Unique_ID	Origin_ID	Sequence	Activity	Source	Structure	Hemolysis	Reference	Length	Stereo
FPDB00036	AP00310|||AP00310|||LL-37|||LL-37|||AP00310	LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||Chemotactic||Anti-MRSA||Enzyme inhibitor||anti-TB||anti-sepsis||Synergistic AMPs||Hemolytic||Antibiofilm||Wound healing||Anticancer||Anti-L. monocytogenes EGD, activity value is MIC = 1.5 ug/ml||Antibacterial||Anti-S. aureusNCTC 6571, activity value is MIC = 19.3||Anti-E. coli ATCC 25922, activity value is MIC = 9.8||Anti-27367675: E.coli K88, activity value is MIC = 61||Anti-E.coli CVCC245, activity value is MIC = 61||Anti-S.aureus CVCC 26003, activity value is MIC = 36||Anti-S.aureus ATCC 25923, activity value is MIC = 58||Anti-Listeria monocytogene CVCC 1599, activity value is MIC = 13||Anti-Micrococcus luteus CVCC 28001, activity value is MIC = 90||Anti-A. baumannii ATCC 19606, activity value is MIC = 4 ug/ml||Anti-29022391 : S. mutans, activity value is MIC = 250 ug/ml||Anti-A. israelii, activity value is MIC = 7.81 ug/ml||Anti-E. faecalis, activity value is MIC = 2000 ug/ml||Anti-31417238: Streptococcus agalactiae NEM 316, activity value is MIC = 90||Anti-C-terminal:COOH): A. baumannii 6043, activity value is MIC = 14.2 uM||Anti-P. aeruginosa ATCC 19660, activity value is MIC = 28.5 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 28.5 uM||Anti-28649410: P. aeruginosa ATCC 9027, activity value is EC50 = 0.525 uM||Anti-P. aeruginosa PAO1 (pTDKGFP, activity value is EC50 = 0.599 uM||Anti-F. novicida U112, activity value is EC50 = 0.0534 uM||Anti-B. thailandensis E264, activity value is EC50 = 1.88 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 0.552 uM||Anti-31016971: Staphylococcus aureus SA113 WT, activity value is MIC = 256 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 256 uM	gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||Homo sapiens|||Homo sapiens [Human]|||Homo sapiens [Human]|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes	Helix	Moderate hemolytic activity (60% hemolysis at 50 μM)|||hRBC (4.47 (±0.35)% hemolysis at 175 ug/ml), Sheep RBC (HC₅₀=32 ± 0.68 ug/ml)|||hRBC (4.47 (±0.35)% hemolysis at 175 ug/ml), Sheep RBC = (HC50=32 ± 0.68 ug/ml)	"Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R. T.1996
 Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||Eur J Biochem
. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||28476579|||28408902, 30076860, 28400226, 27367675, 30076864, 30043322, 29022391, 31417238, 31396193, 31016971|||35254120|||28408902, 30076860, 28400226, 27367675, 30076864, 30043322, 29022391, 31417238, 31396193, 31016971||Refer 30076860||Refer PubMed ID: 30076864||Refer PubMed ID: 30043322|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed"	37	
FPDB00282	AP02850|||AP02850|||Laterosporulin 10	ACVNQCPDAIDRFIVKDKGCHGVEKKYYKQVYVACMNGQHLYCRTEWGGPCQL	Anti-microtitre plate Alamar blue assay: Active against microbial pathhogens such as M. tuberculosis strain H37Rv, activity value is LD50 = 0.5 uM||Anti-Mycobacterium tuberculosis H37Rv, activity value is MIC = 50||Anti-Staphylococcus aureus MTCC 1430, activity value is MIC = 50||Anti-Bacillus subtilis MTCC 121, activity value is MIC = 50||Anti-Escherichia coli MTCC 1610, activity value is MIC = 100 uM||Anti-Mycobacterium smegmatis mc2-155, activity value is MIC = 50||Anti-Mycobacterium tuberculosis H37Rv, activity value is MIC = 16 uM||Anti-Staphylococcus aureus MTCC 1430, activity value is MBC = 8 uM	Brevibacillus sp. strain SKDU10|||Brevibacillus sp. SKDU10	Bridge	Laterosporulin10 did not exhibit hemolytic activity at concentrations up to 40 μM, and the hemolysis rate was less than 20% at 100 μM.|||Brevibacillus sp. strain SKDU10|||Rabbit erythrocytes ( at NA , Rabbit erythrocytes (<20% Hemolysis at 100 uM	"Baindara P, Singh N, Ranjan M, Nallabelli N, Chaudhry V, Pathania GL, Sharma N, Kumar A, Patil PB, Korpole S.2016 Microbiology. 2016 Aug;162(8):1286-99. doi: 10.1099/mic.0.000316. PubMed|||2016 Aug;162(8):1286-1299. doi: 10.1099/mic.0.000316. Epub 2016 Jun 7.|||Biochem Biophys Res Commun
. 2016 Sep 16;478(2):924-8. doi: 10.1016/j.bbrc.2016.08.052. Epub 2016 Aug 9.|||27267959"	53	
FPDB00349	AP01161	GRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLR	Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Chemotactic||anti-TB||anti-sepsis||Synergistic AMPs||Hemolytic||Anticancer||a recombinant peptide showed activity in vitro against bacteria (S. typhimurium||L. monocytogenes||E. coli||and S. aureus)||fungi C. neoformans||C. albicans||and parasites L. major||and parasites L. major.	NK cells; T lymphocytes; Homo sapiens|||gammadelta T cells, NK cells; T lymphocytes; Homo sapiens|||gammadelta T cells, NK cells; T lymphocytes; Homo sapiens|||NK cells; T lymphocytes; Homo sapiens	Helix	. Eluted fractions were all individually assayed for hemolytic activity. The fractions with the highest hemolytic activity were pooled and concentrated for use.	Science. 1998 Oct 2;282(5386):121-5. Pub-Med.|||1998 Oct 2;282(5386):121-5. doi: 10.1126/science.282.5386.121.||see the ref|||1998 Oct 2;282(5386):121-5. doi: 10.1126/science.282.5386.121.|||Science. 1998 Oct 2;282(5386):121-5. Pub-Med.||see the ref|||Science. 1998 Oct 2;282(5386):121-5. Pub-Med.	74	
FPDB00939	AP00929|||AP00929|||Enterocin AS-48|||DRAMP00169	MAKEFGIPAAVAGTVINVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAW	Anti-Gram+ & Gram-||Antiparasitic||Anti-MRSA||anti-TB||Active against Gram-positive Bacillus||Staphylococcus (S. aureus||MRSA)||and Listeria and Gram-negative Salmonella||E. coli||etc.||Antibacterial ; Streptococcus faecalis S-47||Escherichia coli U-9||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	Enterococcus faecalis S-48; human microbiota:gut, symbiont bacteria|||Enterococcus faecalis S-48; human microbiota:gut, symbiont bacteria|||Enterococcus faecalis S-48|||Enterococcus faecalis S-48 (Gram-positive bacteria)	Helix	N/A	"Can J Microbiol
. 1986 Oct;32(10):765-71. doi: 10.1139/m86-141.|||1986 Oct;32(10):765-71. doi: 10.1139/m86-141.|||1986 Oct;32(10):765-71. doi: 10.1139/m86-141.|||https://pubmed.ncbi.nlm.nih.gov/3098396|||Res Microbiol. 1989 Jan;140(1):57-68.J Mol Biol. 2003 Nov 28;334(3):541-549.Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11221-6."	70	
FPDB01020	AP02249	"	
FISQIISTARI"	Anti-Gram+||Anti-MRSA||anti-TB||Anti-including S. aureus MSSA or MRSA, activity value is MIC = 0.25 ug/ml||Anti-E. faecalis, activity value is MIC = 0.5 ug/ml||Anti-penicillin-resistant S. pneumoniae, activity value is MIC < 0.003 ug/ml||Anti-S. pyogenes, activity value is MIC = 0.06 ug/ml||Anti-S. agalactiae, activity value is MIC = 0.12 ug/ml||Anti-B. anthracis, activity value is MIC <= 0.06 ug/ml||Anti-C. difficile, activity value is MIC = 0.005 ug/ml||Anti-P. acnes, activity value is MIC = 0.08 ug/ml||Anti-M. tuberculosis H37Rv, activity value is MIC = 0.125 ug/ml||Anti-H. influenzae, activity value is MIC = 4 ug/ml||Anti-M. catarrhalis, activity value is MIC = 2 ug/ml||Anti-P-aeruginosa, activity value is MIC > 32 ug/ml||Anti-and K-pneumoniae, activity value is MIC > 32 ug/ml	Eleftheria terrae, i-chip technology	Beta||Solid-state NMR observed the interaction of enduracididine with lipid II phosphate and established a beta-sheet structure, part of the large supramolecular fibrill (Shukla et al., 2022).	Eleftheria terrae, i-chip technology	"Nature
. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7.|||2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7.|||Nature. 2015 Jan 22;517(7535):455-9. Pub-Med."	11	
FPDB01097	AP03186	"	
SSAPCTIYASVSASISATASWGC"	Anti-Gram+||Anti-MRSA||anti-TB||Anti-ctive against S. simulans 22, activity value is MIC = 0.11 uM||Anti-S. aureus SG511 or SG511 DapR or clinical isolate MRSA MB5393, activity value is MIC = 0.22||Anti-M. tuberculosis H37Ra, activity value is MIC = 13.6 uM||Anti-B. subtilis 168, activity value is MIC = 3.4 uM||Anti-clinical isolates C. difficile RyC 11872343 toxigenic, activity value is MIC = 3.4 uM||Anti-S. simulans 22, activity value is MIC = 0.11 uM	Streptomyces cacaoi CA-170360	N/A	Streptomyces cacaoi CA-170360	"Angew Chem Int Ed Engl
. 2020 Jul 27;59(31):12654-12658. doi: 10.1002/anie.202005187. Epub 2020 Jun 15.|||. 2020 Jul 27;59(31):12654-12658. doi: 10.1002/anie.202005187. Epub 2020 Jun 15."	23	
FPDB01116	AP03317	"	
KRIRL"	Anti-Gram+ & Gram-||Anti-MRSA||anti-TB||Anti-B. subtilis 168 1A1, activity value is MIC = 4 ug/ml||Anti-E. faecium Com15, activity value is MIC = 8 ug/ml||Anti-S. aureus USA300, activity value is MIC = 8 ug/ml||Anti-E. coli DH5alpha, activity value is MIC = 16 ug/ml||Anti-K. pneumoniae ATCC 10031, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 17978, activity value is MIC = 32 ug/ml||Anti-E. cloacae ATCC 14037, activity value is MIC = 64 ug/ml||Anti-M. tuberculosis H37RV, activity value is MIC = 6 ug/ml	bioinformatic identified bacterial nonribosomal gene cluster, Bacillus thuringiensis plasmid BMB171, bacteria-derived, natural derivatives|||bioinformatic identified bacterial nonribosomal gene cluster, Bacillus thuringiensis plasmid BMB171, bacteria-derived, natural derivatives|||bioinformatic predicted bacterial nonribosomal gene cluster, Bacillus thuringiensis plasmid BMB171, bacteria-derived, natural derivatives	N/A	bioinformatic predicted bacterial nonribosomal gene cluster, Bacillus thuringiensis plasmid BMB171, bacteria-derived, natural derivatives	"J Am Chem Soc
. 2020 Aug 19;142(33):14158-14168. doi: 10.1021/jacs.0c04376. Epub 2020 Aug 11.|||2020 Aug 19;142(33):14158-14168. doi: 10.1021/jacs.0c04376. Epub 2020 Aug 11"	5	
FPDB01148	AP03632	"	
FLKSNALL"	Anti-Gram+ & Gram-||Anti-MRSA||anti-TB||Anti-S. aureus susceptible and resistant strains NCTC 8325 NRS108 NRS71 MRSA Mu50 VISA, activity value is MIC = 0.125||Anti-S. epidermidis ATCC 35982 or NRS8, activity value is MIC = 0.5 ug/ml||Anti-S. haemolyticus NRS9 or NRS69, activity value is MIC = 0.5||Anti-E. faecium BM4147 VRE, activity value is MIC = 0.5||Anti-B. subtilis 1A1 or 168, activity value is MIC = 1||Anti-B. anthracis Sterne, activity value is MIC = 0.25 ug/ml||Anti-S. pneumoniae ATCC10813, activity value is MIC = 0.25||Anti-S. pyogenes ATCC19615, activity value is MIC = 0.25||Anti-S. warneri NRS138, activity value is MIC = 1 ug/ml||Anti-M. smegmatis MC2 155, activity value is MIC = 2 ug/ml||Anti-M. tuberculosis MC2 6020, activity value is MIC = 0.5||Anti-H. influenzae SJ7, activity value is MIC = 2 ug/ml||Anti-E. coli K12, activity value is MIC = 64 ug/ml||Anti-and P.aeruginosa PA-01, activity value is MIC > 128 ug/ml	Eleftheria terrae ssp. Carolina|||Eleftheria terrae ssp. carolina	Beta	"The document does not mention hemolytic values related to the antimicrobial peptide clovibactin (such as hemolysis rate, HC₅₀, etc.) and only indirectly demonstrates its low toxicity to eukaryotic cells through other safety experiments. Specific information is as follows:

1. Indirect safety evidence related to hemolysis

- Mammalian cytotoxicity experiments:
At the highest tested concentration (100 µg/ml), clovibactin showed no significant cytotoxicity to mouse embryonic fibroblasts (NIH/3T3) and human liver cancer cells (HepG2) (cell viability >80%). Cell viability was measured using the CellTiter 96 AQueous One Solution kit, and absorbance at 490 nm was used to calculate cell survival, confirming its safety to eukaryotic cells (no direct hemolysis data, but low cytotoxicity indirectly reflects a low risk of damage to mammalian cell membranes).

- Specificity of action on bacterial cell membranes:
Clovibactin targets the pyrophosphate groups of bacterial cell wall precursors (C₅₅PP, lipid I, lipid II) and forms supramolecular fibers only on bacterial membranes, without damaging mammalian cell membranes. Experiments confirmed that it does not cause rapid bacterial membrane permeabilization (e.g., SYTOX Green penetration assay negative) or depolarization (DiSC₂(5) fluorescence assay negative), and it does not affect the localization of the Bacillus subtilis cell division protein MinD (MinD localization depends on membrane potential; disruption of membrane potential would cause delocalization). This further indicates that it does not have a similar destructive effect on eukaryotic cell membranes, suggesting extremely low hemolytic potential, although direct hemolysis data are lacking.

2. Additional notes

- The document focuses on clovibactin’s antibacterial mechanism (targeting bacterial cell wall precursors, forming supramolecular fibers) and in vitro and in vivo antibacterial activity (e.g., reducing bacterial load in a mouse thigh infection model) and did not include red blood cell hemolysis experiments; therefore, direct hemolysis values such as hemolysis rate and HC₅₀ are not available.

- Its low toxicity (non-toxic to mammalian cells, not damaging eukaryotic cell membranes) is consistent with the safety characteristics of similar low-hemolytic antimicrobial peptides (e.g., teixobactin), allowing indirect inference that its hemolytic risk is extremely low, though future hemolysis experiments are needed for confirmation.|||Eleftheria terrae ssp. carolina"	"Cell
. 2023 Sep 14;186(19):4059-4073.e27. doi: 10.1016/j.cell.2023.07.038. Epub 2023 Aug 22.|||2023 Sep 14;186(19):4059-4073.e27. doi: 10.1016/j.cell.2023.07.038. Epub 2023 Aug 22.|||Cell. 2023 Sep 14;186(19):4059-4073.e27. doi: 10.1016/j.cell.2023.07.038. Pub-Med.|||Cell. 2023 Sep 14;186(19):4059-4073.e27. doi: 10.1016/j.cell.2023.07.038. Pub-Med.|||Cell. 2023 Sep 14;186(19):4059-4073.e27. doi: 10.1016/j.cell.2023.07.038. Pub-Med."	8	
FPDB01448	AP01728|||DRAMP00230	GSQLVYREWVGHSNVIKP	Active against Gram-positive M. smegmatis and M. tuberculosis.||Antimicrobial||Antibacterial||Anti-Gram+	Rhodococcus jostii K01-B0171, Yunnan, China, Asia|||Rhodococcus jostii K01-B0171 (Gram-positive bacteria)	Beta	N/A	"2006 Jun 14;128(23):7486-91. doi: 10.1021/ja056780z.|||J Am Chem Soc
. 2006 Jun 14;128(23):7486-91. doi: 10.1021/ja056780z.|||J Am Chem Soc. 2006 Jun 14;128(23):7486-7891."	18	
FPDB01449	AP01729|||DRAMP00231	GSQLVYREWVGHSNVIKGPP	Active against Gram-positive M. smegmatis and M. tuberculosis.||Antimicrobial||Antibacterial||Anti-Gram+	Rhodococcus jostii K01-B0171, Yunnan, China, Asia|||Rhodococcus jostii K01-B0171 (Gram-positive bacteria)	N/A	N/A	"2006 Jun 14;128(23):7486-91. doi: 10.1021/ja056780z.|||J Am Chem Soc
. 2006 Jun 14;128(23):7486-91. doi: 10.1021/ja056780z.|||J Am Chem Soc. 2006 Jun 14;128(23):7486-7891."	20	
FPDB01450	AP02067	QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGPTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYR	Initially implicated in angiogenesis (angiogenic) and human cancer with weak RNase activity (ribonuclease activity). It is also established that this peptide is active against C. albicans and S. pneumoniae. Another paper: this peptide also specifically inhibited M. tuberculosis (Mtb||anti-TB).	liver, intestine, skin, Homo sapiens	Combine Helix and Beta structure	N/A	Nat Immunol. 2003 Mar;4(3):269-73	95	
FPDB01451	AP02069	QNERYEKFLRQHYDAKPNGRDDRYCESMMKERKLTSPCKDVNTFIHGTKKNIRAICGKKGSPYGENFRISNSPFQITTCTHSGASPRPPCGYRAFK	Activity: Active against E. faecalis||L. monocytogenes (both Gram-positive pathogens declined by >99% after a 2 h exposure to 1 uM of Ang4). Inhibited intestinal commensal Gram- B. thetaiotaomicron by 30% (1 uM). No effect on E-coli K12 and L-innocua (at 10 uM). Also angiogenic with RNas	Paneth cells, small intestine, Mus musculus	Combine Helix and Beta structure	N/A	2003 Mar;4(3):269-73. doi: 10.1038/ni888. Epub 2003 Jan 27.	96	
FPDB01452	AP02073	KPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKYPNCR	Has ribonuclease activity as well.	keratinocytes, Skin (e.g. hair follicle), urinary tract, Homo sapiens, including pre-term and term infants	Combine Helix and Beta structure	N/A	2002 Nov 29;277(48):46779-84. doi: 10.1074/jbc.M207587200. Epub 2002 Sep 18	92	
FPDB01453	AP02376	GLRRLFADQLVGRRNI	Active against both growing and dormant mycobacteria||including drug-resistant M. tuberculosis (anti-TB).	an extract, Lentzea kentuckyensis sp	Beta||nonHelixbeta	an extract, Lentzea kentuckyensis sp	2014 Apr 24;21(4):509-518. doi: 10.1016/j.chembiol.2014.01.014. Epub 2014 Mar 27.|||Chem Biol. 2014 Apr 24;21(4):509-18. doi: 10.1016/j.chembiol.2014.01.014. PubMed	16	
FPDB01454	AP02439|||AP02439|||CAMPSQ1879|||CAMPSQ1880|||CAMPSQ1881|||DRAMP00202	SCTTCVCTCSCCTT	: Active against human malaria parasite P. falciparum (LC50 0.035 uM). Also active against M. tuberculosis (anti-TB)   and hepatitis C virus  ;||Active against human malaria parasite P. falciparum (LC50 0.035 uM). Also active against M. tuberculosis (anti-TB)   and hepatitis C virus  ;||Antimicrobial||Antibacterial||Anti-Gram+||Antiviral||Antiparasitic||anti-TB||Antimalarial	2733, from a French red smear cheese|||Bacillus cereus|||Bacillus badius|||Bacillus cereus (strain ATCC 14579 / DSM 31)|||Bacillus cereus); also Bacillus badius|||Staphylococcus epidermidis strain 115; Staphylococcus equorum WS 2733, from a French red smear cheese	N/A	Staphylococcus epidermidis strain 115; Staphylococcus equorum WS 2733, from a French red smear cheese	2014 Dec;196(24):4344-50. doi: 10.1128/JB.02243-14. Epub 2014 Oct 13.||Degiacomi G et al., 2016||Lee M et al., 2016|||J Bacteriol. 2014 Dec;196(24):4344-50. PubMed||Degiacomi G et al., 2016||Lee M et al., 2016|||J Antibiot (Tokyo). 1976 Apr;29(4):366-374.J Antibiot (Tokyo). 1981 Sep;34(9):1126-1136.|||J Bacteriol. 2014 Dec;196(24):4344-50. PubMed	14	
FPDB01455	AP02568|||AP02568|||D-Brevinin CTcu5	LIAGLAANFLPQILCKIARKC	Anti-B. coagulans ATCC 7050, activity value is MIC = 6.25 ug/ml||Anti-E. coli MG1655, activity value is MIC = 7 ug/ml||Anti-and V. cholerae, activity value is MIC = 15 ug/ml||Antibacterial	skin secretions, the Indian bicoloured frog, Clinotarsus curtipes, Asia|||Clinotarsus curtipes,Odorrana andersonii,Odorrana grahami	Helix	"B1CTcu1：1%。

- B1CTcu2：17.8%。

- B1CTcu3：45%。

- B1CTcu4：54.8%。

- B1CTcu5：37.5%。|||skin secretions, the Indian bicoloured frog, Clinotarsus curtipes, Asia||As to hemolytic activity, Hc-CATH yielded a hemo-lysis of 5.25%, at the same concentration of 200 ␮g/ml.Hc-CATHBinds to Bacteria and Induces Alteration ofMicro-bial Membrane Morphology—Attraction and attachment tomicrobial surfaces is regarded as the first step for AMP-medi-ated cell killing (10).|||Rabbit erythrocytes (38% Hemolysis at 200 ug/ml, Human erythrocytes (40% Hemolysis at 200 ug/ml, Human embryonic kidney HEK293 cells (50% Cytotoxicity at >100 ug/ml, Human erythrocytes (37% Hemolysis at 200 ug/ml, Human erythrocytes (40.22% Hemolysis at 200 ug/ml"	2014 Feb:97:144-51. doi: 10.1016/j.biochi.2013.10.005. Epub 2013 Oct 24.||Abraham et al., 2020|||Biochimie. 2014 Feb;97:144-51. PubMed||Abraham et al., 2020|||24161537, 25997127, 32679168	21	
FPDB01456	AP02603|||AP02603|||VpAmp1.0|||VpAmp1.0|||AP02603	LPFFLLSLIPSAISAIKKI	Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-TB||Hemolytic||Antibacterial ; Synthetic construct||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 2.5 uM||Anti-Streptococcus agalactiae, activity value is MIC = 2.5 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 24 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 2.5 uM||Anti-Candida albicans, activity value is MIC = 6.25 uM||Anti-Candida glabrata, activity value is MIC > 50 uM||Anti-Mycobacterium tuberculosis H37Rv, activity value is MIC = 17.4||Anti-Mycobacterium tuberculosis, activity value is MIC = 4.8	venom glands, Vaejovis punctatus, Mexico, North America|||Synthetic construct|||venom glands, Vaejovis punctatus, Mexico, North America	Helix	venom glands, Vaejovis punctatus, Mexico, North America||The cytotoxicity of the peptides was assayed against normal human red blood cells, measuring the extent of hemolysis exerted by different concentrations of the peptides (Figure 3 and Table 3). The only highly hemolytic peptide was VpAmp1.0, eliciting strong hemolysis at relatively low concentrations. The hemolytic effect is reduced in the order VpAmp1.0 >> VpAmp1.1 > VpAmp2.1 > VpAmp2.0, with concentrations producing 50% hemolysis (HC50) of roughly 9, 34, 104 and 171 uM, respectively.|||Staphylococcus aureus ATCC 25923[MIC = 2.5 uM], Streptococcus agalactiae[MIC = 2.5 uM], Escherichia coli ATCC 25922[MIC = 24 uM], Pseudomonas aeruginosa ATCC 9027[MIC = 2.5 uM], Candida albicans[MIC = 6.25 uM], Candida glabrata[MIC >50 uM], Mycobacterium tuberculosis H37Rv[MIC = 17.4+-6.4 uM], Mycobacterium tuberculosis[MIC = 4.8+-1.5 uM]||Human erythrocytes (50% Hemolysis at 9.2+-0.3 uM|||Human erythrocytes (50% Hemolysis at 9.2+-0.3 uM|||Human erythrocytes (50% Hemolysis at 9.2+-0.3 uM|||The only highly hemolytic peptide was VpAmp1.0, eliciting strong hemolysis at relatively low concentrations. The hemolytic effect is reduced in the order VpAmp1.0 >> VpAmp1.1 > VpAmp2.1 > VpAmp2.0, with concentrations producing 50% hemolysis (HC50) of roughly 9, 34, 104 and 170 uM, respectively.	"2015 Nov:73:51-9. doi: 10.1016/j.peptides.2015.08.014. Epub 2015 Sep 4.|||Peptides. 2015 Sep 4;73:51-59. PubMed|||https://pubmed.ncbi.nlm.nih.gov/26352292|||26352292|||Peptides
. 2015 Nov:73:51-9. doi: 10.1016/j.peptides.2015.08.014. Epub 2015 Sep 4|||Peptides. 2015 Sep 4;73:51-59. PubMed"	19	
FPDB01457	AP02604|||AP02604|||VpAmp2.0|||VpAmp2.0|||AP02604	FWGFLGKLAMKAVPSLIGGNKSSSK	Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-TB||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 10 uM||Anti-Streptococcus agalactiae, activity value is MIC = 15 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 24 uM||Anti-Pseudomonas aeruginosa ATCC 9027, activity value is MIC = 15 uM||Anti-Candida albicans, activity value is MIC = 12.5 uM||Anti-Candida glabrata, activity value is MIC = 50 uM||Anti-Mycobacterium tuberculosis H37Rv, activity value is MIC = 21.4||Anti-Mycobacterium tuberculosis, activity value is MIC = 30.5	venom glands, Vaejovis punctatus, Mexico, North America|||Synthetic construct|||Synthetic construct|||venom glands, Vaejovis punctatus, Mexico, North America|||venom glands, Vaejovis punctatus, Mexico, North America	Helix	venom glands, Vaejovis punctatus, Mexico, North America||Human red blood cells were used to evaluate the hemolytic capabil- ity of defensin-TK. It exerted a low hemolytic activity on human red cells. At concentrations of 200, 100 and 50 ug/ml, the hemolysis ratio of human red cells was 6.2%, 2.7% and 1.5%, respectively.|||Human erythrocytes (50% Hemolysis at 167+-22.5 uM|||Human erythrocytes (50% Hemolysis at 167+-22.5 uM|||The only highly hemolytic peptide was VpAmp1.0, eliciting strong hemolysis at relatively low concentrations. The hemolytic effect is reduced in the order VpAmp1.0 >> VpAmp1.1 > VpAmp2.1 > VpAmp2.0, with concentrations producing 50% hemolysis (HC50) of roughly 9, 34, 104 and 170 uM, respectively.	"2015 Nov:73:51-9. doi: 10.1016/j.peptides.2015.08.014. Epub 2015 Sep 4.|||Peptides. 2015 Sep 4;73:51-59. PubMed|||26352292|||26352292|||Peptides
. 2015 Nov:73:51-9. doi: 10.1016/j.peptides.2015.08.014. Epub 2015 Sep 4.|||Peptides. 2015 Sep 4;73:51-59. PubMed"	25	
FPDB01458	AO02688|||AP02688	VPSLPLVPLG	Anti-Gram+ & Gram-||Enzyme inhibitor||anti-TB	Streptomyces	N/A	Streptomyces	2015 Jun 5;348(6239):1106-12. doi: 10.1126/science.aaa4690.|||Science. 2015 Jun 5;348(6239):1106-12. PubMed	10	
FPDB01459	AP03101|||AP03101|||HBD10	RECRIGNGQCKNQCHENEIRIAYCIRPGTHCCLQQ	Anti-S. aureus ATCC 25923, activity value is MIC = 25 uM||Anti-M. tuberculosis H37Rv, activity value is MIC = 11.8 uM||Anti-and M. tuberculosis MDR, activity value is MIC = 5.9 uM||Antibacterial	Homo sapiens	Bridge	Homo sapiens||The average absorbance of samples treated with deionized water is defined as 100% hemolysis|||Human RBCs [Hemolysis % = 1.8]	"2020 Jan;88(1):175-186. doi: 10.1002/prot.25785. Epub 2019 Jul 30.|||Proteins
. 2020 Jan;88(1):175-186. doi: 10.1002/prot.25785. Epub 2019 Jul 30.|||31325337"	35	
FPDB01460	AP03102|||AP03102|||HBDconsensus	KKCWNGGRCRKKCKENEKPIGYCRNGKKCCVN	Anti-S. aureus ATCC25923, activity value is MIC = 12.5 uM||Anti-E. coli ATCC25922, activity value is MIC = 25 uM||Anti-and M. tuberculosis H37Rv or MDR, activity value is MIC = 8.8||Antibacterial	mammal defensin analog, a consensus beta defensin sequence, peptide library analysis|||Synthetic construct	Combine Helix and Beta structure	mammal defensin analog, a consensus beta defensin sequence, peptide library analysis||The average absorbance of samples treated with deionized water is defined as 100% hemolysis|||Human RBCs [Hemolysis % = 1.6]	"2020 Jan;88(1):175-186. doi: 10.1002/prot.25785. Epub 2019 Jul 30.|||Proteins
. 2020 Jan;88(1):175-186. doi: 10.1002/prot.25785. Epub 2019 Jul 30.|||31325337"	32	
FPDB01461	AP03162|||AP03162|||Bacteriocin Pantocin wh-1	VMWCYVFGYGFNCAVW	Anti-M. tuberculosis, activity value is MIC = 7.5 ug/ml||Anti-M. smegmatis, activity value is MIC = 2.5 ug/ml||Anti-Mycobacterium smegmatis mc2-155, activity value is MIC = 2.5 ug/ml||Anti-Mycobacterium smegmatis mc2-155, activity value is MBC = 5 ug/ml||Anti-Mycobacterium tuberculosis H37Ra, activity value is MIC = 7.5 ug/ml||Anti-Mycobacterium bovis BCG, activity value is MIC = 7.5 ug/ml	Pantoea dispersa W18, from soil|||Pantoea dispersa W18	N/A	Pantoea dispersa W18, from soil	"2020 Jan 23;25(3):485. doi: 10.3390/molecules25030485.|||Molecules
. 2020 Jan 23;25(3):485. doi: 10.3390/molecules25030485.|||31979296|||Molecules
. 2020 Jan 23;25(3):485. doi: 10.3390/molecules25030485."	16	
FPDB01462	AP03627	AAHLPAEFTPAVHASLDKFLASVSTVLTSKYR	radial diffusion assays: freshly solubilized peptide was active against E. faecium||L. monocytogenes||A. baumannii||P. aeruginosa in a concentration-dependent manner. Did not inhibit S.aureus||K.pneumoniae||and E.coli (bacteriostatic to this strain) till 1000 ug/ml. Both freshly solubilized and fibril forms kill L. monocytogenes and M. tuberculosis||where freshly solubilized and acidic pH 4.5 are preferred for L. monocytogenes. Also||AG-HBA(111–142) inhibited wildtype||acyclovir-resistant HSV-1 and HSV-2 isolates as well as HCMV and MeV in a dose-dependent manner||with IC50 values around 100 ug/ml.||Anti-Gram+ & Gram-||Antiviral||anti-TB	Homo sapiens	N/A	Homo sapiens||No significant hemolytic activity was observed at a concentration as high as 1000 ug/ml.|||No significant hemolytic activity was observed at a concentration as high as 1000 ug/ml.	2023 May 17;80(6):151. doi: 10.1007/s00018-023-04795-8.|||Cell Mol Life Sci. 2023 May 17;80(6):151. doi: 10.1007/s00018-023-04795-8. Pub-Med.|||Cell Mol Life Sci. 2023 May 17;80(6):151. doi: 10.1007/s00018-023-04795-8. Pub-Med.|||Cell Mol Life Sci. 2023 May 17;80(6):151. doi: 10.1007/s00018-023-04795-8. Pub-Med.	32	
FPDB01463	AP03943	KAINTFIHGNKISIKAI	inhibited M. tuberculosis 78% at 100 uM (anti-TB). It displayed dose-dependent inhibitory activity against E. coli||K. pneumoniae||and P. aeruginosa (inhibition zone).||and P. aeruginosa (inhibition zon	computationally identified and changed based on a fragment of human Angiogenin, animal-derived, natural derivative	N/A	N/A	2021 Jan 18:11:618278. doi: 10.3389/fmicb.2020.618278. eCollection 2020.|||Front Microbiol. 2021 Jan 18;11:618278. doi: 10.3389/fmicb.2020.618278. PubMed	17	
FPDB01464	AP05623	GFGRIKADQLVGRLIP	Anti-M. tuberculosis mc26020 or H37Rv, activity value is MIC = 0.06 ug/ml||Anti-M. avium, activity value is MIC < 0.1 ug/ml||Anti-M. abscessus, activity value is MIC = 1 ug/ml||Anti-M. paratuberculosis, activity value is MIC < 0.1 ug/ml||Anti-S.aureus, activity value is MIC > 128 ug/ml||Anti-Gut symbionts B-fragilis, activity value is MIC > 64 ug/ml||Anti-L. reuteri, activity value is MIC = 8 ug/ml	Kitasatospora sp.	N/A	N/A	"mBio
. 2020 Aug 4;11(4):e01516-20. doi: 10.1128/mBio.01516-20."	16	
FPDB01465	AP05624	VIITVLLVRAVLATVRIERV	Anti-M. tuberculosis mc26020 or H37Rv, activity value is MIC = 0.03 ug/ml||Anti-M. avium, activity value is MIC < 0.1 ug/ml||Anti-M. abscessus, activity value is MIC = 0.5 ug/ml||Anti-M. paratuberculosis, activity value is MIC = 0.1||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-Gut symbionts B. fragilis, activity value is MIC = 32 ug/ml||Anti-L. reuteri, activity value is MIC = 2 ug/ml	Streptomyces sp.	N/A	N/A	2020 Aug 4;11(4):e01516-20. doi: 10.1128/mBio.01516-20.	20