(13):2112-2121. doi: 10.1128/JB.02513-14. Epub 2015 Mar 2.|||J Bacteriol. 2015 Jul;197(13):2112-21.|||J Bacteriol. 2015 Jul 1;197(13):2112-21. PubMed" 68 FPDB03205 AP02542|||CAMPSQ8186|||Mastoparan-S|||AP02542|||AP02542 LRLKSIVSYAKKVL Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Escherichia coli, activity value is MIC = 28.3 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 26.7 ug/ml||Anti-Pseudomonas aeroginosa, activity value is MIC = 24.2 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 17.6 ug/ml||Anti-Leuconostoc mesenteroides, activity value is MIC = 19.8 ug/ml||Anti-Bacillus cereus, activity value is MIC = 15.1 ug/ml||Anti-Aspergillus niger, activity value is MIC = 24.6 ug/ml||Anti-Aspergillus fumigates, activity value is MIC = 19.3 ug/ml||Anti-andida albicans, activity value is MIC = 20.4 ug/ml||Antibacterial Sphodromantis viridis [Giant African praying mantis)]|||Sphodromantis viridis [Giant African praying mantis)]|||praying mantis, Sphodromantis viridis|||praying mantis, Sphodromantis viridis N/A praying mantis, Sphodromantis viridis|||Human RBC ( 0.2% hemolysis at 10 ug/ml ), ( 0.25% hemolysis at 20 ug/ml ), ( 0.46% hemolysis at 40 ug/ml ), ( 1.2% hemolysis at 60 ug/ml ), ( 2.3% hemolysis at 80 ug/ml ), ( 2.9% hemolysis at 100 ug/ml )|||Human RBC ( 0.2% hemolysis at 10 ug/ml ), ( 0.25% hemolysis at 20 ug/ml ), ( 0.46% hemolysis at 40 ug/ml ), ( 1.2% hemolysis at 60 ug/ml ), ( 2.3% hemolysis at 80 ug/ml ), ( 2.9% hemolysis at 100 ug/ml )|||Mastoparan S (S1 component), µg/ml 10 20 40 60 80 100, hemolysis percentage 0.2 0.25 0.46 1.2 2.3 2.9|||S1 fractions have low hemolytic activity. This peptide lysed only 3% of human red blood cells at the concentration up to 100 ug/ml. "Biochemistry (Mosc). 2015 Apr;80(4):433-40. PubMed|||25869360|||25869360|||Biochemistry (Mosc) . 2015 Apr;80(4):433-40. doi: 10.1134/S0006297915040069.|||Biochemistry (Mosc). 2015 Apr;80(4):433-40. PubMed" 14 FPDB03250 AP02605 SPAIWGCDSFLGYCRLACFAHEASVGQKECAEGMLCCIPNV Anti-Gram+ & Gram-||Antifungal||candidacidal skin secretions, tree frog, Theloderma kwangsiensis, China, Asia|||skin secretions, tree frog, Theloderma kwangsiensis, China, Asia Bridge skin secretions, tree frog, Theloderma kwangsiensis, China, Asia|||The hemolytic ability of defensin-TK was evaluated with human erythrocytes. It has low hemolytic activity on human erythrocytes. When the concentration was 200, 100 and 50 ug/ml, the hemolysis rate of human red blood cells was 6.2, 2.7 and 1.5, respectively.|||Humanredbloodcells were usedtoevaluate thehemolytic capabil ity of defensin-TK. It exerted a low hemolytic activity on human red cells. At concentrations of 200, 100 and 50 ug/ml, the hemolysis ratio of humanred cells was 6.2%, 2.7% and 1.5%, respectively "Gene. 2016 Jan 15;576(1 Pt 1):136-40. PubMed|||Gene . 2016 Jan 15;576(1 Pt 1):136-40. doi: 10.1016/j.gene.2015.09.086. Epub 2015 Oct 8.|||Gene. 2016 Jan 15;576(1 Pt 1):136-40. PubMed" 41 FPDB03251 AP02606 FFCFKGTPCG Anti-Gram+ & Gram-||Antifungal||candidacidal Rana limnocharis, China, Asia N/A Rana limnocharis, China, Asia "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 10 FPDB03252 AP02607|||Nigrocin-AA1|||Nigrocin-AA1|||AP02607|||AP02607 GLLSGILGAGKRIVCGLSGLC Anti-S. aureus ATCC25923 or IS10# or IS37#, activity value is MIC = 5||Anti-E. faecalis ATCC29212, activity value is MIC = 10 ug/ml||Anti-E. coli ATCC25922 or IS37# or IS117# or IS218#, activity value is MIC = 5||Anti-E. cloacae ATCC13047, activity value is MIC = 5||Anti-K. pneumoniae ATCC700603 or IS 59#, activity value is MIC = 1||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa ATCC27853 or IS350#, activity value is MIC = 10||Anti-C. albicans ATCC2002 or ATCC90028, activity value is MIC = 2||Anti-C. parapsilosis ATCC22019, activity value is MIC = 5 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus IS10#, activity value is MIC = 5 ug/ml||Anti-Staphylococcus aureus IS37#, activity value is MIC = 10 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 10 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5 ug/ml||Anti-Escherichia coli IS37#, activity value is MIC = 10 ug/ml||Anti-Escherichia coli IS117#, activity value is MIC = 10 ug/ml||Anti-Escherichia coli IS218#, activity value is MIC = 20 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 5 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 1 ug/ml||Anti-Klebsiella pneumoniae IS59#, activity value is MIC = 20 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa CMCCB 1010, activity value is MIC = 1 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa IS350#, activity value is MIC = 20 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 2 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 2.5 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 5 ug/ml||Anti-Gram+ & Gram-||candidacidal Amolops afghanus|||Amolops afghanus, China, Asia N/A Amolops afghanus, China, Asia|||Staphylococcus aureus ATCC 25923[MIC = 10 ug/ml], Staphylococcus aureus IS10#[MIC = 5 ug/ml], Staphylococcus aureus IS37#[MIC = 10 ug/ml], Enterococcus faecalis ATCC 29212[MIC = 10 ug/ml], Escherichia coli ATCC 25922[MIC = 5 ug/ml], Escherichia coli IS37#[MIC = 10 ug/ml], Escherichia coli IS117#[MIC = 10 ug/ml], Escherichia coli IS218#[MIC = 20 ug/ml], Enterobacter cloacae ATCC 13047[MIC = 5 ug/ml], Klebsiella pneumoniae ATCC 700603[MIC = 1 ug/ml], Klebsiella pneumoniae IS59#[MIC = 20 ug/ml], Shigella dysenteriae[MIC = 10 ug/ml], Pseudomonas aeruginosa CMCCB 1010[MIC = 1 ug/ml], Pseudomonas aeruginosa ATCC 27853[MIC = 10 ug/ml], Pseudomonas aeruginosa IS350#[MIC = 20 ug/ml], Candida albicans ATCC 2002[MIC = 2 ug/ml], Candida albicans ATCC 90028[MIC = 2.5 ug/ml], Candida parapsilosis ATCC 22019[MIC = 5 ug/ml] "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||26452973|||26452973|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 21 FPDB03253 AP02608|||Nigrocin-HL|||Nigrocin-HL|||AP02608|||AP02608 GLLSGILGAGKKIVCGLSGLC Anti-S. aureus ATCC25923, activity value is MIC = 10 ug/ml||Anti-S. aureus IS10#, activity value is MIC = 5 ug/ml||Anti-S. aureus IS37#, activity value is MIC = 10 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 10 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 5 ug/ml||Anti-E. coli IS37#, activity value is MIC = 10 ug/ml||Anti-E. coli IS117#, activity value is MIC = 10 ug/ml||Anti-E. coli IS218#, activity value is MIC = 20 ug/ml||Anti-E. cloacae ATCC13047, activity value is MIC = 5||Anti-K. pneumoniae ATCC700603, activity value is MIC = 1 ug/ml||Anti-K. pneumoniae IS 59#, activity value is MIC = 20 ug/ml||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa IS350#, activity value is MIC = 20 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-C. albicans ATCC90028, activity value is MIC = 2.5 ug/ml||Anti-C. parapsilosis ATCC22019, activity value is MIC = 5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 62.7 ug||Anti-Escherichia coli, activity value is MIC = 125.4 ug||Anti-Candida albicans, activity value is MIC = 62.7 ug||Anti-DTMR24, activity value is MIC = 501.61 ug||Anti-Gram+ & Gram-||Antifungal||candidacidal Hylarana latouchii [Kuatun frog]|||Rana exilispinosa, and skin secretion Hylarana latouchii; Sylyirana latouchii, China, Asia|||Rana exilispinosa, and skin secretion Hylarana latouchii; Sylyirana latouchii, China, Asia N/A Rana exilispinosa, and skin secretion Hylarana latouchii; Sylyirana latouchii, China, Asia|||Horse erythrocytes (100% hemolysis at 512 uM)|||Horse erythrocytes (100% hemolysis at 512 uM) "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed||Bao et al., 2018|||30555431|||30555431|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.||Bao et al., 2018|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 21 FPDB03254 AP02609|||Brevinin-1RL1|||Brevinin-1RL1|||AP02609|||DRAMP32339|||AP02609 FFPLIAGLAARFLPKIFCSITKRC Anti-S. aureus ATCC25923 or IS10# or IS37#, activity value is MIC = 5||Anti-E. faecalis ATCC29212, activity value is MIC = 5 ug/ml||Anti-E. coli ATCC25922 or IS37# or IS117#, activity value is MIC = 1||Anti-E. cloacae ATCC13047, activity value is MIC = 2.5||Anti-K. pneumoniae ATCC700603, activity value is MIC = 2.5 ug/ml||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 5 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 ug/ml||Anti-C. albicans ATCC2002 or ATCC90028, activity value is MIC = 5||Anti-C. parapsilosis ATCC22019, activity value is MIC = 20 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5 ug/ml||Anti-Staphylococcus aureus IS10#, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus IS37#, activity value is MIC = 5 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 ug/ml||Anti-Escherichia coli IS37#, activity value is MIC = 2.5 ug/ml||Anti-Escherichia coli IS117#, activity value is MIC = 10 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 2.5 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 2.5 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa CMCCB 1010, activity value is MIC = 5 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 10 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 5 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 10 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 20 ug/ml||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||candidacidal Rana limnocharis|||Rana limnocharis|||Rana limnocharis, China, Asia|||Frog Skin Secretion|||Rana limnocharis, China, Asia N/A Rana limnocharis, China, Asia|||Staphylococcus aureus ATCC 25923[MIC = 5 ug/ml], Staphylococcus aureus IS10#[MIC = 10 ug/ml], Staphylococcus aureus IS37#[MIC = 5 ug/ml], Enterococcus faecalis ATCC 29212[MIC = 5 ug/ml], Escherichia coli ATCC 25922[MIC = 1 ug/ml], Escherichia coli IS37#[MIC = 2.5 ug/ml], Escherichia coli IS117#[MIC = 10 ug/ml], Escherichia coli IS218#, Enterobacter cloacae ATCC 13047[MIC = 2.5 ug/ml], Klebsiella pneumoniae ATCC 700603[MIC = 2.5 ug/ml], Klebsiella pneumoniae IS59#, Shigella dysenteriae[MIC = 10 ug/ml], Pseudomonas aeruginosa CMCCB 1010[MIC = 5 ug/ml], Pseudomonas aeruginosa ATCC 27853[MIC = 10 ug/ml], Pseudomonas aeruginosa IS350#, Candida albicans ATCC 2002[MIC = 5 ug/ml], Candida albicans ATCC 90028[MIC = 10 ug/ml], Candida parapsilosis ATCC 22019[MIC = 20 ug/ml] "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||26452973|||26452973|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Molecules. 2021 Apr 3;26(7):2059|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 24 FPDB03255 AP02610 FLPGLECVSGLKIVPTVFCAITRIC Anti-S. aureus ATCC25923, activity value is MIC = 10 ug/ml||Anti-S. aureus IS10#, activity value is MIC = 5 ug/ml||Anti-S. aureus IS37#, activity value is MIC = 10 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 10 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 5 ug/ml||Anti-E. coli IS37#, activity value is MIC = 10 ug/ml||Anti-E. coli IS117#, activity value is MIC = 10 ug/ml||Anti-E. coli IS218#, activity value is MIC = 20 ug/ml||Anti-E. cloacae ATCC13047, activity value is MIC = 5||Anti-K. pneumoniae ATCC700603, activity value is MIC = 1 ug/ml||Anti-K. pneumoniae IS 59#, activity value is MIC = 20 ug/ml||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa IS350#, activity value is MIC = 20 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-C. albicans ATCC90028, activity value is MIC = 2.5 ug/ml||Anti-C. parapsilosis ATCC22019, activity value is MIC = 5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Rana exilispinosa, China, Asia N/A Rana exilispinosa, China, Asia "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 25 FPDB03256 AP02611|||Brevinin-1RE2|||Brevinin-1RE2|||AP02611|||AP02611 VIPFVASVAAEMMQHVYCAASKRC Anti-S. aureus ATCC25923, activity value is MIC = 10 ug/ml||Anti-S. aureus IS10#, activity value is MIC = 5 ug/ml||Anti-S. aureus IS37#, activity value is MIC = 10 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 10 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 5 ug/ml||Anti-E. coli IS37#, activity value is MIC = 10 ug/ml||Anti-E. coli IS117#, activity value is MIC = 10 ug/ml||Anti-E. coli IS218#, activity value is MIC = 20 ug/ml||Anti-E. cloacae ATCC13047, activity value is MIC = 5||Anti-K. pneumoniae ATCC700603, activity value is MIC = 1 ug/ml||Anti-K. pneumoniae IS 59#, activity value is MIC = 20 ug/ml||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa IS350#, activity value is MIC = 20 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-C. albicans ATCC90028, activity value is MIC = 2.5 ug/ml||Anti-C. parapsilosis ATCC22019, activity value is MIC = 5 ug/ml||Anti-P. aeruginosa IS350#, activity value is MIC = 50 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus IS10#, activity value is MIC = 50 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 5 ug/ml||Anti-Escherichia coli IS37#, activity value is MIC = 50 ug/ml||Anti-Escherichia coli IS117#, activity value is MIC = 20 ug/ml||Anti-Escherichia coli IS218#, activity value is MIC = 50 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 10 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 10 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa CMCCB 1010, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 20 ug/ml||Anti-Pseudomonas aeruginosa IS350#, activity value is MIC = 50 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 5 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 10 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 20 ug/ml||Anti-Gram+ & Gram-||candidacidal Rana exilispinosa|||Rana exilispinosa|||Rana exilispinosa, China, Asia|||Rana exilispinosa, China, Asia N/A Rana exilispinosa, China, Asia|||Staphylococcus aureus ATCC 25923[MIC = 10 ug/ml], Staphylococcus aureus IS10#[MIC = 50 ug/ml], Staphylococcus aureus IS37#, Enterococcus faecalis ATCC 29212[MIC = 5 ug/ml], Escherichia coli ATCC 25922[MIC = 5 ug/ml], Escherichia coli IS37#[MIC = 50 ug/ml], Escherichia coli IS117#[MIC = 20 ug/ml], Escherichia coli IS218#[MIC = 50 ug/ml], Enterobacter cloacae ATCC 13047[MIC = 10 ug/ml], Klebsiella pneumoniae ATCC 700603[MIC = 10 ug/ml], Klebsiella pneumoniae IS59#, Shigella dysenteriae[MIC = 10 ug/ml], Pseudomonas aeruginosa CMCCB 1010[MIC = 10 ug/ml], Pseudomonas aeruginosa ATCC 27853[MIC = 20 ug/ml], Pseudomonas aeruginosa IS350#[MIC = 50 ug/ml], Candida albicans ATCC 2002[MIC = 5 ug/ml], Candida albicans ATCC 90028[MIC = 10 ug/ml], Candida parapsilosis ATCC 22019[MIC = 20 ug/ml] "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||26452973|||26452973|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 24 FPDB03257 AP02612|||Brevinin-2RE1|||Brevinin-2RE1|||AP02612|||AP02612 SFLSTFKKLAIDAAKNAGQSVLHTLTCKLDNQC Anti-S. aureus ATCC25923, activity value is MIC = 10 ug/ml||Anti-S. aureus IS10#, activity value is MIC = 5 ug/ml||Anti-S. aureus IS37#, activity value is MIC = 10 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 10 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 5 ug/ml||Anti-E. coli IS37#, activity value is MIC = 10 ug/ml||Anti-E. coli IS117#, activity value is MIC = 10 ug/ml||Anti-E. coli IS218#, activity value is MIC = 20 ug/ml||Anti-E. cloacae ATCC13047, activity value is MIC = 5||Anti-K. pneumoniae ATCC700603, activity value is MIC = 1 ug/ml||Anti-K. pneumoniae IS 59#, activity value is MIC = 20 ug/ml||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa IS350#, activity value is MIC = 20 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-C. albicans ATCC90028, activity value is MIC = 2.5 ug/ml||Anti-C. parapsilosis ATCC22019, activity value is MIC = 5 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus IS10#, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus IS37#, activity value is MIC = 50 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 20 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 20 ug/ml||Anti-Escherichia coli IS117#, activity value is MIC = 50 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 5 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 10 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 20 ug/ml||Anti-Pseudomonas aeruginosa CMCCB 1010, activity value is MIC = 5 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 10 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 20 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 20 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 50 ug/ml||Anti-Gram+ & Gram-||candidacidal Rana exilispinosa|||Rana exilispinosa|||Rana exilispinosa, China, Asia|||Rana exilispinosa, China, Asia N/A Rana exilispinosa, China, Asia "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||26452973|||26452973|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 33 FPDB03258 AP02613|||Brevinin-1AA1|||Brevinin-1AA1|||AP02613|||AP02613 FFPSIAGLAAKFLPKIFCSITKRC Anti-S. aureus ATCC25923, activity value is MIC = 10 ug/ml||Anti-S. aureus IS10#, activity value is MIC = 5 ug/ml||Anti-S. aureus IS37#, activity value is MIC = 10 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 10 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 5 ug/ml||Anti-E. coli IS37#, activity value is MIC = 10 ug/ml||Anti-E. coli IS117#, activity value is MIC = 10 ug/ml||Anti-E. coli IS218#, activity value is MIC = 20 ug/ml||Anti-E. cloacae ATCC13047, activity value is MIC = 5||Anti-K. pneumoniae ATCC700603, activity value is MIC = 1 ug/ml||Anti-K. pneumoniae IS 59#, activity value is MIC = 20 ug/ml||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa IS350#, activity value is MIC = 20 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-C. albicans ATCC90028, activity value is MIC = 2.5 ug/ml||Anti-C. parapsilosis ATCC22019, activity value is MIC = 5 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 5 ug/ml||Anti-Staphylococcus aureus IS10#, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus IS37#, activity value is MIC = 5 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 ug/ml||Anti-Escherichia coli IS37#, activity value is MIC = 50 ug/ml||Anti-Escherichia coli IS117#, activity value is MIC = 50 ug/ml||Anti-Escherichia coli IS218#, activity value is MIC = 50 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 20 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 10 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 5 ug/ml||Anti-Pseudomonas aeruginosa CMCCB 1010, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 2.5 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 0.5 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 5 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 2.5 ug/ml||Anti-Gram+ & Gram-||candidacidal Amolops afghanus|||Amolops afghanus|||Amolops afghanus, China, Asia|||Amolops afghanus, China, Asia N/A Amolops afghanus, China, Asia|||Staphylococcus aureus ATCC 25923[MIC = 5 ug/ml], Staphylococcus aureus IS10#[MIC = 10 ug/ml], Staphylococcus aureus IS37#[MIC = 5 ug/ml], Enterococcus faecalis ATCC 29212[MIC = 5 ug/ml], Escherichia coli ATCC 25922[MIC = 1 ug/ml], Escherichia coli IS37#[MIC = 50 ug/ml], Escherichia coli IS117#[MIC = 50 ug/ml], Escherichia coli IS218#[MIC = 50 ug/ml], Enterobacter cloacae ATCC 13047[MIC = 20 ug/ml], Klebsiella pneumoniae ATCC 700603[MIC = 10 ug/ml], Klebsiella pneumoniae IS59#, Shigella dysenteriae[MIC = 5 ug/ml], Pseudomonas aeruginosa CMCCB 1010[MIC = 10 ug/ml], Pseudomonas aeruginosa ATCC 27853[MIC = 2.5 ug/ml], Pseudomonas aeruginosa IS350#, Candida albicans ATCC 2002[MIC = 0.5 ug/ml], Candida albicans ATCC 90028[MIC = 5 ug/ml], Candida parapsilosis ATCC 22019[MIC = 2.5 ug/ml] "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||26452973|||26452973|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 24 FPDB03259 AP02614|||Brevinin-1AA2|||Brevinin-1AA2|||AP02614|||AP02614 FLPAVLRVAAKVGPAVFCAITQKC Anti-S. aureus ATCC25923, activity value is MIC = 10 ug/ml||Anti-S. aureus IS10#, activity value is MIC = 5 ug/ml||Anti-S. aureus IS37#, activity value is MIC = 10 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 10 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 5 ug/ml||Anti-E. coli IS37#, activity value is MIC = 10 ug/ml||Anti-E. coli IS117#, activity value is MIC = 10 ug/ml||Anti-E. coli IS218#, activity value is MIC = 20 ug/ml||Anti-E. cloacae ATCC13047, activity value is MIC = 5||Anti-K. pneumoniae ATCC700603, activity value is MIC = 1 ug/ml||Anti-K. pneumoniae IS 59#, activity value is MIC = 20 ug/ml||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa IS350#, activity value is MIC = 20 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-C. albicans ATCC90028, activity value is MIC = 2.5 ug/ml||Anti-C. parapsilosis ATCC22019, activity value is MIC = 5 ug/ml||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2.5 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 10 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.5 ug/ml||Anti-Escherichia coli IS37#, activity value is MIC = 50 ug/ml||Anti-Escherichia coli IS117#, activity value is MIC = 50 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 5 ug/ml||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 10 ug/ml||Anti-Klebsiella pneumoniae IS59#, activity value is MIC = 5 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa CMCCB 1010, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 5 ug/ml||Anti-Pseudomonas aeruginosa IS350#, activity value is MIC = 10 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 0.5 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 10 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 5 ug/ml||Anti-Gram+ & Gram-||candidacidal Amolops afghanus|||Amolops afghanus|||Amolops afghanus, China, Asia|||Amolops afghanus, China, Asia N/A Amolops afghanus, China, Asia|||Staphylococcus aureus ATCC 25923[MIC = 2.5 ug/ml], Staphylococcus aureus IS10#, Staphylococcus aureus IS37#, Enterococcus faecalis ATCC 29212[MIC = 10 ug/ml], Escherichia coli ATCC 25922[MIC = 2.5 ug/ml], Escherichia coli IS37#[MIC = 50 ug/ml], Escherichia coli IS117#[MIC = 50 ug/ml], Escherichia coli IS218#, Enterobacter cloacae ATCC 13047[MIC = 5 ug/ml], Klebsiella pneumoniae ATCC 700603[MIC = 10 ug/ml], Klebsiella pneumoniae IS59#[MIC = 5 ug/ml], Shigella dysenteriae[MIC = 10 ug/ml], Pseudomonas aeruginosa CMCCB 1010[MIC = 10 ug/ml], Pseudomonas aeruginosa ATCC 27853[MIC = 5 ug/ml], Pseudomonas aeruginosa IS350#[MIC = 10 ug/ml], Candida albicans ATCC 2002[MIC = 0.5 ug/ml], Candida albicans ATCC 90028[MIC = 10 ug/ml], Candida parapsilosis ATCC 22019[MIC = 5 ug/ml] "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||26452973|||26452973|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 24 FPDB03260 AP02615 GIFSKFAGKGLKNLFMKGAKTIGKEVGMDVLRTGIDIAGCKIKGEC Anti-S. aureus ATCC25923, activity value is MIC = 10 ug/ml||Anti-S. aureus IS10#, activity value is MIC = 5 ug/ml||Anti-S. aureus IS37#, activity value is MIC = 10 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 10 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 5 ug/ml||Anti-E. coli IS37#, activity value is MIC = 10 ug/ml||Anti-E. coli IS117#, activity value is MIC = 10 ug/ml||Anti-E. coli IS218#, activity value is MIC = 20 ug/ml||Anti-E. cloacae ATCC13047, activity value is MIC = 5||Anti-K. pneumoniae ATCC700603, activity value is MIC = 1 ug/ml||Anti-K. pneumoniae IS 59#, activity value is MIC = 20 ug/ml||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa IS350#, activity value is MIC = 20 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-C. albicans ATCC90028, activity value is MIC = 2.5 ug/ml||Anti-C. parapsilosis ATCC22019, activity value is MIC = 5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Rana limnocharis, China, Asia N/A Rana limnocharis, China, Asia "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 46 FPDB03261 AP02616 GIFSKFVGKGLKNLFMKGAKTIGREVGMDVLRTGIDIAGCKIKGEC Anti-S. aureus ATCC25923, activity value is MIC = 10 ug/ml||Anti-S. aureus IS10#, activity value is MIC = 5 ug/ml||Anti-S. aureus IS37#, activity value is MIC = 10 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 10 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 5 ug/ml||Anti-E. coli IS37#, activity value is MIC = 10 ug/ml||Anti-E. coli IS117#, activity value is MIC = 10 ug/ml||Anti-E. coli IS218#, activity value is MIC = 20 ug/ml||Anti-E. cloacae ATCC13047, activity value is MIC = 5||Anti-K. pneumoniae ATCC700603, activity value is MIC = 1 ug/ml||Anti-K. pneumoniae IS 59#, activity value is MIC = 20 ug/ml||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa IS350#, activity value is MIC = 20 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-C. albicans ATCC90028, activity value is MIC = 2.5 ug/ml||Anti-C. parapsilosis ATCC22019, activity value is MIC = 5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Rana exilispinosa, China, Asia N/A Rana exilispinosa, China, Asia "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 46 FPDB03262 AP02617 GIFSKFAGRGLKNLFMKGAKKIGKEVGMDVLRTGIDIAGCKIRGEC Anti-S. aureus ATCC25923, activity value is MIC = 10 ug/ml||Anti-S. aureus IS10#, activity value is MIC = 5 ug/ml||Anti-S. aureus IS37#, activity value is MIC = 10 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 10 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 5 ug/ml||Anti-E. coli IS37#, activity value is MIC = 10 ug/ml||Anti-E. coli IS117#, activity value is MIC = 10 ug/ml||Anti-E. coli IS218#, activity value is MIC = 20 ug/ml||Anti-E. cloacae ATCC13047, activity value is MIC = 5||Anti-K. pneumoniae ATCC700603, activity value is MIC = 1 ug/ml||Anti-K. pneumoniae IS 59#, activity value is MIC = 20 ug/ml||Anti-B. dysenteriae, activity value is MIC = 10 ug/ml||Anti-B. pyocyaneus CMCCB1010, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa IS350#, activity value is MIC = 20 ug/ml||Anti-C. albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-C. albicans ATCC90028, activity value is MIC = 2.5 ug/ml||Anti-C. parapsilosis ATCC22019, activity value is MIC = 5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Amolops afghanus, China, Asia N/A Amolops afghanus, China, Asia "Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed|||Chem Biol Drug Des . 2016 Mar;87(3):419-24. doi: 10.1111/cbdd.12672. Epub 2015 Nov 13.|||Chem Biol Drug Des. 2016 Mar;87(3):419-24. PubMed" 46 FPDB03270 AP02626|||Cathelicidin 2 Cl, Cl-CATH2|||Cathelicidin 2 Cl, Cl-CATH2|||AP02626|||AP02626 LIQRGRFGRFLGRIRRFRPRINFDIRARGSIRLG Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory||Antibacterial||Anti-Escherichia coli ATCC 25922, activity value is MIC = 18.75 ug/ml||Anti-Escherichia coli 08040726, activity value is MIC = 37.5 ug/ml||Anti-Klebsiella pneumoniae 1400, activity value is MIC = 18.75 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 18.75 ug/ml||Anti-Stenotrophomonas maltophilia 7407, activity value is MIC = 75 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 9.38 ug/ml||Anti-Staphylococcus aureus 08032706, activity value is MIC = 18.75 ug/ml||Anti-Staphylococcus aureus 08032810, activity value is MIC = 9.38 ug/ml||Anti-Bacillus cereus 1373, activity value is MIC = 9.38 ug/ml||Anti-Bacillus subtilis 1345, activity value is MIC = 75 ug/ml||Anti-Enterococcus faecalis 1396, activity value is MIC = 75 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans 08022821, activity value is MIC = 75 ug/ml||Anti-Candida albicans 08030102, activity value is MIC = 150 ug/ml||Anti-Candida glabrata 08A802, activity value is MIC = 18.75 ug/ml||Anti-Candida glabrata 091223, activity value is MIC = 150 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 18.75||Anti-S. maltophilia 7407, activity value is MIC = 75 ug/ml||Anti-B. cereus 1373, activity value is MIC = 9.4||Anti-E. faecalis 1396, activity value is MIC = 75 ug/ml||Anti-C. albicans 08030809, activity value is MIC = 37.5||Anti-and C. glabrata 08A802, activity value is MIC = 18.8 Columba livia|||Columba livia|||rock dove, rock pigeon, or common pigeon, Columba livia|||rock dove, rock pigeon, or common pigeon, Columba livia Rich rock dove, rock pigeon, or common pigeon, Columba livia||The hemolytic activity of the peptide against human erythrocyteswas determined as a measure of toxicity to mammalian cells. Figure 4A showed the hemolytic activitytoward human erythrocytes, with 50% killing of mammalian erythrocytes occurring at 20 μ M and 32 μ Mfor dCATH in the absence (a) or presence (b) of 10% fetal calf serum (FBS), respectively. In contrast,melittin used as a control peptide caused 50% killing of mammalian erythrocytes occurring at 5 μ M.Thehemolytic activity of dCATH was reduced in the presence of 10% FBS.|||Human erythrocytes (13% Hemolysis at 200 ug/ml|||Human erythrocytes (13% Hemolysis at 200 ug/ml "Sci Rep. 2015 Jul 21;5:11082. PubMed|||26194630|||26194630|||Fish Shellfish Immunol . 2016 Jan:48:30-8. doi: 10.1016/j.fsi.2015.11.019. Epub 2015 Nov 14.|||Sci Rep. 2015 Jul 21;5:11082. PubMed" 34 FPDB03272 AP02631|||Piscidin Of|||Piscidin Of|||AP02631|||AP02631 FLGMLLHGVGHAIHGLIHGKQNVE Anti-A 17-residue segment was used to test peptide activity. Active against Gram- E. coli, activity value is MIC = 45 uM||Anti-E-tarda, activity value is MIC > 90 uM||Anti-V. tapetis, activity value is MIC = 22.5 uM||Anti-S. iniae, activity value is MIC = 45 uM||Anti-C. albicans KCCM 11282, activity value is MIC = 22.5 uM||Anti-S. cerevisiae, activity value is MIC = 11.25 uM||Anti-and parasite M. avidus, activity value is MIC = 0.4 uM||Antibacterial||Antiparasitic||Antifungal||Anti-Escherichia coli, activity value is MIC = 45 uM||Anti-Edwardsiella tarda, activity value is MIC > 90 uM||Anti-Edwardsiella tarda, activity value is IC50 = 45 uM||Anti-Streptococcus iniae, activity value is MIC = 45 uM||Anti-Streptococcus iniae, activity value is IC50 = 22.5 uM||Anti-Vibrio tapetis KCTC 12728, activity value is MIC = 22.5 uM||Anti-Vibrio tapetis KCTC 12728, activity value is IC50 = 5.6 uM||Anti-Candida albicans KCCM 11282, activity value is MIC = 22.5 uM||Anti-Candida albicans KCCM 11282, activity value is IC50 = 2.8 uM||Anti-Saccharomyces cerevisiae KCCM 11293, activity value is MIC = 11.25 uM||Anti-Saccharomyces cerevisiae KCCM 11293, activity value is IC50 = 1.4 uM||Anti-Miamiensis avidus, activity value is MIC = 0.4 uM||Anti-Gram+ & Gram-||candidacidal Synthetic construct|||Synthetic construct|||rock bream, Oplegnathus fasciatus|||rock bream, Oplegnathus fasciatus Helix rock bream, Oplegnathus fasciatus|||Human erythrocytes (3% Hemolysis at 56.02-28.01 uM|||Human erythrocytes (3% Hemolysis at 56.02-28.01 uM|||The pOf-Pis1 demonstrated very weak hemolytic activity (Fig. 10). Even at the highest concentration (56.02 uM), pOf-Pis1 lysed less than 3.25% of erythrocytes, compared to the positive control in 0.5 h.The lowest concentration (0.11 uM) lysed~1.7 of erythrocytes. "Fish Shellfish Immunol. 2016 Jan;48:154-68. PubMed|||26549174|||26549174|||Fish Shellfish Immunol . 2016 Jan:48:154-68. doi: 10.1016/j.fsi.2015.11.005. Epub 2015 Nov 6.|||Fish Shellfish Immunol. 2016 Jan;48:154-68. PubMed" 24 FPDB03287 AP02648 VPTRHARPRPQPRPRPGTCPDTSDIVSICVVTERNCFSDGECGAGQKCCPIGCGRECLAVGSPYGK Anti-Gram+ & Gram-||Antifungal||candidacidal||Enzyme inhibitor haemocytes, fleshy prawns, Fenneropenaeus chinensis|||haemocytes, fleshy prawns, Fenneropenaeus chinensis N/A haemocytes, fleshy prawns, Fenneropenaeus chinensis Aquaculture 2008;284:246–259. 66 FPDB03305 AP02675|||HYL|||DRAMP21154|||HYL|||AP02675|||DRAMP21154|||AP02675 GIMSSLMKKLAAHIAK Anti-HYL exhibited weak antimicrobial activity against several strains of pathogenic bacteria S. aureus, activity value is MIC = 53||Anti-S. epidermidis, activity value is MIC = 13 uM||Anti-E. coli, activity value is MIC = 15 uM||Anti-P. aeruginosa 5482, activity value is MIC = 20||Anti-Staphylococcus aureus 6271, activity value is MIC = 63 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 13 uM||Anti-Escherichia coli, activity value is MIC = 15 uM||Anti-Pseudomonas aeruginosa 5482, activity value is MIC = 20 uM||Anti-Candida albicans, activity value is MIC = 18 uM||Antibacterial||Antifungal||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 15 uM||Anti-##Fungi : Candida albicans, activity value is MIC = 18 uM||Anti-Gram+ & Gram-||candidacidal Hylaeus signatus|||Solitary wild bee Hylaeus signatus|||Hylaeus signatus [Wild bee]|||venom, the Wild Bee, Hylaeus signatus , Europe|||Solitary wild bee Hylaeus signatus|||venom, the Wild Bee, Hylaeus signatus , Europe Helix||Alpha helix "venom, the Wild Bee, Hylaeus signatus||The synthesised EeCentrocin 1 (HC, HC-diBr and LC) peptide analogues displayed no or minor haemolytic activity at a concentration of100 uM(Fig 9, raw data in S10 Table), a concentration which is 16 times higher than the MIC against theleast sensitive bacteria (Staphylococci) tested in this study. No or minor haemolytic activity is a prerequisite if the peptides are ever to be exploited clinically or as food additives [70]. EeCentrocin 2 HC was more haemolytic, displaying 11.7,18.9 and 56.3% haemolysis at concentrations 25.0, 50.0 and 100 uM, respectively. The reason for this higher haemolytic activity ofEeCentrocin 2 compared to EeCentrocin 1 is unclear. However, increasing physicochemical parameterslike hydrophobicity and hydrophobic face are known to enhance the haemolytic activity ofα-helical AMPs [71].|||Human RBCs ( LC50 = >400 uM)|||- Test subject: human red blood cells, incubation conditions at 37°C for 1 hour, detection wavelength 540 nm; negative control (physiological saline) shows 0% hemolysis, positive control (0.2% Triton X-100) shows 100% hemolysis. - Core indicator: the 50% hemolysis concentration (LC_{50}) is the key parameter; the higher the value, the weaker the hemolytic activity, detailed as follows: - Natural peptide HYL: LC_{50} > 400 μM, extremely low hemolytic activity. - Low-hemolysis analogs (LC_{50} > 400 μM): HYL-1, HYL-2, HYL-3, HYL-4, HYL-8, HYL-9, HYL-10, HYL-11, HYL-15, HYL-16, HYL-22, HYL-23 (12 in total), all maintain extremely low hemolytic activity, and some have significantly enhanced antibacterial activity (e.g., HYL-8 against Pseudomonas aeruginosa has MIC = 5 μM, a 4-fold increase compared to the natural peptide). - Moderate-hemolysis analogs (LC_{50} = 100–300 μM): HYL-5 (320 μM), HYL-12 (284 μM), HYL-13 (333 μM), HYL-14 (373 μM), HYL-17 (364 μM), HYL-18 (165 μM), HYL-20 (197 μM), HYL-21 (191 μM). - High-hemolysis analogs (LC_{50} < 100 μM): HYL-6 (93 μM), HYL-7 (88 μM), HYL-24 (115 μM), HYL-25 (57 μM), with HYL-25 showing the strongest hemolytic activity. - Analogs without antibacterial activity: HYL-26 (LC_{50} > 400 μM), although hemolysis is low, antibacterial activity is completely lost (MIC > 100 μM). - Key correlation: hemolysis is positively correlated with hydrophobicity (e.g., HYL-25 introduces 2 tryptophans, increasing hydrophobicity and reducing LC_{50} to 57 μM), while increasing cationicity (e.g., HYL-8 has a net charge of 6) can enhance antibacterial activity without increasing hemolytic activity.|||Human RBCs ( LC50 = >400 uM)|||[Ref.26998557] LC50>400 uM against human red blood cells" "J Nat Prod. 2016 Apr 22;79(4):1073-83. PubMed|||26998557|||J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.||Ref.26998557|||26998557|||J Nat Prod . 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129. Epub 2016 Mar 21.|||J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.||Ref.26998557|||J Nat Prod. 2016 Apr 22;79(4):1073-83. PubMed" 16 FPDB03309 AP02680|||SJGAP|||AP02680 VKVGINGFGRIGRLVTRAAFHGKKVEIVAIND Anti-B. subtilis, activity value is MIC = 3.9||Anti-M. luteus, activity value is MIC = 26 ug/ml||Anti-S. aureus, activity value is MIC = 9.7 ug/ml||Anti-S. iniae, activity value is MIC = 4.8 ug/ml||Anti-A. hydrophila, activity value is MIC = 25 ug/ml||Anti-E. coli D31 or ML35p or KCTC1116, activity value is MIC = 2.7||Anti-P. aeruginosa KCTC2004, activity value is MIC = 5.6 ug/ml||Anti-S. enterica KCTC2514, activity value is MIC = 2 ug/ml||Anti-S. flexneri KCTC2517, activity value is MIC = 1.8 ug/ml||Anti-S. sonnei KCTC2009, activity value is MIC = 1.8 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Katsuwonus pelamis|||skin, skipjack tuna, Katsuwonus pelamis|||skin, skipjack tuna, Katsuwonus pelamis N/A skin, skipjack tuna, Katsuwonus pelamis|||Human erythrocytes (0% Hemolysis at <100 ug/ml|||However, piscidin 1 caused considerable hemolysis even at the 12.5 ug/ml concentration. "Fish Shellfish Immunol. 2014 Feb;36(2):571-81.PubMed|||24412436|||Fish Shellfish Immunol . 2014 Feb;36(2):571-81. doi: 10.1016/j.fsi.2014.01.003. Epub 2014 Jan 9." 32 FPDB03316 AP02689|||Megin 1|||DRAMP20784|||Megin 1|||AP02689|||DRAMP20784|||AP02689 FLKGCWTKWYSLKPKCPF Anti-E. coli ATCC25922, activity value is MIC = 25 ug/ml||Anti-B. dysenteriae, activity value is MIC = 3 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 6.25 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC = 3 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 50 ug/ml||Anti-C.albicans ATCC2002, activity value is MIC = 50 ug/ml||Anti-Escherichia coli, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 6.25 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 3 ug/ml||Anti-C.albicans, activity value is MIC = 50 ug/ml||Anti-##Gram-positive bacteria:Staphylococcus aureus, activity value is MIC = 6.25 ug/ml||Anti-##Fungi:C.albicans, activity value is MIC = 50 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Megophrys minor [Spadefoot toad]|||Amphibian skin|||skin venoms, spadefoot toad, Megophrys minor, Asia.|||Amphibian skin|||skin venoms, spadefoot toad, Megophrys minor, Asia. N/A "skin venoms, spadefoot toad, Megophrys minor , Asia.|||hRBCs ( 2.3% hemolysis at 25 ug/ml)|||Megin 1 Hemolytic Value 25 ug · mL¹: human erythrocyte hemolysis rate 2.3%, rabbit erythrocyte hemolysis rate 3.1% 50 ug · mL¹: human erythrocyte hemolysis rate 5.6, rabbit erythrocyte hemolysis rate 7.3 100 ug · mL¹: human erythrocyte hemolysis rate 18.7, rabbit erythrocyte hemolysis rate 20.5 200 ug · mL¹: human erythrocyte hemolysis rate 29.5, rabbit erythrocyte hemolysis rate 32.9 Megin 2 Hemolytic Value 25 ug · mL¹: human erythrocyte hemolysis rate 3.9%, rabbit erythrocyte hemolysis rate 5.6% 50 ug · mL¹: human erythrocyte hemolysis rate 13.7, rabbit erythrocyte hemolysis rate 15.2 100 ug · mL¹: human erythrocyte hemolysis rate 27.7, rabbit erythrocyte hemolysis rate 36.2 200 ug · mL¹: human erythrocyte hemolysis rate 45.3, rabbit erythrocyte hemolysis rate 50.3|||hRBCs ( 2.3% hemolysis at 25 ug/ml)|||The hemolytic activity of Megins 1 and Megins 2 on human and rabbit red blood cells was tested. As shown in Table 2, they both exhibited potential hemolytic activity on human and rabbit red blood cells. At concentrations of 25, 50, 100, and 200 μg·mL⁻¹, the hemolysis rates of Megin 1 on human red blood cells were 2.3%, 5.6%, 18.7%, and 29.5%, and on rabbit red blood cells were 3.1%, 7.3%, 20.5%, and 32.9%. The hemolysis rates of Megin 2 on human red blood cells were 3.9%, 13.7%, 27.7%, and 45.3%, and on rabbit red blood cells were 5.6%, 15.2%, 36.2%, and 50.3%. In comparison, Megin 2 exhibited stronger hemolytic activity than Megin 1.|||[Ref.27114317] Human red blood cells: 2.3% hemolysis at 25 ug/ml; 5.6% hemolysis at 50 ug/ml; 18.7% hemolysis at 100 ug/ml; 29.5% hemolysis at 200 ug/ml. Rabbit red blood cells :3.1% hemolysis at 25 ug/ml; 7.3% hemolysis at 50 ug/ml; 20.5% hemolysis at 100 ug/ml; 32.9% hemolysis at 200 ug/ml|||At the concentration of 25, 50, 100, and 200 ug·mL–1, Megin 1 induced 2.3%, 5.6%, 18.7%, and 29.5% human red blood cell hemolysis, respectively, while it induced 3.1, 7.3, 20.5, and 32.9% rabbit blood cell hemolysis, respectively. For Megin 2, the corresponding hemolytic rate was 3.9%, 13.7%, 27.7%, and 45.3% against human red blood cells and 5.6, 15.2, 36.2, and 50.3% against rabbit red blood cells, respectively. Comparatively, Megin 2 showed stronger hemolytic abilities than Megin 1." "Chin J Nat Med. 2016 Apr;14(4):294-8. PubMed|||27114317|||Chin J Nat Med. 2016 Apr;14(4):294-298.||Ref.27114317|||27114317|||Chin J Nat Med . 2016 Apr;14(4):294-298. doi: 10.1016/S1875-5364(16)30030-9.|||Chin J Nat Med. 2016 Apr;14(4):294-298.||Ref.27114317|||Chin J Nat Med. 2016 Apr;14(4):294-8. PubMed" 18 FPDB03317 AP02690|||Megin 2|||DRAMP20785|||Megin 2|||AP02690|||DRAMP20785|||AP02690 FFVLKFLLKWAGKVGLEHLACKFKNWC Anti-E. coli ATCC25922, activity value is MIC = 6.25 ug/ml||Anti-B. dysenteriae, activity value is MIC = 1.5 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 12.5 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC = 1.5 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 12.5 ug/ml||Anti-C.albicans ATCC2002, activity value is MIC = 12.5 ug/ml||Anti-Escherichia coli, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 1.5 ug/ml||Anti-C.albicans, activity value is MIC = 12.5 ug/ml||Anti-##Gram-positive bacteria:Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-##Fungi:C.albicans, activity value is MIC = 12.5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Megophrys minor [Spadefoot toad]|||Amphibian skin|||Megophrys minor [Spadefoot toad]|||skin venoms, spadefoot toad, Megophrys minor, Asia.|||Amphibian skin|||skin venoms, spadefoot toad, Megophrys minor, Asia. N/A "skin venoms, spadefoot toad, Megophrys minor , Asia.||Melittin lysed 99% ofrat red blood cells at a con-centration of25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep-tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 andContig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra-tion (200 ug/ml). Nevertheless, the hemolytic activities ofthe peptides ISGCock_Contig13_4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, andISGCock_Contig15_1337–2 were relatively low compared to that of melittin at a concentration of100 ug/ml.|||hRBCs ( 3.9% hemolysis at 25 ug/ml)|||Megin 1 Hemolytic Value 25 ug · mL¹: human erythrocyte hemolysis rate 2.3%, rabbit erythrocyte hemolysis rate 3.1% 50 ug · mL¹: human erythrocyte hemolysis rate 5.6, rabbit erythrocyte hemolysis rate 7.3 100 ug · mL¹: human erythrocyte hemolysis rate 18.7, rabbit erythrocyte hemolysis rate 20.5 200 ug · mL¹: human erythrocyte hemolysis rate 29.5, rabbit erythrocyte hemolysis rate 32.9 Megin 2 Hemolytic Value 25 ug · mL¹: human erythrocyte hemolysis rate 3.9%, rabbit erythrocyte hemolysis rate 5.6% 50 ug · mL¹: human erythrocyte hemolysis rate 13.7, rabbit erythrocyte hemolysis rate 15.2 100 ug · mL¹: human erythrocyte hemolysis rate 27.7, rabbit erythrocyte hemolysis rate 36.2 200 ug · mL¹: human erythrocyte hemolysis rate 45.3, rabbit erythrocyte hemolysis rate 50.3|||hRBCs ( 3.9% hemolysis at 25 ug/ml)|||The hemolytic activity of Megins 1 and Megins 2 on human and rabbit red blood cells was tested. As shown in Table 2, they both exhibited potential hemolytic activity on human and rabbit red blood cells. At concentrations of 25, 50, 100, and 200 μg·mL⁻¹, the hemolysis rates of Megin 1 on human red blood cells were 2.3%, 5.6%, 18.7%, and 29.5%, and on rabbit red blood cells were 3.1%, 7.3%, 20.5%, and 32.9%. The hemolysis rates of Megin 2 on human red blood cells were 3.9%, 13.7%, 27.7%, and 45.3%, and on rabbit red blood cells were 5.6%, 15.2%, 36.2%, and 50.3%. In comparison, Megin 2 exhibited stronger hemolytic activity than Megin 1.|||[Ref.27114317] Human red blood cells: 3.9% hemolysis at 25 ug/ml; 13.7% hemolysis at 50 ug/ml; 27.7% hemolysis at 100 ug/ml; 45.3% hemolysis at 200 ug/ml;Rabbit red blood cells: 5.6% hemolysis at 25 ug/ml; 15.2% hemolysis at 50 ug/ml; 36.2% hemolysis at 100 ug/ml; 50.3% hemolysis at 200 ug/ml|||At the concentration of 25, 50, 100, and 200 ug·mL–1, Megin 1 induced 2.3%, 5.6%, 18.7%, and 29.5% human red blood cell hemolysis, respectively, while it induced 3.1, 7.3, 20.5, and 32.9% rabbit blood cell hemolysis, respectively. For Megin 2, the corresponding hemolytic rate was 3.9%, 13.7%, 27.7%, and 45.3% against human red blood cells and 5.6, 15.2, 36.2, and 50.3% against rabbit red blood cells, respectively. Comparatively, Megin 2 showed stronger hemolytic abilities than Megin 1." "Chin J Nat Med. 2016 Apr;14(4):294-8. PubMed|||27114317|||Chin J Nat Med. 2016 Apr;14(4):294-298.||Ref.27114317|||27114317|||Chin J Nat Med . 2016 Apr;14(4):294-298. doi: 10.1016/S1875-5364(16)30030-9.|||Chin J Nat Med. 2016 Apr;14(4):294-298.||Ref.27114317|||Chin J Nat Med. 2016 Apr;14(4):294-8. PubMed" 27 FPDB03324 AP02699|||ISGCock_Contig16_2060|||ISGCock_Contig16_2060|||AP02699|||AP02699 ASITHVKNRGKYIYMHLKFRKTNVLI Anti-E. coli ATCC 11775, activity value is MIC = 16 ug/ml||Anti-S. aureus ATCC 25923, activity value is MIC = 16 ug/ml||Anti-and C. albicans ATCC 14053, activity value is MIC = 16 ug/ml||Anti-Escherichia coli ATCC 11775, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 16 ug/ml||Anti-Candida albicans ATCC 14053, activity value is MIC = 16 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Synthetic construct|||Synthetic construct|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals N/A the American Cockroach Periplaneta americana||Melittin lysed 99% ofrat red blood cells at a con-centration of25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep-tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 andContig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra-tion (200 ug/ml). Nevertheless, the hemolytic activities ofthe peptides ISGCock_Contig13_4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, andISGCock_Contig15_1337–2 were relatively low compared to that of melittin at a concentration of108 ug/ml.|||Rat erythrocytes (0% Hemolysis at 200 ug/ml|||Melittin lysed 99% of rat red blood cells at a con centration of 25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 and Contig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra tion (200 ug/ml). Nevertheless, the hemolytic activities of the peptides ISGCock_Contig13_ 4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, and ISGCock_Contig15_13 37–2 were relatively low compared to that of melittin at a concentration of 100 ug/ml. There fore, the ISGCock_Contig05_0593 and Contig16 _4974 peptides are thought to be effective at doses less than 100 ug/ml, indicating their potential as therapeutic agents against a vast array of microbial infections (Fig 4A). "PLoS One. 2016 May 11;11(5):e0155304. PubMed|||27167617|||27167617|||PLoS One . 2016 May 11;11(5):e0155304. doi: 10.1371/journal.pone.0155304. eCollection 2016.|||PLoS One. 2016 May 11;11(5):e0155304. PubMed" 26 FPDB03325 AP02700|||ISGCock_Contig16_4974|||ISGCock_Contig16_4974|||AP02700|||AP02700 KKVWFIFHVCPKLKQRIL Anti-E. coli ATCC 11775, activity value is MIC = 16 ug/ml||Anti-S. aureus ATCC 25923, activity value is MIC = 16 ug/ml||Anti-and C. albicans ATCC 14053, activity value is MIC = 16 ug/ml||Anti-Escherichia coli ATCC 11775, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 16 ug/ml||Anti-Candida albicans ATCC 14053, activity value is MIC = 16 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Synthetic construct|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals N/A the American Cockroach Periplaneta americana|||Rat erythrocytes (0% Hemolysis at 100 ug/ml|||Rat erythrocytes (0% Hemolysis at 100 ug/ml|||Melittin lysed 99% of rat red blood cells at a con centration of 25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 and Contig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra tion (200 ug/ml). Nevertheless, the hemolytic activities of the peptides ISGCock_Contig13_ 4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, and ISGCock_Contig15_13 37–2 were relatively low compared to that of melittin at a concentration of 100 ug/ml. There fore, the ISGCock_Contig05_0593 and Contig16 _4974 peptides are thought to be effective at doses less than 100 ug/ml, indicating their potential as therapeutic agents against a vast array of microbial infections (Fig 4A). "PLoS One. 2016 May 11;11(5):e0155304. PubMed|||27167617|||27167617|||PLoS One . 2016 May 11;11(5):e0155304. doi: 10.1371/journal.pone.0155304. eCollection 2016.|||PLoS One. 2016 May 11;11(5):e0155304. PubMed" 18 FPDB03326 AP02701|||ISGCock_Contig10_4736-2|||ISGCock_Contig10_4736-2|||AP02701|||AP02701 GTKRGKLCRISRLAL Anti-E. coli ATCC 11775, activity value is MIC = 16 ug/ml||Anti-and C. albicans ATCC 14053, activity value is MIC = 32 ug/ml||Anti-Escherichia coli ATCC 11775, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 64 ug/ml||Anti-Candida albicans ATCC 14053, activity value is MIC = 32 ug/ml||Antibacterial||Antifungal||Anti-Gram-||candidacidal Synthetic construct|||Synthetic construct|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals N/A the American Cockroach Periplaneta americana||Melittin caused extensive haemolysis of red blood cells and approx. 90% of cells were haemolysed at a concentration of 372 lgml)1 (Fig. 3). In contrast, melimine did not cause any haemolysis at this concentration. The first appreciable haemolysis of red blood cells by melimine (10%) was observed at a concentration of 2500 lgml)1, and exposure to 5000 lgml)1 melimine resulted in approx. 50% haemolysis (Fig. 3). These concentrations are many times greater than the MICs for melimine. Protamine gave similar results to melimine (Fig. 3).|||Rat erythrocytes (0% Hemolysis at 200 ug/ml|||Melittin lysed 99% of rat red blood cells at a con centration of 25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 and Contig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra tion (200 ug/ml). Nevertheless, the hemolytic activities of the peptides ISGCock_Contig13_ 4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, and ISGCock_Contig15_13 37–2 were relatively low compared to that of melittin at a concentration of 100 ug/ml. There fore, the ISGCock_Contig05_0593 and Contig16 _4974 peptides are thought to be effective at doses less than 100 ug/ml, indicating their potential as therapeutic agents against a vast array of microbial infections (Fig 4A). "PLoS One. 2016 May 11;11(5):e0155304. PubMed|||27167617|||27167617|||PLoS One . 2016 May 11;11(5):e0155304. doi: 10.1371/journal.pone.0155304. eCollection 2016.|||PLoS One. 2016 May 11;11(5):e0155304. PubMed" 15 FPDB03327 AP02702|||Periplanetasin-4|||AP02702 LRHKVYGYCVLGP Anti-E. coli ATCC 11775, activity value is MIC = 64 ug/ml||Anti-and C. albicans ATCC 14053, activity value is MIC = 64 ug/ml||Antifungal||Anti-Gram-||candidacidal Periplaneta americana [American cockroach]|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals N/A the American Cockroach Periplaneta americana||The activity of cathelicidins varies depending upon the peptide composition (4, 14), and even small alterations in the molecule can dramatically alter its properties. For example, SMAP29 shows little hemolytic activity towards human or sheep erythrocytes (14), while SMAP28, with an N-terminal amine, causes hemolysis of human but not sheep erythrocytes (12). In this study, we altered SMAP29 to create a family of 23 related peptides and determined their MICs and minimum bactericidal concentrations (MBCs) for nine ovine pathogens and Aspergillus fumigatus. Polyclonal goat antiserum against SMAP29 and protein G-colloidal gold (PG-CG) was then used to detect SMAP29 on membranes and in the cytoplasm by immunoelectron microscopy.|||Human erythrocytes [0% percent hemolysis at 80 uM]|||Melittin lysed 99% of rat red blood cells at a con centration of 25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 and Contig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra tion (200 ug/ml). Nevertheless, the hemolytic activities of the peptides ISGCock_Contig13_ 4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, and ISGCock_Contig15_13 37–2 were relatively low compared to that of melittin at a concentration of 100 ug/ml. There fore, the ISGCock_Contig05_0593 and Contig16 _4974 peptides are thought to be effective at doses less than 100 ug/ml, indicating their potential as therapeutic agents against a vast array of microbial infections (Fig 4A). "PLoS One. 2016 May 11;11(5):e0155304. PubMed|||30962256|||PLoS One . 2016 May 11;11(5):e0155304. doi: 10.1371/journal.pone.0155304. eCollection 2016.|||PLoS One. 2016 May 11;11(5):e0155304. PubMed" 13 FPDB03328 AP02703|||ISGCock_Contig05_0593|||ISGCock_Contig05_0593|||AP02703|||AP02703 MKTFLRLYRSLINKVLH Anti-E. coli ATCC 11775, activity value is MIC = 4 ug/ml||Anti-S. aureus ATCC 25923, activity value is MIC = 16 ug/ml||Anti-and C. albicans ATCC 14053, activity value is MIC = 4 ug/ml||Anti-Escherichia coli ATCC 11775, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 16 ug/ml||Anti-Candida albicans ATCC 14053, activity value is MIC = 4 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory Synthetic construct|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals N/A the American Cockroach Periplaneta americana|||Rat erythrocytes (0% Hemolysis at 50 ug/ml|||Rat erythrocytes (0% Hemolysis at 50 ug/ml|||Melittin lysed 99% of rat red blood cells at a con centration of 25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 and Contig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra tion (200 ug/ml). Nevertheless, the hemolytic activities of the peptides ISGCock_Contig13_ 4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, and ISGCock_Contig15_13 37–2 were relatively low compared to that of melittin at a concentration of 100 ug/ml. There fore, the ISGCock_Contig05_0593 and Contig16 _4974 peptides are thought to be effective at doses less than 100 ug/ml, indicating their potential as therapeutic agents against a vast array of microbial infections (Fig 4A). "PLoS One. 2016 May 11;11(5):e0155304. PubMed|||27167617|||27167617|||PLoS One . 2016 May 11;11(5):e0155304. doi: 10.1371/journal.pone.0155304. eCollection 2016.|||PLoS One. 2016 May 11;11(5):e0155304. PubMed" 17 FPDB03329 AP02704|||ISGCock_Contig12_4176|||ISGCock_Contig12_4176|||AP02704|||AP02704 VGRKHSILNCIPYLKKKKIMRL Anti-E. coli ATCC 11775, activity value is MIC = 8 ug/ml||Anti-and C. albicans ATCC 14053, activity value is MIC = 8 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 11775, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 64 ug/ml||Anti-Candida albicans ATCC 14053, activity value is MIC = 8 ug/ml||Anti-Gram-||candidacidal Synthetic construct|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals N/A the American Cockroach Periplaneta americana|||Rat erythrocytes (0% Hemolysis at 200 ug/ml|||Rat erythrocytes (0% Hemolysis at 200 ug/ml|||Melittin lysed 99% of rat red blood cells at a con centration of 25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 and Contig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra tion (200 ug/ml). Nevertheless, the hemolytic activities of the peptides ISGCock_Contig13_ 4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, and ISGCock_Contig15_13 37–2 were relatively low compared to that of melittin at a concentration of 100 ug/ml. There fore, the ISGCock_Contig05_0593 and Contig16 _4974 peptides are thought to be effective at doses less than 100 ug/ml, indicating their potential as therapeutic agents against a vast array of microbial infections (Fig 4A). "PLoS One. 2016 May 11;11(5):e0155304. PubMed|||27167617|||27167617|||PLoS One . 2016 May 11;11(5):e0155304. doi: 10.1371/journal.pone.0155304. eCollection 2016.|||PLoS One. 2016 May 11;11(5):e0155304. PubMed" 22 FPDB03336 AP02713|||CZS-1|||DRAMP18453|||CZS-1|||AP02713|||DRAMP18453|||AP02713 GFLDIVKGVGKVALGAVSKLF Active against E. coli (15.1 uM)||S. aureus (3.8 uM)||and C. albicans (3.8 uM).||Anti-E. coli, activity value is MIC = 15.11 uM||Anti-S. aureus, activity value is MIC = 3.77 uM||Anti-C. albicans, activity value is MIC = 3.77 uM||Antimicrobial||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Antiparasitic||Antimalarial Cruziohyla calcarifer|||the splendid leaf frog, Cruziohyla calcarifer, South America|||the splendid leaf frog, Cruziohyla calcarifer, South America N/A "the splendid leaf frog, Cruziohyla calcarifer, South America|||Horse erythrocytes (100% hemolysis at >512 ug/ml)|||CZS-1: Hemolysis rate is 1% at a concentration of 3.77 μM (antibacterial active concentration); 20% at 15.11 μM; and reaches 100% hemolysis at 120.87 μM. • CZS-2: Hemolysis rate is 26% at a concentration of 13.18 μM (antibacterial active concentration); and reaches 100% hemolysis at 210.96 μM. • CZS-3: Hemolysis rate is 6% at a concentration of 13.32 μM (antibacterial active concentration); and reaches 100% hemolysis at 213.33 μM.|||Horse erythrocytes (100% hemolysis at >512 ug/ml)|||No hemolysis information or data found in the reference(s) presented in this entry" "J Proteomics. 2016 Sep 2;146:1-13. PubMed|||27321580|||J Proteomics. 2016 Sep 2;146:1-13.|||27321580|||J Proteomics . 2016 Sep 2:146:1-13. doi: 10.1016/j.jprot.2016.06.017. Epub 2016 Jun 15.|||J Proteomics. 2016 Sep 2;146:1-13.|||J Proteomics. 2016 Sep 2;146:1-13. PubMed" 21 FPDB03337 AP02714|||CZS-2|||DRAMP18452|||CZS-2|||AP02714|||DRAMP18452|||AP02714 GFLDVIKHVGKAALGVVTHLINQ Active against E. coli (26.3 uM)||S. aureus (6.6 uM)||and C. albicans (13.2 uM). Updated 7/2021||Antibacterial||Antifungal||Antimicrobial||Anti-E. coli, activity value is MIC = 26.35 uM||Anti-S. aureus, activity value is MIC = 6.59 uM||Anti-C. albicans, activity value is MIC = 13.18 uM||and C. albicans (13.2 uM).||Anti-Gram+ & Gram-||candidacidal Cruziohyla calcarifer|||the splendid leaf frog, Cruziohyla calcarifer, South America|||the splendid leaf frog, Cruziohyla calcarifer, South America N/A "the splendid leaf frog, Cruziohyla calcarifer, South America|||Horse erythrocytes (100% hemolysis at >512 ug/ml)|||CZS-1: Hemolysis rate is 1% at a concentration of 3.77 μM (antibacterial active concentration); 20% at 15.11 μM; and reaches 100% hemolysis at 120.87 μM. • CZS-2: Hemolysis rate is 26% at a concentration of 13.18 μM (antibacterial active concentration); and reaches 100% hemolysis at 210.96 μM. • CZS-3: Hemolysis rate is 6% at a concentration of 13.32 μM (antibacterial active concentration); and reaches 100% hemolysis at 213.33 μM.|||Horse erythrocytes (100% hemolysis at >512 ug/ml)|||No hemolysis information or data found in the reference(s) presented in this entry" "J Proteomics. 2016 Sep 2;146:1-13. PubMed|||27321580|||J Proteomics. 2016 Sep 2;146:1-13.|||27321580|||J Proteomics . 2016 Sep 2:146:1-13. doi: 10.1016/j.jprot.2016.06.017. Epub 2016 Jun 15.|||J Proteomics. 2016 Sep 2;146:1-13.|||J Proteomics. 2016 Sep 2;146:1-13. PubMed" 23 FPDB03338 AP02715|||CZS-3|||DRAMP18451|||CZS-3|||AP02715|||DRAMP18451|||AP02715 GFLDVVKHIGKAALGAVTHLINQ Active against E. coli (13.3 uM)||S. aureus (13.3 uM)||and C. albicans (13.3 uM). Updated 7/2021||Antibacterial||Antifungal||Antimicrobial||Anti-E. coli, activity value is MIC = 13.32 uM||Anti-S. aureus, activity value is MIC = 13.32 uM||Anti-C. albicans, activity value is MIC = 13.32 uM||and C. albicans (13.3 uM).||Anti-Gram+ & Gram-||candidacidal Cruziohyla calcarifer|||the splendid leaf frog, Cruziohyla calcarifer, South America|||the splendid leaf frog, Cruziohyla calcarifer, South America N/A "the splendid leaf frog, Cruziohyla calcarifer, South America|||Horse erythrocytes (100% hemolysis at 256 ug/ml)|||CZS-1: Hemolysis rate is 1% at a concentration of 3.77 μM (antibacterial active concentration); 20% at 15.11 μM; and reaches 100% hemolysis at 120.87 μM. • CZS-2: Hemolysis rate is 26% at a concentration of 13.18 μM (antibacterial active concentration); and reaches 100% hemolysis at 210.96 μM. • CZS-3: Hemolysis rate is 6% at a concentration of 13.32 μM (antibacterial active concentration); and reaches 100% hemolysis at 213.33 μM.|||Horse erythrocytes (100% hemolysis at 256 ug/ml)|||No hemolysis information or data found in the reference(s) presented in this entry" "J Proteomics. 2016 Sep 2;146:1-13. PubMed|||27321580|||J Proteomics. 2016 Sep 2;146:1-13.|||27321580|||J Proteomics . 2016 Sep 2:146:1-13. doi: 10.1016/j.jprot.2016.06.017. Epub 2016 Jun 15.|||J Proteomics. 2016 Sep 2;146:1-13.|||J Proteomics. 2016 Sep 2;146:1-13. PubMed" 23 FPDB03347 AP02731|||DRAMP18203|||DRAMP18441|||AP02731|||DRAMP18441|||DRAMP18203 SYVGDCGSNGGSCVSSYCPYGNRLNYFCPLGRTCCRRSY Active against E. coli||K. pneumonia||S. aureus||B. subtilis||and C. albicans.||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antifungal||B. subtilisspizizenii||Anti-Gram+ & Gram-||candidacidal the Caribbean spiny lobster, Panulirus genus|||the Caribbean spiny lobster, Panulirus genus Bridge the Caribbean spiny lobster, Panulirus genus|||Panusin also showed no hemolytic effect on human red blood cell "Dev Comp Immunol. 2017 Feb;67:310-321. PubMed|||Dev Comp Immunol. pii: S0145-305X(16)30274-9(2016)|||Dev Comp Immunol. 2017 Feb;67:310-321|||Dev Comp Immunol . 2017 Feb:67:310-321. doi: 10.1016/j.dci.2016.09.002. Epub 2016 Sep 9.|||Dev Comp Immunol. pii: S0145-305X(16)30274-9(2016)|||Dev Comp Immunol. 2017 Feb;67:310-321. PubMed" 39 FPDB03360 AP02760|||ToAP3|||Im-4|||DRAMP18416|||ToAP3|||AP02760|||DRAMP18416|||AP02760 FIGMIPGLIGGLISAIK Anti-Gram+||Antifungal||candidacidal||Anti-C. albicans SC5314, activity value is MIC = 25 uM||Anti-C. tropicalis ATCC 750, activity value is MIC = 12.5 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 100 uM||Anti-C. neoformans H99 serotype A, activity value is MIC = 100 uM||Anti-C. neoformans B3501 serotype D, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 5||Anti-B. subtilis, activity value is MIC = 2.5||Anti-and C. neoformans B3501 serotype D, activity value is MIC = 25 uM onwevev6wv88kr69csrq|||Tityus obscurus|||Isometrus maculatus [Lesser brown scorpion]|||Tityus obscurus Helix "Tityus obscurus|||Sheep red blood cells(EC50 => 30 uM)|||ToAP1, NDBP-4.23: Within the tested concentration range (0.78~100 uM), the hemolysis rate was significantly below 50%, indicating low cytotoxicity and potential value for further study. • NDBP-5.7: At a concentration of 50 uM, the hemolysis rate exceeded 50%, showing relatively high cytotoxicity. • ToAP2: Within the tested concentration range, the hemolysis rate was consistently above 50%, indicating strong cytotoxicity. • ToAP2S1 (ToAP2 modified form): At 25 uM, the hemolysis rate was higher than that of the original peptide ToAP2, and increased hydrophobicity led to enhanced hemolytic activity.|||However,NDBP-5.7presentsahemolysis percent higher than 50% in concentrations up to 50 uM (Figure3D). Comparing the original peptideToAP2 and the modified ToAP2S1, the last one shows a higher hemolysis curve with concentrations up to 25 uM while the ToAP2 maintained its curve above 50%of hemolysis (Figure3A)." "Front Microbiol . 2016 Nov 18:7:1844. doi: 10.3389/fmicb.2016.01844. eCollection 2016.|||27917162|||28941793|||Front Microbiol. 2016 Nov 18;7:1844|||27917162|||Front Microbiol . 2016 Nov 18:7:1844. doi: 10.3389/fmicb.2016.01844. eCollection 2016.|||Front Microbiol. 2016 Nov 18;7:1844. PubMed" 17 FPDB03361 AP02763|||DRAMP18413|||Phylloseptin-PBa|||AP02763|||DRAMP18413 FFSMIPKIAGGIASLVKNLG Anti-S. aureus, activity value is MIC = 8 ug/ml||Anti-E.coli, activity value is MIC = 128 ug/ml||Anti-E. coli, activity value is MIC = 128 ug/ml||Anti-C. albicans, activity value is MIC = 8000 ug/ml||Anti-Gram+||Antifungal||candidacidal the Peruvian Purple-Sided Leaf Frog, Phyllomedusa baltea , South America|||the Peruvian Purple-Sided Leaf Frog, Phyllomedusa baltea , South America N/A "the Peruvian Purple-Sided Leaf Frog, Phyllomedusa baltea , South America||MICs, minimal bactericidal concentrations (MBCs) and haemolytic effects of Phylloseptin-PBa were assessed. Their effects on the Gram-positive bacterium, Staphylococcus aureus, the Gram-negative bacterium, Escherichia coli, and the yeast, Candida albicans, are shown in Table 1. Phylloseptin-PBa exhibited potent antimicrobial activity against Staphylococcus aureus and Candida albicans. More specifically, Phylloseptin-PBa possessed the same MIC values of 8 ug/ml against both organisms, these values being identical to their MBCs (Table 1). Meanwhile, Phylloseptin-PBa showed much weaker antimicrobial activity against Escherichia coli with an MIC value of 128 ug/ml. However, Phylloseptin-PBa was associated with a relatively low cytotoxicity (1.4%) on horse erythrocytes at a concentration of 8 ug/ml, but this rose to around 80% at a concentration of 128 ug/ml (Figure 8).|||At a concentration of 8 ug/ml, the hemolysis rate was only 1.4 (low cytotoxicity, consistent with the MIC values against Staphylococcus aureus and Candida albicans); When the concentration is 16 ug/ml, the hemolysis rate is 1.3; • When the concentration is 32 ug/ml, the hemolysis rate is 1.4; • When the concentration is 64 ug/ml, the hemolysis rate is 5.0; At a concentration of 128 ug/ml, the hemolysis rate increased significantly to about 80% (consistent with the MIC value against E. coli); When the concentration is 256 ug/ml, the hemolysis rate is 38.6; • At a concentration of 512 ug/ml, the hemolysis rate was 104.1%(slightly higher than the positive control).|||Horse blood cells (100% hemolysis at 256 ug/ml)" "Toxins (Basel) . 2015 Dec 1;7(12):5182-93. doi: 10.3390/toxins7124878.|||Toxins (Basel). 2015 Dec 1;7(12):5182-93|||26633506|||Toxins (Basel) . 2015 Dec 1;7(12):5182-93. doi: 10.3390/toxins7124878.|||Toxins (Basel). 2015 Dec 1;7(12):5182-93. PubMed" 20 FPDB03366 AP02770|||Mastoparan-V1|||DRAMP18409|||AP02770|||DRAMP18409|||DRAMP03029|||AP02770 INWKKIKSIIKAAMN Anti-and S. aureus, activity value is MIC = 50 uM||Anti-C. grabrata, activity value is MIC = 50 uM||Anti-and C. neoformans, activity value is MIC = 0.5 uM||Antimicrobial||Antibacterial||Anti-Gram+ & Gram-||Antifungal||candidacidal Vespula vulgaris|||Venom; Social Wasp, Vespula vulgaris|||Venom; Social Wasp, Vespula vulgaris , Europe|||Venom; Social Wasp, Vespula vulgaris|||Vespula vulgaris (Yellow jacket) (Wasp)|||Venom; Social Wasp, Vespula vulgaris , Europe Helix "Venom; Social Wasp, Vespula vulgaris||The hemolytic activity assay was performed as previously described [26] with slight modification. Human red blood cells (RBCs) were used to assess the hemolytic activities of the synthesized venom peptides from the four social wasp species. The RBCs were washed three times for 0.083333 h at 960 rpm with phosphate-buffered saline (PBS) and resuspended to 10% in the same buffer. One hundred microliters of various concentrations (10 to 200 uM) of synthesized peptides were incubated with 0.1 ml of RBCs for 0.5 h at 37 ˝C. After centrifugation for 0.083333 h at 960 rpm, the OD values of the supernatants were measured at 540 nm using a microplate reader (Synergy HT, Bio-Tek Instruments, Inc., Winooski, VT, USA). The relative hemolytic activity was determined by establishing the activity of PBS as 0% and that of 0.1% Trit|||MP-V1: At a concentration of 50 uM, the hemolytic activity on human red blood cells is weak, only 6.6%; when the concentration increases to 100 uM, the hemolytic activity increases to about 20%. • MP-L, MP-X(V), MP-B: In the dose range of 5~100 uM, the hemolytic effect on human red blood cells is very weak, with no significant cytotoxicity (no specific values were given, only stating ""little hemolysis"").|||The mastoparans, synthesized without C-terminal amidation, significantly inhibited the growth of all pathogens listed above (Figures 3 and 4) with little hemolysis on human erythrocytes (Figure 2), indicating that their acidic C-terminus may enhance the bacterial membrane selectivity." "Molecules . 2016 Apr 19;21(4):512. doi: 10.3390/molecules21040512|||P0C1Q8|||Molecules. 2016 Apr 19;21(4):512.|||Genet Mol Res . 2016 Oct 24;15(4). doi: 10.4238/gmr15048859.|||Int Arch Allergy Immunol. 2003 May;131(1):25-32.|||Molecules. 2016 Apr 19;21(4):512. PubMed" 15 FPDB03367 AP02772|||DRAMP18407|||AP02772 KEICCKVPTTPFLCTNDPQCKTLCSKVNYEDGHCFDILSKCVCMNRCVQDAKTLAAELIEEEFLKQ Active against S. cerevisiae||C. albicans||C. tropicalis||E. coli and P. aeruginosa (need be validated using a pure peptide).||Antimicrobial||Antibacterial||Antifungal||Anti-Gram-||candidacidal Fruits, Capsicum annuum|||Fruits, Capsicum annuum Bridge Fruits, Capsicum annuum "Biopolymers . 2014 Jan;102(1):30-9. doi: 10.1002/bip.22351|||Biopolymers. 2014 Jan;102(1):30-9.|||Biopolymers . 2014 Jan;102(1):30-9. doi: 10.1002/bip.22351.|||Biopolymers. 2014 Jan;102(1):30-9. PubMed" 66 FPDB03379 AP02787|||NCR247|||NCR247|||AP02787|||AP02787 RNGCIVDPRCPYQQCRRPLYCRRR Anti-Gram-||Antifungal||candidacidal||Antibacterial||Anti-Escherichia coli ATCC 8739, activity value is MIC = 128 uM||Anti-B. subtilis ATCC 11774, activity value is MIC = 16 uM Medicago truncatula [Barrelclover]|||Medicago truncatula [Barrelclover]|||symbiont bacteria, Medicago truncatula|||symbiont bacteria, Medicago truncatula N/A symbiont bacteria, Medicago truncatula||Various studies pointed out that net charge and positively charged residues significantly affect the antimicrobial activity ofα-helical AMPs (Tossi et al., 2000; Dathe et al., 2001; Giangaspero et al., 2001). Jiang et al. showed that decreasing the net charge on V13K analogs (less than +4) made the peptide inactive, while an increase in net charge from +4 to +8 resulted in higher antimicrobial activity and lower level hemolytic activity.|||Escherichia coli ATCC 8739 ( MIC= 128 uM), B. subtilis ATCC 11774 ( MIC= 16 uM), S. cerevisiae ATCC 9763 ( MIC= >128 uM)|||Jianget al. showed that decreasing the net charge on V13K analogs (less than 4) made the peptide in active,while an increase in net charge from 4 to 8 resulted in higher antimicrobial activity and lower level hemolytic activity. "Front Microbiol . 2017 Jan 23:8:51. doi: 10.3389/fmicb.2017.00051. eCollection 2017.|||30425705, 28167938|||30425705, 28167938|||Front Microbiol . 2017 Jan 23:8:51. doi: 10.3389/fmicb.2017.00051. eCollection 2017.|||Front Microbiol. 2017 Jan 23;8:51. PubMed" 24 FPDB03380 AP02788|||NCR335|||AP02788|||DRAMP18394 RLNTTFRPLNFKMLRFWGQNRNIMKHRGQKVHFSLILSDCKTNKDCPKLRRANVRCRKSYCVPI Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-S. enterica, activity value is MIC = 16 uM||Anti-L. monocytogenes, activity value is MIC = 32 uM Medicago truncatula|||symbiont bacteria, Medicago truncatula|||symbiont bacteria, Medicago truncatula N/A symbiont bacteria, Medicago truncatula||Various studies pointed out that net charge and positively charged residues significantly affect the antimicrobial activity ofα-helical AMPs (Tossi et al., 2000; Dathe et al., 2001; Giangaspero et al., 2001). Jiang et al. showed that decreasing the net charge on V13K analogs (less than +4) made the peptide inactive, while an increase in net charge from +4 to +9 resulted in higher antimicrobial activity and lower level hemolytic activity.|||Jianget al. showed that decreasing the net charge on V13K analogs (less than 4) made the peptide in active,while an increase in net charge from 4 to 8 resulted in higher antimicrobial activity and lower level hemolytic activity. "Front Microbiol . 2017 Jan 23:8:51. doi: 10.3389/fmicb.2017.00051. eCollection 2017.|||https://pubmed.ncbi.nlm.nih.gov/28167938|||Front Microbiol . 2017 Jan 23:8:51. doi: 10.3389/fmicb.2017.00051. eCollection 2017.|||Active against S. enterica (MIC 16 uM) and L. monocytogenes (MIC 32 uM).|||Front Microbiol. 2017 Jan 23;8:51. PubMed" 64 FPDB03437 AP02852|||Rice defensin OsAFP1|||AP02852 RHCLSQSHRFKGMCVSSNNCANVCRTESFPDGECKSHGLERKCFCKKVC Anti-X. oryzae pv. oryzicola, activity value is MIC = 3.9 ug/ml||Anti-E. carotovora, activity value is MIC = 63 ug/ml||Anti-H. oryzae, activity value is MIC = 15 ug/ml||Anti-Candida albicans CAI4, activity value is MIC = 4 uM||Anti-Saccharomyces cerevisiae BY4742, activity value is MIC = 4 uM||Anti-Saccharomyces cerevisiae S288C, activity value is MIC = 16 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal Oryza sativa Japonica Group [Rice]|||rice, Oryza sativa L|||rice, Oryza sativa L Combine Helix and Beta structure rice, Oryza sativa L "Peptides . 2016 Oct:84:7-16. doi: 10.1016/j.peptides.2016.07.005. Epub 2016 Aug 12.||Weerawanich et al., 2018|||30061724|||Peptides . 2016 Oct:84:7-16. doi: 10.1016/j.peptides.2016.07.005. Epub 2016 Aug 12.||Weerawanich et al., 2018|||Peptides. 2016 Oct;84:7-16. doi: 10.1016/j.peptides.2016.07.005. PubMed" 49 FPDB03447 AP02867|||Phylloseptin Co, PS-Co|||AP02867|||Phylloseptin Co, PS-Co|||AP02867 FLSMIPKIAGGIASLVKNL Anti-S. aureus, activity value is MIC = 8 ug/ml||Anti-E.coli, activity value is MIC = 128 ug/ml||Anti-C. albicans, activity value is MIC = 16 ug/ml||Antibacterial ; Synthetic construct||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 8 ug/ml||Anti-Escherichia coli NCTC 10418, activity value is MIC = 128 ug/ml||Anti-Candida albicans NCPF 1467, activity value is MIC = 16 ug/ml||Anti-Gram+||Antifungal||candidacidal||Antibiofilm Synthetic construct|||Phyllomedusa coelestis, South America N/A Phyllomedusa coelestis, South America|||Staphylococcus aureus NCTC 10788[MIC = 8 ug/ml], Escherichia coli NCTC 10418[MIC = 128 ug/ml], Candida albicans NCPF 1467[MIC = 16 ug/ml]||Horse erythrocytes (0% Hemolysis at 16 ug/ml|||Horse erythrocytes (0% Hemolysis at 16 ug/ml|||wermp6brpk76lmapykui|||Horse erythrocytes (0% Hemolysis at 16 ug/ml "Eur J Biochem . 1991 Nov 1;201(3):661-74. doi: 10.1111/j.1432-1033.1991.tb16327.x.|||https://pubmed.ncbi.nlm.nih.gov/27589802|||Toxins (Basel). 2016 Aug 31;8(9). pii: E255. doi: 10.3390/toxins8090255. PubMed|||27589802|||Toxins (Basel) . 2016 Aug 31;8(9):255. doi: 10.3390/toxins8090255.|||Toxins (Basel). 2016 Aug 31;8(9). pii: E255. doi: 10.3390/toxins8090255. PubMed" 19 FPDB03451 AP02876|||CAMPSQ13969|||AP02876|||Dhvar4|||AP02876|||DRAMP04246 KRLFKKLLFSLRKY Anti-and a fluconazole-resistant C. glabrata B57149 isolate, activity value is IC50 = 0.7||Anti-E. coli at 4 ug/ml . S. aureus, activity value is MIC = 16 uM||Anti-B. subtilis, activity value is MIC = 8 uM||Anti-M. luteus, activity value is MIC = 16 uM||Anti-E. coli, activity value is MIC = 32 uM||Anti-P. vulgaris, activity value is MIC = 16 uM||Anti-and P. aeruginosa, activity value is MIC = 32 uM||Anti-10518718: S. aureus, activity value is MIC = 1250 ug/ml||Anti-S. mutans, activity value is MIC = 60 ug/ml||Anti-S. sobrinus, activity value is MIC = 60 ug/ml||Anti-S. salivarius, activity value is MIC = 60 ug/ml||Anti-E. coli, activity value is MIC = 30 ug/ml||Anti-K. pneumoniae, activity value is MIC = 125 ug/ml||Anti-31207076: S. mutans UA159, activity value is MIC = 6.8 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibiofilm||Antibacterial||Antimicrobial Synthetic construct|||sequence truncation, histatin-derived,|||Synthetic construct|||sequence truncation, histatin-derived, Helix sequence truncation, histatin-derived,|||Refer 10338113: hRBC(HC50= >109 uM)|||Refer 10338113: hRBC(HC50= >109 uM) "Antimicrob Agents Chemother . 1999 Mar;43(3):702-4. doi: 10.1128/AAC.43.3.702.||Elving et al., 2000|||16940535, 10338115, 10518718, 31207076||Refer 10338113|||Antimicrob Agents Chemother. 1999 Mar;43(3):702-4. PubMed|||16940535, 10338115, 10518718, 31207076|||Antimicrob Agents Chemother . 1999 Mar;43(3):702-4. doi: 10.1128/AAC.43.3.702.||Elving et al., 2000|||FEMS Microbiol Lett. 1999 Oct 15;179(2):217-222.|||Antimicrob Agents Chemother. 1999 Mar;43(3):702-4. PubMed" 14 FPDB03457 AP02883|||Codesane, COD|||Codesane, COD|||AP02883|||AP02883 GMASLLAKVLPHVVKLIK Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Micrococcus luteus CCM 144, activity value is MIC = 1.7 uM||Anti-Bacillus subtilis 168, activity value is MIC = 2.5 uM||Anti-Staphylococcus aureus, activity value is MIC = 3.7 uM||Anti-Escherichia coli B, activity value is MIC = 3.7 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 31.7 uM||Anti-Candida albicans F7-39/IDE99, activity value is MIC = 25 uM||Anti-M. luteus, activity value is MIC = 1.7 uM||Anti-and C. albicans, activity value is MIC = 25 uM Colletes daviesanus|||venom, wild bee, Colletes daviesanus, Europe|||venom, wild bee, Colletes daviesanus, Europe Helix venom, wild bee, Colletes daviesanus|||Human erythrocytes (50% Hemolysis at 105 uM|||Human erythrocytes (50% Hemolysis at 105 uM|||The toxicity to human red blood cells determined as LC50=105 uM in a hemolytic test was notably high, clearly reflecting its high amphipathic and hydrophobic character (Table 2). "J Pept Sci . 2014 Nov;20(11):885-95.doi: 10.1002/psc.2681.Epub 2014 Aug 14.|||25123582|||25123582|||J Pept Sci . 2014 Nov;20(11):885-95. doi: 10.1002/psc.2681. Epub 2014 Aug 14.|||J Pept Sci. 2014 Nov;20(11):885-95. doi: 10.1002/psc.2681. PubMed" 18 FPDB03469 AP02899|||As-CATH5|||AP02899|||Cathelicidin 5 TRRKFWKKVLNGALKIAPFLLG Active against Gram- bacteria E. coli||S. dysenteriae||K. pneumoniae||K. oxytoca||P. mirabilis||A. baumannii||S. maltophilia||and P. aeruginosa||Gram+ bacteria S. aureus||B. cereus||E. faecium||and S. epidermidis||and fungi C. albicans. Also active against aquatic pathogenic bacteria A. sobria||A. hydrophila||A. veronii||V. harveyi||V. parahaemdyticus||V. anguillarum||and V. cholerae. Antibacterial activity appears to be salt-resistant (salt-insensitive). At a high concentration of 200 ug/ml||it showed only 47% hemolysis (human red blood cells).||Antibacterial||Antiviral ; White spot syndrome virus||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis Alligator sinensis|||Chinese alligator, Alligator sinensis|||Alligator sinensis [Chinese alligator]|||Chinese alligator, Alligator sinensis Helix Chinese alligator, Alligator sinensis||As shown in Table 5, As-CATH4~6 exhibited selective cytotoxicity toward the tested mammalian cells. Among the three tested cells, CHO cell were the most sensitive to As-CATH4~6. At a concentration of 200 ug/ml, As-CATH4~6 induced CHO death rates of 55%, 89% and 89%, respectively. Among the three peptides, As-CATH4 was the least cytotoxic. At a concentration of 200 ug/ml, As-CATH4 induced death rates of 27%, 55% and 17% for BGC-823, CHO and mouse peritoneal macrophages, respectively. As to hemolytic activity, As-CATH4~6 yielded hemolytic rates of 4%, 47%, and 48% respectively toward human erythrocytes. However, it should be noted that the concentrations of As-CATH4~6 in cytotoxic and hemolytic assays were nearly 10-fold higher than their MICs toward most of the tested microorganisms. At a concentration of 20 ug/ml, the cytotoxic and hemolytic rates induced by As-CATH4~6 significantly decreased to below 10%, suggesting their potential in therapeutic application (data not shown). Unlike As-CATH4~6, As-CATH1~4 didn’t show apparent cytotoxic and hemolytic activities (data not shown).|||Aeromonas sobria (MIC=3.67 uM), Aeromonas hydrophila (MIC=3.67 uM), Aeromonas veronii (MIC=3.67 uM), Vibrio harveyi (MIC=3.67 uM), Vibrio parahaemotyticus (MIC=1.83 uM), Vibrio anguillarum (MIC=1.83 uM), Vibrio vulnificus (MIC=3.67 uM), Vibrio splendidus (MIC=1.83 uM), Vibrio splendidus (MIC=1.83 uM), Vibrio cholerae (MIC= 7.33 uM)|||As to hemolytic activity, As-CATH4~6 yielded hemolytic rates of 4%, 47%, and 48% respectively toward human erythrocytes. However, it should be noted that the concentrations of As-CATH4~6 in cytotoxic and hemolytic assays were nearly 10-fold higher than their MICs toward most of the tested microorganisms. At a concentration of 20 ug/ml, the cytotoxic and hemolytic rates induced by As-CATH4~6 significantly decreased to below 10%, suggesting their potential in therapeutic application (data not shown). Unlike As-CATH4~6, As-CATH1~3 didn’t show apparent cytotoxic and hemolytic activities (data not shown). "Biochem J . 2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334.|||29017942|||Biochem J . 2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334.|||31326585|||Biochem J. 2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334. PubMed" 22 FPDB03479 AP02912|||Hl Defensin-1, HlDFS1|||Hl Defensin-1, HlDFS1|||AP02912|||DRAMP32113|||AP02912 GFGCPFNARRCHRHCRSIRRRAGYCAGRLRLTCTCVR activity value is MIC = 90||Anti-M. luteus CMCC28001, activity value is MIC = 10 uM||Anti-M. bovis, activity value is MIC = 0.5 uM||Anti-B. burgdorferi 297-GFP, activity value is MIC = 50 uM||Antibacterial||Antifungal||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||candidacidal Antibacterial, Antifungal|||Synthetic construct|||Haemaphysalis longicornis|||Synthetic|||Haemaphysalis longicornis Bridge Haemaphysalis longicornis||HlDFS1 and HlDFS2 had no significant hemolysis effect on human erythrocytes at low concentrations and did not impair mammalian cell survival. Finally, HlDFS1 and HlDFS2 significantly protected mice against lethal infection by Staphylococcus aureus and Micrococcus luteus.|||Human erythrocytes (<5% Hemolysis at 10 uM|||Human erythrocytes (<5% Hemolysis at 10 uM|||Human erythrocytes: <5% Hemolysis=10 uM; 18% Hemolysis=20 uM; 60% Hemolysis=50 uM|||The results showed that both HlDFS1 and HlDFS2 are harmless to human eryth rocytes in concentrations of up to 10 uM (Fig. 3a). Fur thermore, HlDFS1 and HlDFS2 showed no detectable cytotoxicity to multiple mammalian cell lines, including A549, 293 T, K562 and THP1 cells (Fig. 3b). "Parasit Vectors . 2017 Oct 2;10(1):455. doi: 10.1186/s13071-017-2397-9.|||28969703|||28969703|||Parasit Vectors . 2017 Oct 2;10(1):455. doi: 10.1186/s13071-017-2397-9.|||Parasit Vectors. 2017 Oct 2;10(1):455.|||Parasit Vectors. 2017 Oct 2;10(1):455. doi: 10.1186/s13071-017-2397-9. PubMed" 37 FPDB03487 AP02923|||Andricin B|||DRAMP20966|||Andricin B|||AP02923|||DRAMP20966|||AP02923 GLTRLFSVIK Anti-L. innocua CICC 10417, activity value is MIC = 16.7||Anti-and S. Paratyphi CICC 10437, activity value is MIC = 8.3||Anti-and S. cerevisiae CICC 1002, activity value is MIC = 33.4||Anti-Staphylococcus pseudintermedius MW767056, activity value is MIC = 32 ug/ml||Anti-S. pseudintermedius MW793383, activity value is MIC = 32 ug/ml||Anti-S. pseudintermedius MW793384, activity value is MIC = 128 ug/ml||Anti-S. pseudintermedius MW793385, activity value is MIC = 64 ug/ml||Anti-S. pseudintermedius MW793386, activity value is MIC = 64 ug/ml||Anti-S. pseudintermedius MW793387, activity value is MIC = 128 ug/ml||Anti-S. pseudintermedius MW793388, activity value is MIC = 64 ug/ml||Anti-S. pseudintermedius MW793389, activity value is MIC = 128 ug/ml||Anti-S. pseudintermedius MW793390, activity value is MIC = 128 ug/ml||Anti-S. pseudintermedius MW793391, activity value is MIC = 32 ug/ml||Anti-S. pseudintermedius MW793392, activity value is MIC = 64 ug/ml||Anti-S. pseudintermedius MW767046, activity value is MIC = 32 ug/ml||Anti-Staphylococcus cohnii MW767053, activity value is MIC = 64 ug/ml||Anti-Staphylococcus simulans MW767052, activity value is MIC = 256 ug/ml||Anti-Microsporum canis MW767025, activity value is MIC = 1 ug/ml||Anti-M. canis MW767026, activity value is MIC = 0.5 ug/ml||Anti-M. canis MW767027, activity value is MIC = 1 ug/ml||Anti-M. canis MW768151, activity value is MIC = 1 ug/ml||Anti-Trichophyton mentagrophytes MW766984, activity value is MIC = 1 ug/ml||Anti-Microsporum gypseum MW766983, activity value is MIC = 32 ug/ml||Anti-Bacillus subtilis CICC 10034, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus CICC10306, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus CICC 10384, activity value is MIC = 16 ug/ml||Anti-Listeria innocua CICC 10417, activity value is MIC = 32 ug/ml||Anti-Escherichia coli CICC10293, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa CICC 21636, activity value is MIC = 8 ug/ml||Anti-Serratia marcescens ATCC 4112, activity value is MIC = 8 ug/ml||Anti-Enterobacter cloacae CICC 21539, activity value is MIC = 16 ug/ml||Anti-Salmonella paratyphi CICC 10437, activity value is MIC = 32 ug/ml||Anti-Aspergillus niger CICC 2124, activity value is MIC = 64 ug/ml||Anti-Candida albicans CICC 1965, activity value is MIC = 32 ug/ml||Anti-Saccharomyces cerevisiae CICC 1002, activity value is MIC = 64 ug/ml||activity value is MBC = 32 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli CICC10293, activity value is MIC = 16 ug/ml||activity value is MBC = 16 ug/ml||Anti-##Fungi : Aspergillus niger CICC 2124, activity value is MIC = 64 ug/ml||activity value is MBC = 64 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Synthetic construct|||Andrias davidianus|||Synthetic construct|||blood, Chinese giant salamander, Andrias davidianus|||Andrias davidianus|||blood, Chinese giant salamander, Andrias davidianus Random coil "blood, Chinese giant salamander, Andrias davidianus||The hemolytic activities of andricin B are shown in Fig. 2. At the MIC, the hemolysis levels are almost similar to the basal levels. These data demonstrate that andricin B has very little cytotoxicity near its MIC. Generally, the antimicrobial peptides exhibiting no/low hemolytic activity are considered for practical applications (Tang et al., 2014). For example, Ma reported that the antimicrobial peptide from swine blood was able to induce 2.4% hemolysis at the MICs (Ma et al., 2010). Bu also reported that the antimicrobial peptides from Kulun donkey blood were able to safely treat bovine mastitis (Bu et al., 2011).|||sheep RBCs and Mouse RBCs, 5% hemolysis at 128 ug/ml|||- Test conditions: Human red blood cells, negative control (10 mmol PBS, pH 7.2) showed 0% hemolysis, positive control (0.1% Triton X-100) showed 100% hemolysis. - Novel antimicrobial peptide Andricin B: At its minimum inhibitory concentration (MIC, 8–64 µg/ml), the level of hemolysis was almost identical to the baseline (negative control), showing no significant hemolytic activity and good safety. - Additional background: The MIC range of Andricin B is 8–64 µg/ml (corresponding to 8.3–66.8 µM), and it exhibits inhibitory effects on Gram-positive bacteria, Gram-negative bacteria, and some fungi. Its low hemolytic activity gives it potential for practical applications.|||Ma reported that antimicrobial peptides from pig blood can induce 2.4% hemolysis in MICS.|||[Ref.29130500] 0% hemolysis at 64 ug/ml , 0.5% hemolysis at 128 ug/ml , 2% hemolysis at 256 ug/ml , 13% hemolysis at 512 ug/ml against human red blood cells|||The hemolytic activities of andricin B are shown in Fig. 2. At the MIC, the hemolysis levels are almost similar to the basal levels. These data demonstrate that andricin B has very little cytotoxicity near its MIC. Generally, the antimicrobial peptides exhibiting no/low hemolytic activity are considered for practical applications (Tang et al., 2014). For example, Ma reported that the antimicrobial peptide from swine blood was able to induce 2.4% hemolysis at the MICs (Ma et al., 2010)." "Lett Appl Microbiol . 2018 Jan;66(1):38-43. doi: 10.1111/lam.12823. Epub 2017 Dec 11.|||34456884|||Lett Appl Microbiol.?2018 Jan;66(1):38-43. doi: 10.1111/lam.12823.||Ref.29130500|||https://pubmed.ncbi.nlm.nih.gov/34456884|||Lett Appl Microbiol . 2018 Jan;66(1):38-43. doi: 10.1111/lam.12823. Epub 2017 Dec 11.|||Lett Appl Microbiol.?2018 Jan;66(1):38-43. doi: 10.1111/lam.12823.||Ref.29130500|||Lett Appl Microbiol. 2018 Jan;66(1):38-43. doi: 10.1111/lam.12823. PubMed" 10 FPDB03517 AP02958|||Brevinin-2Ta|||Brevinin-2Ta|||AP02958|||DRAMP01908|||AP02958 GILDTLKNLAKTAGKGILKSLVNTASCKLSGQC Anti-Broadly active against S. aureus, activity value is MIC = 20 uM||Anti-E. coli, activity value is MIC = 10 uM||Antibacterial||Antifungal||Anti-S. aureus, activity value is MIC = 64 ug/ml||Anti-E. coli, activity value is MIC = 32 ug/ml||Anti-C. albicans, activity value is MIC = 64 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 64 ug/ml||Antimicrobial||Anti-Gram+ & Gram-||candidacidal||Anti-inflammatory||Wound healing Pelophylax kl. esculentus|||Pelophylax kl. esculentus|||Pelophylax kl. esculentus, Europe|||Rana temporaria (European common frog)|||Pelophylax kl. esculentus, Europe N/A Pelophylax kl. esculentus, Europe||The data obtained from minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) assays on the synthetic peptide B-2Ta were compared to those of melittin and ampicillin [7] (Table 1). MICs of B-2Ta were 64 ug/ml (20 uM) against S. aureus, 32 ug/ml (10 uM) against E. coli, and 64 ug/ml (20 uM) against C. albicans. As a well-defined broad-spectrum antibacterial honey bee venom peptide, melittin possessed distinct cytotoxicity (>70% haemolysis) at the MICs. Ampicillin exhibited strong effects against S. aureus (0.0625 ug/ml) and E. coli (0.125 ug/ml), whereas it was ineffective towards C. albicans. The MBCs of the natural peptides, B-2Ta and melittin, were found to be two-fold higher compared with their MICs. However, MBCs of ampicillin against S. aureus and E. coli were 256 and 64-fold increase over the MICs, respectively. The haemolytic effect of B-2Ta are shown in Figure 3B, it displayed that 60% of horse blood erythrocytes were lysed at the maximal concentration of peptide (512 ug/ml), while the peptide possessed only low level of haemolysis (<10%) at the MICs against S. aureus, E. coli and C. albicans (Table 1). eanwhile, the antimicrobial assessment of B-2Ta against K. pneumoniae in vitro showed that the MIC value was 64 ug/ml, and IC50 value was 38.1 ug/ml (Figure 3A).|||Horse RBCs (60% hemolysis at 512 ug/ml)|||Horse RBCs (60% hemolysis at 512 ug/ml) "Oncotarget . 2017 Nov 30;8(67):111369-111385. doi: 10.18632/oncotarget.22797. eCollection 2017 Dec 19.|||29340060|||29340060|||Oncotarget . 2017 Nov 30;8(67):111369-111385. doi: 10.18632/oncotarget.22797. eCollection 2017 Dec 19.|||Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.|||Oncotarget. 2017 Nov 30;8(67):111369-111385. doi: 10.18632/oncotarget.22797. PubMed" 33 FPDB03533 AP02989|||Phylloseptin-1.1TR|||Phylloseptin-1.1TR|||AP02989|||DRAMP01289|||AP02989 FLSLIPKIAGGIASLVKNL Anti-E. coli, activity value is MIC = 25 uM||Anti-S. epidermidis, activity value is MIC = 6.25 uM||Anti-and C. albicans, activity value is MIC = 50 uM||Anti-S. epidermis, activity value is MIC = 6.25 uM||Anti-C. albicans, activity value is MIC = 50 uM||Antimicrobial||Anti-Gram+ & Gram-||Antifungal||candidacidal Phyllomedusa trinitatis [Trinidad leaf frog ]|||Trinidadian leaf frog, Phyllomedusa trinitatis,|||Phyllomedusa tarsius (Brownbelly leaf frog) (Phyllomedusa tarsia)|||Trinidadian leaf frog, Phyllomedusa trinitatis, N/A Trinidadian leaf frog, Phyllomedusa trinitatis, "Comp Biochem Physiol Part D Genomics Proteomics . 2018 Dec:28:72-79.doi: 10.1016/j.cbd.2018.06.006.Epub 2018 Jun 30.|||29980138|||29980138|||Comp Biochem Physiol Part D Genomics Proteomics . 2018 Dec:28:72-79. doi: 10.1016/j.cbd.2018.06.006. Epub 2018 Jun 30.|||Submitted (AUG-2006) to UniProtKB|||Comp Biochem Physiol Part D Genomics Proteomics. 2018 Jun 30;28:72-79. doi: 10.1016/j.cbd.2018.06.006. PubMed" 19 FPDB03534 AP02990|||Phylloseptin-1.2TR|||Phylloseptin-1.2TR|||AP02990|||AP02990 FLSLIPKIAGGIASLVKDL Anti-E. coli, activity value is MIC = 100 uM||Anti-S. epidermidis, activity value is MIC = 100 uM||Anti-and C. albicans, activity value is MIC = 100 uM||Anti-S. epidermis, activity value is MIC = 100 uM||Anti-C. albicans, activity value is MIC = 100 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal Phyllomedusa trinitatis [Trinidad leaf frog ]|||Trinidadian leaf frog, Phyllomedusa trinitatis,|||Trinidadian leaf frog, Phyllomedusa trinitatis, N/A Trinidadian leaf frog, Phyllomedusa trinitatis, "Comp Biochem Physiol Part D Genomics Proteomics . 2018 Dec:28:72-79.doi: 10.1016/j.cbd.2018.06.006.Epub 2018 Jun 30.|||29980138|||29980138|||Comp Biochem Physiol Part D Genomics Proteomics . 2018 Dec:28:72-79. doi: 10.1016/j.cbd.2018.06.006. Epub 2018 Jun 30.|||Comp Biochem Physiol Part D Genomics Proteomics. 2018 Jun 30;28:72-79. doi: 10.1016/j.cbd.2018.06.006. PubMed" 19 FPDB03535 AP02991|||Phylloseptin-2.1TR|||Phylloseptin-2.1TR|||AP02991|||DRAMP01290|||AP02991 FLSLIPHIATGIAALAKHL Anti-E. coli, activity value is MIC = 50 uM||Anti-S. epidermidis, activity value is MIC = 12.5 uM||Anti-and C. albicans, activity value is MIC = 100 uM||Anti-S. epidermis, activity value is MIC = 12.5 uM||Anti-C. albicans, activity value is MIC = 100 uM||Antimicrobial||Anti-Gram+ & Gram-||Antifungal||candidacidal Phyllomedusa trinitatis [Trinidad leaf frog ]|||Trinidadian leaf frog, Phyllomedusa trinitatis,|||Phyllomedusa tarsius (Brownbelly leaf frog) (Phyllomedusa tarsia)|||Trinidadian leaf frog, Phyllomedusa trinitatis, N/A Trinidadian leaf frog, Phyllomedusa trinitatis, "Comp Biochem Physiol Part D Genomics Proteomics . 2018 Dec:28:72-79. doi: 10.1016/j.cbd.2018.06.006. Epub 2018 Jun 30.|||29980138|||29980138|||Comp Biochem Physiol Part D Genomics Proteomics . 2018 Dec:28:72-79. doi: 10.1016/j.cbd.2018.06.006. Epub 2018 Jun 30.|||Submitted (AUG-2006) to UniProtKB|||Comp Biochem Physiol Part D Genomics Proteomics. 2018 Jun 30;28:72-79. doi: 10.1016/j.cbd.2018.06.006. PubMed" 19 FPDB03536 AP02992|||Phylloseptin-3.1TR|||Phylloseptin-3.2TR|||Phylloseptin-3.1TR|||Phylloseptin-3.2TR|||AP02992|||DRAMP01291|||AP02992 FFSMIPKIATGIASLVKNL Anti-E. coli, activity value is MIC = 100 uM||Anti-S. epidermidis, activity value is MIC = 12.5 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Anti-S. epidermis, activity value is MIC = 12.5 uM||Anti-C. albicans, activity value is MIC = 25 uM||Anti-E. coli, activity value is MIC > 100 uM||Anti-S. epidermis, activity value is MIC > 100 uM||Anti-C. albicans, activity value is MIC = 100 uM||Antimicrobial||Anti-Gram+ & Gram-||Antifungal||candidacidal Phyllomedusa trinitatis [Trinidad leaf frog ]|||Trinidadian leaf frog, Phyllomedusa trinitatis, also skin secretions, Phyllomedusa duellmani, South America|||Phyllomedusa tarsius (Brownbelly leaf frog) (Phyllomedusa tarsia)|||Trinidadian leaf frog, Phyllomedusa trinitatis, also skin secretions, Phyllomedusa duellmani, South America N/A Trinidadian leaf frog, Phyllomedusa trinitatis, also skin secretions, Phyllomedusa duellmani, South America||Synthetic PS-Du and PS-Co and their respective structurally-modified analogues, PS-Du K7H and PS-Co K7H, exhibited growth inhibitory activity against the Gram-positive bacterium, S. aureus, the Gram-negative bacterium, E. coli and the potentially-pathogenic yeast, C. albicans. MICs (minimal inhibitory concentrations）of all four peptides are summarised in Table 1 and MIC curves are shown in Figure 9. The skin secretion-derived peptides, PS-Du and PS-Co, showed similar potencies with MIC values of 8 ug/ml against S. aureus, 128 ug/ml against E. coli and 16 ug/ml against C. albicans. The modified peptide analogues, PS-Du K7H and PS-Co K7H, showed similar inhibition with MIC values of 32 ug/ml towards S. aureus, 512 ug/ml towards E. coli and 64 ug/ml towards C. albicans. Both natural peptides, PS-Du and PS-Co, and modified peptides, PS-Du K7H and PS-Co K7H, exhibited moderate haemolytic effects on horse red blood cells as shown in Figure 10. "Toxins (Basel) . 2016 Aug 31;8(9):255.doi: 10.3390/toxins8090255.|||29980138|||29980138|||Toxins (Basel) . 2016 Aug 31;8(9):255. doi: 10.3390/toxins8090255.|||Submitted (AUG-2006) to UniProtKB|||Toxins (Basel). 2016 Aug 31;8(9). pii: E255. doi: 10.3390/toxins8090255. PubMed" 19 FPDB03572 AP03051|||DRAMP35648 KKPSKKPKPQAMTFPKVTVEYFPASFSTAALTVPED Anti-Gram- E. coli ATCC25922 or IS series, activity value is MIC = 18.75||Anti-D.bacillus IS, activity value is MIC > 200 ug/ml||Anti-K. pneumoniae IS sereis, activity value is MIC = 37.5||Anti-K. oxytoca IS, activity value is MIC = 75 ug/ml||Anti-P.vulgaris, activity value is MIC > 200 ug/ml||Anti-P.mirabilis IS, activity value is MIC > 200 ug/ml||Anti-A.baumannii, activity value is MIC > 200 ug/ml||Anti-S. maltophilia IS 7404, activity value is MIC = 75 ug/ml||Anti-S.maltophilia IS 090223, activity value is MIC > 200 ug/ml||Anti-P.aeruginosa ATCC 27853 IS 1411, activity value is MIC > 200 ug/ml||Anti-P. aeruginosa, activity value is MIC = 37.5 ug/ml||Anti-S.paratyphi, activity value is MIC > 200 uM||Anti-IS 08032XXX series, activity value is MIC > 200 ug/ml||Anti-S. aureus IS1307, activity value is MIC = 75 ug/ml||Anti-B.subtilis IS, activity value is MIC > 200 ug/ml||Anti-E.faecium, activity value is MIC > 200 ug/ml||Anti-N.asteroids, activity value is MIC > 200 ug/ml||Anti-E.faecalis IS981, activity value is MIC > 200 ug/ml||Anti-S.epidermidis, activity value is MIC > 200 ug/ml||Anti-C. albicans IS 8022821 or 08030809, activity value is MIC = 37.5||Anti-C.albicans IS 08022821, activity value is MIC > 200 ug/ml||Anti-A.cinerea, activity value is MIC > 200 ug/ml||Anti-C.glabrata IS 08A802, activity value is MIC > 200 ug/ml||Anti-V.cholerae, activity value is MIC > 200 ug/ml||Anti-E.tarda, activity value is MIC > 200 ug/ml||Anti-A.hydrophila, activity value is MIC > 200 ug/ml||Anti-and A.veronii, activity value is MIC > 200 ug/ml||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||candidacidal Animalia|||turtle, Pelodiscus sinensis Helix turtle, Pelodiscus sinensis|||Hemolytic assay indicated that Ps-CATH4 and 6 only induced 4.35% and 2.98% hemolysis of human erythrocytes, respectively (Table 7). "Dev Comp Immunol . 2019 Mar:92:179-192. doi: 10.1016/j.dci.2018.11.010. Epub 2018 Nov 16.|||Dev Comp Immunol. 2019 Mar;92:179-192.|||Dev Comp Immunol. 2019 Mar;92:179-192. doi: 10.1016/j.dci.2018.11.010. PubMed" 36 FPDB03578 AP03062 FLGSIIGALAKGLPSLIALIKK Anti-Gram+ S. aureus, activity value is MIC = 27 uM||Anti-B. cereus, activity value is MIC = 6.8 uM||Anti-and fungi C. albicans, activity value is MIC = 27 uM||Anti-Gram+||Antifungal||candidacidal Skin, Ryukyu Brown Frog, Rana ulma, Asia|||Skin, Ryukyu Brown Frog, Rana ulma, Asia N/A Skin, Ryukyu Brown Frog, Rana ulma, Asia||Compared with the hemolytic activity of 0.1% Triton X-100, brevinin 1ULf at 32, 64, and 128 µg/ml induced 13.1%, 54.7%, and 90.1% hemolysis, respectively.|||Current hemolysis assays show that, compared to 0.1% Triton X-100, Brevinin1ULf at 32 and 128 ug/ml had hemolytic rates of 13.1%, 54.7%, and 90.1%, respectively. At all concentrations examined, Ulmin-1ULa exhibited weak but significant hemolytic activity. Similar to the hemolysis results, COS7 cells treated with Luminin-1ULf had significantly reduced survival at 32 ug/ml (a 12.8% decrease compared to the control group), and below 3.5% at higher concentrations (Figure 8). In the same detection system, when concentrations exceeded 32 ug/ml, UMIN-1ULa-induced cell viability significantly decreased.|||The present hemolytic assays showed that brevinin 1ULf induced 13.1%, 54.7%, and 90.1% hemolysis at 32, 64, and 128 ug/ml, respectively, when compared with the hemo lytic activity of 0.1% Triton X-100 (Fig. 7). Ulmin-1ULa showed a weak but significant hemolytic activity at all of the concentra tions examined. "Zoolog Sci . 2017 Dec;34(6):523-531. doi: 10.2108/zs170084.|||Zoolog Sci. 2017 Dec;34(6):523-531. doi: 10.2108/zs170084. PubMed" 22 FPDB03582 AP03072|||Flower-specific gamma-thionin, ZmD32|||AP03072|||DRAMP35665 RTCQSQSHRFRGPCLRRSNCANVCRTEGFPGGRCRGFRRRCFCTTHC Anti-the filamentous fungus F. graminearum and E. coli in media containing 100000 uM NaCl . Other fungi inhibited are C. auris, activity value is IC50 = 3.4 uM||Anti-C. glabrata ATCC 90030, activity value is IC50 = 1.2 uM||Anti-C. krusei, activity value is IC50 = 0.9 uM||Anti-C. parapsilosis, activity value is IC50 = 1.3 uM||Anti-C. tropicalis ATCC 750, activity value is IC50 = 0.5 uM||Anti-F. graminearum PH-1, activity value is IC50 = 1 uM||Anti-S. aureus ATCC 9144, activity value is IC50 = 1.5 uM||Anti-B. subtilis, activity value is IC50 = 0.4 uM||Anti-and P. aeruginosa PAO1, activity value is IC50 = 1.7 uM||Anti-Candida albicans ATCC 90028, activity value is IC50 = 1.1||Anti-Candida albicans ATCC 90028, activity value is IC50 = 3.0||Anti-Candida auris, activity value is IC50 = 3.4||Anti-Candida auris, activity value is IC50 = 1.6||Anti-Candida glabrata ATCC 90030, activity value is IC50 = 1.2||Anti-Candida glabrata ATCC 90030, activity value is IC50 = 2.0||Anti-Candida krusei, activity value is IC50 = 0.9||Anti-Candida krusei, activity value is IC50 = 1.7||Anti-Candida parapsilosis, activity value is IC50 = 1.3||Anti-Candida parapsilosis, activity value is IC50 = 1.5||Anti-Candida tropicalis ATCC 750, activity value is IC50 = 0.5||Anti-Candida tropicalis ATCC 750, activity value is IC50 = 0.7||Anti-Fusarium graminearum PH-1, activity value is IC50 = 1.0||Anti-Escherichia coli, activity value is IC50 = 1||Anti-Escherichia coli, activity value is IC50 = 0.3||Anti-Staphylococcus aureus ATCC 9144, activity value is IC50 = 1.5||Anti-Bacillus subtilis, activity value is IC50 = 0.4||Anti-Pseudomonas aeruginosa PAO1, activity value is IC50 = 1.7||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibiofilm||Antimicrobial||Anticancer Zea mays|||Corn, Zea mays|||Plantae|||Corn, Zea mays Combine Helix and Beta structure "Corn, Zea mays|||Human dermal fibroblasts (30% Killing at 50 uM|||The document explicitly provides hemolysis data of the corn defensin ZmD32 on human red blood cells, with the core information as follows: Hemolytic values of ZmD32 The hemolysis of this defensin was measured by the hemolysis rate of human red blood cells at different concentrations, with the specific results as follows: At the highest tested concentration (50 μM): only 1.9% of human red blood cells were lysed, indicating very low hemolysis. Control comparison: recombinant NaD1 (another plant defensin) showed a hemolysis rate of about 1.5% at the same concentration (50 μM). The hemolysis of ZmD32 is similar to that of NaD1, both showing low toxicity to human red blood cells. The experiment used water-lysed red cells as the 100% hemolysis positive control, and the hemolysis rate was calculated by measuring absorbance at 412 nm (Figure 4D). The data represent the average results from samples of six blood donors, further confirming the safety of ZmD32 on mammalian red blood cells.|||Hemolytic activity of ZmD32 and NaD1. Neither defensin lysed more than 2 % of red blood cells at 334 concentrations up to 50 uM." "Front Microbiol . 2019 Apr 12:10:795. doi: 10.3389/fmicb.2019.00795. eCollection 2019|||31031739|||Front Microbiol. 2019 Apr 12;10:795. doi: 10.3389/fmicb.2019.00795. PubMed|||Front Microbiol . 2019 Apr 12:10:795. doi: 10.3389/fmicb.2019.00795. eCollection 2019.|||Front Microbiol. 2019 Apr 12;10:795.|||Front Microbiol. 2019 Apr 12;10:795. doi: 10.3389/fmicb.2019.00795. PubMed" 47 FPDB03586 AP03077|||Cathelicidin SA-CATH|||AP03077|||Cathelicidin SA-CATH|||AP03077 KFFKKLKKSVKKHVKKFFKKPKVIGVSIPF Anti-Gram- E. coli ATCC25922 or clinical strain, activity value is MIC = 5.22||Anti-S. dysenteriae clinical strain, activity value is MIC = 10.44 uM||Anti-K. peneumoniae clinical strain, activity value is MIC = 10.44 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10.44 uM||Anti-S. aureus ATCC25923, activity value is MIC = 20.88 uM||Anti-B. cereus clinical strain, activity value is MIC = 1.3 uM||Anti-B. subtilis clinical strain, activity value is MIC = 5.22 uM||Anti-E. faecium clinical strain, activity value is MIC = 10.44 uM||Anti-N. asteroides clinical strain, activity value is MIC = 10.4 uM||Anti-C. albicans, activity value is MIC = 5.22||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Anti-inflammatory||Antibiofilm||Anti-Escherichia coli ATCC 25922, activity value is MIC = 18.75 ug/ml||Anti-Escherichia coli, activity value is MIC = 75 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 37.5 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 37.5 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 37.5 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 75 ug/ml||Anti-Bacillus cereus, activity value is MIC = 4.69 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 18.75 ug/ml||Anti-Enterococcus faecium, activity value is MIC = 37.5 ug/ml||Anti-Nocardia asteroides, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans 1, activity value is MIC = 37.5 ug/ml||Anti-Candida albicans, activity value is MIC = 18.75 ug/ml||Anti-Candida glabrata, activity value is MIC = 37.5 ug/ml Sinonatrix annularis (Trimerodytes annularis)|||snake, Sinonatrix annularis, China, Asia|||Sinonatrix annularis (Trimerodytes annularis)|||snake, Sinonatrix annularis, China, Asia|||snake, Sinonatrix annularis, China, Asia N/A "snake, Sinonatrix annularis, China, Asia||At a concentration of 200 µg/ml, the hemolysis rate induced by SA-CATH was 5.12%|||Murine peritoneal macrophages (3.45% Killing at 200 ug/ml|||The document clearly provides hemolytic data of the novel cathelicidin SA-CATH, derived from the black-banded krait (Sinonatrix annularis), on human red blood cells. The core information is as follows: Hemolytic values of SA-CATH The hemolytic activity of this cathelicidin was measured by the hemolysis rate of human red blood cells at different concentrations. The specific results are: At the highest tested concentration (200 µg/ml): it caused only 5.12% hemolysis of human red blood cells, indicating very low hemolytic activity. Control comparison: the experiment used 1% Triton X-100 as a 100% hemolysis positive control and 0.9% saline as a negative control, and hemolysis rates were calculated by measuring absorbance at 540 nm. At this concentration, SA-CATH also showed very low cytotoxicity to mammalian cells (mouse peritoneal macrophages MPMs and human keratinocytes HaCaT), with cell death rates of 3.45% and 4.76%, respectively, further confirming its safety for mammalian cells.|||Murine peritoneal macrophages (3.45% Killing at 200 ug/ml|||The cytotoxicity and hemolytic activity of A-Cath and SA-Cath against tested mammalian cells are negligible. At a concentration of 200 μg/ml, SA-Cath induced cell death rates of 3.45% and 4.76% in MPM and HaCaT cells, respectively. Similarly, SA-Cath exhibited very low hemolytic activity against human erythrocytes. At a concentration of 200 μg/ml, the hemolysis rate of SA-Cath was 5.12%.|||SA-CATH shown very low hemolytic activity toward human erythrocytes. At the con centration of 200 ug/ml, SA-CATH induced hemolytic rate of 5.12%." "Zoolog Sci . 2019 Feb 1;36(1):68-76. doi: 10.2108/zs180064.|||31116540|||Zoolog Sci. 2019 Feb;36(1):68-76. doi: 10.2108/zs180064. PubMed|||31116540|||Zoolog Sci . 2019 Feb 1;36(1):68-76. doi: 10.2108/zs180064.|||Zoolog Sci. 2019 Feb;36(1):68-76. doi: 10.2108/zs180064. PubMed" 30 FPDB03587 AP03078|||Cm-CATH1|||AP03078 RRSIFRKLRRKIKKGLKKGIQHLLAGGRQGLPQGGRPGMI Anti-Gram- E. coli ATCC25922, activity value is MIC = 9.3 ug/ml||Anti-some clinical strains, activity value is MIC = 4.69||Anti-K. Pneumoniae, activity value is MIC = 75||Anti-S. maltophilia, activity value is MIC = 9.38 ug/ml||Anti-P. aeruginosa clinical strain, activity value is MIC = 4.69 ug/ml||Anti-S. aureus clinical strains, activity value is MIC = 18.75||Anti-B. cereus, activity value is MIC = 75 ug/ml||Anti-B. subtilis, activity value is MIC = 18.75 ug/ml||Anti-N. asteroides, activity value is MIC = 4.69 ug/ml||Anti-C. albicans, activity value is MIC = 1.17||Anti-aquatic pathogens V. brasiliensis, activity value is MIC = 18.7 ug/ml||Anti-A. veronii, activity value is MIC = 75 ug/ml||Anti-E. tarda, activity value is MIC = 18.75 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Chelonia mydas|||lung, green sea turtle, Chelonia mydas|||lung, green sea turtle, Chelonia mydas N/A lung, green sea turtle, Chelonia mydas||Cm-CATH 2 exhibits low hemolytic activity, inducing 2.05%, 7.91%, 10.53%, and 12.2% hemolysis of human red blood cells at concentrations of 10, 50, 100, and 150 μg/ml, respectively.|||Therefore, this study also measured the hemolytic activity of CM-CATH2. CM-CATH2 has relatively low hemolytic activity, with lysis rates of human red blood cells at 10, 50, 100, and 150 µg/ml being 2.05%, 7.91%, 10.53%, and 12.2%, respectively.|||Many cathelicidins exhibit relatively high hemolytic activities, which significantly limit their clinical applications. Therefore, in the present study the hemolytic activity of Cm-CATH2 was also determined. Cm-CATH2 displayed low hemolytic activity, inducing the lysis of 2.05%, 7.91%, 10.53% and 12.2% of human erythrocytes at 10, 50, 100 and 150 ug/ml, respectively. "Dev Comp Immunol . 2019 Sep:98:189-204. doi: 10.1016/j.dci.2019.05.005. Epub 2019 May 20.|||31121185|||Dev Comp Immunol . 2019 Sep:98:189-204. doi: 10.1016/j.dci.2019.05.005. Epub 2019 May 20.|||Dev Comp Immunol. 2019 May 20;98:189-204. doi: 10.1016/j.dci.2019.05.005. PubMed" 40 FPDB03588 AP03079|||Cm-CATH2|||AP03079|||Cm-CATH2|||AP03079|||DRAMP35666|||DRAMP35667 RRSRFGRFFKKVRKQLGRVLRHSRITVGGRMRF Anti-E. coli ATCC25922 and clinical strains, activity value is MIC = 4.69||Anti-S. dysenteriae, activity value is MIC = 1.17 ug/ml||Anti-K. Pneumoniae, activity value is MIC = 9.38||Anti-S. maltophilia, activity value is MIC = 18.7 ug/ml||Anti-K. oxytoca, activity value is MIC = 18.75 ug/ml||Anti-P. vulgaris, activity value is MIC = 18.75 ug/ml||Anti-P. mirabilis, activity value is MIC = 18.75 ug/ml||Anti-A. baumannii, activity value is MIC = 18.75 ug/ml||Anti-S. maltophilia, activity value is MIC = 18.75 ug/ml||Anti-P. aeruginosa, activity value is MIC = 2.3||Anti-S. aureus clinical strains, activity value is MIC = 4.69||Anti-B. cereus, activity value is MIC = 9.38||Anti-B. subtilis, activity value is MIC = 4.69||Anti-E. faecium, activity value is MIC = 2.34 ug/ml||Anti-N. asteroides, activity value is MIC = 2.34 ug/ml||Anti-E. faecalis, activity value is MIC = 75 ug/ml||Anti-S. epidermidis, activity value is MIC = 9.38 ug/ml||Anti-C. albicans, activity value is MIC = 9.38 ug/ml||Anti-aquatic pathogens V. brasiliensis, activity value is MIC = 18.7 ug/ml||Anti-A. veronii, activity value is MIC = 9.3 ug/ml||Anti-and E. tarda, activity value is MIC = 18.7 ug/ml||Anti-this peptide also showed good activity against aquatic bacteria Gram- V. alginolyticus, activity value is MIC = 4.58 uM||Anti-V. brasiliensis, activity value is MIC = 1.15 uM||Anti-V. cholerae, activity value is MIC = 0.57 uM||Anti-V. fluvialis, activity value is MIC = 1.15 uM||Anti-V. harveyi, activity value is MIC = 1.15 uM||Anti-V. parahaemolyticus, activity value is MIC = 0.57 uM||Anti-V. splendidus, activity value is MIC = 1.15 uM||Anti-V. vulnificus, activity value is MIC = 4.58 uM||Anti-A. hydrophila, activity value is MIC = 1.15 uM||Anti-A. sobria, activity value is MIC = 2.29 uM||Anti-A.veronii, activity value is MIC = 2.29 uM||Anti-and N. asteroides, activity value is MIC = 1.15 uM||Antibacterial||Antibiofilm||Antifungal||Anti-Gram+ & Gram-||candidacidal||Anti-inflammatory||Anti-Escherichia coli ATCC25922, activity value is MIC = 4.69 ug/ml||Anti-E. coli -1, activity value is MIC = 4.69 ug/ml||Anti-E. coli -2, activity value is MIC = 9.38 ug/ml||Anti-E. coli -3, activity value is MIC = 4.69 ug/ml||Anti-E. coli -4, activity value is MIC = 9.38 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 1.17 ug/ml||Anti-Klebsiella pneumoniae -1, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae -2, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae -3, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae -4, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae -5, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae -6, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae -7, activity value is MIC = 18.75 ug/ml||Anti-Klebsiella oxytoca, activity value is MIC = 18.75 ug/ml||Anti-Proteus vulgaris, activity value is MIC = 18.75 ug/ml||Anti-Proteus mirabilis, activity value is MIC = 18.75 ug/ml||Anti-Acinetobacter baumannii -1, activity value is MIC = 18.75 ug/ml||Anti-A. Baumannii -2, activity value is MIC = 18.75 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 18.75 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 9.38 ug/ml||Anti-P. Aeruginosa -1, activity value is MIC = 2.34 ug/ml||Anti-S. Aureus -1, activity value is MIC = 9.38 ug/ml||Anti-S. Aureus -2, activity value is MIC = 9.38 ug/ml||Anti-S. Aureus -3, activity value is MIC = 4.69 ug/ml||Anti-S. Aureus -4, activity value is MIC = 4.69 ug/ml||Anti-Bacillus cereus, activity value is MIC = 9.38 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 4.69 ug/ml||Anti-Enterococcus faecium, activity value is MIC = 2.34 ug/ml||Anti-Nocardia asteroides, activity value is MIC = 2.34 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 75 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 9.38 ug/ml||Anti-C. Albicans -1, activity value is MIC = 9.38 ug/ml||Anti-C. Albicans -2, activity value is MIC = 9.38 ug/ml||Anti-C. Albicans -3, activity value is MIC = 9.38 ug/ml||Anti-C. Albicans -4, activity value is MIC = 9.38 ug/ml||Anti-C. glabrata, activity value is MIC = 9.38 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 18.75 ug/ml||Anti-Vibrio brasiliensis, activity value is MIC = 18.75 ug/ml||Anti-Vibrio cholerae, activity value is MIC = 18.75 ug/ml||Anti-Aeromonas sobria, activity value is MIC = 9.38 ug/ml||Anti-Aeromonas veronii, activity value is MIC = 9.38 ug/ml||Anti-Edwardsiella tarda, activity value is MIC = 18.75 ug/ml||Antimicrobial||Anticancer Chelonia mydas|||lung, green sea turtle, Chelonia mydas|||Chelonia mydas|||lung, green sea turtle, Chelonia mydas|||Animalia|||lung, green sea turtle, Chelonia mydas N/A "lung, green sea turtle, Chelonia mydas||Cm-CATH 2 exhibits low hemolytic activity, inducing 2.05%, 7.91%, 10.53%, and 12.2% hemolysis of human red blood cells at concentrations of 10, 50, 100, and 150 μg/ml, respectively.|||Human erythrocytes (12.2% hemolysis at 150 ug/ml)|||The document clearly provides the specific hemolytic data of the green sea turtle antimicrobial peptide Cm-CATH2. The core information is as follows: Hemolytic values of Cm-CATH2 In the “3.8. Hemolysis and cytotoxicity of Cm-CATH2” section, it is explicitly stated that Cm-CATH2 exhibits low hemolytic activity against human red blood cells (hRBCs), with the specific data as follows: At a concentration of 10 µg/ml, the hemolysis rate is only 2.05%; At a concentration of 50 µg/ml, the hemolysis rate is 7.91%; At a concentration of 100 µg/ml, the hemolysis rate is 10.53%; At a concentration of 150 µg/ml, the hemolysis rate is 12.2%. Key experimental background and basis Experimental method: Fresh human red blood cells were washed three times with PBS and then incubated with different concentrations of Cm-CATH2 at 37°C for 30 minutes. After centrifugation at 1500 rpm for 5 minutes, the absorbance of the supernatant was measured at 540 nm (reflecting the amount of hemoglobin released). A 0.1% Triton X-100 treated group was used as the 100% hemolysis positive control, and a PBS-treated group was used as the negative control. Safety comparison: The hemolysis of Cm-CATH2 is far lower than that of many antimicrobial peptides with high hemolytic activity observed in clinical studies (such as certain fish or reptile antimicrobial peptides). Its cytotoxicity to normal mammalian cells (such as human umbilical vein endothelial cells HUVEC and mouse macrophages RAW 264.7) is also very low (IC₅₀ for HUVEC is 238.2 µg/ml, and for RAW 264.7 is 703.2 µg/ml), which is much higher than its MIC values against most pathogens (1.17–18.75 µg/ml), demonstrating a good therapeutic window. In summary, Cm-CATH2 maintains low hemolytic activity even at high concentrations, which is an important safety feature for its potential as an anti-infective drug and provides a key basis for subsequent clinical translation.|||Human erythrocytes (12.2% hemolysis at 150 ug/ml)|||Therefore, this study also measured the hemolytic activity of CM-CATH2. CM-CATH2 has relatively low hemolytic activity, with lysis rates of human red blood cells at 10, 50, 100, and 150 µg/ml being 2.05%, 7.91%, 10.53%, and 12.2%, respectively.|||Many cathelicidins exhibit relatively high hemolytic activities, which significantly limit their clinical applications. Therefore, in the present study the hemolytic activity of Cm-CATH2 was also determined. Cm-CATH2 displayed low hemolytic activity, inducing the lysis of 2.05%, 7.91%, 10.53% and 12.2% of human erythrocytes at 10, 50, 100 and 150 ug/ml, respectively." "Dev Comp Immunol . 2019 Sep:98:189-204. doi: 10.1016/j.dci.2019.05.005. Epub 2019 May 20.||Ouyang et al., 2022|||31121185|||Dev Comp Immunol. 2019 May 20;98:189-204. doi: 10.1016/j.dci.2019.05.005. PubMed|||31121185|||Dev Comp Immunol . 2019 Sep:98:189-204. doi: 10.1016/j.dci.2019.05.005. Epub 2019 May 20.||Ouyang et al., 2022|||Dev Comp Immunol. 2019 Sep;98:189-204.|||Biomolecules. 2019 Jun 21;9(6):242|||Dev Comp Immunol. 2019 May 20;98:189-204. doi: 10.1016/j.dci.2019.05.005. PubMed" 33 FPDB03589 AP03080|||Cm-CATH3|||Cm-CATH3|||AP03080|||AP03080 TRGRWKRFWRGAGRFFRRHKEKIIRAAVDIVLS Anti-E. coli ATCC25922 and clinical strains, activity value is MIC = 1.17||Anti-S. dysenteriae, activity value is MIC = 1.17 ug/ml||Anti-K. Pneumoniae, activity value is MIC = 18.75||Anti-P. aeruginosa, activity value is MIC = 2.34||Anti-S. aureus, activity value is MIC = 1.17||Anti-P. aeruginosa, activity value is MIC = 4.69 ug/ml||Anti-B. cereus, activity value is MIC = 9.38 ug/ml||Anti-B. subtilis, activity value is MIC = 1.17 ug/ml||Anti-E. faecium, activity value is MIC = 1.17 ug/ml||Anti-N. asteroides, activity value is MIC = 2.34 ug/ml||Anti-E. faecalis, activity value is MIC = 37.5 ug/ml||Anti-S. epidermidis, activity value is MIC = 37.5 ug/ml||Anti-C. albicans, activity value is MIC = 2.34||Anti-C. glabrata, activity value is MIC = 18.75 ug/ml||Anti-C. neoformans, activity value is MIC = 75 ug/ml||Anti-aquatic pathogens V. brasiliensis, activity value is MIC = 75 ug/ml||Anti-V. cholerae, activity value is MIC = 75 ug/ml||Anti-A. veronii, activity value is MIC = 75 ug/ml||Anti-and E. tarda, activity value is MIC = 9.38 ug/ml||Antibacterial||Antifungal||Anti-Escherichia coli ATCC25922, activity value is MIC = 2.34 ug/ml||Anti-E. coli -1, activity value is MIC = 1.17 ug/ml||Anti-E. coli -2, activity value is MIC = 9.38 ug/ml||Anti-E. coli -3, activity value is MIC = 4.69 ug/ml||Anti-E. coli -4, activity value is MIC = 9.38 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 1.17 ug/ml||Anti-Klebsiella pneumoniae -1, activity value is MIC = 18.75 ug/ml||Anti-K. pneumoniae -2, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae -3, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae -4, activity value is MIC = 18.75 ug/ml||Anti-K. pneumoniae -5, activity value is MIC = 18.75 ug/ml||Anti-K. pneumoniae -6, activity value is MIC = 18.75 ug/ml||Anti-K. pneumoniae -7, activity value is MIC = 18.75 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 37.5 ug/ml||Anti-P. Aeruginosa -1, activity value is MIC = 2.34 ug/ml||Anti-S. Aureus -1, activity value is MIC = 18.75 ug/ml||Anti-S. Aureus -2, activity value is MIC = 9.38 ug/ml||Anti-S. Aureus -3, activity value is MIC = 75 ug/ml||Anti-S. Aureus -4, activity value is MIC = 1.17 ug/ml||Anti-Bacillus cereus, activity value is MIC = 9.38 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 1.17 ug/ml||Anti-Enterococcus faecium, activity value is MIC = 1.17 ug/ml||Anti-Nocardia asteroides, activity value is MIC = 2.34 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 37.5 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 37.5 ug/ml||Anti-C. Albicans -1, activity value is MIC = 2.34 ug/ml||Anti-C. Albicans -2, activity value is MIC = 9.38 ug/ml||Anti-C. Albicans -3, activity value is MIC = 9.38 ug/ml||Anti-C. Albicans -4, activity value is MIC = 9.38 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 75 ug/ml||Anti-Vibrio brasiliensis, activity value is MIC = 75 ug/ml||Anti-Vibrio cholerae, activity value is MIC = 75 ug/ml||Anti-Aeromonas veronii, activity value is MIC = 75 ug/ml||Anti-Edwardsiella tarda, activity value is MIC = 9.38 ug/ml||Anti-Gram+ & Gram-||candidacidal Chelonia mydas|||Chelonia mydas|||lung, green sea turtle, Chelonia mydas|||lung, green sea turtle, Chelonia mydas N/A lung, green sea turtle, Chelonia mydas||Cm-CATH 2 exhibits low hemolytic activity, inducing 2.05%, 7.91%, 10.53%, and 12.2% hemolysis of human red blood cells at concentrations of 10, 50, 100, and 150 μg/ml, respectively.|||Therefore, this study also measured the hemolytic activity of CM-CATH2. CM-CATH2 has relatively low hemolytic activity, with lysis rates of human red blood cells at 10, 50, 100, and 150 µg/ml being 2.05%, 7.91%, 10.53%, and 12.2%, respectively.|||Many cathelicidins exhibit relatively high hemolytic activities, which significantly limit their clinical applications. Therefore, in the present study the hemolytic activity of Cm-CATH2 was also determined. Cm-CATH2 displayed low hemolytic activity, inducing the lysis of 2.05%, 7.91%, 10.53% and 12.2% of human erythrocytes at 10, 50, 100 and 150 ug/ml, respectively. "Dev Comp Immunol . 2019 Sep:98:189-204. doi: 10.1016/j.dci.2019.05.005. Epub 2019 May 20.|||31121185|||31121185|||Dev Comp Immunol . 2019 Sep:98:189-204. doi: 10.1016/j.dci.2019.05.005. Epub 2019 May 20.|||Dev Comp Immunol. 2019 May 20;98:189-204. doi: 10.1016/j.dci.2019.05.005. PubMed" 33 FPDB03590 AP03081|||Cm-CATH4|||AP03081 MAFPFSTQRINPEIEEGNASLADLPVTHAGSLPGIKAQVRTALGIALLLVA Anti-E. coli strains, activity value is MIC = 9.38 ug/ml||Anti-S. dysenteriae, activity value is MIC = 9.38 ug/ml||Anti-K. Pneumoniae, activity value is MIC = 37.5 ug/ml||Anti-A. baumannii, activity value is MIC = 75 ug/ml||Anti-S. maltophilia, activity value is MIC = 18.75 ug/ml||Anti-S. aureus strains, activity value is MIC = 18.75 ug/ml||Anti-B. subtilis, activity value is MIC = 9.38 ug/ml||Anti-E. faecium, activity value is MIC = 4.69 ug/ml||Anti-N. asteroides, activity value is MIC = 37.5 ug/ml||Anti-C. albicans, activity value is MIC = 37.5 ug/ml||Anti-aquatic pathogens V. brasiliensis, activity value is MIC = 75 ug/ml||Anti-and E. tarda, activity value is MIC = 37.5 ug/ml||Anti-E. coli -1, activity value is MIC = 18.754 ug/ml||Anti-E. coli -2, activity value is MIC = 9.38 ug/ml||Anti-E. coli -3, activity value is MIC = 18.75 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae -4, activity value is MIC = 75 ug/ml||Anti-K. pneumoniae -5, activity value is MIC = 37.5 ug/ml||Anti-K. pneumoniae -6, activity value is MIC = 37.5 ug/ml||Anti-A. Baumannii -2, activity value is MIC = 75 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC = 75 ug/ml||Anti-S. Aureus -1, activity value is MIC = 18.75 ug/ml||Anti-S. Aureus -2, activity value is MIC = 75 ug/ml||Anti-S. Aureus -4, activity value is MIC = 18.75 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 9.38 ug/ml||Anti-Enterococcus faecium, activity value is MIC = 4.69 ug/ml||Anti-Nocardia asteroides, activity value is MIC = 37.5 ug/ml||Anti-C. Albicans -1, activity value is MIC = 37.5 ug/ml||Anti-C. Albicans -2, activity value is MIC = 37.5 ug/ml||Anti-Vibrio brasiliensis, activity value is MIC = 75 ug/ml||Anti-Edwardsiella tarda, activity value is MIC = 37.5 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Chelonia mydas|||lung, green sea turtle, Chelonia mydas|||lung, green sea turtle, Chelonia mydas N/A lung, green sea turtle, Chelonia mydas||Cm-CATH 2 exhibits low hemolytic activity, inducing 2.05%, 7.91%, 10.53%, and 12.2% hemolysis of human red blood cells at concentrations of 10, 50, 100, and 150 μg/ml, respectively.|||Therefore, this study also measured the hemolytic activity of CM-CATH2. CM-CATH2 has relatively low hemolytic activity, with lysis rates of human red blood cells at 10, 50, 100, and 150 µg/ml being 2.05%, 7.91%, 10.53%, and 12.2%, respectively.|||Many cathelicidins exhibit relatively high hemolytic activities, which significantly limit their clinical applications. Therefore, in the present study the hemolytic activity of Cm-CATH2 was also determined. Cm-CATH2 displayed low hemolytic activity, inducing the lysis of 2.05%, 7.91%, 10.53% and 12.2% of human erythrocytes at 10, 50, 100 and 150 ug/ml, respectively. "Dev Comp Immunol . 2019 Sep:98:189-204. doi: 10.1016/j.dci.2019.05.005. Epub 2019 May 20.|||31121185|||Dev Comp Immunol . 2019 Sep:98:189-204. doi: 10.1016/j.dci.2019.05.005. Epub 2019 May 20.|||Dev Comp Immunol. 2019 May 20;98:189-204. doi: 10.1016/j.dci.2019.05.005. PubMed" 51 FPDB03607 AP03104|||Hs02|||AP03104|||Hs02|||AP03104 KWAVRIIRKFIKGFIS Anti-E. coli ATCC 25922 and 4 strains, activity value is MIC = 1||Anti-P. aeruginosa ATCC 27853 and 8 strains, activity value is MIC = 1.67||Anti-S. aureus ATCC 25923 and 3 strains, activity value is MIC = 1||Anti-E. faecalis ATCC 29212, activity value is MIC = 2||Anti-it is showed to be active against S. epidermidis, activity value is MIC = 1 uM||Anti-T. rubrum, activity value is MIC = 8 uM||Anti-and C. albicans, activity value is MIC = 1.67 uM||Anti-C. albicans, activity value is MIC = 1.67 uM||Anti-S. aureus, activity value is MIC = 1 uM||Anti-S. epidermidis, activity value is MIC = 1 uM||Anti-P. aeruginosa, activity value is MIC = 1.67 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory||Antibiofilm||Antibacterial Homo sapiens|||other methods predicted, predicted from the human unconventional myosin 1H protein, intragenic antimicrobial peptide, Homo sapiens, primates, mammals, animals|||Homo sapiens [Human]|||other methods predicted, predicted from the human unconventional myosin 1H protein, intragenic antimicrobial peptide, Homo sapiens, primates, mammals, animals|||other methods predicted, predicted from the human unconventional myosin 1H protein, intragenic antimicrobial peptide, Homo sapiens, primates, mammals, animals Helix predicted from the human unconventional myosin 1H protein, intragenic antimicrobial peptide, Homo sapiens, primates, mammals, animals|||Human erythrocytes (50% hemolysis at >128 uM)|||Human erythrocytes (50% hemolysis at >128 uM) "Int J Mol Sci . 2019 Jul 23;20(14):3604. doi: 10.3390/ijms20143604.|||31386688|||Int J Mol Sci. 2019 Jul 23;20(14). pii: E3604. doi: 10.3390/ijms20143604. PubMed|||31386688|||Int J Mol Sci . 2019 Jul 23;20(14):3604. doi: 10.3390/ijms20143604.|||Int J Mol Sci. 2019 Jul 23;20(14). pii: E3604. doi: 10.3390/ijms20143604. PubMed" 16 FPDB03611 AP03108 ALSVASPSPSCNTHCPDPYLNLPGHYVCCDQHPGKCPPVPHCPAYPRKCFYDPECGLNEKCCNTPCGGKRCISIPYSGK Anti-V. parahaemolyticus, activity value is MIC < 25 uM||Anti-P-pastoris, activity value is MIC > 25 uM||Anti-and C. albicans, activity value is MIC < 25 uM||Anti-Gram+||Antifungal||candidacidal the mud crab, Scylla paramamosain|||the mud crab, Scylla paramamosain N/A the mud crab, Scylla paramamosain "Dev Comp Immunol . 2018 May:82:139-151. doi: 10.1016/j.dci.2018.01.006. Epub 2018 Jan 17.|||Dev Comp Immunol. 2018 May;82:139-151. doi: 10.1016/j.dci.2018.01.006.PubMed" 79 FPDB03612 AP03109 PSRSCNTHCPDPYLNLPGHYVCCDQHPGKCFRRDKCPPHELNKGLRQTIKYCHYDPECALHEKCCYDVCIEAKVCKLPE Anti-V. parahaemolyticus, activity value is MIC < 12.5 uM||Anti-V. alginolyticus, activity value is MIC < 12.5 uM||Anti-V. harveyi, activity value is MIC < 25 uM||Anti-A-hydrophila, activity value is MIC > 25 uM||Anti-P-pastoris, activity value is MIC > 25 uM||Anti-and C. albicans, activity value is MIC < 12.5 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal the mud crab, Scylla paramamosain|||the mud crab, Scylla paramamosain N/A the mud crab, Scylla paramamosain "Dev Comp Immunol . 2018 May:82:139-151. doi: 10.1016/j.dci.2018.01.006. Epub 2018 Jan 17.|||Dev Comp Immunol. 2018 May;82:139-151. doi: 10.1016/j.dci.2018.01.006.PubMed" 79 FPDB03616 AP03115 GFGCPLNQRACHRHCRSIGRRGGFCAGLIKQTCTCYRK Anti-Gram- bacteria E.coli, activity value is MIC > 250 uM||Anti-P.aeruginosa, activity value is MIC > 250 uM||Anti-S. aureus, activity value is MIC = 8 uM||Anti-L. grayi, activity value is MIC = 8 uM||Anti-S.epidermidis, activity value is MIC > 250 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal Ixodes holocyclus, Australia Bridge Ixodes holocyclus, Australia "Ticks Tick Borne Dis . 2019 Oct;10(6):101269. doi: 10.1016/j.ttbdis.2019.101269. Epub 2019 Aug 16.|||Ticks Tick Borne Dis. 2019 Aug 16:101269. doi: 10.1016/j.ttbdis.2019.101269. PubMed" 38 FPDB03617 AP03116 GFGCPNEWRCNAHCKRNRFRGGYCDSWFRRRCHCYG Anti-Gram- bacteria E.coli, activity value is MIC > 250 uM||Anti-P.aeruginosa, activity value is MIC > 250 uM||Anti-S. aureus, activity value is MIC = 8 uM||Anti-L. grayi, activity value is MIC = 8 uM||Anti-S.epidermidis, activity value is MIC > 250 uM||Anti-and fungi F. graminearum, activity value is MIC = 5 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal Ixodes holocyclus, Australia Bridge Ixodes holocyclus, Australia "Ticks Tick Borne Dis . 2019 Oct;10(6):101269. doi: 10.1016/j.ttbdis.2019.101269. Epub 2019 Aug 16.|||Ticks Tick Borne Dis. 2019 Aug 16:101269. doi: 10.1016/j.ttbdis.2019.101269. PubMed" 36 FPDB03622 AP03121|||Sm-Moronecidin|||Sm-Moronecidin|||AP03121|||AP03121 FFRHIVGAISRIFGQKQRDMAD Anti-Gram+ bacteria B. cereus, activity value is MIC = 12.5||Anti-B. subtilis, activity value is MIC = 6.25||Anti-C. glutamicum, activity value is MIC = 1.6||Anti-S. epidermidis, activity value is MIC = 12.5||Anti-P. aeruginosa, activity value is MIC = 25||Anti-P. fluorescens, activity value is MIC = 6.25||Anti-P. stutzeri, activity value is MIC = 3.1||Anti-A-hydrophila, activity value is MIC > 50 uM||Anti-E. coli, activity value is MIC = 12.5||Anti-S. flexneri, activity value is MIC = 6.2||Anti-V-alginolyticus, activity value is MIC > 50 uM||Anti-C. albicans, activity value is MIC = 12.5||Anti-and C. neoformans, activity value is MIC = 1.56||Antibacterial||Antifungal||Anti-Bacillus cereus, activity value is MIC = 12.5||Anti-Bacillus cereus, activity value is MBC = 25||Anti-Bacillus subtilis, activity value is MIC = 6.25||Anti-Staphylococcus aureus, activity value is MIC = 3.125||Anti-Staphylococcus aureus, activity value is MBC = 12.5||Anti-Corynebacterium glutamicum, activity value is MIC = 1.56||Anti-Staphylococcus epidermidis, activity value is MIC = 12.5||Anti-Staphylococcus epidermidis, activity value is MBC > 50 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 25||Anti-Pseudomonas fluorescens, activity value is MIC = 6.25||Anti-Pseudomonas fluorescens, activity value is MBC = 25||Anti-Pseudomonas stutzeri, activity value is MIC = 3.125||Anti-Aeromonas hydrophila, activity value is MIC > 50 uM||Anti-Escherichia coli, activity value is MIC = 12.5||Anti-Escherichia coli, activity value is MBC > 50 uM||Anti-Shigella flexneri, activity value is MIC = 6.25||Anti-Shigella flexneri, activity value is MBC > 50 uM||Anti-Vibrio parahaemolyticus, activity value is MIC > 50 uM||Anti-Vibrio alginolyticus, activity value is MIC > 50 uM||Anti-Candida albicans, activity value is MIC = 12.5||Anti-Cryptococcus neoformans, activity value is MIC = 1.56||Anti-Gram+ & Gram-||candidacidal Sebastiscus marmoratus|||Gill, rockfish, Sebastiscus marmoratus|||Gill, rockfish, Sebastiscus marmoratus N/A Gill, rockfish, Sebastiscus marmoratus|||Bacillus cereus[MIC = 12.5-25 uM], Bacillus cereus[MBC = 25-50 uM], Bacillus subtilis[MIC = 6.25-12.5 uM], Bacillus subtilis[MBC = <12.5 uM], Staphylococcus aureus[MIC = 3.125-6.25 uM], Staphylococcus aureus[MBC = 12.5-25 uM], Corynebacterium glutamicum[MIC = 1.56-3.125 uM], Corynebacterium glutamicum[MBC = <3.125 uM], Staphylococcus epidermidis[MIC = 12.5-25 uM], Staphylococcus epidermidis[MBC >50 uM], Pseudomonas aeruginosa[MIC = 25-50 uM], Pseudomonas aeruginosa[MBC = <50 uM], Pseudomonas fluorescens[MIC = 6.25-12.5 uM], Pseudomonas fluorescens[MBC = 25-50 uM], Pseudomonas stutzeri[MIC = 3.125-6.25 uM], Pseudomonas stutzeri[MBC = <6.25 uM], Aeromonas hydrophila[MIC >50 uM], Escherichia coli[MIC = 12.5-25 uM], Escherichia coli[MBC >50 uM], Shigella flexneri[MIC = 6.25-12.5 uM], Shigella flexneri[MBC >50 uM], Vibrio parahaemolyticus[MIC >50 uM], Vibrio alginolyticus[MIC >50 uM], Candida albicans[MIC = 12.5-25 uM], Candida albicans[MBC = <25 uM], Cryptococcus neoformans[MIC = 1.56-3.125 uM], Cryptococcus neoformans[MBC = <3.125 uM]|||Mouse hepatocytes AML12 (- at NA "Fish Shellfish Immunol . 2019 Oct:93:1007-1017. doi: 10.1016/j.fsi.2019.08.054. Epub 2019 Aug 23.|||31449978|||31449978|||Fish Shellfish Immunol . 2019 Oct:93:1007-1017. doi: 10.1016/j.fsi.2019.08.054. Epub 2019 Aug 23.|||Fish Shellfish Immunol. 2019 Aug 23. 93:1007-17. doi: 10.1016/j.fsi.2019.08.054.PubMed" 22 FPDB03628 AP03128|||Serrulin|||Serrulin|||AP03128|||AP03128 GFGGGRGGFGGGRGGFGGGGIGGGGFGGGYGGGKIKG Anti-Gram+ bacteria M. luteus A270, activity value is MIC = 0.5||Anti-E. coli SBS 363, activity value is MIC = 9||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 0.01||Anti-and yeast C. albicans MDMS, activity value is MIC = 1.5||Antibacterial||Antifungal||Anti-Micrococcus luteus A270, activity value is MIC = 1.87||Anti-Escherichia coli SBS 363, activity value is MIC = 30||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 0.05||Anti-Aspergillus niger, activity value is MIC = 12||Anti-Candida albicans MDM8, activity value is MIC = 6||Anti-Gram+ & Gram-||candidacidal Tityus serrulatus [Scorpion]|||Tityus serrulatus [Scorpion]|||Tityus serrulatus, Brazil, South America|||Tityus serrulatus, Brazil, South America Rich Tityus serrulatus, Brazil, South America|||Human erythrocytes (No hemolysis up to 50 uM)|||Human erythrocytes (No hemolysis up to 50 uM)|||—— "Toxins (Basel) . 2019 Sep 6;11(9):517. doi: 10.3390/toxins11090517.|||31489876|||31489876|||Toxins (Basel) . 2019 Sep 6;11(9):517. doi: 10.3390/toxins11090517.|||Toxins (Basel). 2019 Sep 6; 11(9):517. doi: 10.3390/toxins11090517. PubMed" 37 FPDB03629 AP03129|||Pinipesin|||Pinipesin|||AP03129|||AP03129 VAEARQGSFSY Anti-S. Typhimurinum ATCC 14028, activity value is MIC = 15.1 ug/ml||Anti-S. Arizonae ATCC 13314, activity value is MIC = 30.33 ug/ml||Anti-S. aureus ATCC 29213, activity value is MIC = 7.6 ug/ml||Anti-B. megaterium ATCC 10778, activity value is MIC = 15.2 ug/ml||Anti-B. subtilis ATCC 6633, activity value is MIC = 30.33 ug/ml||Anti-and B. bassiana, activity value is MIC = 30.3 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 15.16 ug/ml||Anti-Alcaligenes faecalis ATCC 8750, activity value is MIC = 15.16 ug/ml||Anti-Escherichia coli D31, activity value is MIC = 15.16 ug/ml||Anti-Escherichia coli SBS 363, activity value is MIC = 30.33 ug/ml||Anti-Serratia marcescens ATCC 4112, activity value is MIC = 30.33 ug/ml||Anti-Enterobacter cloacae -12, activity value is MIC = 30.33 ug/ml||Anti-Salmonella Typhimurinum ATCC 14028, activity value is MIC = 15.16 ug/ml||Anti-Salmonella Arizonae ATCC 13314, activity value is MIC = 30.33 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 30.33 ug/ml||Anti-Bacillus megaterium ATCC 10778, activity value is MIC = 15.16 ug/ml||Anti-Micrococcus luteus A270, activity value is MIC = 7.58 ug/ml||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 7.58 ug/ml||Anti-Candida albicans MDM8, activity value is MIC = 30.33 ug/ml||Anti-Candida tropicalis IOC 4560, activity value is MIC = 30.33 ug/ml||Anti-Saccharomyces cerevisiae PM340, activity value is MIC = 30.33 ug/ml||Anti-Aspergillus niger, activity value is MIC = 30.33 ug/ml||Anti-Beauveria bassiana, activity value is MIC = 30.33 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal Synthetic construct|||Scolopendra subspinipes subspinipes|||the exuviae extract , centipede, Scolopendra subspinipes subspinipes, Brazil, South America|||the exuviae extract , centipede, Scolopendra subspinipes subspinipes, Brazil, South America N/A the exuviae extract , centipede, Scolopendra subspinipes subspinipes, Brazil, South America|||Human erythrocytes [ 29.12% hemolysis at 1000000 uM ] "Sci Rep . 2019 Sep 20;9(1):13631. doi: 10.1038/s41598-019-50061-y.|||31541146|||https://pubmed.ncbi.nlm.nih.gov/31541146|||Sci Rep . 2019 Sep 20;9(1):13631. doi: 10.1038/s41598-019-50061-y.|||Sci Rep. 2019 Sep 20;9(1):13631. doi: 10.1038/s41598-019-50061-y. PubMed" 11 FPDB03653 AP03161|||Ixosin|||DRAMP02430|||Ixosin|||AP03161|||AP03161 GLHKVMREVLGYERNSYKKFFLR Anti-E. coli, activity value is MIC = 30 ug/ml||Anti-S. aureus, activity value is MIC = 3.7 ug/ml||Anti-and C. albicans, activity value is MIC = 7.5 ug/ml||Antibacterial||Antifungal||Anti-postive bacteria: Staphylococcus aureus, activity value is MIC = 3.7 ug/ml||Anti-Escherichia coli, activity value is MIC = 30 ug/ml||Anti-Candida albicans, activity value is MIC = 7.5 ug/ml||Anti-C. albicans, activity value is MIC = 7.5 ug/ml||Anti-Gram+ & Gram-||candidacidal Ixodes sinensis [Hard tick]|||Ixodes sinensis (Hard tick)|||salivary gland, Ixodes Sinensis|||salivary gland, Ixodes Sinensis N/A salivary gland, Ixodes Sinensis|||S. aureus ( MIC = 3.7 ug/ml ), E. coli ( MIC = 30 ug/ml ), C. albicans ( MIC = 7.5 ug/ml )|||Some antimicrobial peptides exhibit hemolytic activities [3]. Rabbit red blood cells were used to check for hemolytic capa bility in our experiments. Ixosinhadlittle hemolytic activity on red blood cells even with peptide concentrations up to 50 ug/ml. "Peptides . 2006 Jan;27(1):31-5. doi: 10.1016/j.peptides.2005.06.020. Epub 2005 Aug 8.|||16087274|||Peptides. 2006 Jan;27(1):31-5.||Ref.16087274|||16087274|||Peptides . 2006 Jan;27(1):31-5. doi: 10.1016/j.peptides.2005.06.020. Epub 2005 Aug 8.|||Peptides. 2006;27(1):31–35. PubMed" 23 FPDB03678 AP03202|||Brevinin-2GU|||AP03202|||DRAMP01916 GVIIDTLKGAAKTVAAELLRKAHCKLTNSC Anti-S. aureus, activity value is MIC = 64 uM||Anti-E. coli, activity value is MIC = 32 uM||Anti-and C. albicans, activity value is MIC = 64 uM||Anti-Propionibacterium acnes ATCC 11828, activity value is MIC = 12.5 uM||Anti-P. acnes strain 32548, activity value is MIC = 25 uM||Anti-P. acnes strain 33257, activity value is MIC = 6 uM||Anti-P. acnes strain 50247, activity value is MIC = 6 uM||Anti-P. acnes strain 18380, activity value is MIC = 12.5 uM||Anti-P. acnes strain 15725, activity value is MIC = 25 uM||Anti-P. acnes strain 29903, activity value is MIC = 25 uM||Anti-P. acnes strain 31766, activity value is MIC = 6 uM||Antimicrobial||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-diabetes Hylarana guentheri|||Hylarana guntheri|||Hylarana guntheri (Asian frog) N/A Hylarana guntheri|||The LC50 value for hemolysis of erythrocytes from a healthy donor was 700 uM. There was insufficient material to determine the MICs and LC50 values of the insulin-releasing peptides of the brevinin-1 and temporin families but the potent hemolytic activities of brevinin 1GUa and-GUb were confirmed by in cubations with the purified peptides. "Regul Pept . 2008 Nov 29;151(1-3):153-9. doi: 10.1016/j.regpep.2008.04.002. Epub 2008 Apr 13.|||22374306|||Regul Pept . 2008 Nov 29;151(1-3):153-9. doi: 10.1016/j.regpep.2008.04.002. Epub 2008 Apr 13.|||J Biosci Bioeng. 2009 Apr;107(4):460-463.|||Regul Pept. 2008 Nov 29;151(1-3):153-9. doi: 10.1016/j.regpep.2008.04.002.PubMed" 30 FPDB03679 AP03211|||Dermaseptin DRP-SP2|||Dermaseptin DRP-SP2|||AP03211|||AP03211 ASWKVFLKNIGKAAGKAVLNSVTDMVNQ Anti-E. coli ATCC 25922, activity value is MIC = 2.68 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2.68 uM||Anti-K. pneumoniae, activity value is MIC = 10.7 uM||Anti-E. coli ATCC 25922, activity value is MIC = 8 ug/ml||Anti-S. aureus ATCC 25923, activity value is MIC = 8 ug/ml||Anti-C. albicans, activity value is MIC = 32 ug/ml||Anti-S. aureus Oxacillin Resistant, activity value is MIC = 8 ug/ml||Anti-K. pneumoniae Clinical Isolate, activity value is MIC = 32 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Antimalarial Agalychnis spurrelli [Tree Frog]|||Agalychnis spurrelli [Tree Frog]|||The gliding tree frog, Agalychnis spurrelli, Central America|||The gliding tree frog, Agalychnis spurrelli, Central America N/A The gliding tree frog, Agalychnis spurrelli, Central America "Biomolecules . 2019 Oct 30;9(11):667. doi: 10.3390/biom9110667.|||31422479, 31671555|||31422479, 31671555|||Biomolecules . 2019 Oct 30;9(11):667. doi: 10.3390/biom9110667.|||Biomolecules. 2019 Oct 30;9(11):667. doi: 10.3390/biom9110667. PubMed" 28 FPDB03708 AP03261|||CAMPSQ13381|||U-VVTX-Vm1b|||AP03261|||AP03261 INLRAIAALAKKLL Anti-S. aureus, activity value is MIC = 16 ug/ml||Anti-and E. coli, activity value is MIC = 16 ug/ml||Anti-and C. albicans, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 16 ug/ml||Anti-Bacillus subtilis 168, activity value is MIC = 128 ug/ml||Anti-Enterococcus faecalis ATCC29212, activity value is MIC = 256 ug/ml||Anti-Escherichia coli ATCC25922, activity value is MIC = 16 ug/ml||Anti-Candida albicans CA10231, activity value is MIC = 64 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal V. ducalis [Social hornet wasp]|||V. ducalis [Social hornet wasp]|||venom glands, Vespa ducalis|||venom glands, Vespa ducalis , Asia N/A venom glands, Vespa ducalis||The hemolysis rate of AMP (U-VVTX-Vm 1a to -Vm 1e) is all less than 5%, ranging from 2.29% to 3.97%.|||Sheep RBCs, <5% hemolysis|||The hemolysis rate of AMP (U-VVTX-Vm 1a to -Vm 1e) is all less than 5%, ranging from 2.29% to 3.97%.|||All the tested AMPs showed almost no hemolysis of red blood cells. The hemolysis rates of AMPs (U-VVTX-Vm1a to -Vm1e) were all less than 5% and ranged from 2.29 to 3.97% (Table 2). "Toxicon . 2021 Sep:200:48-54. doi: 10.1016/j.toxicon.2021.07.001. Epub 2021 Jul 5.|||34237341|||34237341|||Toxicon . 2021 Sep:200:48-54. doi: 10.1016/j.toxicon.2021.07.001. Epub 2021 Jul 5.|||Toxicon. 2021 Jul 5:200:48-54. doi: 10.1016/j.toxicon.2021.07.001. PubMed" 14 FPDB03710 AP03263 GFLDVLKGVGKAALGAVTHLINQ Anti-E. coli, activity value is MIC = 27.5 uM||Anti-S. aureus, activity value is MIC = 27.5 uM||Anti-and C. albicans, activity value is MIC = 55 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Antimalarial the splendid leaf frog, Cruziohyla calcarifer, Central and South America|||the splendid leaf frog, Cruziohyla calcarifer, Central and South America N/A the splendid leaf frog, Cruziohyla calcarifer, Central and South America||It was found that Temporin-SHe has greater hemolytic activity than Temporin-SHd, because 84% hemolysis was achieved at a concentration of 25 μM (22% hemolysis at 12.5 μM), whereas Temporin-SHd required 100 μM to reach approximately the same percentage (91%) (25% and 72% hemolysis at 25 μM and 50 μM, respectively).|||It was found that Temporin-SHe has greater hemolytic activity than Temporin-SHd, because 84% hemolysis was achieved at a concentration of 25 μM (22% hemolysis at 12.5 μM), whereas Temporin-SHd required 100 μM to reach approximately the same percentage (91%) (25% and 72% hemolysis at 25 μM and 50 μM, respectively). "Amino Acids . 2021 Jun;53(6):853-868. doi: 10.1007/s00726-021-02986-w. Epub 2021 May 3.|||Amino Acids. 2021 Jun;53(6):853-868. doi: 10.1007/s00726-021-02986-w. PubMed" 23 FPDB03715 AP03270|||Cath-MH|||AP03270 APCKLGCKIKKVKQKIKQKLKAKVNAVKTVIGKISEHLG Anti-Gram- E. coli, activity value is MIC = 6.25 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 25 uM||Anti-S.aureus ATCC 25923, activity value is MIC > 100 uM||Anti-B. subtilis CMCC 63501, activity value is MIC = 6.25 uM||Anti-P. acnes ATCC 6919, activity value is MIC = 1.56 uM||Anti-and fungal C. albicans ATCC 10231, activity value is MIC = 12.5 uM||Antibacterial||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory||Enzyme inhibitor Microhyla heymonsivogt [dark-sided chorus frog]|||frog skin, Microhyla heymonsi vogt, China, Asia|||frog skin, Microhyla heymonsi vogt, China, Asia Helix frog skin, Microhyla heymonsi vogt, China, Asia||The hemolytic effect of cath-MH on mouse red blood cells was not applicable, with a hemolysis rate of 2.64 ± 1.40%.|||The hemolytic effect of cath-MH on mouse red blood cells was not applicable, with a hemolysis rate of 2.64 ± 1.40%.|||The results showed that cath-MH had no hemolysis effect in red blood cells from mice and its hemo lysis rate was 2.64 ± 1.40% at a concentration of 212.77 ug/ml. "Elife . 2021 Apr 20:10:e64411. doi: 10.7554/eLife.64411.|||34955858|||Elife . 2021 Apr 20:10:e64411. doi: 10.7554/eLife.64411.|||Elife. 2021 Apr 20;10:e64411. doi: 10.7554/eLife.64411. PubMed" 39 FPDB03738 AP03303 IFGKIWEGIKSLF Anti-Gram+ S. aureus ATCC 25293, activity value is MIC = 0.7 uM||Anti-S. aureus ATCC 6538, activity value is MIC = 3.3 uM||Anti-S. saprophyticus clincal strain, activity value is MIC = 0.7 uM||Anti-B. thuringensis, activity value is MIC = 16.6 uM||Anti-P.aeroginosa ATCC 15442, activity value is MIC > 150 uM||Anti-P. aeroginosa ATCC 27853, activity value is MIC = 66.5 uM||Anti-E. coli CCT 1371, activity value is MIC = 3.3 uM||Anti-E. coli ATCC 25922, activity value is MIC = 6.6 uM||Anti-P. mirabilis, activity value is MIC > 150 uM||Anti-and C. albicans, activity value is MIC = 12.5 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal venom, Opisthacanthus madagascariensis|||venom, Opisthacanthus madagascariensis, Africa Helix venom, Opisthacanthus madagascariensis "Biochem Biophys Res Commun . 2001 Aug 31;286(4):820-5. doi: 10.1006/bbrc.2001.5472.|||Biochem Biophys Res Commun. 2001 Aug 31;286(4):820-5. doi: 10.1006/bbrc.2001.5472. PubMed" 13 FPDB03745 AP03324|||DRAMP35823 GVITDTLKGVAKTVAAELLRKAHCKLTNSC Anti-Gram- E. coli ATCC 25922, activity value is MIC = 47.78 uM||Anti-P.aeruginosa ATCC 27853, activity value is MIC > 100 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 47.78 uM||Anti-P. acnes ATCC 6919, activity value is MIC = 14.93 uM||Anti-B. subtilis CMCC 63501, activity value is MIC = 4.97 uM||Anti-and fungi C. albicans ATCC 10231, activity value is MIC = 59.73 uM||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory skin, Microhyla pulchra, China, Asia|||Animalia|||skin, Microhyla pulchra, China, Asia Helix skin, Microhyla pulchra, China, Asia||Brevinin-2 MP (uM) Hemolysis rate (%) 100 1.42 ± 0.16 50 0.78 ± 0.07 25 0.63 ± 0.16 12.5 0.39 ± 0.17 6.25 0.10 ± 0.20|||Brevinin-2 MP (uM) Hemolysis rate (%) 100 1.42 ± 0.16 50 0.78 ± 0.07 25 0.63 ± 0.16 12.5 0.39 ± 0.17 6.25 0.10 ± 0.20|||brevinin-2MP was a low hemolytic against mouse erythrocyte, and the hemolysis ratio was only 1.42 ± 0.16% even at the highest concentration of 100 uM. "Front Pharmacol . 2021 Dec 16:12:783108. doi: 10.3389/fphar.2021.783108. eCollection 2021.|||Front Pharmacol. 2021 Dec 16;12:783108.|||Front Pharmacol. 2021 Dec 16;12:783108. doi: 10.3389/fphar.2021.783108. PubMed" 30 FPDB03749 AP03338 NEPTHLLKAFSKAGFQ Anti-A. niger A296 (all, activity value is MIC = 50||Anti-S.agalactiae ATCC12386, activity value is MIC = 100||Anti-S. aureus ATCC 29213, activity value is MIC = 25||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 12.5||Anti-Gram+ & Gram-||Antifungal||candidacidal lactic acid bacteria, Lactobacillus acidophilus: human microbiota:gut, symbiont bacteria|||lactic acid bacteria, Lactobacillus acidophilus: human microbiota:gut, symbiont bacteria N/A lactic acid bacteria, Lactobacillus acidophilus: human microbiota:gut, symbiont bacteria|||No hemolysis was observed at the evaluated concentrations, indi cating that Doderlin does nothave the ability togeneratehemolysis in human red blood cells (Fig. 7). Warning: this is an unreviewed preprint bioRxiv 16 FPDB03754 AP03343 MQLTSIAIILFAAMGAIANPIAAESDDLLARDAQLSKYGGECSLEHNTCTYRKDGKNHVVSCPSAANLRCKTDRHHCEYDDHHKTVDCQTPV Anti-S. aureus and C. albicans . MIC assays: S. aureus, activity value is MIC = 32 ug/ml||Anti-Gram+||Antifungal||candidacidal||Anti-MRSA||Antibiofilm Aspergillus tubingensis A01, isolated from soil|||Aspergillus tubingensis A01, isolated from soil Bridge Aspergillus tubingensis A01, isolated from soil "J Proteomics . 2021 Feb 20:233:104075. doi: 10.1016/j.jprot.2020.104075. Epub 2020 Dec 9.|||J Proteomics. 2021 Feb 20;233:104075. doi: 10.1016/j.jprot.2020.104075. PubMed" 92 FPDB03774 AP03416|||DRAMP20881|||AP03416|||DRAMP20881 VTCDLLSAEAKGVKVNHAACAAHCLLKRKRGGYCNKRRICVCRN Anti-E-coli, activity value is MIC > 75 ug/ml||Anti-S. aureus, activity value is MIC = 13.2 ug/ml||Anti-B. subtilis, activity value is MIC = 6 uM||Anti-C. albicans, activity value is MIC = 4.6 ug/ml||Anti-P.aeruginosa, activity value is MIC > 200 ug/ml||Anti-and K.pneumoniae, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 13.2||Anti-Bacillus subtilis, activity value is MIC = 6||Anti-Candida albicans, activity value is MIC = 4.6||Anti-##Fungi: Candida albicans, activity value is MIC = 4.6||Anti-Gram+||Antifungal||candidacidal Red flour beetle (Tribolium castaneum)|||red flour beetle, Tribolium castaneum|||Red flour beetle (Tribolium castaneum)|||red flour beetle, Tribolium castaneum Bridge "red flour beetle, Tribolium castaneum|||Target peptides (DAN1, DAN2, HOLO1, LOUDEF1): No hemolytic activity even at concentrations up to 200 ug/ml, and no cytotoxicity to mammalian red blood cells. - Positive control (bee venom peptide Melittin): Hemolytic activity begins to appear at a concentration of 12.5 ug/ml.|||[Ref.29501691] 0% haemolysis at 10 ug/ml, 0% haemolysis at 25 ug/ml, 0% haemolysis at 50 ug/ml, 0% haemolysis at 100 ug/ml, 0% haemolysis at 200 ug/ml against sheep red blood cells|||our results demonstrated that the peptides derived from arthropods genomes exhibited potent antimicrobial activities and low hemolytic activity." Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017. PubMed|||Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017.||Ref.29501691|||Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017. PubMed|||Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017.||Ref.29501691|||Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017. PubMed 44 FPDB03775 AP03417|||DRAMP20882|||AP03417|||DRAMP20882 ATCDLLSASTPWGSLNHSACAAHCLTKRYKGGRCRNGICRCRR Anti-E.coli DH5alpha, activity value is MIC > 100 ug/ml||Anti-S. aureus ATCC 29213, activity value is MIC = 6.8 ug/ml||Anti-B. subtilis, activity value is MIC = 5.8 uM||Anti-C. albicans ATCC 90028, activity value is MIC = 7.8 ug/ml||Anti-P. aeruginosa ATCC 27850, activity value is MIC = 43.7 ug/ml||Anti-and K. pneumoniae ATCC 700603, activity value is MIC = 26.6 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 35||Anti-Bacillus subtilis, activity value is MIC = 7||Anti-Candida albicans, activity value is MIC = 19.1||Anti-##Fungi: Candida albicans, activity value is MIC = 19.1||Anti-Gram+ & Gram-||Antifungal||candidacidal Human body louse (Pediculhumanus humanus)|||human body louse, Pediculus humanus humanus|||Human body louse (Pediculhumanus humanus)|||human body louse, Pediculus humanus humanus Bridge "human body louse, Pediculus humanus humanus||No hemolytic activity was observed within the concentration range of 12.5 ug/ml to 200 ug/ml.|||Target peptides (DAN1, DAN2, HOLO1, LOUDEF1): No hemolytic activity even at concentrations up to 200 ug/ml, and no cytotoxicity to mammalian red blood cells. - Positive control (bee venom peptide Melittin): Hemolytic activity begins to appear at a concentration of 12.5 ug/ml.|||No hemolytic activity was observed within the concentration range of 12.5 ug/ml to 200 ug/ml.|||[Ref.29501691] 0% haemolysis at 10 ug/ml, 0% haemolysis at 25 ug/ml, 0% haemolysis at 50 ug/ml, 0% haemolysis at 100 ug/ml, 0% haemolysis at 200 ug/ml against sheep red blood cells|||our results demonstrated that the peptides derived from arthropods genomes exhibited potent antimicrobial activities and low hemolytic activity." Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017. PubMed|||Peptides. 2018 May;103:26-30.||Ref.29501691|||Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017. PubMed|||Peptides. 2018 May;103:26-30.||Ref.29501691|||Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017. PubMed 43 FPDB03779 AP03421 GFLDTLKNIGKTVGRIALNVLT Anti-Gram- E. coli ATCC 25922, activity value is MIC = 6.83 uM||Anti-S. aureus ATCC 29213, activity value is MIC = 27.32 uM||Anti-and fungus C. albicans ATCC 10231, activity value is MIC = 54.64 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Antimalarial skin secretion, Imbabura treefrog, Boana picturata, Ecuador, South America|||skin secretion, Imbabura treefrog, Boana picturata, Ecuador, South America N/A skin secretion, Imbabura treefrog, Boana picturata, Ecuador, South America||The minimum inhibitory concentration (MIC) against E. coli was 6.83 uM (16 ug/ml), and the hemolysis rate was only 1.7% at this concentration; when the concentration was increased to 27.32 uM (64 ug/ml, which is the MIC against Staphylococcus aureus), the hemolysis rate was approximately 4.5%, and at the maximum concentration (218.54 uM, 512 ug/ml), the hemolysis rate did not exceed 29%.|||skin secretion, Imbabura treefrog, Boana picturata, Ecuador, South America|||The minimum inhibitory concentration (MIC) against E. coli was 6.83 uM (16 ug/ml), and the hemolysis rate was only 1.7% at this concentration; when the concentration was increased to 27.32 uM (64 ug/ml, which is the MIC against Staphylococcus aureus), the hemolysis rate was approximately 4.5%, and at the maximum concentration (218.54 uM, 512 ug/ml), the hemolysis rate did not exceed 29%. J Proteomics. 2022 May 28:104633. doi: 10.1016/j.jprot.2022.104633. PubMed|||J Proteomics. 2022 May 28:104633. doi: 10.1016/j.jprot.2022.104633. PubMed 22 FPDB03781 AP03423 GFLDTLKNIGKTVGKVALDVAKNVLT Anti-Gram- E. coli ATCC 25922, activity value is MIC = 11.79 uM||Anti-S. aureus ATCC 29213, activity value is MIC = 23.58 uM||Anti-and fungus C. albicans ATCC 10231, activity value is MIC = 47.16 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal skin secretion, Imbabura treefrog, Boana picturata, Ecuador, South America|||skin secretion, Imbabura treefrog, Boana picturata, Ecuador, South America N/A skin secretion, Imbabura treefrog, Boana picturata, Ecuador, South America||It exhibited the lowest hemolytic activity: within the effective antibacterial concentration range (11.79–47.16 uM, corresponding to 32–128 ug/ml), the hemolysis rate remained consistently ≤ 0.1%; even when the concentration was increased to 188.68 uM (512 ug/ml), the hemolysis rate still did not exceed 4%, showing the optimal safety profile.|||skin secretion, Imbabura treefrog, Boana picturata, Ecuador, South America|||It exhibited the lowest hemolytic activity: within the effective antibacterial concentration range (11.79–47.16 uM, corresponding to 32–128 ug/ml), the hemolysis rate remained consistently ≤ 0.1%; even when the concentration was increased to 188.68 uM (512 ug/ml), the hemolysis rate still did not exceed 4%, showing the optimal safety profile. J Proteomics. 2022 May 28:104633. doi: 10.1016/j.jprot.2022.104633. PubMed|||J Proteomics. 2022 May 28:104633. doi: 10.1016/j.jprot.2022.104633. PubMed 26 FPDB03785 AP03432 LNPLIKAGIFILKHRRPIGRGIEITGRGIKKFFSK Anti-from AP3431: active against Gram- bacteria E. coli ATCC 25922, activity value is MIC = 0.5 uM||Anti-P-aeruginosa ATCC 27853, activity value is MIC > 10.1 uM||Anti-S. enterica serovar Typhimurium ATCC 14028, activity value is MIC = 5.3 uM||Anti-A. baumannii KCTC 23254, activity value is MIC = 1 uM||Anti-K. pneumoniae subsp. pneumoniae KCTC 1726, activity value is MIC = 3 uM||Anti-E. cloacae subsp. cloacae ATCC 13047, activity value is MIC = 8.8 uM||Anti-S. aureus ATCC 6538, activity value is MIC = 0.3 uM||Anti-B. cereus ATCC 10876, activity value is MIC = 0.8 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 1.3 uM||Anti-S. agalactiae ATCC 27956, activity value is MIC = 2 uM||Anti-S. dysgalactiae ATCC 27957, activity value is MIC = 3.5 uM||Anti-S. equi subsp. zooepidemicus ATCC 43079, activity value is MIC = 2.3 uM||Anti-Gram- bacteria E. coli ATCC 25922, activity value is MIC = 0.5 uM bats, Myotis lucifugus|||bats, Myotis lucifugus N/A bats, Myotis lucifugus|||hemolysis, not tested;Registered 7/2022 Antibiotics, 11(8), 989. Publisher|||Antibiotics, 11(8), 989. Publisher 35 FPDB03786 AP03433 ILGPALRIGGRIAGRIAGKLIGDAINRHRERNRQRRG Anti-Gram- bacteria E. coli ATCC 25922, activity value is MIC = 1.7 uM||Anti-P-aeruginosa ATCC 27853, activity value is MIC > 9.8 uM||Anti-S. enterica serovar Typhimurium ATCC 14028, activity value is MIC = 5.4 uM||Anti-A. baumannii KCTC 23254, activity value is MIC = 1 uM||Anti-K. pneumoniae subsp. pneumoniae KCTC 1726, activity value is MIC = 3.2 uM||Anti-E. cloacae subsp. cloacae ATCC 13047, activity value is MIC = 7.3 uM||Anti-S. aureus ATCC 6538, activity value is MIC = 0.7 uM||Anti-B. cereus ATCC 10876, activity value is MIC = 1.5 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 1.5 uM||Anti-S. agalactiae ATCC 27956, activity value is MIC = 2 uM||Anti-S. dysgalactiae ATCC 27957, activity value is MIC = 4.4 uM||Anti-S. equi subsp. zooepidemicus ATCC 43079, activity value is MIC = 4.2 uM bats, Phyllostomus discolor|||bats, Phyllostomus discolor N/A bats, Phyllostomus discolor|||hemolysis, not tested; Registered 7/2022 Antibiotics, 11(8), 989. Publisher|||Antibiotics, 11(8), 989. Publisher 37 FPDB03803 AP03455|||Oligoventin|||AP03455|||DRAMP03257 QPFSLERW Anti-active against Gram+ M. luteus A270, activity value is MIC = 47.2||Anti-S. epidermidis ATCC 1222829213, activity value is MIC = 94.5||Anti-S. marcescens ATCC 4112, activity value is MIC = 23.53||Anti-and weakly yeast C. albicans MDM8, activity value is MIC = 94.5||Antibacterial||Antifungal ; N.A||Antimicrobial Phoneutria nigriventer|||the eggs, the Brazilian armed spider Phoneutria nigriventer (Ctenidae, Araneomorphae)|||Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)|||the eggs, the Brazilian armed spider Phoneutria nigriventer (Ctenidae, Araneomorphae) N/A the eggs, the Brazilian armed spider Phoneutria nigriventer (Ctenidae, Araneomorphae)||Low concentration range (0.4–94.5 uM, covering the MIC range of most bacterial strains): The hemolysis rate was only 2%; high concentration (188.9 uM, the maximum tested concentration, approximately 8 times the MIC of some bacterial strains): The hemolysis rate was only 4.3%.|||the eggs, the Brazilian armed spider Phoneutria nigriventer (Ctenidae, Araneomorphae)||Moreover, oligoventin exhibits 4.3% hemolytic activity against human erythrocytes at 188.9 uM and 2% at 94.5 uM (Figure S3 in Supplementary Material).|||Low concentration range (0.4–94.5 uM, covering the MIC range of most bacterial strains): The hemolysis rate was only 2%; high concentration (188.9 uM, the maximum tested concentration, approximately 8 times the MIC of some bacterial strains): The hemolysis rate was only 4.3%.|||Moreover, oligoventin exhibits 4.3% hemolytic activity against human erythrocytes at 188.9 uM and 2% at 94.5 uM (Figure S3 in Supplementary Material).|||oligoventin exhibits 4.3% hemolytic activity against human erythrocytes at 188.9 uM and 2% at 94.5 uM (less hemo.lytic). "Front Immunol. 2017 Jan 9;7:664. doi: 10.3389/fimmu.2016.00664. PubMed|||Front Immunol . 2017 Jan 9:7:664. doi: 10.3389/fimmu.2016.00664. eCollection 2016.|||https://pubmed.ncbi.nlm.nih.gov/31141959|||Front Immunol. 2017 Jan 9;7:664. doi: 10.3389/fimmu.2016.00664. PubMed|||Front Immunol . 2017 Jan 9:7:664. doi: 10.3389/fimmu.2016.00664. eCollection 2016.|||Submitted (OCT-2012) to UniProtKB|||Front Immunol. 2017 Jan 9;7:664. doi: 10.3389/fimmu.2016.00664. PubMed" 8 FPDB03934 AP03614 SDSVVSDIICTTFCSVTWCQSNCC Anti-killed S. aureus MTCC 1430, activity value is MIC = 0.8 ug/ml||Anti-E. coli MTCC 1610, activity value is MIC = 1.2 ug/ml||Anti-and C. albicans MTCC 183, activity value is MIC = 30||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Hemolytic Brevibacillus sp. strain AF8 N/A "Brevibacillus sp. strain AF8||At 4 ug/ml, it causes approximately 20% hemolysis of red blood cells, and at 6 ug/ml, the hemolysis rate reaches 50%.|||highly hemolytic (HC50 6 ug/ml). HEK 293T (LC50 25-50 ug/ml) and vero cells (LC50 25 ug/ml).|||At 4 ug/ml, it causes approximately 20% hemolysis of red blood cells, and at 6 ug/ml, the hemolysis rate reaches 50%.|||highly hemolytic (HC50 6 ug/ml). HEK 293T (TC50 25-50 ug/ml) and vero cells (TC50 25 ug/ml).|||The document mentions hemolysis-related data of Brevicillin, as follows: - Hemolysis rates at different concentrations: - At 4 µg/ml, the hemolysis rate is approximately 20%; - At 6 µg/ml, the hemolysis rate is approximately 50%; - At 20 µg/ml and 40 µg/ml, the hemolysis rate approaches 100% (comparable to the positive control treated with 0.1% Triton X-100). Note: In hemolysis experiments, the hemolysis effect caused by treatment with 0.1% Triton X-100 is taken as the 100% hemolysis standard, while PBS treatment is used as the 0% hemolysis control.|||highly hemolytic (HC50 6 ug/ml)." J Appl Microbiol. 2023 Mar 13:lxad054. doi: 10.1093/jambio/lxad054. PubMed|||J Appl Microbiol. 2023 Mar 13:lxad054. doi: 10.1093/jambio/lxad054. PubMed|||J Appl Microbiol. 2023 Mar 13:lxad054. doi: 10.1093/jambio/lxad054. PubMed|||J Appl Microbiol. 2023 Mar 13:lxad054. doi: 10.1093/jambio/lxad054. PubMed 24 FPDB03940 AP03625 TLSAC Anti-E. coli ATCC 25922, activity value is MIC = 25 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 30 uM||Anti-E. faecium, activity value is MIC = 40 uM||Anti-K. pneumonia, activity value is MIC = 30 uM||Anti-A. baumannii ATCC BAA-1605, activity value is MIC = 25 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 30 uM||Anti-C. albicans, activity value is MIC = 50 uM||Anti-A. solani, activity value is MIC = 20 uM||Anti-and U. maydis, activity value is MIC = 30 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibiofilm Pseudomonas aeruginosa strain PAST18, isolated from soil|||Pseudomonas aeruginosa strain PAST18, isolated from soil N/A Pseudomonas aeruginosa strain PAST18, isolated from soil Biochem Biophys Res Commun. 2023 Apr 21;663:78-86. doi: 10.1016/j.bbrc.2023.04.069.PMID: 37119769. PubMed|||Biochem Biophys Res Commun. 2023 Apr 21;663:78-86. doi: 10.1016/j.bbrc.2023.04.069.PMID: 37119769. PubMed|||Biochem Biophys Res Commun. 2023 Apr 21;663:78-86. doi: 10.1016/j.bbrc.2023.04.069.PMID: 37119769. PubMed|||Biochem Biophys Res Commun. 2023 Apr 21;663:78-86. doi: 10.1016/j.bbrc.2023.04.069.PMID: 37119769. PubMed 5 FPDB03941 AP03628|||CRAMP-18|||AP03628 GEKLKKIGQKIKNFFQKL Anti-CRAMP18 is active against E. coli KCTC 1682, activity value is MIC = 50 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 12.5 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 12.5 uM||Anti-B. subtilis KCTC 1918, activity value is MIC = 50 uM||Anti-S. pyogenes KCTC 3096, activity value is MIC = 50 uM||Anti-S-aureus KCTC 1621, activity value is MIC > 50 uM||Anti-C. albicans, activity value is MIC = 50 uM||Anti-A. fumigatus, activity value is MIC = 100 uM||Antibacterial Sequence truncation, animal-derived, natural derivative|||Synthetic construct|||Mus musculus|||Sequence truncation, animal-derived, natural derivative Helix Sequence truncation, animal-derived, natural derivative||The hemolysis rate is ≤ 0.2% at a concentration of 100 uM.|||0% hemolysis at 100 uM (not hemo.lytic).|||The hemolysis rate is ≤ 0.2% at a concentration of 100 uM.|||0% hemolysis at 100 uM (not hemo.lytic).|||0% hemolysis at 100 uM (not hemo.lytic). Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med.|||Biochem Biophys Res Commun. 2000 Sep 7;275(3):904-9. doi: 10.1006/bbrc.2000.3269. Pub-Med. 18 FPDB03951 AP03648|||RLLR5|||AP03648|||CAMPSQ17110 RLLRRLLRRLLRRLLRRLLR Anti-Gram- E. coli, activity value is MIC = 4 ug/ml||Anti-P. putida, activity value is MIC = 2 ug/ml||Anti-S. enteritidis, activity value is MIC = 1 ug/ml||Anti-B. subtilis, activity value is MIC = 2 ug/ml||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-S. mutans, activity value is MIC = 2 ug/ml||Anti-C. neoformans, activity value is MIC = 1 ug/ml||Anti-S. cerevisiae, activity value is MIC = 1 ug/ml||Anti-and C. albicans, activity value is MIC = 1 ug/ml||MIC against Pseudomonas aeruginosa||Staphylococcus aureus||Anti-HSV1 activity was assessed by plaque reduction assay||Sporozoite toxicity assay using Plasmodium berghei sporozoites||Antibacterial||Antiparasitic||Antiviral||Anti-Bacillus subtilis ATCC 62037, activity value is MIC = 2 ug/ml||Anti-Bacillus subtilis ATCC 62037, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 64 ug/ml||Anti-Streptococcus mutans ATCC 25175, activity value is MIC = 2 ug/ml||Anti-Streptococcus mutans ATCC 25175, activity value is MIC = 32 ug/ml||Anti-Escherichia coli ATCC 27325, activity value is MIC = 4 ug/ml||Anti-Escherichia coli ATCC 27325, activity value is MIC = 32 ug/ml||Anti-Pseudomonas putida ATCC 17426, activity value is MIC = 2 ug/ml||Anti-Pseudomonas putida ATCC 17426, activity value is MIC = 64 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Enteritidis ATCC 13076, activity value is MIC = 1 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Enteritidis ATCC 13076, activity value is MIC = 32 ug/ml||Anti-Cryptococcus neoformans ATCC 34881, activity value is MIC = 1 ug/ml||Anti-Cryptococcus neoformans ATCC 34881, activity value is MIC = 32 ug/ml||Anti-Saccharomyces cerevisiae ATCC 44774, activity value is MIC = 1 ug/ml||Anti-Saccharomyces cerevisiae ATCC 44774, activity value is MIC = 32 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 1 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 32 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 1 ug/ml||Anti-Streptococcus mutans, activity value is MIC = 2 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 2 ug/ml||Anti-Escherichia coli, activity value is MIC = 2 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 1 ug/ml||Anti-Serratia marcescens, activity value is MIC = 2 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 2 ug/ml||Anti-Candida albicans, activity value is MIC = 8 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 8 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is IC50 = 28 uM||Anti-Staphylococcus aureus ATCC 6538P, activity value is IC50 = 16 uM de novo designed, man-made sequences|||Synthetic construct|||de novo designed, man-made sequences|||Synthetic construct Helix de novo designed, man-made sequences J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||17681018|||14718539, 10890923|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med. 20 FPDB03952 AP03649|||N-|||N-|||AP03649|||DRAMP31401|||CAMPSQ17109|||N-|||DRAMP31401|||AP03649 APKAMRLLRRLLRRLLR Anti-Gram- E. coli, activity value is MIC = 2 ug/ml||Anti-P. putida, activity value is MIC = 4 ug/ml||Anti-S. enteritidis, activity value is MIC = 2 ug/ml||Anti-B. subtilis, activity value is MIC = 2 ug/ml||Anti-S. aureus, activity value is MIC = 2 ug/ml||Anti-S. mutans, activity value is MIC = 4 ug/ml||Anti-C. neoformans, activity value is MIC = 2 ug/ml||Anti-S. cerevisiae, activity value is MIC = 2 ug/ml||Anti-and C. albicans, activity value is MIC = 1 ug/ml||MIC against Pseudomonas aeruginosa||Staphylococcus aureus||Anti-HSV1 activity was assessed by plaque reduction assay||Sporozoite toxicity assay using Plasmodium berghei sporozoites||Anti-Bacillus subtilis ATCC 62037, activity value is MIC = 2 ug/ml||Anti-Bacillus subtilis ATCC 62037, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 16 ug/ml||Anti-Streptococcus mutans ATCC 25175, activity value is MIC = 4 ug/ml||Anti-Streptococcus mutans ATCC 25175, activity value is MIC = 32 ug/ml||Anti-Escherichia coli ATCC 27325, activity value is MIC = 2 ug/ml||Anti-Escherichia coli ATCC 27325, activity value is MIC = 16 ug/ml||Anti-Pseudomonas putida ATCC 17426, activity value is MIC = 4 ug/ml||Anti-Pseudomonas putida ATCC 17426, activity value is MIC = 32 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Enteritidis ATCC 13076, activity value is MIC = 2 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Enteritidis ATCC 13076, activity value is MIC = 16 ug/ml||Anti-Cryptococcus neoformans ATCC 34881, activity value is MIC = 2 ug/ml||Anti-Cryptococcus neoformans ATCC 34881, activity value is MIC = 16 ug/ml||Anti-Saccharomyces cerevisiae ATCC 44774, activity value is MIC = 2 ug/ml||Anti-Saccharomyces cerevisiae ATCC 44774, activity value is MIC = 8 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 1 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 8 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is IC50 > 53 uM||Anti-Staphylococcus aureus ATCC 6538P, activity value is IC50 = 2 uM||Antimicrobial||Antiviral||Antibacterial||Antiparasitic de novo designed, man-made sequences|||Synthetic construct|||de novo designed, man-made sequences|||Synthetic construct Helix de novo designed, man-made sequences J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||14718539|||14718539|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||FEBS J. 2007 Sep;274(17):4511-25.|||17681018|||https://pubmed.ncbi.nlm.nih.gov/14718539|||FEBS J. 2007 Sep;274(17):4511-25.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med. 17 FPDB03953 AP03650 RLLRRLLRRLLRLQKKGI Anti-Gram- E. coli, activity value is MIC = 2 ug/ml||Anti-P. putida, activity value is MIC = 4 ug/ml||Anti-S. enteritidis, activity value is MIC = 4 ug/ml||Anti-B. subtilis, activity value is MIC = 4 ug/ml||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-S. mutans, activity value is MIC = 4 ug/ml||Anti-C. neoformans, activity value is MIC = 2 ug/ml||Anti-S. cerevisiae, activity value is MIC = 4 ug/ml||Anti-and C. albicans, activity value is MIC = 2 ug/ml de novo designed, man-made sequences Helix de novo designed, man-made sequences J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med. 18 FPDB03954 AP03651|||N-|||N-|||AP03651|||AP03651 APKAMRLLRRLLRLQKKGI Anti-Gram- E. coli, activity value is MIC = 1 ug/ml||Anti-P. putida, activity value is MIC = 1 ug/ml||Anti-S. enteritidis, activity value is MIC = 1 ug/ml||Anti-B. subtilis, activity value is MIC = 1 ug/ml||Anti-S. aureus, activity value is MIC = 2 ug/ml||Anti-S. mutans, activity value is MIC = 1 ug/ml||Anti-C. neoformans, activity value is MIC = 0.5 ug/ml||Anti-S. cerevisiae, activity value is MIC = 0.5 ug/ml||Anti-and C. albicans, activity value is MIC = 0.5 ug/ml||Antibacterial ; Synthetic construct||Anti-Bacillus subtilis ATCC 62037, activity value is MIC = 1 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 2 ug/ml||Anti-Streptococcus mutans ATCC 25175, activity value is MIC = 1 ug/ml||Anti-Escherichia coli ATCC 27325, activity value is MIC = 1 ug/ml||Anti-Pseudomonas putida ATCC 17426, activity value is MIC = 1 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Enteritidis ATCC 13076, activity value is MIC = 1 ug/ml||Anti-Cryptococcus neoformans ATCC 34881, activity value is MIC = 0.5 ug/ml||Anti-Saccharomyces cerevisiae ATCC 44774, activity value is MIC = 0.5 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 0.5 ug/ml de novo designed, man-made sequences|||Synthetic construct|||de novo designed, man-made sequences Helix de novo designed, man-made sequences|||Bacillus subtilis ATCC 62037[MIC = 1 ug/ml], Staphylococcus aureus ATCC 15752[MIC = 2 ug/ml], Streptococcus mutans ATCC 25175[MIC = 1 ug/ml], Escherichia coli ATCC 27325[MIC = 1 ug/ml], Pseudomonas putida ATCC 17426[MIC = 1 ug/ml], Salmonella enterica subsp. enterica serovar Enteritidis ATCC 13076[MIC = 1 ug/ml], Cryptococcus neoformans ATCC 34881[MIC = 0.5 ug/ml], Saccharomyces cerevisiae ATCC 44774[MIC = 0.5 ug/ml], Candida albicans ATCC 10231[MIC = 0.5 ug/ml] J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||https://pubmed.ncbi.nlm.nih.gov/14718539|||14718539|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med. 19 FPDB03955 AP03652|||TN-|||TN-|||AP03652|||AP03652 PKAMRLLRRLLRLQKKG Anti-Gram- E. coli, activity value is MIC = 4 ug/ml||Anti-P. putida, activity value is MIC = 2 ug/ml||Anti-S. enteritidis, activity value is MIC = 1 ug/ml||Anti-B. subtilis, activity value is MIC = 4 ug/ml||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-S. mutans, activity value is MIC = 2 ug/ml||Anti-C. neoformans, activity value is MIC = 2 ug/ml||Anti-S. cerevisiae, activity value is MIC = 1 ug/ml||Anti-and C. albicans, activity value is MIC = 1 ug/ml||Anti-Bacillus subtilis ATCC 62037, activity value is MIC = 4 ug/ml||Anti-Bacillus subtilis ATCC 62037, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 64 ug/ml||Anti-Streptococcus mutans ATCC 25175, activity value is MIC = 2 ug/ml||Anti-Streptococcus mutans ATCC 25175, activity value is MIC = 64 ug/ml||Anti-Escherichia coli ATCC 27325, activity value is MIC = 4 ug/ml||Anti-Escherichia coli ATCC 27325, activity value is MIC = 64 ug/ml||Anti-Pseudomonas putida ATCC 17426, activity value is MIC = 2 ug/ml||Anti-Pseudomonas putida ATCC 17426, activity value is MIC = 64 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Enteritidis ATCC 13076, activity value is MIC = 1 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Enteritidis ATCC 13076, activity value is MIC = 32 ug/ml||Anti-Cryptococcus neoformans ATCC 34881, activity value is MIC = 2 ug/ml||Anti-Cryptococcus neoformans ATCC 34881, activity value is MIC = 64 ug/ml||Anti-Saccharomyces cerevisiae ATCC 44774, activity value is MIC = 1 ug/ml||Anti-Saccharomyces cerevisiae ATCC 44774, activity value is MIC = 32 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 1 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 32 ug/ml hybrid peptide, designed, man-made sequences|||Synthetic construct|||hybrid peptide, designed, man-made sequences Helix hybrid peptide, designed, man-made sequences J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||14718539|||14718539|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med. 17 FPDB03956 AP03653|||N-Magainin-C|||N-Magainin-C|||AP03653|||AP03653 APKAMHSAKKFGKAFVGEIMLQKKGI Anti-Gram- E. coli, activity value is MIC = 64 ug/ml||Anti-P. putida, activity value is MIC = 64 ug/ml||Anti-S. enteritidis, activity value is MIC = 32 ug/ml||Anti-B. subtilis, activity value is MIC = 64 ug/ml||Anti-S. aureus, activity value is MIC = 64 ug/ml||Anti-S.mutans, activity value is MIC = 128 ug/ml||Anti-C. neoformans, activity value is MIC = 16 ug/ml||Anti-S. cerevisiae, activity value is MIC = 32 ug/ml||Anti-and C. albicans, activity value is MIC = 32 ug/ml||Anti-Bacillus subtilis ATCC 62037, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus ATCC 15752, activity value is MIC = 64 ug/ml||Anti-Streptococcus mutans ATCC 25175, activity value is MIC = 128 ug/ml||Anti-Escherichia coli ATCC 27325, activity value is MIC = 64 ug/ml||Anti-Pseudomonas putida ATCC 17426, activity value is MIC = 64 ug/ml||Anti-Salmonella enterica subsp. enterica serovar Enteritidis ATCC 13076, activity value is MIC = 32 ug/ml||Anti-Cryptococcus neoformans ATCC 34881, activity value is MIC = 16 ug/ml||Anti-Saccharomyces cerevisiae ATCC 44774, activity value is MIC = 32 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 32 ug/ml hybrid peptide, designed, man-made sequences|||Synthetic construct|||Synthetic construct|||hybrid peptide, designed, man-made sequences|||hybrid peptide, designed, man-made sequences Helix hybrid peptide, designed, man-made sequences J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||14718539|||14718539|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418201. Pub-Med.|||J Biol Chem. 2004 Apr 2;279(14):13896-901. doi: 10.1074/jbc.M311418200. Pub-Med. 26 FPDB03975 AP03681|||Peptide 4|||P9-4|||AP03681|||AP03681 KWRRWIRWL Anti-Gram- E. coli, activity value is MIC = 6.2 ug/ml||Anti-P. aeruginosa, activity value is MIC = 6.2 ug/ml||Anti-S. aeurus, activity value is MIC = 3.1 ug/ml||Anti-C. albicans, activity value is MIC = 3.1 ug/ml||Anti-and F. solani, activity value is MIC = 25 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2 uM||Anti-Escherichia coli ST131, activity value is MIC = 2 uM||Anti-Klebsiella pneumoniae ST258, activity value is MIC = 4 uM||Anti-Candida albicans, activity value is MIC > 100 uM amino acid substitution|||Synthetic construct|||amino acid substitution N/A HC50 400 ug/ml, not hemo.lytic. Provided by Arjun Nair.|||HC50 400 ug/ml, not hemo.lytic. Biochem Biophys Res Commun. 2010 Jul 30;398(3):594-600. doi: 10.1016/j.bbrc.2010.06.131. Pub-Med.|||30447380|||https://pubmed.ncbi.nlm.nih.gov/28105725|||Biochem Biophys Res Commun. 2010 Jul 30;398(3):594-600. doi: 10.1016/j.bbrc.2010.06.131. Pub-Med.|||Biochem Biophys Res Commun. 2010 Jul 30;398(3):594-600. doi: 10.1016/j.bbrc.2010.06.131. Pub-Med. 9 FPDB03976 AP03682|||Bp76|||Bp77|||Bp78|||BP76|||AP03682 KKLFKKILKFL Anti-Gram- E. coli, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa, activity value is MIC = 16 ug/ml||Anti-S. aeurus, activity value is MIC = 62.3 ug/ml||Anti-C. albicans, activity value is MIC = 25 ug/ml||Anti-and F. solani, activity value is MIC = 50 ug/ml||Anti-X. axonopodis pv. vesicatoria, activity value is MIC = 2.5||Anti-and E. amylovora, activity value is MIC = 2.5||Anti-Pseudomonas syringae, activity value is MIC = 2.5||Anti-Xanthomonas axonopodis, activity value is MIC = 2.5||Anti-Erwinia amylovora, activity value is MIC = 2.5||Anti-Pseudomonas syringae, activity value is MIC = 5.0||Anti-Erwinia amylovora, activity value is MIC = 5.0||Anti-F. oxysporum, activity value is MIC = 0.6||Anti-P. expansum, activity value is MIC = 25||Anti-A. niger, activity value is MIC = 20||Anti-R. stolonifer, activity value is MIC = 25||Anti-Candida albicans, activity value is MIC = 25 uM de novo designed, man-made sequences|||Synthetic construct|||Synthetic construct|||de novo designed, man-made sequences N/A HC50 400 ug/ml, little hemo.lytic (34% hemolysis at 150 uM).|||Human RBC 3±1% hemolysis at 50 uM|||Human RBC (6±0.6% hemolysis at 50 uM)|||Human RBC (40±4.0% hemolysis at 50 uM)|||HC50 400 ug/ml, little hemo.lytic (34% hemolysis at 150 uM). Biochem Biophys Res Commun. 2010 Jul 30;398(3):594-600. doi: 10.1016/j.bbrc.2010.06.131. Pub-Med.|||17980935|||https://pubmed.ncbi.nlm.nih.gov/19617390|||https://pubmed.ncbi.nlm.nih.gov/28105725|||Biochem Biophys Res Commun. 2010 Jul 30;398(3):594-600. doi: 10.1016/j.bbrc.2010.06.131. Pub-Med. 11 FPDB03977 AP03683|||Undefined|||Undefined|||AP03683 GKLFKKILKIL Anti-Gram- E. coli, activity value is MIC = 3.1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 12.5 ug/ml||Anti-S. aeurus, activity value is MIC = 12.5 ug/ml||Anti-C. albicans, activity value is MIC = 3.1 ug/ml||Anti-and F. solani, activity value is MIC = 12.5 ug/ml||Anti-Escherichia coli ATCC 8739, activity value is MIC = 3.1 ug/ml||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 12.5 ug/ml||Anti-Staphylococcus aureus ATCC 6538, activity value is MIC = 12.5 ug/ml||Anti-Candida albicans ATCC 10231, activity value is MIC = 3.1 ug/ml||Anti-Fusarium solani ATCC 36031, activity value is MIC = 12.5 ug/ml amino acid substitution, de novo designed, man-made sequences|||Synthetic construct|||Synthetic construct|||amino acid substitution, de novo designed, man-made sequences Helix HC50 400 ug/ml, not hemo.lytic. Provided by Arjun Nair. Biochem Biophys Res Commun. 2010 Jul 30;398(3):594-600. doi: 10.1016/j.bbrc.2010.06.131. Pub-Med.|||20603106|||https://pubmed.ncbi.nlm.nih.gov/20603106|||Biochem Biophys Res Commun. 2010 Jul 30;398(3):594-600. doi: 10.1016/j.bbrc.2010.06.131. Pub-Med. 11 FPDB03978 AP03684|||P1|||P3|||P11-6|||AP03684 KKLIKKILKIL Anti-Gram- E. coli, activity value is MIC = 3.1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 6.25 ug/ml||Anti-S. aeurus, activity value is MIC = 6.25 ug/ml||Anti-C. albicans, activity value is MIC = 3.1 ug/ml||Anti-and F. solani, activity value is MIC = 12.5 ug/ml||Anti-A. tumefaciens, activity value is MIC = 12||Anti-E. coli ATCC, activity value is MIC = 14.5||Anti-E. coli K12, activity value is MIC = 15.8||Anti-E. coli BL21, activity value is MIC = 17.7||Anti-E. coli BL21 Resistant to P1, activity value is MIC = 194||Anti-A. tumefaciens, activity value is MIC = 4.6||Anti-E. coli ATCC, activity value is MIC = 3.7||Anti-E. coli K12, activity value is MIC = 4.8||Anti-E. coli BL21, activity value is MIC = 4||Anti-E. coli BL21 Resistant to P1, activity value is MIC = 19.3||Anti-Candida albicans, activity value is MIC = 3.125 uM amino acid substitution, de novo designed, man-made sequences|||Synthetic construct|||Synthetic construct|||amino acid substitution, de novo designed, man-made sequences Helix HC50 400 ug/ml, not hemo.lytic. Provided by Arjun Nair. Biochem Biophys Res Commun. 2010 Jul 30;398(3):594-600. doi: 10.1016/j.bbrc.2010.06.131. Pub-Med.|||33813188|||https://pubmed.ncbi.nlm.nih.gov/28105725|||Biochem Biophys Res Commun. 2010 Jul 30;398(3):594-600. doi: 10.1016/j.bbrc.2010.06.131. Pub-Med. 11 FPDB03993 AP03714 KEPRLLCRQCVRMILNVEKL Anti-Gram+ B. cereus, activity value is MIC = 4||Anti-E. coli, activity value is MIC = 8 uM||Anti-MDR P. aeruginosa, activity value is MIC = 4||Anti-and fungi C. albicans, activity value is MIC = 32 uM Sequence alignment N/A N/A Front Microbiol. 2023 Jul 28;14:1249175. doi: 10.3389/fmicb.2023.1249175IF: 4.0 Q2 . .|||Front Microbiol. 2023 Jul 28;14:1249175. doi: 10.3389/fmicb.2023.1249175. Pub-Med.|||Front Microbiol. 2023 Jul 28;14:1249175. doi: 10.3389/fmicb.2023.1249175. Pub-Med. 20 FPDB03994 AP03715|||AP03713 FRYKVVDLAVNFGKKII Anti-Gram+ B. cereus, activity value is MIC = 4||Anti-E. coli, activity value is MIC = 4 uM||Anti-MDR P. aeruginosa, activity value is MIC = 4||Anti-and fungi C. albicans, activity value is MIC = 32 uM Sequence alignment,|||Sequence alignment N/A N/A Front Microbiol. 2023 Jul 28;14:1249175. doi: 10.3389/fmicb.2023.1249175IF: 4.0 Q2 .|||Front Microbiol. 2023 Jul 28;14:1249175. doi: 10.3389/fmicb.2023.1249175. Pub-Med.|||Front Microbiol. 2023 Jul 28;14:1249175. doi: 10.3389/fmicb.2023.1249175. Pub-Med. 17 FPDB03995 AP03720|||SP-E|||AP03720 DKPKKKPPPPAGPPPPPPPPPGPPPPGP Anti-A. baumannii, activity value is MIC = 1.053||Anti-E. coli ATCC 25922, activity value is MIC = 3.315||Anti-K. pneumoniae, activity value is MIC = 2.386||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 2.662 uM||Anti-C. neoformans 6995, activity value is EC50 = 2.215 uM||Anti-A. fumigatus UP1, activity value is EC50 = 58.68 uM||Anti-and C. albicans SC5314 or UP10, activity value is EC50 = 2.581||Anti-but not S. aureus, activity value is EC50 > 100 uM||Anti-E. coli ATCC 25922, activity value is EC50 = 3.3||Anti-P. aeruginosa ATCC 9027, activity value is EC50 = 2.7||Anti-A. baumannii I, activity value is EC50 = 1.981||Anti-K. pneumoniae I, activity value is EC50 = 3.3||Anti-Salmonella typhimurium ATCC 14028, activity value is EC50 = 1.447 porcine salivary gland granules, Sus scrofa domesticus|||Sus scrofa [Pig]|||porcine salivary gland granules, Sus scrofa domesticus|||porcine salivary gland granules, Sus scrofa domesticus Rich not hemolytic till 250 uM (0.026% vs. 2.6% 0.5% Triton-X100). SP-E did not show particular toxicity at 50 uM (MTT assay) to murine 3T3 fibroblast cell line, HL60 monocytes and the oral squamous carcinoma cell line PECA/PJ15.|||not hemo.lytic till 250 uM (0.026% vs. 2.6% 0.5% Triton-X100). Biochim Biophys Acta. 2013 Mar;1828(3):1066-74. doi: 10.1016/j.bbamem.2012.12.013IF: 2.8 Q2 .|||30046246|||Biochim Biophys Acta. 2013 Mar;1828(3):1066-74. doi: 10.1016/j.bbamem.2012.12.013. Pub-Med.|||Biochim Biophys Acta. 2013 Mar;1828(3):1066-74. doi: 10.1016/j.bbamem.2012.12.013. Pub-Med. 28 FPDB04022 AP03758|||MBMAP28|||AP03758 GGLRSLGRKILRAWKKYGPQATPATRQ Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-E. coli ATCC 25922, activity value is MIC = 1 uM||Anti-E. coli ML35, activity value is MIC = 0.5 uM||Anti-S. typhimurium ATCC 14028, activity value is MIC = 1 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 0.5 uM||Anti-S. marcescens ATCC 8100, activity value is MIC = 4 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 8 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 2 uM||Anti-B. megaterium Bm11, activity value is MIC = 2 uM||Anti-C. albicans, activity value is MIC = 8 uM||Anti-C. neoformans, activity value is MIC = 4 uM||Anti-E. coli ATCC 25922 ML-35, activity value is MIC = 0.5||Anti-and C. neoformans, activity value is MIC = 4 uM segment substitution|||Bos taurus [Bovine]|||segment substitution Helix Thehemolyticactivityof thetwoBMAPswasmuchlower, whenmeasuredonbovineerythrocytes(datanotshown).These cellswere5±10-foldlesssusceptiblethanhumanredbloodcells toBMAP-28(3,6,and22%hemolysisat10,30,and100000000 uM peptide),andvirtuallyunaffectedbyBMAP-27evenat102000000 uM.|||low hemo.lytic to human RBC at 100 uM (3.3%), HC50 >100 uM. J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461.|||8910461|||J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461.|||J Biol Chem. 1996 Nov 8;271(45):28375-81. doi: 10.1074/jbc.271.45.28375. 8910461. 27 FPDB04030 AP03769|||Hs01|||Hs01|||AP03769|||AP03769 LKMLGMLFHNIRNILKTV Anti-Gram+||Antifungal||candidacidal||Anti-C. albicans, activity value is MIC = 64 uM||Anti-S. aureus, activity value is MIC = 128 uM||Anti-S. epidermidis, activity value is MIC = 64 uM||Anti-weakly active against S.aureus ATCC 25923, activity value is MIC = 128 uM||Anti-and C. albicans, activity value is MIC = 64 uM predicted from the human unconventional myosin 1H protein, intragenic antimicrobial peptide, Homo sapiens, primates, mammals, animals|||Homo sapiens [Human]|||myosin 1H protein, intragenic antimicrobial peptide, Homo sapiens, primates, mammals, animals|||other methods predicted, predicted from the human unconventional myosin 1H protein, intragenic antimicrobial peptide, Homo sapiens, primates, mammals, animals Helix Judging by the peptide concentration that induces 50% hemolysis (Table 3, SC 50 ), Hs IAPs are in general as hemolytic as the reference AMP DS01 [27], in consonance with results obtained for other IAPs from plant proteins [7].|||Human erythrocytes (50% hemolysis at >128 uM)|||Human erythrocytes (50% hemolysis at >128 uM)|||human RBC: HC50 >128 uM. not hemo.lytic.|||human RBC: HC50 >128 uM. not hemo.lytic. PLoS One. 2019 Aug 6;14(8):e0220656. doi: 10.1371/journal.pone.0220656. PubMed|||31386688|||31386688|||PLoS One. 2019 Aug 6;14(8):e0220656. doi: 10.1371/journal.pone.0220656. PubMed|||PLoS One. 2019 Aug 6;14(8):e0220656. doi: 10.1371/journal.pone.0220656. PubMed 18 FPDB04031 AP03770|||Hs03|||Hs03|||AP03770|||AP03770 FLREFHKWIERVVGWLGKVF Anti-Gram+||Antifungal||candidacidal||Anti-C. albicans, activity value is MIC = 32 uM||Anti-T. rubrum, activity value is MIC = 256 uM||Anti-S. aureus, activity value is MIC = 32 uM||Anti-S. epidermidis, activity value is MIC = 21.33 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 32 uM||Anti-S. epidermidis, activity value is MIC = 21 uM||Anti-and C. albicans, activity value is MIC = 32 uM predicted intragenic antimicrobial peptide, predicted from the human unconventional myosin 1H protein, Homo sapiens, primates, mammals, animals|||Homo sapiens [Human]|||predicted from the human unconventional myosin 1H protein, Homo sapiens, primates, mammals, animals|||other methods predicted, predicted intragenic antimicrobial peptide, predicted from the human unconventional myosin 1H protein, Homo sapiens, primates, mammals, animals Helix Judging by the peptide concentration that induces 50% hemolysis (Table 3, SC 50 ), Hs IAPs are in general as hemolytic as the reference AMP DS01 [27], in consonance with results obtained for other IAPs from plant proteins [8].|||Human erythrocytes (50% hemolysis at >128 uM)|||Human erythrocytes (50% hemolysis at >128 uM)|||human RBC: HC50 >128 uM. not hemo.lytic.|||human RBC: HC50 >128 uM. not hemo.lytic. PLoS One. 2019 Aug 6;14(8):e0220656. doi: 10.1371/journal.pone.0220656. PubMed|||31386688|||31386688|||PLoS One. 2019 Aug 6;14(8):e0220656. doi: 10.1371/journal.pone.0220656. PubMed|||PLoS One. 2019 Aug 6;14(8):e0220656. doi: 10.1371/journal.pone.0220656. PubMed 20 FPDB04032 AP03771|||Hs04|||Hs04|||AP03771|||AP03771 LFNNYITAALKLLEKLYKV Anti-Gram+||Antifungal||candidacidal||Hemolytic||Anti-C. albicans, activity value is MIC = 8 uM||Anti-T. rubrum, activity value is MIC = 32 uM||Anti-S. aureus, activity value is MIC = 4 uM||Anti-S. epidermidis, activity value is MIC = 5.33 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 4 uM||Anti-and C. albicans, activity value is MIC = 8 uM predicted from the human unconventional myosin 1H protein, intragenic antimicrobial peptide, Homo sapiens, primates, mammals, animals|||Homo sapiens [Human]|||myosin 1H protein, intragenic antimicrobial peptide, Homo sapiens, primates, mammals, animals|||other methods predicted, predicted from the human unconventional myosin 1H protein, intragenic antimicrobial peptide, Homo sapiens, primates, mammals, animals Helix Judging by the peptide concentration that induces 50% hemolysis (Table 3, SC 50 ), Hs IAPs are in general as hemolytic as the reference AMP DS01 [27], in consonance with results obtained for other IAPs from plant proteins [9].|||Human erythrocytes (50% hemolysis at 64 uM)|||Human erythrocytes (50% hemolysis at 64 uM)|||human RBC: HC50 64 uM. hemolytic.|||human RBC: HC50 64 uM. hemolytic. PLoS One. 2019 Aug 6;14(8):e0220656. doi: 10.1371/journal.pone.0220656. PubMed|||31386688|||31386688|||PLoS One. 2019 Aug 6;14(8):e0220656. doi: 10.1371/journal.pone.0220656. PubMed|||PLoS One. 2019 Aug 6;14(8):e0220656. doi: 10.1371/journal.pone.0220656. PubMed 19 FPDB04119 AP03946 QNLCNIYYIQHADHCLAVINS active against Gram+ B.subtilis IA274 (- insignificant)||C. michiganensis (+++)||B.cereus 905 (-)||C. fangii (+++)||B. subtilis 330-2 (+)||B.subtilis RIK1285 (-)||B. subtilis 168 (+++)||Gram- X. oryzae pv. Oryzae (-)||X. oryzae pv. Oryzicola (+++)||R. solanacearum (+)||X. campestris pv. Holcicola (-). Bacteriostatic. screen from wild progenitor of bread wheat, Aegilops tauschii, plant-derived, natural derivatives|||screen from wild progenitor of bread wheat, Aegilops tauschii, plant-derived, natural derivatives N/A human RBC, 2.09% hemolysis at 1000 ug/ml (not hemo.lytic) Sci Rep. 2020 Aug 7;10(1):13346. doi: 10.1038/s41598-020-70314-5. PubMed|||Sci Rep. 2020 Aug 7;10(1):13346. doi: 10.1038/s41598-020-70314-5. PubMed 21 FPDB04120 AP03947 LCVSYSVRPSCKFVGRSNWKRNTCLEWCDQLFLFCFLIGGEMANS active against Gram+ B.subtilis IA274 (- insignificant)||C. michiganensis (+++)||B.cereus 905 (-)||C. fangii (+++ very significant)||B. subtilis 330-2 (+ significant)||B.subtilis RIK1285 (-)||B.subtilis 168 (-)||Gram- X. oryzae pv. Oryzae (+)||X. oryzae pv. Oryzicola (+++)||R. solanacearum (+)||X. campestris pv. Holcicola (-). Bacteriostatic. screen from wild progenitor of bread wheat, Aegilops tauschii, plant-derived, natural derivatives|||screen from wild progenitor of bread wheat, Aegilops tauschii, plant-derived, natural derivatives N/A human RBC (1%, incubation 1.5 h), 1.97% hemolysis at 1000 ug/ml (not hemo.lytic) Sci Rep. 2020 Aug 7;10(1):13346. doi: 10.1038/s41598-020-70314-5. PubMed|||Sci Rep. 2020 Aug 7;10(1):13346. doi: 10.1038/s41598-020-70314-5. PubMed 45 FPDB04121 AP03948 GVCRYHRQKWRTRGREWLRRC Anti-X. campestris pv. Holcicola, activity value is MIC = 4.25 uM||Anti-X. oryzae pv. oryzicola, activity value is MIC = 17 uM||Anti-X. oryzae pv. oryzae, activity value is MIC = 17 uM||Anti-and X. oryzae pv. oryzae, activity value is MIC = 8.5 uM Amino acid substitution of a machine learning predicted segment, AI predicted N/A sheep RBC: 4xMIC peptide (3.26% hemolysis). Microbiol Spectr. 2023 Dec 12;11(6):e0257823. doi: 10.1128/spectrum.02578-23. PubMed|||Microbiol Spectr. 2023 Dec 12;11(6):e0257823. doi: 10.1128/spectrum.02578-23. PubMed 21 FPDB04122 AP03949 RLARIWWIRWAR Anti-P. aeruginosa PAO1, activity value is MIC = 50 ug/ml||Anti-E. coli, activity value is MIC = 17 ug/ml||Anti-S. typhimurium, activity value is MIC = 34 ug/ml||Anti-S. aureus, activity value is MIC = 17 ug/ml||Anti-S. epidermidis, activity value is MIC = 4 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 17 ug/ml||Anti-and C. albicans, activity value is MIC = 9 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656|||Patent US9017656_ 12 FPDB04123 AP03950|||AP03951|||AP03950 QRLRIRVAVIRA Anti-P. aeruginosa PAO1, activity value is MIC = 50 ug/ml||Anti-E. coli, activity value is MIC = 6 ug/ml||Anti-S. typhimurium, activity value is MIC = 25 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-S. epidermidis, activity value is MIC = 12 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 50 ug/ml||Anti-and C. albicans, activity value is MIC = 25 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656|||Patent US9017656_ 12 FPDB04124 AP03952 WRFRIRWAWIRA Anti-P. aeruginosa PAO1, activity value is MIC = 6 ug/ml||Anti-E. coli, activity value is MIC = 1.6 ug/ml||Anti-S. typhimurium, activity value is MIC = 6 ug/ml||Anti-S. aureus, activity value is MIC = 12 ug/ml||Anti-S. epidermidis, activity value is MIC = 1.6 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 25 ug/ml||Anti-and C. albicans, activity value is MIC = 6 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04125 AP03953 WRWRIRWAWIRA Anti-P. aeruginosa PAO1, activity value is MIC = 6 ug/ml||Anti-E. coli, activity value is MIC = 1.6 ug/ml||Anti-S. typhimurium, activity value is MIC = 6 ug/ml||Anti-S. aureus, activity value is MIC = 12 ug/ml||Anti-S. epidermidis, activity value is MIC = 1.6 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 12 ug/ml||Anti-and C. albicans, activity value is MIC = 12 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04126 AP03954 WRLWIRWAWIRA Anti-P-aeruginosa PAO1, activity value is MIC > 50 ug/ml||Anti-E. coli, activity value is MIC = 6 ug/ml||Anti-S-typhimurium, activity value is MIC > 50 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-S. epidermidis, activity value is MIC = 3 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 25 ug/ml||Anti-and C. albicans, activity value is MIC = 50 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04127 AP03955 WRLRIRWWWIR Anti-P. aeruginosa PAO1, activity value is MIC = 12 ug/ml||Anti-E. coli, activity value is MIC = 3 ug/ml||Anti-S. typhimurium, activity value is MIC = 12 ug/ml||Anti-S. aureus, activity value is MIC = 6 ug/ml||Anti-S. epidermidis, activity value is MIC = 1.6 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 6 ug/ml||Anti-and C. albicans, activity value is MIC = 25 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 11 FPDB04128 AP03956 WRLRIRWAWRRA Anti-P. aeruginosa PAO1, activity value is MIC = 12 ug/ml||Anti-E. coli, activity value is MIC = 6 ug/ml||Anti-S. typhimurium, activity value is MIC = 6 ug/ml||Anti-S. aureus, activity value is MIC = 12 ug/ml||Anti-S. epidermidis, activity value is MIC = 1.6 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 25 ug/ml||Anti-and C. albicans, activity value is MIC = 6 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04129 AP03957 WRLRIRWAWIRK Anti-P. aeruginosa PAO1, activity value is MIC = 6 ug/ml||Anti-E. coli, activity value is MIC = 3 ug/ml||Anti-S. typhimurium, activity value is MIC = 6 ug/ml||Anti-S. aureus, activity value is MIC = 6 ug/ml||Anti-S. epidermidis, activity value is MIC = 1.6 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 12 ug/ml||Anti-and C. albicans, activity value is MIC = 3 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04130 AP03958|||AP03959|||CAMPSQ940|||DRAMP04027|||Opt1|||AP03958|||AP03958 VQLRIRVRVIRK Anti-P. aeruginosa PAO1, activity value is MIC = 6 ug/ml||Anti-E. coli, activity value is MIC = 3 ug/ml||Anti-S. typhimurium, activity value is MIC = 6 ug/ml||Anti-S. aureus, activity value is MIC = 12 ug/ml||Anti-S. epidermidis, activity value is MIC = 1.6 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 12 ug/ml||Anti-and C. albicans, activity value is MIC = 6 ug/ml||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 6 ug/ml||Anti-Escherichia coli, activity value is MIC = 3 ug/ml||Anti-Salmonella, activity value is MIC = 6 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 1.6 ug/ml||Antifungal Sequence variant of Bac2A, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||Sequence variant of Bac2A, animal-derived, natural derivative|||Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656|||17052614|||Chem Biol. 2006 Oct;13(10):1101-1107.|||17052614|||Patent US9017656|||Patent US9017656 12 FPDB04131 AP03960 WRLRIRWRWIRK Anti-P. aeruginosa PAO1, activity value is MIC = 3 ug/ml||Anti-E. coli, activity value is MIC = 1.6 ug/ml||Anti-S. typhimurium, activity value is MIC = 6 ug/ml||Anti-S. aureus, activity value is MIC = 6 ug/ml||Anti-S. epidermidis, activity value is MIC = 0.8 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 12 ug/ml||Anti-and C. albicans, activity value is MIC = 3 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04132 AP03961|||CAMPSQ9402|||DRAMP04029|||Opt3|||AP03961|||AP03961 KQFRIRVRVIRK Anti-P. aeruginosa PAO1, activity value is MIC = 6 ug/ml||Anti-E. coli, activity value is MIC = 3 ug/ml||Anti-S. typhimurium, activity value is MIC = 6 ug/ml||Anti-S. aureus, activity value is MIC = 12 ug/ml||Anti-S. epidermidis, activity value is MIC = 1.6 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 25 ug/ml||Anti-and C. albicans, activity value is MIC = 6 ug/ml||Antibacterial||Antifungal||Anti-Pseudomonas aeruginosa, activity value is MIC = 6 ug/ml||Anti-Escherichia coli, activity value is MIC = 3 ug/ml||Anti-Salmonella, activity value is MIC = 6 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 1.6 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||Sequence variant of Bac2A, animal-derived, natural derivative|||Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656|||17052614|||Chem Biol. 2006 Oct;13(10):1101-1107.|||17052614|||Patent US9017656|||Patent US9017656 12 FPDB04133 AP03962|||CAMPSQ20418|||Undefined|||AP03962|||AP03962 HQFRFRFRVRRK Anti-P. aeruginosa PAO1, activity value is MIC = 6 ug/ml||Anti-E. coli, activity value is MIC = 3 ug/ml||Anti-S. typhimurium, activity value is MIC = 6 ug/ml||Anti-S. aureus, activity value is MIC = 12 ug/ml||Anti-S. epidermidis, activity value is MIC = 1.6 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 25 ug/ml||Anti-and C. albicans, activity value is MIC = 6 ug/ml||Antibacterial||Antifungal Sequence variant of Bac2A, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||Sequence variant of Bac2A, animal-derived, natural derivative|||Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656|||23478953|||23478953|||Patent US9017656|||Patent US9017656 12 FPDB04134 AP03963 HQWRIRVAVRRH Anti-P. aeruginosa PAO1, activity value is MIC = 50 ug/ml||Anti-E. coli, activity value is MIC = 6 ug/ml||Anti-S. typhimurium, activity value is MIC = 25 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-S. epidermidis, activity value is MIC = 12 ug/ml||Anti-E-faecalis ATCC29212, activity value is MIC > 25 ug/ml||Anti-and C. albicans, activity value is MIC = 25 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04135 AP03964 KRFRIRWRWIRK Anti-P. aeruginosa PAO1, activity value is MIC = 6 ug/ml||Anti-E. coli, activity value is MIC = 1.6 ug/ml||Anti-S. typhimurium, activity value is MIC = 3 ug/ml||Anti-S. aureus, activity value is MIC = 6 ug/ml||Anti-S. epidermidis, activity value is MIC = 0.8 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 25 ug/ml||Anti-and C. albicans, activity value is MIC = 12 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04136 AP03965 KRWRIRWRWIRK Anti-P. aeruginosa PAO1, activity value is MIC = 3 ug/ml||Anti-E. coli, activity value is MIC = 1.6 ug/ml||Anti-S. typhimurium, activity value is MIC = 3 ug/ml||Anti-S. aureus, activity value is MIC = 3 ug/ml||Anti-S. epidermidis, activity value is MIC = 0.8 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 12 ug/ml||Anti-and C. albicans, activity value is MIC = 6 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04137 AP03966 IWWIWRR Anti-P. aeruginosa PAO1, activity value is MIC = 50 ug/ml||Anti-E. coli, activity value is MIC = 6 ug/ml||Anti-S. typhimurium, activity value is MIC = 12.5 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-S. epidermidis, activity value is MIC = 6 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 25 ug/ml||Anti-and C. albicans, activity value is MIC = 25 ug/ml Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017656 7 FPDB04138 AP03967 ILPWKFPWWPWRR Anti-P. aeruginosa PAO1, activity value is MIC = 62 ug/ml||Anti-E. coli, activity value is MIC = 8 ug/ml||Anti-S. typhimurium, activity value is MIC = 31 ug/ml||Anti-S. aureus, activity value is MIC = 16 ug/ml||Anti-S. epidermidis, activity value is MIC = 8 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 31 ug/ml||Anti-and C. albicans, activity value is MIC = 16 ug/ml Amino acid substitution of indolicidin, bovine cathelicidin analog, animal-derived, natural derivative Rich N/A Patent US9017656 13 FPDB04139 AP03968 ILPWKKPWWPWRR Anti-P. aeruginosa PAO1, activity value is MIC = 31 ug/ml||Anti-E. coli, activity value is MIC = 31 ug/ml||Anti-S. typhimurium, activity value is MIC = 62 ug/ml||Anti-S. aureus, activity value is MIC = 31 ug/ml||Anti-S. epidermidis, activity value is MIC = 8 ug/ml||Anti-E.faecalis ATCC29212, activity value is MIC = 125 ug/ml||Anti-and C. albicans, activity value is MIC = 62 ug/ml Amino acid substitution of indolicidin, bovine cathelicidin analog, animal-derived, natural derivative Rich N/A Patent US9017656 13 FPDB04140 AP03969|||CAMPSQ15241|||AP03969|||DRAMP21042 ILPWKWPWWKWRR Anti-P. aeruginosa PAO1, activity value is MIC = 16 ug/ml||Anti-E. coli, activity value is MIC = 8 ug/ml||Anti-S. typhimurium, activity value is MIC = 31 ug/ml||Anti-S. aureus, activity value is MIC = 8 ug/ml||Anti-S. epidermidis, activity value is MIC = 2 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 31 ug/ml||Anti-and C. albicans, activity value is MIC = 16 ug/ml||Anti-E. coli, activity value is MIC = 20 ug/ml||Anti-P. aeruginosa, activity value is MIC = 20 ug/ml||Anti-S. typhimurium, activity value is MIC = 10 ug/ml||Anti-B. subtilis, activity value is MIC = 10 ug/ml||Anti-S. epidermidis, activity value is MIC = 10 ug/ml||Anti-S. aureus, activity value is MIC = 5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 10 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 5 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 20 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 20 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 10 ug/ml Amino acid substitution of indolicidin, bovine cathelicidin analog, animal-derived, natural derivative|||Bos taurus [Bovine]|||Amino acid substitution of indolicidin, bovine cathelicidin analog, animal-derived, natural derivative|||Synthetic construct Rich hRBC ( HC50= 490 ug/ml)|||[Ref.19428758] HC50=490 ug/ml against human red blood cells Patent US9017656|||19428758|||Patent US9017656|||Peptides. 2009 May;30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.||Ref.19428758 13 FPDB04141 AP03970 ILPWWWPWWPWRR Anti-P-aeruginosa PAO1, activity value is MIC > 84 ug/ml||Anti-E-coli, activity value is MIC > 84 ug/ml||Anti-S-typhimurium, activity value is MIC > 84 ug/ml||Anti-S. aureus, activity value is MIC = 20 ug/ml||Anti-S. epidermidis, activity value is MIC = 5 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 84 ug/ml||Anti-and C. albicans, activity value is MIC = 84 ug/ml Amino acid substitution of indolicidin, bovine cathelicidin analog, animal-derived, natural derivative Rich N/A Patent US9017656 13 FPDB04142 AP03971|||CAMPSQ15245|||AP03971|||DRAMP21046 ILKWKWPWWKWRR Anti-P. aeruginosa PAO1, activity value is MIC = 16 ug/ml||Anti-E. coli, activity value is MIC = 8 ug/ml||Anti-S. typhimurium, activity value is MIC = 16 ug/ml||Anti-S. aureus, activity value is MIC = 8 ug/ml||Anti-S. epidermidis, activity value is MIC = 2 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 31 ug/ml||Anti-and C. albicans, activity value is MIC = 16 ug/ml||Anti-E. coli, activity value is MIC = 10 ug/ml||Anti-P. aeruginosa, activity value is MIC = 10 ug/ml||Anti-S. typhimurium, activity value is MIC = 10 ug/ml||Anti-B. subtilis, activity value is MIC = 5 ug/ml||Anti-S. epidermidis, activity value is MIC = 10 ug/ml||Anti-S. aureus, activity value is MIC = 5 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 5 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 5 ug/ml||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 10 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 10 ug/ml Amino acid substitution of indolicidin, bovine cathelicidin analog, animal-derived, natural derivative|||Bos taurus [Bovine]|||Amino acid substitution of indolicidin, bovine cathelicidin analog, animal-derived, natural derivative|||Synthetic construct Rich hRBC ( HC50= >800 ug/ml)|||[Ref.19428758] HC50>800 ug/ml against human red blood cells Patent US9017656|||19428758|||Patent US9017656|||Peptides. 2009 May;30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.||Ref.19428758 13 FPDB04143 AP03972 FLPKKFRWWKYRK Anti-P. aeruginosa PAO1, activity value is MIC = 31 ug/ml||Anti-E. coli, activity value is MIC = 16 ug/ml||Anti-S. typhimurium, activity value is MIC = 31 ug/ml||Anti-S. aureus, activity value is MIC = 31 ug/ml||Anti-S. epidermidis, activity value is MIC = 8 ug/ml||Anti-E.faecalis ATCC29212, activity value is MIC > 125 ug/ml||Anti-and C. albicans, activity value is MIC = 31 ug/ml Amino acid substitution of indolicidin, bovine cathelicidin analog, animal-derived, natural derivative N/A N/A Patent US9017656 13 FPDB04144 AP03973 FIKWKFRWWKWR Anti-P. aeruginosa PAO1, activity value is MIC = 8 ug/ml||Anti-E. coli, activity value is MIC = 4 ug/ml||Anti-S. typhimurium, activity value is MIC = 8 ug/ml||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-S. epidermidis, activity value is MIC = 2 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 8 ug/ml||Anti-and C. albicans, activity value is MIC = 8 ug/ml Amino acid substitution of indolicidin, bovine cathelicidin analog, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04145 AP03974 LPWKWRWWKWRR Anti-P. aeruginosa PAO1, activity value is MIC = 16 ug/ml||Anti-E. coli, activity value is MIC = 8 ug/ml||Anti-S. typhimurium, activity value is MIC = 16 ug/ml||Anti-S. aureus, activity value is MIC = 8 ug/ml||Anti-S. epidermidis, activity value is MIC = 2 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 31 ug/ml||Anti-and C. albicans, activity value is MIC = 8 ug/ml Amino acid substitution of indolicidin, bovine cathelicidin analog, animal-derived, natural derivative Rich N/A Patent US9017656 12 FPDB04178 AP04033|||CAMPSQ23275|||AP04033|||DRAMP29123 LNLKKLLAVAKKIL Anti-Gram+ S. aureus ATCC 25923, activity value is MIC = 64 uM||Anti-B. cereus ATCC 11778, activity value is MIC = 16 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 8 uM||Anti-L. monocytogenes ATCC 15313, activity value is MIC = 8 uM||Anti-E. coli ATCC 25922, activity value is MIC = 8 uM||Anti-P.aeruginosa ATCC 27853, activity value is MIC = 128 uM||Anti-S. enterica ATCC 13076, activity value is MIC = 64 uM||Anti-and fungi C. albicans ATCC 10231, activity value is MIC = 32 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 8 uM||Anti-Bacillus subtilis ATCC 23857, activity value is MIC = 2 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 4 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 4 uM||Anti-Klebsiella pneumoniae ATCC 700603, activity value is MIC = 4 uM||Anti-##Gram-negative bacteria:Escherichia coli ATCC 25922, activity value is MIC = 4 uM Amino acid substitution|||Synthetic construct|||Amino acid substitution|||Synthetic construct Alpha helix,random coil human RBC, HC50 ~64 uM, hemolytic.|||Mouse erythrocytes (10% Hemolysis at 128 uM|||human RBC, HC50 ~64 uM, hemolytic.|||[Ref.33285267]10% hemolysis against mouse erythrocytes at 128 uM,30% hemolysis against mouse erythrocytes at 256 uM. ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed|||33285267|||ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed|||Eur J Pharm Sci. 2021 Mar 1;158:105665.||Ref.33285267|||ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed 14 FPDB04179 AP04034 LNLKALLKVAKKIL Anti-Gram+ S. aureus ATCC 25923, activity value is MIC = 32 uM||Anti-B. cereus ATCC 11778, activity value is MIC = 8 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 4 uM||Anti-L. monocytogenes ATCC 15313, activity value is MIC = 4 uM||Anti-E. coli ATCC 25922, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 64 uM||Anti-S. enterica ATCC 13076, activity value is MIC = 64 uM||Anti-and fungi C. albicans ATCC 10231, activity value is MIC = 16 uM Amino acid substitution N/A human RBC, HC50 ~64 uM, hemolytic. ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed|||ACS Med Chem Lett. 2023 Dec 22;15(1):69-75. doi: 10.1021/acsmedchemlett.3c00385. PubMed 14 FPDB04181 AP04041|||Anal 1|||DRAMP04076|||Anal 1|||AP04041|||AP04041 AKKVFKRLEKLFSKIQNWK Anti-Gram+ B. subtilis, activity value is MIC = 0.78 uM||Anti-S. epidermidis, activity value is MIC = 1.56 uM||Anti-S. aureus, activity value is MIC = 12.5 uM||Anti-E. coli, activity value is MIC = 12.5 uM||Anti-P. vulgaris, activity value is MIC = 6.25 uM||Anti-and P. aeruginosa, activity value is MIC = 12.5 uM||Anti-B. subtilis, activity value is MIC = 1.56 uM||Anti-S. epidermidis, activity value is MIC = 3.13 uM||Anti-S. aureus, activity value is MIC = 3.13 uM||Anti-E. coli, activity value is MIC = 0.78 uM||Anti-S. typhimurium, activity value is MIC = 0.39 uM||Anti-P. vulgaris, activity value is MIC = 3.13 uM||Anti-P. aeruginosa, activity value is MIC = 3.13 uM||Anti-E. coli O157, activity value is MIC = 6.25 uM||Anti-L. monocytogenes, activity value is MIC = 0.78 uM||Anti-T. beigelii, activity value is MIC = 1.56 uM||Anti-C. albicans, activity value is MIC = 25 uM||Anti-S. cerevisiae, activity value is MIC = 25 uM||Anti-A. flavus, activity value is MIC = 50 uM||Anti-A. fumigatus, activity value is MIC = 50 uM||Anti-F. moniliforme, activity value is MIC = 12.5 uM||Anti-B. cinerea, activity value is MIC = 6.25 uM||Anti-Bacillus subtilis, activity value is MIC = 1.56 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 3.13 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3.13 ug/ml||Anti-Listeria monocytogenes, activity value is MIC = 0.78 ug/ml||Anti-Escherichia coli, activity value is MIC = 0.78 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 0.39 ug/ml||Anti-Proteus vulgaris, activity value is MIC = 3.13 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 3.13 ug/ml||Anti-Escherichia coli O157, activity value is MIC = 6.25 ug/ml||Anti-Candida albicans, activity value is MIC = 25 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC = 25 ug/ml||Anti-Aspergillus flavus, activity value is MIC = 50 ug/ml||Anti-Aspergillus fumigatus, activity value is MIC > 50 ug/ml||Anti-Botrytis cinerea, activity value is MIC = 6.25 ug/ml||Anti-Fusarium moniliforme, activity value is MIC = 12.5 ug/ml||Anti-T. beigelii, activity value is MIC = 6.25 uM||Anti-and S. cerevisiae, activity value is MIC = 12.5 uM Amino acid substitution|||Synthetic construct|||Synthetic construct (amino acid substitution)|||Amino acid substitution|||Amino acid substitution Helix||Alpha helix (1 helices; 14 residues) not hemo.lytic at 100 uM (0% hemolysis). Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed|||16255716|||Biochem J. 2006 Feb 15;394(Pt 1):105-114.|||16255716|||Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed|||Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed 19 FPDB04182 AP04042|||Anal 2|||DRAMP04077|||Anal 2|||AP04042|||AP04042 AKKVFKRLEKLFSKIWNDK Anti-Gram+ B. subtilis, activity value is MIC = 0.78 uM||Anti-S. epidermidis, activity value is MIC = 1.56 uM||Anti-S. aureus, activity value is MIC = 6.25 uM||Anti-E. coli, activity value is MIC = 3.12 uM||Anti-P. vulgaris, activity value is MIC = 3.12 uM||Anti-and P. aeruginosa, activity value is MIC = 6.25 uM||Anti-B. subtilis, activity value is MIC = 1.56 uM||Anti-S. epidermidis, activity value is MIC = 3.13 uM||Anti-E. coli, activity value is MIC = 3.13 uM||Anti-S. typhimurium, activity value is MIC = 0.78 uM||Anti-P. vulgaris, activity value is MIC = 3.13 uM||Anti-P. aeruginosa, activity value is MIC = 6.25 uM||Anti-E. coli O157, activity value is MIC = 6.25 uM||Anti-L. monocytogenes, activity value is MIC = 1.56 uM||Anti-T. beigelii, activity value is MIC = 1.56 uM||Anti-C. albicans, activity value is MIC = 25 uM||Anti-S. cerevisiae, activity value is MIC = 25 uM||Anti-A. flavus, activity value is MIC = 50 uM||Anti-A. fumigatus, activity value is MIC = 50 uM||Anti-F. moniliforme, activity value is MIC = 25 uM||Anti-B. cinerea, activity value is MIC = 6.25 uM||Anti-Bacillus subtilis, activity value is MIC = 1.56 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 3.13 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 6.25 ug/ml||Anti-Listeria monocytogenes, activity value is MIC = 1.56 ug/ml||Anti-Escherichia coli, activity value is MIC = 3.13 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 0.78 ug/ml||Anti-Proteus vulgaris, activity value is MIC = 3.13 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 6.25 ug/ml||Anti-Escherichia coli O157, activity value is MIC = 6.25 ug/ml||Anti-Candida albicans, activity value is MIC = 25 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC = 25 ug/ml||Anti-Aspergillus flavus, activity value is MIC = 50 ug/ml||Anti-Aspergillus fumigatus, activity value is MIC > 50 ug/ml||Anti-Botrytis cinerea, activity value is MIC = 6.25 ug/ml||Anti-Fusarium moniliforme, activity value is MIC = 25 ug/ml||Anti-T. beigelii, activity value is MIC = 6.25||Anti-and S. cerevisiae, activity value is MIC = 12.5 uM Amino acid substitution|||Synthetic construct|||Synthetic construct (amino acid substitution)|||Amino acid substitution|||Amino acid substitution Helix||Alpha helix (1 helices; 14 residues) not hemo.lytic at 100 uM (0% hemolysis). Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed|||16255716|||Biochem J. 2006 Feb 15;394(Pt 1):105-114.|||16255716|||Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed|||Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed 19 FPDB04183 AP04043|||Anal 3|||DRAMP04078|||Anal 3|||AP04043|||AP04043 AKKVFKRLEKLFSKIWNWK Anti-Gram+ B. subtilis, activity value is MIC = 0.39 uM||Anti-S. epidermidis, activity value is MIC = 0.78 uM||Anti-S. aureus, activity value is MIC = 0.78 uM||Anti-E. coli, activity value is MIC = 1.56 uM||Anti-P. vulgaris, activity value is MIC = 0.39 uM||Anti-and P. aeruginosa, activity value is MIC = 1.56 uM||Anti-B. subtilis, activity value is MIC = 1.56 uM||Anti-S. epidermidis, activity value is MIC = 3.13 uM||Anti-S. aureus, activity value is MIC = 1.56 uM||Anti-S. typhimurium, activity value is MIC = 0.39 uM||Anti-P. vulgaris, activity value is MIC = 3.13 uM||Anti-P. aeruginosa, activity value is MIC = 3.13 uM||Anti-E. coli O157, activity value is MIC = 3.13 uM||Anti-L. monocytogenes, activity value is MIC = 0.39 uM||Anti-T. beigelii, activity value is MIC = 1.56 uM||Anti-C. albicans, activity value is MIC = 12.5 uM||Anti-S. cerevisiae, activity value is MIC = 25 uM||Anti-A. flavus, activity value is MIC = 25 uM||Anti-A. fumigatus, activity value is MIC = 25 uM||Anti-F. moniliforme, activity value is MIC = 12.5 uM||Anti-B. cinerea, activity value is MIC = 3.13 uM||Anti-Bacillus subtilis, activity value is MIC = 1.56 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 3.13 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 1.56 ug/ml||Anti-Listeria monocytogenes, activity value is MIC = 0.39 ug/ml||Anti-Escherichia coli, activity value is MIC = 1.56 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 0.39 ug/ml||Anti-Proteus vulgaris, activity value is MIC = 3.13 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 3.13 ug/ml||Anti-Escherichia coli O157, activity value is MIC = 3.13 ug/ml||Anti-Candida albicans, activity value is MIC = 12.5 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC = 25 ug/ml||Anti-Aspergillus flavus, activity value is MIC = 25 ug/ml||Anti-Aspergillus fumigatus, activity value is MIC = 25 ug/ml||Anti-Botrytis cinerea, activity value is MIC = 3.13 ug/ml||Anti-Fusarium moniliforme, activity value is MIC = 12.5 ug/ml||Anti-T. beigelii, activity value is MIC = 3.12 uM||Anti-and S. cerevisiae, activity value is MIC = 3.12 Amino acid substitution|||Synthetic construct|||Synthetic construct (amino acid substitution)|||Amino acid substitution|||Amino acid substitution Helix||Alpha helix (1 helices; 14 residues) not hemo.lytic at 100 uM (0% hemolysis).|||Human erythrocytes (Non-hemolytic upto 100 uM)|||Human erythrocytes (Non-hemolytic upto 100 uM)|||not hemo.lytic at 100 uM (0% hemolysis).|||not hemo.lytic at 100 uM (0% hemolysis). Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed|||16255716|||Biochem J. 2006 Feb 15;394(Pt 1):105-114.|||16255716|||Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed|||Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed 19 FPDB04184 AP04044|||Anal 4|||DRAMP04079|||Anal 4|||AP04044|||AP04044 AKKVFKRLEKSFSKIQNDK Anti-Gram+ B. subtilis, activity value is MIC = 12.5 uM||Anti-S. epidermidis, activity value is MIC = 50 uM||Anti-S. aureus, activity value is MIC = 50 uM||Anti-E. coli, activity value is MIC = 25 uM||Anti-P. vulgaris, activity value is MIC = 12.5 uM||Anti-and P. aeruginosa, activity value is MIC = 25 uM||Anti-B. subtilis, activity value is MIC = 6.25 uM||Anti-E. coli, activity value is MIC = 12.5 uM||Anti-S. typhimurium, activity value is MIC = 12.5 uM||Anti-P. aeruginosa, activity value is MIC = 12.5 uM||Anti-T. beigelii, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC > 12.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC > 12.5 ug/ml||Anti-Listeria monocytogenes, activity value is MIC > 12.5 ug/ml||Anti-Escherichia coli, activity value is MIC = 12.5 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 12.5 ug/ml||Anti-Proteus vulgaris, activity value is MIC > 12.5 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 12.5 ug/ml||Anti-Escherichia coli O157, activity value is MIC > 12.5 ug/ml||Anti-Candida albicans, activity value is MIC > 25 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC > 25 ug/ml||Anti-Aspergillus flavus, activity value is MIC > 50 ug/ml||Anti-Aspergillus fumigatus, activity value is MIC > 50 ug/ml||Anti-Botrytis cinerea, activity value is MIC > 50 ug/ml||Anti-Fusarium moniliforme, activity value is MIC > 50 ug/ml||Anti-T. beigelii, activity value is MIC = 50 uM||Anti-and S. cerevisiae, activity value is MIC = 50 uM Amino acid substitution|||Synthetic construct|||Synthetic construct (amino acid substitution)|||Amino acid substitution|||Amino acid substitution Helix||Alpha helix (1 helices; 13 residues) not hemo.lytic at 100 uM (0% hemolysis). Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed|||16255716|||Biochem J. 2006 Feb 15;394(Pt 1):105-114.|||16255716|||Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed|||Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed 19 FPDB04185 AP04045|||Anal 5|||DRAMP04080|||Anal 5|||AP04045|||AP04045 AKKVSKRLEKLFSKIQNDK Anti-Gram+ B. subtilis, activity value is MIC = 6.25 uM||Anti-S. epidermidis, activity value is MIC = 12.5 uM||Anti-S. aureus, activity value is MIC = 50 uM||Anti-E. coli, activity value is MIC = 12.5 uM||Anti-P. vulgaris, activity value is MIC = 12.5 uM||Anti-and P. aeruginosa, activity value is MIC = 25 uM||Anti-B. subtilis, activity value is MIC = 3.13 uM||Anti-S. subtilisepidermidis, activity value is MIC = 12.5 uM||Anti-E. coli, activity value is MIC = 6.25 uM||Anti-S. typhimurium, activity value is MIC = 12.5 uM||Anti-P. aeruginosa, activity value is MIC = 12.5 uM||Anti-E. coli O157, activity value is MIC = 6.25 uM||Anti-T. beigelii, activity value is MIC = 12.5 uM||Anti-Bacillus subtilis, activity value is MIC = 3.13 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC > 12.5 ug/ml||Anti-Listeria monocytogenes, activity value is MIC > 12.5 ug/ml||Anti-Escherichia coli, activity value is MIC = 6.25 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 12.5 ug/ml||Anti-Proteus vulgaris, activity value is MIC > 12.5 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 12.5 ug/ml||Anti-Escherichia coli O157, activity value is MIC = 6.25 ug/ml||Anti-Candida albicans, activity value is MIC > 25 ug/ml||Anti-Saccharomyces cerevisiae, activity value is MIC > 25 ug/ml||Anti-Aspergillus flavus, activity value is MIC > 50 ug/ml||Anti-Aspergillus fumigatus, activity value is MIC > 50 ug/ml||Anti-Botrytis cinerea, activity value is MIC > 50 ug/ml||Anti-Fusarium moniliforme, activity value is MIC > 50 ug/ml||Anti-T. beigelii, activity value is MIC = 50 uM||Anti-and S. cerevisiae, activity value is MIC = 50 Amino acid substitution|||Synthetic construct|||Synthetic construct (amino acid substitution)|||Amino acid substitution|||Amino acid substitution Helix||Alpha helix (1 helices; 12 residues) not hemo.lytic at 100 uM (0% hemolysis). Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed|||16255716|||Biochem J. 2006 Feb 15;394(Pt 1):105-114.|||16255716|||Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed|||Biochim Biophys Acta. 2002 Jul 29;1598(1-2):185-94. doi: 10.1016/s0167-4838(02)00373-4. PubMed 19 FPDB04273 AP04208 CSSGSLWRLIRRFLRR Anti-Gram-||Antifungal||candidacidal||Anti-99 clinical isolates C. albicans, activity value is MIC = 0.391||Anti-ECV 95%: 12.5 ug/ml. cf: strain C. albicans ATCC 10231, activity value is MIC = 6.25 ug/ml||Anti-106 clinical isolates C. auris, activity value is MIC = 0.391||Anti-2024). Additional antifungal assays against 10 strains Cryptococcus C. neoformans, activity value is MIC = 6.25||Anti-10 strains C. gattii, activity value is MIC = 3.125||Anti-Candida 28 strains C. parapsilosis, activity value is MIC = 0.391||Anti-18 strains C. glabrata, activity value is MIC = 0.391||Anti-17 strains C. tropicalis, activity value is MIC = 0.391||Anti-4 strains C. dubliniensis and C. krusei, activity value is MIC = 0.391 ug/ml designed N/A N/A Int J Mol Sci. 2023 Mar 2;24(5):4800. doi: 10.3390/ijms24054800. PubMed|||Int J Mol Sci. 2023 Mar 2;24(5):4800. doi: 10.3390/ijms24054800. PubMed||Firacative et al., 2025 16 FPDB04276 AP04211|||CAMPSQ9391|||CAMPSQ10460|||DRAMP03870|||Bac2A|||AP04211 RLARIVVIRVAR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 50 ug/ml||Anti-Escherichia coli, activity value is MIC = 17 ug/ml||Anti-Salmonella, activity value is MIC = 34 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 17 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 4 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 17 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 50 uM||Anti-E. coli, activity value is MIC = 17 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 34 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 4 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 17 uM||Anti-and C. albicans, activity value is MIC = 9 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||17052614|||30917919|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.Chem Biol. 2006 Oct;13(10):1101-1107.|||17052614|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04278 AP04213|||CAMPSQ9235|||DRAMP03853|||G2|||AP04213 RGARIVVIRVAR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 31 ug/ml||Anti-Escherichia coli, activity value is MIC = 8 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 31 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 31 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 16 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 31 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 31 uM||Anti-E. coli, activity value is MIC = 8 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 31 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 16 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 31 uM||Anti-and C. albicans, activity value is MIC = 16 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04279 AP04214|||CAMPSQ9236|||DRAMP03854|||R2|||AP04214 RRARIVVIRVAR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 ug/ml||Anti-Escherichia coli, activity value is MIC = 4 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 2 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 8 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 2 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 16 uM||Anti-and C. albicans, activity value is MIC = 8 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04280 AP04215|||CAMPSQ9237|||DRAMP03855|||R3|||AP04215 RLRRIVVIRVAR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 ug/ml||Anti-Escherichia coli, activity value is MIC = 4 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 2 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 8 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 2 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 16 uM||Anti-and C. albicans, activity value is MIC = 8 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04281 AP04216|||CAMPSQ9238|||DRAMP03856|||W3|||AP04216 RLWRIVVIRVAR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 ug/ml||Anti-Escherichia coli, activity value is MIC = 2 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 0.5 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 2 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 8 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 0.5 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 2 uM||Anti-and C. albicans, activity value is MIC = 8 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04283 AP04218|||CAMPSQ9240|||DRAMP03858|||K7|||AP04218 RLARIVKIRVAR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 31 ug/ml||Anti-Escherichia coli, activity value is MIC = 16 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 63 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 125 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 31 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 125 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 31 uM||Anti-E. coli, activity value is MIC = 16 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 63 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 31 uM||Anti-E.faecalis ATCC29212, activity value is MIC = 125 uM||Anti-and C. albicans, activity value is MIC = 31 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04284 AP04219|||CAMPSQ9241|||DRAMP03859|||W10|||AP04219 RLARIVVIRWAR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 16 ug/ml||Anti-Escherichia coli, activity value is MIC = 4 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 2 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 16 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 8 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 2 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 4 uM||Anti-and C. albicans, activity value is MIC = 8 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04285 AP04220|||CAMPSQ9242|||DRAMP03860|||R11|||AP04220 RLARIVVIRVRR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 16 ug/ml||Anti-Escherichia coli, activity value is MIC = 8 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 2 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 16 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 8 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 2 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 4 uM||Anti-and C. albicans, activity value is MIC = 8 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04286 AP04221|||CAMPSQ9243|||DRAMP03861|||G12|||AP04221 RLARIVVIRVAG Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 63 ug/ml||Anti-Escherichia coli, activity value is MIC = 16 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 63 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 63 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 31 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 31 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 63 uM||Anti-E. coli, activity value is MIC = 16 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 63 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 31 uM||Anti-E.faecalis ATCC29212, activity value is MIC = 31 uM||Anti-and C. albicans, activity value is MIC = 63 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04287 AP04222|||CAMPSQ9244|||DRAMP03862|||Sub2|||AP04222 RLRRIVVIRVRR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 ug/ml||Anti-Escherichia coli, activity value is MIC = 2 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 2 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 4 ug/ml||Anti-ctive against P. aeruginosa H103, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 2 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 8 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 2 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 4 uM||Anti-and C. albicans, activity value is MIC = 31 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04288 AP04223|||CAMPSQ9245|||CAMPSQ10083|||DRAMP03863|||Sub3|||AP04223 RRWRIVVIRVRR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 2 ug/ml||Anti-Escherichia coli, activity value is MIC = 2.5 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 0.2 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 2 uM||Anti-E. coli, activity value is MIC = 0.5 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 4 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 0.2 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 4 uM||Anti-and C. albicans, activity value is MIC = 4 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||31616307|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04289 AP04224|||CAMPSQ9246|||CAMPSQ11347|||DRAMP03864|||Sub5|||AP04224 RRWKIVVIRWRR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 2 ug/ml||Anti-Escherichia coli, activity value is MIC = 4 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 0.5 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 2 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 8 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 0.5 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 2 uM||Anti-and C. albicans, activity value is MIC = 4 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||30742402|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04290 AP04225|||CAMPSQ9247|||DRAMP03865|||Sub6|||AP04225 RWWKIWVIRWWR Anti-Gram+ & Gram-||Antifungal||candidacidal||Antibacterial||Anti-Pseudomonas aeruginosa, activity value is MIC = 31 ug/ml||Anti-Escherichia coli, activity value is MIC = 4 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 1 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 31 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 16 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 1 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 8 uM||Anti-and C. albicans, activity value is MIC = 31 uM amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||amino acid substitution, animal-derived, natural derivative N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 12 FPDB04291 AP04226|||Bac8a|||DRAMP03866|||Bac8a|||AP04226 KIWVIRWR Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Pseudomonas aeruginosa, activity value is MIC = 16 ug/ml||Anti-Escherichia coli, activity value is MIC = 8 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 31 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 4 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 16 ug/ml||Anti-Candida albicans, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa H103, activity value is MIC = 16 uM||Anti-E. coli, activity value is MIC = 8 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 31 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 4 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 16 uM||Anti-and C. albicans, activity value is MIC = 16 uM sequence truncation, amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||sequence truncation, amino acid substitution, animal-derived, natural N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||https://pubmed.ncbi.nlm.nih.gov/16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 8 FPDB04292 AP04227|||Bac8b|||DRAMP03867|||Bac8b|||AP04227 RIWVIRWR Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Pseudomonas aeruginosa, activity value is MIC = 16 ug/ml||Anti-Escherichia coli, activity value is MIC = 4 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 4 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 8 ug/ml||Anti-Candida albicans, activity value is MIC = 16 ug/ml||Anti-Candida albicans, activity value is MIC = 50 uM||Anti-P. aeruginosa H103, activity value is MIC = 16 uM||Anti-E. coli, activity value is MIC = 4 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 16 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 4 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 8 uM||Anti-and C. albicans, activity value is MIC = 16 uM sequence truncation, amino acid substitution, animal-derived, natural derivative|||Synthetic construct N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||https://pubmed.ncbi.nlm.nih.gov/16041366|||https://pubmed.ncbi.nlm.nih.gov/28105725|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 8 FPDB04293 AP04228|||Bac8c|||DRAMP03868|||Bac8c|||AP04228 RIWVIWRR Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 ug/ml||Anti-Escherichia coli, activity value is MIC = 2 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 2 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 2 ug/ml||Anti-Candida albicans, activity value is MIC = 8 ug/ml||Anti-Candida albicans, activity value is MIC = 25 uM||Anti-P. aeruginosa H103, activity value is MIC = 8 uM||Anti-E. coli, activity value is MIC = 2 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 8 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 4 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 8 uM||Anti-and C. albicans, activity value is MIC = 16 uM sequence truncation, amino acid substitution, animal-derived, natural derivative|||Synthetic construct N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||https://pubmed.ncbi.nlm.nih.gov/16041366|||https://pubmed.ncbi.nlm.nih.gov/28105725|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 8 FPDB04294 AP04229|||Bac8d|||DRAMP03869|||Bac8d|||AP04229 RRWVIWRR Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Pseudomonas aeruginosa, activity value is MIC = 250 ug/ml||Anti-Escherichia coli, activity value is MIC = 16||Anti-Salmonella typhimurium, activity value is MIC = 31 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 16 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 8 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 32 ug/ml||Anti-Candida albicans, activity value is MIC = 63 ug/ml||Anti-Escherichia coli, activity value is MIC = 16 ug/ml||Anti-P.aeruginosa H103, activity value is MIC = 250 uM||Anti-E. coli, activity value is MIC = 16 uM||Anti-S. enterica ssp. Typhimurium or S. Typhimurium, activity value is MIC = 31 uM||Anti-S. epidermidis clinical strain, activity value is MIC = 8 uM||Anti-E. faecalis ATCC29212, activity value is MIC = 32 uM||Anti-and C. albicans, activity value is MIC = 63 uM sequence truncation, amino acid substitution, animal-derived, natural derivative|||Synthetic construct N/A N/A Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed|||16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-1012.|||https://pubmed.ncbi.nlm.nih.gov/16041366|||Nat Biotechnol. 2005 Aug;23(8):1008-12. doi: 10.1038/nbt1113. PubMed 8 FPDB04387 AP04629|||LL-37 KR-12|||DRAMP35630 KRIVKRIKKFLR active against E. coli||P. aeruginosa||S. aureus||and C. albicans. Warning: Non-standard assay.||Antibacterial||Antifungal||Antimicrobial||Anticancer amino acid substitution, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic Helix N/A Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed|||29430821|||Chembiochem. 2018 May 4;19(9):931-940.|||Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed 12 FPDB04393 AP04639|||CAMPSQ18580|||Retro-KR-12|||AP04639 RLFDKIRQVIRK Anti-E. coli, activity value is MIC = 5 uM||Anti-P. aeruginosa, activity value is MIC = 10 uM||Anti-S. aureus, activity value is MIC = 10 uM||Anti-and C. albicans, activity value is MIC = 5 uM||Antibacterial||Antifungal Amino acid reversal, sequence shuffling, designed|||Synthetic construct|||Synthetic construct|||Amino acid reversal, sequence shuffling, designed Helix N/A Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed|||29430821|||32153522|||Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed 12 FPDB04394 AP04640|||A-KR12-GA-KR12-G|||A-KR12-GA-KR12-G|||AP04640 AKRIVQRIKDFLRGAKRIVQRIKDFLRG Anti-E. coli, activity value is MIC = 5 uM||Anti-P. aeruginosa, activity value is MIC = 10 uM||Anti-S. aureus, activity value is MIC = 10 uM||Anti-and C. albicans, activity value is MIC = 5 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 0.625 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 0.625 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 1.25 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 1.25 uM designed|||Synthetic construct|||Synthetic construct|||designed N/A N/A Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed|||32153522|||32153522|||Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed 28 FPDB04395 AP04641|||AG-KR12-GAG-KR12-G AGKRIVQRIKDFLRGAGKRIVQRIKDFLRG Anti-E. coli, activity value is MIC = 5 uM||Anti-P. aeruginosa, activity value is MIC = 10 uM||Anti-S. aureus, activity value is MIC = 10 uM||Anti-and C. albicans, activity value is MIC = 5 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 0.625 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 0.625 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 1.25 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 1.25 uM designed, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct N/A N/A Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed|||32153522|||Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed 30 FPDB04396 AP04642|||AGG-KR12-GAGG-KR12-G|||AGG-KR12-GAGG-KR12-G|||DRAMP35717|||AP04642 AGGKRIVQRIKDFLRGAGGKRIVQRIKDFLRG Anti-E. coli, activity value is MIC = 5 uM||Anti-P. aeruginosa, activity value is MIC = 10 uM||Anti-S. aureus, activity value is MIC = 10 uM||Anti-and C. albicans, activity value is MIC = 5 uM||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 0.625 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 0.625 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 1.25 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 2.5 uM||Anti-Human histiocytic lymphoma U-937/GTB, activity value is IC50 = 5.1 uM||Antimicrobial||Anticancer designed, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||Synthetic|||designed, human cathelicidin analog, animal-derived, natural derivative Helix human RBC, HC50 >40 uM.|||Human erythrocytes (50% Hemolysis at >40 uM|||Human erythrocytes (50% Hemolysis at >40 uM|||human RBC, HC50 >40 uM. Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed|||32153522|||32153522|||Front Microbiol. 2020 Feb 21;11:168.|||Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed 32 FPDB04397 AP04643|||AGG-KR12-GAGG-KR12-G|||AGG-KR12-GAGG-KR12-G|||DRAMP35718|||AP04643 AGGKRIVKRIKKFLRGAGGKRIVKRIKKFLRG Anti-E. coli, activity value is MIC = 0.625 uM||Anti-P. aeruginosa, activity value is MIC = 0.625 uM||Anti-S. aureus, activity value is MIC = 0.625 uM||Anti-and C. albicans, activity value is MIC = 1.25 uM||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 0.625 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 0.625 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 0.625 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 1.25 uM||Anti-Human histiocytic lymphoma U-937/GTB, activity value is IC50 = 1 uM||Antimicrobial||Anticancer amino acid substitution, designed|||Synthetic construct|||Synthetic construct|||Synthetic|||amino acid substitution, designed Helix human RBC, HC50 10 uM, hemolytic.|||Human erythrocytes (50% Hemolysis at 10 uM|||Human erythrocytes (50% Hemolysis at 10 uM|||human RBC, HC50 10 uM, hemolytic. Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed|||32153522|||32153522|||Front Microbiol. 2020 Feb 21;11:169.|||Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed 32 FPDB04398 AP04644|||AGG-KR12-GAGG-retroKR12-G|||AGG-KR12-GAGG-retroKR12-G|||AP04644 AGGKRIVQRIKDFLRGAGGRLFDKIRQVIRKG Anti-E. coli, activity value is MIC = 1.25 uM||Anti-P. aeruginosa, activity value is MIC = 0.625 uM||Anti-S. aureus, activity value is MIC = 1.25 uM||Anti-and C. albicans, activity value is MIC = 2.5 uM||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1.25 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 0.625 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 1.25 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 2.5 uM designed, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||designed, human cathelicidin analog, animal-derived, natural derivative N/A N/A Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed|||32153522|||32153522|||Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed 32 FPDB04399 AP04645 AGGRLFDKIRQVIRKGAGGRLFDKIRQVIRKG Anti-E. coli, activity value is MIC = 0.625 uM||Anti-P. aeruginosa, activity value is MIC = 1.25 uM||Anti-S. aureus, activity value is MIC = 1.25 uM||Anti-and C. albicans, activity value is MIC = 2.5 uM designed, human cathelicidin analog, animal-derived, natural derivative Helix N/A Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed|||Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed 32 FPDB04400 AP04646|||AG-KR12-GAG-retroKR12-G|||AG-KR12-GAG-retroKR12-G|||AP04646 AGKRIVQRIKDFLRGAGRLFDKIRQVIRKG Anti-E. coli, activity value is MIC = 1.25 uM||Anti-P. aeruginosa, activity value is MIC = 1.25 uM||Anti-S. aureus, activity value is MIC = 1.25 uM||Anti-and C. albicans, activity value is MIC = 2.5 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1.25 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1.25 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 1.25 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 2.5 uM designed, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||designed, human cathelicidin analog, animal-derived, natural derivative N/A N/A Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed|||32153522|||32153522|||Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed 30 FPDB04401 AP04647|||A-KR12-GA-retroKR12-G|||A-KR12-GA-retroKR12-G|||AP04647 AKRIVQRIKDFLRGARLFDKIRQVIRKG Anti-E. coli, activity value is MIC = 0.625 uM||Anti-P. aeruginosa, activity value is MIC = 1.25 uM||Anti-S. aureus, activity value is MIC = 1.25 uM||Anti-and C. albicans, activity value is MIC = 2.5 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 0.625 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1.25 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 1.25 uM||Anti-Candida albicans ATCC 90028, activity value is MIC = 2.5 uM designed, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct|||designed, human cathelicidin analog, animal-derived, natural derivative N/A N/A Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed|||32153522|||32153522|||Front Microbiol. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168. PubMed 28 FPDB04431 AP04687|||DRAMP18623 INLKILARLAKKIL Anti-Gram- E. coli ATCC 25922, activity value is MIC = 12.5 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 6.25 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 6.25 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 3 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 25 uM||Anti-S. pyogenes ATCC 19615, activity value is MIC = 6.25 uM||Anti-L. ivanovii Li 4pVS2, activity value is MIC = 50 uM||Anti-E.faecalis ATCC 29212, activity value is MIC > 100 uM||Anti-C. albicans ATCC 90028, activity value is MIC = 12.5 uM||Anti-and C. parapsilosis ATCC 22019, activity value is MIC = 25 uM||Antibacterial||Antifungal||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 25 uM||Anti-Streptococcus pyogenes ATCC 19615, activity value is MIC = 6.25 uM||Anti-Listeria ivanovii Li 4pVS2, activity value is MIC = 50 uM||Anti-##Gram-negative bacteria: Escherichia coli ATCC 25922, activity value is MIC = 12.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 6.25 uM||Anti-Klebsiella pneumoniae ATCC 13883, activity value is MIC = 6.25 uM||Anti-Acinetobacter baumannii ATCC 19606, activity value is MIC = 3 uM||Anti-##Fungi: Candida albicans ATCC 90028, activity value is MIC = 12.5 uM||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 25 uM||Anti-Gram+ & Gram-||Antiviral||candidacidal designed, amino acid substitution, animal-derived, natural derivative|||Synthetic construct Alpha helix "rat RBC: HC50 > 200 uM, poor hemo.lytic. THP-1-derived macrophages (IC50 24..5 uM0, and HEK-293 (IC50 > 200 uM).|||Rat red blood cells (LC50 =>200 uM, )|||[Ref.27423268]LC50>200 uM against rat red blood cells|||The document mentions hemolytic data related to mastoparan L and [I^{5}, R^{8}] mastoparan, as follows: - Mastoparan L: In rat red blood cells, a concentration of 10 µM can cause 40% hemolysis (note e in Table 2). - [I^{5}, R^{8}] mastoparan: The 50% hemolytic concentration (LC_{50}) for human red blood cells is greater than 200 µM, indicating no significant hemolytic activity within the tested concentration range (Table 2). In the hemolysis assay, the group treated with 1% Triton X-100 was used as the 100% hemolysis positive control, and hemoglobin release was evaluated by measuring absorbance at 540 nm.|||rat RBC: HC50 > 200 uM, poor hemo.lytic." Biochim Biophys Acta. 2016 Nov;1858(11):2699-2708. doi: 10.1016/j.bbamem.2016.07.001. PubMed|||27423268|||Biochim Biophys Acta. 2016 Nov;1858(11):2699-2708.||Ref.27423268|||Biochim Biophys Acta. 2016 Nov;1858(11):2699-2708. doi: 10.1016/j.bbamem.2016.07.001. PubMed 14 FPDB04432 AP04688|||Eumenitin-R|||DRAMP03038|||Eumenitin-R|||AP04688 LNLKGLIKKVASLLN Anti-Gram+ S. aureus ATCC 25923, activity value is MIC = 60 uM||Anti-S. epidermidis clinical sample, activity value is MIC = 30 uM||Anti-M. luteus ATCC 10240, activity value is MIC = 15 uM||Anti-S. pyogenes clinical sample, activity value is MIC = 15 uM||Anti-B. subtilis ATCC 6633, activity value is MIC = 7.5 uM||Anti-E. coli ATCC 25922, activity value is MIC = 30 uM||Anti-P. mirabilis clinical sample, activity value is MIC = 60 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 30 uM||Anti-S. maltophilia ATCC 13637, activity value is MIC = 15 uM||Anti-C. albicans ATCC 90112, activity value is MIC < 7.5 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 60 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 30 uM||Anti-Micrococcus luteus ATCC 10240, activity value is MIC = 15 uM||Anti-Streptococcus pyogenes, activity value is MIC = 15 uM||Anti-Bacillus subtilis ATCC, activity value is MIC = 7.5 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30 uM||Anti-Proteus mirabilis, activity value is MIC = 60 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 30 uM||Anti-Stenotrophomonas maltophilia ATCC 13637, activity value is MIC = 15 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 3 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 1.5 ug/ml||Antibacterial||Antifungal Venom, solitary eumenine wasp, Eumenes rubrofemoratus|||Eumenes rubrofemoratus|||Eumenes rubrofemoratus (Solitary wasp)|||Eumenes rubrofemoratus [Solitary wasp]|||Venom, solitary eumenine wasp, Eumenes rubrofemoratus, Asia Helix The four peptides (eumenitin-R, eumenitin-F, EMP-ER, EMP-EF) have very low hemolytic activity against mouse red blood cells. The specific hemolytic values are as follows: the half-maximal hemolysis concentration (EC₅₀) of eumenitin-R is 530.3 μM, with a 95% confidence interval of 512.9-548.3 μM; the EC₅₀ of EMP-ER is 200 μM, with a 95% confidence interval of 189.6-211 μM; the EC₅₀ of eumenitin-F is 353.4 μM, with a 95% confidence interval of 251.7-496.3 μM; and the EC₅₀ of EMP-EF is 181.1 μM, with a 95% confidence interval of 142.6-229.9 μM. Toxicon. 2011 Jun;57(7-8):1081-92. doi: 10.1016/j.toxicon.2011.04.014. PubMed|||21549739|||Toxicon. 2011 Jun;57(7-8):1081-1092.|||21549739|||Toxicon. 2011 Jun;57(7-8):1081-92. doi: 10.1016/j.toxicon.2011.04.014. PubMed 15 FPDB04433 AP04689|||CAMPSQ4582|||DRAMP03041|||Eumenine mastoparan-ER|||AP04689 FDIMGLIKKVAGAL Anti-Gram+ S. aureus ATCC 25923, activity value is MIC = 30 uM||Anti-S. epidermidis clinical sample, activity value is MIC = 30 uM||Anti-M-luteus ATCC 10240, activity value is MIC > 30 uM||Anti-S-pyogenes clinical sample, activity value is MIC > 30 uM||Anti-B. subtilis ATCC 6633, activity value is MIC = 30 uM||Anti-E. coli ATCC 25922, activity value is MIC = 30 uM||Anti-P. mirabilis clinical sample, activity value is MIC = 60 uM||Anti-P-aeruginosa ATCC 27853, activity value is MIC > 30 uM||Anti-S-maltophilia ATCC 13637, activity value is MIC > 30 uM||Anti-C. albicans ATCC 90112, activity value is MIC = 7.5 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 30 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 30 uM||Anti-Micrococcus luteus ATCC 10240, activity value is MIC > 30 uM||Anti-Streptococcus pyogenes, activity value is MIC > 30 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 30 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30 uM||Anti-Proteus mirabilis, activity value is MIC = 60 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 30 uM||Anti-Stenotrophomonas maltophilia ATCC 13637, activity value is MIC > 30 uM||Anti-Candida albicans ATCC 90112, activity value is MIC = 7.5 uM||Antibacterial||Antifungal Venom, solitary eumenine wasp, Eumenes rubrofemoratus|||Eumenes rubrofemoratus [Solitary wasp]|||Eumenes rubrofemoratus (Solitary wasp)|||Eumenes rubrofemoratus [Solitary wasp]|||Venom, solitary eumenine wasp, Eumenes rubrofemoratus, Asia Helix rat RBC: HC50 > 230.6 uM. Less hemo.lytic.|||The four peptides (eumenitin-R, eumenitin-F, EMP-ER, EMP-EF) have very low hemolytic activity against mouse red blood cells. The specific hemolytic values are as follows: the half-maximal hemolysis concentration (EC₅₀) of eumenitin-R is 530.3 μM, with a 95% confidence interval of 512.9-548.3 μM; the EC₅₀ of EMP-ER is 200 μM, with a 95% confidence interval of 189.6-211 μM; the EC₅₀ of eumenitin-F is 353.4 μM, with a 95% confidence interval of 251.7-496.3 μM; and the EC₅₀ of EMP-EF is 181.1 μM, with a 95% confidence interval of 142.6-229.9 μM. Toxicon. 2011 Jun;57(7-8):1081-92. doi: 10.1016/j.toxicon.2011.04.014. PubMed|||21549739|||Toxicon. 2011 Jun;57(7-8):1081-1092.||Ref.21549739|||21549739|||Toxicon. 2011 Jun;57(7-8):1081-92. doi: 10.1016/j.toxicon.2011.04.014. PubMed 14 FPDB04434 AP04690|||Eumenitin-F|||DRAMP03039|||Eumenitin-F|||AP04690 LNLKGLFKKVASLLT Anti-Gram+ S-aureus ATCC 25923, activity value is MIC > 60 uM||Anti-S. epidermidis clinical sample, activity value is MIC = 30 uM||Anti-M. luteus ATCC 10240, activity value is MIC = 30 uM||Anti-S. pyogenes clinical sample, activity value is MIC = 30 uM||Anti-B. subtilis ATCC 6633, activity value is MIC = 30 uM||Anti-E. coli ATCC 25922, activity value is MIC = 30 uM||Anti-P-mirabilis clinical sample, activity value is MIC > 60 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 30 uM||Anti-S. maltophilia ATCC 13637, activity value is MIC = 15 uM||Anti-C. albicans ATCC 90112, activity value is MIC = 7.5 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 60 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 30 uM||Anti-Micrococcus luteus ATCC 10240, activity value is MIC = 30 uM||Anti-Streptococcus pyogenes, activity value is MIC = 30 uM||Anti-Bacillus subtilis ATCC, activity value is MIC = 30 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30 uM||Anti-Proteus mirabilis, activity value is MIC > 60 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 30 uM||Anti-Stenotrophomonas maltophilia ATCC 13637, activity value is MIC = 15 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 30 uM||Anti-Candida albicans ATCC 90112, activity value is MIC = 7.5 uM||Antibacterial||Antifungal Venom, solitary eumenine wasp, Eumenes fraterculus|||Eumenes rubrofemoratus|||Eumenes rubrofemoratus (Solitary wasp)|||Eumenes rubrofemoratus [Solitary wasp]|||Venom, solitary eumenine wasp, Eumenes fraterculus, North America Helix human RBC: HC50 157.1 uM; rat RBC: HC50 207.1 uM. Less hemo.lytic.|||The four peptides (eumenitin-R, eumenitin-F, EMP-ER, EMP-EF) have very low hemolytic activity against mouse red blood cells. The specific hemolytic values are as follows: the half-maximal hemolysis concentration (EC₅₀) of eumenitin-R is 530.3 μM, with a 95% confidence interval of 512.9-548.3 μM; the EC₅₀ of EMP-ER is 200 μM, with a 95% confidence interval of 189.6-211 μM; the EC₅₀ of eumenitin-F is 353.4 μM, with a 95% confidence interval of 251.7-496.3 μM; and the EC₅₀ of EMP-EF is 181.1 μM, with a 95% confidence interval of 142.6-229.9 μM. Toxicon. 2011 Jun;57(7-8):1081-92. doi: 10.1016/j.toxicon.2011.04.014. PubMed|||21549739|||Toxicon. 2011 Jun;57(7-8):1081-1092.||Ref.21549739|||21549739|||Toxicon. 2011 Jun;57(7-8):1081-92. doi: 10.1016/j.toxicon.2011.04.014. PubMed 15 FPDB04435 AP04691|||CAMPSQ4581|||DRAMP03040|||Eumenine mastoparan-EF|||AP04691 FDVMGIIKKIAGAL Anti-Gram+ S. aureus ATCC 25923, activity value is MIC = 30 uM||Anti-S. epidermidis clinical sample, activity value is MIC = 30 uM||Anti-M. luteus ATCC 10240, activity value is MIC = 30 uM||Anti-S-pyogenes clinical sample, activity value is MIC > 30 uM||Anti-B. subtilis ATCC 6633, activity value is MIC = 30 uM||Anti-E. coli ATCC 25922, activity value is MIC = 30 uM||Anti-P. mirabilis clinical sample, activity value is MIC = 60 uM||Anti-P-aeruginosa ATCC 27853, activity value is MIC > 30 uM||Anti-S-maltophilia ATCC 13637, activity value is MIC > 30 uM||Anti-C. albicans ATCC 90112, activity value is MIC = 7.5 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 30 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 30 uM||Anti-Micrococcus luteus ATCC 10240, activity value is MIC = 30 uM||Anti-Streptococcus pyogenes, activity value is MIC > 30 uM||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 30 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30 uM||Anti-Proteus mirabilis, activity value is MIC = 60 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 30 uM||Anti-Stenotrophomonas maltophilia ATCC 13637, activity value is MIC > 30 uM||Anti-Candida albicans ATCC 90112, activity value is MIC = 7.5 uM||Antibacterial||Antifungal Venom, solitary eumenine wasp, Eumenes fraterculus|||Eumenes fraterculus [Solitary wasp]|||Eumenes rubrofemoratus (Solitary wasp)|||Eumenes fraterculus [Solitary wasp]|||Venom, solitary eumenine wasp, Eumenes fraterculus, North America Helix The four peptides (eumenitin-R, eumenitin-F, EMP-ER, EMP-EF) have very low hemolytic activity against mouse red blood cells. The specific hemolytic values are as follows: the half-maximal hemolysis concentration (EC₅₀) of eumenitin-R is 530.3 μM, with a 95% confidence interval of 512.9-548.3 μM; the EC₅₀ of EMP-ER is 200 μM, with a 95% confidence interval of 189.6-211 μM; the EC₅₀ of eumenitin-F is 353.4 μM, with a 95% confidence interval of 251.7-496.3 μM; and the EC₅₀ of EMP-EF is 181.1 μM, with a 95% confidence interval of 142.6-229.9 μM. Toxicon. 2011 Jun;57(7-8):1081-92. doi: 10.1016/j.toxicon.2011.04.014. PubMed|||21549739|||Toxicon. 2011 Jun;57(7-8):1081-1092.||Ref.21549739|||21549739|||Toxicon. 2011 Jun;57(7-8):1081-92. doi: 10.1016/j.toxicon.2011.04.014. PubMed 14 FPDB04436 AP04692|||EpVP1, VP1 protein|||EpVP1, VP1 protein|||AP04692 INLKGLIKKVASLLT Anti-E. coli, activity value is MIC = 25 uM||Anti-S. aureus, activity value is MIC = 100 uM||Anti-C. albicans, activity value is MIC = 100 uM||Anti-and B. cinerea, activity value is MIC = 5 uM||Anti-Escherichia coli ATCC 11775, activity value is MIC = 25 uM||Anti-Staphylococcus aureus ATCC 12600, activity value is MIC = 100 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 100 uM||Anti-Botrytis cinerea, activity value is MIC = 5 uM||Antibacterial||Antifungal||Mammalian Cell Venom, wasp, Eumenes pomiformis|||Eumenes pomiformis|||Eumenes pomiformis|||Venom, wasp, Eumenes pomiformis, Europe, Asia, Africa N/A No effect on human erythrocytes Toxicon. 2010 Jun 1;55(6):1147-56. doi: 10.1016/j.toxicon.2010.01.004. PubMed|||21184791|||21184791|||Toxicon. 2010 Jun 1;55(6):1147-56. doi: 10.1016/j.toxicon.2010.01.004. PubMed 15 FPDB04437 AP04693|||CAMPSQ16804|||EpVP2a, VP2a protein|||AP04693 FDLLGLVKKVASAL Anti-E. coli, activity value is MIC = 100 uM||Anti-S. aureus, activity value is MIC = 50 uM||Anti-C. albicans, activity value is MIC = 100 uM||Anti-and B. cinerea, activity value is MIC = 5 uM||Anti-Escherichia coli ATCC 11775, activity value is MIC = 100 uM||Anti-Staphylococcus aureus ATCC 12600, activity value is MIC = 50 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 100 uM||Anti-Botrytis cinerea, activity value is MIC = 5 uM||Antibacterial||Antifungal||Mammalian Cell Venom, wasp, Eumenes pomiformis|||Eumenes pomiformis|||Eumenes pomiformis|||Venom, wasp, Eumenes pomiformis, Europe, Asia, Africa N/A human RBC: HC50 151.9 uM; rat RBC: HC50 238.8 uM. Less hemo.lytic.|||No effect on human erythrocytes|||No effect on human erythrocytes|||human RBC: HC50 151.9 uM; rat RBC: HC50 238.8 uM. Less hemo.lytic. Toxicon. 2010 Jun 1;55(6):1147-56. doi: 10.1016/j.toxicon.2010.01.004. PubMed|||21184791|||21184791|||Toxicon. 2010 Jun 1;55(6):1147-56. doi: 10.1016/j.toxicon.2010.01.004. PubMed 14 FPDB04438 AP04694|||CAMPSQ16805|||EpVP2b, VP2b protein|||AP04694 FDLLGLVKSVVSAL Anti-E.coli, activity value is MIC = 200 uM||Anti-S. aureus, activity value is MIC = 25 uM||Anti-C. albicans, activity value is MIC = 100 uM||Anti-and B. cinerea, activity value is MIC = 5 uM||Anti-Escherichia coli ATCC 11775, activity value is MIC = 200 uM||Anti-Staphylococcus aureus ATCC 12600, activity value is MIC = 25 uM||Anti-Candida albicans ATCC 10231, activity value is MIC = 100 uM||Anti-Botrytis cinerea, activity value is MIC = 5 uM||Antibacterial||Antifungal||Mammalian Cell Venom, wasp, Eumenes pomiformis|||Eumenes pomiformis|||Eumenes pomiformis|||Venom, wasp, Eumenes pomiformis, Europe, Asia, Africa N/A human RBC: HC50 34.1 uM; rat RBC: HC50 50.6 uM. hemolytic.|||Human erythrocytes (EC50 = 64 uM)|||Human erythrocytes (EC50 = 64 uM)|||human RBC: HC50 34.1 uM; rat RBC: HC50 50.6 uM. hemolytic. Toxicon. 2010 Jun 1;55(6):1147-56. doi: 10.1016/j.toxicon.2010.01.004. PubMed|||21184791|||21184791|||Toxicon. 2010 Jun 1;55(6):1147-56. doi: 10.1016/j.toxicon.2010.01.004. PubMed 14 FPDB04439 AP04695|||EpVP6, VP6 protein|||EpVP6, VP6 protein|||AP04695 FGPVIGLLSGILKSLL Anti-E.coli, activity value is MIC > 200 uM||Anti-S. aureus, activity value is MIC = 50 uM||Anti-C.albicans, activity value is MIC > 200 uM||Anti-and B. cinerea, activity value is MIC = 5 uM||Anti-Escherichia coli ATCC 11775, activity value is MIC > 200 uM||Anti-Staphylococcus aureus ATCC 12600, activity value is MIC = 50 uM||Anti-Candida albicans ATCC 10231, activity value is MIC > 200 uM||Anti-Botrytis cinerea, activity value is MIC = 5 uM Venom, wasp, Eumenes pomiformis|||Eumenes pomiformis|||Venom, wasp, Eumenes pomiformis, Europe, Asia, Africa N/A No effect on human erythrocytes Toxicon. 2010 Jun 1;55(6):1147-56. doi: 10.1016/j.toxicon.2010.01.004. PubMed|||21184791|||21184791|||Toxicon. 2010 Jun 1;55(6):1147-56. doi: 10.1016/j.toxicon.2010.01.004. PubMed 16 FPDB04502 AP04765 GFLDVIKHVGKAALSVVSHLINE Anti-E. coli, activity value is MIC = 13.09 uM||Anti-S. aureus, activity value is MIC = 26.18 uM||Anti-and C. albicans, activity value is MIC = 52.36 uM||Anti-P. falciparum NF54, activity value is IC50 = 13.86 uM||Anti-L. Mexicana, activity value is IC50 = 0.09 uM the splendid leaf frog, Cruziohyla calcarifer, Central and South America|||the splendid leaf frog, Cruziohyla calcarifer, Central and South America N/A In vitro toxicity: 4% RBC: hemolysis of 13% at 128 uM (HC50>100 uM), low hemo.lytic.|||4% RBC: hemolysis of 13% at 128 uM (HC50>100 uM), low hemo.lytic. Microbiol Spectr. 2024 Jul 16:e0333923. doi: 10.1128/spectrum.03339-23. PubMed|||Microbiol Spectr. 2024 Jul 16:e0333923. doi: 10.1128/spectrum.03339-23. PubMed 23 FPDB04527 AP04795|||CAMPSQ12378|||AP04795 KRRWPWWPWRLI Anti-Gram+ E. faecalis PCM 2673, activity value is MIC = 16 ug/ml||Anti-S. aureus ATCC 25923 or 9144, activity value is MIC = 8 ug/ml||Anti-S. pneumoniae ATCC 49619, activity value is MIC = 8 ug/ml||Anti-E. coli ATCC 25922 or 23506, activity value is MIC = 4||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 4 ug/ml||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 4 ug/ml||Anti-A. niger ATCC 16404, activity value is MIC = 64 ug/ml||Anti-C.albicans ATCC 10231, activity value is MIC = 32 ug/ml||Anti-and C. glabrata ATCC 15126, activity value is MIC = 64 ug/ml||Antibacterial sequence reversal, sequence shuffling, designed, man-made sequences|||Synthetic construct|||sequence reversal, sequence shuffling, designed, man-made sequences Rich 4% human RBC: >10% hemolysis at 512 ug/ml. Amino Acids. 2017 Oct;49(10):1755-1771. doi: 10.1007/s00726-017-2473-7. PubMed|||30043322|||Amino Acids. 2017 Oct;49(10):1755-1771. doi: 10.1007/s00726-017-2473-7. PubMed 12 FPDB04543 AP04826|||Cancrin|||Cancrin|||DRAMP04616|||AP04826 GSAQPYKQLHKVVNWDPYG Anti-E.coli ATCC25922, activity value is MIC > 100 ug/ml||Anti-B. dysenteriae, activity value is MIC = 60 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 15 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 30 ug/ml||Antibacterial||Antifungal ; Synthetic construct||Antifungal||Antifungal ; E. coli ATCC25922||B. dysenteriae||S. aureus ATCC2592||C. albicans ATCC2002||No MICs found in DRAMP database The crab-eating frog, Rana cancrivora or Fejervarya cancrivora, Asia|||Synthetic construct|||Fejervarya cancrivora|||The crab-eating frog, Rana cancrivora or Fejervarya cancrivora, Asia N/A rabbit RBC: little hemolysis up to 100 ug/ml.|||Low hemolytic activity against Rabbit RBC|||Low hemolytic activity against Rabbit RBC|||No hemolysis information or data found in the reference(s) presented in this entry|||rabbit RBC: little hemolysis up to 100 ug/ml. Mol Immunol. 2008 Feb;45(3):678-81. doi: 10.1016/j.molimm.2007.07.004. PubMed|||https://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ16571#:~:text=PubMed%20%3A-,17707909,-Activity%20%3A|||17707909|||Mol Immunol. 2008 Feb;45(3):678-681.|||Mol Immunol. 2008 Feb;45(3):678-81. doi: 10.1016/j.molimm.2007.07.004. PubMed 19 FPDB04548 AP04841 RKCNLFCKAKQKLKSLSSVIGTVVHPPRG Anti-A.baumannii, activity value is MIC > 100 ug/ml||Anti-P. maltophilia, activity value is MIC = 75 ug/ml||Anti-S. aureus, activity value is MIC = 37.5 ug/ml||Anti-B. cereus, activity value is MIC = 37.5 ug/ml||Anti-B. subtilis, activity value is MIC = 37.5 ug/ml||Anti-C. albicans, activity value is MIC = 37.5 ug/ml||Anti-C. glabrata, activity value is MIC = 37.5 ug/ml Paa robertingeri or Quasipaa robertingeri, China, Asia|||Paa robertingeri or Quasipaa robertingeri, China, Asia N/A N/A Annual Research & Review in Biology 2019; 32: 1-10. Publisher|||Annual Research & Review in Biology 2019; 32: 1-10. Publisher 29 FPDB04555 AP04848 WWKKWWKKWWK Anti-Gram+ S. aureus ATCC 25923A, activity value is MIC = 25 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 3.12 uM||Anti-B. megaterium Bm 11, activity value is MIC = 0.75 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 50 uM||Anti-P. aeruginosa, activity value is MIC = 3.12 uM||Anti-E. coli ATCC 25922, activity value is MIC = 6.25 uM||Anti-P. aeruginosa ATCC 27853 or 19595 or 4 clinical strains, activity value is MIC = 1.56||Anti-and yeast C. albicans ATCC 24433, activity value is MIC = 6.25 uM de novo designed Rich showed minimal toxicity to HaCaT cells (20% viability decrease at 25 uM and 25% decrease at 50 uM). Front Chem. 2022 Nov 17;10:1000765. doi: 10.3389/fchem.2022.1000765. PubMed|||Front Chem. 2022 Nov 17;10:1000765. doi: 10.3389/fchem.2022.1000765. PubMed 11 FPDB04588 AP04900|||Cecropin B|||Cecropin B|||AP04900 RWKIFKKIEKMGGSYCNRRTGKCQRM Anti-B. subtilis, activity value is MIC = 10 uM||Anti-K. pneumoniae, activity value is MIC = 80 uM||Anti-E. coli JM109, activity value is MIC = 20||Anti-S. cerevisiae, activity value is MIC = 20||Anti-and C. albicans, activity value is MIC = 50 uM||Anti-Bacillus subtilis, activity value is MIC = 10 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 80 uM||Anti-Escherichia coli JM109, activity value is MIC = 20||Anti-Saccharomyces cerevisiae, activity value is MIC = 20||Anti-Candida albicans, activity value is MIC = 50 uM designed, peptide hybrid|||Synthetic construct|||Synthetic construct|||designed, peptide hybrid N/A N/A J Pept Res. 2005 Dec;66(6):382-6. doi: 10.1111/j.1399-3011.2005.00299.x. PubMed|||16316454|||16316454|||J Pept Res. 2005 Dec;66(6):382-6. doi: 10.1111/j.1399-3011.2005.00299.x. PubMed 26 FPDB04617 AP04931 VVGACRRALCLPRERRAGFCRIRGRIHPLCGRR Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-E. coli, activity value is MIC = 1.6 ug/ml||Anti-S. typhimurium, activity value is MIC = 4.3 ug/ml||Anti-P. aeruginosa, activity value is MIC = 4.8 ug/ml||Anti-K. pneumoniae, activity value is MIC = 5.3 ug/ml||Anti-L. monocytogenes, activity value is MIC = 1.7 ug/ml||Anti-and C. albicans, activity value is MIC = 19 ug/ml circularization, amino acid SUBSTITUTION, defensin analog, animal-derived, natural derivatives N/A human RBC, not hemo.lytic (HC50 1830 ug/ml). J Biol Chem. 2000 Feb 11;275(6):3943-9. doi: 10.1074/jbc.275.6.3943. PubMed|||J Biol Chem. 2000 Feb 11;275(6):3943-9. doi: 10.1074/jbc.275.6.3943. PubMed 33 FPDB04618 AP04932 VVGACRRALGLPRERRAGFCRIRGRIHPLGGRR Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-E. coli, activity value is MIC = 1.6 ug/ml||Anti-S. typhimurium, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa, activity value is MIC = 2.5 ug/ml||Anti-K. pneumoniae, activity value is MIC = 2.5 ug/ml||Anti-L. monocytogenes, activity value is MIC = 1.8 ug/ml||Anti-and C. albicans, activity value is MIC = 19.9 ug/ml circularization, amino acid SUBSTITUTION, defensin analog, animal-derived, natural derivatives N/A human RBC, not hemo.lytic (HC50 3188 ug/ml). J Biol Chem. 2000 Feb 11;275(6):3943-9. doi: 10.1074/jbc.275.6.3943. PubMed|||J Biol Chem. 2000 Feb 11;275(6):3943-9. doi: 10.1074/jbc.275.6.3943. PubMed 33 FPDB04619 AP04933 VVGAGRRALCLPRERRAGFGRIRGRIHPLCGRR Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-E. coli, activity value is MIC = 1.6 ug/ml||Anti-S. typhimurium, activity value is MIC = 2.5 ug/ml||Anti-P. aeruginosa, activity value is MIC = 2.3 ug/ml||Anti-K. pneumoniae, activity value is MIC = 5.8 ug/ml||Anti-L. monocytogenes, activity value is MIC = 1.9 ug/ml||Anti-and C. albicans, activity value is MIC = 21.7 ug/ml circularization, amino acid SUBSTITUTION, defensin analog, animal-derived, natural derivatives N/A human RBC, not hemo.lytic (HC50 4791 ug/ml). J Biol Chem. 2000 Feb 11;275(6):3943-9. doi: 10.1074/jbc.275.6.3943. PubMed|||J Biol Chem. 2000 Feb 11;275(6):3943-9. doi: 10.1074/jbc.275.6.3943. PubMed 33 FPDB04789 AP05139|||CAMPSQ9482|||CAMPSQ12486|||AP05139 FKCRRWQWRMKKLG Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-E. coli ATCC 25922, activity value is MIC = 200 uM||activity value is MBC = 200 uM||Anti-Gram- E. coli O157:H7 or K12, activity value is MIC = 1.8||Anti-P. aeruginosa Pak, activity value is MIC = 1.5 uM||Anti-A. naeslundii, activity value is MIC = 10 uM||Anti-P.gingivalis HG 66, activity value is MIC > 100 uM||Anti-B. subtilis ATCC 9372, activity value is MIC = 10 uM||Anti-S. sanguis SK4, activity value is MIC = 5.5 uM||Anti-S. mutans, activity value is MIC = 5.5 uM||Anti-and yeast C. albicans ATCC 10231, activity value is MIC = 1.5 uM sequence truncation, lactoferrin fragment, animal-derived, natural derivatives|||Synthetic construct|||Bos taurus [Bovine]|||sequence truncation, lactoferrin fragment, animal-derived, natural derivatives N/A human RBC: only hemolytic at high concentration close to 100 uM. Peptides. 2004 Feb;25(2):177-83. doi: 10.1016/j.peptides.2003.12.006. PubMed|||28613262|||28875176|||Peptides. 2004 Feb;25(2):177-83. doi: 10.1016/j.peptides.2003.12.006. PubMed 14 FPDB04790 AP05140|||WR17|||WR17|||AP05140 WKLLSKAQEKFGKNKSR Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-Pseudomonas aeruginosa, activity value is MIC = 9.5 uM||Anti-Candida albicans SC5314, activity value is MIC = 25 uM||Anti-Gram- E. coli O157:H7 or K12, activity value is MIC = 5.8||Anti-P. aeruginosa Pak, activity value is MIC = 7 uM||Anti-A.naeslundii, activity value is MIC > 100 uM||Anti-P.gingivalis HG 66, activity value is MIC > 100 uM||Anti-B. subtilis ATCC 9372, activity value is MIC = 18 uM||Anti-S.sanguis SK4, activity value is MIC > 100 uM||Anti-S.mutans, activity value is MIC > 100 uM||Anti-and yeast C. albicans ATCC 10231, activity value is MIC = 2.1 uM lactoferrin fragment|||Bac5Synthetic construct|||lactoferrin fragment Helix human RBC: only hemolytic at high concentration close to 100 uM. Peptides. 2004 Feb;25(2):177-83. doi: 10.1016/j.peptides.2003.12.006. PubMed|||30658284|||30658284|||Peptides. 2004 Feb;25(2):177-83. doi: 10.1016/j.peptides.2003.12.006. PubMed 17 FPDB04791 AP05141|||LFampin 259-284|||LFampin 259-284|||AP05141 SVDGKEDLIWKLLSKAQEKFGKNKSR Anti-Gram-||Antifungal||candidacidal||Candida albicans ATCC 10231[LC50 = 2.3+-0.2 uM]||Escherichia coli K-12[LC50 = 11.7+-0.5 uM]||Antibacterial||Active against Gram- E. coli K12 (LC50 11.7 uM)||and yeast C. albicans ATCC 10231 (LC50 2.3 uM). Warning: other bacteria not tested. lactoferrin fragment|||Synthetic construct|||Synthetic construct|||lactoferrin fragment N/A N/A Peptides. 2006 Jan;27(1):1-9. doi: 10.1016/j.peptides.2005.06.012. PubMed|||16087276|||16087276|||Peptides. 2006 Jan;27(1):1-9. doi: 10.1016/j.peptides.2005.06.012. PubMed 26 FPDB04792 AP05142|||LFampin 265-296 DLIWKLLSKAQEKFGKNKSRSFQLFGSPPGQR Anti-Gram-||Antifungal||candidacidal||Antibacterial||Active against Gram- E. coli K12 (LC50 2.5 uM)||and yeast C. albicans ATCC 10231 (LC50 0.5 uM). LC50: 50% reduction in viable counts. Warning: other bacteria not tested. lactoferrin fragment|||Synthetic construct N/A N/A Peptides. 2006 Jan;27(1):1-9. doi: 10.1016/j.peptides.2005.06.012. PubMed|||16087276|||Peptides. 2006 Jan;27(1):1-9. doi: 10.1016/j.peptides.2005.06.012. PubMed 32 FPDB04793 AP05143|||LFampin 265-284 DLIWKLLSKAQEKFGKNKSR Anti-Gram-||Antifungal||candidacidal||Antifungal ; C.albicans(LC50= 0.8 uM)||Active against Gram- E. coli K12 (LC50 5.5 uM)||and yeast C. albicans ATCC 10231 (LC50 0.7 uM). Warning: other bacteria not tested. lactoferrin fragment N/A N/A Peptides. 2006 Jan;27(1):1-9. doi: 10.1016/j.peptides.2005.06.012. PubMed|||17485465|||Peptides. 2006 Jan;27(1):1-9. doi: 10.1016/j.peptides.2005.06.012. PubMed 20 FPDB08413 IDR-HH2|||AP03951 VQLRIRVAVIRA Anti-Pseudomonas aeruginosa H103, activity value is MIC = 75 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 38 ug/ml||Anti-Mycobacterium tuberculosis H37Rv, activity value is MIC = 29.3||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 64 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 32 ug/ml||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 128 ug/ml||Anti-Salmonella enterica serovar Typhimurium, activity value is MIC = 32 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 64||Anti-Escherichia coli, activity value is MIC = 64||Anti-Acinetobacter baumannii, activity value is MIC = 32||Anti-Pseudomonas aeruginosa, activity value is MIC = 64||Anti-Mycobacterium tuberculosis H37Rv, activity value is MIC = 37.5 ug/ml||Anti-Mycobacterium tuberculosis WXY, activity value is MIC = 18.75 ug/ml||Anti-Mycobacterium tuberculosis CAS3, activity value is MIC = 75 ug/ml||Anti-Mycobacterium tuberculosis FYX, activity value is MIC = 37.5 ug/ml||Anti-P-aeruginosa PAO1, activity value is MIC > 50 ug/ml||Anti-E. coli, activity value is MIC = 6 ug/ml||Anti-S. typhimurium, activity value is MIC = 12 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-S. epidermidis, activity value is MIC = 12 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 50 ug/ml||Anti-and C. albicans, activity value is MIC = 25 ug/ml Synthetic construct|||Sequence variant of Bac2A, animal-derived, natural derivative Rich Human erythrocytes (50% Hemolysis at 415 ug/ml 23555622, 24982064|||Patent US9017656 12 FPDB08451 ISGCock_Contig15_1337-1|||AP02705 RMKLNAKKLSFC Anti-Escherichia coli ATCC 11775, activity value is MIC > 64 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 64 ug/ml||Anti-Candida albicans ATCC 14053, activity value is MIC = 16 ug/ml||Anti-C. albicans ATCC 14053, activity value is MIC = 16 ug/ml||Antifungal||candidacidal Synthetic construct|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals N/A Rat erythrocytes (0% Hemolysis at 200 ug/ml|||Melittin lysed 99% of rat red blood cells at a con centration of 25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 and Contig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra tion (200 ug/ml). Nevertheless, the hemolytic activities of the peptides ISGCock_Contig13_ 4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, and ISGCock_Contig15_13 37–2 were relatively low compared to that of melittin at a concentration of 100 ug/ml. There fore, the ISGCock_Contig05_0593 and Contig16 _4974 peptides are thought to be effective at doses less than 100 ug/ml, indicating their potential as therapeutic agents against a vast array of microbial infections (Fig 4A). "27167617|||PLoS One . 2016 May 11;11(5):e0155304. doi: 10.1371/journal.pone.0155304. eCollection 2016.|||PLoS One. 2016 May 11;11(5):e0155304. PubMed" 12 FPDB08522 Vespid chemotactic peptide 5e|||DRAMP03682|||Vespid chemotactic peptide 5e|||AP03403 FLPIIAKLLGGLL Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 5 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 25 ug/ml||Anti-Gram+ & Gram-||candidacidal||Chemotactic Vespa magnifica [Hornet]|||Vespa magnifica|||Vespa magnifica [Hornet]|||Venom, Wasp, Vespa magnifica N/A Some vespid chemotactic peptides exhibit hemolytic activities (Ho et al., 1998). Rabbit red blood cells were used to check for hemolytic capability in our experiments. All the peptides had little hemolytic activity on red blood cells even with peptide concentrations up to 50 ug/ml. 16330062|||Toxicon. 2006 Feb;47(2):249-53.||Ref.16330062|||16330062|||Toxicon. 2006 Feb;47(2):249-53. doi: 10.1016/j.toxicon.2005.10.015. PubMed 13 FPDB08523 Vespid chemotactic peptide 5f|||DRAMP03684|||Vespid chemotactic peptide 5f|||AP03404 FLPIPRPILLGLL Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 5 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 25 ug/ml||Anti-Gram+ & Gram-||candidacidal||Chemotactic Vespa magnifica [Hornet]|||Vespa magnifica|||Vespa magnifica [Hornet]|||Venom, Wasp, Vespa magnifica N/A Some vespid chemotactic peptides exhibit hemolytic activities (Ho et al., 1998). Rabbit red blood cells were used to check for hemolytic capability in our experiments. All the peptides had little hemolytic activity on red blood cells even with peptide concentrations up to 50 ug/ml. 16330062|||Toxicon. 2006 Feb;47(2):249-53.||Ref.16330062|||16330062|||Toxicon. 2006 Feb;47(2):249-53. doi: 10.1016/j.toxicon.2005.10.015. PubMed 13 FPDB08524 Vespid chemotactic peptide 5000000 ug|||DRAMP03683|||Vespid chemotactic peptide 5000000 ug|||AP03405 FLIIRRPIVLGLL Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 30 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 10 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 12.5 ug/ml||Anti-Gram+ & Gram-||candidacidal||Chemotactic Vespa magnifica [Hornet]|||Vespa magnifica|||Vespa magnifica [Hornet]|||Venom, Wasp, Vespa magnifica, Asia N/A Some vespid chemotactic peptides exhibit hemolytic activities (Ho et al., 1998). Rabbit red blood cells were used to check for hemolytic capability in our experiments. All the peptides had little hemolytic activity on red blood cells even with peptide concentrations up to 50 ug/ml. 16330062|||Toxicon. 2006 Feb;47(2):249-53.||Ref.16330062|||16330062|||Toxicon. 2006 Feb;47(2):249-53. doi: 10.1016/j.toxicon.2005.10.015. PubMed 13 FPDB08525 Mastoparan-like peptide 12b|||DRAMP03034|||Mastoparan-like peptide 12b|||AP03401 INWKGIAAMKKLL Anti-E. coli ATCC 25922, activity value is MIC = 15 ug/ml||Anti-S. aureus ATCC 2592, activity value is MIC = 3.7 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 7.5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 15 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 3.7 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 7.5 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Vespa magnifica [Hornet]|||Vespa magnifica (Hornet)|||Vespa magnifica [Hornet]|||venom, wasp, Vespa magnifica, Asia N/A VESP-VB1 had a little hemolytic activity of 10.2% on rabbit red blood cells, and of 3.2% on human red blood cells with peptide concentration up to 200 ug/ml, while MP-VB1 had almost no hemolytic activity of 1.7% and 2.7% on rabbit and human red blood cells, respectively, at the concentration of 200 ug/ml. 16330062|||Toxicon. 2006 Feb;47(2):249-253.||Ref.16330062|||16330062|||Peptides. 2008 Nov;29(11):1887-92. doi: 10.1016/j.peptides.2008.07.018. PubMed 13 FPDB09056 CAMPSQ176|||DRAMP03035|||Mastoparan-like peptide 12d|||AP03402 INLKAIAAMAKKLL Anti-E. coli ATCC 25922, activity value is MIC = 3 ug/ml||Anti-S. aureus ATCC 2592, activity value is MIC = 1.5 ug/ml||Anti-C. albicans ATCC 2002, activity value is MIC = 12 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 6 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 3 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal Vespa magnifica [Hornet]|||Vespa magnifica (Hornet)|||Vespa magnifica [Hornet]|||venom, wasp, Vespa magnifica N/A N/A 17046111|||Peptides. 2006 Dec;27(12):3053-3057.|||17046111|||Peptides. 2006 Dec;27(12):3053-7. doi: 10.1016/j.peptides.2006.09.003. PubMed 14 FPDB09060 CAMPSQ711|||DRAMP01388|||OdR1|||AP01302|||DRAMP01388|||AP01302 GFSPNLPGKGLRIS Anti-C. albicans, activity value is MIC = 50 ug/ml||Anti-Candida albicans, activity value is MIC = 50 ug/ml||Antibacterial||Antifungal||Anti-E-coli, activity value is MIC > 50 ug/ml||Anti-S.aureus, activity value is MIC > 100 ug/ml||Anti-B-subtilis, activity value is MIC > 50 ug/ml||Anti-and C. albicans, activity value is MIC = 50 ug/ml||Antimicrobial||candidacidal Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami [Yunnanfu frog]|||skin, Odorrana grahami, China, Asia|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||skin, Odorrana grahami, China, Asia N/A N/A 17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-894.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 14 FPDB09070 CAMPSQ3947|||DRAMP03049|||Eumenine mastoparan-OD|||AP01679|||DRAMP03049|||AP01679 GRILSFIKGLAEHL Antimicrobial||Antibacterial||Antifungal||Anti-Gram+||Anti-Gram-||candidacidal Orancistrocerus drewseni [Solitary wasp]|||Orancistrocerus drewseni (Solitary wasp)|||Orancistrocerus drewseni [Solitary wasp]|||venom, solitary wasp, Orancistrocerus drewseni(Hymenoptera: Eumenidae), South America|||Orancistrocerus drewseni (Solitary wasp)|||venom, solitary wasp, Orancistrocerus drewseni(Hymenoptera: Eumenidae), South America N/A N/A 1985750818695930|||Toxicon. 2010 Apr 1;55(4):711-718.|||1985750818695930|||Toxicon. 2010 Apr 1;55(4):711-8|||Toxicon. 2010 Apr 1;55(4):711-718.Amino Acids. 2009 Jul;37(2):389-394.|||Toxicon. 2010 Apr 1;55(4):711-8 14 FPDB09130 CAMPSQ9906|||CAMPSQ10786|||DRAMP18414|||NDBP-5.8|||AP02762|||DRAMP18414|||DRAMP03769|||AP02762 GILGKIWEGVKSLI Anti-C. albicans SC5314, activity value is MIC = 100 uM||Anti-C. tropicalis ATCC 750, activity value is MIC = 25 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 200 uM||Anti-C. neoformans H99 serotype A, activity value is MIC = 100 uM||Anti-C. neoformans B3501 serotype D, activity value is MIC = 50 uM||A. baumannii Isolate AB 02 [MIC = >25 uM]||A. baumannii Isolate AB 53 [MIC = >25 uM]||A. baumannii Isolate AB 72 [MIC = >25 uM]||Anti-and C. neoformans B3501 serotype D, activity value is MIC = 50 uM||Antibacterial||Antibiofilm||Antifungal||Antimicrobial||candidacidal O. cayaporum|||Opisthacanthus cayaporum|||Opisthacanthus cayaporum|||O. cayaporum|||Opisthacanthus cayaporum|||isthacanthus cayaporum (South American scorpion)|||Opisthacanthus cayaporum N/A "ToAP1, NDBP-4.23: Within the tested concentration range (0.78~100 uM), the hemolysis rate was significantly below 50%, indicating low cytotoxicity and potential value for further study. • NDBP-5.7: At a concentration of 50 uM, the hemolysis rate exceeded 50%, showing relatively high cytotoxicity. • ToAP2: Within the tested concentration range, the hemolysis rate was consistently above 50%, indicating strong cytotoxicity. • ToAP2S1 (ToAP2 modified form): At 25 uM, the hemolysis rate was higher than that of the original peptide ToAP2, and increased hydrophobicity led to enhanced hemolytic activity.|||However,NDBP-5.7presentsahemolysis percent higher than 50% in concentrations up to 50 uM (Figure3D). Comparing the original peptideToAP2 and the modified ToAP2S1, the last one shows a higher hemolysis curve with concentrations up to 25 uM while the ToAP2 maintained its curve above 50%of hemolysis (Figure3A)." "27917162|||30974767|||Front Microbiol. 2016 Nov 18;7:1844.|||27917162|||Front Microbiol . 2016 Nov 18:7:1844. doi: 10.3389/fmicb.2016.01844. eCollection 2016.|||Toxicon. 2009 Sep 1;54(3):252-261.|||Front Microbiol. 2016 Nov 18;7:1844. PubMed" 14 FPDB10586 ToAP1|||AP02758|||DRAMP18418|||ToAP1|||AP02758|||DRAMP18418 FIGMIPGLIGGLISAFK Anti-C. albicans SC5314, activity value is MIC = 50 uM||Anti-C. tropicalis ATCC 750, activity value is MIC = 12.5 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 200 uM||Anti-C. neoformans H99 serotype A, activity value is MIC = 25 uM||Anti-C. neoformans B3501 serotype D, activity value is MIC = 12.5 uM||Antifungal||candidacidal||Antibiofilm||Anti-Candida albicans, activity value is MIC = 50 uM||Anti-Candida tropicalis, activity value is MIC = 12.5 uM||Anti-Candida parapsilosis, activity value is MIC = 200 uM||Anti-Candida glabrata, activity value is MIC > 400 uM||Anti-Candida neoformans, activity value is MIC = 25 uM||Anti-C.parapsilosis ATCC 22019, activity value is MIC = 200 uM||Anti-and C. neoformans B3501 serotype D, activity value is MIC = 12.5 uM||Antimicrobial Tityus obscurus Alpha helix "The document provides hemolytic values for human erythrocytes for 5 antimicrobial peptides from scorpion venom (ToAP2, ToAP2S1, ToAP1, NDBP-4.23, NDBP-5.7), as follows: 1. ToAP2 and ToAP2S1 (Modifier of ToAP2) ToAP2: Within the tested concentration range (up to 100 uM), the hemolysis rate is always higher than 50%, and the red blood cell toxicity is strong. ToAP2S1: As a structural modification of ToAP2, at a lower concentration (25 uM and below), the hemolysis rate is higher than ToAP2. Overall, within the test concentration, the hemolysis rate is also higher than 50%, and due to the increase in hydrophobicity (Table 2), the hemolysis activity is not reduced but increased. 2. ToAP1 At all concentrations tested (0.78-100 uM), the hemolysis rate was significantly less than 50%, and the toxicity to red blood cells was low, which met the potential candidate criteria for subsequent studies (Figure 3B). 3. NDBP-4.23 Similar to ToAP1, the hemolysis rate was consistently below 50% over the full concentration range tested (0.78-100 uM), with low erythrocyte toxicity and potential for further development (Figure 3C). 4. NDBP-5.7 The hemolytic activity was relatively high: at concentrations ≤ 50 uM, the hemolysis rate was already over 50%, and the toxicity to red blood cells was significantly higher than that of ToAP1 and NDBP-4.23 (Figure 3D). Experiment Description -The hemolysis test takes the complete hemolysis induced by 0.1% Triton-X 100 solution as the 100 control and the spontaneous hemolysis induced by PBS buffer as the 0% control. The hemolysis rate is calculated by measuring the absorbance (OD value) of hemoglobin released at 540 nm wavelength. The result is the average of many independent experiments and verified by cytotoxicity test (mouse peritoneal macrophage viability), low hemolytic peptides (such as ToAP1, NDBP-4.23) have low eukaryotic cytotoxicity.|||Exhibits hemolysis against human erythrocytes|||However,NDBP-5.7presentsahemolysis percent higher than 50% in concentrations up to 50 uM (Figure3D). Comparing the original peptideToAP2 and the modified ToAP2S1, the last one shows a higher hemolysis curve with concentrations up to 25 uM while the ToAP2 maintained its curve above 50%of hemolysis (Figure3A)." "27917162|||Front Microbiol. 2016 Nov 18;7:1844. PubMed|||Front Microbiol. 2016 Nov 18;7:1844. eCollection 2016.||Ref.27917162|||27917162|||Front Microbiol . 2016 Nov 18:7:1844. doi: 10.3389/fmicb.2016.01844. eCollection 2016.|||Front Microbiol. 2016 Nov 18;7:1844. eCollection 2016.|||Front Microbiol. 2016 Nov 18;7:1844. PubMed" 17 FPDB10848 Hemoglobin subunit alpha|||Hemoglobin subunit alpha|||AP02860|||AP02860 FKLLSHSLLVTLASHLP Anti-Candida parapsilosis IOC 4564, activity value is MIC = 12.5 uM||Anti-Candida tropicalis IOC 4560, activity value is MIC = 2.1 uM||Anti-Candida albicans MDM8, activity value is MIC = 2.1 uM||Anti-Cryptococcus neoformans var. grubii H99, activity value is MIC = 1.6 uM||Anti-Saccharomyces cerevisiae ATCC 2601, activity value is MIC = 3.1 uM||Anti-Aspergillus niger A296, activity value is MIC = 12.5 uM||Anti-Aspergillus flavus, activity value is MIC = 50 uM||Anti-Aspergillus fumigatus NCPF 2109, activity value is MIC = 6.3 uM||Anti-yeast C. albicans, activity value is MIC = 2.1 uM||Anti-C. parapsilosis, activity value is MIC = 12.5 uM||Anti-C. tropicalis, activity value is MIC = 2.1 uM||Anti-C. neoformans, activity value is MIC = 1.6 uM||Anti-and S. cerevisiae, activity value is MIC = 3.1 uM||Anti-filamentous fungi A. niger, activity value is MIC = 12.5 uM||Anti-A. flavus, activity value is MIC = 50 uM||Anti-A. fumigatus, activity value is MIC = 6.3 uM||Antifungal||candidacidal Synthetic construct|||tick midgut, Rhipicephalus (Boophilus) microplus|||tick midgut, Rhipicephalus (Boophilus) microplus Helix N/A "22749988|||22749988|||Peptides . 2012 Sep;37(1):120-7. doi: 10.1016/j.peptides.2012.05.017. Epub 2012 Jun 27.|||Peptides. 2012 Sep;37(1):120-7. doi: 10.1016/j.peptides.2012.05.017. PubMed" 17 FPDB10897 Longipin|||DRAMP01297|||DRAMP18412|||Longipin|||AP02764|||DRAMP18412|||AP02764 SGYLPGKEYVYKYKGKVF Anti-C.albicans MDM8, activity value is MIC = 35 uM||Anti-C.tropicalis IOC 4560, activity value is MIC = 63 uM||Anti-C.guilliermondii IOC 4557, activity value is MIC = 32 uM||Anti-C.albicans IOC 4558, activity value is MIC = 125 uM||Anti-M.luteus A270, activity value is MIC = 83 uM||Anti-Fungi: C. albicans MDM8, activity value is MIC = 35 uM||Anti-C. tropicalis IOC 4560, activity value is MIC = 63 uM||Anti-C. guilliermondii IOC 4557, activity value is MIC = 32 uM||Anti-C. albicans IOC 4558, activity value is MIC = 125 uM||Anti-M. luteus A270, activity value is MIC = 83 uM||Anti-S. marcescens ATCC4112, activity value is MIC = 60||Anti-C. albicans MDM8, activity value is MIC = 15||Anti-C. guilliermondii and C. tropicalis, activity value is MIC = 3.8||Anti-S. aureus ATCC29213000000 uM, activity value is MIC > 120 uM||Anti-S. epidermidis ATCC12228, activity value is MIC > 120 uM||Anti-M.luteus BR2, activity value is MIC > 120 uM||Anti-M. luteus A270, activity value is MIC = 60||Anti-P. aeruginosa ATCC27853, activity value is MIC = 60||Anti-E.coli D31 or SBS363, activity value is MIC > 120 uM||Anti-E.cloacae beta12, activity value is MIC > 120 uM||Anti-C. albicans MDM8 or IOC4558, activity value is MIC = 7.5||Anti-C. guilliermondii, activity value is MIC = 3.8||Anti-filamentous fungi A.niger, activity value is MIC > 120 uM||Anti-C.herbarum ATCC26362, activity value is MIC > 120 uM||Anti-and P.farinosus IBCB251, activity value is MIC > 120 uM||Antifungal||candidacidal Acutisoma longipes [Neotropical harvestman]|||Acutisoma longipes (Neotropical harvestman) (Goniosoma longipes)|||hemolymph, Acutisoma longipes|||hemolymph, Acutisoma longipes|||hemolymph, Acutisoma longipes N/A No hemolytic activity against human RBC upto 125 uM.|||No hemolytic activity against human RBC upto 125 uM "uniprot|||Submitted (OCT-2013) to the EMBL/GenBank/DDBJ database|||PLoS One. 2016 Dec 20;11(12):e0167953.|||PLoS One . 2016 Dec 20;11(12):e0167953. doi: 10.1371/journal.pone.0167953. eCollection 2016.|||PLoS One. 2016 Dec 20;11(12):e0167953. PubMed" 18 FPDB11316 ISGCock_Contig15_1337-2|||ISGCock_Contig15_1337-2|||AP02706|||AP02706 HNSSKQWSHWLWHNGIRI Anti-Escherichia coli ATCC 11775, activity value is MIC > 64 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC > 64 ug/ml||Anti-Candida albicans ATCC 14053, activity value is MIC = 64 ug/ml||Anti-C. albicans ATCC 14053, activity value is MIC = 64 ug/ml||Antifungal||candidacidal Synthetic construct|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals|||AI predicted from the American Cockroach Periplaneta americana, insects, arthropods, invertebrates, animals N/A Rat erythrocytes (0% Hemolysis at 200 ug/ml|||Melittin lysed 99% of rat red blood cells at a con centration of 25 ug/ml, whereas no hemolytic activity was observed for the 11 synthetic pep tides at this concentration and up to 50 ug/ml, although the ISGCock_Contig05_0593 and Contig16_4974 peptides showed relatively strong hemolytic activity even at a high concentra tion (200 ug/ml). Nevertheless, the hemolytic activities of the peptides ISGCock_Contig13_ 4610–1, ISGCock_Contig12_4176, ISGCock_Contig15_1337–1, and ISGCock_Contig15_13 37–2 were relatively low compared to that of melittin at a concentration of 100 ug/ml. There fore, the ISGCock_Contig05_0593 and Contig16 _4974 peptides are thought to be effective at doses less than 100 ug/ml, indicating their potential as therapeutic agents against a vast array of microbial infections (Fig 4A). "27167617|||27167617|||PLoS One . 2016 May 11;11(5):e0155304. doi: 10.1371/journal.pone.0155304. eCollection 2016.|||PLoS One. 2016 May 11;11(5):e0155304. PubMed" 18 FPDB11463 Phylloseptin-3.3TR|||Phylloseptin-3.3TR|||AP02993|||AP02993 FFSMIPKIATGIASLVKDL Anti-E. coli, activity value is MIC > 100 uM||Anti-S. epidermis, activity value is MIC > 100 uM||Anti-C. albicans, activity value is MIC = 100 uM||Antifungal||candidacidal Phyllomedusa trinitatis [Trinidad leaf frog ]|||Trinidadian leaf frog, Phyllomedusa trinitatis,|||Trinidadian leaf frog, Phyllomedusa trinitatis, N/A N/A "29980138|||29980138|||Comp Biochem Physiol Part D Genomics Proteomics . 2018 Dec:28:72-79. doi: 10.1016/j.cbd.2018.06.006. Epub 2018 Jun 30.|||Comp Biochem Physiol Part D Genomics Proteomics. 2018 Jun 30;28:72-79. doi: 10.1016/j.cbd.2018.06.006. PubMed" 19 FPDB11471 FP|||DRAMP31536|||AP05269|||DRAMP31536|||AP05269 MGRFKRFRKKFKKLFKKLS Anti-Cronobacter sakazakii, activity value is MIC = 125 ug/ml||Antimicrobial||Antiviral||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-4 strains S. aureus, activity value is MIC = 2||Anti-B. megaterium Bm 11, activity value is MIC = 2 uM||Anti-B. subtilis KCTC 3068, activity value is MIC = 4 uM||Anti-S. epidermidis KCTC 1917, activity value is MIC = 4 uM||Anti-10 strains E. faecalis, activity value is MIC = 8||Anti-5 strains E. faecium, activity value is MIC = 8||Anti-3 strains S. agalactiae, activity value is MIC = 1||Anti-10 strains A. baumannii, activity value is MIC = 0.5||Anti-3 strains E. coli, activity value is MIC = 2||Anti-S. typhimurium ATCC 14028, activity value is MIC = 4 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-S. marcescens ATCC 8100, activity value is MIC = 2 uM||Anti-C. albicans, activity value is MIC = 16 uM||Anti-C. neoformans, activity value is MIC = 4 uM||Anti-E-coli ESBL, activity value is MIC > 50 uM||Anti-P-aeruginosa, activity value is MIC > 50 uM||Anti-A-baumannii, activity value is MIC > 50 uM Synthetic construct|||Amino acid extension, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Amino acid extension, cathelicidin analog, animal-derived, natural derivative Helix "Human erythrocytes( 0.34% hemolysis at 500 ug/ml)|||The document mentions the hemolytic results of the antimicrobial peptide bomidin, specifically as follows: - In hemolysis experiments with mouse red blood cells, bomidin at concentrations of 0.5, 1, 2, and 4000 μg/ml did not cause hemolysis at 1, 2, 3, or 4 hours; - Slight hemolysis was observed at concentrations of 8000 μg/ml and 16000 μg/ml; - More obvious hemolysis occurred at concentrations of 32000 μg/ml and 64000 μg/ml. In conclusion, bomidin has no hemolytic activity at concentrations ≤4000 μg/ml, while hemolysis occurs to varying degrees at concentrations of 8000 μg/ml and above." 30716944|||Front Immunol. 2022 May 19;13:851642.|||Probiotics Antimicrob Proteins. 2022 Feb;14(1):169-179. doi: 10.1007/s12602-021-09857-6. PubMed|||Front Immunol. 2022 May 19;13:851642.|||Probiotics Antimicrob Proteins. 2022 Feb;14(1):169-179. doi: 10.1007/s12602-021-09857-6. PubMed 19 FPDB11889 Antimicrobial peptide EP-20|||DRAMP02399|||AP01970|||DRAMP02399|||AP01970 EGPVGLADPDGPASAPLGAP Antibacterial ; Xenorhabdus budapestensis||Antibacterial ; Phytophthora capsici (2.76 +/- 0.04mm colony diameter at 20 ug )||Verticillium dahliae (19.32 +/- 1.31mm colony diameter at 20 ug )||Fusarium graminearum (12.45 +/- 1.6mm colony diameter at 20 ug )||Fusarium omysporum (21.29 +/- 1.1mm colony diameter at 20 ug )||Antimicrobial||Antifungal||Only showed weak antibacterial activity. Active against fungi: P. capsici (87.22% inhibition)||V. dahliae (40.55% inhibition)||F. graminearum (21.35% inhibition)||and F. omysporum (15.98% inhibition). Interstingly||the same peptide has also been identified in Lactobacillus crustorum MN047 . Inhibition zone assays reveal broad-spectrum activity. active against Gram+ S. aureus ATCC 29213||25923 (15.3-17.4 mm)||E. faecalis ATCC 29212 (10.2 mm)||L. monocytogenes CMCC 54004 (12.1 mm)||Gram- E. coli ATCC 25922 (12.3 mm)||Salmonella CMCC 50071 (12.1 mm)||C. sakazakii ATCC 29544 (15 mm)||also active against antibiotic0resistant C. sakazakii (14.6-18.1 mm) and Salmonella 557D (12 mm). Found in multiple species. UPdated 7/2021 Xenorhabdus budapestensis|||Xenorhabdus budapestensis|||Xenorhabdus budapestensis NMC-10 also Lactobacillus crustorum MN047|||Xenorhabdus budapestensis NMC-10 also Lactobacillus crustorum MN047 N/A "Phytophthora capsici (2.76 +/- 0.04mm colony diameter at 20 ug ), Verticillium dahliae (19.32 +/- 1.31mm colony diameter at 20 ug ), Fusarium graminearum (12.45 +/- 1.6mm colony diameter at 20 ug ), Fusarium omysporum (21.29 +/- 1.1mm colony diameter at 20 ug )|||The abilities of the synthetic hymenochirins to inhibit the growth of reference strains of the Gram-positive bacterium S. aureus, the Gram-negative bacteria E. coli, K. pneumoniae, and P. aeruginosa, and the opportunistic yeast pathogen C. albicans are compared in Table 1. The MIC values for hymenochirin-5B may be artefactually high because of the restricted solubility of the peptide in Mueller-Hinton broth and its tendency to form a gel in con- centrated solution. All peptides displayed relatively low hemolytic activities against human erythrocytes (LC50 in the range 160 to >305 ␮M)." "https://pubmed.ncbi.nlm.nih.gov/22497806|||Peptides. 2012 Jun;35(2):253-260.|||Peptides . 2012 Jun;35(2):253-60. doi: 10.1016/j.peptides.2012.03.027. Epub 2012 Apr 3.||Yi et al., 2018|||Peptides. 2012 Jun;35(2):253-260.|||Peptides. 2012 Jun;35(2):253-60. PubMed." 20 FPDB12271 Nigrocin-OG4|||DRAMP01420|||Nigrocin-OG4|||AP01310|||DRAMP01420|||AP01310 GLLSGILGAGKHIICGLSGLC Anti-C. albicans, activity value is MIC = 1.1 ug/ml||Anti-Escherichia coli, activity value is MIC > 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC > 100 ug/ml||Anti-Bacillus subtilis, activity value is MIC > 100 ug/ml||Anti-E.coli, activity value is MIC > 100 uM||Anti-S.aureus, activity value is MIC > 100 ug/ml||Anti-B.subtilis, activity value is MIC > 100 ug/ml||Anti-and C. albicans, activity value is MIC = 1.1 uM||Antifungal||candidacidal||Hemolytic Odorrana grahami [Yunnanfu frog]|||Odorrana grahami (Yunnanfu frog)|||skin, Odorrana grahami, China, Asia|||Odorrana grahami (Yunnanfu frog)|||skin, Odorrana grahami, China, Asia N/A At a concentration of 50 µg/ml, the hemolysis rate of Odorranain-A1 was 12.7%, Odorranain-F1 was 15.4%, Odorranain-H1 was 21.6%, Odorranain-L1 was 18.3%, Odorranain-M1 was 8.2%, Odorranain-P1a was 11.2%, Odorranain-P2a was 15.2%, Odorranain-Q1 was 22.9%, Odorranain-V1 was 23.9%, Odorranain-W1 was 17.6%, Nigrocin-OG2 was 60.0%, Nigrocin-OG4 was 65.5%, Nigrocin-OG5 was 87.2%, Nigrocin-OG21 was 100%.|||[Ref.17272268] RCH=65.5 ± 7.7% against rabbit red blood cells at 50 ug/ml. RCH, red cell hemolysis.|||[Ref.17272268] RCH=65.5 ± 7.7% against rabbit red blood cells at 50 ug/ml. RCH, red cell hemolysis.|||65.6% hemolysis at 50 ug/ml. "17272268|||Mol Cell Proteomics. 2007 May;6(5):882-894.|||17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Gram-negative bacterium: Escherichia coli (MIC>100 ug/ml); Gram-positive bacteria: Staphylococcus aureus (MIC>100 ug/ml), Bacillus subtilis (MIC>100 ug/ml). Yeast: Candida albicans (MIC=1.1 ug/ml).|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med." 21 FPDB13541 ToAP2|||AP02759|||DRAMP18417|||ToAP2|||AP02759|||DRAMP18417 FFGTLFKLGSKLIPGVMKLFSKKKER Anti-C. albicans SC5314, activity value is MIC = 12.5 uM||Anti-C. tropicalis ATCC 750, activity value is MIC = 3.12 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 50 uM||Anti-C. glabrata ATCC 90030, activity value is MIC = 200 uM||Anti-C. neoformans H99 serotype A, activity value is MIC = 12.5 uM||Anti-C. neoformans B3501 serotype D, activity value is MIC = 6.25 uM||Antifungal||candidacidal||Antibiofilm||Anti-Candida albicans, activity value is MIC = 12.5 uM||Anti-Candida tropicalis, activity value is MIC = 3.12 uM||Anti-Candida parapsilosis, activity value is MIC = 50 uM||Anti-Candida glabrata, activity value is MIC = 200 uM||Anti-Candida neoformans, activity value is MIC = 12.5 uM||Anti-and C. neoformans B3501 serotype D, activity value is MIC = 6.25 uM||Antimicrobial Tityus obscurus|||Opistophthalmus carinatus (African yellow leg scorpion) Helix||Alpha helix "Exhibits hemolysis against human erythrocytes|||The document provides hemolytic values for human erythrocytes for 5 antimicrobial peptides from scorpion venom (ToAP2, ToAP2S1, ToAP1, NDBP-4.23, NDBP-5.7), as follows: 1. ToAP2 and ToAP2S1 (Modifier of ToAP2) ToAP2: Within the tested concentration range (up to 100 uM), the hemolysis rate is always higher than 50%, and the red blood cell toxicity is strong. ToAP2S1: As a structural modification of ToAP2, at a lower concentration (25 uM and below), the hemolysis rate is higher than ToAP2. Overall, within the test concentration, the hemolysis rate is also higher than 50%, and due to the increase in hydrophobicity (Table 2), the hemolysis activity is not reduced but increased. 2. ToAP1 At all concentrations tested (0.78-100 uM), the hemolysis rate was significantly less than 50%, and the toxicity to red blood cells was low, which met the potential candidate criteria for subsequent studies (Figure 3B). 3. NDBP-4.23 Similar to ToAP1, the hemolysis rate was consistently below 50% over the full concentration range tested (0.78-100 uM), with low erythrocyte toxicity and potential for further development (Figure 3C). 4. NDBP-5.7 The hemolytic activity was relatively high: at concentrations ≤ 50 uM, the hemolysis rate was already over 50%, and the toxicity to red blood cells was significantly higher than that of ToAP1 and NDBP-4.23 (Figure 3D). Experiment Description -The hemolysis test takes the complete hemolysis induced by 0.1% Triton-X 100 solution as the 100 control and the spontaneous hemolysis induced by PBS buffer as the 0% control. The hemolysis rate is calculated by measuring the absorbance (OD value) of hemoglobin released at 540 nm wavelength. The result is the average of many independent experiments and verified by cytotoxicity test (mouse peritoneal macrophage viability), low hemolytic peptides (such as ToAP1, NDBP-4.23) have low eukaryotic cytotoxicity.|||Hemolytic activity data of antifungal peptides derived from scorpion venom (based on human red blood cell hemolysis assay, concentration range 0.78–100 μM) • ToAP1: Hemolysis rate at all tested concentrations was significantly below 50%, indicating low cytotoxicity. • ToAP2: Hemolysis rate remained above 50% within the concentration range, indicating strong hemolytic activity. • ToAP2S1 (ToAP2 modified analog): Hemolysis rate exceeded 50% at concentrations ≥25 μM, showing higher hemolytic activity than the original peptide ToAP2. • NDBP-4.23: Hemolysis rate at all tested concentrations was significantly below 50%, showing excellent cell selectivity. • NDBP-5.7: Hemolysis rate exceeded 50% at concentrations ≥50 μM, indicating strong hemolytic activity.|||Exhibits hemolysis against human erythrocytes|||However,NDBP-5.7presentsahemolysis percent higher than 50% in concentrations up to 50 uM (Figure3D). Comparing the original peptideToAP2 and the modified ToAP2S1, the last one shows a higher hemolysis curve with concentrations up to 25 uM while the ToAP2 maintained its curve above 50%of hemolysis (Figure3A)." "27917162|||Front Microbiol. 2016 Nov 18;7:1844. PubMed|||Front Microbiol. 2016 Nov 18;7:1844. eCollection 2016.||Ref.27917162|||27917162|||Front Microbiol . 2016 Nov 18:7:1844. doi: 10.3389/fmicb.2016.01844. eCollection 2016.|||Front Microbiol. 2016 Nov 18;7:1844. eCollection 2016.|||Front Microbiol. 2016 Nov 18;7:1844. PubMed" 26 FPDB13751 Con10|||AP02761|||DRAMP18415|||Con10|||AP02761|||DRAMP18415|||DRAMP03690 FWSFLVKAASKILPSLIGGGDDNKSSS Anti-C. albicans SC5314, activity value is MIC = 100 uM||Anti-C. tropicalis ATCC 750, activity value is MIC = 12.5 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 200 uM||Anti-C. glabrata ATCC 90030, activity value is MIC = 200 uM||Anti-C. neoformans H99 serotype A, activity value is MIC = 50 uM||Anti-C. neoformans B3501 serotype D, activity value is MIC = 25 uM||Antifungal||candidacidal||Antibiofilm||Anti-and C. neoformans B3501 serotype D, activity value is MIC = 25 uM||Antimicrobial O. cayaporum|||Opisthacanthus cayaporum|||Opisthacanthus cayaporum|||O. cayaporum|||Opisthacanthus cayaporum|||Opisthacanthus cayaporum (South American scorpion) N/A "The document provides hemolytic values for human erythrocytes for 5 antimicrobial peptides from scorpion venom (ToAP2, ToAP2S1, ToAP1, NDBP-4.23, NDBP-5.7), as follows: 1. ToAP2 and ToAP2S1 (Modifier of ToAP2) ToAP2: Within the tested concentration range (up to 100 uM), the hemolysis rate is always higher than 50%, and the red blood cell toxicity is strong. ToAP2S1: As a structural modification of ToAP2, at a lower concentration (25 uM and below), the hemolysis rate is higher than ToAP2. Overall, within the test concentration, the hemolysis rate is also higher than 50%, and due to the increase in hydrophobicity (Table 2), the hemolysis activity is not reduced but increased. 2. ToAP1 At all concentrations tested (0.78-100 uM), the hemolysis rate was significantly less than 50%, and the toxicity to red blood cells was low, which met the potential candidate criteria for subsequent studies (Figure 3B). 3. NDBP-4.23 Similar to ToAP1, the hemolysis rate was consistently below 50% over the full concentration range tested (0.78-100 uM), with low erythrocyte toxicity and potential for further development (Figure 3C). 4. NDBP-5.7 The hemolytic activity was relatively high: at concentrations ≤ 50 uM, the hemolysis rate was already over 50%, and the toxicity to red blood cells was significantly higher than that of ToAP1 and NDBP-4.23 (Figure 3D). Experiment Description -The hemolysis test takes the complete hemolysis induced by 0.1% Triton-X 100 solution as the 100 control and the spontaneous hemolysis induced by PBS buffer as the 0% control. The hemolysis rate is calculated by measuring the absorbance (OD value) of hemoglobin released at 540 nm wavelength. The result is the average of many independent experiments and verified by cytotoxicity test (mouse peritoneal macrophage viability), low hemolytic peptides (such as ToAP1, NDBP-4.23) have low eukaryotic cytotoxicity.|||ToAP1, NDBP-4.23: Within the tested concentration range (0.78~100 uM), the hemolysis rate was significantly below 50%, indicating low cytotoxicity and potential value for further study. • NDBP-5.7: At a concentration of 50 uM, the hemolysis rate exceeded 50%, showing relatively high cytotoxicity. • ToAP2: Within the tested concentration range, the hemolysis rate was consistently above 50%, indicating strong cytotoxicity. • ToAP2S1 (ToAP2 modified form): At 25 uM, the hemolysis rate was higher than that of the original peptide ToAP2, and increased hydrophobicity led to enhanced hemolytic activity.|||However,NDBP-5.7presentsahemolysis percent higher than 50% in concentrations up to 50 uM (Figure3D). Comparing the original peptideToAP2 and the modified ToAP2S1, the last one shows a higher hemolysis curve with concentrations up to 25 uM while the ToAP2 maintained its curve above 50%of hemolysis (Figure3A)." "27917162|||Front Microbiol. 2016 Nov 18;7:1844. PubMed|||Front Microbiol. 2016 Nov 18;7:1844|||27917162|||Front Microbiol . 2016 Nov 18:7:1844. doi: 10.3389/fmicb.2016.01844. eCollection 2016.|||Toxicon. 2008 Jun 15;51(8):1499-1508.|||Front Microbiol. 2016 Nov 18;7:1844. PubMed" 27 FPDB13936 AC-AMP1|||DRAMP00976|||AC-AMP1|||AP01584|||DRAMP00976|||AP01584 VGECVRGRCPSGMCCSQFGYCGKGPKYCG Antibacterial||Antifungal||Antimicrobial||Anti-Gram+ Amaranthus caudatus [Love-lies-bleeding]|||Amaranthus caudatus (Love-lies-bleeding) (Inca-wheat)|||Amaranthus caudatus [Love-lies-bleeding]|||Seeds, Amaranthus caudatus|||Hordeum vulgare (Barley)|||Seeds, Amaranthus caudatus Bridge N/A 1567877|||Biochemistry. 1992 May 5;31(17):4308-4314.|||1567877|||Biochemistry. 1992 May 5;31(17):4308-14|||FEBS Lett. 2005 Apr 25;579(11):2301-2306.|||Biochemistry. 1992 May 5;31(17):4308-14 29 FPDB14112 Pleurain M1|||Pleurain M1|||AP02268|||DRAMP20783|||AP02268 GLLDSVKEGLKKVAGQLLDTLKCKISGCTPA Antibacterial||Antifungal||Anti-E. coli, activity value is MIC = 6.3 ug/ml||Anti-S. aureus, activity value is MIC = 6.3 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 25 ug/ml||Anti-C. albicans, activity value is MIC = 12.5 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 6.3 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 12.5 ug/ml||Anti-Escherichia coli, activity value is MIC = 6.3 ug/ml||Anti-##Gram-positive bacteria: Staphylococcus aureus, activity value is MIC = 6.3 ug/ml||Anti-##Yeast: Candida albicans, activity value is MIC = 12.5 ug/ml||candidacidal Rana pleuraden|||Rana pleuraden|||skin secretions, Rana pleuraden, China, Asia|||Nidirana pleuraden (Yunnan pond frog)|||skin secretions, Rana pleuraden, China, Asia N/A No hemolysis information or data found in the reference(s) presented in this entry "19028675|||19028675|||Mol Cell Proteomics . 2009 Mar;8(3):571-83. doi: 10.1074/mcp.M800297-MCP200. Epub 2008 Nov 26.|||Mol Cell Proteomics. 2009 Mar;8(3):571-83.||Ref.19028675|||Mol Cell Proteomics. 2009 Mar;8(3):571-83. Pub-Med" 31 FPDB14298 Es-Termicin, Termicin-like protein|||Es-Termicin, Termicin-like protein|||AP02652|||AP02652 ACDFQQCWVTCQRQYSINFISARCNGDSCVCTFRT Antibacterial||Antifungal||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 200 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 50 ug/ml||Anti-Candida albicans ATCC 90028, activity value is MIC = 25 ug/ml||Anti-Candida albicans ATCC 90030, activity value is MIC = 50 ug/ml||Anti-Candida parapsilosis ATCC 22019, activity value is MIC = 100 ug/ml||candidacidal Eupolyphaga sinensis Bridge Human erythrocytes (- at NA|||Human red blood cells were used to check for hemolytic capability in our experiments. Es-termicin had little hemolytic activity on red blood cells even with peptide concentration up to 400 ug/ml. "26823660|||26823660|||J Venom Anim Toxins Incl Trop Dis . 2016 Jan 28:22:5. doi: 10.1186/s40409-016-0058-7. eCollection 2016.|||J Venom Anim Toxins Incl Trop Dis. 2016 Jan 28;22:5. doi: 10.1186/s40409-016-0058-7. PubMed" 35 FPDB14343 HmdSL-37, Antibacterial protein LL-37|||DRAMP02727|||HmdSL-37, Antibacterial protein LL-37|||AP00734|||AP00734 SLGNFFRKARKKIGEEFKRIVQRIKDFLQHLIPRTEA Antibacterial||Antifungal||Anti-In 20% TSB in SPB medium Escherichia coli, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 uM||Anti-Staphylococcus aureus, activity value is MIC > 32 uM||Anti-Enterococcus faecalis, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 2 uM||Anti-Staphylococcus aureus, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 16||Anti-Staphylococcus aureus, activity value is MIC = 8||Anti-Enterococcus faecalis, activity value is MIC > 32 uM||Anti-In 20% TSB in SPB medium E. coli, activity value is MIC = 2 uM||Anti-P. aeruginosa, activity value is MIC = 8 uM||Anti-S. aureus, activity value is MIC > 32 uM||Anti-E. faecalis, activity value is MIC = 8 uM||Anti-Gram+ & Gram-||candidacidal Hylobates moloch [Gibbon]|||Hylobates sp. (Gibbon)|||Hylobates moloch [Gibbon]|||Gibbon|||Gibbon Helix "The hemolytic values of six primate antimicrobial peptides (hssLL-37, ppyLL-37, hmdSL-37, mmuRL-37, pobRL-37, cjaRL-37) are as follows: At a concentration of 10 μM in PBS buffer, the hemolysis rate of hssLL-37 was 45%, hmdSL-37 was 85%, ppyLL-37 was 100%, mmuRL-37 was 100%, pobRL-37 was 20%, and cjaRL-37 was 0%; At a concentration of 100 μM in PBS buffer, the hemolysis rate of cjaRL-37 was 15%, while the exact hemolysis rates of the other five peptides were not explicitly provided, though mmuRL-37, hmdSL-37, and ppyLL-37 were mentioned to have high cytotoxicity (suggesting a significant increase in hemolysis rate).|||The hemolysis rate reaches 45-55% at 10 uM." 16720578|||J Biol Chem. 2006 Jul 21;281(29):19861-19871.|||16720578|||J Biol Chem 2006; 281: 19861-71. PubMed.|||J Biol Chem 2006; 281: 19861-71. PubMed. 37 FPDB14344 PobRL-37|||DRAMP03190|||PobRL-37|||AP00735|||AP00735 RLGNFFRKAKKKIGRGLKKIGQKIKDFLGNLVPRTES Antibacterial||Antifungal||Anti-In 20% TSB in SPB medium: Escherichia coli, activity value is MIC = 0.5 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 0.5||Anti-Staphylococcus aureus, activity value is MIC = 2 uM||Anti-Enterococcus faecalis, activity value is MIC = 2||Anti-Pseudomonas aeruginosa, activity value is MIC = 1||Anti-Staphylococcus aureus, activity value is MIC = 0.5 uM||Anti-Enterococcus faecalis, activity value is MIC = 1||Anti-In 20% TSB in SPB medium E. coli ML-35, activity value is MIC = 0.5 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 0.5||Anti-S. aureus 710A, activity value is MIC = 2 uM||Anti-E. faecalis A16, activity value is MIC = 2||Anti-P. aeruginosa, activity value is MIC = 1||Anti-S. aureus, activity value is MIC = 0.5 uM||Anti-E. faecalis, activity value is MIC = 1||Anti-Gram+ & Gram-||candidacidal Cercopithecidae [Old World monkeys]|||Cercopithecidae|||Cercopithecidae [Old World monkeys]|||cercopithecidae Helix hssLL-37 (human): 10 uM hemolysis rate 45%, 100 uM hemolysis rate 85%; hmdSL-37 (gibbon): 10 uM hemolysis rate 100%, 100 uM hemolysis rate 100%; mmuRL-37 (rhesus monkey): 10 uM hemolysis rate 20%, 100 uM hemolysis rate 100%; pobRL-37 (leaf monkey): 10 uM hemolysis rate 0%, 100 uM hemolysis rate 100%; ppyLL-37 (Gorilla): 10 uM hemolysis rate 0%, 100 uM hemolysis rate 100%; cjaRL-37 (capuchin monkey): 10 uM hemolysis rate 0%, 100 uM hemolysis rate 15% (reference: 0.2% Triton X-100 induced complete hemolysis with 100%, testing system using PBS buffer containing 0.5% human red blood cells).|||The hemolysis rate is only 20-30% at 10 uM. 16720578|||J Biol Chem. 2006 Jul 21;281(29):19861-19871.|||16720578|||J Biol Chem 2006; 281: 19861-71. PubMed.|||J Biol Chem 2006; 281: 19861-71. PubMed. 37 FPDB14351 EcAMP1|||DRAMP00387|||EcAMP1|||AP01760|||DRAMP00387|||AP01760 GSGRGSCRSQCMRRHEDEPWRVQECVSQCRRRRGGGD Antibacterial||Antifungal||Antimicrobial||Anti-P. syringae, activity value is MIC = 24 uM||Anti-C. michiganensis, activity value is MIC = 24 uM||Anti-E. carotovora, activity value is MIC = 11.9 uM Echinochloa crus-galli [Barnyard grass]|||Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli)|||Echinochloa crus-galli [Barnyard grass]|||seeds, Echinochloa crus-galli|||Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli)|||seeds, Echinochloa crus-galli Alpha helix (3 helices; 20 residues)||Helix N/A 24275143|||Peptides. 2012 Nov;38(1):33-40.|||21561864|||24275143|||J Biol Chem. 2011 Jul 15;286(28):25145-53|||Peptides. 2012 Nov;38(1):33-40.J Biol Chem. 2011 Jul 15;286(28):25145-25153.|||J Biol Chem. 2011 Jul 15;286(28):25145-53 37 FPDB14428 Cecropin-B|||DRAMP03090|||AP01563|||AP01563 GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR Antibacterial||Anti-Escherichia coli D21, activity value is MIC = 1.8 uM||Anti-Enterobacter cloacae b12, activity value is MIC = 1 uM||Anti-Pseudomonas aeruginosa OT97, activity value is MIC = 4.2 uM||Anti-Bacillus megatherium Bm11, activity value is MIC = 3.7 uM||Anti-Bacillus subtilis Bsll, activity value is MIC = 3.2 uM||Anti-Micrococcus luteus MI11, activity value is MIC = 59 uM||Antifungal Drosophila melanogaster [Fruit fly]|||Drosophila melanogaster (Fruit fly)|||fruit fly, Drosophila melanogaster|||fruit fly, Drosophila melanogaster N/A N/A 2390977|||EMBO J. 1990 Sep;9(9):2969-2976.|||EMBO J. 1990 Jan;9(1):217-24|||EMBO J. 1990 Jan;9(1):217-24 39 FPDB14451 Beta-amyloid peptide|||Beta-amyloid peptide|||AP01675|||AP01675 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV Antibacterial||Antifungal||Anti-Candida albicans ATCC 10231, activity value is MIC = 0.78 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1.56 ug/ml||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 50 ug/ml||Anti-Streptococcus pneumoniae ATCC 49619, activity value is MIC = 12.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Listeria monocytogenes, activity value is MIC = 25 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 50 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 12.5 ug/ml||Anti-Streptococcus agalactiae, activity value is MIC = 50 ug/ml||Anti-P. aeruginosa, activity value is MIC > 50 ug/ml||Anti-S. pyogenes, activity value is MIC > 50 ug/ml||Anti-S. mitis, activity value is MIC = 50 ug/ml||Anti-S. salivarius, activity value is MIC > 50 ug/ml||The discovery of antimicrobial property of this peptide adds a new avenue to understanding the mechanism of the Alzhermer's disease. It also inhibits Herpes simplex virus 1 (HSV-1) . Although less effective than the 42mer||it also inhibits influenza A virus (White et al. 2014 ).||Anti-Gram+ & Gram-||Antiviral||Synergistic AMPs Homo sapiens [Humans]|||Homo sapiens [Humans]|||Homo sapiens|||Homo sapiens Helix N/A 20209079|||20209079|||PLoS One. 2010 Mar 3;5(3):e9505||Bourgade K et al., 2014|||PLoS One. 2010 Mar 3;5(3):e9505 40 FPDB14536 ToAMP4|||AP02236 GYGDGCYSEDDLSVCCKKKFKVIGKCFKSVRECQNSGCKYH Antibacterial||Antifungal Taraxacum officinale|||flowers, Taraxacum officinale Bridge N/A "23771034|||Plant Physiol Biochem . 2013 Sep:70:93-9. doi: 10.1016/j.plaphy.2013.05.022. Epub 2013 May 28.|||Plant Physiol Biochem. 2013 May 28;70C:93-99. Pub-Med." 41 FPDB14599 Galleria defensin|||DRAMP03528|||AP00751|||AP00751 DTLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFLNVNCWCE Antibacterial||Anti-Aspergillus niger, activity value is MIC = 2.1 uM||Anti-Candida albicans, activity value is MIC = 8.5 uM||Anti-C. fructus, activity value is MIC = 8.5 uM||Anti-Fusarium oxysporum, activity value is MIC = 16.9 uM||Anti-Pichia pastoris, activity value is MIC = 16.9 uM||Anti-Pachysolen tannophilus, activity value is MIC = 8.5 uM||Anti-Trichoderma harzianum, activity value is MIC = 4.2 uM||Anti-Zygosaccharomyces Marxianus, activity value is MIC = 8.5 uM||Anti-Yeast and yeast-like fungi P. pastoris, activity value is MIC = 16.9 uM||Anti-Z. marxianus, activity value is MIC = 8.5 uM||Anti-P. tannophilus, activity value is MIC = 8.5 uM||Anti-C. albicans, activity value is MIC = 8.5 uM||Anti-Filamentous fungi F. oxysporum, activity value is MIC = 16.9 uM||Anti-A. niger, activity value is MIC = 2.1 uM||Anti-and T. harzianum, activity value is MIC = 4.2 uM||Antifungal||candidacidal Galleria mellonella [Greater wax moth]|||Galleria mellonella (Greater wax moth)|||fat body, midgut, wax moth, Galleria mellonella|||wax moth, Galleria mellonella N/A N/A 14728668|||Insect Mol Biol 2004; 13: 65-72.|||Insect Mol Biol 2004; 13: 65-72|||Insect Mol Biol 2004; 13: 65-72 43 FPDB14603 Coprisin|||AP01976|||DRAMP04668 VTCDVLSFEAKGIAVNHSACALHCIALRKKGGSCQNGVCVCRN Antibacterial||Antifungal||Anti-inflammatory||Antibiofilm||Wound healing||Anti-multiple fungi with, activity value is MIC = 5||No MICs found in DRAMP database Copris tripartitus|||Dung Beetle, Copris tripartitus. Combine Helix and Beta structure No hemolysis information or data found in the reference(s) presented in this entry "23137439|||Int J Pept. 2009;2009. pii: 136284. PubMed|||Int J Pept . 2009:2009:136284. doi: 10.1155/2009/136284. Epub 2009 Oct 22.|||Biochim Biophys Acta. 2013 Feb;1828(2):271-283." 43 FPDB14766 CCL27|||AP02187 PPSTACCTQLYRKPLSDKLLRKVIQVELQEADGDCHLQAFVLHLAQRSICIHPQNP Anti-Pseudomonas aeruginosa, activity value is IC50 > 10 uM||Anti-Klebsiella pneumoniae, activity value is IC50 > 10 uM||Anti-Streptococcus mutans, activity value is IC50 > 10 uM||Anti-Streptococcus pyogenes, activity value is IC50 > 10 uM||Anti-Staphylococcus aureus, activity value is IC50 > 10 uM||Anti-Candida albicans, activity value is IC50 = 5.0||Anti-C. albicans, activity value is IC50 = 5.0||Antifungal||candidacidal||Chemotactic Homo sapiens [Human]|||skin, Homo sapiens Combine Helix and Beta structure N/A "12538707|||J Immunol . 2003 Feb 1;170(3):1452-61. doi: 10.4049/jimmunol.170.3.1453.|||J Immunol. 2003 Feb 1;170(3):1452-61.Pub-Med." 56 FPDB15084 CXCL14|||AP01372|||DRAMP04591 "SKCKCSRKGPKIRYSDVKKLEMKPKYPHCEEKMVIITTKSVSRYRGQEHCLHPKLQSTKR FIKWYNAWNEKRRVYEE" Antibacterial||Antifungal ; Escherichia coli ( MEC = 0.32 uM )||Staphylococcus coagulase-negative spp. ( MEC = 1.02 uM )||Staphylococcus aureus ( MEC = 5.17 uM )||Propionibacterium spp. ( MEC = 1.16 uM )||Candida albicans ( MEC = 0.56 uM )||Anti-Gram+ & Gram-||Antifungal||candidacidal||Chemotactic||Anti-inflammatory||No MICs found in DRAMP database Homo sapiens [Human]|||skin, Homo sapiens|||Homo sapiens N/A Hemolytic Activities of Novel Chassatides—The hemolytic effects ofchassatides were evaluated on human type A erythrocytes. Melittin and kalata B1 were used as positive controls. Their HD50 ranged from 11.6 to 51.9 ␮M (Table 2) and were significantly less potent than melittin (2.1 ␮M). Similar to the cytotoxic effect, the three uncyclotides, chassatide C7, C8, and C11, were the most active peptides with HD50 of11.6, 25.5, and 13.3␮M, respectively. Chassatide C1/C4was the least hemolytic with HD50 value of 51.9␮M. Hemolytic activities of chassatides C2, C2A, C10, and C11A were not determined due to insufficient samples obtained and their low toxicities to red blood cells with HD50 ⬎26 ␮M.|||No hemolysis information or data found in the reference(s) presented in this entry 19109182|||J Immunol. 2009 Jan 1;182(1):507-14. PubMed|||J Immunol. 2009 Jan 1;182(1):507-514. 77 FPDB15090 Big defensin|||DRAMP02936|||AP01238|||DRAMP02936|||AP01238 "NPLIPAIYIGATVGPSVWAYLVALVGAAAVTAANIRRASSDNHSCAGNRGWCRSKCFRHE YVDTYYSAVCGRYFCCRSR" Antibacterial||Antifungal ; C.albicans||Antimicrobial||Antifungal||Anti-Gram+||Anti-Gram-||active against Gram+ and Gram- bacteria as well as fungi such as C. albicans.||Anti-Gram+ & Gram-||candidacidal Tachypleus tridentatus [Japanese horseshoe crab]|||Tachypleus tridentatus (Japanese horseshoe crab)|||hemocytes, Tachypleus tridentatus|||Tachypleus tridentatus (Japanese horseshoe crab)|||hemocytes, Tachypleus tridentatus Combine helix and strand structure||Combine Helix and Beta structure N/A 8586631|||J Biochem. 1995 May;117(5):1131-1137.|||J Biochem. 1995 May;117(5):1131-7. PubMed|||J Biochem. 1995 May;117(5):1131-1137.Biochemistry. 2008 Oct 7;47(40):10611-9.|||J Biochem. 1995 May;117(5):1131-7. PubMed 79 FPDB15189 ALFPm3|||AP02146 "QGWEAVAAAVASKIVGLWRNEKTELLGHECKFTVKPYLKRFQVYYKGRMWCPGWTAIRGE ASTRSQSGVA GKTAKDFVRKAFQKGLISQQEANQWLS" Antibacterial ; E. coli||Vibrio vulnificus||Vibrio parahaemolyticus||Vibrio alginolyticus||Streptococcus agalactiae||Staphylococcus aureus||Bacillus sp T2||Anti-Gram+ & Gram-||Antiviral||Antifungal Penaeus monodon [Giant tiger prawn]|||the black tiger shrimp, Penaeus monodon Combine Helix and Beta structure N/A 33922554|||Dev Comp Immunol. 2005;29(10):841-51.Pub-Med. 97 FPDB15447 AP02065|||DRAMP00382|||Datucin|||AP02065|||DRAMP00382 TFPKCAPTRPPGPKPCDINNFKSKFWHIWRA Antifungal||candidacidal||Antibiofilm||Antimicrobial||Anti-Candida albicans, activity value is MIC = 1 uM||The peptide potently inhibits a clinical multidrug-resistant strain C. albicans in both the planktonic and biofilm forms (MIC and MBEC 1-2 uM). Datura stramonium, India, Asia|||Datura stramonium|||Datura stramonium [Jimsonweed]|||Datura stramonium, India, Asia|||Datura stramonium N/A N/A "Biopolymers 2012; 98(4):332-7. Abstract.|||Biopolymers 2012; 98(4):332-337.|||23193597|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 19.|||Biopolymers 2012; 98(4):332-337." 31 FPDB15450 AP03424 RGDILKRWAGHFSKLL Antifungal||candidacidal||Antibiofilm||Anti-5 C. albicans clinical resistant strains, activity value is MIC = 26.4 Philomycus bilineatus Helix "The core data related to the hemolytic activity of Phibilin in the document are as follows, with the test subjects being mouse red blood cells: At a concentration of 400 µg/ml, Phibilin only caused slight hemolysis, with a hemolysis rate of about 2%. No specific hemolysis rate is mentioned for concentrations below 400 µg/ml (such as MIC or MFC-related concentrations), but based on the description of ""low hemolytic activity"" and the 2% hemolysis rate at 400 µg/ml, it can be inferred that the hemolysis rate at lower concentrations is even lower (well below 2%).|||not hemo.lytic till 400 ug/ml." Front Microbiol. 2022 May 11;13:862834. doi: 10.3389/fmicb.2022.862834. PubMed|||Front Microbiol. 2022 May 11;13:862834. doi: 10.3389/fmicb.2022.862834. PubMed 16 FPDB15451 AP03624 VRVGPCDQVCSRTNPEKDECCRAHGHSGHSSCYGGRMNCYG Antifungal||candidacidal||Antibiofilm||Anti-C. albicans ATCC 10231 and clinical strains, activity value is MIC = 5.4 Chinese Medicinal Beetle, Blaps rhynchopetera, China, Asia|||Chinese Medicinal Beetle, Blaps rhynchopetera, China, Asia Bridge little hemo.lytic till 56.25 uM but almost 50% lysis at 112.5 uM (HC50 >100 uM). Microbiol Spectr. 2023 May 4:e0308922. doi: 10.1128/spectrum.03089-22. PubMed|||Microbiol Spectr. 2023 May 4:e0308922. doi: 10.1128/spectrum.03089-22. PubMed 41 FPDB15452 AP03705 YPAKPEAPGEDASPEELSRYYASLRHYLNLVTRQRY Antifungal||candidacidal||Antibiofilm||Remarkably||it displayed selective antifungal activity against virulent C. albicans hyphae-but not the yeast form. gut epithelial paneth cells (PC), Mus musculus|||gut epithelial paneth cells (PC), Mus musculus N/A N/A Science. 2023 Aug 4;381(6657):502-508. doi: 10.1126/science.abq3178. Pub-Med.|||Science. 2023 Aug 4;381(6657):502-508. doi: 10.1126/science.abq3178. Pub-Med. 36 FPDB15453 AP04038 RALRKALKAWRKLAKKLQ Antifungal||candidacidal||Synergistic AMPs||Antibiofilm||Anti-C. gattii AFLP4, activity value is MIC = 5 uM||Anti-C. guilliermondii ATCC 6260, activity value is MIC = 2.5 uM||Anti-C. tropicalis ATCC 750, activity value is MIC = 5 uM||Anti-C. utilis ATCC 9950, activity value is MIC = 5 uM||activity value is MIC = 2.5 uM||Anti-C. parapsilosis ATCC 2209, activity value is MIC = 10 uM||Anti-C. albicans MYA 2876, activity value is MIC = 2.5 uM||Anti-C. krusei ATCC 6258, activity value is MIC = 30 uM||Anti-and C-glabrata ATCC 1707 or ATCC 90030, activity value is MIC > 40 uM Computer-made peptide, designed N/A N/A Arch Biochem Biophys. 2024 Jan 11:109884. doi: 10.1016/j.abb.2024.109884. PubMed|||Arch Biochem Biophys. 2024 Jan 11:109884. doi: 10.1016/j.abb.2024.109884. PubMed 18 FPDB15455 AP04505 VAGQLALWAVQC Antifungal||candidacidal||Antibiofilm||active against C. albicans and C. neoformans based on the survival of the infected animal model:Caenorhabditis elegans. sequence truncation, bacteria-derived, natural derivative N/A N/A Nat Commun. 2022 Oct 13;13(1):6047. doi: 10.1038/s41467-022-33613-1. PubMed|||Nat Commun. 2022 Oct 13;13(1):6047. doi: 10.1038/s41467-022-33613-1. PubMed 12 FPDB15456 AP04508 VVLALWAVQC Antifungal||candidacidal||Antibiofilm||active against C. albicans and C. gattii based on the survival of the infected animal model:Caenorhabditis elegans. bacteria-derived, natural derivative N/A N/A mBio. 2024 May 8;15(5):e0057024. doi: 10.1128/mbio.00570-24. PubMed|||mBio. 2024 May 8;15(5):e0057024. doi: 10.1128/mbio.00570-24. PubMed 10 FPDB15457 AP04509 GQLVVWALQC Antifungal||candidacidal||Antibiofilm||active against C. albicans and C. gattii based on the survival of the infected animal model:Caenorhabditis elegans. bacteria-derived, natural derivative N/A N/A mBio. 2024 May 8;15(5):e0057024. doi: 10.1128/mbio.00570-24. PubMed|||mBio. 2024 May 8;15(5):e0057024. doi: 10.1128/mbio.00570-24. PubMed 10 FPDB15458 AP04510 LVLAFWAVVC Antifungal||candidacidal||Antibiofilm||active against C. albicans and C. gattii based on the survival of the infected animal model:Caenorhabditis elegans. bacteria-derived, natural derivative N/A N/A mBio. 2024 May 8;15(5):e0057024. doi: 10.1128/mbio.00570-24. PubMed|||mBio. 2024 May 8;15(5):e0057024. doi: 10.1128/mbio.00570-24. PubMed 10 FPDB15459 AP04511 VQLALWAVQC Antifungal||candidacidal||Antibiofilm||active against C. albicans and C. gattii based on the survival of the infected animal model:Caenorhabditis elegans. P4 appeared to be better than other Px peptides in the series in protecting the animals from C. gattii infection. bacteria-derived, natural derivative N/A N/A mBio. 2024 May 8;15(5):e0057024. doi: 10.1128/mbio.00570-24. PubMed|||mBio. 2024 May 8;15(5):e0057024. doi: 10.1128/mbio.00570-24. PubMed 10 FPDB15460 AP04512 VLLALWALVC Antifungal||candidacidal||Antibiofilm||active against C. albicans and C. gattii based on the survival of the infected animal model:Caenorhabditis elegans. bacteria-derived, natural derivative N/A N/A mBio. 2024 May 8;15(5):e0057024. doi: 10.1128/mbio.00570-24. PubMed|||mBio. 2024 May 8;15(5):e0057024. doi: 10.1128/mbio.00570-24. PubMed 10 FPDB15474 DRAMP00384|||Cc-GRP|||AP02183|||DRAMP00384|||AP02183 GNEGGGHGGHGGYGGYHHHGGGGGGYGGYHGGGGS Anti-Candida albicans, activity value is MIC = 90 ug/ml||Anti-Candida tropicalis, activity value is MIC = 180 ug/ml||Anti-Colletotrichum lindemuthianum, activity value is MIC = 90 ug/ml||Anti-Fusarium oxysporium, activity value is MIC = 90 ug/ml||Antifungal Coffea canephora|||Coffea canephora [Robusta coffee]|||seeds, Coffea canephora|||Coffea canephora|||seeds, Coffea canephora Rich N/A "Biochim Biophys Acta. 2013 Mar 15.[Epub ahead of print]|||23500079|||Biochim Biophys Acta . 2013 Jun;1830(6):3509-16. doi: 10.1016/j.bbagen.2013.03.007. Epub 2013 Mar 15.|||Biochim Biophys Acta. 2013 Mar 15;1830(6):3509-3516. Pub-Med." 35 FPDB15475 DRAMP00416|||AP01684|||DRAMP00416|||AP01684 KLCERSSGTWSGVCGNNNACKNQCIRLEGAQHGSCNYVFPAHKCICYFPC Anti-Alternaria brassicicola, activity value is MIC = 2 ug/ml||Anti-Botrytis cinerea, activity value is MIC = 2 ug/ml||Anti-Fusarium culmorum, activity value is MIC = 2 ug/ml||Anti-fungi A. brassicola, activity value is IC50 = 2 ug/ml||Anti-B. cinerea, activity value is IC50 = 2 ug/ml||Anti-and F. culmorum, activity value is IC50 = 2 ug/ml||Antifungal Raphanus sativus (Radish) & Brassica napus (Rape)|||radish, Raphanus sativus|||Raphanus sativus (Radish) & Brassica napus (Rape)|||radish, Raphanus sativus Bridge N/A Plant Cell. 1995 May;7(5):573-588.|||8422949|||Plant Cell. 1995 May;7(5):573-88|||Plant Cell. 1995 May;7(5):573-88 50 FPDB15477 DRAMP00425|||Tn-AFP 1|||AP01803|||DRAMP00425|||AP01803 LMCTHPLDCSN Anti-Candida tropicalis, activity value is MIC = 32 ug/ml||Antifungal ; N.A||Antifungal Trapa natans|||fruits, Trapa natans|||Trapa natans|||fruits, Trapa natans N/A Tn-AFP1 has no adverse effect on red blood cells at concentration of 32 ug mL−1 Peptides. 2011 Aug;32(8):1741-1747.|||21736910|||https://pubmed.ncbi.nlm.nih.gov/21736910|||Peptides. 2011 Aug;32(8):1741-7|||Peptides. 2011 Aug;32(8):1741-7 11 FPDB15478 DRAMP00436|||AP00483|||DRAMP00436|||AP00483 KTCEHLADTYRGVCFTNASCDDHCKNKAHLISGTCHNWKCFCTQNC Anti-Aspergillus niger, activity value is MIC = 12.1 ug/ml||Anti-Aspergillus versicolor, activity value is MIC < 5 ug/ml||Anti-Fusarium moniliforme, activity value is MIC = 21.7 ug/ml||Anti-Fusarium oxysporum, activity value is MIC > 100 ug/ml||Anti-Fusarium solani, activity value is MIC = 12.1 ug/ml||Anti-Neurospora crassa, activity value is MIC = 0.04 ug/ml||Anti-Saccharomyces cerevisae, activity value is MIC > 100 ug/ml||Anti-Trichophyton mentagrophytes, activity value is MIC > 100 ug/ml||Anti-Fusarium moniliforme, activity value is MIC = 33.2 ug/ml||Anti-Fusarium oxysporum, activity value is MIC = 100 ug/ml||Anti-Fusarium solani, activity value is MIC = 79.2 ug/ml||Anti-Neurospora crassa, activity value is MIC = 0.05 ug/ml||Anti-N. crassa, activity value is IC50 = 0.04||Antifungal||candidacidal Pisum sativum (Garden pea)|||Pea seeds, Pisum sativvm|||Pisum sativum (Garden pea)|||Pea seeds, Pisum sativvm Combine helix and strand structure||Combine Helix and Beta structure N/A Arch Biochem Biophys. 2000 Jun 15;378(2):278-286.|||10860545|||Arch Biochem Biophys. 2000 Jun 15;378(2):278-86|||Arch Biochem Biophys. 2000 Jun 15;378(2):278-86 46 FPDB15479 DRAMP00437|||AP01686|||DRAMP00437|||AP01686 KTCENLSGTFKGPCIPDGNCNKHCRNNEHLLSGRCRDDFRCWCTNRC Anti-lus niger, activity value is MIC = 10.2 ug/ml||Anti-Aspergillus versicolor, activity value is MIC = 0.34 ug/ml||Anti-Fusarium moniliforme, activity value is MIC = 10 ug/ml||Anti-Fusarium oxysporum, activity value is MIC > 100 ug/ml||Anti-Fusarium solani, activity value is MIC = 8.5 ug/ml||Anti-Neurospora crassa, activity value is MIC < 0.5 ug/ml||Anti-Saccharomyces cerevisae, activity value is MIC > 100 ug/ml||Anti-Trichophyton mentagrophytes, activity value is MIC < 100 ug/ml||Anti-Aspergillus versicolor, activity value is MIC = 5.9 ug/ml||Anti-Fusarium moniliforme, activity value is MIC = 25 ug/ml||Anti-Fusarium solani, activity value is MIC = 5 ug/ml||Anti-Aspergillus niger, activity value is MIC = 10.2 ug/ml||Antifungal Pisum sativum (Garden pea)|||pea seeds, Pisum sativum|||Pisum sativum (Garden pea)|||pea seeds, Pisum sativum Bridge||Combine Helix and Beta structure N/A 10860545|||Arch Biochem Biophys. 2000 Jun 15;378(2):278-86|||Arch Biochem Biophys. 2000 Jun 15;378(2):278-86 47 FPDB15483 DRAMP1061|||DRAMP01061|||Cm-p1|||AP02305|||DRAMP01061|||AP02305 SRSELIVHQR Anti-Botrytis cinerea, activity value is MIC = 20 uM||Anti-Fusarium oxysporum, activity value is MIC = 20 uM||Anti-Aspergillus niger, activity value is MIC = 41 uM||Anti-Candida albicans 01U, activity value is MIC = 13 uM||Anti-C. albicans 38U, activity value is MIC = 7 uM||Anti-C. parapsilosis, activity value is MIC = 105 uM||Anti-C. neoformans strain L26, activity value is MIC = 209 uM||Anti-C. neoformans strain L30, activity value is MIC = 209 uM||Anti-Trichophyton rubrum, activity value is MIC = 3 uM||Anti-Candida albicans, activity value is MIC = 64 ug/ml||Anti-Candida albicans, activity value is MIC = 32 ug/ml||Anti-Candida parapsilosis, activity value is MIC = 256 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 128 ug/ml||Anti-Trichophyton rubrum, activity value is MIC = 32 ug/ml||Anti-B. cinerea, activity value is MIC = 20 uM||Anti-F. oxysporum, activity value is MIC = 20 uM||Anti-A. niger, activity value is MIC = 41 uM||Anti-C. albicans 01U or 38U, activity value is MIC = 7||Anti-C.parapsilosis, activity value is MIC = 105 uM||Anti-C.neoformans, activity value is MIC = 209 uM||Anti-and T. rubrum, activity value is MIC = 3 uM||Antifungal||candidacidal Cenchritis muricatus (Beaded periwinkle)|||Cenchritis muricatus|||marine snail Cenchritis muricatus|||Cenchritis muricatus (Beaded periwinkle)|||marine snail Cenchritis muricatus Helix [Ref.22210491] At the highest evaluated dose (256 ug/ml), Cm-p1 showed no signs of toxicity against human red blood cells.|||The LD50 value is determined as the average concentration of the peptide that produces 50% hemolysis.|||[Ref.22210491] At the highest evaluated dose (256 ug/ml), Cm-p1 showed no signs of toxicity against human red blood cells.|||not hemo.lytic "Biochimie. 2012 Apr;94(4):968-974.|||22210491|||https://pubmed.ncbi.nlm.nih.gov/25921828|||Biochimie . 2012 Apr;94(4):968-74. doi: 10.1016/j.biochi.2011.12.016. Epub 2011 Dec 24.|||Biochimie. 2012 Apr;94(4):968-74.Pub-Med" 10 FPDB15494 DRAMP02439|||U-theraphotoxin-Aju1a|||AP02161|||AP02161 FTCAISCDIKVNGKPCKGSGEKKCSGGWSCKFNVCVKV Anti-C. albicans IOC 45588, activity value is MIC = 2.5||Anti-C. krusei IOC 4559, activity value is MIC = 2.5||Anti-C. glabrata IOC 45658, activity value is MIC = 2.5||Anti-C. parapsilosis IOC 456416, activity value is MIC = 2.5||Anti-C. tropicalis IOC 45608, activity value is MIC = 2.5||Anti-C. guilliermondii IOC 455716, activity value is MIC = 2.5||Anti-Aspergilus niger, activity value is MIC = 5||Anti-Candida albicans MDM8, activity value is MIC = 2.5||Anti-Candida krusei IOC 4559, activity value is MIC = 2.5||Anti-Candida glabrata IOC 45658, activity value is MIC = 2.5||Anti-Candida albicans IOC 45588, activity value is MIC = 2.5||Anti-Candida parapsilosis IOC 456416, activity value is MIC = 2.5||Anti-Candida tropicalis IOC 45608, activity value is MIC = 2.5||Anti-Candida guilliermondii IOC 455716, activity value is MIC = 2.5||Anti-C. albicans, activity value is MIC = 2||Anti-A. niger, activity value is MIC = 10 uM||Antifungal||candidacidal Avicularia juruensis (Yellow-banded pinktoe)|||Avicularia juruensis [Yellow-banded pinktoe]|||venom, the Amazonian Pink Toe spider, Avicularia juruensis, South America|||venom, the Amazonian Pink Toe spider, Avicularia juruensis, South America Bridge The haemolytic activity of the protein was tested using human erythrocytes. A 2.5% (v/v) suspension of washed erythrocytes in PBS was incubated with Juruin ranging from 0.125 to 10uMin a 96-well plate for 3 h with intermittent shaking. The absorbance in the supernatant was measured at 415nm. Haemolysis caused by PBS and 1% (v/v) Triton X-100 were used as 0% and 100% controls, respectively.|||NO hemolysis at 10 uM. "Front. Microbiol. 2012 Sep;3:324-324.|||22973266|||Front Microbiol . 2012 Sep 10:3:324. doi: 10.3389/fmicb.2012.00324. eCollection 2012.|||Front Microbiol. 2012;3:324.Pub-Med." 38 FPDB15507 DRAMP03493|||AP00031|||AP00031 DKLIGSCVWGAVNYTSDCNGECKRRGYKGGHCGSFANVNCWCET Anti-Neurospora crassa, activity value is MIC = 0.1||Anti-Fusarium culmorum, activity value is MIC = 0.2||Anti-Fusarium oxysporum, activity value is MIC = 1.5||Anti-Nectria haematococca, activity value is MIC = 0.4||Anti-Aspergillus fumigatus, activity value is MIC = 6||Anti-Trichoderma viride, activity value is MIC = 1.5||Anti-Candida albicans, activity value is MIC = 2.5||Anti-Cryptococcus neoformans, activity value is MIC = 2.5||Active against C. albicans and P. pastoris.||Antifungal||candidacidal Heliothis virescens (Tobacco budworm moth)|||tobacco budworm, Heliothis virescens|||tobacco budworm, Heliothis virescens Combine helix and strand structure||Combine Helix and Beta structure N/A Biochemistry. 2001 Oct 9;40(40):11995-2003.|||Biochemistry 2001; 40: 11995. doi: 10.1021/bi0103563.|||Biochemistry 2001; 40: 11995. PubMed. 44 FPDB15603 DRAMP00415|||AP00287|||DRAMP00415|||AP00287 QKLCQRPSGTWSGVCGNNNACKNQCIRLEKARHGSCNYVFPAHKCICYFPC Antimicrobial||Antifungal||Anti-A. brassicola, activity value is IC50 = 2 ug/ml||Anti-B. cinerea, activity value is IC50 = 2 ug/ml||Anti-F. culmorum, activity value is IC50 = 2 ug/ml||Anti-F. oxysporum f.sp. lycopersici, activity value is IC50 = 2 ug/ml||Anti-P. oryzae, activity value is IC50 = 0.4 ug/ml||Anti-and V. dahliae, activity value is IC50 = 1.5 ug/ml||candidacidal Raphanus sativus (Radish)|||radish seeds, Raphanus sativus, Brassicaceae species|||Raphanus sativus (Radish)|||radish seeds, Raphanus sativus, Brassicaceae species Bridge N/A Plant Cell. 1995 May;7(5):573-588.|||FEBS Lett. 1993; 316: 233-240|||Plant Cell. 1995 May;7(5):573-588.|||FEBS Lett. 1993; 316: 233-240 51 FPDB15604 DRAMP00418|||AP01819|||DRAMP00418|||AP01819 QKLCERPSGTWSGVCGNNGACRNQCIRLERARHGSCNYVFPAHKCICYFPC Antimicrobial||Antifungal Heliophila coronopifolia (South African Brassicaceae species)|||Heliophila coronopifolia, South Africa|||Heliophila coronopifolia (South African Brassicaceae species)|||Heliophila coronopifolia, South Africa Bridge N/A "BMC Res Notes. 2011 Oct 28;4:459.|||BMC Res Notes . 2011 Oct 28:4:459. doi: 10.1186/1756-0500-4-459.|||BMC Res Notes. 2011 Oct 28;4:459.|||BMC Res Notes. 2011 Oct 28;4(1):459. PubMed." 51 FPDB15605 DRAMP00419|||AP01818|||DRAMP00419|||AP01818 RYCERSSGTWSGVCGNTDKCSSQCQRLEGAAHGSCNYVFPAHKCICYYPC Antimicrobial||Antifungal Heliophila coronopifolia (South African Brassicaceae species)|||Heliophila coronopifolia, South Africa|||Heliophila coronopifolia (South African Brassicaceae species)|||Heliophila coronopifolia, South Africa Bridge N/A "BMC Res Notes. 2011 Oct 28;4:459.|||BMC Res Notes . 2011 Oct 28:4:459. doi: 10.1186/1756-0500-4-459.|||BMC Res Notes. 2011 Oct 28;4:459.|||BMC Res Notes. 2011 Oct 28;4(1):459. PubMed." 50 FPDB15606 DRAMP00420|||AP01817|||DRAMP00420|||AP01817 QKLCERPSGTWSGVCGNNNACRNQCINLEKARHGSCNYVFPAHKCICYFPC Antimicrobial||Antifungal Heliophila coronopifolia (South African Brassicaceae species)|||Heliophila coronopifolia, South Africa|||Heliophila coronopifolia (South African Brassicaceae species)|||Heliophila coronopifolia, South Africa Bridge N/A "BMC Res Notes. 2011 Oct 28;4:459.|||BMC Res Notes . 2011 Oct 28:4:459. doi: 10.1186/1756-0500-4-459.|||BMC Res Notes. 2011 Oct 28;4:459.|||BMC Res Notes. 2011 Oct 28;4(1):459. PubMed." 51 FPDB15607 DRAMP00421|||AP01816|||DRAMP00421|||AP01816 RYCERSSGTWSGVCGNSGKCSNQCQRLEGAAHGSCNYVFPAHKCICYYPC Antimicrobial||Antifungal Heliophila coronopifolia (South African Brassicaceae species)|||Heliophila coronopifolia, South Africa|||Heliophila coronopifolia (South African Brassicaceae species)|||Heliophila coronopifolia, South Africa Bridge N/A "BMC Res Notes. 2011 Oct 28;4:459.|||Dev Comp Immunol . 2012 May;37(1):207-11. doi: 10.1016/j.dci.2011.10.004. Epub 2011 Oct 19.|||BMC Res Notes. 2011 Oct 28;4:459.|||BMC Res Notes. 2011 Oct 28;4(1):459. PubMed." 50 FPDB15619 DRAMP00440|||AP01683|||DRAMP00440|||AP01683 NEMGGPLVVEARTCESQSHKFKGTCLSDTNCANVCHSERFSGGKCRGFRRRCFCTTHC Antimicrobial||Antifungal Helianthus annuus (Common sunflower)|||flowers, common sunflower, Helianthus annuus|||Helianthus annuus (Common sunflower)|||flowers, common sunflower, Helianthus annuus Bridge N/A Plant Physiol. Biochem. 2000;38:253-258.|||Plant Physiol. Biochem. 2000; 38:253-258|||Plant Physiol. Biochem. 2000;38:253-258.|||Plant Physiol. Biochem. 2000; 38:253-258 58 FPDB15924 DRAMP00932|||AP02066|||DRAMP00932|||AP02066 SYFSAWAGPGCNNHNARYSKCGCSNIGHNVHGGYEFVYQGQTAAAYNTDNCKGVAQTRFSSSVNQACSNFGWKSVFIQC Antimicrobial||Antibacterial||Antifungal||Application of Pm-AMP1 resulted in visible hyphal growth inhibition of C. ribicola||P. sulphurascens||O. montium||and O. clavigerum 72-288 h post-treatment. Pm-AMP1 also inhibited spore germination of several other phytopathogenic fungi by 32%-84% 120 h post-treatment (Can J Microbiol. 2011). It confers resistance to multiple fungal pathogens in canola (Brassica napus) (Plant Mol Biol. 2012). Pinus monticola (Western white pine) (Strobus monticola)|||western white pine (WWP), Pinus monitcola|||Viola cotyledon (Violeta)|||western white pine (WWP), Pinus monitcola Bridge N/A "Phytopathology. 2006 Feb;96(2):164-170.|||Peptides . 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 19.|||Anal Biochem. 2003 Jul 1;318(1):107-117.|||Phytopathology. 2006 Feb;96(2):164-70. Pub-Med." 79 FPDB15935 DRAMP00990|||AP01772|||DRAMP00990|||AP01772 KICERASGTWKGICIHSNDCNNQCVKWENAGSGSCHYQFPNYMCFCYFDC Antimicrobial||Antifungal||Anti-their antifungal activity was tested together. Active against B. sorokiniana, activity value is IC50 = 0.5 uM||Anti-F. oxysporum, activity value is IC50 = 0.35 uM||Anti-F. graminearum, activity value is IC50 = 0.52 uM||Anti-B. cinerea, activity value is IC50 = 1 uM||Anti-Ph. betae, activity value is IC50 = 0.52 uM||Anti-and P. debaryanum, activity value is IC50 = 0.5 uM Stellaria media L (Common chickweed seeds)|||seeds, common chickweed, Stellaria media L|||Stellaria media L (Common chickweed seeds)|||seeds, common chickweed, Stellaria media L N/A N/A Biochimie. 2011 Mar;93(3):450-456.|||Biochimie. 2011 Mar;93(3):450-6|||Biochimie. 2011 Mar;93(3):450-456.|||Biochimie. 2011 Mar;93(3):450-6 50 FPDB15937 DRAMP00992|||AP01773|||DRAMP00992|||AP01773 KICERASGTWKGICIHSNDCNNQCVKWENAGSGSCHYQFPNYMCFCYFNC Antimicrobial||Antifungal||Anti-their antifungal activity was tested together. Active against B. sorokiniana, activity value is IC50 = 0.5 uM||Anti-F. oxysporum, activity value is IC50 = 0.35 uM||Anti-F. graminearum, activity value is IC50 = 0.52 uM||Anti-B. cinerea, activity value is IC50 = 1 uM||Anti-Ph. betae, activity value is IC50 = 0.52 uM||Anti-and P. debaryanum, activity value is IC50 = 0.5 uM Stellaria media L (Common chickweed seeds)|||seeds, common chickweed, Stellaria media L|||Stellaria media L (Common chickweed seeds)|||seeds, common chickweed, Stellaria media L N/A N/A Biochimie. 2011 Mar;93(3):450-456.|||Biochimie. 2011 Mar;93(3):450-6|||Biochimie. 2011 Mar;93(3):450-456.|||Biochimie. 2011 Mar;93(3):450-6 50 FPDB15947 DRAMP01013|||PvD1|||AP01677|||DRAMP01013|||AP01677 KTCENLADTYKGPCFTTGSCD Antimicrobial||Antifungal||Antifungal ; Candida albicans||Candida parapsilosis||Candida tropicalis||Candida guilliermondii||Kluyveromyces marxiannus||Saccharomyces cerevisiae||Fusarium oxysporum||Fusarium solani||Fusarium lateritium||Rizoctonia solani||candidacidal Phaseolus vulgaris (Seeds)|||seeds, Phaseolus vulgaris (cv. Pérola)|||Vigna radiata|||seeds, Phaseolus vulgaris (cv. Pérola) Bridge N/A Peptides. 2008 Dec;29(12):2090-2100.|||18786582|||Peptides. 2008 Dec;29(12):2090-100. Epub 2008 Aug 22|||Peptides. 2008 Dec;29(12):2090-2100.|||Peptides. 2008 Dec;29(12):2090-100. Epub 2008 Aug 22 21 FPDB15948 DRAMP01027|||AP02036|||DRAMP01027|||AP02036 RQRDPQQQYEQCQKHCQRRETEPRHMQTCQQRCERRYEKEKRKQQKRYEEQQREDEEKYEERMKEEDN Antimicrobial||Antifungal||Anti-A. helianthi, activity value is IC50 = 5||Anti-C. paradoxa, activity value is IC50 = 20||Anti-C. nicotianae, activity value is IC50 = 5||Anti-C. elegans, activity value is IC50 = 2||Anti-F. oxysporum, activity value is IC50 = 10 ug/ml||Anti-L. maculans, activity value is IC50 = 25 ug/ml||Anti-S. sclerotiorum, activity value is IC50 = 20||Anti-V. dahliae, activity value is IC50 = 5||Anti-S. cerevisiae, activity value is IC50 = 20||Anti-P. cryptogea, activity value is IC50 = 5||Anti-P. parasitica nicotianae, activity value is IC50 = 10||Anti-C. michiganensis, activity value is IC50 = 50 ug/ml||Anti-R-solanacearum, activity value is IC50 > 50 ug/ml||Anti-and E-coli, activity value is IC50 > 50 ug/ml Macadamia integrifolia (Macadamia nut)|||cotton seeds, Macadamia integrifolia|||Macadamia integrifolia (Macadamia nut)|||cotton seeds, Macadamia integrifolia Rich N/A "Plant J. 1999 Sep;19(6):699-710.|||Plant J . 1999 Sep;19(6):699-710. doi: 10.1046/j.1365-313x.1999.00569.x.|||Plant J. 1999 Sep;19(6):699-710.|||Plant J. 1999 Sep;19(6):699-710. PubMed" 68 FPDB15955 DRAMP01037|||AP02035|||DRAMP01037|||AP02035 DPQTECQQCQRRCRQQESGPRQQQYCQRRCKEICEEEEEYN Antimicrobial||Antibacterial||Anti-Gram+||Antifungal||Active against fungi. Said active but not clear to what bacteria and fungi. Macadamia integrifolia (Macadamia nut)|||cotton seeds, Macadamia integrifolia|||Macadamia integrifolia (Macadamia nut)|||cotton seeds, Macadamia integrifolia N/A N/A "Plant J. 1999 Sep;19(6):699-710.|||Plant J . 1999 Sep;19(6):699-710. doi: 10.1046/j.1365-313x.1999.00569.x.|||Plant J. 1999 Sep;19(6):699-710.|||Plant J. 1999 Sep;19(6):699-710. PubMed" 41 FPDB15963 DRAMP01049|||AP02024|||DRAMP01049|||AP02024 RHRHCFSQSHKFVGACLRESNCENVCKTEGFPSGECKWHGIVSKCHCKRIC Antimicrobial||Antifungal||Anti-fungi such as Active against fungi such as N. crassa, activity value is IC50 = 3.5 uM||Anti-A. niger, activity value is IC50 = 1 uM||Anti-and F-solani, activity value is IC50 > 20 uM Saccharum officinarum (Sugarcane)|||Sugarcane, Saccharum officinarum|||Saccharum officinarum (Sugarcane)|||Sugarcane, Saccharum officinarum Combine helix and strand structure N/A "Plant Mol Biol. 2008 Nov;68(4-5):321-335.|||Plant Mol Biol . 2008 Nov;68(4-5):321-35. doi: 10.1007/s11103-008-9372-y. Epub 2008 Jul 12.|||Plant Mol Biol. 2008 Nov;68(4-5):321-335.|||Plant Mol Biol. 2008 Nov;68(4-5):321-35.PubMed" 51 FPDB15964 DRAMP01050|||AP02023|||DRAMP01050|||AP02023 RYCLSQSHRFKGLCMSSSNCANVCQTENFPGGECKADGATRKCFCKKIC Antimicrobial||Antifungal||Anti-fungi such as N. crassa, activity value is IC50 = 1.5 uM||Anti-A. niger, activity value is IC50 = 2 uM||Anti-and F. solani, activity value is IC50 = 1 uM Saccharum officinarum (Sugarcane)|||Sugarcane, Saccharum officinarum|||Saccharum officinarum (Sugarcane)|||Sugarcane, Saccharum officinarum Combine helix and strand structure N/A "Plant Mol Biol. 2008 Nov;68(4-5):321-335.|||Plant Mol Biol . 2008 Nov;68(4-5):321-35. doi: 10.1007/s11103-008-9372-y. Epub 2008 Jul 12.|||Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.|||Plant Mol Biol. 2008 Nov;68(4-5):321-35.PubMed" 49 FPDB15985 DRAMP01444|||Nigrocin-1|||AP00508|||DRAMP01444|||AP00508 GLLDSIKGMAISAGKGALQNLLKVASCKLDKTC Anti-Micrococcus luteus, activity value is MIC = 2.5 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 10 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 10 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 75 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 22.5 ug/ml||Anti-Proteus mirabilis, activity value is MIC > 200 ug/ml||Anti-Serratia marcescens, activity value is MIC > 200 ug/ml||Anti-Candida albicans, activity value is MIC = 100 ug/ml||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||Antimicrobial||Anti-Gram+||Anti-Gram- Pelophylax nigromaculatus (Black-spotted frog) (Rana nigromaculata) (frog skin active peptide)|||Rana nigromaculata (dark-spotted frog ) [Black-spotted frog]|||Pelophylax chosenica, Previously Pelophylax nigromaculatus (OLD Rana nigromaculata), Korea, Asia|||Pelophylax nigromaculatus (Black-spotted frog) (Rana nigromaculata) (frog skin active peptide)|||Pelophylax nigromaculatus (OLD Rana nigromaculata), Asia N/A Even at a high concentration of 100 ug/ml, the hemolysis rate of Nigrocin 1 on human red blood cells is only 1.1%. FEBS Lett. 2001 Oct 19;507(1):95-100.||Ref.11682065|||11682065|||FEBS Lett 2001 Oct 19;507(1):95-100. Pub-Med.|||FEBS Lett. 2001 Oct 19;507(1):95-100.|||FEBS Lett 2001 Oct 19;507(1):95-100. Pub-Med. 33 FPDB16006 DRAMP01384|||Odorranain-N1|||AP01301|||DRAMP01384|||AP01301 DEKGPKWKR Anti-Candida albicans, activity value is MIC = 35.2 ug/ml||Anti-C. albicans, activity value is MIC = 35.2 ug/ml||Anti-E-coli, activity value is MIC > 50 ug/ml||Anti-S-aureus, activity value is MIC > 50 ug/ml||Anti-B-subtilis, activity value is MIC > 50 ug/ml||Anti-and C. albicans, activity value is MIC = 35.2 ug/ml||Antimicrobial||Antifungal||candidacidal Odorrana grahami (Yunnanfu frog) (Rana grahami)|||Odorrana grahami|||skin, Odorrana grahami, China, Asia|||Odorrana grahami (Yunnanfu frog) (Rana grahami)|||skin, Odorrana grahami, China, Asia N/A N/A Mol Cell Proteomics. 2007 May;6(5):882-894.||Ref.17272268|||https://pubmed.ncbi.nlm.nih.gov/17272268|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.|||Mol Cell Proteomics. 2007 May;6(5):882-894.|||Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med. 9 FPDB16012 DRAMP02435|||AP01562|||DRAMP02435|||AP01562 LSKFGGECSLKHNTCTYLKGGKNHVVNCGSAANKKCKSDRHHCEYDEHHKRVDCQTPV Antimicrobial||Antibacterial||Antifungal||Antiparasitic||candidacidal Penicillium chrysogenum (Penicillium notatum)|||Penicillium chrysogenum RP42C; also found in Penicillium chrysogenum Q176|||Penicillium chrysogenum (Penicillium notatum)|||Penicillium chrysogenum RP42C; also found in Penicillium chrysogenum Q176 Beta N/A Peptides. 2010 Apr;31(4):541-547.|||Peptides. 2010 Apr;31(4):541-7.|||Peptides. 2010 Apr;31(4):541-547.Int J Food Microbiol. 2009 Sep 30;135(1):39-46.|||Peptides. 2010 Apr;31(4):541-7. 58 FPDB16016 DRAMP02613|||Mfa-hst5|||AP01567|||DRAMP02613|||AP01567 DSHEERRQGRHGHHEYGRKFHEKHHSHRGY Antimicrobial||Antifungal Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)|||Macaca fascicularis [Crab-eating macaque]|||Macaca fascicularis|||Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)|||Macaca fascicularis Alpha helix (CD)||Helix N/A Protein Pept Lett. 2010 Jul;17(7):909-918.|||20423320|||Protein Pept Lett. 2010 Jul;17(7):909-18|||Protein Pept Lett. 2010 Jul;17(7):909-918.|||Protein Pept Lett. 2010 Jul;17(7):909-18 30 FPDB16017 DRAMP02623|||Histatin-1|||AP00175|||DRAMP02623|||AP00175 DSHEERHHGRHGHHKYGRKFHEKHHSHRGYRSNYLYDN Antimicrobial||Antibacterial||Antifungal||Active against C. albicans. Updated 7/2021||candidacidal Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)|||Macaca fascicularis [Crab-eating macaque]|||Crab eating macaque, Cynomolgus Monkey, Philippine Monkey and the Long-tailed Macaque, Macaca fascicularis|||Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)|||Crab eating macaque, Cynomolgus Monkey, Philippine Monkey and the Long-tailed Macaque, Macaca fascicularis Rich N/A J Dent Res. 1990 Nov;69(11):1717-1723.|||2229609|||Infect Immun. 1989 Aug;57(8):2405-9. doi: 10.1128/iai.57.8.2405-2409.1989.|||J Dent Res. 1990 Nov;69(11):1717-1723.|||Yamashita T, Saito K. PubMed. 38 FPDB16022 DRAMP18242|||AP02336|||DRAMP18242|||AP02336 EKYTEVPEYV Antimicrobial||Antibacterial||Antifungal||Anti-Gram+||Anti-Gram-||Anti-fungi C. Albicans, activity value is MIC = 15.62 ug/ml||Anti-A. niger, activity value is MIC = 15.62 ug/ml||Anti-S.epidermidis, activity value is MIC = 1000 ug/ml||Anti-and E.coli, activity value is MIC = 1000 ug/ml||candidacidal Bacillus thuringiensis|||Bacillus subtilis strain K1; Bacillus thuringiensis strain SM1|||Gorilla gorilla gorilla (Lowland gorilla)|||Bacillus subtilis strain K1; Bacillus thuringiensis strain SM1 N/A N/A "Front Microbiol. 2013 Nov 21;4:332.|||J Am Soc Mass Spectrom . 2012 Oct;23(10):1716-28. doi: 10.1007/s13361-012-0437-4. Epub 2012 Jul 31.|||Front Microbiol. 2013 Nov 21;4:332.J Am Soc Mass Spectrom. 2012 Oct;23(10):1716-28. Epub 2012 Jul 31.|||J Am Soc Mass Spectrom. 2012 Oct;23(10):1716-28. doi: 10.1007/s13361-012-0437-4. PubMed" 10 FPDB16049 DRAMP03048|||OdVP3|||AP01681|||DRAMP03048|||AP01681 KDLHTVVSAILQAL Antimicrobial||Antibacterial||Antifungal||candidacidal Orancistrocerus drewseni (Solitary wasp)|||Orancistrocerus drewseni [Solitary wasp]|||venom, solitary wasp, Orancistrocerus drewseni (Hymenoptera: Eumenidae), South America|||Orancistrocerus drewseni (Solitary wasp)|||venom, solitary wasp, Orancistrocerus drewseni (Hymenoptera: Eumenidae), South America N/A N/A Toxicon. 2010 Apr 1;55(4):711-718.|||19857508|||Toxicon. 2010 Apr 1;55(4):711-8|||Toxicon. 2010 Apr 1;55(4):711-718.|||Toxicon. 2010 Apr 1;55(4):711-8 14 FPDB16060 DRAMP03258|||Rondonin|||AP02556|||DRAMP03258|||AP02556 IIIQYEGHKH Antimicrobial||Antifungal||Anti-Trichosporon sp IOC 4569, activity value is MIC = 1.1 uM||Anti-Candida albicans MDM8, activity value is MIC = 16.75 uM||Anti-Candida krusei IOC 4559, activity value is MIC = 16.75 uM||Anti-Candida glabrata IOC 4565, activity value is MIC = 8.37 uM||Anti-Candida albicans IOC 4558, activity value is MIC = 8.37 uM||Anti-Candida parapsilosis IOC 4564, activity value is MIC = 16.75 uM||Anti-Candida tropicalis IOC 4560, activity value is MIC = 8.75 uM||Anti-Candida guilliermondii IOC 4557, activity value is MIC = 16.75 uM||Anti-fungi B. bassiana Trichosporon sp IOC4569, activity value is MIC = 1.1 uM||Anti-s C. albicans MDM8 or IOC 4558, activity value is MIC = 8.37||Anti-C. krusei IOC 4559, activity value is MIC = 16.75 uM||Anti-C. glabrata IOC 4565 (MIC, activity value is MIC = 8.37 uM||Anti-C. parapsilosis IOC 4564, activity value is MIC = 16.75 uM||Anti-C. tropicalis IOC 4560, activity value is MIC = 8.75 uM||Anti-and C. guilliermondii IOC 4557, activity value is MIC = 16.75 uM||Antiviral||candidacidal||Synergistic AMPs Acanthoscurria rondoniae (Spider)|||Acanthoscurria rondoniae|||haemolymph, Eurypelma californicum and Acanthoscurria gomesiana;|||Acanthoscurria rondoniae (Spider)|||haemolymph, Eurypelma californicum and Acanthoscurria gomesiana;|||haemolymph, Eurypelma californicum and Acanthoscurria gomesiana; N/A N/A "Results Immunol. 2012;2:66-71.|||http://www.uniprot.org/uniprot/B3EWP8|||Results Immunol . 2012 Apr 2:2:66-71. doi: 10.1016/j.rinim.2012.03.001. eCollection 2012.|||Results Immunol. 2012;2:66-71.|||Results Immunol. 2012 Apr 2;2:66-71. PubMed|||Results Immunol. 2012 Apr 2;2:66-71. PubMed" 10 FPDB16061 DRAMP03322|||Pw2|||AP00190|||DRAMP03322|||AP00190 HPLKQYWWRPSI Antimicrobial||Antifungal||Antiparasitic||Anti-E. acervulina and E. tenella sporozoites . Active against fungi C. albicans, activity value is MIC = 12.5||Anti-S.aureus, activity value is MIC > 125 uM||candidacidal Phage display peptide library|||Synthetic construct|||phage display peptide library, man-made sequences|||Phage display peptide library|||phage display peptide library, man-made sequences Non helix or strand structure||Nonhelixbeta N/A Mol Biochem Parasitol. 2002 Mar;120(1):53-60.|||11849705|||Mol Biochem Parasitol. 2002 Mar;120(1):53-60.||see ref for Pac-525|||Mol Biochem Parasitol. 2002 Mar;120(1):53-60.Biol Chem. 2002 Sep 27;277(39):36351-6.|||Mol Biochem Parasitol. 2002 Mar;120(1):53-60. 12 FPDB16075 DRAMP03576|||Histatin-1|||AP00798|||DRAMP03576|||AP00798 DSHEKRHHGYRRKFHEKHHSHREFPFYGDYGSNYLYDN Antimicrobial||Antifungal||candidacidal||Chemotactic||Wound healing Homo sapiens (Human)|||Homo sapiens [Human]|||human saliva, Homo sapiens|||Homo sapiens (Human)|||human saliva, Homo sapiens Rich N/A J Biol Chem. 1988 Jun 5;263(16):7472-7477|||3286634|||J Biol Chem. 1988 Jun 5;263(16):7472-7|||J Biol Chem. 1988 Jun 5;263(16):7472-7477|||J Biol Chem. 1988 Jun 5;263(16):7472-7 38 FPDB16083 DRAMP03640|||Hcl-hst5|||AP01568|||DRAMP03640|||AP01568 DSHEKRHHEHRRKFHEKHHSHRGY Antimicrobial||Antifungal Nomascus leucogenys|||Nomascus leucogenys [Northern white-cheeked gibbon]|||Nomascus leucogenys Alpha helix (CD)||Helix N/A Protein Pept Lett. 2010 Jul;17(7):909-918.|||20423320|||Protein Pept Lett. 2010 Jul;17(7):909-18|||Protein Pept Lett. 2010 Jul;17(7):909-918.|||Protein Pept Lett. 2010 Jul;17(7):909-18 24 FPDB16132 DRAMP04398|||AP01560|||DRAMP04398|||AP01560 AKYTGKCTKSKNECKYKNDAGKDTFIKCPKFDNKKCTKDNNKCTVDTYNNAVDCD Antimicrobial||Antifungal||Antiviral||inhibited the growth of filamentous fungi: A. flavus (sensitivity +)||A. fumigatus (+++)||A. giganteus (++)||A. nidulans (+++)||A. niger (+++)||A.terreus (-)||B. cinerea (+++)||C. carbonum (++)||F. oxysporum (+)||F.sambucinum (-)||G. roseum (+)||M.circinelloides (-)||M.genevensis (-)||N. crassa (++)||P.chrysogenum Q176 (-)||P. chrysogenum (wild-type) (+)||and T. koningii (+++). Treated with 50 ug PAF/ml: + indicates 31.2-54.9% growth||++ indicates 10.5-12.9% growth; and +++ indicates less than 10% growth 0.5-8.7%. PAF inhibited the growth of a variety of filamentous fungi||including opportunistic human pathogenic and phytopathogenic fungi||whereas bacterial and yeast cells were unaffected. Penicillium chrysogenum (Penicillium notatum)|||Penicillium chrysogenum|||Penicillium chrysogenum (Penicillium notatum)|||Penicillium chrysogenum Beta strand (5 strands; 24 residues)||Beta N/A FEBS J. 2009 May;276(10):2875-2890.|||Arch Microbiol. 2003 Sep;180(3):204-10. PubMed|||FEBS J. 2009 May;276(10):2875-2890.Gene. 1995 Dec 29;167(1-2):167-171.|||Arch Microbiol. 2003 Sep;180(3):204-10. PubMed 55 FPDB16143 DRAMP18406|||AP02773|||AP02773 KEICCKELTKPVKCSSDPLCQKLCMEKEKYEDGHCFTILSKCLCMKRCNAKTLATELLA Antimicrobial||Antifungal||candidacidal Fruits, Capsicum annuum|||Fruits, Capsicum annuum Bridge N/A "BMC Microbiol. 2016 Jan 27;16:12.|||Biopolymers . 2014 Jan;102(1):30-9. doi: 10.1002/bip.22351.|||Biopolymers. 2014 Jan;102(1):30-9. PubMed" 59 FPDB16206 DRAMP29089|||AP03209 AFIQLSKPCISDKECSIVKNYRARCRKGYCVRRRIR Antimicrobial||Antifungal||Anti-Botrytis cinerea, activity value is IC50 = 1.55||Anti-Fusarium graminearum, activity value is IC50 = 1.93||Anti-F.virguliforme, activity value is IC50 = 1.68||Anti-F.oxysporum, activity value is IC50 = 0.52||candidacidal Medicago truncatula (Barrel medic) (Medicago tribuloides)|||symbiont bacteria, legume Medicago truncatula α-helix and β-sheet||Combine Helix and Beta structure No hemolysis information or data found in the reference(s) presented in this entry Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16043-16054. doi: 10.1073/pnas.2003526117. Epub 2020 Jun 22.|||Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16043-16054. doi: 10.1073/pnas.2003526117. Epub 2020 Jun 22.||Ref.32571919|||Biomed Res Int. 2014;2014:320796. doi:10.1155/2014/320796. PubMed 36 FPDB16208 DRAMP29091|||Skh-AMP1|||AP03082|||DRAMP29091|||AP03082 GRTSKQELCTWERGSVRQADKTIAG Anti-Candida albicans ATCC 10231, activity value is MIC = 21.6 uM||Anti-Candida krusei DSM 70079, activity value is MIC = 20.7 uM||Anti-Candida glabrata ATCC 90030, activity value is MIC = 19.8 uM||Anti-Aspergillus niger ATCC 9029, activity value is MIC = 22.5 uM||Anti-Aspergillus flavus PFCC 100, activity value is MIC = 23.4 uM||Anti-Aspergillus fumigatus Af 293, activity value is MIC = 20.7 uM||Anti-C. albicans ATCC 10231, activity value is MIC = 21.6 uM||Anti-C. krusei DSM 70079, activity value is MIC = 20.7 uM||Anti-C. glabrata ATCC 90030, activity value is MIC = 19.8 uM||Anti-A. niger ATCC 9029, activity value is MIC = 22.5 uM||Anti-A. flavus PFCC 100, activity value is MIC = 23.4 uM||Anti-and A. fumigatus Af 293, activity value is MIC = 20.7 uM||activity value is MFC = 43.2 uM||activity value is MFC = 41.4 uM||activity value is MFC = 39.6 uM||activity value is MFC = 45 uM||activity value is MFC = 58.5 uM||Antifungal||candidacidal Satureja khuzistanica|||leaves, Satureja khuzistanica|||Satureja khuzistanica|||leaves, Satureja khuzistanica α-helical Human erythrocytes (0.67% hemolysis at 25.2 uM)|||[Ref.31128493] Using human erythrocytes, the hemolytic activity of Skh-AMP1 at concentrations from 3.6 uM to 72 uM was reported in the range of 0.19%–2.1%. At the MIC concentration of 25.2 uM, a very low hemolytic activity of 0.67% (SD = 0.02) was observed. Also, this peptide at MFC concentrations (36, 54 and 72 uM) showed 0.98%, 1.45% and 2.1% hemolytic activity for human erythrocytes.|||Using human erythrocytes, the hemolytic activity of Skh-AMP1 at concentrations from 3.6uMto72 uM was reported in the range of 0.19%–2.1%. At the MIC concentration of 25.2 uM, a very low hemo lytic activity of 0.67% (SD=0.02) was observed. Also, this peptide at MFC concentrations (36, 54 and 72 uM) showed 0.98%, 1.45% and 2.1% hemolytic activity for human erythrocytes. "Phytochemistry. 2019 Aug;164:136-143. doi: 10.1016/j.phytochem.2019.05.011. Epub 2019 May 23.||Ref.31128493|||31128493|||Phytochemistry . 2019 Aug:164:136-143. doi: 10.1016/j.phytochem.2019.05.011. Epub 2019 May 23.|||Peptides. 2020 Jan;123:170195. doi: 10.1016/j.peptides.2019.170195. Epub 2019 Nov 6.##Phytochemistry. 2019 Aug;164:136-143. doi: 10.1016/j.phytochem.2019.05.011. Epub 2019 May 23.||Ref.31128493|||Phytochemistry. 2019 May 23;164:136-143. doi: 10.1016/j.phytochem.2019.05.011.PubMed" 25 FPDB16568 L-Ctl|||BCtl|||AP02985|||AP02985 RSMRLSFRARGYGFR Antifungal||Anti-Gram-positive M. luteus, activity value is MIC = 0.8 uM||Anti-B. megaterium, activity value is MIC = 0.8 uM||Anti-E. coli D22, activity value is MIC = 8 uM||Anti-Filamentous fungi N. grassa, activity value is MIC = 1.2 uM||Anti-A. fumigatus, activity value is MIC = 10 uM||Anti-N. haematococca, activity value is MIC = 0.2 uM||Anti-F. culmorum, activity value is MIC = 2 uM||Anti-F. oxysporum, activity value is MIC = 6 uM||Anti-T. mentagrophytes, activity value is MIC = 4 uM||Anti-cells C. albicans, activity value is MIC = 1.2 uM||Anti-C. tropicalis, activity value is MIC = 1.8 uM||Anti-C. glabrata, activity value is MIC = 8 uM||Anti-and C. neoformans, activity value is MIC = 1.4 uM||candidacidal Homo sapiens [Humans ]|||Bos taurus [Bovine]|||chromaffin cells and in secretion medium, bovine|||chromaffin cells and in secretion medium, bovine Helix N/A "29915284|||35216181|||Cell Mol Life Sci . 2005 Feb;62(3):377-85. doi: 10.1007/s00018-004-4461-9.||see the ref|||Cell Mol Life Sci. 2005 Feb;62(3):377-85. doi: 10.1007/s00018-004-4461-9. PubMed" 15 FPDB16691 GHH20|||AP01494|||AP01494 GHHPHGHHPHGHHPHGHHHPH Antifungal ; Candida parapsilosis||Candida albicans||Candida glabrata||Candida krusei||Antifungal||candidacidal Homo sapiens Rich N/A 18797515|||PLoS Pathog. 2008 Aug 1;4(8):e1000116|||PLoS Pathog. 2008 Aug 1;4(8):e1000116 21 FPDB16702 Cc-LTP1|||AP01678|||AP01678 ITCQQVTSELGPCVPYLTGQGIP Antifungal ; Candida albicans||Antifungal||candidacidal||Enzyme inhibitor coffee seeds, Coffea canephora N/A N/A 21167915|||Biochim Biophys Acta. 2011 Apr;1810(4):375-83. PubMed.|||Biochim Biophys Acta. 2011 Apr;1810(4):375-83. PubMed. 23 FPDB16704 MCh-AMP1|||AP03056|||AP03056 LSVKAFTGIQLRGVCGIEVKARG Anti-Candida albicans ATCC 10231, activity value is MIC = 6.66||Anti-C. glabrata ATCC 90030, activity value is MIC = 3.33||Anti-C. krusei DSM 70079, activity value is MIC = 6.66||Anti-A. flavus PFCC 100, activity value is MIC = 13.32||Anti-C. albicans ATCC 10231, activity value is MIC = 6.66 uM||Anti-C. glabrata ATCC 90030, activity value is MIC = 3.33 uM||Anti-C. krusei DSM 70079, activity value is MIC = 6.66 uM||Anti-A. flavus PFCC 100, activity value is MIC = 13.32 uM||Anti-A. niger ATCC 9029, activity value is MIC = 6.66 uM||Anti-and A. fumigatus Af293, activity value is MIC = 6.66 uM||Antifungal||candidacidal Matricaria chamomilla L. [German chamomile]|||Matricaria chamomilla L.|||Matricaria chamomilla L. N/A MCh-AMP1 demonstrated 3.65% hemolytic activity at the concentration of 13.32 uM on human, MCh-AMP1 induced 10.6% of hemolytic activity at the highest tested concentration of 105.58 uM, This new peptide demonstrated 3.65% hemolytic activity at the concentration of 13.32 uM.red blood cells and 10% toxicity after 48 h at the same concentration on HEK293 cell lines. Fig. 4c. MCh-AMP1 revealed a negligible hemolytic activity against the tested RBCs within the studied concentration range of MCh-AMP1. MCh-AMP1 demonstrated approximately 11.6% hemolysis at the concentration of 105.5 uM.|||Within the concentration range studied, the hemolytic activity of MCH-AMP1 on the tested red blood cells is negligible. At a concentration of 105.5 μM, the hemolysis rate of MCH-AMP1 is approximately 11.6%.|||As shown in Fig. 4b, MCh-AMP1 induced 10.6% of hemolytic activity at the highest tested concentration of 105.58 uM, which was 2-4 times higher than the MICs for fungal strains. This new peptide demonstrated 3.65% hemolytic activity at the concentration of 13.32 uM. "30773822|||Chem Biol Drug Des . 2019 May;93(5):949-959. doi: 10.1111/cbdd.13500. Epub 2019 Mar 13.|||Chem Biol Drug Des. 2019 May;93(5):949-959. doi: 10.1111/cbdd.13500. PubMed" 23 FPDB16768 HGAPDH|||AP02017|||AP02017 GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA Antibacterial||Antifungal||Active against Gram- bacteria E. coli BL21||P. aeruginosa PAO||P. aeruginosa clinical isolate and C. albicans in micromolar concentrations (data not shown).||candidacidal Homo sapiens [Human]|||placental tissue, Homo sapiens|||placental tissue, Homo sapiens N/A N/A "22832495|||J Invest Dermatol . 2013 Jan;133(1):144-53. doi: 10.1038/jid.2012.254. Epub 2012 Jul 26.|||J Invest Dermatol. 2012 Jul 26. doi: 10.1038/jid.2012.254. PubMed" 31 FPDB16772 Oreoch-3|||AP02140|||AP02140 IWDAIFHGAKHFLHRLVNPGGKDAVKDVQQKQ Antibacterial||Antifungal||Anti-mainly C. albicans and very weakly against B.subtilis, activity value is MIC = 106 uM||Anti-E.tarda, activity value is MIC = 160 uM||Anti-and Vibrio sp, activity value is MIC = 106 uM||candidacidal||anti-sepsis Oreochromis niloticus [Nile tilapia]|||gills, tilapia, Oreochromis niloticus|||gills, tilapia, Oreochromis niloticus N/A "Synthetic piscidin-like peptides were assays for hemolytic activity in human and fish red blood cells. Oreoch-1 and Oreoch-3 were not hemo- lytic forhuman red blood cells at concentrations below55 uM. Incontrast, Oreoch-2 was hemolytic in human erythrocytes reaching 50% ofhemoly- sis at 19 uM(Fig. 7A). In addition, hemolytic activity in fish red blood cells was observed for Oreoch-1 and Oreoch-2 above 16 uMand 7 uMrespec- tively, in a dose-dependent manner. Oreoch-1 and Oreoch-2 reached 23% and 57% ofhemolysis, respectively, at the highest concentration analyzed (Fig. 7B). In contrast, Oreoch-3 was not hemolytic for fish erythrocytes at concentrations below 55 uM(Fig. 8B)." Reference: Acostaa J, Monterob V, Carpioa Y, Velázqueza J, Garayc HE, Reyesc O, Cabralesc A, Masforrolc Y, Moralesa A, Estrada MP (2013) Cloning and functional characterization of three novel antimicrobial peptides from tilapia (Oreochromis niloticus). A|||Aquaculture 2013; 372–375;9–18. Sci Direct.|||Aquaculture 2013; 372–375;9–18. Sci Direct. 32 FPDB16803 MMGP1|||AP02322|||AP02322 MLWSASMRIFASAFSTRGLGTRMLMYCSLPSRCWRK Anti-Candida albicans, activity value is MIC = 0.57 uM||Anti-Aspergillus niger, activity value is MIC = 4.29 uM||Anti-C. albicans, activity value is MIC = 0.57 uM||Antifungal||candidacidal Marine organism|||marine metagenome (species undefined)|||marine metagenome (species undefined) Helix N/A "22670672|||Protein Pept Lett . 2012 Dec;19(12):1289-96. doi: 10.2174/092986612803521620.|||Protein Pept Lett. 2012 Dec;19(12):1289-96.Pub-Med" 36 FPDB16812 Ps-AFP1|||AP03019|||AP03019 RQLKSSRRGALVCVRLKLCSAILSRGLSCGMFSCNARR Antifungal||Anti-A. niger, activity value is EC50 = 15.6 uM||candidacidal Pisum sativum [Garden pea]|||peas radicle, Pisum sativum|||peas radicle, Pisum sativum Bridge N/A "23835303|||Biochimie . 2013 Oct;95(10):1939-48. doi: 10.1016/j.biochi.2013.06.027. Epub 2013 Jul 5.|||Biochimie. 2013 Oct;95(10):1939-48. doi: 10.1016/j.biochi.2013.06.027. PubMed" 38 FPDB16830 AP00056 LLGPVLGLVGSALGGLLKKI Active against E. coli D21 (LC 4.8 uM) and S. aureus Cowan 1(LC 3.3 uM). Active also against Gram- Y. pseudotuberculosis YPIII (LC 8.2 uM)||P. syringae pv tabaci (8.2 uM)||E. agglomerans Bo-1S (11.3 uM)||Gram+ B. megaterium Bm11 (0.8 uM)||S. lentus (0.6 uM)||M. luteus (0.2 uM)||fungi C. albicans ATCC 10231 (1.6 uM)||C. guiller-mondii (0.7 uM)||C. tropicalis (0.6 uM) .||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Hemolytic Yellow-bellied toad, Bombina variegata L, Europe Helix highly Hemolytic (Lethal concentration 14.6 uM) EMBO J. 1993; 12:4829-4832. doi: 10.1002/j.1460-2075.1993.tb06172.x.||Mangoni ML et al. 2007|||EMBO J. 1993; 12:4829-4832. PubMed. 20 FPDB16832 AP00148 ATYNGKCYKKDNICKYKAQSGKTAICKCYVKKCPRDGAKCEFDSYKGKCYC Anti-Filamentous fungi A. fumigatus, activity value is MIC = 1 uM||Anti-A. niger, activity value is MIC = 0.25 uM||Anti-A. terreus, activity value is MIC = 32||Anti-N. crassa, activity value is MIC = 0.06||Anti-T. rubrum, activity value is MIC = 0.25 uM||Anti-s C. albicans and S. cerevisiae, activity value is MIC = 2||Antifungal||candidacidal Aspergillus giganteus Beta N/A Nucleic Acids Res. 1990 Jul 11;18(13):3987. doi: 10.1093/nar/18.13.3987.||Huber et al., 2018|||Nucleic Acids Res. 1990 Jul 11;18(13):3987. Pub-Med 51 FPDB16836 AP00738 YPIKPEAPGEDASPEELNRYYASLRHYLNLVTRQRY Anti-A. simii, activity value is MIC = 15 ug/ml||Anti-and C. neoformans, activity value is MIC = 25 ug/ml||Antifungal||candidacidal Intestine, Homo sapiens Helix The hemolysis rate on human red blood cells is < 5%. FEBS Lett. 1996;380(3):237?240. doi:10.1016/0014-5793(96)00050-6. PubMed 36 FPDB16837 AP00739 GLFDIVGKLLGGLGL Anti-Gram+ & Gram-||Antifungal||candidacidal Skin Secretion, Australian White's Tree Frog, Litoria caerulea, Australia Helix N/A Int J Genomics. 2018;2018:8158453. doi:10.1155/2018/8158453. PubMed. 15 FPDB16841 AP00983 QNNICKTTSKHFKGLCFADSKCRKVCIQEDKFEDGHCSKLQRKCLCTKNC Active against C. albicans . It also inhibited the penetration of C. albicans into the infected cells.||Antifungal||candidacidal Capsicum chinense Bridge N/A Plant Physiol 1998; 120:633||Anaya-López JL et al., 2006|||Plant Physiol 1998; 120:633 50 FPDB16842 AP01163 DKLIGSCVWGAVNYTSNCNAECKRRGYKGGHCGSFANVNCW Antifungal||candidacidal Archaeoprepona demophoon Combine Helix and Beta structure N/A Protein Sci. 2004; 13: 703-713 41 FPDB16846 AP01561 LSKYGGECSVEHNTCTYLKGGKDHIVSCPSAANLRCKTERHHCEYDEHHKTVDCQTPV Anti-It inhibited yeast strains C. albicans, activity value is MIC = 8||Anti-A. fumigatus, activity value is MIC = 4||Anti-F. oxysporum, activity value is MIC = 8||Anti-F. solani, activity value is MIC = 8 uM||Anti-T. beigelii, activity value is MIC = 8||Anti-E-coli, activity value is MIC > 50 uM||Anti-B-subtilis, activity value is MIC > 50 uM||Antifungal Aspergillus niger Bridge N/A Biochem Biophys Res Commun. 1999 Oct 5;263(3):646-51. PubMed 58 FPDB16847 AP01685 QKLCERSSGTWSGVCGNNNACKNQCINLEGARHGSCNYIFPYHRCICY Anti-fungi A. brassicola, activity value is IC50 = 5 ug/ml||Anti-B. cinerea, activity value is IC50 = 9 ug/ml||Anti-and F. culmorum, activity value is IC50 = 11 ug/ml||Antifungal radish, Raphanus sativus Bridge N/A Plant Cell. 1995 May;7(5):573-88 48 FPDB16848 AP01687 QKLCERPSGTWSGVCGNNNACKNQCINLEGARHGSCNYVFPYHRCICYFPC Anti-low salt medium A: active against A. brassicola, activity value is IC50 = 3 ug/ml||Anti-B. cinerea, activity value is IC50 = 1.5 ug/ml||Anti-F. culmorum, activity value is IC50 = 2 ug/ml||Anti-F. oxysporum f.sp. lycopersici, activity value is IC50 = 1.8 ug/ml||Anti-P. oryzae, activity value is IC50 = 0.25 ug/ml||Anti-and V. dahliae, activity value is IC50 = 0.8 ug/ml||FEBS Lett. 1993 Feb 1;316(3):233-40. Pub-Med. Brassica rapa subsp. chinensis Bridge N/A FEBS Lett. 1993 Feb 1;316(3):233-40. Pub-Med. 51 FPDB16849 AP01688 QKLCERPSGTWSGVCGNNNACKNQCIR Anti-low salt medium A: active against A. brassicola, activity value is IC50 = 75 ug/ml||Anti-B.cinerea, activity value is IC50 > 100 ug/ml||Anti-F. culmorum, activity value is IC50 = 38 ug/ml||Anti-F. oxysporum f.sp. lycopersici, activity value is IC50 = 42 ug/ml||Anti-P. oryzae, activity value is IC50 = 3 ug/ml||Anti-and V. dahliae, activity value is IC50 = 15 ug/ml||Antifungal Brassica rapa subsp. chinensis; Brassica napus Bridge N/A FEBS Lett. 1993 Feb 1;316(3):233-40. Pub-Med. 27 FPDB16850 AP01690 QKLCQRPSGTWSGVCGNNNACKNQCINLEKARHGSCNYVFPAHKCICYFPC Anti-low salt medium A: active against A. brassicola, activity value is IC50 = 4.5 ug/ml||Anti-B. cinerea, activity value is IC50 = 3.5 ug/ml||Anti-F. culmorum, activity value is IC50 = 2.3 ug/ml||Anti-F. oxysporum f.sp. lycopersici, activity value is IC50 = 2.3 ug/ml||Anti-P. oryzae, activity value is IC50 = 0.3 ug/ml||Anti-and V. dahliae, activity value is IC50 = 1.2 ug/ml||Antifungal S alba Bridge N/A FEBS Lett. 1993 Feb 1;316(3):233-40. Pub-Med. 51 FPDB16851 AP01691 QKLCERPSGTWSGVCGNNNACKNQCINLEK Anti-low salt medium A: active against A. brassicola, activity value is IC50 = 0.6 ug/ml||Anti-B. cinerea, activity value is IC50 = 2 ug/ml||Anti-F. culmorum, activity value is IC50 = 2.8 ug/ml||Anti-F. oxysporum f.sp. lycopersici, activity value is IC50 = 1.3 ug/ml||Anti-P. oryzae, activity value is IC50 = 0.35 ug/ml||Anti-and V. dahliae, activity value is IC50 = 1.2 ug/ml||Antifungal Brassica napus Bridge N/A FEBS Lett. 1993 Feb 1;316(3):233-40. Pub-Med. 30 FPDB16852 AP01692 KLCERPSGTWSGVCGNSNACKNQCINLEKARHGSCNYVFPAHKCICYFPC Anti-low salt medium A: active against A. brassicola, activity value is IC50 = 10 ug/ml||Anti-B. cinerea, activity value is IC50 = 3.9 ug/ml||Anti-F. culmorum, activity value is IC50 = 3 ug/ml||Anti-F. oxysporum f.sp. lycopersici, activity value is IC50 = 3 ug/ml||Anti-P. oryzae, activity value is IC50 = 0.25 ug/ml||Anti-and V. dahliae, activity value is IC50 = 1.5 ug/ml||Antifungal A thaliana Bridge N/A FEBS Lett. 1993 Feb 1;316(3):233-40. Pub-Med. 50 FPDB16854 AP02037 KRDPQQREYEDCRRRCEQQEPRQQHQCQLRCREQQRQHGRGGDMMNPQRGGSGRYEEGEEEQS active against fungi (e.g.||L. maculans and V. dahliae) at 25 ug/ml.||Antifungal cotton seeds, Macadamia integrifolia N/A N/A "Plant J . 1999 Sep;19(6):699-710. doi: 10.1046/j.1365-313x.1999.00569.x.|||Plant J. 1999 Sep;19(6):699-710. PubMed" 63 FPDB16855 AP02040 KSCCRSTLGRNCYNLCRARGAQKLCAGVCRCKISSGLSCPKGFPK Anti-the peptide showed activity against pathogens of plant origin. Crude active against S. uvarum CC-21, activity value is MIC = 32 ug/ml||Anti-S. uvarum CC-23, activity value is MIC < 4 ug/ml||Anti-S. cerevisiae, activity value is MIC = 8 ug/ml||Antifungal wheat, Triticum aestivum Combine Helix and Beta structure N/A "Appl Microbiol . 1974 Aug;28(2):165-8. doi: 10.1128/am.28.2.165-168.1974.|||Appl Microbiol. 1974 Aug;28(2):165-8. Pub-Med." 45 FPDB16856 AP02245 LEYKGECFTKDNTCKYKIDGKTYLAKCPSAANTKCEKDGNKCTYDSYNRKVKCDFRH Antifungal Neosartorya fischeri Bridge N/A "Peptides . 2011 Aug;32(8):1724-31. doi: 10.1016/j.peptides.2011.06.022. Epub 2011 Jun 30.|||Peptides. 2011 Aug;32(8):1724-31.Pub-Med." 57 FPDB16858 AP02388 RPDFCLEPPYTGPCKARMIRYFYNAKAGLCQPFVYGGCRAKRNNFKSSEDCMRTCGGA Antifungal||candidacidal||Enzyme inhibitor Bos taurus Combine Helix and Beta structure N/A "Mol Microbiol . 2014 Jun;92(6):1188-97. doi: 10.1111/mmi.12621. Epub 2014 May 8.|||Mol Microbiol. 2014 Jun;92(6):1188-97. PubMed" 58 FPDB16862 AP02523 KACPRNCDTDIAYMVCPSSGERIIRKVCTNCCAAQKGCKLFRSNGSIKCTGT Active again yeasts S. cerevisiae||C. albicans||C. tropicalis and K. marxianus. It also inhibited the alpha-amylase activities from C. maculatus and human saliva in vitro. This peptide S3 has an identical sequence to PSI-1.2 initially identified as serine proteinase inhibitor that inhibits both trypsin and chymotrypsin . Also refer to UniProKB: P83241.||Antifungal||candidacidal||Enzyme inhibitor seeds, Bell pepper, Capsicum annuum|||seeds, Bell pepper, Capsicum annuum Bridge N/A "Protein J . 2015 Apr;34(2):122-9. doi: 10.1007/s10930-015-9604-3.||Antcheva N et al., 2001|||Protein J. 2015 Apr;34(2):122-9. PubMed" 52 FPDB16865 AP03003 IATSPYYACNCPNNCKHKKGSGCKYHSGPSDKSKVISGKCEWQGGQLNCIAT Anti-C. albicans ATCC 10231, activity value is MIC = 6.25 ug/ml||Anti-C. glabrata CBS 138, activity value is MIC = 1.56 ug/ml||Anti-C. guilliermondii CBS 566, activity value is MIC = 1.56 ug/ml||Anti-C. krusei CBS 573, activity value is MIC = 12.5 ug/ml||Anti-C. lusitaniae CBS 6936, activity value is MIC = 3.1 ug/ml||Anti-C. parapsilosis CBS 604, activity value is MIC = 1.56 ug/ml||Anti-C. tropicalis CBS 94, activity value is MIC = 1.56 ug/ml||Anti-S. cerevisiae SZMC 0644, activity value is MIC = 3.1 ug/ml||Anti-and S. pombe SZMC 0142, activity value is MIC = 1.56 ug/ml||Antifungal||candidacidal Neosartorya fischeri Bridge N/A "Front Microbiol . 2018 Mar 7:9:393. doi: 10.3389/fmicb.2018.00393. eCollection 2018.|||Front Microbiol. 2018 Mar 7;9:393. doi: 10.3389/fmicb.2018.00393. PubMed" 52 FPDB16876 AP03607 SYYSTLQCRNNHGHCRRLCFHGEQWIGNCNGRHQHCCK Anti-C. albicans, activity value is MIC = 5 uM||activity value is IC50 = 4.1 uM saltwater crocodile, Crocodylus porosus|||saltwater crocodile, Crocodylus porosus Combine Helix and Beta structure N/A Nat Commun. 2023 Mar 1;14(1):1170. doi: 10.1038/s41467-023-36280-y. PubMed|||Nat Commun. 2023 Mar 1;14(1):1170. doi: 10.1038/s41467-023-36280-y. PubMed 38 FPDB16877 AP03722 GWLIRGAIHAGKAIHGLI Anti-C. albicans, activity value is MIC = 80 ug/ml||Anti-C. glabrata, activity value is MIC = 55 ug/ml||Anti-and C.auris, activity value is MIC = 160 ug/ml Sequence truncation N/A murine RBC, HC50 > 100 ug/ml, ~10% hemo.lytic at 100 ug/ml. Int J Mol Sci. 2023 Sep 13;24(18):14053. doi: 10.3390/ijms241814053. Pub-Med.|||Int J Mol Sci. 2023 Sep 13;24(18):14053. doi: 10.3390/ijms241814053. Pub-Med. 18 FPDB16879 AP03927 RLCTNCCAGRKGCNYYSADGTFICEGESDPNNPKA 39% growth inhibition of C. albicans was not peptide-dose dependent from 25 to 200 ug/ml. C. buinensis inhibition 37% at 100 ug/ml and 70% at 200 ug/ml. no effect on C.tropicalis or C.parapsilosis at 200 ug/ml. cell viability loss when treated at 200 ug/ml (53 uM) for 24 h: C. albicans and C. buinensis. CaCPin-II inhibited alpha-amylase activity. leaves, Capsicum annuum L. var. annuum|||leaves, Capsicum annuum L. var. annuum N/A 28% hemolysis at 200 ug/ml (53 uM).|||28% hemolysis at 200 ug/ml (53 uM). toxic to mammalian cells. Probiotics Antimicrob Proteins. 2023 Jun 26. doi: 10.1007/s12602-023-10112-3. PubMed|||Probiotics Antimicrob Proteins. 2023 Jun 26. doi: 10.1007/s12602-023-10112-3. PubMed 35 FPDB16880 AP03959 KRFRIRWAWRRA Anti-P. aeruginosa PAO1, activity value is MIC = 25 ug/ml||Anti-E. coli, activity value is MIC = 6 ug/ml||Anti-S-typhimurium, activity value is MIC > 25 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-S. epidermidis, activity value is MIC = 3.1 ug/ml||Anti-E-faecalis ATCC29212, activity value is MIC > 50 ug/ml||Anti-and C. albicans, activity value is MIC = 12 ug/ml Sequence variant of Bac3A, animal-derived, natural derivative|||Sequence variant of Bac2A, animal-derived, natural derivative Rich N/A Patent US9017657|||Patent US9017656 12 FPDB16881 AP04039 VPTTPFLCTNDPQCKVNYEDGHCFDILSK treated at 200 ug/ml (60.8 uM)||changed viability C. albicans||C. buinensi||and C. parapsilosis by ~37%. leaves, Capsicum annuum L. var. annuum|||leaves, Capsicum annuum L. var. annuum N/A not hemo.lytic at 400 ug/ml (121.6 uM). Probiotics Antimicrob Proteins. 2023 Jun 26. doi: 10.1007/s12602-023-10112-3. PubMed|||Probiotics Antimicrob Proteins. 2023 Jun 26. doi: 10.1007/s12602-023-10112-3. PubMed 29 FPDB16882 AP04040 GQQSCLCGYMKQYVNSPNARKVVGQCGVSVPNC treated at 200 ug/ml (56.8 uM)||changed viability of C. albicans and C. buinensis. leaves, Capsicum annuum L. var. annuum|||leaves, Capsicum annuum L. var. annuum N/A weak hemolysis at 200 ug/ml. Probiotics Antimicrob Proteins. 2023 Jun 26. doi: 10.1007/s12602-023-10112-3. PubMed|||Probiotics Antimicrob Proteins. 2023 Jun 26. doi: 10.1007/s12602-023-10112-3. PubMed 33 FPDB17434 DRAMP32318|||AP05520 RRIPFWPIPLRWQWPPPWFPPSFPIPRISRKR Antimicrobial||Anticancer||Anti-E. coli ATCC 25922, activity value is MIC = 6 uM||Anti-E. faecium ATCC 19434, activity value is MIC = 4 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 8 uM||Anti-K-pneumoniae ATCC 700603, activity value is MIC > 64 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 4 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 16 uM||Anti-E. agglomerans clinical isolate, activity value is MIC = 8 uM||Anti-S. maltophilia ATCC 13637, activity value is MIC = 4 uM||Anti-C. albicans ATCC 90029, activity value is MIC = 8 uM Synthetic|||Beluga whale, Delphinapterus leucas Rich N/A Int J Mol Sci. 2020 Oct 6;21(19):7367.|||Int J Mol Sci. 2020 Oct 6;21(19):7367. doi: 10.3390/ijms21197367. PubMed 32 FPDB17435 DRAMP32319|||AP05519 RRIPFWPPNLPGPRRPPWFLPDFRIPRIPRKR Antimicrobial||Anticancer||Anti-E. coli ATCC 25922, activity value is MIC = 6 uM||Anti-E. faecium ATCC 19434, activity value is MIC = 16 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 32 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 32 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 32 uM||Anti-E. agglomerans clinical isolate, activity value is MIC = 8 uM||Anti-S. maltophilia ATCC 13637, activity value is MIC = 2 uM||Anti-C. albicans ATCC 90029, activity value is MIC = 4 uM Synthetic|||killer whale, Orcinus orca Rich N/A Int J Mol Sci. 2020 Oct 6;21(19):7367.|||Int J Mol Sci. 2020 Oct 6;21(19):7367. doi: 10.3390/ijms21197367. PubMed 32 FPDB17437 DRAMP32321|||AP05522 RRIRFRPPRLPRPRPRPWIPPRFPFPRIPGKR Antimicrobial||Anticancer||Anti-E. coli ATCC 25922, activity value is MIC = 1 uM||Anti-E. faecium ATCC 19434, activity value is MIC = 4 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 16 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 1 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 1 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 2 uM||Anti-E. agglomerans clinical isolate, activity value is MIC = 0.5 uM||Anti-S. maltophilia ATCC 13637, activity value is MIC = 1 uM||Anti-C. albicans ATCC 90029, activity value is MIC = 0.5 uM Synthetic|||common minke whale, Balaenoptera acutorostrata Rich N/A Int J Mol Sci. 2020 Oct 6;21(19):7367.|||Int J Mol Sci. 2020 Oct 6;21(19):7367. doi: 10.3390/ijms21197367. PubMed 32 FPDB17438 DRAMP32322|||AP05523 RRIRIRPPRLPRPRPRPWFPPRFPIPRIPGKR Antimicrobial||Anticancer||Anti-E. coli ATCC 25922, activity value is MIC = 1 uM||Anti-E. faecium ATCC 19434, activity value is MIC = 4 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 16 uM||Anti-K. pneumoniae ATCC 700603, activity value is MIC = 1 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 1 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 2 uM||Anti-E. agglomerans clinical isolate, activity value is MIC = 0.5 uM||Anti-S. maltophilia ATCC 13637, activity value is MIC = 0.5 uM||Anti-C. albicans ATCC 90029, activity value is MIC = 2 uM Synthetic|||Baiji, Lipotes vexillifer, China, Asia Rich N/A Int J Mol Sci. 2020 Oct 6;21(19):7367.|||Int J Mol Sci. 2020 Oct 6;21(19):7367. doi: 10.3390/ijms21197367. PubMed 32 FPDB21201 AP02018 HTPTPTPICKSRSHEYKGRCIQDMDCNAACVKESESYTGGFCNGRPPFKQCFCTKPCKRERAAATLRWP Antifungal Sugarcane, Saccharum officinarum Combine Helix and Beta structure N/A Plant Mol Biol. 2008 Nov;68(4-5):321-35.PubMed 69 FPDB21202 AP02067 QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGPTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGF Anti-Gram+||Antifungal||candidacidal||anti-TB liver, intestine, skin, Homo sapiens Combine Helix and Beta structure N/A Nat Immunol. 2003 Mar;4(3):269-73.Pub-Med. GenBank: AAH62698.1. 100 FPDB21203 AP02073 KPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKYPNCRYKEKRQ Anti-Gram+ & Gram-||Antiviral||Antifungal||anti-TB keratinocytes, Skin (e.g. hair follicle), urinary tract, Homo sapiens, including pre-term and term infants Combine Helix and Beta structure N/A J Biol Chem. 2002 Nov 29;277(48):46779-84. Pub-Med. GenBank:NP_115961.2. 98 FPDB21204 AP02095 SGKSFKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMC Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-inflammatory||Enzyme inhibitor tears, saliva, airway, gastrointestines, genital tracts, Homo sapiens Beta N/A J Bacteriol. 1989 Apr;171(4):2166-72. Pub-Med. GenBank:CAA28187.1 97 FPDB21205 AP02097 KPKDMTSSQWFKTQHVQPSPQACNSAMSIINKYTERCKDLNTFLHEPFSSVAITCQTPNIACKNSCKNCHQSHGPMSLTMGELTSGKYPNCRYKEKHLN Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA Homo sapiens N/A little hemolysis till 28 uM. Antimicrob Agents Chemother. 2006 Sep;50(9):3194-6. Pub-Med. GenBank:AEX57301.1 99 FPDB21206 AP02120 YVPKIPKPQPNKPNFPSFPGHGPFNPHASRFPRSPKDNGKIVFDAKKEGGKTQWNVETQQKVWGNKHGSIHVSAGAGKQPGGKPQGQVGIGGSFSWG Anti-Gram+ & Gram-||Antifungal parasitic wasp Nasonia vitripennis N/A N/A Biochem Biophys Res Commun. 2012 Nov 23;428(3):360-4. Pub-Med. 97 FPDB21207 AP02168 TDHQMAQSACIGVSQDNAYASAIPRDCHGGKTCEGICADATATMDRYSDTGGPLSIARCVNAFHFYKRRGEENVSYKPFVVSWKYGVAGCFYTHCGPNF Anti-Gram+ & Gram-||Antifungal||candidacidal circulating hemocyte, sea mussel, Mytilus coruscus Bridge N/A Fish Shellfish Immunol. 2013 Feb;34(2):610-616. Pub-Med. 99 FPDB21208 AP02186 MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCH Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Chemotactic saliva, milk, epithelial cells/mucosal tissues, Homo sapiens Combine Helix and Beta structure N/A J Immunol. 2003 Feb 1;170(3):1452-61.Pub-Med. 100 FPDB21209 AP02188 FQTSEAILPMASSCCTEVSHHVSGRLLERVSSCSIQRADGDCDLAAVILHVKRRRICISPHNRTLKQWMRASEVKKNGRENVCSGKKQPSRKDRKGHTTR Anti-Gram+ & Gram-||Antifungal||candidacidal||Chemotactic Mus musculus N/A N/A J Immunol. 2003 Feb 1;170(3):1452-61.Pub-Med. 100 FPDB21210 AP02195 ELTEAQRRGLQVALEEFHKHPPVQWAFQETSVESAVDTPFPAGIFVRLEFKLQQTSCRKRDWKKPECKVRPNGRKRKCLACIKLGSEDKVLGRLVHCPIETQ Anti-Gram+ & Gram-||Antifungal||candidacidal||Chemotactic epidermis, skin, Homo sapiens N/A N/A J Immunol. 2011 Aug 1;187(3):1403-10. Pub-Med. 102 FPDB21211 AP02206|||AP02207 DVYKGGGGGRYGGGRYGGGGGYGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGGLGGGGLGGGKGLGG Anti-Gram-||Antifungal||candidacidal Acanthoscurria gomesiana Rich N/A Dev Comp Immunol. 2003 Oct;27(9):781-91.Pub-Med. 96 FPDB21212 AP02257 KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRV Anti-Gram+ & Gram-||Antifungal||Synergistic AMPs plasma serum, Secretions and Tissues, tears, saliva, sweat, human milk, colonic mucosa, and mucus; Homo sapiens Combine Helix and Beta structure N/A Br J Exp Pathol. 1922 October; 3(5): 252–260. Pub-Med Central. 99 FPDB21213 AP02339 KTFTRCELVQALRRQGFDEAKLRDWVCLVENESRGRTDIVGKPNKNGSRDYGLFQINDKYWCSNTSKAGKDCNITCSQLLTDDITVASKCAK Antifungal||candidacidal greater wax moth, Galleria mellonella N/A N/A Peptides. 2014 Jan 25. pii: S0196-9781(14)00015-1. doi: 10.1016/j.peptides.2014.01.012.PubMed; 92 FPDB21214 AP02442 QVLEGLAAAVTGKLAGLWRNGEVELLGHYCSYSVTPTIRRWQLYFRGRMWCPGWTSIRGEAMTRSNSGVQGDTTRDFVTKALNAGLISQQ Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis red swamp crayfish, Procambarus clarkii N/A N/A Fish Shellfish Immunol. 2011 Jan;30(1):295-303. PubMed 90 FPDB21215 AP02620 ESFLKSKTGYQGVQTLPGFIGGSQPHLGGGIGGGRPFISQPNLGGGIGGGIGGGKPFIPQPNLGGGIGSTRPFPRPQYGDYGSRNSCNRQC Anti-Gram+ & Gram-||Antifungal||candidacidal hemocytes; spider crab; Hyas araneus Rich N/A Mol Immunol. 2009 Aug;46(13):2604-12. PubMed 91 FPDB21216 AP02628 MGPVNEANCKAAMEIVCRREFGHKEEEDASEGVTTGDPDCPFTKAIPREEYANKYGPTIGDKIRLGDTDLIAEIEKDFALYGDESVFGGGKV Antifungal||candidacidal||Insecticidal Canavalia ensiformis Helix N/A Peptides. 2007 Oct;28(10):2042-50. PubMed 92 FPDB21217 AP02694 WYVRKCANKLGTCRKTCRKGEYQTDPATGKCSIGKLCCILDLKLAGQCGGADGNQAAAGTQAAGGTRAAGGTQGTGGTGATGAAATTAA Anti-Gram-||Antifungal||candidacidal secreted fluid, epididymis; sperm tail; Rattus norvegicus Bridge N/A Asian J Androl. 2011 Mar;13(2):305-11.PubMed 89 FPDB21218 AP02851 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAA Anti-Gram+ & Gram-||Antifungal||candidacidal Brain, Homo sapiens Helix N/A Biochem Biophys Res Commun. 2016 Sep 16;478(2):924-8. doi: 10.1016/j.bbrc.2016.08.052. PubMed 90 FPDB21219 AP02894 GVVLNVNPGKSLEEPAVKHLKVSPVNANEVPVLKELKSVQKTKSGDTLYGFVCTVGQIKTDSLGCVGSDSVAWPSEQNVELTVSCDKSNV Antifungal||candidacidal||Antibiofilm housefly, Musca domestica N/A N/A Biochem Biophys Res Commun. 2017 Aug 26;490(3):746-752. doi: 10.1016/j.bbrc.2017.06.112. PubMed 90 FPDB21220 AP03002 NWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPADRRANYPVFCVQTKTTRISTVTATTATTTLMMTTASMSSMAPTPVSP Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory||anti-sepsis epididymis, Homo sapiens Bridge N/A Appl Microbiol Biotechnol. 2013 Apr;97(8):3395-408. doi: 10.1007/s00253-012-4588-9. PubMed 89 FPDB21221 AP03086 MLVNFILRCGLLLVTLSLAIAKHKQSSFTKSCYPRGTLSQAVDALYIKAAWLKATIPEDRIKNIRLLKKKTKKQFMKNCQFQEQLLSFFMEDV Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA Th17 cells, Homo sapiens N/A N/A J Immunol. 2019 Jun 24. pii: ji1900318. doi: 10.4049/jimmunol.1900318. PubMed 93 FPDB21222 AP03106 MSLLQRSMVLVAAVFCLSAIYVSAEAEVDANCLGCMCEAATRCNASTACHNSGGGYFCGPFHISWAYWADAGKPVLLHDDPNRLGAFED Anti-Gram+ & Gram-||Antifungal||candidacidal||bacteria-agglutinating AMPs the mud crab, Scylla paramamosain N/A N/A Dev Comp Immunol. 2017 Sep;74:154-166. doi: 10.1016/j.dci.2017.04.017. PubMed 89 FPDB21223 AP03107 DDTRGGFHGGGFGRPGRPGRPGSGILDTIVDGLTGSIHGGQGGIHGGIHGGGHGGHGGVVHGRQCGVNVPTHITTGCKLFTRNLYGQYVC Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis||bacteria-agglutinating AMPs the mud crab, Scylla paramamosain N/A N/A Dev Comp Immunol. 2018 Jul;84:1-13. doi: 10.1016/j.dci.2018.01.021. PubMed 90 FPDB21224 AP03110 QFGGSDCIHWCRTPENQVYCCKDTHDPIPASPVAVVNPGRCPPIRGQCPNVRVFRPPTTCSSDSDCSYNNKCCFDRCLEEHVCKPTTGGF Anti-Gram+ & Gram-||Antifungal||candidacidal||bacteria-agglutinating AMPs Gill, the mud crab, Scylla paramamosain N/A N/A Fish Shellfish Immunol. 2018 Apr;75:346-356. doi: 10.1016/j.fsi.2018.02.026. PubMed 90 FPDB21225 AP03193 GICRCVCRRGVCRCICLL Antifungal||candidacidal Papio anubis Bridge All peptides, with the exception of BTD-8, produced < 1.3% hemolysis in either medium. BTD-8 caused 2.8% hemolysis in the 2% erythrocyte suspension. Antimicrob Agents Chemother. 2018 May 25;62(6):e00111-18. doi: 10.1128/AAC.00111-18. PubMed 18 FPDB21226 AP03194 GVCRCVCRRGVCRCFCRR Antifungal||candidacidal Papio anubis Bridge All peptides, with the exception of BTD-8, produced < 1.3% hemolysis in either medium. BTD-8 caused 2.8% hemolysis in the 2% erythrocyte suspension. Antimicrob Agents Chemother. 2018 May 25;62(6):e00111-18. doi: 10.1128/AAC.00111-18. PubMed 18 FPDB21227 AP03195 GICRCFCRRGVCRCICLL Antifungal||candidacidal Papio anubis Bridge All peptides, with the exception of BTD-8, produced < 1.3% hemolysis in either medium. BTD-8 caused 2.8% hemolysis in the 2% erythrocyte suspension. Antimicrob Agents Chemother. 2018 May 25;62(6):e00111-18. doi: 10.1128/AAC.00111-18. PubMed 18 FPDB21228 AP03196 GVCRCFCRRGVCRCFCRR Antifungal||candidacidal Papio anubis Bridge All peptides, with the exception of BTD-8, produced < 1.3% hemolysis in either medium. BTD-8 caused 2.8% hemolysis in the 2% erythrocyte suspension. Antimicrob Agents Chemother. 2018 May 25;62(6):e00111-18. doi: 10.1128/AAC.00111-18. PubMed 18 FPDB21229 AP03199 KESRAKKFQRQHMDSDSSPSSSSTYCNQMMRRRNMTQGRCKPVNTFVHEPLVDVQNVCFQEKVTCKNGQGNCYKSNSSMHITDCRLTN Anti-Gram-||Antifungal||candidacidal pancreatic, Homo sapiens Combine Helix and Beta structure N/A Int J Biol Macromol. 2020; 160:1042-1049. doi:10.1016/j.ijbiomac.2020.06.001. PubMed 88 FPDB21230 AP03203 VNDCIRIHCKDDFDCIENRLQVGCRLQREKPRCVNLVCRCLRR Antifungal||candidacidal symbiont bacteria, legume Medicago truncatula N/A N/A Biomed Res Int. 2014;2014:320796. doi:10.1155/2014/320796. PubMed 43 FPDB21231 AP03204 MKNGCKHTGHCPRKMCGAKTTKCRNNKCQCVQL Antifungal||candidacidal symbiont bacteria, legume Medicago truncatula N/A N/A Biomed Res Int. 2014;2014:320796. doi:10.1155/2014/320796. PubMed 33 FPDB21232 AP03205 MTLRPCLTDKDCPRMPPHNIKCRKGHCVPIGKPFK Antifungal||candidacidal symbiont bacteria, legume Medicago truncatula N/A N/A Biomed Res Int. 2014;2014:320796. doi:10.1155/2014/320796. PubMed 35 FPDB21233 AP03206 IYFPVSRPCITDKDCPNMKHYKAKCRKGFCISSRVR Antifungal||candidacidal symbiont bacteria, legume Medicago truncatula N/A N/A Biomed Res Int. 2014;2014:320796. doi:10.1155/2014/320796. PubMed 36 FPDB21234 AP03207 MRVLCGRDGRCPKFMCRTFL Antifungal||candidacidal symbiont bacteria, legume Medicago truncatula N/A N/A Biomed Res Int. 2014;2014:320796. doi:10.1155/2014/320796. PubMed 20 FPDB21235 AP03208 ITISNSSFGRIVYWNCKTDKDCKQHRGFNFRCRSGNCIPIRR Antifungal||candidacidal symbiont bacteria, legume Medicago truncatula N/A N/A Biomed Res Int. 2014;2014:320796. doi:10.1155/2014/320796. PubMed 42 FPDB21236 AP03210 AFLPTSRNCITNKDCRQVRNYIARCRKGQCLQSPVR Antifungal||candidacidal symbiont bacteria, legume Medicago truncatula N/A N/A Biomed Res Int. 2014;2014:320796. doi:10.1155/2014/320796. PubMed 36 FPDB21237 AP03336 PAGPFRIPKCRKEFQQAQHLRACQQWLHKQAMQSGSGPSWTLDDEFDFEDDMENPQGPQQRPPLLQQCCNELHQEEPLCVCPTLKGASK Antifungal||candidacidal Seeds, white mustard, Brassica hirta N/A N/A Biochem Biophys Rep. 2022 Jan 15;29:101208. doi: 10.1016/j.bbrep.2022.101208. PubMed 89 FPDB21238 AP03446 LLGDFFRKSKEKIGKEFKRIVQRIK LL-25 is even more active against C. albicans than its parent peptide LL-37 (activity data not reported). However||LL-25 lost imumune regulatory activity. protease truncation, host-pathogen war, human cathelicidin analog, animal-derived, natural derivative N/A N/A Infect Immun. 2015 Jun;83(6):2518-30. doi: 10.1128/IAI.00023-15. PubMed 25 FPDB21239 AP03447 SKEKIGKEFKRIVQRIKDFLRNLVPRTES SK-29 is active against C. albicans (MIC data not reported). Like LL-37||it also retains ROS stimulation activity from neutrophils. It demonstrated weaker apoptosis inhibitory activity as well as IL-8 release from neutrophils. host-pathogen war, human cathelicidin analog, animal-derived, natural derivative N/A N/A Infect Immun. 2015 Jun;83(6):2518-30. doi: 10.1128/IAI.00023-15. PubMed 29 FPDB21240 AP03456 MRSLLILVLCFLPLAALGKVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDG Anti-M. luteus A270, activity value is MIC = 0.01 Chicken, Gallus gallus N/A N/A Front Immunol. 2017 Jan 9;7:664. doi: 10.3389/fimmu.2016.00664. PubMed 67 FPDB21241 AP03767 CGVNVPTHITTGCKLFTRNLYGQYVCDRNQKPAFRCPPLRAECPLATRFGPPIQCTLDTDCPGISD Anti-Gram+ S. aureus, activity value is MIC = 2.8||Anti-B. subtilis, activity value is MIC = 2.8||Anti-and B. megaterium, activity value is MIC = 2.8 Sequence truncation, Crustaceans, animal-derived, natural derivative N/A N/A Dev Comp Immunol. 2018 Jul;84:1-13. doi: 10.1016/j.dci.2018.01.021. PubMed 66 FPDB21242 AP04501 TNAIIVAGQLALWAVQCGLS active against C. albicans based on the survival of the infected animal model:Caenorhabditis elegans. sequence truncation, bacteria-derived, natural derivative N/A N/A Nat Commun. 2022 Oct 13;13(1):6047. doi: 10.1038/s41467-022-33613-1. PubMed 20 FPDB21243 AP04502 AIIVAGQLALWAVQCG active against C. albicans based on the survival of the infected animal model:Caenorhabditis elegans. Also effective against C. auris and C. neoformans. sequence truncation, bacteria-derived, natural derivative N/A N/A Nat Commun. 2022 Oct 13;13(1):6047. doi: 10.1038/s41467-022-33613-1. PubMed 16 FPDB21244 AP04503 IIVAGQLALWAVQC active against C. albicans based on the survival of the infected animal model:Caenorhabditis elegans. sequence truncation, bacteria-derived, natural derivative N/A N/A Nat Commun. 2022 Oct 13;13(1):6047. doi: 10.1038/s41467-022-33613-1. PubMed 14 FPDB21245 AP04504 AIIVAGQLALWAVQ active against C. albicans based on the survival of the infected animal model:Caenorhabditis elegans. sequence truncation, bacteria-derived, natural derivative N/A N/A Nat Commun. 2022 Oct 13;13(1):6047. doi: 10.1038/s41467-022-33613-1. PubMed 14 FPDB21246 AP04506 AGQLALWAVQC active against C. albicans based on the survival of the infected animal model:Caenorhabditis elegans||although reduced compared to the parent peptide. sequence truncation, bacteria-derived, natural derivative N/A N/A Nat Commun. 2022 Oct 13;13(1):6047. doi: 10.1038/s41467-022-33613-1. PubMed 11 FPDB21247 AP04507 GQLALWAVQC active against C. albicans based on the survival of the infected animal model:Caenorhabditis elegans||although reduced compared to the parent peptide. sequence truncation, bacteria-derived, natural derivative N/A N/A Nat Commun. 2022 Oct 13;13(1):6047. doi: 10.1038/s41467-022-33613-1. PubMed 10 FPDB21248 AP04627 RERDHELRHRRHHHQ Anti-C. albicans, activity value is ED50 = 39.95 uM Sequence alignment Rich N/A Biochim Biophys Acta. 1999 Apr 12;1431(1):107-19. doi: 10.1016/s0167-4838(99)00034-5. PubMed 15 FPDB21249 AP04810 ICEALSGNFKGLCLSSRREGFTDGSCIGFRLQCFCTKPCA active against fungi C. buinensis||C. tropicalis||C. albicans||and C parapsilosis at 100 ug/ml. fruits, Capsicum annuum Bridge N/A Probiotics Antimicrob Proteins. 2020 Sep;12(3):1253-1265. doi: 10.1007/s12602-020-09647-6. PubMed 40 FPDB21250 AP04811 SKYFTGLCWTDSSCRKVCIEKDFQDGHCSKIQR active against fungi C. buinensis||C. tropicalis||C. albicans||and C parapsilosis at 100 ug/ml. fruits, Capsicum annuum Bridge N/A Probiotics Antimicrob Proteins. 2020 Sep;12(3):1253-1265. doi: 10.1007/s12602-020-09647-6. PubMed 33 FPDB21251 AP04812 MMMMRMQQEEMQPR active against fungi C. albicans and C. tropicalis (50-200 ug/ml). It also inhibited trypsin enzyme activity. Capsicum annuum N/A N/A Pept Sci. 2024;116:e24338. 14 FPDB21252 AP05015 MRIHYLLFAVLFLFLMPVPGEGGIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGKCCRTR active against bacteria E. coli NTHI 86-028NP||S. pneumoniae type 14||and M. catarrhalis 1857||and the fungus C. albicans. All essentially killed at 20 ug/ml. Non-standard assay: killing effect: incubated 1 h followed by plating to detect survival bacteria. Airway, Chinchilla lanigera Bridge N/A J Biol Chem. 2004 May 7;279(19):20250-6. doi: 10.1074/jbc.M400499200. PubMed 65 FPDB21253 AP05037 GGHGGHGGHGGHGGHGGHGHGGGGHG Anti-C. albicans MDM8, activity value is MIC = 25 uM||Anti-C.albicans ATCC 90028, activity value is MIC > 100 uM||Anti-C. albicans HU 168, activity value is MIC = 100 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 6.25 uM||Anti-C.krusei ATCC 6258, activity value is MIC > 100 uM||Anti-C. tropicalis Squibb 1600, activity value is MIC = 3.13 uM||Anti-and S. cerevisiae ATCC 2601, activity value is MIC = 25 uM sequence truncation, plant-derived, natural derivatives Rich N/A Amino Acids. 2014 Nov;46(11):2573-86. doi: 10.1007/s00726-014-1811-2. PubMed 26 FPDB21254 AP05038 GYGGHGGHGGHGGHGGHGGH Anti-C. albicans MDM8, activity value is MIC = 50 uM||Anti-C.albicans ATCC 90028, activity value is MIC > 100 uM||Anti-C.albicans HU 168, activity value is MIC > 100 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 12.5 uM||Anti-C.krusei ATCC 6258, activity value is MIC > 100 uM||Anti-C. tropicalis Squibb 1600, activity value is MIC = 3.13 uM||Anti-and S. cerevisiae ATCC 2601, activity value is MIC = 50 uM sequence truncation, plant-derived, natural derivatives Rich N/A Amino Acids. 2014 Nov;46(11):2573-86. doi: 10.1007/s00726-014-1811-2. PubMed 20 FPDB21255 AP05039 GGHGGHGGHGGHGGHGGH Anti-C. albicans MDM8, activity value is MIC = 100 uM||Anti-C.albicans ATCC 90028, activity value is MIC > 100 uM||Anti-C.albicans HU 168, activity value is MIC > 100 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 12.5 uM||Anti-C.krusei ATCC 6258, activity value is MIC > 100 uM||Anti-C. tropicalis Squibb 1600, activity value is MIC = 6.25 uM||Anti-and S. cerevisiae ATCC 2601, activity value is MIC = 50 uM sequence truncation, plant-derived, natural derivatives Rich N/A Amino Acids. 2014 Nov;46(11):2573-86. doi: 10.1007/s00726-014-1811-2. PubMed 18 FPDB21256 AP05042 GGHGGHGGHGGHGGHGHGGGGHG Anti-C. albicans MDM8, activity value is MIC = 12.5 uM||Anti-C.albicans ATCC 90028, activity value is MIC > 100 uM||Anti-C. albicans HU 168, activity value is MIC = 50 uM||Anti-C. parapsilosis ATCC 22019, activity value is MIC = 6.25 uM||Anti-C. krusei ATCC 6258, activity value is MIC = 100 uM||Anti-C. tropicalis Squibb 1600, activity value is MIC = 1.56 uM||Anti-and S. cerevisiae ATCC 2601, activity value is MIC = 12.5 uM sequence truncation, plant-derived, natural derivatives Rich N/A Amino Acids. 2014 Nov;46(11):2573-86. doi: 10.1007/s00726-014-1811-2. PubMed 23 FPDB21257 AP05146 WNLLRQAQEKFGKDKSPK Active against C. albicans by membrane permeation. sequence extension, animal-derived, natural derivative N/A N/A Biochimie. 2009 Jan;91(1):141-54. doi: 10.1016/j.biochi.2008.04.013. PubMed 18 FPDB21258 AP05147 DAIWNLLRQAQEKFGKDKSPK Active against C. albicans by membrane permeation. sequence extension, animal-derived, natural derivative N/A N/A Biochimie. 2009 Jan;91(1):141-54. doi: 10.1016/j.biochi.2008.04.013. PubMed 21 FPDB21259 AP05148 DAIWNLLRQAQEKFGKNKSPK Active against C. albicans by membrane permeation. amino acid SUBSTITUTION, sequence extension, animal-derived, natural derivative N/A N/A Biochimie. 2009 Jan;91(1):141-54. doi: 10.1016/j.biochi.2008.04.013. PubMed 21 FPDB21260 AP05274 RTCEHLADTYRGPCFTNASCDDHCKNKAHLISGTCHNFQCFCTQNC active against S. aureus||E. coli and C. albicans. "seeds, Medicago sativa ""Sazova"" cultivar" Bridge N/A Biochem Biophys Res Commun. 2025 Apr 9;757:151617. doi: 10.1016/j.bbrc.2025.151617. PubMed 46 FPDB21261 AP05418 HKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (1.4 mm)||E. coli ATCC 25922 (2.2 mm)||S. aureus ATCC 29213 (0.8 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 17 FPDB21262 AP05419 HKHGHGHGKHKNKGKKNL diffusion assay at 100 uM: active against C. albicans ATCC 90028 (3.2 mm)||E. coli ATCC 25922 (2.7 mm)||S. aureus ATCC 29213 (3.9 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 18 FPDB21263 AP05420 HKHGHGHGKHKNKGKKNLL diffusion assay at 100 uM: active against C. albicans ATCC 90028 (3.3 mm)||E. coli ATCC 25922 (3.8 mm)||S. aureus ATCC 29213 (3.8 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 19 FPDB21264 AP05421 HKHGHGHGKHKNKGKKNLLL diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.7 mm)||E. coli ATCC 25922 (4.9 mm)||S. aureus ATCC 29213 (5.7 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21265 AP05422 HKHGHGHGKHKNKGKKNWWW diffusion assay at 100 uM: active against C. albicans ATCC 90028 (8.8 mm)||E. coli ATCC 25922 (9.2 mm)||S. aureus ATCC 29213 (6.9 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21266 AP05423 HKHGHGHGKHKNKGKKNFFF diffusion assay at 100 uM: active against C. albicans ATCC 90028 (8.8 mm)||E. coli ATCC 25922 (9.2 mm)||S. aureus ATCC 29213 (6.9 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21267 AP05424 GKHKNKGKKNGKHNGWK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (3.8 mm)||E. coli ATCC 25922 (5.9 mm)||S. aureus ATCC 29213 (3.2 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 17 FPDB21268 AP05425 GKHKNKGKKNGKHNGWKL diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.4 mm)||E. coli ATCC 25922 (6.1 mm)||S. aureus ATCC 29213 (4.4 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 18 FPDB21269 AP05426 GKHKNKGKKNGKHNGWKLL diffusion assay at 100 uM: active against C. albicans ATCC 90028 (5.5 mm)||E. coli ATCC 25922 (10.2 mm)||S. aureus ATCC 29213 (4.3 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 19 FPDB21270 AP05427 GKHKNKGKKNGKHNGWKLLL diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.1 mm)||E. coli ATCC 25922 (9.6 mm)||S. aureus ATCC 29213 (4.9 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21271 AP05429 GKHKNKGKKNGKHNGWKFFF diffusion assay at 100 uM: active against C. albicans ATCC 90028 (8.0 mm)||E. coli ATCC 25922 (8.5 mm)||S. aureus ATCC 29213 (7.2 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21272 AP05430 LHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (0.9 mm)||E. coli ATCC 25922 (2.3 mm)||S. aureus ATCC 29213 (2.0 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 18 FPDB21273 AP05431 LLHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (1.9 mm)||E. coli ATCC 25922 (2.8 mm)||S. aureus ATCC 29213 (2.9 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 19 FPDB21274 AP05432 LLLHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.5 mm)||E. coli ATCC 25922 (5.9 mm)||S. aureus ATCC 29213 (3.6 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21275 AP05433 AAAHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (1.5 mm)||E. coli ATCC 25922 (2.2 mm)||S. aureus ATCC 29213 (2.1 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21276 AP05434 IIIHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.5 mm)||E. coli ATCC 25922 (4.4 mm)||S. aureus ATCC 29213 (4.1 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21277 AP05435 VVVHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.7 mm)||E. coli ATCC 25922 (3.7 mm)||S. aureus ATCC 29213 (4.1 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21278 AP05436 PPPHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.6 mm)||E. coli ATCC 25922 (2.2 mm)||S.aureus ATCC 29213 (0 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21279 AP05437 YYYHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (5.8 mm)||E. coli ATCC 25922 (7.1 mm)||S.aureus ATCC 29213 (4.5 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21280 AP05438 FFFHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.5 mm)||E. coli ATCC 25922 (8.9 mm)||S. aureus ATCC 29213 (4.1 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21281 AP05439 WWWHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (7.0 mm)||E. coli ATCC 25922 (9.0 mm)||S. aureus ATCC 29213 (4.7 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21282 AP05440 FFHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (3.7 mm)||E. coli ATCC 25922 (2.3 mm)||S. aureus ATCC 29213 (3.3 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 19 FPDB21283 AP05441 WWHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (5.1 mm)||E. coli ATCC 25922 (3.5 mm)||S. aureus ATCC 29213 (3.6 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 19 FPDB21284 AP05442 FHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (6.1 mm)||E. coli ATCC 25922 (7.9 mm)||S. aureus ATCC 29213 (4.4 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 18 FPDB21285 AP05443 WHKHGHGHGKHKNKGKKN diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.0 mm)||E. coli ATCC 25922 (4.3 mm)||S. aureus ATCC 29213 (4.1 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 18 FPDB21286 AP05444 LLLNKKGKNKHKGHGHGHKH diffusion assay at 100 uM: active against C. albicans ATCC 90028 (5.9 mm)||E. coli ATCC 25922 (4.9 mm)||S. aureus ATCC 29213 (4.0 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21287 AP05445 WWWWHKHGHGHGKHKNKGKK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (5.8 mm)||E. coli ATCC 25922 (8.3 mm)||S. aureus ATCC 29213 (5.1 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21288 AP05446 FFFFHKHGHGHGKHKNKGKK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (7.7 mm)||E. coli ATCC 25922 (8.1 mm)||S. aureus ATCC 29213 (3.9 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21289 AP05447 LLLLHKHGHGHGKHKNKGKK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (8.2 mm)||E. coli ATCC 25922 (8.1 mm)||S. aureus ATCC 29213 (3.9 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21290 AP05448 IIIIHKHGHGHGKHKNKGKK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.8 mm)||E. coli ATCC 25922 (5.9 mm)||S. aureus ATCC 29213 (3.4 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21291 AP05449 LGKHKNKGKKNGKHNGWK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (3.5 mm)||E. coli ATCC 25922 (4.0 mm)||S. aureus ATCC 29213 (2.6 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 18 FPDB21292 AP05450 LLGKHKNKGKKNGKHNGWK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.2 mm)||E. coli ATCC 25922 (7.5 mm)||S. aureus ATCC 29213 (3.4 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 19 FPDB21293 AP05451 LLLGKHKNKGKKNGKHNGWK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (5.2 mm)||E. coli ATCC 25922 (7.2 mm)||S. aureus ATCC 29213 (3.7 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21294 AP05452 AAAGKHKNKGKKNGKHNGWK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (3.4 mm)||E. coli ATCC 25922 (5.4 mm)||S. aureus ATCC 29213 (2.8 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21295 AP05453 IIIGKHKNKGKKNGKHNGWK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (4.8 mm)||E. coli ATCC 25922 (6.6 mm)||S. aureus ATCC 29213 (3.3 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21296 AP05454 FFFGKHKNKGKKNGKHNGWK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (5.9 mm)||E. coli ATCC 25922 (7.5 mm)||S. aureus ATCC 29213 (3.9 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21297 AP05455 WWWGKHKNKGKKNGKHNGWK diffusion assay at 100 uM: active against C. albicans ATCC 90028 (7.1 mm)||E. coli ATCC 25922 (9.8 mm)||S. aureus ATCC 29213 (4.1 mm). Designed, Peptide conjugates Rich N/A J Biol Chem. 2009 Jun 26;284(26):17584-94. doi: 10.1074/jbc.M109.011650. PubMed 20 FPDB21298 AP05521 RRIRFPFPPFPWQWPPAGF Anti-E. coli ATCC 25922, activity value is MIC = 16 uM||Anti-E-faecium ATCC 19434, activity value is MIC > 64 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 16 uM||Anti-K-pneumoniae ATCC 700603, activity value is MIC > 64 uM||Anti-A. baumannii ATCC 19606, activity value is MIC = 16 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 64 uM||Anti-E. agglomerans clinical isolate, activity value is MIC = 64 uM||Anti-S. maltophilia ATCC 13637, activity value is MIC = 24 uM||Anti-C. albicans ATCC 90029, activity value is MIC = 32 uM Yangtze finless porpoise, Neophocaena asiaeorientalis , China, Asia Rich N/A Int J Mol Sci. 2020 Oct 6;21(19):7367. doi: 10.3390/ijms21197367. PubMed 19