Unique_ID	Origin_ID	Sequence	Activity	Source	Structure	Hemolysis	Reference	Length	Stereo
FPDB00002	AP00026|||AP00026|||Lactotransferrin precursor|||LFcinB|||DRAMP02840	FKCRRWQWRMKKLGAPSITCVRRAF	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||anti-sepsis||Synergistic AMPs||Anticancer||Anti-E. coli IID-861, activity value is MIC = 2 uM||Anti-K. pneumoniae JCM1662T, activity value is MIC = 3 uM||Anti-P. aeruginosa IFO-3446, activity value is MIC = 3 uM||Anti-S. aureus JCM-2151 or MRSA, activity value is MIC = 2 uM||Anti-L. monocytogenes IDF-1 b, activity value is MIC = 0.3 uM||MRSA||Antibacterial||Anti-Streptomyces scabiei S58, activity value is IC50 = 1.222||Anti-Escherichia coli L361, activity value is MIC = 4 uM||Anti-Salmonella Salford, activity value is MIC = 4 uM||Anti-Escherichia coli O:9, activity value is MIC = 6 uM||Anti-Pseudomonas fluorescens, activity value is MIC = 10 uM||Anti-Listeria monocytogenes, activity value is MIC = 2 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Bacillus cereus, activity value is MIC = 6 uM||Anti-ctive against E. coli IID-861, activity value is MIC = 2 uM	cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine)	Beta||Beta strand (4 strands; 8 residues)	E.coli ( MIC = 12.5 ug/ml)	"J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.|||Bellamy W, Takase M, Wakabayashi H, Kawase K, Tomita M.1992
 J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol. 1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.|||1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol
. 1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.|||9521752 , 8980754|||35213576|||Ref.8980754|||1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012"	25	
FPDB00003	AP00028|||Aborycin|||DRAMP00205|||AP00028|||DRAMP00205|||Rp 71955	CLGIGSCNDFAGCGYAVVCFW	Antiviral||Anti-HIV||inhibited the HIV-1 aspartyl protease (IC50||35 ug/ml) a||Anti-S.aureus, activity value is MIC = 8 ug/ml||Anti-Methicillin-resistant S.aureus, activity value is MIC = 8 ug/ml||Anti-Methicillin-resistant S.epidermidis, activity value is MIC = 128 ug/ml||Anti-S.aureus Sau 29213, activity value is MIC = 8 ug/ml||Anti-S.aureus Sau 1862, activity value is MIC = 16 ug/ml||Anti-S.aureus Sau 669, activity value is MIC = 32 ug/ml||Anti-S.aureus Sau 991, activity value is MIC = 16 ug/ml||Anti-S.aureus 16339, activity value is MIC = 16 ug/ml||Anti-S.aureus 6917, activity value is MIC = 16 ug/ml||Anti-S.aureus 16162, activity value is MIC = 64 ug/ml||Anti-S.aureus 718306, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus 745524, activity value is MIC = 16 ug/ml||Anti-Staphylococcus aureus GDQ6P012P, activity value is MIC = 64 ug/ml||Anti-E.faecalis ATCC 29212, activity value is MIC = 8 ug/ml||Anti-E.gallinarum 5F52C, activity value is MIC = 0.5 ug/ml||Anti-B. thuringiensis, activity value is MIC = 2 ug/ml||Anti-A. baumannii ATCC 19606, activity value is MIC = 128 ug/ml||Antimicrobial||Antiviral ; HIV-1	Streptomyces strains AA3891|||Streptomyces sp. SCSIO ZS0098|||Streptomyces sp. (strain SP9440) (Gram-positive bacteria)|||Streptomyces strains AA3891|||Streptomyces sp. (strain SP9440) (Gram-positive bacteria)|||Actinomycete Sp9440	Beta||Beta strand	No hemolysis information or data found in the reference(s) presented in this entry	J Antibiot (Tokyo). 1993 Nov;46(11):1756-7. 1993 Nov;46(11):1756-7. doi: 10.7164/antibiotics.46.1756.PubMed.|||30795576|||J Antibiot (Tokyo). 1993 Nov;46(11):1756-1757.Biochemistry. 1994 Jan 11;33(1):42-50.|||1993 Nov;46(11):1756-7. doi: 10.7164/antibiotics.46.1756.|||J Antibiot (Tokyo). 1993 Nov;46(11):1756-1757.Biochemistry. 1994 Jan 11;33(1):42-50.|||8286361	21	
FPDB00004	AP00058|||1649|||1653|||1657|||1661|||AP00058|||Maximin 1|||DRAMP01107|||Maximin 1|||AP00058|||AP00058|||DRAMP01107|||Maximin 1	GIGTKILGGVKTALKGALKELASTYAN	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Spermicidal||Anti-HIV||Hemolytic||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 19.5 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 19.5 ug/ml||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 19.5 ug/ml||Anti-B. megatherium, activity value is MIC = 19.5 ug/ml||Anti-K. pneumoniae, activity value is MIC = 9 ug/ml||Anti-B. dysenterium, activity value is MIC = 2.7 uM||Anti-C. albicans ATCC2002, activity value is MIC = 3 uM||activity value is IC50 = 15.3 ug/ml||activity value is IC50 = 24.3 ug/ml||activity value is IC50 = 20.5 ug/ml||activity value is IC50 = 35.4 ug/ml||Anti-Escherichia coli ATCC25922, activity value is MIC = 9 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 4.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 9 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 4.5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 19.5 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 9 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 19.5 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 19.5 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 19.5 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 2.7 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 3 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima	Helix	"No hemolytic activity (0% hemolysis at 100 µM)|||In Document 3 (Eur. J. Immunol. 2005), the specific hemolytic values of the maximin family and maximin H family antimicrobial peptides in the skin secretions of the large-webbed bell toad (Bombina maxima) are not explicitly mentioned.|||No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml.

Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells"	"Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.
 Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides
. 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed."	27	L
FPDB00005	AP00060|||1650|||1654|||1658|||1662|||AP00060|||Maximin 3|||DRAMP01109|||Maximin 3|||AP00060|||DRAMP01109|||AP00060|||DRAMP01109|||Maximin 3	GIGGKILSGLKTALKGAAKELASTYLH	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Spermicidal||Anti-HIV||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 0.9 ug/ml||Anti-S. aureus ATCC2592, activity value is MIC = 3.1 ug/ml||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 1.5 ug/ml||Anti-B. megatherium, activity value is MIC = 0.9 ug/ml||Anti-B. dysenterium, activity value is MIC = 0.9 ug/ml||Anti-K. pneumoniae, activity value is MIC = 3.1 ug/ml||Anti-and C. albicans ATCC2002, activity value is MIC = 15 uM||activity value is IC50 = 11.4 ug/ml||activity value is IC50 = 25.2 ug/ml||activity value is IC50 = 28 ug/ml||activity value is IC50 = 18 ug/ml||Anti-and T24, activity value is IC50 = 11||Anti-Escherichia coli ATCC25922, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 2 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 4 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 2 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 0.9 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 3.1 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 1.5 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 0.9 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 0.9 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 15 ug/ml||Anti-HIV-1, activity value is IC50 = 11.4 ug/ml||activity value is EC50 = 1.5 ug/ml||Anti-Cancer cell lines: C8166, activity value is IC50 = 11.4 ug/ml||Anti-Molt-4, activity value is IC50 = 25.2 ug/ml||Anti-BIU-87, activity value is IC50 = 28 ug/ml||Anti-T24, activity value is IC50 = 18 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima	Helix	"No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml.

Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells|||human RBC: HC50 >250 ug/ml, less hemo.lytic. toxic to cell IC50 11.4 ug/ml, anti-HIV-1 EC50 1.5 ug/ml, cell selectivity index 7.6 (Lai R et al., 2012)."	"Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.
 Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides
. 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed."	27	L
FPDB00006	AP00061|||AP00061|||Maximin 4|||DRAMP01110|||Maximin 4|||AP00061|||DRAMP01110|||AP00061|||DRAMP01110|||Maximin 4	GIGGVLLSAGKAALKGLAKVLAEKYAN	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Spermicidal||Anti-HIV||Anticancer||Anti-E. coli ATCC25922, activity value is MIC = 2.7 uM||Anti-S. aureus ATCC2592, activity value is MIC = 2.7 uM||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 2.7 uM||Anti-B. megatherium, activity value is MIC = 1.5 uM||Anti-B. dysenterium, activity value is MIC = 2.7 uM||Anti-K. pneumoniae, activity value is MIC = 15 uM||Anti-C. albicans ATCC2002, activity value is MIC = 15 uM||Anti-and P.uticale IFFI2001 . active against cancer cells C8166 and Molt-4, activity value is IC50 = 24||Anti-Escherichia coli ATCC25922, activity value is MIC = 20 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 10 ug/ml||Anti-Bacillus pyocyaneus CMCCB1010, activity value is MIC = 20 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 5 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.7 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 15 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 2.7 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 2.7 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 1.5 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 2.7 ug/ml||Anti-Candida albicans ATCC 2002, activity value is MIC = 15 ug/ml||Anti-HIV-1, activity value is IC50 = 24.2 ug/ml||activity value is EC50 = 21.9 ug/ml||Anti-Cancer cell lines: C8166, activity value is IC50 = 24.2 ug/ml||Anti-Molt-4, activity value is IC50 = 35.4 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima	Helix	"No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml.

Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells|||toxic to cell IC50 24.2 ug/ml, similar to EC50 against HIV-1 (Lai R et al., 2012)."	"Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.
 Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides
. 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.  Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed."	27	
FPDB00007	AP00062|||1652|||1656|||1660|||1664|||AP00062|||Maximin 5|||DRAMP01111|||Maximin 5|||AP00062|||DRAMP01111|||AP00062|||DRAMP01111|||Maximin 5	SIGAKILGGVKTFFKGALKELASTYLQ	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anticancer||Anti-S. aureus ATCC2592, activity value is MIC = 3.6 uM||Anti-B. pyocyaneus CMCCB10104, activity value is MIC = 7.2 uM||Anti-B. megatherium, activity value is MIC = 12 uM||Anti-B. dysenterium, activity value is MIC = 12 uM||Anti-K. pneumoniae, activity value is MIC = 3.6 uM||Anti-C. albicans ATCC2002, activity value is MIC = 1.2 uM||Anti-A. flavus IFFI4015, activity value is MIC = 12 ug/ml||Anti-and P. uticale IFFI2001, activity value is MIC = 12 ug/ml||activity value is IC50 = 34.4 ug/ml||activity value is IC50 > 50 ug/ml||IC50 =>50 ug/ml||IC50=>50 ug/ml||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 3.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB10104, activity value is MIC = 7.2 ug/ml||Anti-Bacillus megatherium, activity value is MIC = 12 ug/ml||Anti-Bacillus dysenteriae, activity value is MIC = 12 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 3.6 ug/ml||Anti-Candida albicans ATCC2002, activity value is MIC = 1.2 ug/ml||Anti-Aspergillus flavus IFFI4015, activity value is MIC = 12 ug/ml||Anti-Penicillium uticale IFFI2001, activity value is MIC = 12 ug/ml||Anti-HIV-1, activity value is MIC = 34.4 ug/ml||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 3.6 ug/ml||Anti-Bacillus pyocyaneus CMCCB 10104, activity value is MIC = 7.2 ug/ml||Anti-Aspergillus flavus IFFI 4015, activity value is MIC = 12 ug/ml||Anti-Penicillium uticale IFFI 2001, activity value is MIC = 12 ug/ml||Anti-HIV-1, activity value is IC50 = 34.4 ug/ml||activity value is EC50 = 39.8 ug/ml||Anti-Cancer cell lines: C8166, activity value is IC50 = 34.4 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima [Giant fire-bellied toad]|||Chinese red belly toad, Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima , Yunnan, China, Asia|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)|||Bombina maxima	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||Maximins show almost no hemolytic activity against red blood cells even at a concentration as high as 50 µg/ml.

Maximin H peptides can lyse 90-100% of rabbit red blood cells at a concentration of 50 µg/ml.|||[Ref:11835991]Little hemolytic activity at 50 ug/ml against red blood cells|||IC50 34.4 ug/ml, against HIV-1 cell selectivity index 0.88 (Lai R et al., 2012). Updated 2/2012; 12/2015; 11/2024 GW."	"Peptides 2002; 23:427-435. PubMed.|||Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.
 Peptides 2002; 23:427-435. PubMed.|||Peptides 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Peptides
. 2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||11835991|||Eur J Immunol. 2005 Apr;35(4):1220-9.||Ref.11835991|||11835991|||Peptides 2002; 23:427-435. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||2002 Mar;23(3):427-35. doi: 10.1016/s0196-9781(01)00641-6.|||Eur J Immunol. 2005 Apr;35(4):1220-9.Peptides. 2002 Mar;23(3):427-435.|||https://pubmed.ncbi.nlm.nih.gov/11835991|||Peptides 2002; 23:427-435. PubMed."	27	L
FPDB00008	AP00121|||DRAMP30312|||AP00121|||DRAMP30312	GLMDTVKNVAKNLAGHMLDKLKCKITGC	"Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-S. aureus, activity value is MIC = 50 uM||Anti-E. coli, activity value is MIC = 13 uM||Anti-and C. albicans, activity value is MIC = 67 uM||Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(90% inhibition at 500 uM);
Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(99% inhibition at 50 uM)."	North American frog, Rana pipiens , or Lithobates pipiens, ALSO: the Oregon spotted frog Rana pretiosa|||Rana pipiens (Northern leopard frog)|||North American frog, Rana pipiens , or Lithobates pipiens, ALSO: the Oregon spotted frog Rana pretiosa|||Rana pipiens (Northern leopard frog)	N/A	N/A	"Eur J Biochem. 2000 Feb;267(3):894-900. PubMed|||Eur J Biochem. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Comparative Study Eur J Biochem
. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Ref.11601906|||2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Virology. 2001 Sep 30;288(2):351-7.||Ref.11601906|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed."	28	
FPDB00009	AP00139|||1317|||1318|||1319|||1320|||1329|||1330|||1331|||1332|||1341|||1342|||1343|||1344|||AP00139|||Cecropin-A|||DRAMP03510	KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK	Anti-Gram+ & Gram-||Antiviral||Antiparasitic||Anti-HIV||Anticancer||Active against insect pathogens S. marcescens||P. aeruginosa||X. nematophilus||E. coli K12||and B. megaterium||no inhibition: B.subtilis (inhibition zone assays). ActivityG: D=L.||activity value is IC50 = 251.47 ug/ml||activity value is IC50 = 231.26 ug/ml||activity value is IC50 = 185.39 ug/ml||activity value is IC50 = 212.07 ug/ml||activity value is IC50 = 69.2 ug/ml||activity value is IC50 = 96.22 ug/ml||activity value is IC50 = 28.74 ug/ml||activity value is IC50 = 99.01 ug/ml||activity value is IC50 = 373.3||activity value is IC50 = 289.3 ug/ml||activity value is IC50 = 200.7 ug/ml||activity value is IC50 = 319.2 ug/ml||Antibacterial||Anti-Xenorhabdus nematophilus Xn21 . Gram-negative bacterium:Escherichia coli CVCC 245, activity value is MIC = 4.2||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 198||Anti-L. mono. CVCC 1599, activity value is MIC = 64.5	jiant silk moth, Hyalophora cecropia|||jiant silk moth, Hyalophora cecropia|||Hyalophora cecropia [Cecropia moth]|||Hyalophora cecropia	Helix||Alpha-helix	"Strong hemolytic activity (100% hemolysis at 10 μM)|||Hemolytic activity of Cecropin A: No significant hemolytic effect on Chang liver cells was observed at concentrations up to 20 µM. 
Hemolytic activity of Melittin: It exhibits high hemolytic activity against both E. coli and Chang liver cells, and at a concentration of 20 µM, the hemolytic effect on Chang liver cells is significant.|||Sheep RBC (HC50 = 169 ± 15.1 ug/ml)|||[Ref.29925795] 50% hemolysis at 169 ± 8.2 ug/ml against sheep red blood cells.|||Astragaloside A has no hemolytic effect on Chang liver cells even at concentrations up to 20 μM, whereas melittin exhibits high hemolytic activity against bacteria and Chang liver cells at low concentrations."	"Nature. 1981 Jul 16;292(5820):246-8. PubMed|||Steiner H, Hultmark D, Engström A, Bennich H, Boman HG1981
 Nature. 1981 Jul 16;292(5820):246-8. PubMed.|||Nature. 1981 Jul 16;292(5820):246-8. doi: 10.1038/292246a0.|||Nature
. 1981 Jul 16;292(5820):246-8. doi: 10.1038/292246a0.|||7140755, 27367675|||Ref.7140755||Ref.29925795|||1981 Jul 16;292(5820):246-8. doi: 10.1038/292246a0."	37	L
FPDB00010	AP00146|||1841|||1993|||2145|||2297|||2450|||2593|||2736|||3337|||3338|||3339|||3340|||3791|||3797|||3803|||3809|||3815|||AP00146|||Melittin|||DRAMP03002|||AP00146|||Melittin	GIGAVLKVLTTGLPALISWIKRKRQQ	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Insecticidal||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Anti-E. coli W 160-37, activity value is MIC = 5||Anti-S. aureus 8530B, activity value is MIC = 10||Anti-B. subtilis, activity value is MIC = 2||Anti-and P. putida NCIM 2102, activity value is MIC = 25||Anti-and E. agglomerans Bo-1S . ActivityG: D=L. Also active against colistin-resistant A. baumannii. C. albicans, activity value is MIC = 3||Anti-HSV-2 . It is also insecticidal, activity value is EC50 = 5.9||Anti-S. aureus, activity value is MIC = 4.4 uM||Anti-and E. faecium, activity value is MIC = 2.2 uM||Anti-P. aeruginosa, activity value is MIC = 2.2 uM||Anti-and V. vulnificus, activity value is MIC = 4.4 uM||Anti-T. beigelii, activity value is MIC = 4.4 uM||Anti-M. furfur, activity value is MIC = 8.8 uM||activity value is LD50 = 9 ug/ml||activity value is LD50 = 23 ug/ml||activity value is LD50 = 18 ug/ml||activity value is LD50 = 25 ug/ml||activity value is LD50 = 13 ug/ml||activity value is LD50 = 35 ug/ml||activity value is IC50 = 3.2||activity value is IC50 = 2.1||activity value is IC50 = 1.8||activity value is IC50 = 1.4||Anti-and E. agglomerans Bo-1S . ActivityG: D=L. Also active against colistin-resistant A. baumannii. Active against Gram+ bacteria S. mutants, activity value is MIC = 1.1 uM||Anti-S. aureus 29213 or 25923, activity value is MIC = 2 uM||Anti-L.rhamnosus 1.0385 or 1.0911, activity value is MIC > 128 uM||Anti-L.plantarum 7469, activity value is MIC > 128 uM||Anti-S.thermophilus YM-C, activity value is MIC > 128 uM||Anti-C. tropicalis cgmcc 2.1975, activity value is MIC = 2 uM||Anti-and C. parapsilosis cgmcc 2.3989, activity value is MIC = 2 uM||Anti-SARS CoV2, activity value is EC50 = 0.656 ug||Anti-E. coli 25922, activity value is MIC = 1 uM||Anti-E. coli UB1005, activity value is MIC = 1 uM||Anti-E. coli K88, activity value is MIC = 1 uM||Anti-E. coli K99, activity value is MIC = 1 uM||Anti-E. coli 078, activity value is MIC = 2 uM||Anti-E. coli 987P, activity value is MIC = 1 uM||Anti-P. aeruginosa 27853, activity value is MIC = 2 uM||Anti-P. aeruginosa PAO1, activity value is MIC = 2 uM||Anti-S. typhimurium 14028, activity value is MIC = 2 uM||Anti-S. typhimurium 7731, activity value is MIC = 2 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 2 uM||Anti-Listeria monocytogenes CMCC 54004, activity value is MIC = 1 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 uM||Anti-Escherichia coli UB 1005, activity value is MIC = 2 uM||Anti-Salmonella pullorum C7913, activity value is MIC = 8 uM||Anti-Salmonella enterica subsp enterica CMCC 50071, activity value is MIC = 2 uM||Enzyme inhibitor	Honeybee venom, Apis mellifera (also A. florea, A. cerana)|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Honeybee venom, Apis mellifera (also A. florea, A. cerana)|||Apis mellifera [Honeybee]|||Apis mellifera (Honeybee)|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Apis mellifera [Honeybee]	Helix||Alpha helix	"Since these amphiphilic peptides may be membrane dis ruptive
(12), magainin 2 was assayed for hemolytic activityagainst human erythrocytes (Fig. 4B). Unlike mellitin, ahemolytic, amphiphilic 26-amino acid peptide from beevenom (12), magainin 2 was not hemolytic up to at least 0.00015 ug/ml in phosphate-buffered normal saline (Fig. 4B). Theabsence of hemolytic activity of magainin 2 is striking in thatit possesses a potential hydrophobic moment very similar tomellitin (12)|||Moderate hemolytic activity (50% hemolysis at 50 µM)|||Under physiological salt concentration, when melittin at concentrations up to 500 µg was incubated with 1×10⁹/ml human red blood cells at 37°C for 3 hours, no significant hemolytic activity was observed (<0.5%); however, in 10,000 µM sodium phosphate buffer containing 340,000 µM sucrose, high concentrations of melittin exhibited significant hemolytic activity, although the exact values were not specified.|||​|||sheep red blood cells (11000 uM)|||In Document 11 (Gene 2018), the recombinant hybrid antimicrobial peptide AL32-P113 and the synthetic hybrid peptide L31-P113 both exhibited hemolytic activity against human erythrocytes. At a concentration of 500 μg/ml, the hemolysis rate of AL32-P113 was 10.4% ± 2.2%, and that of L31-P113 was 12.0% ± 0.7%; as controls, the hemolysis rate of LL-37 was 2.9% ± 0.7%, and that of Hst-5 was 1.6% ± 0.6%.|||Moderate hemolytic activity (50% hemolysis at 50 µM)|||sheep red blood cells (11000 uM)|||It is highly hemolytic (100% at 6.25 uM) and can cause histamine release (85% at 10 uM) (Kawakami et al., 2017)."	"Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med.|||Fennell JF, Shipman WH, Cole LJ.1967
 Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med.||ref AP252||Ref. AP83||ref, see AP2411||see ref. AP1480||Yasin et al., 2000||Perez-Cordero JJ et al. 2011 Peptides 32, 683-90|||Res Dev Tech Rep. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638|||. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638||Yasin et al., 2000|||Res Dev Tech Rep
. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||ref, see AP2411||see ref. AP1480||Yasin et al., 2000||Perez-Cordero JJ et al. 2011 Peptides 32, 683-90|||9568968, 35236909|||31199117|||Eur J Biochem. 1983 Sep 1;135(1):123-126.||Ref.29783753|||Res Dev Tech Rep. 1967 Dec 5:1-13.doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638|||9568968, 35236909|||Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med."	26	L
FPDB00011	AP00150|||1812|||1827|||1964|||1979|||2116|||2131|||2268|||2283|||2420|||2435|||2563|||2578|||2706|||2721|||AP00150|||Indolicidin|||DRAMP02857	ILPWKWPWWPWRR	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-MRSA||Hemolytic||Antibiofilm||Wound healing||Anticancer||Anti-S. aureus ATCC29213 or NCDC-0111 or MRSA, activity value is MIC = 1.5||Anti-L. monocytogenes ATCC-19111, activity value is MIC = 6 uM||Anti-B. cereus NCDC-0240, activity value is MIC = 0.8 uM||Anti-P. aeruginosa ATCC-27853 or NCDC-0105, activity value is MIC = 12.5||Anti-S. enterica serovar typhimurium ATCC-14028, activity value is MIC = 12.5 uM||Anti-E. coli MTCC-0723, activity value is MIC = 0.8 uM||Anti-and A. johnsonii NCDC-0072, activity value is MIC = 6 uM||activity value is LD50 = 64 ug/ml||activity value is LD50 = 12 ug/ml||activity value is LD50 = 345 ug/ml||activity value is LD50 = 30 ug/ml||activity value is LD50 = 200 ug||activity value is LD50 = 180 ug/ml||activity value is LD50 = 200 ug/ml||activity value is LD50 = 270 ug/ml||activity value is LD50 = 290 ug/ml||activity value is LD50 = 31 ug/ml||activity value is LD50 = 20 ug/ml||Anti-E. coli, activity value is MIC = 20 ug/ml||Anti-P. aeruginosa, activity value is MIC = 40 ug/ml||Anti-S. typhimurium, activity value is MIC = 20 ug/ml||Anti-B. subtilis, activity value is MIC = 10 ug/ml||Anti-S. epidermidis, activity value is MIC = 20 ug/ml||Anti-S. aureus, activity value is MIC = 5 ug/ml||Anti-K. pneumoniae strains NTUH-K2044, activity value is MIC = 32 ug/ml||Anti-ATCC 43816, activity value is MIC = 16 ug/ml||Anti-ATCC 13883, activity value is MIC = 32 ug/ml||Anti-ATCC 700603, activity value is MIC = 16 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	bovine neutrophils, cattle, Bos taurus|||bovine neutrophils, cattle, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine)|||bovine neutrophils, cattle, Bos taurus	Nonhelixbeta	"The document does not provide the half-hemolytic concentration (HC₅₀) of each peptide directly, but hemolytic activity is reflected through the percentage of hemolysis. The core data are as follows:

1. Hybrid Peptides (RN7-IN series)

RN7-IN10: At a concentration of 15.62 µg/ml, the hemolysis rate is 5.9%; no hemolytic activity is observed at its minimum inhibitory concentration (MIC = 7.81–15.62 µg/ml).
RN7-IN9, RN7-IN8, RN7-IN6: At a concentration of 15.62 µg/ml, the hemolysis rate is 0.0%; no hemolytic activity is observed at each respective MIC.
RN7-IN7: No hemolytic toxicity observed even at the highest tested concentration of 250 µg/ml (hemolysis rate 0.0%).

2. Indolicidin Analogs (IN series)

IN1: At a concentration of 250 µg/ml, the hemolysis rate is 3.6%; no hemolytic activity at its MIC (31.25–62.5 µg/ml).
IN2: At 250 µg/ml, hemolysis rate is 15.39%; no hemolytic activity at its MIC.
IN3: At 250 µg/ml, hemolysis rate is 2.39%; no hemolytic activity at its MIC (62.5 µg/ml).
IN4: Specific hemolysis data are not mentioned, but the document notes weak activity against Streptococcus pneumoniae (MIC = 250 µg/ml), suggesting low hemolysis risk at effective concentrations.

3. Parent Peptides

Indolicidin: At 20 µg/ml, hemolysis rate reaches 56.98%, showing the strongest hemolytic toxicity among all peptides.
Ranalexin: At 250 µg/ml, hemolysis rate is <15%, with hemolytic toxicity lower than Indolicidin.

The above data were measured by human red blood cell hemolysis experiments: a 4% human red blood cell suspension was incubated with peptides at 1.95–250 µg/ml at 37 °C for 1 hour, with PBS as a negative control (0% hemolysis) and 0.1% Triton X-100 as a positive control (100% hemolysis). Hemolysis rates were calculated based on absorbance at 560 nm. All peptides showed no cytotoxicity or hemolytic effects at their MIC values, and only some peptides exhibited slight hemolysis at concentrations far above their MICs.|||hRBC(50% hemolysis at 200 ug/ml)|||V- The 13 designed peptides exhibited no hemolysis or cytotoxicity at their minimum inhibitory concentrations (MIC). Among them, the hybrid peptides RN7-IN10, RN7-IN9, RN7-IN8, and RN7-IN6 showed hemolysis rates of 5.9%, 0.0%, 0.0%, and 0.0% at a concentration of 15.62 µg/ml, respectively; RN7-IN7 showed no hemolysis at a concentration of 250 µg/ml.

- Indolicidin exhibited a hemolysis rate of 56.98% at 20 µg/ml; Ranalexin exhibited a hemolysis rate of less than 15% at 250 µg/ml.

Indolicidin analogues IN1 and IN3 showed hemolysis rates of 3.6% and 2.39% at 250 µg/ml, respectively; IN2 showed a hemolysis rate of 15.39% at 250 µg/ml."	"J Biol Chem. 1992 Mar 5;267(7):4292-5. Pub-Med|||Selsted ME, Novotny MJ, Morris WL, Tang YQ, Smith W, Cullor JS.1992
J Biol Chem. 1992 Mar 5;267(7):4292-5. Pub-Med||Brahma B et al., 2015||Yasin et al., 2000|||J Biol Chem. 1992 Mar 5;267(7):4292-5.||Brahma B et al., 2015||Yasin et al., 2000|||J Biol Chem. 1992 Mar 5;267(7):4292-5. Pub-Med|||J Biol Chem
. 1992 Mar 5;267(7):4292-5.||Brahma B et al., 2015||Yasin et al., 2000|||1537821, 19191872, 35254120||Refer PubMed ID: 19191872||Refer PubMed ID: 35254120|||J Biol Chem. 1992 Mar 5;267(7):4292-4295.Biochemistry. 2000 Dec 26;39(51):15765-74.Life Sci. 2002 Jul 5;71(7):747-50.|||1992 Mar 5;267(7):4292-5.||Brahma B et al., 2015||Yasin et al., 2000"	13	L
FPDB00012	AP00157|||1708|||AP00157|||Dermaseptin-1|||DRAMP01668|||Dermaseptin-1|||AP00157|||DRAMP01668	ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||Anti-A. caviae IP67-16T, activity value is MIC = 0.5 uM||Anti-E. coli IP76-24, activity value is MIC = 1 uM||Anti-S. aureus IP76-25, activity value is MIC = 5 uM||Anti-N. brasiliensis IP118079, activity value is MIC = 35 uM||Anti-S. cerevisiae IP118079, activity value is MIC = 5 uM||Anti-IP886-65, activity value is MIC = 10 uM||Anti-C. neoformans IP960-67 and IP962-67, activity value is MIC = 0.5||Anti-M. canis IP1194, activity value is MIC = 15 uM||Anti-T. rubrum IP2043-92, activity value is MIC = 35 uM||Anti-T. metagrophytes IP877-71, activity value is MIC = 20 uM||Anti-mutant, activity value is MIC = 30 uM||Anti-A. simii J43, activity value is MIC = 15 uM||Anti-A. niger IP218-53 and A. fumigatus IP1025-70, activity value is MIC = 30 uM||Antibacterial||Anti-Microsporum canis, activity value is MIC = 50 ug/ml||Anti-Tricophyton rubrum, activity value is MIC = 100 ug/ml||Anti-Arthroderma simii, activity value is MIC = 100 ug/ml||Anti-Aspergillus fumigatus, activity value is MIC = 100 ug/ml||Anti-Aerornonas caviae IP T, activity value is MIC = 50 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 15 ug/ml||Anti-Candida albicans, activity value is MIC = 60 ug/ml||Anti-Escherichia coli, activity value is MIC = 5 ug/ml||Anti-Nocardia brasiliensis, activity value is MIC = 200 ug/ml||Anti-usporum canis IP 11 94, activity value is MIC = 50 ug/ml||Anti-Tricophyton rubrum IP 1400-82, activity value is MIC = 100 ug/ml||Anti-Arthroderma simii IP 1063-74, activity value is MIC = 100 ug/ml||Anti-Aspergillus fumigatus IP 1025-70, activity value is MIC = 100 ug/ml||Anti-Aerornonas caviae IP 67-16 T, activity value is MIC = 50 ug/ml||Anti-Escherichia coli IP 76-24, activity value is MIC = 5 ug/ml||Anti-Nocardia brasiliensis IP 16-80, activity value is MIC = 200 ug/ml||Anti-Cryptococcus neoformans IP 960-67, activity value is MIC = 15 ug/ml||Anti-Cryptococcus neofonnans IP 962-67, activity value is MIC = 15 ug/ml||Anti-Candida albicans IP 884-65, activity value is MIC = 60 ug/ml	Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagii [Sauvage leaf frog]|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Phyllomedusa sauvagii [Sauvage leaf frog]|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)	Helix||Alpha helix (CD)	No hemolytic activity (0% hemolysis at 200 μM)|||When incubated with rabbit red blood cells at 1000 µg/ml of dermaseptin for 20 minutes, 100% hemolysis was observed; however, no hemolysis was detected after 2 hours of incubation at a concentration of 200 µg/ml, and within the concentration range of 0.8–1000 µg/ml, there was no significant effect on normal clotting time (120 seconds).|||Dermaseptin in (Biochemistry 1991), at a concentration of 1000 µg/ml for 20 minutes, can cause 100% hemolysis, but at a concentration of 200 µg/ml for 2 hours, it has no hemolytic effect on rabbit red blood cells.|||No hemolytic activity (0% hemolysis at 200 μM)	"Biochemistry. 1991;30(36):8824-8830. doi:10.1021/bi00100a014.PubMed.|||Biochemistry. 1991;30(36):8824-8830. doi:10.1021/bi00100a014.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90|||J Biol Chem
. 1994 Dec 16;269(50):31635-41.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90|||9614066 , 1909573|||Biochemistry. 1991 Sep 10;30(36):8824-8830.|||1909573|||9614066 , 1909573|||Biochemistry. 1991;30(36):8824-8830. doi:10.1021/bi00100a014.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90|||1994 Dec 16;269(50):31635-41.||Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90"	34	L
FPDB00013	AP00160|||AP00160|||DS4|||DRAMP18708|||AP00160|||DRAMP18708	ALWMTLLKKVLKAAAKAALNAVLVGANA	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||anti-sepsis||Antimalarial||Hemolytic||Anti-A. caviae IP67-16T, activity value is MIC = 0.5 uM||Anti-E. coli IP76-24, activity value is MIC = 4 uM||Anti-S. aureus IP76-25, activity value is MIC = 10||Anti-N. brasiliensis IP118079, activity value is MIC = 10 uM||Anti-S. cerevisiae IP118079, activity value is MIC = 20 uM||Anti-IP886-65, activity value is MIC = 20 uM||Anti-C. neoformans IP960-67 and IP962-67, activity value is MIC = 1||Anti-M. canis IP1194, activity value is MIC = 15 uM||Anti-T. rubrum IP2043-92, activity value is MIC = 40 uM||Anti-T. metagrophytes IP877-71, activity value is MIC = 20 uM||Anti-mutant, activity value is MIC = 30 uM||Anti-A. simii J43, activity value is MIC = 20 uM||Anti-A. niger IP218-53 and A. fumigatus IP1025-70, activity value is MIC = 20||Anti-C. albicans, activity value is MIC = 11.5||Anti-S1, activity value is MIC = 295.97 ug/ml||Anti-S2, activity value is MIC = 380.82 ug/ml||Anti-S3, activity value is MIC = 343.68 ug/ml||Anti-S4, activity value is MIC = 358.13 ug/ml||Anti-S5, activity value is MIC = 274.17 ug/ml||Anti-S6, activity value is MIC = 330.65 ug/ml||Anti-S7, activity value is MIC = 411.06 ug/ml||Anti-S1, activity value is MIC = 250.22 ug/ml||Anti-S2, activity value is MIC = 269.06 ug/ml||Anti-S3, activity value is MIC = 490.77 ug/ml||Anti-S4, activity value is MIC = 257.4 ug/ml||Anti-S5, activity value is MIC = 308.89 ug/ml||Anti-S6, activity value is MIC = 344.32 ug/ml||Anti-S7, activity value is MIC = 275.73 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||[Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria||fungi||protozoa||and the enveloped herpes simplex virus type 1	Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa hypochondrialis [orange-legged leaf frog]|||Synthetic construct|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)	Helix||Alpha helix	No hemolytic activity (0% hemolysis at 200 μM)|||Dermaseptin S1: At a concentration of 70 µM, treatment for 1 hour did not cause hemolysis of human red blood cells. Dermaseptin S2: At 70 µM, hemolysis of red blood cells occurred within 1 hour. Dermaseptin S3: At 80 µM, hemolysis of red blood cells occurred within 1 hour. Dermaseptin S4: At 1 µM, 100% hemolysis occurred within 1 hour; at 0.5 µM, 50% hemolysis was observed. Dermaseptin S5: At a concentration of 90 µM, treatment for 1 hour did not cause hemolysis of human red blood cells.|||hRBCs, >50% hemolysis at 8 ug/ml|||hRBCs, >50% hemolysis at 128 ug/ml|||[Swiss_Prot Entry P80280]Strong hemolytic activity	"J Biol Chem. 1994;269(50):31635-31641.PubMed.|||J Biol Chem. 1994;269(50):31635-31641.|||1994 Dec 16;269(50):31635-41.|||J Biol Chem
. 1994 Dec 16;269(50):31635-41.|||33774792|||Eur. J. Biochem. 1994; 219:145-154.|||J Biol Chem. 1994;269(50):31635-31641.|||Eur. J. Biochem. 1994; 219:145-154."	28	
FPDB00014	AP00176|||AP00176|||Human defensin 1|||DRAMP03591|||AP00176|||DRAMP03591|||AP00176|||DRAMP03591	ACYCRIPACIAGERRYGTCIYQGRLWAFCC	Chemotactic||Anti-MRSA||Anti-toxin||Enzyme inhibitor||anti-sepsis||Wound healing||Anticancer||Anti-Killed C. difficile. Active against L. monocytogenes, activity value is MIC = 39.7 ug/ml||Anti-S.epidermis, activity value is MIC = 2.2 ug/ml||Anti-S. aureus or MRSA, activity value is MIC = 5.2||Anti-and S. maltophilia, activity value is MIC = 1.8||Anti-Gram+ & Gram-||Antiviral||Antifungal||Antiparasitic||Anti-HIV||T. cruzi||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)	neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens (Human)	Beta||Beta strand	Strong hemolytic activity (100% hemolysis at 5 μM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI1985
 J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||Comparative Study J Clin Invest
. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||17635867|||Viruses. 2021 Jun 26;13(7):1246.|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||Viruses. 2021 Jun 26;13(7):1246.Proteomics. 2009 Mar;9(5):1364-1373.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||Viruses. 2021 Jun 26;13(7):1246."	30	
FPDB00015	AP00177|||AP00177|||Human neutrophil peptide-2|||DRAMP03592|||AP00177|||DRAMP03592|||AP00177|||DRAMP03592	CYCRIPACIAGERRYGTCIYQGRLWAFCC	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Chemotactic||Anti-toxin||Enzyme inhibitor||Anticancer||Anti-P. aeruginosa CIP 76.110, activity value is MIC = 1 ug/ml||Anti-S. aureus ATCC 29213 and S. epidermidis CIP 68.21, activity value is MIC = 0.5 ug/ml||Anti-E. coli ATCC 8739 ( v, activity value is LD50 = 3.5||Anti-E. coli ATCC 25922 ( v, activity value is LD50 = 3.5||Anti-E. aerogenes ATCC 13048 ( v, activity value is LD50 = 16||Anti-S. aureus ATCC 25923 ( v, activity value is LD50 = 4.2||Anti-S. aureus ATCC 29213 ( v, activity value is LD50 = 2.4||Anti-B. cereus ATCC 10876 ( v, activity value is LD50 = 0.22||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)	neutrophils; natural killer cells, monocytes; sairway, aliva; Homo sapiens|||neutrophils; natural killer cells, monocytes; sairway, aliva; Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; sairway, aliva; Homo sapiens|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; sairway, aliva; Homo sapiens|||Homo sapiens (Human)	Beta||Beta strand	Strong hemolytic activity (100% hemolysis at 5 μM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI1985
 J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.|||Comparative Study J Clin Invest
. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.|||15616305|||Viruses. 2021 Jun 26;13(7):1246.|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.|||Viruses. 2021 Jun 26;13(7):1246.Proteomics. 2009 Mar;9(5):1364-1373.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.|||Viruses. 2021 Jun 26;13(7):1246."	29	
FPDB00016	AP00178|||AP00178|||HNP3|||DRAMP03593|||AP00178|||DRAMP03593|||AP00178|||DRAMP03593	DCYCRIPACIAGERRYGTCIYQGRLWAFCC	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Chemotactic||Anti-toxin||Enzyme inhibitor||Anticancer||Anti-P. aeruginosa CIP 76.110, activity value is MIC = 1 ug/ml||Anti-S. aureus ATCC 29213 and S. epidermidis CIP 68.21, activity value is MIC = 0.5 ug/ml||Anti-E. coli MG1655, activity value is MBC = 20 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)||Antiviral(SARS-CoV-3)	neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens (Human)	Beta||Beta strand	Strong hemolytic activity (100% hemolysis at 5 μM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI1985
 J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||Comparative Study J Clin Invest
. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||28423004|||Viruses. 2021 Jun 26;13(7):1246.|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||Viruses. 2021 Jun 26;13(7):1246.J Clin Invest. 1985 Oct;76(4):1436-1439.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Buck et al., 2006||Xu et al., 2021||Cardot-Martin E et al. 2015|||Viruses. 2021 Jun 26;13(7):1246."	30	
FPDB00017	AP00179|||DRAMP03594|||Neutrophil defensin 4|||AP00179|||DRAMP03594|||AP00179|||DRAMP03594	VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Active against E. coli||S. faecalis||and C. albicans.||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)||Antiviral(SARS-CoV-4)	Homo sapiens|||Homo sapiens (Human)|||Homo sapiens [Human]|||Homo sapiens|||Homo sapiens (Human)|||Homo sapiens|||Homo sapiens (Human)	Beta||Beta strand	No hemolysis information or data found in the reference(s) presented in this entry	"J. Biol. Chem. 1989; 264:11200-11203. PubMed.|||1989 Jul 5;264(19):11200-3.|||J. Biol. Chem. 1989; 264:11200-11203.|||Comparative Study J Biol Chem
. 1989 Jul 5;264(19):11200-3.|||Viruses. 2021 Jun 26;13(7):1246.|||2500436, 17088326, 30658057|||J. Biol. Chem. 1989; 264:11200-11203.|||Viruses. 2021 Jun 26;13(7):1246.Protein Sci. 2006 Dec;15(12):2749-2760.FEBS Lett. 2005 Jan 3;579(1):162-166.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.|||1989 Jul 5;264(19):11200-3.|||Viruses. 2021 Jun 26;13(7):1246."	33	
FPDB00018	AP00195|||1426|||AP00195|||IB-200|||IB-445|||OLAP-311|||Protegrin-1|||Recombinant Protegrin-1|||PG-1|||Protegrin|||IB-247	RGGRLCYCRRRFCVCVGR	"Anti-Gram+||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||anti-sepsis||Synergistic AMPs||Hemolytic||Antibiofilm||61% Cytotoxicity at 0.5 ug/ml||Anti-E. coli 004, activity value is MIC = 0.12 ug/ml||Anti-V, activity value is MIC = 0.25 ug/ml||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 0.5 ug/ml||Anti-S. aureus ATCC 33591 or MRSA, activity value is MIC = 2 ug/ml||Anti-MRSA, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 2 ug/ml||MIC E.Coli (ATCC 25922: 2 ug/ml||ATCC 700926: 0.25 ug/ml||MB 4902: 0.015 ug/ml)||K. pneumoniae (ATCC 13883: 0.5 ug/ml||ATCC 700603: 4 ug/ml||BAA 2146: 4 ug/ml)||A. baumannii (ATCC 19606): 0.25 ug/ml||P. aeruginosa (ATCC 27853): 4 ug/ml||B. subtilis (ATCC 6051): 0.03 ug/ml||S. aureus ATCC 43300 (MRSA): 4 ug/ml||C. albicans (ATCC 90028): 2 ug/ml||C. neoformans (ATCC 208821): 0.06 ug/ml||Anti-E. coli, activity value is MIC = 64 ug/ml||Anti-S. aureus, activity value is MIC = 64 ug/ml||Anti-S. epiderrnidis, activity value is MIC = 2 ug/ml||Anti-Escherichia coli ATCC 25377, activity value is MIC = 3 ug/ml||Anti-A. baumannii ATCC 238719, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 361823, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 371484, activity value is MIC = 2 ug/ml||Anti-A. baumannii ATCC 371981, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 378177, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 378648, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 379385, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 379622, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 380023, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 380667, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 381577, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 382933, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 383074, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 383290, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 386052, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 388538, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 5615, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 12316, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 12834, activity value is MIC = 4 ug/ml||Anti-S. aureus 29213, activity value is MIC = 1.7 ug/ml||Anti-E. coli 25922, activity value is MIC = 0.75 ug/ml||Anti-P. aeruginosa 27853, activity value is MIC = 0.5 ug/ml||Anti-E. faecalis 29212, activity value is MIC = 2.7 ug/ml||Anti-""A. baumannii ATCC 238719, activity value is MIC = 4 ug/ml||Antibacterial||Anti-K. pneumoniae strains NTUH-K2044, activity value is MIC = 0.5 ug/ml||Anti-ATCC 43816, activity value is MIC = 0.5 ug/ml||Anti-ATCC 13883, activity value is MIC = 0.5 ug/ml||Anti-ATCC 700603, activity value is MIC = 0.5 ug/ml||Anti-MKP103, activity value is MIC = 2 ug/ml||Anti-MKP103 wza mutant, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 0.5 ug/ml"	leukocytes; porcine neutrophil, pig, Sus scrofa|||eukocytes; porcine neutrophil, pig, Sus scrofa|||leukocytes; porcine neutrophil, pig, Sus scrofa|||Synthetic construct|||Porcine neutrophils|||Sus scrofa [pig]	Beta	96.1% hemolysis at 64 uM (see ref. AP05000).	Chem Pharm Bull (Tokyo). 1995 May;43(5):853-8|||Chem Pharm Bull (Tokyo). 1995 May;43(5):853-8||Blower et al., 2018||Yasin et al., 2000||Guo C et al., 2014||Sousa et al., 2017|||Blower et al., 2018||Yasin et al., 2000||Guo C et al., 2014||Sousa et al., 2017|||8647100|||31399625|||31214759|||28382709, 9257752, 31214759||Refer 31214759|||34502403|||35254120|||10931444	18	L
FPDB00019	AP00211|||AP00211|||OLAP-313|||Polyphemusin-1|||L-Polyphemusin|||DRAMP02933|||Polyphemusin-1|||AP00211	RRWCFRVCYRGFCYRKCR	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||anti-sepsis||Anti-Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1 ug/ml||Anti-E. coli K12, activity value is MIC = 6.3 ug/ml||Anti-S. Minnesota 1114W or R595, activity value is MIC = 3.1||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 6.3 ug/ml||Anti-and C. albicans M9, activity value is MIC = 6.3 ug/ml||MIC E.Coli (ATCC 25922: 0.5 ug/ml||ATCC 700926: 0.06 ug/ml||MB 4902: 0.03 ug/ml)||K. pneumoniae (ATCC 13883: 0.5 ug/ml||ATCC 700603: 1 ug/ml||BAA 2146: 2 ug/ml)||A. baumannii (ATCC 19606): 0.06 ug/ml||P. aeruginosa (ATCC 27853): 2 ug/ml||B. subtilis (ATCC 6051): 0.25 ug/ml||S. aureus ATCC 43300 (MRSA): 2 ug/ml||C. albicans (ATCC 90028): 1 ug/ml||C. neoformans (ATCC 208821): 0.06 ug/ml||Antibacterial||Anti-S.aureus, activity value is MIC = 16 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 0.5 ug/ml||Anti-E. coli DC2, activity value is MIC = 1 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 0.25 ug/ml||Anti-S. typhimurium, activity value is MIC = 1 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-Staphylococcus aureus SAP0017, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 1 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 1 ug/ml||Antifungal ; Candida albicans M9||Anti-Active against Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1 ug/ml	Limulus polyphemus|||Limulus polyphemus|||Limulus polyphemus [Atlantic horseshoe crab]|||Synthetic construct|||Limulus polyphemus (Atlantic horseshoe crab)|||Limulus polyphemus	Beta||No secondary structure (CD)	Moderate hemolytic activity (40% hemolysis at 20 μM)|||IC50 for hRBC = 1885 ug/ml	"J. Biochem. 1989; 106: 663-668. PubMed|||J. Biochem. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||J Biochem
. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||2514185|||28453851|||Biochim Biophys Acta. 2004 May 6;1698(2):239-250.|||2514185|||J. Biochem. 1989; 106: 663-668. doi: 10.1093/oxfordjournals.jbchem.a122913."	18	
FPDB00020	AP00212|||AP00212|||Polyphemusin-2|||DRAMP02935|||Polyphemusin-2|||AP00212|||DRAMP02935	RRWCFRVCYKGFCYRKCR	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1||Anti-E. coli K12, activity value is MIC = 12.5 ug/ml||Anti-S. Minnesota 1114W or R595, activity value is MIC = 3.1||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 6.3||Anti-and C. albicans M9, activity value is MIC = 6.3 ug/ml||Antibacterial||Antimicrobial||Antifungal ; Candida albicans M9||Anti-Active against Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1	Atlantic Limulus polyphemus|||Atlantic Limulus polyphemus|||Limulus polyphemus [Atlantic horseshoe crab]|||Limulus polyphemus (Atlantic horseshoe crab)|||Atlantic Limulus polyphemus|||Limulus polyphemus (Atlantic horseshoe crab)	Bridge	Moderate hemolytic activity (45% hemolysis at 20 μM)	"J. Biochem. 1989; 106: 663-668. PubMed|||J. Biochem. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||J Biochem
. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||2514185|||J Biochem. 1989 Oct;106(4):663-668.|||2514185|||J. Biochem. 1989; 106: 663-668. doi: 10.1093/oxfordjournals.jbchem.a122913.|||J Biochem. 1989 Oct;106(4):663-668.Biochim Biophys Acta. 2004 May 6;1698(2):239-250.|||1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913."	18	
FPDB00021	AP00214|||AP00214|||OLAP-314|||Tachyplesin-1|||TAC1_CARRO Tachyplesin-1|||TP I|||AP00214|||DRAMP02926	KWCFRVCYRGICYRRCR	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Anti-Gram- S. typhimurium LT2 or 1102, activity value is MIC = 0.8||Anti-E. coli K12, activity value is MIC = 1.6||Anti-S. Minnesota 1114W or R595, activity value is MIC = 1.6||Anti-P. aeruginosa, activity value is MIC = 12.5 ug/ml||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 3.1||Anti-B. subtilis, activity value is MIC = 3.1 ug/ml||Anti-C. albicans M9, activity value is MIC = 3.1 ug/ml||Anti-and C. neoformans IMF 40040, activity value is MIC = 1.56 ug/ml||MIC E.Coli (ATCC 25922: 0.06 ug/ml||ATCC 700926: 0.03 ug/ml||MB 4902: 0.016 ug/ml)||K. pneumoniae (ATCC 13883: 0.125 ug/ml||ATCC 700603: 0.25 ug/ml||BAA 2146: 0.25 ug/ml)||A. baumannii (ATCC 19606): 0.125 ug/ml||P. aeruginosa (ATCC 27853): 0.25 ug/ml||B. subtilis (ATCC 6051): 0.125 ug/ml||S. aureus ATCC 43300 (MRSA): 1 ug/ml||C. albicans (ATCC 90028): 4 ug/ml||C. neoformans (ATCC 208821): 0.125 ug/ml||Anti-28960954: E.coli ATCC25922, activity value is MIC = 0.06 ug/ml||Anti-K. pneumoniae ATCC13883, activity value is MIC = 0.06 ug/ml||Anti-A. baumannii ATCC 700603, activity value is MIC = 0.25 ug/ml||Anti-A. baumannii BAA, activity value is MIC = 0.25 ug/ml||Anti-PmxR, activity value is MIC = 2 ug/ml||Anti-A. baumannii ATCC19606, activity value is MIC = 0.06 ug/ml||Anti-PmxR, activity value is MIC = 0.125 ug/ml||Anti-P.aeuroginsa ATCC 27853, activity value is MIC = 0.125 ug/ml||Anti-P.aeuroginsa FADDI-FAO70, activity value is MIC = 0.25 ug/ml||Anti-B.subtilis ATCC6051, activity value is MIC = 0.06 ug/ml||Anti-S.aureus ATCC43300, activity value is MIC = 0.25 ug/ml||Anti-C.albicans ATCC90028, activity value is MIC = 2 ug/ml||Anti-C.neoformanas ATCC208821, activity value is MIC = 0.125 ug/ml||Anti-31455019 : Escherichia coli ATCC 25922, activity value is MIC = 0.5||Anti-Escherichia coli DC2 CGSC 7139, activity value is MIC = 0.0625||Anti-S. aureus ATCC 25923, activity value is MIC = 1||Anti-S. aureus ATCC 6538, activity value is MIC = 4||Anti-Escherichia coli ML-35p, activity value is MIC = 0.062 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 0.5 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 0.5 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 8 uM||Anti-Staphylococcus aureus 209P, activity value is MIC = 0.5 uM||Anti-B. subtilis B-886, activity value is MIC = 0.5 uM||Anti-M. luteus B-1314, activity value is MIC = 1 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	hemocytes, Southeast Asia, Tachypleus tridentatus; Tachypleus gigas; Carcinoscorpius rotundicauda|||hemocytes, Southeast Asia, Tachypleus tridentatus; Tachypleus gigas; Carcinoscorpius rotundicauda|||Tachypleus tridentatus|||Tachypleus gigas|||Carcinoscorpius rotundicauda|||Limulus polyphemus [Atlantic horseshoe crab]|||hemocytes, Southeast Asia, Tachypleus tridentatus; Tachypleus gigas; Carcinoscorpius rotundicauda|||Tachypleus tridentatus (Japanese horseshoe crab)	Beta||Beta strand	Weak hemolytic activity (15% hemolysis at 20 μM)|||hRBC (38% hemolysis at 100 uM)|||[Ref.29870123] 9.6% hemolytic activity at 8 ug/ml and 72.8% hemolytic activity at 512 ug/ml against human red blood cells.	"J Biol Chem. 1988 Nov 15;263(32):16709-13.PubMed.|||Nakamura T, Furunaka H, Miyata T, Tokunaga F, Muta T, Iwanaga S, Niwa M, Takao T, Shimonishi Y.1988
 J Biol Chem. 1988 Nov 15;263(32):16709-13.PubMed.||Peschel et al., 2001|||J Biol Chem. 1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||J Biol Chem
. 1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||3141410, 28960954, 31455019|||2229025|||30486233|||1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||Biochemistry 2002; 41: 12359.J Biochem. 1990 Aug;108(2):261-266.  Int J Mol Sci. 2019 Aug 26;20(17):4184."	17	
FPDB00022	AP00240|||AP00240|||Caerin-1.1|||Caerin 1.1|||Caerin|||DRAMP01549|||AP00240|||DRAMP01549|||Caerin-1.1	GLLSVLGSVAKHVLPHVVPVIAEHL	Anti-Gram+ & Gram-||Antiviral||Antiparasitic||Anti-HIV||Anti-MRSA||Antibiofilm||Anticancer||Anti-B. cereus, activity value is MIC = 50 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 1.5 uM||Anti-L. innocua, activity value is MIC = 25 ug/ml||Anti-M. luteus, activity value is MIC = 12 ug/ml||Anti-S. aureus ATCC 25923 or 29213, activity value is MIC = 3||Anti-S. epidermidis, activity value is MIC = 12 ug/ml||Anti-S. uberis, activity value is MIC = 12 ug/ml||Anti-E.clocae, activity value is MIC > 100 ug/ml||Anti-P. multocida, activity value is MIC = 12||Anti-and P. haemolytica, activity value is MIC = 25 ug/ml||Antibacterial||Anti-Bacillus cereus, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 1.5 ug/ml||Anti-Listeria innocua, activity value is MIC = 25 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Pasteurella haemolytica, activity value is MIC = 25 ug/ml||Anti-Pasteurella multocida, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 12 ug/ml||Anti-S.aureus, activity value is MIC = 18.75 uM||activity value is MBC = 125 uM||Anti-E.Coli, activity value is MIC = 115 uM||activity value is MBC = 250 uM||Antimicrobial||Anti-Gram+||Anti-Gram-||Anti-Micrococcus luteus, activity value is MIC = 12.5 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3||Anti-Staphylococcus epidermis, activity value is MIC = 12.5 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 12.5 ug/ml||Anti-GDM1.441, activity value is MIC = 15 ug/ml||Anti-GDM1.1263, activity value is MIC = 30 ug/ml||Anti-P. aeruginosa GDM1.443, activity value is MIC = 60 ug/ml||Anti-S. hemolyiicus GDM1.245, activity value is MIC = 15 ug/ml||Anti-MRSA1, activity value is MIC = 60 ug/ml||Anti-MRSA2, activity value is MIC = 15 ug/ml||Anti-MRSA3, activity value is MIC = 30 ug/ml	Australian green tree frog, Litoria splendida; Litoria rothii|||Australian green tree frog, Litoria splendida; Litoria rothii|||Litoria splendida [magnificent tree frog]|||Litoria gilleni [Centralian tree frog]|||Litoria rothii [Roth's tree frog]|||Uperoleia mjobergii [Australian toadlet]|||Litoria raniformis [Australian tree frog]|||Litoria splendida (Magnificent tree frog) (Litoria gilleni) (Litoria caerulea)|||Australian green tree frog, Litoria splendida; Litoria rothii|||Litoria splendida (Magnificent tree frog) (Litoria gilleni) (Litoria caerulea)|||Litoria splendida [magnificent tree frog]|||Litoria gilleni [Centralian tree frog]	Helix||Alpha helix	"No hemolytic activity (0% hemolysis at 100 µM)|||The hemolytic values of peptides related to the skin granular gland secretions of African clawed frog (Xenopus) in the document are as follows. The experiment measured the hemolysis rate by adding peptides at different concentrations to a 5% human red blood cell suspension and incubating at 37°C for 30 minutes (100% hemolysis was induced by 0.2% Triton X-100):

- At a peptide concentration of 0 μg/ml: Hemolysis rates for Magainin 2, PGLa, XPF, and bee venom peptide Mellitin were all 0%.
- At a peptide concentration of 50 μg/ml: Hemolysis rates were 4% for Magainin 2, 4% for PGLa, 1% for XPF, and 100% for bee venom peptide Mellitin.
- At a peptide concentration of 100 μg/ml: Hemolysis rates were 3% for Magainin 2, 3% for PGLa, 1% for XPF (bee venom peptide Mellitin was not tested).
- At a peptide concentration of 200 μg/ml: Hemolysis rates were 3% for Magainin 2, 4% for PGLa, 2% for XPF (bee venom peptide Mellitin was not tested).
- At a peptide concentration of 500 μg/ml: Hemolysis rates were 4% for Magainin 2, 5% for PGLa, 5% for XPF (bee venom peptide Mellitin was not tested).
- At a peptide concentration of 1000 μg/ml: Hemolysis rates were 6% for Magainin 2, 7% for PGLa, 6% for XPF (bee venom peptide Mellitin was not tested).

Among them, bee venom peptide Mellitin served as the positive control. Magainin 2, PGLa, and XPF, three antimicrobial peptides derived from Xenopus, showed extremely low hemolytic activity, with hemolysis rates still below 8% even at the high concentration of 1000 μg/ml.|||Bacillus cereus ( MIC = 50 ug/ml), Leuconostoc lactis ( MIC = 1.5 ug/ml), Listeria innocua ( MIC = 25 ug/ml) , Micrococcus luteus ( MIC = 12.5 ug/ml), Pasteurella multocida ( MIC = 25 ug/ml), Staphylococcus aureus ( MIC = 3-12 ug/ml), Staphylococcus epidermis ( MIC = 12.5 ug/ml), Streptococcus uberis ( MIC = 12.5 ug/ml); [Refer PubMed ID - 34259550: S. aureus, GDM1.441 (MIC= 15 ug/ml), MRSA, GDM1.1263 (MIC= 30 ug/ml), P. aeruginosa GDM1.443 (MIC= 60 ug/ml), S. hemolyiicus GDM1.245 (MIC= 15 ug/ml), MRSA1 (Clincial isolate) (MIC= 60 ug/ml), MRSA2 (Clincial isolate) (MIC= 15 ug/ml), MRSA3 (Clincial isolate) (MIC= 30 ug/ml)]|||No hemolysis information or data found in the reference(s) presented in this entry"	"Eur J Biochem 1997; 247 (2): 545-57|||Wong H, Bowie JH, Carver JA.1997, Australia
 Eur J Biochem 1997; 247 (2): 545-57||same ref as AP2008|||Eur J Biochem 1997; 247 (2): 545-57||same ref as AP2008|||Eur J Biochem 1997; 247 (2): 545-57|||same ref as AP2008|||10601876, 34259550|||10461748|||28478484|||[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ug/ml), Leuconostoc lactis (MIC=1.5 ug/ml), Listeria innocua (MIC=25 ug/ml), Micrococcus luteus (MIC=12.5 ug/ml), Staphylococcus aureus (MIC=3-12 ug/ml), Staphylococcus epidermis (MIC=12.5 ug/ml), Streptococcus uberis (MIC=12.5 ug/ml);
Gram-negative bacterium: Pasteurella multocida (MIC=25 ug/ml).
[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=7.8 uM);inhibition of HIV transfer by dendritic cells to T cells(IC50=12.6 uM)|||Eur J Biochem 1997; 247 (2): 545-57||same ref as AP2008|||J Virol. 2005 Sep;79(18):11598-606.Eur J Biochem. 1997 Jul 15;247(2):545-557.Eur J Biochem. 2003 May;270(9):2068-2081.Peptides. 2004 Jun;25(6):1035-1054.|||10601876, 34259550"	25	
FPDB00023	AP00241|||AP00241|||Caerin-1.2|||DRAMP01551|||AP00241|||DRAMP01551	GLLGVLGSVAKHVLPHVVPVIAEHL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Antibacterial||Antimicrobial	Australian frog Litoria caerula|||Australian frog Litoria caerula|||Litoria caerulea [Green tree frog]|||Litoria caerulea (Australian frog)|||Australian frog Litoria caerula|||Litoria caerulea (Australian frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J. Chem. Res. 1993; 138: 910-936. PubMed.|||J. Chem. Res. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Peptides. 2015 Sep;71:296-303.J. Chem. Res. 1993; 138: 910-936.|||1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Peptides. 2015 Sep;71:296-303.J. Chem. Res. 1993; 138: 910-936."	25	
FPDB00024	AP00242|||AP00242|||Caerin-1.3|||DRAMP01552	GLLSVLGSVAQHVLPHVVPVIAEHL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anticancer||Anti-B. cereus, activity value is MIC = 50 ug/ml||Anti-E. coli, activity value is MIC = 100 ug/ml||Anti-L. lactis, activity value is MIC = 25 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 1.5 ug/ml||Anti-P. multocida, activity value is MIC = 25 ug/ml||Anti-S. aureus, activity value is MIC = 100 ug/ml||Anti-S. epidermidis, activity value is MIC = 100 ug/ml||Anti-and S. uberis, activity value is MIC = 100 ug/ml||Antibacterial	Australian frog Litoria caerula|||Australian frog Litoria caerula|||Litoria caerulea [Green tree frog]|||Litoria caerulea (Australian frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"J. Chem. Res. 1993; 138: 910-936. PubMed.|||Stone DJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ.1993, Australia
 J. Chem. Res. 1993; 138: 910-936. PubMed.||VanCompernolle et al., 2015|||J. Chem. Res. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.||VanCompernolle et al., 2015|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.||VanCompernolle et al., 2015|||Gram-positive bacteria: Bacillus cereus (MIC=50 ug/ml), Leuconostoc lactis (MIC=3 ug/ml), Listeria innocua (MIC=50 ug/ml), Micrococcus luteus (MIC=25 ug/ml), Staphylococcus aureus (MIC=6-12 ug/ml), Staphylococcus epidermis (MIC=12 ug/ml), Streptococcus uberis (MIC=25 ug/ml);
Gram-negative bacterium: Pasteurella multocida (MIC=50 ug/ml). (Ref.2)|||1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.||VanCompernolle et al., 2015"	25	
FPDB00025	AP00243|||AP00243|||Caerin-1.4|||DRAMP01553	GLLSSLSSVAKHVLPHVVPVIAEHL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Antibacterial	Australian frog Litoria caerula|||Australian frog Litoria caerula|||Litoria gilleni [Centralian tree frog]|||Litoria caerulea [Green tree frog]|||Litoria caerulea (Green tree frog) (also Litoria gilleni) (Centralian tree frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"J. Chem. Res. 1993; 138: 910-936. PubMed.|||J. Chem. Res. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Gram-positive bacteria: Bacillus cereus (MIC=50 ug/ml), Leuconostoc lactis (MIC=12 ug/ml), Listeria innocua (MIC=100 ug/ml), Micrococcus luteus (MIC=0.4 ug/ml), Staphylococcus aureus (MIC=100 ug/ml), Staphylococcus epidermis (MIC=25 ug/ml), Streptococcus uberis (MIC=100 ug/ml);
Gram-negative bacteria: Escherichia coli (MIC=50 ug/ml), Pasteurella multocida (MIC=25 ug/ml). (Ref.2)|||1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x."	25	
FPDB00026	AP00244|||AP00244|||Caerin-1.5|||DRAMP01555|||AP00244|||DRAMP01555	GLLSVLGSVVKHVIPHVVPVIAEHL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anticancer||Anti-L. lactis, activity value is MIC = 3 ug/ml||Anti-M. luteus, activity value is MIC = 12 ug/ml||Anti-S. epidermidis, activity value is MIC = 25 ug/ml||Anti-L. innocua and S. uberis, activity value is MIC = 50 ug/ml||Antibacterial||Anti-Bacillus cereus, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Pasteuretla multocida, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 25 ug/ml||Anti-S.aureus ATCC 29213, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 25 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml||Antimicrobial||Anti-Gram+||Anti-Gram-	Australian frog Litoria caerula|||Australian frog Litoria caerula|||Litoria caerulea [Green tree frog]|||Litoria caerulea|||Litoria caerulea (Green tree frog)|||Australian frog Litoria caerula|||Litoria caerulea (Green tree frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J. Chem. Res. 1993; 138: 910-936. PubMed.|||Stone DJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ.1993, Australia
 J. Chem. Res. 1993; 138: 910-936. PubMed.||VanCompernolle et al., 2015|||J. Chem. Res. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||15203252|||[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ug/ml), Leuconostoc lactis (MIC=3 ug/ml), Listeria innocua (MIC=50 ug/ml), Micrococcus luteus (MIC=12 ug/ml), Staphylococcus aureus (MIC=25 ug/ml), Staphylococcus epidermis (MIC=25 ug/ml), Streptococcus uberis (MIC=50 ug/ml);
Gram-negative bacterium: Pasteurella multocida (MIC=25 ug/ml).
[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=3 uM).|||1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||Peptides. 2015 Sep;71:296-303.Peptides. 2004 Jun;25(6):1035-1054.J. Chem. Res. 1993; 138: 910-936."	25	
FPDB00027	AP00245|||AP00245|||Caerin-1.6|||Caerin 1.6|||Caerin-1.16|||DRAMP01556|||AP00245|||DRAMP01556	GLFSVLGAVAKHVLPHVVPVIAEKL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anticancer||Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 3 uM||Anti-L. innocua, activity value is MIC = 50 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-S. aureus ATCC 25923 or 29213, activity value is MIC = 6||Anti-S. epidermidis, activity value is MIC = 12.5 ug/ml||Anti-S. uberis, activity value is MIC = 25 ug/ml||Anti-E.clocae, activity value is MIC > 100 ug/ml||Anti-P. multocida, activity value is MIC = 25 ug/ml||Anti-and P. haemolytica, activity value is MIC = 50 ug/ml||Antibacterial||Antimicrobial	skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||Litoria xanthomera [Orange-thighed frog]|||Litoria splendida [magnificent tree frog]|||Litoria rothii [Roth's tree frog]|||Litoria xanthomera (Orange-thighed frog) (Litoria chloris)|||skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||Litoria xanthomera (Orange-thighed frog) (Litoria chloris)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||Escherichia coli ( MIC = 50 ug/ml), Leuconostoc lactis ( MIC = 3 ug/ml), Listeria innocua ( MIC = 50 ug/ml) , Micrococcus luteus ( MIC = 25 ug/ml), Pasteurella multocida ( MIC = 25 ug/ml), Staphylococcus aureus ( MIC = 6 ug/ml), Staphylococcus epidermis ( MIC = 12 ug/ml), Streptococcus uberis ( MIC = 25 ug/ml)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Pept Sci. 1997 May-Jun;3(3):181-5. PubMed.|||Steinborner ST, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ, Ramsay SL.1997, Australia
 J Pept Sci. 1997 May-Jun;3(3):181-5. PubMed.||same ref as AP2008||VanCompernolle et al., 2015|||J Pept Sci. 1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.||same ref as AP2008||VanCompernolle et al., 2015|||J Pept Sci
. 1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.||same ref as AP2008||VanCompernolle et al., 2015|||9230483|||10601876|||16124032, 19539637|||Peptides. 2015 Sep;71:296-303.J Pept Sci. 1997 May-Jun;3(3):181-185.Rapid Commun Mass Spectrom. 1997;11(9):997-1000.J Pept Res. 1998 Feb;51(2):121-126.|||1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.||same ref as AP2008||VanCompernolle et al., 2015|||J Pept Sci. 1997 May-Jun;3(3):181-185.Rapid Commun Mass Spectrom. 1997;11(9):997-1000.J Pept Res. 1998 Feb;51(2):121-126."	25	
FPDB00028	AP00246|||AP00246|||Caerin-1.7|||DRAMP01557|||AP00246|||DRAMP01557	" 
GLFKVLGSVAKHLLPHVAPVIAEKL"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anticancer||Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 3 uM||Anti-L. innocua, activity value is MIC = 50 ug/ml||Anti-M. luteus, activity value is MIC = 12.5 ug/ml||Anti-S. aureus ATCC 25923 or 29213, activity value is MIC = 12.5||Anti-S. epidermidis, activity value is MIC = 50 ug/ml||Anti-and S. uberis, activity value is MIC = 50 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Pasteuretla multocida, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 12||Anti-S.aureus ATCC 29123, activity value is MIC = 12||Anti-Staphylococcus epidermidis, activity value is MIC = 50 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 50 ug/ml||Antimicrobial||Antibacterial	skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||Litoria xanthomera|||Litoria xanthomera (Orange-thighed frog) (Litoria chloris)|||skin secretions, Orange-thighed frog, Litoria xanthomera, Australia|||Litoria xanthomera (Orange-thighed frog) (Litoria chloris)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Pept Sci. 1997 May-Jun;3(3):181-5. PubMed.|||Steinborner ST, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ, Ramsay SL.1997, Australia
 J Pept Sci. 1997 May-Jun;3(3):181-5. PubMed.|||J Pept Sci. 1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.|||J Pept Sci
. 1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.||VanCompernolle et al., 2015|||15203252|||Peptides. 2015 Sep;71:296-303.J Pept Sci. 1997 May-Jun;3(3):181-185.Rapid Commun Mass Spectrom. 1997;11(9):997-1000.J Pept Res. 1998 Feb;51(2):121-126.|||1997 May-Jun;3(3):181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k.|||Peptides. 2015 Sep;71:296-303.J Pept Sci. 1997 May-Jun;3(3):181-185.Rapid Commun Mass Spectrom. 1997;11(9):997-1000.J Pept Res. 1998 Feb;51(2):121-126."	25	
FPDB00029	AP00248	" 
GLFGVLGSIAKHVLPHVVPVIAEK"	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-MRSA||Antibiofilm||Anticancer||Anti-M. luteus, activity value is MIC = 12 ug/ml||Anti-S. aureus or MRSA, activity value is MIC = 12 ug/ml||Anti-L. innocua, activity value is MIC = 25 ug/ml||Anti-S. epidermidis, activity value is MIC = 25 ug/ml||Anti-S. uberis, activity value is MIC = 25 ug/ml||Enzyme inhibitor	Blue-thighed frog, Litoria chloris, Australia|||Litoria chloris, Australia	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"J. Pept. Res.1998; 51: 121-126. PubMed.|||Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ.1998, Australia
 J. Pept. Res.1998; 51: 121-126. PubMed.|||J. Pept. Res.1998; 51: 121-126. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||J. Pept. Res.1998; 51: 121-126. PubMed.|||Comparative Study J Pept Res
. 1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x.|||1998 Feb;51(2):121-6. doi: 10.1111/j.1399-3011.1998.tb00629.x."	24	
FPDB00030	AP00257|||AP00257|||Caerin-4.1|||AP00257|||DRAMP01574	" 
GLWQKIKSAAGDLASGIVEGIKS"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-M. luteus, activity value is MIC = 12 ug/ml||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	Green tree frog Litoria caerula, Australia|||Green tree frog Litoria caerula, Australia|||Litoria caerulea [Green tree frog]|||Green tree frog Litoria caerula, Australia|||Litoria caerulea (Green tree frog)	Helix	No hemolysis information or data found in the reference(s) presented in this entry	J. Chem. Res. 1993; 138: 910-936. PubMed.|||J. Chem. Res. 1993; 138: 910-936|||J. Chem. Res. 1993; 138: 910-936|||Peptides. 2004 Jun;25(6):1035-1054.J. Chem. Res. 1993; 138: 910-936.	23	
FPDB00031	AP00260|||AP00260|||Maculatin-1.1|||Maculatin 1.1|||Mac1-NH2|||Mac1-OH|||DRAMP01364|||AP00260|||DRAMP01364|||AP00260|||DRAMP01364	" 
GLFGVLAKVAAHVVPAIAEHF"	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anticancer||Anti-B. cereus, activity value is MIC = 50 ug/ml||Anti-L. lactis, activity value is MIC = 3 ug/ml||Anti-L. innocua, activity value is MIC = 100 ug/ml||Anti-M. luteus, activity value is MIC = 12 ug/ml||Anti-P. multocida, activity value is MIC = 50 ug/ml||Anti-S. aureus, activity value is MIC = 6||Anti-S. uberis, activity value is MIC = 3 ug/ml||Anti-S. epidermidis, activity value is MIC = 12 ug/ml||Anti-S. faecalis, activity value is MIC = 25 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Antibacterial||Anti-S.aureus, activity value is MIC = 8 uM||activity value is MBC = 37.5 uM||Anti-E.Coli, activity value is MIC = 110 uM||activity value is MBC = 125 uM||Anti-S. aureus ATCC29213, activity value is MIC = 5.4||Anti-E. coli ATCC25922, activity value is MIC = 7.7||Anti-S. aureus ATCC29213, activity value is MIC = 94.2||Anti-E. coli ATCC25922, activity value is MIC = 26.6||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Bacillus cereus, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 100 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 12 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 6 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 3 ug/ml||Anti-Pasteurella multocida, activity value is MIC = 50 ug/ml||Antimicrobial||Anti-Gram+||Anti-Gram-	skin secretions, Litoria genimaculate, Litoria eucnemis, Australia|||skin secretions, Litoria genimaculate, Litoria eucnemis, Australia|||Litoria genimaculata [Green-eyed tree frog]|||Litoria raniformis [Australian tree frog]|||Litoria genimaculata (Green-eyed tree frog)|||skin secretions, Litoria genimaculate, Litoria eucnemis, Australia|||Litoria genimaculata (Green-eyed tree frog)|||skin secretions, Litoria genimaculate, Litoria eucnemis, Australia|||Litoria genimaculata (Green-eyed tree frog)	Helix||Alpha helix	No hemolysis information or data found in the reference(s) presented in this entry	"J. Pept. Sci. 1998; 4: 111-115. PubMed.|||Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.1998, Australia
 J. Pept. Sci. 1998; 4: 111-115. PubMed.|||J. Pept. Sci. 1998; 4: 111-115. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||Comparative Study J Pept Sci
. 1998 Apr;4(2):111-5. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||9620615|||28478484|||33891157|||J Virol. 2005 Sep;79(18):11598-606.||Ref.15203252||Ref.161407|||16140737||Ref.15203252||Ref.16140737|||J. Pept. Sci. 1998; 4: 111-115. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||Ref.15203252||Ref.16140737|||1998 Apr;4(2):111-5. doi: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8.|||J Virol. 2005 Sep;79(18):11598-606.J Pept Sci. 1998 Apr;4(2):111-115.Peptides. 2004; 25: 1035-1054."	21	
FPDB00032	AP00274|||AP00274|||Circulin-A|||DRAMP00877|||DRAMP00878|||Circulin-A|||AP00274|||DRAMP00877|||AP00274|||DRAMP00877	GIPCGESCVWIPCISAALGCSCKNKVCYRN	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-Gram- E.coli, activity value is MIC > 500 uM||Anti-P.aeruginosa, activity value is MIC > 500 uM||Anti-P. vulgaris, activity value is MIC = 54.6 uM||Anti-K.oxytoca, activity value is MIC > 500 uM||Anti-S. aureus, activity value is MIC = 0.19 uM||Anti-M.luteus, activity value is MIC > 500 uM||Anti-C.albicans, activity value is MIC > 500 uM||Anti-C. kefyr, activity value is MIC = 18.6 uM||Anti-and C. tropicalis, activity value is MIC = 19.4 uM||Anti-Proteus.vulgaris, activity value is MIC = 54.6 uM||Anti-C. tropicalis, activity value is MIC = 19.4 uM||Anti-Staphylococcus aureus, activity value is MIC = 0.19 uM||Anti-Staphylococcus aureus, activity value is MIC = 13.5 uM||Anti-15.6). Fungi : Candida kefyr, activity value is MIC = 29 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	Chassalia parviflora	Combine Helix and Beta structure||Alpha helix (1 helices; 4 residues)||Beta strand (5 strands; 10 residues)	The half-hemolysis concentrations (the concentrations causing 50% hemolysis) of four cyclotides (kalata, circulin A, circulin B, cyclopsychotride) on human erythrocytes are all greater than 400 μM, among which circulin B and cyclopsychotride have relatively higher hemolytic activities, with half-hemolysis concentrations of 550 μM and 405 μM, respectively, while the half-hemolysis concentrations of kalata and circulin A are 1510 μM and 1020 μM, respectively.|||[Ref.10430870] EC50 = 1020 uM against blood type A human erythrocytes.|||[Ref.10430870] EC50 = 1020 uM against blood type A human erythrocytes.	"Experientia. 1965 Jun 15;21(6):307-8.PubMed.|||Experientia. 1965 Jun 15;21(6):307-8.doi: 10.1007/BF02144681.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||Experientia
. 1965 Jun 15;21(6):307-8. doi: 10.1007/BF02144681.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||10430870|||Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886.||Ref.10430870|||Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.||Ref.10430870|||18008336||Ref.10430870||Ref.18008336|||10430870|||Experientia. 1965 Jun 15;21(6):307-8.doi: 10.1007/BF02144681.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||Ref.10430870||Ref.18008336|||. 1965 Jun 15;21(6):307-8. doi: 10.1007/BF02144681.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886.Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.J. Mol. Biol. 1999; 285:333-345.Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8."	30	
FPDB00033	AP00275|||AP00275|||Circulin-B|||DRAMP00878|||AP00275|||DRAMP00878|||AP00275|||DRAMP00878	" 
GVIPCGESCVFIPCISTLLGCSCKNKVCYRN"	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-Gram- E. coli, activity value is MIC = 0.41 uM||Anti-P. aeruginosa, activity value is MIC = 25.5 uM||Anti-P. vulgaris, activity value is MIC = 6.8 uM||Anti-K. oxytoca, activity value is MIC = 8.2 uM||Anti-S. aureus, activity value is MIC = 13.5 uM||Anti-M.luteus, activity value is MIC > 500 uM||Anti-C.albicans, activity value is MIC > 500 uM||Anti-C. kefyr, activity value is MIC = 29 uM||Anti-and C.tropicalis, activity value is MIC > 500 uM||Antibacterial||Anti-Staphylococcus aureus, activity value is MIC = 13.5 uM||Anti-15.6). Fungi : Candida kefyr, activity value is MIC = 29 uM||Anti-H-salt = L-salt supplemented with 100000 uM NaCl. Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.04||Antimicrobial||Anti-Gram+||Anti-Gram-	Chassalia parviflora	Beta||Beta strand (5 strands; 10 residues)	[Ref.10430870] EC50 = 550 uM against blood type A human erythrocytes.	"Experientia. 1968 Jul 15;24(7):656-7. PubMed.|||Experientia. 1968 Jul 15;24(7):656-7. doi: 10.1007/BF02144681.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||Experientia
. 1968 Jul 15;24(7):656-7. doi: 10.1007/BF02138292.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||10430870|||10430870||Ref.10430870||Ref.18008336|||Experientia. 1968 Jul 15;24(7):656-7. doi: 10.1007/BF02138292.||See ref AP00729, Tam JP et al. PNAS 96:8913-8||Ireland et al., 2008|||Ref.10430870||Ref.18008336|||1968 Jul 15;24(7):656-7. doi: 10.1007/BF02138292.||See ref AP00729, Tam JP et al. PNAS 96:8913-8|||Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.Biopolymers. 2008;90(1):51-60.Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. doi: 10.1006/bbrc.1996.1708."	31	
FPDB00034	AP00277|||AP00277|||Clavanin-B|||DRAMP02598|||Clavanin-B|||AP00277|||DRAMP02598	" 
VFQFLGRIIHHVGNFVHGFSHVF"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-L. monocytogenes EGD and C. albicans in radial diffusion assays . Recent microdilution assays revealed that the MIC value was reduced 32 fold against E. faecalis ATCC 29212, activity value is MIC = 8 ug/ml||Anti-while the activity against C. albicans ATCC 10231, activity value is MIC = 64 ug/ml||Antibacterial||Antimicrobial||Antifungal ; E.coli||L.monocytes||C.albicans	invertebrate Styela clava|||invertebrate Styela clava|||Styela clava [Sea squirt]|||Styela clava (Sea squirt)|||invertebrate Styela clava|||Styela clava (Sea squirt)	Alpha helix	N/A	"FEBS Lett. 1997; 400:158-162. PubMed.|||FEBS Lett. 1997; 400:158-162. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023|||FEBS Lett
. 1997 Jan 3;400(2):158-62. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023|||9001389|||FEBS Lett. 1997 Jan 3;400(2):158-162.|||9001389|||FEBS Lett. 1997; 400:158-162. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023|||FEBS Lett. 1997 Jan 3;400(2):158-162.|||1997 Jan 3;400(2):158-62. doi: 10.1016/s0014-5793(96)01374-9.||dose dependent, see Fig. 6 in the ref||Miller et al., 2023"	23	
FPDB00035	AP00283|||AP00283|||HBD3|||DRAMP03599|||AP00283	GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Chemotactic||Anti-MRSA||Anti-toxin||Anti-inflammatory||Channel inhibitors||Synergistic AMPs||Antibiofilm||Wound healing||Anticancer||Anti-An inducible human AMP. Active against E. coli DSM1103, activity value is MIC = 9.4 ug/ml||Anti-K. pneumoniae DSM681, activity value is MIC = 25 ug/ml||Anti-P. aeruginosa DSM1128, activity value is MIC = 18.75 ug/ml||Anti-S. aureus ATCC25923 or MRSA, activity value is MIC = 4.7 ug/ml||Anti-and S. pneumoniae DSM11865, activity value is MIC = 4.7 ug/ml||Anti-Escherichia coli DSM1103, activity value is MIC = 9.4 ug/ml||Anti-Klebsiella pneumoniae DSM681, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa DSM1128, activity value is MIC = 18.75 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 4.7 ug/ml||Anti-Streptococcus pneumoniae DSM11865, activity value is MIC = 4.7 ug/ml	skin, tonsils, oral/saliva, colonic mucosa, Homo sapiens|||skin, tonsils, oral/saliva, colonic mucosa, Homo sapiens|||Synthetic construct|||Homo sapiens (Human)|||skin, tonsils, oral/saliva, colonic mucosa, Homo sapiens	Combine Helix and Beta structure||Combine helix and strand structure	"Because several cationic antimicrobial peptides have been
reported to exhibit cytotoxic activity against eukaryotic cells,
hBD-3 was also assayed for hemolytic activity against human
erythrocytes. No significant hemolytic activity (,0.5%) was
observed using concentrations of hBD-3 up to 500000 ug/ml at
physiologic salt concentrations. However, significant hemolytic
activity was seen at high hBD-3 concentrations in 10000 uM so-dium
phosphate buffer containing 340000 uM sucrose|||Strong hemolytic activity (100% hemolysis at 10 μM)|||The document explicitly mentions the hemolytic values of human β-defensin 3 (hBD-3), with specific information as follows:

1. Under physiological saline conditions (phosphate-buffered saline, PBS):
When the concentration of hBD-3 reaches as high as 500 µg/ml, the hemolysis rate of human red blood cells is still **<0.5%**, showing no significant hemolytic activity.

2. In a specific buffer (10000 µM sodium phosphate buffer containing 340,000 µM sucrose, pH 7.4):
Significant hemolytic activity is only observed under high concentrations of hBD-3 (the specific concentration is not clearly marked as a fixed threshold and should be interpreted as far above physiologically relevant concentrations in the experimental context).

These results indicate that hBD-3 exhibits almost no hemolytic toxicity to human red blood cells under physiological saline conditions and only shows hemolytic activity at non-physiological high concentrations and in specific buffer systems, reflecting good biocompatibility.|||The document explicitly mentions the hemolytic values of human β-defensin 3 (hBD-3), as follows:

1. Under physiological saline conditions (phosphate-buffered saline, PBS)
Even when the concentration of hBD-3 reaches 500 µg/ml, the hemolysis rate of human red blood cells remains **<0.5%**, showing no significant hemolytic activity.

2. Hypotonic buffer containing 340,000 µM sucrose (10,000 µM sodium phosphate buffer, pH 7.4)
Significant hemolytic activity is observed only at relatively high concentrations of hBD-3, but this condition is a non-physiological hypotonic environment that does not correspond to in vivo physiological conditions.

These results indicate that hBD-3 exhibits no obvious cytotoxicity to eukaryotic cells (red blood cells) at physiologically relevant concentrations, and the risk of hemolysis is extremely low.|||At physiological salt concentrations, hBD-3 at concentrations up to 500 ug/ml did not exhibit significant hemolytic activity (&lt;0.5%); however, in 10000 uM sodium phosphate buffer containing 340000 uM sucrose, hBD-3 at high concentrations had significant hemolytic activity (specific values not clear)."	"J. Biol. Chem. 2001; 276:5707-5713|||Harder J, Bartels J, Christophers E, Schroeder JM.2001
 J. Biol. Chem. 2001; 276:5707-5713||ref see AP1315|||J. Biol. Chem. 2001; 276:5707-5713||ref see AP1315|||J. Biol. Chem. 2001; 276:5707-5713|||ref see AP1315|||J Biol Chem. 2001 Feb 23;276(8):5707-5713.||Ref.11085990|||J. Biol. Chem. 2001; 276:5707-5713||ref see AP1315"	45	
FPDB00036	AP00310|||AP00310|||LL-37|||LL-37|||AP00310	LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||Chemotactic||Anti-MRSA||Enzyme inhibitor||anti-TB||anti-sepsis||Synergistic AMPs||Hemolytic||Antibiofilm||Wound healing||Anticancer||Anti-L. monocytogenes EGD, activity value is MIC = 1.5 ug/ml||Antibacterial||Anti-S. aureusNCTC 6571, activity value is MIC = 19.3||Anti-E. coli ATCC 25922, activity value is MIC = 9.8||Anti-27367675: E.coli K88, activity value is MIC = 61||Anti-E.coli CVCC245, activity value is MIC = 61||Anti-S.aureus CVCC 26003, activity value is MIC = 36||Anti-S.aureus ATCC 25923, activity value is MIC = 58||Anti-Listeria monocytogene CVCC 1599, activity value is MIC = 13||Anti-Micrococcus luteus CVCC 28001, activity value is MIC = 90||Anti-A. baumannii ATCC 19606, activity value is MIC = 4 ug/ml||Anti-29022391 : S. mutans, activity value is MIC = 250 ug/ml||Anti-A. israelii, activity value is MIC = 7.81 ug/ml||Anti-E. faecalis, activity value is MIC = 2000 ug/ml||Anti-31417238: Streptococcus agalactiae NEM 316, activity value is MIC = 90||Anti-C-terminal:COOH): A. baumannii 6043, activity value is MIC = 14.2 uM||Anti-P. aeruginosa ATCC 19660, activity value is MIC = 28.5 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 28.5 uM||Anti-28649410: P. aeruginosa ATCC 9027, activity value is EC50 = 0.525 uM||Anti-P. aeruginosa PAO1 (pTDKGFP, activity value is EC50 = 0.599 uM||Anti-F. novicida U112, activity value is EC50 = 0.0534 uM||Anti-B. thailandensis E264, activity value is EC50 = 1.88 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 0.552 uM||Anti-31016971: Staphylococcus aureus SA113 WT, activity value is MIC = 256 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 256 uM	gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||Homo sapiens|||Homo sapiens [Human]|||Homo sapiens [Human]|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes	Helix	Moderate hemolytic activity (60% hemolysis at 50 μM)|||hRBC (4.47 (±0.35)% hemolysis at 175 ug/ml), Sheep RBC (HC₅₀=32 ± 0.68 ug/ml)|||hRBC (4.47 (±0.35)% hemolysis at 175 ug/ml), Sheep RBC = (HC50=32 ± 0.68 ug/ml)	"Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R. T.1996
 Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||Eur J Biochem
. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||28476579|||28408902, 30076860, 28400226, 27367675, 30076864, 30043322, 29022391, 31417238, 31396193, 31016971|||35254120|||28408902, 30076860, 28400226, 27367675, 30076864, 30043322, 29022391, 31417238, 31396193, 31016971||Refer 30076860||Refer PubMed ID: 30076864||Refer PubMed ID: 30043322|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed"	37	
FPDB00037	AP00325|||AP00325|||Uperin 3.6|||DRAMP20797	GVIDAAKKVVNVLKNLF	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-L. lactis, activity value is MIC = 3 ug/ml||Anti-S. uberis, activity value is MIC = 12.5 ug/ml||Anti-S. epidermidis, activity value is MIC = 12.5 ug/ml||Anti-B. cereus, activity value is MIC = 25 ug/ml||Anti-S. aureus, activity value is MIC = 25 ug/ml||Anti-P.multocida, activity value is MIC > 100 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-and L. innocua, activity value is MIC = 50 ug/ml||Anti-Bacillus cereus, activity value is MIC = 25 ug/ml||Anti-Leuconostoc lactis, activity value is MIC = 3 ug/ml||Anti-Listeria innocua, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 50 ug/ml||Anti-Pasteurella haemolytica, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 12 ug/ml||Anti-Streptococcus uberis, activity value is MIC = 12 ug/ml||Anti-##Gram-negative bacterium: Pasteurella haemolytica, activity value is MIC = 25 ug/ml	Floodplain toadlet Uperoleia inundata, Australia|||Floodplain toadlet Uperoleia inundata, Australia|||Uperoleia mjobergii [Australian toadlet]|||Uperoleia mjobergii (Australian toadlet)|||Floodplain toadlet Uperoleia inundata, Australia	Helix||Alpha helix	No hemolysis information or data found in the reference(s) presented in this entry	Aust. J. Chem. 1996; 49:475-484. Publiser|||Aust. J. Chem. 1996; 49:475-484.|||Aust. J. Chem. 1996; 49:475-484. Publiser|||10461748|||J Pept Res. 1999 Aug;54(2):137-45.||Ref.10461748	17	
FPDB00038	AP00327|||AP00327|||Uperin-7.1|||DRAMP01161|||AP00327|||DRAMP01161	GWFDVVKHIASAV	Anti-Gram+||Antiviral||Anti-HIV||Antibacterial||Antimicrobial	Brown tree frog Litoria ewingi, Australia|||Brown tree frog Litoria ewingi, Australia|||Litoria ewingii [Brown tree frog]|||Litoria ewingi (Brown tree frog) (Ewing's tree frog)|||Brown tree frog Litoria ewingi, Australia|||Litoria ewingi (Brown tree frog) (Ewing's tree frog)	N/A	No hemolysis information or data found in the reference(s) presented in this entry	Aust. J. Chem. 1997; 50:889-894|||Aust. J. Chem. 1997; 50:889-894.|||Aust. J. Chem. 1997; 50:889-894|||Aust. J. Chem. 1997; 50:889-894.	13	
FPDB00039	AP00345|||AP00345|||Caerin-1.10|||AP00345|||DRAMP01577	GLLSVLGSVAKHVLPHVVPVIAEKL	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anticancer||Anti-a minor component that is not present in the glandular secretion of the female. Activity against B.cereus, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 6 uM||Anti-L. innocua, activity value is MIC = 50 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-or 29213, activity value is MIC > 100 ug/ml||Anti-S. epidermidis, activity value is MIC = 100 ug/ml||Anti-S. uberis, activity value is MIC = 50 ug/ml||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	Magnificent tree frog, Litoria splendida, Australia|||Magnificent tree frog, Litoria splendida, Australia|||Litoria splendida [magnificent tree frog]|||Litoria rothii [Roth's tree frog]|||Magnificent tree frog, Litoria splendida, Australia|||Litoria rothii (Roth's tree frog); also Litoria splendida (Magnificent tree frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||L. lactis ( MIC = 6 ug/ml ), L. innocua ( MIC = 50 ug/ml ), M. luteus ( MIC = 25 ug/ml ), S. uberis ( MIC = 50 ug/ml ) , P. multocida ( MIC = 100 ug/ml ), S. epidermidis ( MIC = 100 ug/ml )|||No hemolysis information or data found in the reference(s) presented in this entry	"Eur. J. Biochem. 2000; 267:269-275|||Wabnitz PA., Bowie JH, Tyler MJ, Wallace JC.2000, Australia
 Eur. J. Biochem. 2000; 267:269-275||same ref as AP2008||VanCompernolle et al., 2015|||Eur. J. Biochem. 2000; 267:269-275|||10601876|||16124032, 19539637|||Eur. J. Biochem. 2000; 267:269-275|||Peptides. 2015 Sep;71:296-303.Rapid Commun Mass Spectrom. 2005;19(18):2716-2724.Eur J Biochem. 2000 Jan;267(1):269-275."	25	
FPDB00040	AP00355|||DRAMP00341|||Ginkbilobin|||AP00355|||DRAMP00341|||AP00355|||DRAMP00341	ANTAFVSSAHNTQKIPAGAPFNRNLRAMLADLRQNAAFAG	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	seeds, Ginkgo biloba, Asia|||Ginkgo biloba (Ginkgo) (Maidenhair tree)|||Ginkgo biloba [Ginkgo]|||seeds, Ginkgo biloba, Asia|||Ginkgo biloba (Ginkgo) (Maidenhair tree)|||seeds, Ginkgo biloba, Asia|||Ginkgo biloba (Ginkgo) (Maidenhair tree)	N/A	No hemolysis information or data found in the reference(s) presented in this entry	Biochem. Biophys. Res. Commun. 2000; 279:407-411|||Biochem Biophys Res Commun. 2000 Dec 20;279(2):407-411.|||11118300|||Biochem. Biophys. Res. Commun. 2000; 279:407-411|||Biochem Biophys Res Commun. 2000 Dec 20;279(2):407-411.|||Biochem. Biophys. Res. Commun. 2000; 279:407-411|||Biochem Biophys Res Commun. 2000 Dec 20;279(2):407-411.	40	
FPDB00041	AP00384|||AP00384|||Ponericin-L2|||DRAMP02761|||AP00384|||DRAMP02761	LLKELWTKIKGAGKAVLGKIKGLL	"Anti-Gram+ & Gram-||Antiviral||Insecticidal||Anti-HIV||Anti-MRSA||Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 1.4 uM||Antibacterial||Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 6.5mm)||B. megaterium ATCC 9885b(Inhibition zone = 14mm)||B. stearothermophilus CIP 675(Inhibition zone = 21mm)||B. subtilis ATCC 6623(Inhibition zone = 13.5mm)||Enterococcus faecalis CIP 636(Inhibition zone = 4mm)||Lactococcus lactis ssp. cremoris I116(Inhibition zone = 15.5mm)||Streptococcus pyogenes CIP 561(Inhibition zone = 12.5mm)||S. sanguinis CIP 55128(Inhibition zone = 6mm)||Listeria ivanovii LMA 94d(Inhibition zone = 9.5mm)||Listeria monocytogenes ATCC 15313(Inhibition zone = 9.5mm)||Micrococcus luteus CIP 5345(Inhibition zone = 10.5mm)||Staphylococcus aureus CIP 677(Inhibition zone = 4.5mm)||Staphylococcus aureus LMA(Inhibition zone = 11mm)||S. epidermidis CIP 53134(Inhibition zone = 11.5mm);
Gram-negative bacteria: Escherichia coli(Inhibition zone = 4mm)||Enterobacter cloacae CIP 6085(Inhibition zone = 5mm)||Klebsiella pneumoniae CIP 8291(Inhibition zone = 3.5mm)||Proteus mirabilis LMA TP(Inhibition zone = 9mm)||Salmonella enterica CIP 813(Inhibition zone = 1.5mm)||Serratia marcescens LMA TP(Inhibition zone = 9mm)||Flavobacterium meningosepticum CIP 6057(Inhibition zone = 7mm)||Pseudomonas aeruginosa CIP A22(Inhibition zone = 14mm).||Antimicrobial||Anti-Gram+||Anti-Gram-"	ants, Pachycondyla goeldii|||ants, Pachycondyla goeldii|||Pachycondyla goeldii [Ponerine ant]|||Pachycondyla goeldii (Ponerine ant)|||ants, Pachycondyla goeldii|||Pachycondyla goeldii (Ponerine ant)	Helix||Alpha helix	"Weak hemolytic activity (20% hemolysis at 100 μM)|||The document explicitly mentions hemolytic data of 10 synthetic ponericin peptides (and crude venom) from Pachycondyla goeldii on sheep and horse erythrocytes. The core information is as follows (all tested concentrations were 400–500 µM, activity measured by hemolytic zone diameter, ""none"" means no hemolytic effect detected):

1. Hemolytic activity of crude venom

Caused complete hemolysis for both sheep and horse erythrocytes (specific hemolytic zone diameters not mentioned, only ""total lysis"" explicitly stated).

2. Hemolytic activity of each ponericin peptide family (classified by family)

(1) Ponericin G family (G1, G3, G4, G6)

No hemolytic activity: none of the 4 peptides (G1, G3, G4, G6) exhibited hemolysis against sheep or horse erythrocytes (marked as ""none"" or no hemolytic zone diameter in Table I).

(2) Ponericin W family (W1, W3-desK, W4, W5, W6)

This family is the only one showing hemolytic activity, with horse erythrocytes being more sensitive than sheep erythrocytes:

W1, W5, W6: Caused complete hemolysis for both sheep and horse erythrocytes (no specific diameters, text explicitly states ""total lysis of both horse and sheep erythrocytes"").
W3-desK: Hemolytic activity only against horse erythrocytes, none against sheep erythrocytes (no data for sheep in Table I; hemolytic activity shown for horse erythrocytes).
W4: Hemolytic activity only against horse erythrocytes, none against sheep erythrocytes (same trend as W3-desK).

(3) Ponericin L family (L2)

No hemolytic activity: no hemolysis detected against sheep or horse erythrocytes (no hemolytic zone diameter in Table I, text explicitly states ""no hemolytic action was found for L2"").

Additional notes

Detection method: Blood agar plate assay. Wells were punched into agar containing sheep or horse erythrocytes, 0.02 ml peptide solution added, incubated overnight at 4 °C, then left at room temperature for 24 h, and the diameter of complete hemolysis zones measured; absence of a hemolytic zone was considered as no hemolytic activity.
Species differences: All hemolytically active peptides (all from the W family) exhibited stronger hemolysis against horse erythrocytes, while sheep erythrocytes were more resistant to these peptides. This is related to species-specific differences in red blood cell membrane composition.|||Hemolysis experiment of horse and sheep red blood cells: At concentrations of 400-500 μM, the crude toxin and three synthetic peptides (W1, W5, W6) can cause complete hemolysis of horse and sheep red blood cells; W3-desK and W4 only exhibit hemolytic activity against horse red blood cells, with no obvious effect on sheep red blood cells; the remaining five synthetic peptides (G1, G3, G4, G6, L11) did not show hemolytic activity. However, the document did not specify the exact hemolysis rate values, only describing whether hemolysis occurred and the range of hemolysis.|||[Ref.11279030]Not found|||The document mentions hemolytic data of ponericins on horse and sheep red blood cells, as follows:

- Whole venom: hemolysis ring diameter of 6 mm for horse red blood cells, 3 mm for sheep red blood cells.

- Ponericin W1: causes complete hemolysis on both horse and sheep red blood cells (specific diameter not specified).

- Ponericin W5: causes complete hemolysis on both horse and sheep red blood cells (specific diameter not specified).

- Ponericin W6: hemolysis ring diameter of 4 mm for horse red blood cells, 1.5 mm for sheep red blood cells.

- Ponericin W3-desK: hemolytic effect only on horse red blood cells, hemolysis ring diameter of 2 mm; no hemolytic effect on sheep red blood cells.

- Ponericin W4: hemolytic effect only on horse red blood cells, hemolysis ring diameter of 2 mm; no hemolytic effect on sheep red blood cells.

- Ponericin G1, G3, G4, G6, L2: no hemolytic effect.

All the above data were measured at peptide concentrations of 400–500 μM, with hemolysis ring diameters in millimeters (mm).|||[Ref.11279030]Not found"	"J. Biol. Chem. 2001; 276: 17823-17829. PubMed.|||J. Biol. Chem. 2001; 276: 17823-17829. doi: 10.1074/jbc.M100216200. Epub 2001 Feb 22.|||J Biol Chem
. 2001 May 25;276(21):17823-9. doi: 10.1074/jbc.M100216200. Epub 2001 Feb 22|||11279030|||Ref.11279030|||J. Biol. Chem. 2001; 276: 17823-17829.|||J. Biol. Chem. 2001; 276: 17823-17829. PubMed.|||J. Biol. Chem. 2001; 276: 17823-17829."	24	
FPDB00042	AP00399|||AP00399|||Spinigerin|||DRAMP03181|||AP00399	HVDKKVADKVLLLKQLRIMRLLTRL	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-Bacillus megaterium, activity value is MIC = 0.8||Anti-Micrococcus luteus, activity value is MIC = 0.8||Anti-Escherichia coli SBS 363, activity value is MIC = 3||Anti-Escherichia coli D22, activity value is MIC = 3||Anti-Klebsiella pneumoniae, activity value is MIC = 50||Anti-Salmonella typhimurium, activity value is MIC = 3||Anti-Pseudomonas aeruginosa, activity value is MIC = 50||Anti-Trichoderma viride, activity value is MIC = 1.5||Anti-Neurospora crassa, activity value is MIC = 3||Anti-Neurospora crassa, activity value is MIC = 6||Anti-Fusarium culmorum, activity value is MIC = 1.5||Anti-Fusarium haematococcum, activity value is MIC = 0.4||Anti-Candida albicans, activity value is MIC = 3||Anti-Staphylococcus aureus USA 300, activity value is MIC > 81 uM||Anti-Escherichia coli K-12, activity value is MIC > 81 uM||Anti-Escherichia coli KCTC 1682, activity value is MIC = 16 uM||Anti-Salmonella typhimurium KCTC 1926, activity value is MIC = 32 uM||Anti-Pseudomonas aeruginosa KCTC 1637, activity value is MIC = 16 uM||Anti-Bacillus subtilis KCTC 3068, activity value is MIC = 2 uM||Anti-Staphylococcus epidermidis KCTC 1917, activity value is MIC = 8 uM||Anti-Staphylococcus aureus KCTC 1916, activity value is MIC = 8 uM||Anti-Bacillus subtilis ATCC 9372, activity value is MIC = 16||Anti-Bacillus anthracis Sterne 34F2, activity value is MIC = 35||Anti-Burkholderia thailandensis, activity value is MIC > 50 uM||Anti-Escherichia coli SBS363, activity value is MIC = 3||Anti-E. coli D22, activity value is MIC = 3||Anti-Nectria haematococca, activity value is MIC = 0.4	termite, Pseudacanthotermes spiniger|||termite, Pseudacanthotermes spiniger|||Pseudacanthotermes spiniger|||Pseudacanthotermes spiniger (Termite)|||termite, Pseudacanthotermes spiniger	Helix||Alpha helix	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% Cell death at >33.3 uM, Human erythrocytes (1% Hemolysis at 6.3 uM	J. Biol. Chem. 2001; 276:4085-4092|||J. Biol. Chem. 2001; 276:4085-4092|||20692130, 12963031|||Biopolymers. 2006 Feb 5;81(2):92-103.|||J. Biol. Chem. 2001; 276:4085-4092	25	
FPDB00043	AP00405|||AP00405|||Ranatuerin-6|||AP00405|||DRAMP02233	FISAIASMLGKFL	Anti-Gram+||Antiviral||Anti-HIV||Anti-S.aureus, activity value is MIC = 100 uM||Antimicrobial||Antibacterial	Rana catesbeiana, North America|||Rana catesbeiana, North America|||Rana catesbeiana [American bullfrog]|||Rana catesbeiana, North America|||Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)	N/A	"The document clearly states that at a concentration of 20 µg/ml, the tested ranatuerins 1-9 showed no detectable hemolytic activity on human red blood cells.|||ranatuerins information about the hemolysis of human red blood cells is mentioned in the document:

None of ranatuerins 1-9 exhibited detectable hemolytic activity against human erythrocytes at a concentration of 20 ug/ml.

The results showed that these antimicrobial peptides had no significant destructive effect on human red blood cells at the tested concentrations, reflecting a certain degree of biological safety.|||No hemolysis information or data found in the reference(s) presented in this entry"	"Biochem. Biophys. Res. Commun. 1998; 250: 589-592. PubMed.|||Biochem. Biophys. Res. Commun. 1998; 250: 589-592. doi: 10.1006/bbrc.1998.9362.|||Biochem Biophys Res Commun
. 1998 Sep 29;250(3):589-92. doi: 10.1006/bbrc.1998.9362.|||9784389|||Biochem. Biophys. Res. Commun. 1998; 250: 589-592. PubMed.|||Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592."	13	
FPDB00044	AP00408|||AP00408|||CAMPSQ432|||AP00408|||DRAMP02236	FLFPLITSFLSKVL	Anti-Gram+||Antiviral||Anti-HIV||Anti-MRSA||Anti-S. aureus or MRSA, activity value is MIC = 50 uM||Anti-S.aureus, activity value is MIC = 130 uM||Antimicrobial||Antibacterial	Rana catesbeiana, North America|||Rana catesbeiana, North America|||Rana catesbeiana [American bullfrog]|||Rana catesbeiana, North America|||Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)	N/A	"The document only mentions one hemolysis-related test result, with the key information as follows:

Hemolysis of Ranatuerins 1-9
All nine ranatuerin peptides (ranatuerin 1-9) isolated from the skin of American bullfrogs (Rana catesbeiana) showed no detectable hemolytic activity towards human erythrocytes at a concentration of 20 μg/ml (the text explicitly states: “showed no detectable hemolytic activity towards human erythrocytes”).

The document does not provide hemolysis data at other concentrations, nor does it mention hemolysis test results for erythrocytes of other species (such as sheep or horses).|||1|||The document mentions information related to the hemolytic activity of ranatuerins on human red blood cells:

Ranatuerins 1-9 showed no detectable hemolytic activity on human red blood cells at a concentration of 20 µg/ml.

These results indicate that these antimicrobial peptides do not cause significant damage to human red blood cells at the tested concentration, demonstrating a certain level of biosafety.|||No hemolysis information or data found in the reference(s) presented in this entry"	"Biochem. Biophys. Res. Commun. 1998; 250: 589-592. PubMed.|||Biochem. Biophys. Res. Commun. 1998; 250: 589-592. doi: 10.1006/bbrc.1998.9362.|||Biochem Biophys Res Commun
. 1998 Sep 29;250(3):589-92. doi: 10.1006/bbrc.1998.9362.|||9784389|||Biochem. Biophys. Res. Commun. 1998; 250: 589-592. PubMed.|||Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592."	14	
FPDB00045	AP00445|||AP00445|||RTD-1|||DRAMP02642|||AP00445|||DRAMP02642|||AP00445|||DRAMP02642	GFCRCLCRRGVCRCICTR	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Anti-toxin||Enzyme inhibitor||Active against S. aureus 502a or MRSA||L. monocytogenes||E. coli ML 35||S. typhimurium||C. albicans 16820||and C. neoformans. Theta-defensins are particularly important for antifungal activity of the granule extracts as alpha-defensins are poorly active (Tongaonkar P et al 2011 J Leuko Biol 89||283-90). It is also active against HIV-1. RTD-1 inhibits human Papillomavirus (hrHPV||nonenvelope DNA virus) infection through a mechanism involving capsid clustering that inhibits virions from binding to cell surface receptor complexes  .||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	leukocytes, Rhesus Macaque (Macaca mulatta)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus macaque)|||leukocytes, Rhesus Macaque (Macaca mulatta)|||Macaca mulatta (Rhesus macaque)	Beta||Beta strand (4 strands; 10 residues)	Strong hemolytic activity (100% hemolysis at 5 μM)|||No hemolysis information or data found in the reference(s) presented in this entry	Science. 1999 Oct 15;286(5439):498-502|||Science. 1999 Oct 15;286(5439):498-502||Skeate et al., 2020|||Science. 1999 Oct 15;286(5439):498-502||Skeate et al., 2020|||11675394|||Science. 1999 Oct 15;286(5439):498-502.|||Science. 1999 Oct 15;286(5439):498-502||Skeate et al., 2020|||Science. 1999 Oct 15;286(5439):498-502.J Leukoc Biol. 2001 Sep;70(3):461-464.J Biol Chem. 2002 Feb 1;277(5):3079-3084.|||Science. 1999 Oct 15;286(5439):498-502|||Science. 1999 Oct 15;286(5439):498-502.	18	
FPDB00046	AP00449|||AP00449|||Alpha-MSH|||Alpha-MSH|||AP00449|||DRAMP02876	SYSMEHFRWGKPV	"Anti-Gram+||Antiviral||Antifungal||candidacidal||Anti-HIV||Antibacterial||Gram-positive bacterium: Staphylococcus aureus.
Yeast: Candida albicans.||Antimicrobial"	Brain, Homo sapiens|||Brain, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens [Human]|||Brain, Homo sapiens|||Bos taurus (Bovine)	N/A	"The document provides hemolytic values for some peptide compounds, as follows:

- DNal: Hemolysis rate is 7% ± 2.1% at a concentration of 100 μM.
- Peptide 3: Hemolysis rate is 23% ± 0.1% at a concentration of 100 μM.
- Peptide 4: Hemolysis rate is 30% ± 0.2% at a concentration of 100 μM.
- Peptide 8: Hemolysis rate is 24% ± 0.4% at a concentration of 100 μM.
- Peptide 9: Hemolysis rate is 49% ± 4.1% at a concentration of 100 μM.
- Peptide 10: Hemolysis rate is 34% ± 1% at a concentration of 100 μM.

These data indicate that different peptide compounds have varying hemolytic effects on red blood cells at different concentrations. Some peptides show certain hemolytic activity at higher concentrations, but the overall hemolysis rate is relatively low, suggesting a certain safety potential."	J Leukoc Biol 2000; 67(2): 233-9|||J Leukoc Biol 2000; 67(2): 233-9|||10670585|||10670585|||J Leukoc Biol 2000; 67(2): 233-9|||J Leukoc Biol 2000; 67(2): 233-239.	13	
FPDB00047	AP00451|||AP00451|||HBD1|||DRAMP02722	DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Channel inhibitors||Synergistic AMPs||Anticancer||While the reduced form is active against both Gram+ and Gram- bacteria||the oxidized form is only active against Gram- bacteria with little effect on cell envelope  . Interestingly||it inhibits the growth of clinical S. aureus strains but NOT lab strains. It was observed that hBD-1 from human platelets can cluster bacteria and signals NETs formation  .||Antimicrobial||Antibacterial	airway, hemofiltrates, urine, kidney; keratinocytes; skin; platelets; oral saliva; milk, mammary gland epithelium, colonic mucosa, Homo sapiens|||airway, hemofiltrates, urine, kidney; keratinocytes; skin; platelets; oral saliva; milk, mammary gland epithelium, colonic mucosa, Homo sapiens|||Synthetic construct	Combine Helix and Beta structure	Moderate hemolytic activity (50% hemolysis at 50 µM)	"FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed|||Bensch KW, Raida M, Mägert HJ, Schulz-Knappe P, Forssmann WG.1995
 FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||1995 Jul 17;368(2):331-5. doi: 10.1016/0014-5793(95)00687-5.||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||FEBS Lett. 1995 Jul 17;368(2):331-5. doi: 10.1016/0014-5793(95)00687-5.||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||FEBS Lett
. 1995 Jul 17;368(2):331-5. doi: 10.1016/0014-5793(95)00687-5.||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed||Raschig J et al., 2017||Kraemer BF et al. 2011 PLoS Pathog Nov 7|||Pongo pygmaeus (Bornean orangutan)||Immunogenetics. 2002 Feb;53(10-11):907-913.Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.|||FEBS Lett. 1995 Jul 17;368(2):331-5. PubMed"	36	
FPDB00048	AP00473|||AP00473|||Piscidins p1|||Piscidin-1|||Moronecidin|||DRAMP02330|||AP00473|||AP00473|||Piscidin-1	FFHHIFRGIVHVGKTIHRLVTG	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anti-MRSA||Hemolytic||Anticancer||Anti-E. coli, activity value is MIC = 12.5 uM||Anti-P. aeruginosa, activity value is MIC = 50 uM||Anti-B. subtilis, activity value is MIC = 12.5 uM||Anti-and S. aureus USA300 or MRSA, activity value is MIC = 1||Antibacterial||Anti-Enterococcus faecalis VRE, activity value is MIC = 5||Anti-E. faecalis, activity value is MIC = 2.5||Anti-Listeria monocytogenes, activity value is MIC = 2.5||Anti-Micrococcus luteus, activity value is MIC = 10||Anti-Staphylococcus aureus MRSA, activity value is MIC = 1.25||Anti-S. epidermitis, activity value is MIC = 5||Anti-S. saprophiticus, activity value is MIC = 5||Anti-Staphylococcus xylosus, activity value is MIC > 20 uM||Anti-S. agalactiae, activity value is MIC = 1.25||Anti-S. bovis, activity value is MIC = 1.25||Anti-S. equisimilis, activity value is MIC = 2.5||Anti-S. mitis, activity value is MIC = 1.25||Anti-S. Pneumonae, activity value is MIC = 1.25||Anti-S. pyrogenes, activity value is MIC = 1.25||Anti-Streptococcus iniae KST740 ak, activity value is MIC = 1.25||Anti-S. iniae KSTSi 6P, activity value is MIC = 1.25||Anti-Aeromonas hydrophila, activity value is MIC > 20 uM||Anti-Burkholderia cepacia, activity value is MIC > 20 uM||Anti-Vibrio Cholera, activity value is MIC = 2.5||Anti-Escherichia coli, activity value is MIC = 5||Anti-Enterobacter cloacae, activity value is MIC = 10||Anti-E. Aerogenes, activity value is MIC = 10||Anti-Klebsiella pneumoniae, activity value is MIC = 2.5||Anti-K. oxytoca, activity value is MIC = 5||Anti-Salmonella choleraesuis, activity value is MIC = 10||Anti-S. typhimurium, activity value is MIC = 10||Anti-S. arizonae, activity value is MIC = 10||Anti-Serratia marcescens, activity value is MIC > 20 uM||Anti-Shigella flexneri, activity value is MIC = 2.5||Anti-S. sonnei, activity value is MIC = 5||Anti-Yersinia enterocolitica, activity value is MIC = 2.5||Anti-Neurospora crassa, activity value is MIC = 1.56||Anti-A. fumigatus, activity value is MIC = 50||Anti-F. axysporum, activity value is MIC = 0.78||Anti-F. culmorum, activity value is MIC = 0.39||Anti-C. ablicans, activity value is MIC = 10||Anti-C. glabrata, activity value is MIC = 10||Anti-C. lusitania, activity value is MIC = 10||Anti-C. tropacalis, activity value is MIC = 10||Anti-Escherichia coli, activity value is MIC = 3.1 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 25 ug/ml||Anti-Clinical strain of colistin-resistant A. baumannii, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 1.5 ug/ml||Anti-Clinical strain of methicillin resistant Staphylococcus aureus, activity value is MIC = 3.1 ug/ml	mainly mast cells, gill, skin, intestine, spleen, and anterior kidney, hybrid striped bass (Morone saxatilis x Morone chrysops); Morone saxatilis|||mainly mast cells, gill, skin, intestine, spleen, and anterior kidney, hybrid striped bass (Morone saxatilis x Morone chrysops); Morone saxatilis|||Hybrid striped bass|||Morone chrysops x Morone saxatilis|||Lates calcarifer [Asian sea bass]|||Morone saxatilis (Striped bass)|||mainly mast cells, gill, skin, intestine, spleen, and anterior kidney, hybrid striped bass (Morone saxatilis x Morone chrysops); Morone saxatilis|||mainly mast cells, gill, skin, intestine, spleen, and anterior kidney, hybrid striped bass (Morone saxatilis x Morone chrysops); Morone saxatilis|||Morone chrysops x Morone saxatilis	Helix	"The document provides information on the hemolytic properties of piscidins (fish-derived antimicrobial peptide) only through the hemolytic activity comparison curve (Figure 1c), without clearly indicating a specific 50% hemolytic concentration (HC₅₀) value. The core comparison results are as follows: 
 
1. Trends in Hemolytic Activity of Major Peptides (Testing Human Red Blood Cells)
 
piscidins (P1, P2, P3): Hemolytic activity increases with concentration, all higher than the antibacterial peptide magainin 2 but lower than the metin peptide mellitin (mellitin has weaker antibacterial activity but stronger hemolytic activity). 
Among them, piscidin 3 is the member with the lowest hemolytic activity in the piscidin family, and its structure is speculated to be related — histidine (His) at position 17 is replaced by glycine (Gly), disrupting amphiphilic α-helix structure, reducing amphiphilic activity, and thereby weakening hemolytic ability. 
Magainin 2 (control, sourced from the clawed toad): At the same concentration, hemolytic rates were significantly lower than all piscidins. 
mellitin (control, source of bee venom): At the same concentration, its hemolytic rate is significantly higher than all piscidins, making it the peptide with the strongest hemolytic activity among the three. 
 
2. Key Points
 
The document only shows relative hemolysis capacity using the ""concentration-hemolysis rate"" curve (horizontal axis 1-1000 μg/ml, vertical axis 0%-100%), without providing precise hemolysis rate values corresponding to specific concentrations (such as hemolysis percentage at a certain concentration), nor calculating and recording HC₅₀ (the peptide concentration causing 50% hemolysis of red blood cells) as a core quantitative indicator.|||The document provides some hemolytic values, as follows:

- Piscidins 1-3: At concentrations of 1-1000 μg/ml, there are differences in hemolysis rates on human red blood cells. Among them, piscidin 3 has a relatively lower hemolysis rate, which may be related to the substitution of histidine at position 17 in its structure with glycine, disrupting the amphipathic α-helix structure.
- Magainin 2: The hemolytic activity is lower than that of piscidins, and the hemolysis rate is relatively low within the same concentration range.
- Melittin: The hemolytic activity is relatively strong, with a higher hemolysis rate at higher concentrations, but its antibacterial activity is comparatively weaker.

These data indicate that the hemolytic activity of different peptide antibiotics is closely related to structural features, and the integrity of the amphipathic α-helix may be an important factor affecting hemolytic activity.|||Human RBCs (100% hemolysis at 100 ug/ml)|||human RBC ( 57 ug/ml)|||In Document 10 (NATURE 2001), piscidin family antimicrobial peptides (piscidin 1, piscidin 2, piscidin 3) isolated from the tissues of hybrid striped bass (Morone saxatilis × M. chrysops) exhibit hemolytic activity, with hemolytic capacity stronger than magainin 2 derived from Xenopus but weaker than melittin; among them, piscidin 3 has the lowest hemolytic activity, and its hemolytic ability is related to the integrity of the amphipathic α-helical structure.|||The document mentions the hemolytic data of piscidins, magainin 2, and mellitin, as follows:

- Piscidins 1-3 (P1, P2, P3): At a concentration of 1 µg/ml, the hemolysis rate is close to 0; at 10 µg/ml, the hemolysis rate is about 10%-30% (with P3 having the lowest hemolysis rate); at 100 µg/ml, the hemolysis rate is about 40%-70%; at 1000 µg/ml, the hemolysis rate is about 70%-90%.

- Magainin 2 (Mag 2): Hemolysis is lower than that of piscidins, with a hemolysis rate of about 40% at 1000 µg/ml.

- Mellitin: The most hemolytic, showing some hemolysis even at 1 µg/ml, and almost 100% hemolysis at 100 µg/ml.

The above data are presented in Figure 1c (human red blood cell hemolytic activity curve), showing the hemolysis percentages of each peptide at different concentrations.|||Human RBCs (100% hemolysis at 100 ug/ml)"	"Nature 2001; 414, 268 - 269; doi:10.1038/35104690. (PubMed)|||Silphaduang U, Noga E.J.2001
 Nature 2001; 414, 268 - 269; doi:10.1038/35104690. (PubMed)||Kim JP et al 2010|||Nature 2001; 414, 268 - 269; doi:10.1038/35104690.||Kim JP et al 2010|||Nature 2001; 414, 268 - 269; doi:10.1038/35104690. (PubMed)|||Nature
. 2001 Nov 15;414(6861):268-9. doi: 10.1038/35104690.||Kim JP et al 2010|||31653020|||31354312, 30021422|||30365554|||Nature. 2001 Nov 15;414(6861):268-269.||Ref.11713517|||Nature 2001; 414, 268 - 269; doi:10.1038/35104690. (PubMed)||Kim JP et al 2010|||Nature 2001; 414, 268 - 269; doi:10.1038/35104690. (PubMed)|||31354312, 30021422||Refer PubMed ID: 30021422"	22	
FPDB00049	AP00497|||AP00497|||Maximin-H5|||DRAMP01127	ILGPVLGLVSDTLDDVLGIL	Anti-Gram+||Antiviral||Anti-HIV||Anticancer||Anti-S. aureus, activity value is MIC = 90 uM||Anti-T98G, activity value is EC50 = 125 uM||Antibacterial ; Bombina maxima [Giant fire-bellied toad]||Antibacterial||Antimicrobial	Bombina maxima, China, Asia|||Bombina maxima, China, Asia|||Bombina maxima [Giant fire-bellied toad]|||Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	N/A	"Hemolytic assay was tested with rabbit red cells
in liquid medium as reported [12]. Serial dilutions of the peptides were
used, and after incubation at 37 _x0002_C for 0.5 h, the cells were centri-fuged
and the absorbance in the supernatant was measured at 595 nm.
Maximum hemolysis was determined by adding 1% Triton X-100 to a
sample of cells.|||In the hemolysis experiment targeting the anionic antimicrobial peptide Maximin H5 from the toad (Bombina maxima), no hemolysis of rabbit red blood cells was observed at a concentration as high as 80 μM, that is, the hemolytic value was: no hemolysis at a concentration of 80 μM."	"Biochem Biophys Res Commun 2002 Jul 26;295(4):796-9|||Lai R, Liu H, Hui Lee W, Zhang Y.2002
 Biochem Biophys Res Commun 2002 Jul 26;295(4):796-9||Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346|||Biochem Biophys Res Commun 2002 Jul 26;295(4):796-9|||Biochem Biophys Res Commun 2002 Jul 26;295(4):796-9|||https://pubmed.ncbi.nlm.nih.gov/12127963|||Biochem Biophys Res Commun 2002 Jul 26;295(4):796-799."	20	
FPDB00051	AP00505|||AP00505|||Histatin5|||DRAMP03580|||Histatin5|||AP00505|||DRAMP03580	DSHAKRHHGYKRKFHEKHHSHRGY	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Enzyme inhibitor||Anti-C. albicans, activity value is LD50 = 2.3 ug/ml||Anti-and E. faecium . Also active against bacteria A.actinomycetemcomitans, activity value is ED50 > 100 uM||Anti-S. mutans cariogenic bacteria, activity value is ED50 = 92 uM||Anti-C. albicans DIS or azole resistant, activity value is ED50 = 6.4||Anti-C. glabrata or fluconazole resistant, activity value is ED50 = 38.7||Anti-C. krusei, activity value is ED50 = 6.47 uM||Anti-and C. neoformans CN2 or amphotericin B resistant, activity value is ED50 = 3.71||Anti-and S. cerevisiae, activity value is MIC = 74 uM||Antibacterial||Antimicrobial||Anti-Streptococcus mutans U159, activity value is MIC = 234 ug/ml||Anti-Candida albicans ATCC10231, activity value is IC50 = 8.5 ug/ml||Anti-31417503: C. albicans ATCC 90028, activity value is MIC = 64.45 ug/ml||Anti-11302797: Candida albicans, activity value is LD50 = 7.3	salivary glands, Homo sapiens|||salivary glands, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||Homo sapiens [Human]|||salivary glands, Homo sapiens|||Homo sapiens (Human)	Helix||Alpha helix	Streptococcus mutans U159 (MIC= 234 ug/ml), Candida albicans ATCC10231 (IC50= 8.5 ug/ml); Refer PubMed ID- 31417503: C. albicans ATCC 90028 (MIC = 64.45 ug/ml); Refer PubMed ID- 11302797: Candida albicans (LD50 = 7.3 ± 0.52 ug/ml); Refer PubMed ID- 3286634: C. albicans ( 100 % inhibition at 54 nmol)	J Biol Chem. 1988 Jun 5;263(16):7472-7.|||J Biol Chem. 1988 Jun 5;263(16):7472-7.||Data from ref for AP504||Du H et al., 2017||Luque-Ortega et al., 2008|||J Biol Chem. 1988 Jun 5;263(16):7472-7.||Data from ref for AP504||Du H et al., 2017||Luque-Ortega et al., 2008|||34417532, 33740624, 31417503, 11302797, 3286634|||J Biol Chem. 1988 Jun 5;263(16):7472-7477.|||34417532, 33740624, 31417503, 11302797, 3286634|||J Biol Chem. 1988 Jun 5;263(16):7472-7.||Data from ref for AP504||Du H et al., 2017||Luque-Ortega et al., 2008|||J Biol Chem. 1988 Jun 5;263(16):7472-7477.	24	
FPDB00052	AP00512|||DRAMP01047|||Shepherin II|||AP00512|||DRAMP01047	GYHGGHGGHGGGYNGGGGHGGHGGGYNGGGHHGGGGHG	"Anti-Gram-||Antiviral||Antifungal||Anti-HIV
Crucial residues:||Anti-Gram- E. herbicola, activity value is IC50 = 25 ug/ml||Anti-E. coli, activity value is IC50 < 2.5 ug/ml||Anti-P. putida, activity value is IC50 < 2.5 ug/ml||Anti-P. syringae, activity value is IC50 < 2.5 ug/ml||Anti-S. typhimurium, activity value is IC50 = 65 ug/ml||Anti-Serratia sp, activity value is IC50 < 2.5 ug/ml||Anti-B.subtilis, activity value is IC50 > 100 ug/ml||Anti-S.aureus, activity value is IC50 > 100 ug/ml||Anti-S.mutans, activity value is IC50 > 100 ug/ml||Anti-C. albicans, activity value is IC50 = 5 ug/ml||Anti-C. neoformans, activity value is IC50 < 2.5 ug/ml||Anti-S. cerevisiae, activity value is IC50 = 3 ug/ml||Anti-A.alternata, activity value is IC50 > 100 ug/ml||Anti-A. flavus, activity value is IC50 = 60 ug/ml||Anti-A.fumigatus, activity value is IC50 > 100 ug/ml||Anti-and F. culmorum, activity value is IC50 = 68 ug/ml||Antimicrobial||Antibacterial||Antifungal ; Erwinia herbicola (IC(50) = 25 ug/ml)||Escherichia coli (IC(50) < 2.5 ug/ml)||Pseudomonas putida (IC(50) < 2.5 ug/ml)||Pseudomonas syringae (IC(50) < 2.5 ug/ml)||Salmonella typhimurium (IC(50) = 65 ug/ml)||Serratia sp. (IC(50) < 2.5 ug/ml)||Candida albicans (IC(50) = 5 ug/ml)||Cryptococcus neoformans (IC(50) < 2.5 ug/ml)||Saccharomyces cerevisiae (IC(50) = 3 ug/ml)||Aspergillus flavus (IC(50) = 60 ug/ml)||Fusarium culmorum (IC(50) = 68 ug/ml)||Anti-HIV"	roots, shepherd's purse, Capsella bursa-pastoris|||roots, shepherd's purse, Capsella bursa-pastoris|||Capsella bursa-pastoris (shepherd's purse)|||Capsella bursa-pastoris [Shepherd purse]|||roots, shepherd's purse, Capsella bursa-pastoris|||Capsella bursa-pastoris (shepherd's purse)	Rich	N/A	"Plant Mol Biol. 2000 Sep;44(2):187-97. Pub-Med.|||Plant Mol Biol. 2000 Sep;44(2):187-97.  doi: 10.1023/a:1006431320677.|||Plant Mol Biol
. 2000 Sep;44(2):187-97. doi: 10.1023/a:1006431320677.|||Plant Mol Biol. 2000 Sep;44(2):187-197.|||11117262|||Plant Mol Biol. 2000 Sep;44(2):187-97. Pub-Med.|||Plant Mol Biol. 2000 Sep;44(2):187-197."	38	
FPDB00053	AP00524|||AP00524|||HBD2|||Human beta-defensin-2 WT hBD - 2|||AP00524|||DRAMP03598	" 
GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Chemotactic||Anti-toxin||Channel inhibitors||Synergistic AMPs||Antibiofilm||Wound healing||Anti-synthetic: Active against E. coli DSM1103, activity value is MIC = 18.8 ug/ml||Anti-K. pneumoniae DSM681, activity value is MIC = 37.5 ug/ml||Anti-P. aeruginosa DSM1128, activity value is MIC = 25 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 100 ug/ml||Anti-and S.pneumoniae DSM11865, activity value is MIC = 300 ug/ml||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	airway, skin, lung, trachea epithelia, and uterus, oral (saliva); Homo sapiens|||airway, skin, lung, trachea epithelia, and uterus, oral (saliva); Homo sapiens|||Synthetic construct|||Homo sapiens [Human]|||airway, skin, lung, trachea epithelia, and uterus, oral (saliva); Homo sapiens|||Homo sapiens (Human)	Combine Helix and Beta structure	[Ref.15625724] It is slightly hemolytic (<12%) against human erythrocytes at the highest concentration of 500 ug/ml.	"Nature. 1997 Jun 26;387(6636):861. PubMed.|||1997 Jun 26;387(6636):861. doi: 10.1038/43088.||see ref AP1315|||Nature. 1997 Jun 26;387(6636):861. doi: 10.1038/43088.|||Nature
. 1997 Jun 26;387(6636):861. doi: 10.1038/43088.||see ref AP1315|||9727055|||Nature. 1997 Jun 26;387(6636):861. PubMed.|||Nature. 1997 Jun 26;387(6636):861.J Biol Chem. 2000 Oct 20;275(42):32911-32918.Plant Cell Rep. 2007 Aug;26(8):1391-1398."	41	
FPDB00054	AP00532|||AP00532|||Lunatusin|||DRAMP01010|||Lunatusin|||AP00532|||DRAMP01010|||AP00532|||DRAMP01010	KTCENLADTFRGPCFATSNC	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anticancer||Anti-a minor component that is not present in the glandular secretion of the female. Activity against B.cereus, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 6 uM||Anti-L. innocua, activity value is MIC = 50 ug/ml||Anti-M. luteus, activity value is MIC = 25 ug/ml||Anti-or 29213, activity value is MIC > 100 ug/ml||Anti-S. epidermidis, activity value is MIC = 100 ug/ml||Anti-S. uberis, activity value is MIC = 50 ug/ml||Antibacterial||Antifungal ; Phaseolus lunatus L [Lima bean]||Antimicrobial||Anti-Gram+||Anti-Gram-||Antifungal ; Fusarium oxysporum||Mycosphaerella arachidicola||Botrytis cinerea||Bacillus megaterium||Bacillus subtilis||Proteus vulgaris||Mycobacterium phlei	Phaseolus lunatus L. (lima bean)|||Phaseolus lunatus L. (lima bean)|||Phaseolus lunatus L [Lima bean]|||Phaseolus lunatus L.(Chinese lima bean)|||Phaseolus lunatus L. (lima bean)|||Phaseolus vulgaris cv. white cloud beans|||Phaseolus lunatus L. (lima bean)|||Phaseolus lunatus L.(Chinese lima bean)	N/A	No hemolysis information or data found in the reference(s) presented in this entry	"Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.|||Jack Ho Wong and Tzi Bun Ng2005
 Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.||same ref as AP2008||VanCompernolle et al., 2015|||Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.|||Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.|||https://pubmed.ncbi.nlm.nih.gov/16269344|||Peptides. 2005 Nov;26(11):2086-2092.|||16269344|||Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.|||Peptides. 2005 Nov;26(11):2086-2092.|||Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25.|||Peptides. 2005 Nov;26(11):2086-2092."	20	
FPDB00055	AP00553|||AP00553|||Sesquin|||DRAMP00409|||Sesquin|||AP00553|||DRAMP00409|||AP00553|||CAMPSQ7|||DRAMP00409	" 
KTCENLADTY"	Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-HIV||Anticancer||Active against fungi B. cinerea||F.oxysporum||and M. arachidicola. Inhibit leukemia cells M1 and breast cancer cells MCF-7. HIV (50 uM inhibit 35%).||Anti-Botrytis cinerea, activity value is IC50 = 2.5 uM||Anti-Fusarium oxysporum, activity value is IC50 = 1.4 uM||Anti-Mycosphaerella arachidicola, activity value is IC50 = 0.15 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral ; N.A	Seeds, Vigna sesquipedalis, ground bean|||Seeds, Vigna sesquipedalis, ground bean|||Synthetic construct|||Vigna unguiculata subsp. sesquipedalis (Yard-Long bean)|||Vigna unguiculata subsp. sesquipedalis|||Seeds, Vigna sesquipedalis, ground bean|||Vigna unguiculata subsp. sesquipedalis (Yard-Long bean)|||Seeds, Vigna sesquipedalis, ground bean|||Vigna unguiculata subsp. sesquipedalis  [Cowpea]|||Vigna unguiculata subsp. sesquipedalis (Yard-Long bean)	N/A	No hemolysis information or data found in the reference(s) presented in this entry	"Peptides. 2005 Jul;26(7):1120-6|||Wong JH, Ng TB2005
 Peptides. 2005 Jul;26(7):1120-6|||Peptides. 2005 Jul;26(7):1120-6|||Peptides. 2005 Jul;26(7):1120-6|||15949629|||Peptides. 2005 Jul;26(7):1120-1126.|||http://www.ncbi.nlm.nih.gov/protein/109894868|||Peptides. 2005 Jul;26(7):1120-6|||Peptides. 2005 Jul;26(7):1120-1126.|||Peptides. 2005 Jul;26(7):1120-6|||15949629|||Peptides. 2005 Jul;26(7):1120-1126."	10	
FPDB00056	AP00590|||Siamycin II|||AP00590|||DRAMP18350|||Siamycin II	" 
CLGIGSCNDFAGCGYAIVCFW"	Antiviral||Anti-HIV||Anti-Staphylococcus aureus FDA209P JC-1, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus smith, activity value is MIC = 6.3 ug/ml||Anti-Staphylococcus aureus A15036, activity value is MIC = 3.1 ug/ml||Anti-Micrococcus luteus ATCC 9341, activity value is MIC = 1.6 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 1.6 ug/ml||Anti-Escherichia coli Juhl, activity value is MIC > 100 ug/ml||Anti-E. coli K12, activity value is MIC > 100 ug/ml||Anti-E. coli NIHJ JC-2, activity value is MIC > 100 ug/ml||Anti-K. pneumoniae ATCC 10031, activity value is MIC > 100 ug/ml||Anti-Citrobacter freundii GN 7391, activity value is MIC > 100 ug/ml||Anti-Salmonella typhi 901, activity value is MIC > 100 ug/ml||Anti-P. aeruginosa A9843A, activity value is MIC > 100 ug/ml||Antimicrobial||Antiviral ; HIV-1	Streptomyces strains AA3891|||Streptomyces strain AA6532	Beta||Beta strand	No hemolysis information or data found in the reference(s) presented in this entry	J Biomol NMR. 1995 Apr;5(3):271-86. PubMed.|||J Biomol NMR. 1995 Apr;5(3):271-86. doi: 10.1007/BF00211754.|||8557614|||J Biomol NMR. 1995 Apr;5(3):271-86. PubMed.|||J Biomol NMR. 1995 Apr;5(3):271-86.|||7787424	21	
FPDB00057	AP00599|||AP00599|||Brevinin-2-related peptide|||DRAMP01873|||Brevinin-2-related peptide|||AP00599|||DRAMP01873	GIWDTIKSMGKVFAGKILQNL	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Anti-E. coli, activity value is MIC = 13||Anti-S. aureus or MRSA, activity value is MIC = 25 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Anti-Escherichia coli, activity value is MIC = 13 uM||Anti-Staphylococcus aureus, activity value is MIC = 25 uM||Anti-Candida albicans, activity value is MIC = 25 uM||Anti-19793185 : E. coli, activity value is MIC = 6.25 uM||Anti-S. aureus, activity value is MIC = 12.5 uM||Anti-A. baumannii, activity value is MIC = 6.25 uM||Anti-31549575 : Staphylococcus aureus, activity value is MIC = 16||Anti-Escherichia coli, activity value is MIC = 32 uM||Anti-Candida albicans, activity value is MIC = 16 uM||Anti-Candida albicans, activity value is MIC = 70 uM	mink frog, Rana septentrionalis, North America|||Rana septentrionalis (mink frog)|||mink frog, Rana septentrionalis, North America|||Rana septentrionalis (mink frog)	N/A	"The document explicitly provides the hemolytic values of five major antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), expressed as the concentration required to induce 50% hemolysis of human red blood cells (HC₅₀). The specific data are as follows:

Brevinin-1SPa: The hemolytic concentration HC₅₀ is 7 μM, and its minimum inhibitory concentrations (MICs) against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans) are 13 μM, 3 μM, and 6 μM, respectively.
Brevinin-1SPb: hemolytic activity, HC₅₀ = 25 μM; MIC values against Escherichia coli, Staphylococcus aureus, and Candida albicans are 50 μM, 6 μM, and 13 μM, respectively.
Brevinin-1SPd: hemolytic activity HC₅₀ = 8 μM; the MIC values against Escherichia coli, Staphylococcus aureus, and Candida albicans are all 3 μM.
Temporin-1SPb: hemolytic activity, HC₅₀ = 60 μM; only a MIC of 6 μM against Staphylococcus aureus was detected, while the MICs against Escherichia coli and Candida albicans were not determined (ND).
Brevinin-2-related peptide: hemolytic activity, HC₅₀ = 70 µM; MIC values against Escherichia coli, Staphylococcus aureus, and Candida albicans are 13 µM, 25 µM, and 25 µM, respectively.|||The document mentioned hemolysis-related content, and the specific hemolytic values are as follows:

- Brevinin-1SPa: The concentration causing 50% hemolysis of human red blood cells (HC₅₀) is 7 μM.
- Brevinin-1SPb: HC₅₀ is 25 μM.
- Brevinin-1SPd: HC₅₀ is 8 μM.
- Temporin-1SPb: HC₅₀ is 60 μM.
- Brevinin-2 related peptides: HC₅₀ is 71 μM.|||Human erythrocytes ( HC50 = 70 uM ); Refer PubMed ID - 19793185: hRBC(LC50= 90 uM)|||In Document 2 (Comparative Biochemistry and Physiology, Part C 2004), among the antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), brevinin-1SPa has an HC₅₀ of 7 μM for human red blood cells, brevinin-1SPb has an HC₅₀ of 25 μM, brevinin-1SPd has an HC₅₀ of 8 μM, temporin-1SPb has an HC₅₀ of 60 μM, and brevinin-2 related peptide has an HC₅₀ of 70 μM.|||[Ref.15556063]HC50=70 uM against human erythrocytes|||Human erythrocytes ( HC50 = 70 uM ); Refer PubMed ID - 19793185: hRBC(LC50= 90 uM)|||[Ref.15556063]HC50=70 uM against human erythrocytes|||The document mentions the hemolytic activity values of several antimicrobial peptides isolated from the skin secretions of the mink frog (Rana septentrionalis), expressed as HC_{50}, which is the peptide concentration causing 50% hemolysis. The details are as follows:

- Brevinin-1SPa: HC_{50} = 7 μM

- Brevinin-1SPb: HC_{50} = 25 μM

- Brevinin-1SPd: HC_{50} = 8 μM

- Temporin-1SPb: HC_{50} = 60 μM

- Brevinin-2-related peptide: HC_{50} = 70 μM

These values reflect the hemolytic capability of different peptides on human red blood cells; the lower the value, the stronger the hemolytic activity."	Comp. Biochem. Physiol. C 2004; 139: 31-38|||omp. Biochem. Physiol. C 2004; 139: 31-38|||15556063, 19793185, 31549575|||Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.||Ref.15556063|||15556063||Ref.15556063|||15556063, 19793185, 31549575|||Comp. Biochem. Physiol. C 2004; 139: 31-38|||Ref.15556063	21	
FPDB00058	AP00640|||AP00640|||Maculatin-1.3|||DRAMP01366|||AP00640|||DRAMP01366	" 
GLLGLLGSVVSHVVPAIVGHF"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anticancer||Anti-S. aureus USA300 MRSA, activity value is MIC = 6.2 uM||Anti-E.coli, activity value is MIC > 100 uM||Anti-B. subtilis, activity value is MIC = 25 uM||Anti-and P.aeruginosa, activity value is MIC > 100 uM||Anti-MRSA||Antibacterial||Antimicrobial	Anti-Gram+ & Gram-, Antiviral, Anti-HIV, Anticancer|||Litoria eucnemis, Australia|||Litoria eucnemis, Australia|||Litoria eucnemis, Australia|||Litoria eucnemis [Australian anurans]|||Litoria eucnemis (Australian anurans)|||Litoria eucnemis, Australia|||Litoria eucnemis (Australian anurans)	N/A	"The document clearly provides the hemolytic values of two types of peptides in the skin secretions of the European common frog (Rana temporaria) (expressed as the concentration causing hemolytic effect on human red blood cells). The specific data are as follows:

1. Brevinin-1 family peptides
Brevinin-1T, Brevinin-1Ta: They have hemolytic activity, but the document does not provide specific concentration values, only mentioning that both have dual antibacterial and hemolytic activity and were initially isolated from the skin secretions of the European common frog.
Brevinin-1Tb: No clear hemolytic value is provided; it is only mentioned that it has antibacterial activity against Staphylococcus aureus (concentration 7.6 uM) and no activity against Salmonella enterica serovar typhimurium, with no hemolytic data mentioned.
New Brevinin-1Tc (specific to the Slovenian population): Hemolytic values have not been directly measured, but its bioactivity is inferred to be similar to that of Brevinin-1T, 1Ta, and 1Tb through 2D mass spectrometry mapping (NMD-NIS coordinates), potentially having hemolytic activity, but the specific concentration is unknown.

2. Melittin-related peptides (MRP-1)
Hemolytic value: Lethal concentration (LC) for human red blood cells is 0.5 uM, which is a potent hemolytic agent, present in both Moscow and Slovenian populations, and can serve as a species biomarker for the European common frog.

3. Temporin family peptides
Known temporins (A, B, L, etc.): Only described as having ""low"" hemolytic activity (for example, temporins A and B are active against Gram-positive bacteria and fungi but have weak hemolytic activity) or mentioning that temporin L has hemolytic activity against human red blood cells, with no specific HC_{50} or LC values provided.
Six new temporins (O, P, Q, R, S, T, specific to the Slovenian population): Bioactivity inferred through 2D mass spectrometry mapping:
Short-chain new temporins (O, T): Similar activity to temporins A and B, low hemolytic activity, no specific values;
Long-chain new temporins (Q, R, S): Activity similar to temporin L (which has hemolytic activity), but no specific hemolytic concentration measured;
temporin P: Due to the absence of basic amino acid residues in the sequence, it is inferred to have no hemolytic activity or extremely weak activity, with no specific values.|||The document only mentions the hemolytic information of caerin 1.1, specifically: caerin 1.1 lyses red blood cells at >250 μg/ml, meaning that the peptide lyses red blood cells at concentrations above 250 μg/ml, but does not specify the exact hemolytic values such as the half-maximal hemolytic concentration (HC₅₀). 

For other antimicrobial peptides (such as aureins, citropins, maculatins, etc.), the descriptions mainly involve antibacterial, anticancer, antifungal activities, and do not mention hemolytic values.|||No hemolysis information or data found in the reference(s) presented in this entry"	Peptides. 2004 Jun;25(6):1035-54.|||Peptides. 2004 Jun;25(6):1035-54|||Peptides. 2004 Jun;25(6):1035-54.||Menousek et al., 2012|||Peptides. 2004 Jun;25(6):1035-54.|||Peptides. 2004 Jun;25(6):1035-54||Menousek et al., 2012|||15203252|||Peptides. 2004; 25: 1035-1054.|||Peptides. 2004 Jun;25(6):1035-54.|||Peptides. 2004; 25: 1035-1054.	21	
FPDB00059	AP00663|||DRAMP01517|||AP00663|||DRAMP01517	GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC	Anti-Gram-||Antiviral||Anti-HIV||Anti-Escherichia coli, activity value is MIC = 10 uM||Antimicrobial||Antibacterial	North American frog, Rana pipiens|||Rana pipiens (northern leopard frog)|||North American frog, Rana pipiens|||Rana pipiens (northern leopard frog)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||No hemolysis information or data found in the reference(s) presented in this entry	"Eur J Biochem. 2000 Feb;267(3):894-900. PubMed.|||Eur J Biochem. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Eur J Biochem
. 2000 Feb;267(3):894-900. doi: 10.1046/j.1432-1327.2000.01074.x.|||Ref.10651828||Ref.11601906|||Eur J Biochem. 2000 Feb;267(3):894-900. PubMed.|||Virology. 2001 Sep 30;288(2):351-7.Eur J Biochem. 2000 Feb;267(3):894-900."	37	
FPDB00060	AP00706	GLLASLGKVFGGYLAEKLKPK	Anti-Gram+ & Gram-||Antiviral||Anti-HIV	Litoria dahlii, Australia	N/A	N/A	"Rapid Commun Mass Spectrom. 2001;15(18):1726-34. PubMed.|||Rapid Commun Mass Spectrom. 2001;15(18):1726-34. doi: 10.1002/rcm.429.|||Rapid Commun Mass Spectrom
. 2001;15(18):1726-34. doi: 10.1002/rcm.429."	21	
FPDB00061	AP00708|||AP00708|||GF-17|||GI-17	GFKRIVQRIKDFLRNLV	Anti-Gram+ & Gram-||Antiviral||Spermicidal||Anti-HIV||Anti-MRSA||Synergistic AMPs||Anticancer||Anti-and S. aureus USA300 MRSA, activity value is MIC = 3.1||Anti-E. faecium ATCC 51559, activity value is MIC = 3.1 uM||Anti-S. aureus USA300, activity value is MIC = 3.1 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 3.1 uM||Anti-A. baumannii B28-16, activity value is MIC = 3.1 uM||Anti-P. aeruginosa PAO1, activity value is MIC = 12.5 uM||Anti-E. cloacae B2366-1, activity value is MIC = 3.1 uM||Anti-S. aureus Newman, activity value is MIC = 1.6 uM||Anti-S. aureus Mu50, activity value is MIC = 1.6 uM||Anti-S. aureus UAMS1, activity value is MIC = 3.1 uM||Anti-E. faecium V284-17, activity value is MIC = 2 uM||Anti-S. aureus USA300, activity value is MIC = 2||Anti-A. baumannii B28-16, activity value is MIC = 4 uM||Anti-P. aeruginosa E411-17, activity value is MIC = 16 uM||Anti-E. coli E423-17, activity value is MIC = 16 uM	Derivative of LL-37; NMR-based discovery; Sequence truncation. human cathelicidin analog, animal-derived, natural derivative|||Derivative of LL-37; NMR-based discovery; Sequence truncation. human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct	Helix	Moderate hemolytic activity (55% hemolysis at 50 μM)|||Human RBCs [Hemolytic concentration (HL50) = 180 uM]|||Human RBC (65% hemolysis at 200 uM)	"J Am Chem Soc. 2006 May 3;128(17):5776-85. PubMed.|||J Am Chem Soc. 2006 May 3;128(17):5776-85. PubMed|||J Am Chem Soc. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875.||Golla R. et al., 2020|||J Am Chem Soc. 2006 May 3;128(17):5776-85. PubMed.|||J Am Chem Soc
. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875.||Golla R. et al., 2020|||31319057|||34959645"	17	
FPDB00062	AP00724|||AP00724|||RTD-2|||DRAMP31352|||AP00724|||DRAMP31352	" 
GVCRCLCRRGVCRCLCRR"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Antibacterial||Antimicrobial	Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta (Rhesus macaque)	Bridge	Strong hemolytic activity (100% hemolysis at 5 μM)	J Leukoc Biol 2001; 70:461-464|||J Leukoc Biol 2001; 70:461-464|||11675394|||J Immunol. 2004 Jul 1;173(1):515-20.|||J Leukoc Biol 2001; 70:461-464|||J Immunol. 2004 Jul 1;173(1):515-20.	18	
FPDB00063	AP00725|||AP00725|||Rhesus theta defensin-1/3, subunit A precursor|||DRAMP31353|||AP00725|||Rhesus theta defensin-1/3, subunit A precursor|||DRAMP31353	" 
GFCRCICTRGFCRCICTR"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-toxin||Antibacterial||Antimicrobial||Antiviral ; Staphylococcus aureus 502a||Escherichia coli ML35||and yeast forms of Candida albicans 16820 and Cryptococcus neoformans 271A||HIV	Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)|||Bone marrow, or blood leukocytes, rhesus monkey, Macaca mulatta|||Macaca mulatta [Rhesus macaque]|||Macaca mulatta (Rhesus macaque)	Bridge	Strong hemolytic activity (100% hemolysis at 5 μM)	J Leukoc Biol 2001; 70:461-464|||J Leukoc Biol 2001; 70:461-464|||11675394|||J Immunol. 2004 Jul 1;173(1):515-20.|||J Leukoc Biol 2001; 70:461-464|||https://pubmed.ncbi.nlm.nih.gov/11675394|||J Immunol. 2004 Jul 1;173(1):515-20.	18	
FPDB00064	AP00764|||AP00764|||Dermaseptin-S9|||DRAMP01682	GLRSKIWLWVLLMIWQESNKFKKM	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Chemotactic||Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 31.6 uM||Antibacterial||Antimicrobial	South America, hylid frog, Phyllomedusa sauvagei|||South America, hylid frog, Phyllomedusa sauvagei|||Phyllomedusa sauvagei [Sauvage's leaf frog]|||Phyllomedusa sauvagei (South American hylid frog)	Helix	N/A	Biochemistry 2006; 45: 468-480|||Biochemistry 2006; 45: 468-480|||16401077|||Biochemistry. 2006 Jan 17;45(2):468-480.	24	
FPDB00065	AP00729|||Kalata B1|||DRAMP00856|||Kalata B1|||AP00729|||DRAMP00856|||AP00729|||DRAMP00856|||Kalata B1	GLPVCGETCVGGTCNTPGCTCSWPVCTRN	Anti-Gram+ & Gram-||Antiviral||Antifungal||Insecticidal||Anti-HIV||Enzyme inhibitor||Hemolytic||Anti-Gram- E.coli, activity value is MIC > 500 uM||Anti-P.aeruginosa, activity value is MIC > 500 uM||Anti-P.vulgaris, activity value is MIC > 500 uM||Anti-K. oxytoca, activity value is MIC = 54.8 uM||Anti-S. aureus, activity value is MIC = 0.26 uM||Anti-M. luteus, activity value is MIC = 40.4 uM||Anti-C.albicans, activity value is MIC > 500 uM||Anti-C. kefyr, activity value is MIC = 21.4 uM||Anti-and C.tropicalis, activity value is MIC > 500 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC > 500 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 500 uM||Anti-Proteus vulgaris ATCC 49132, activity value is MIC > 500 uM||Anti-Klebsiella oxytoca ATCC 49131, activity value is MIC = 54.8 uM||Anti-Staphylococcus aureus 29213, activity value is MIC = 0.26 uM||Anti-Micrococcus luteus ATCC 49732, activity value is MIC = 40.4 uM||Anti-Candida albicans ATCC 37092, activity value is MIC > 500 uM||Anti-Candida kefyr ATCC 37095, activity value is MIC = 21.4 uM||Anti-Candida tropicalis ATCC 37097, activity value is MIC > 500 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 40 uM||Anti-Staphylococcus aureus, activity value is MIC = 0.26 uM||Anti-Micrococcus luteus, activity value is MIC = 40.4 uM||Anti-Klebsiella oxytoca, activity value is MIC = 54.8 uM||Anti-Candida kefyr, activity value is MIC = 21.4 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-HIV, activity value is EC50 = 0.66 uM	African herb, Oldenlandia affinis|||Oldenlandia affinis|||Oldenlandia affinis|||African herb, Oldenlandia affinis|||African herb, Oldenlandia affinis|||Oldenlandia affinis|||Viola yedoensis	Beta||Beta strand (3 strands; 7 residues)	"Human blood type A erythrocytes|||The half-hemolysis concentrations (the concentrations causing 50% hemolysis) of four cyclotides (kalata, circulin A, circulin B, cyclopsychotride) on human erythrocytes are all greater than 400 μM, among which circulin B and cyclopsychotride have relatively higher hemolytic activities, with half-hemolysis concentrations of 550 μM and 405 μM, respectively, while the half-hemolysis concentrations of kalata and circulin A are 1510 μM and 1020 μM, respectively.|||[Ref.12779323] HD50 = 300 uM against Human type A red blood cells.|||Human blood type A erythrocytes|||EC₅₀=1510 uM|||[Ref.12779323] HD50 = 300 uM against Human type A red blood cells.|||The document mentions the hemolytic values of four cyclotides (kalata, circulin A, circulin B, cyclopsychotride), as follows:

- The concentration at which all four cyclotides cause 50% hemolysis of human red blood cells is greater than 400 μM.

- Among them, circulin B and cyclopsychotride have relatively higher hemolytic activity, with 50% hemolysis concentrations of 550 μM and 405 μM, respectively; kalata and circulin A have lower hemolytic activity, with 50% hemolysis concentrations of 1510 μM and 1020 μM, respectively.

These data come from hemolysis experiments, in which the hemolytic effects of different concentrations of peptides on human type A red blood cells were measured, and the 50% hemolysis concentration (EC₅₀) was determined from the dose-response curve.|||[Ref.12779323] HD50 = 300 uM against Human type A red blood cells."	Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8.PubMed.|||Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8.doi: 10.1073/pnas.96.16.8913.||see ref|||10430870|||28669767|||Biopolymers. 2008;90(1):51-60.||Ref.10430870|||18008336||Ref.10430870||Ref.18008336|||10430870|||Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8.PubMed.||see ref|||Ref.10430870||Ref.18008336|||Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8.PubMed.|||Biopolymers. 2008;90(1):51-60.Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.Biochemistry. 1995 Apr 4;34(13):4147-4158.J Biol Chem. 2012 Dec 21;287(52):43884-98.|||https://pubmed.ncbi.nlm.nih.gov/18081258	29	
FPDB00066	AP00730|||DRAMP00863|||AP00730|||DRAMP00863|||Kalata-B8	GSVLNCGETCLLGTCYTTGCTCNKYRVCTKD	Antiviral||Anti-HIV||Hemolytic||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 2.5 uM||Antimicrobial||Antiviral ; HIV	African herb, Oldenlandia affinis|||Staphylococcus warneri ISK-1|||African herb, Oldenlandia affinis|||Oldenlandia affinis	Beta||Beta strand (3 strands; 7 residues)	[Ref.20564013] It produced 7% hemolysis at the 62 uM.	Biochem J 2006; 393: 619-626|||Biosci Biotechnol Biochem. 2000 Nov;64(11):2420-8.Vet Microbiol. 2010 Nov 20;146(1-2):124-31.|||Biochem J 2006; 393: 619-626|||Biopolymers. 2008;90(1):51-60.Biochem J. 2006 Feb 1;393(Pt 3):619-626.Chembiochem. 2007 Jun 18;8(9):1001-1011.|||https://pubmed.ncbi.nlm.nih.gov/16207177	31	
FPDB00067	AP01022|||DRAMP00799|||AP01022|||DRAMP00799|||Cycloviolin-A	" 
GVIPCGESCVFIPCISAAIGCSCKNKVCYRN"	Antiviral||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.13 uM||Antimicrobial	Leonia cymosa|||Clitoria ternatea (Butterfly pea)|||Leonia cymosa|||Leonia cymosa (Sacha uba)	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Org Chem. 2000 Jan 14;65(1):124-8|||J Biol Chem. 2011 Jul 8;286(27):24275-24287.|||J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10813905	31	
FPDB00068	AP01023|||DRAMP00800|||AP01023|||DRAMP00800|||Cycloviolin-B	GTACGESCYVLPCFTVGCTCTSSQCFKN	Antiviral||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.13 uM||Antimicrobial||Antiviral ; HIV	Leonia cymosa|||Clitoria ternatea (Butterfly pea)|||Leonia cymosa|||Leonia cymosa (Sacha uba)|||Synthetic construct	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Org Chem. 2000 Jan 14;65(1):124-8|||J Biol Chem. 2011 Jul 8;286(27):24275-24287.|||J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10813905	28	
FPDB00069	AP01024|||DRAMP00801|||AP01024|||DRAMP00801|||Cycloviolin-C	GIPCGESCVFIPCLTTVAGCSCKNKVCYRN	Antiviral||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.13 uM||Antimicrobial	Leonia cymosa|||Leonia cymosa (Sacha uba)|||Leonia cymosa|||Leonia cymosa (Sacha uba)	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10813905	30	
FPDB00070	AP01025|||DRAMP00802|||AP01025|||DRAMP00802|||Cycloviolin-D	" 
GFPCGESCVFIPCISAAIGCSCKNKVCYRN"	Antiviral||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.13 uM||Antimicrobial	Leonia cymosa|||Leonia cymosa (Sacha uba)|||Leonia cymosa|||Leonia cymosa (Sacha uba)	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||J Org Chem. 2000 Jan 14;65(1):124-8|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10813905	30	
FPDB00071	AP01030|||AP01030|||DRAMP00788|||Varv E	" 
GLPICGETCVGGTCNTPGCSCSWPVCTRN"	Antiviral||Anti-HIV||Hemolytic||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.35 uM||Anti-cancer||Anti-HIV, activity value is EC50 = 0.35 uM	Viola arvensis|||Viola arvensis|||Viola arvensis (European field pansy) (Field violet)|||Viola yedoensis	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 1999 Feb;62(2):283-6. Pub-Med.|||J Nat Prod. 1999 Feb;62(2):283-6. doi: 10.1021/np9803878.||Ireland et al., 2008|||J Nat Prod. 1999 Feb;62(2):283-6. Pub-Med.|||Biopolymers. 2008;90(1):51-60.J Nat Prod. 1999 Feb;62(2):283-286.J Nat Prod. 2004 Feb;67(2):144-147.Peptides. 2010 Aug;31(8):1434-40|||https://pubmed.ncbi.nlm.nih.gov/18081258	29	
FPDB00072	AP01034|||DRAMP00803|||AP01034|||DRAMP00803	" 
GDPTFCGETCRVIPVCTYSAALGCTCDDRSDGLCKRN"	Antiviral||Anti-HIV||Antimicrobial	Palicourea condensata|||Leonia cymosa (Sacha uba)|||Palicourea condensata|||Palicourea condensata (Cappel)	Combine Helix and Beta structure||Combine helix and strand structure	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2001 Feb;64(2):249-50.|||J Org Chem. 2000 Jan 14;65(1):124-128.Biopolymers. 2008;90(1):51-60.|||J Nat Prod. 2001 Feb;64(2):249-50.|||J Nat Prod. 2001 Feb;64(2):249-250.Structure. 2004 Jan;12(1):85-94.Biopolymers. 2008;90(1):51-60.	37	
FPDB00073	AP01058|||DRAMP00875|||AP01058|||DRAMP00875|||Vhl-1	" 
SISCGESCAMISFCFTEVIGCSCKNKVCYLN"	Antiviral||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.87 uM||Antimicrobial	Viola hederaceae|||Macadamia integrifolia (Macadamia nut)|||Viola hederaceae|||Viola hederacea (Australian violet)|||Viola hederacea	Combine Helix and Beta structure||Combine helix and strand structure	No hemolysis information or data found in the reference(s) presented in this entry	J Biol Chem. 2005 Jun 10;280(23):22395-405. Pub-Med.|||J Biol Chem. 2005 Jun 10;280(23):22395-405. doi: 10.1074/jbc.M501737200. Epub 2005 Apr 11.||Ireland et al., 2008|||Plant J. 1999 Sep;19(6):699-710.|||J Biol Chem. 2005 Jun 10;280(23):22395-405. Pub-Med.|||Biopolymers. 2008;90(1):51-60.J Biol Chem. 2005 Jun 10;280(23):22395-22405.|||https://pubmed.ncbi.nlm.nih.gov/15824119	31	
FPDB00074	AP01060|||DRAMP00879|||AP01060|||DRAMP00879|||Circulin C	GIPCGESCVFIPCITSVAGCSCKSKVCYRN	Antiviral||Anti-HIV||Anti-HIV-1 strain IIIB/CEM-SS cell, activity value is EC50 = 0.073 uM||Anti-H1122 strain/MT-2 cell, activity value is EC50 = 0.048 uM||Anti-and A17 strain/MT-2, activity value is EC50 = 0.247 uM||Antimicrobial||Anti-HIV-1, activity value is EC50 = 50	tropical tree Chassalia parvifolia|||Viola hederacea (Australian violet)|||tropical tree Chassalia parvifolia|||Chassalia parviflora|||Chassalia parvifolia	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-8. doi: 10.1021/np990432r.|||J Biol Chem. 2005 Jun 10;280(23):22395-22405.Aust. J. Chem. 2010;63:771-778.|||J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10691702	30	
FPDB00075	AP01061|||DRAMP00880|||AP01061|||DRAMP00880|||Circulin D	" 
KIPCGESCVWIPCVTSIFNCKCKENKVCYHD"	Antiviral||Anti-HIV||Circulins C-F showed anti HIV-1 effect with EC50 values (concentration for 50% inhibition) in the range from 50 to 0.275 uM||depending upon the particular virus strain and host cell line used in the assay.||Antimicrobial||Anti-HIV-1, activity value is EC50 = 50	tropical tree Chassalia parvifolia|||Chassalia parviflora|||tropical tree Chassalia parvifolia|||Chassalia parviflora|||Chassalia parvifolia	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-8. doi: 10.1021/np990432r.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10691702	31	
FPDB00076	AP01062|||DRAMP00881|||AP01062|||DRAMP00881|||Circulin-E	" 
KIPCGESCVWIPCLTSVFNCKCENKVCYHD"	Antiviral||Anti-HIV||Circulins C-F showed anti HIV-1 effect with EC50 values (concentration for 50% inhibition) in the range from 50 to 0.275 uM||depending upon the particular virus strain and host cell line used in the assay.||Antimicrobial	tropical tree Chassalia parvifolia|||Chassalia parviflora|||tropical tree Chassalia parvifolia|||Chassalia parviflora	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-8. doi: 10.1021/np990432r.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10691702	30	
FPDB00077	AP01063|||DRAMP00882|||AP01063|||DRAMP00882|||Circulin F	KVCYRAIPCGESCVWIPCISAAIGCSCKN	Antiviral||Anti-HIV||Circulins C-F showed anti HIV-1 effect with EC50 values (concentration for 50% inhibition) in the range from 50 to 0.275 uM||depending upon the particular virus strain and host cell line used in the assay.||Antimicrobial||Anti-HIV-1, activity value is EC50 = 50	tropical tree Chassalia parvifolia|||Chassalia parviflora|||tropical tree Chassalia parvifolia|||Chassalia parviflora|||Chassalia parvifolia	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-8. doi: 10.1021/np990432r.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||J Nat Prod. 2000 Feb;63(2):176-8. Pub-Med.|||J Nat Prod. 2000 Feb;63(2):176-178.Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/10691702	29	
FPDB00078	AP01064|||AP01064|||DRAMP00816|||DRAMP00816	" 
GIPCGESCVWIPCISAAIGCSCKSKVCYRN"	Antiviral||Antifungal||Antiparasitic||Anti-HIV||Active against nematode parasites of sheep (e.g. Haemonchus contortus or Trichostrongylus colubriformis).||Insecticidal	Viola odorata|||Viola odorata|||Viola odorata (Sweet violet)|||Viola odorata (Sweet violet)	Bridge	"Peptides were dissolved in water and serially diluted in PBS to give 0.02 ml test solutions in a 96-well U-bottomed microtitre plate (Nunc). Human type A RBCs (red blood cells) were washed with PBS and centrifuged at 1500000000 ug for 60 s in a microcentrifuge several times until a clear supernatant was obtained. A 0.25% suspension of washed RBCs in PBS (0.1 ml) was added to the peptide solutions. The plate was incubated at 37◦Cfor 1 h and centrifuged at 150000000 ug for 0.083333 h. Aliquots of 0.1 mlweretransferred to a 96-well flat-bottomed microtitre plate (Falcon) and the absorbance was measured at 405 nm with an automatic Multiskan Ascent plate reader (Labsystems). The amount of haemolysis was calculated as the percentage ofmaximum lysis (1%Triton X-100 control) after adjusting for minimum lysis (PBS control). Synthetic melittin (Sigma) was used for comparison. The haemolytic dose necessary to lyse 50% of the RBCs (HD50) was calculated using the regression constant from the linear portion of the haemolytic titration curve (Graphpad Prism software).|||The document mentions hemolysis-related data for various cyclic peptides isolated from Viola odorata, as follows:

- cycloviolacin O2: At a concentration of 25 µM, the hemolysis rate is about 40%, and the half-hemolysis concentration (HD_{50}) is about 36 µM.

- cycloviolacin O13: At a concentration of 25 µM, the hemolysis rate is about 60%, and the HD_{50} is about 11 µM.

- cycloviolacin O14: At a concentration of 25 µM, the hemolysis rate is about 11%, making it the cyclic peptide with the lowest hemolysis among the new peptides.

- cycloviolacin O15: At a concentration of 25 µM, the hemolysis rate is about 25%.

- cycloviolacin O24: At a concentration of 25 µM, the hemolysis rate is about 75%, making it the cyclic peptide with the highest hemolysis among the new peptides.

- varv A: At a concentration of 25 µM, the hemolysis rate is about 50%.

- kalata B1: At a concentration of 25 µM, the hemolysis rate is about 30%.

These data were obtained through hemolysis experiments using human type A red blood cells as the experimental subject, with 1% Triton X-100 treated group as the maximum hemolysis control and PBS treated group as the minimum hemolysis control, and the hemolysis percentage was calculated accordingly.|||[Ref:16872274] It has 50% hemolytic activity at 1 uM and 75% hemolytic activity at 1.5 uM against human type A red blood cells|||[Ref:16872274] It has 50% hemolytic activity at 1 uM and 75% hemolytic activity at 1.5 uM against human type A red blood cells"	Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12. doi: 10.1042/BJ20060627.|||Biochem J. 2006 Nov 15;400(1):1-12.Biopolymers. 2008;90(1):51-60.	30	
FPDB00079	AP01065|||AP01065|||DRAMP00817|||DRAMP00817	GSIPACGESCFKGKCYTPGCSCSKYPLCAKN	Antiviral||Antiparasitic||Anti-HIV||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.44 uM||Insecticidal	Viola odorata|||Viola odorata|||Viola odorata (Sweet violet)|||Viola odorata (Sweet violet)	Combine||Combine helix and strand structure	"The document mentions hemolysis-related data for various cyclic peptides isolated from Viola odorata, as follows:

- cycloviolacin O2: At a concentration of 25 µM, the hemolysis rate is about 40%, and the half-hemolysis concentration (HD_{50}) is about 36 µM.

- cycloviolacin O13: At a concentration of 25 µM, the hemolysis rate is about 60%, and the HD_{50} is about 11 µM.

- cycloviolacin O14: At a concentration of 25 µM, the hemolysis rate is about 11%, making it the cyclic peptide with the lowest hemolysis among the new peptides.

- cycloviolacin O15: At a concentration of 25 µM, the hemolysis rate is about 25%.

- cycloviolacin O24: At a concentration of 25 µM, the hemolysis rate is about 75%, making it the cyclic peptide with the highest hemolysis among the new peptides.

- varv A: At a concentration of 25 µM, the hemolysis rate is about 50%.

- kalata B1: At a concentration of 25 µM, the hemolysis rate is about 30%.

These data were obtained through hemolysis experiments using human type A red blood cells as the experimental subject, with 1% Triton X-100 treated group as the maximum hemolysis control and PBS treated group as the minimum hemolysis control, and the hemolysis percentage was calculated accordingly.|||[Ref:16872274] It has 3% hemolytic activity at 1 uM and 13% hemolytic activity at 1.5 uM against human type A red blood cells|||[Ref:16872274] It has 3% hemolytic activity at 1 uM and 13% hemolytic activity at 1.5 uM against human type A red blood cells"	Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12. doi: 10.1042/BJ20060627.||Ireland et al., 2008|||Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12.Biopolymers. 2008;90(1):51-60.|||Biochem J. 2006 Nov 15;400(1):1-12.Biopolymers. 2008;90(1):51-60.	31	
FPDB00080	AP01066|||AP01066|||DRAMP00828	GLPTCGETCFGGTCNTPGCTCDPWPVCTHN	Antiviral||Anti-HIV||Hemolytic||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.308 uM||Insecticidal	Viola odorata|||Viola odorata|||Viola odorata (Sweet violet)	Bridge	"The document mentions hemolysis-related data of cyclic peptides isolated from Viola yedoensis, as follows:

- Kalata B1: half-hemolysis concentration (HD_{50}) is 11.7 µM, 95% confidence interval 10.2–13.4 µM.

- Cycloviolacin Y4: HD_{50} is 9.3 µM, 95% confidence interval 7.7–11.1 µM.

- Cycloviolacin Y5: HD_{50} is 8.7 µM, 95% confidence interval 7.4–10.2 µM.

- Cycloviolacin Y1: within the tested concentration range, hemolysis is significantly lower than the above cyclic peptides and is the lowest among them.

- Melittin (positive control): HD_{50} is 0.94 µM, 95% confidence interval 0.9–0.97 µM, with hemolysis much higher than the tested cyclic peptides.

These data were obtained via hemolysis experiments using human type A red blood cells, with 1% Triton X-100 treatment as the maximum hemolysis control and PBS treatment as the minimum hemolysis control, and the hemolysis percentage was calculated.|||[Ref:16872274] It has 75% hemolytic activity at 25 uM against human type A red blood cells."	Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12. doi: 10.1042/BJ20060627.||Ireland et al., 2008|||Biochem J. 2006 Nov 15;400(1):1-12. Pub-Med.|||Biochem J. 2006 Nov 15;400(1):1-12.Biopolymers. 2008;90(1):51-60.|||Biochem J. 2006 Nov 15;400(1):1-12.##Biopolymers. 2008;90(1):51-60.	30	
FPDB00081	AP01077|||DRAMP00833|||AP01077|||DRAMP00833|||Cycloviolacin Y1	" 
GGTIFDCGETCFLGTCYTPGCSCGNYGFCYGTN"	Antiviral||Anti-HIV||Hemolytic||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 1.21 uM||Antimicrobial||Anti-HIV, activity value is EC50 = 1.2 uM	Chinese herb Viola yedoensis and Viola odorata|||Pelophylax esculentus (Edible frog) (Rana esculenta)|||Chinese herb Viola yedoensis and Viola odorata|||Viola yedoensis (Chinese herb)|||Viola yedoensis	Bridge	"The document mentions hemolysis-related data of cyclic peptides isolated from Viola yedoensis, as follows:

- Kalata B1: half-hemolysis concentration (HD_{50}) is 11.7 µM, 95% confidence interval 10.2–13.4 µM.

- Cycloviolacin Y4: HD_{50} is 9.3 µM, 95% confidence interval 7.7–11.1 µM.

- Cycloviolacin Y5: HD_{50} is 8.7 µM, 95% confidence interval 7.4–10.2 µM.

- Cycloviolacin Y1: within the tested concentration range, hemolysis is significantly lower than the above cyclic peptides and is the lowest among them.

- Melittin (positive control): HD_{50} is 0.94 µM, 95% confidence interval 0.9–0.97 µM, with hemolysis much higher than the tested cyclic peptides.

These data were obtained via hemolysis experiments using human type A red blood cells, with 1% Triton X-100 treatment as the maximum hemolysis control and PBS treatment as the minimum hemolysis control, and the hemolysis percentage was calculated.|||[Ref.18081258] It has hemolytic activity.|||Human type A erythrocytes ( IC50 > 4.5 uM )"	J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52. doi: 10.1021/np70393000000 ug. Epub 2007 Dec 15.||Ireland et al., 2008|||J. Biol. Chem. 269:11956-11961(1994)|||J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52.  Biopolymers. 2008;90(1):51-60.|||https://pubmed.ncbi.nlm.nih.gov/18081258	33	
FPDB00082	AP01080|||DRAMP00836|||AP01080|||DRAMP00836|||Cycloviolacin Y4	" 
GVPCGESCVFIPCITGVIGCSCSSNVCYLN"	Antiviral||Anti-HIV||Hemolytic||Antimicrobial||Anti-HIV, activity value is EC50 = 0.12 uM	Chinese herb Viola yedoensis and Viola odorata|||Chinese herb Viola yedoensis|||Viola hederacea (Australian violet)|||Chinese herb Viola yedoensis|||Viola yedoensis (Chinese herb)|||Viola yedoensis	Bridge	"The document mentions hemolysis-related data of cyclic peptides isolated from Viola yedoensis, as follows:

- Kalata B1: half-hemolysis concentration (HD_{50}) is 11.7 µM, 95% confidence interval 10.2–13.4 µM.

- Cycloviolacin Y4: HD_{50} is 9.3 µM, 95% confidence interval 7.7–11.1 µM.

- Cycloviolacin Y5: HD_{50} is 8.7 µM, 95% confidence interval 7.4–10.2 µM.

- Cycloviolacin Y1: within the tested concentration range, hemolysis is significantly lower than the above cyclic peptides and is the lowest among them.

- Melittin (positive control): HD_{50} is 0.94 µM, 95% confidence interval 0.9–0.97 µM, with hemolysis much higher than the tested cyclic peptides.

These data were obtained via hemolysis experiments using human type A red blood cells, with 1% Triton X-100 treatment as the maximum hemolysis control and PBS treatment as the minimum hemolysis control, and the hemolysis percentage was calculated.|||[Ref:18081258] HD50=9.3 uM against human type A red blood cells."	J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52. doi: 10.1021/np70393000000 ug. Epub 2007 Dec 15.|||J Mol Biol. 1999 Dec 17;294(5):1327-1336.|||J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52.Biopolymers. 2008;90(1):51-60.Chembiochem. 2008 Aug 11;9(12):1939-45. doi: 10.1002/cbic.200800174.|||https://pubmed.ncbi.nlm.nih.gov/18081258	30	
FPDB00083	AP01081|||DRAMP00837|||AP01081|||DRAMP00837|||Cycloviolacin Y5	GIPCAESCVWIPCTVTALVGCSCSDKVCYN	Antiviral||Anti-HIV||Hemolytic||Anti-It inhibited HIV-1 infection in cultured human T-lymphoblast cells, activity value is EC50 = 0.04 uM||Antimicrobial||Anti-HIV, activity value is EC50 = 0.04 uM	Chinese herb Viola yedoensis and Viola odorata|||Chinese herb Viola yedoensis|||Viola yedoensis (Chinese herb)|||Chinese herb Viola yedoensis|||Viola yedoensis (Chinese herb)|||Viola yedoensis	Bridge	"The document mentions hemolysis-related data of cyclic peptides isolated from Viola yedoensis, as follows:

- Kalata B1: half-hemolysis concentration (HD_{50}) is 11.7 µM, 95% confidence interval 10.2–13.4 µM.

- Cycloviolacin Y4: HD_{50} is 9.3 µM, 95% confidence interval 7.7–11.1 µM.

- Cycloviolacin Y5: HD_{50} is 8.7 µM, 95% confidence interval 7.4–10.2 µM.

- Cycloviolacin Y1: within the tested concentration range, hemolysis is significantly lower than the above cyclic peptides and is the lowest among them.

- Melittin (positive control): HD_{50} is 0.94 µM, 95% confidence interval 0.9–0.97 µM, with hemolysis much higher than the tested cyclic peptides.

These data were obtained via hemolysis experiments using human type A red blood cells, with 1% Triton X-100 treatment as the maximum hemolysis control and PBS treatment as the minimum hemolysis control, and the hemolysis percentage was calculated.|||[Ref:18081258] HD50=8.7 uM against human type A red blood cells."	J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52. doi: 10.1021/np70393000000 ug. Epub 2007 Dec 15.||Ireland et al., 2008|||J Nat Prod. 2008 Jan;71(1):47-52.Biopolymers. 2008;90(1):51-60.Chembiochem. 2008 Aug 11;9(12):1939-45. doi: 10.1002/cbic.200800174.|||J Nat Prod. 2008 Jan;71(1):47-52. Pub-Med.|||J Nat Prod. 2008 Jan;71(1):47-52.  Biopolymers. 2008;90(1):51-60.Chembiochem. 2008 Aug 11;9(12):1939-45. doi: 10.1002/cbic.200800174.|||https://pubmed.ncbi.nlm.nih.gov/18081258	30	
FPDB00084	AP01136|||AP01136|||Tricyclon A	GGTIFDCGESCFLGTCYTKGCSCGEWKLCYGTN	Anti-Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-E.coli, activity value is MIC = 160 uM||Anti-P. aeruginosa, activity value is MIC = 80 uM||Anti-S.aureus, activity value is MIC = 160 uM||Anti-C. albicans, activity value is MIC = 80 uM||Antibacterial	Australian flowers, Viola tricolor|||Australian flowers, Viola tricolor|||Viola odorata L. and Viola tricolor L	Beta	"Under specific hemolysis experimental conditions, after incubating 500 uM of tricyclon A with red blood cells at 37°C for 1 hour, the hemolysis rate was only 2%; under the same conditions, about 100 uM of kalata B1 resulted in a hemolysis rate of 50%. The HD50 of kalata B1 at 37°C is 100 uM, while tricyclon A exhibits very low hemolytic activity.|||The document mentions hemolytic-related data for tricyclon A and kalata B1, as follows:

- Tricyclon A: At a concentration of 500 µM, after incubation at 37°C for 1 hour, it only caused 2% hemolysis of red blood cells, indicating very low hemolytic activity.

- Kalata B1 (for comparison): Under the same experimental conditions, the half-hemolysis concentration (HD_{50}) is about 100 µM, meaning the concentration that causes 50% hemolysis of red blood cells is 100 µM.

These data were obtained through hemolysis experiments using human type A red blood cells as the experimental subject, with a 1% Triton X-100 treatment group as the maximum hemolysis control and a PBS treatment group as the minimum hemolysis control. The hemolysis percentage was calculated accordingly."	Structure. 2005 May;13(5):691-701|||Structure. 2005 May;13(5):691-701||Strömstedt et al., 2017|||Structure. 2005 May;13(5):691-701|||28669767	33	
FPDB00085	AP01137|||AP01137|||Siamycin I|||AP01137|||DRAMP18349|||Siamycin I	CLGVGSCNDFAGCGYAVVCFW	Anti-Gram+||Antiviral||Anti-HIV||Anti-Gram+ bacteria WT S. aureus ATCC29213, activity value is MIC = 3.7 uM||Anti-Staphylococcus aureus FDA209P JC-1, activity value is MIC = 3.1 ug/ml||Anti-Staphylococcus aureus smith, activity value is MIC = 6.3 ug/ml||Anti-Staphylococcus aureus A15036, activity value is MIC = 3.1 ug/ml||Anti-Micrococcus luteus ATCC 9341, activity value is MIC = 1.6 ug/ml||Anti-Bacillus subtilis ATCC 6633, activity value is MIC = 1.6 ug/ml||Anti-Escherichia coli Juhl, activity value is MIC > 100 ug/ml||Anti-E. coli K12, activity value is MIC > 100 ug/ml||Anti-E. coli NIHJ JC-2, activity value is MIC > 100 ug/ml||Anti-K. pneumoniae ATCC 10031, activity value is MIC > 100 ug/ml||Anti-Citrobacter freundii GN 7391, activity value is MIC > 100 ug/ml||Anti-Salmonella typhi 901, activity value is MIC > 100 ug/ml||Anti-P. aeruginosa A9843A, activity value is MIC > 100 ug/ml||Antimicrobial	Streptomyces strain AA6532	Beta||Beta strand	No hemolysis information or data found in the reference(s) presented in this entry	J Antibiot (Tokyo). 1995 Dec;48(12):1515-7|||J Antibiot (Tokyo). 1995 Dec;48(12):1515-7|||8557614|||J Antibiot (Tokyo). 1995 Dec;48(12):1515-7|||J Antibiot (Tokyo). 1995 Dec;48(12):1515-7.|||8557614	21	
FPDB00086	AP01138|||AP01138|||DRAMP18347|||NP-06	CLGVGSCNDFAGCGYAIVCFW	Antiviral||Anti-HIV||Antimicrobial||Anti-HIV-1LAI, activity value is IC50 = 2.8 uM||Anti-HIV 2ROD, activity value is IC50 = 6 uM||Anti-HIV-1ERS104pre, activity value is IC50 = 1.3 uM	Streptomyces strain AA6532|||Streptomyces strain AA6532|||Streptomyces sp. No. 73264	Bridge	No hemolysis information or data found in the reference(s) presented in this entry	Antimicrob Agents Chemother. 1995 Oct;39(10):2345-7|||Antimicrob Agents Chemother. 1995 Oct;39(10):2345-7|||Antimicrob Agents Chemother. 1995 Oct;39(10):2345-7.|||8619594	21	
FPDB00087	AP01184|||DRAMP31009|||AP01184|||Mucroporin-M1|||DRAMP31009	" 
LFRLIKSLIKRLVSAFK"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-Mucroporin-M1 is active against E. coli AB94012, activity value is MIC = 12.5 ug/ml||Anti-P. aeruginosa AB93066, activity value is MIC = 100 ug/ml||Anti-B. thuringiensis AB92037, activity value is MIC = 25 ug/ml||Anti-B. subtilis AB91021, activity value is MIC = 25 ug/ml||Anti-S. aureus AB94004, activity value is MIC = 5 ug/ml||Anti-clincal stain 1538 as well as HIV-1. Also active against measles McV, activity value is EC50 = 7.15 ug/ml||Anti-SARS-CoV, activity value is EC50 = 14.46 ug/ml||Anti-and influenza A virus H5N1, activity value is EC50 = 2.1 ug/ml||Anti-measles virus :inhibition of MeV infection in Vero cells, activity value is EC50 = 7.15 ug/ml||Anti-SARS-CoV :inhibition of SARS-CoV infection in MDCK cells, activity value is EC50 = 14.46 ug/ml||Anti-H5N1 :inhibition of H5N1 infection in MDCK cells, activity value is EC50 = 2.1 ug/ml||Anti-Measles virus, activity value is EC50 = 7.15 ug/ml||Anti-H5N1, activity value is EC50 = 2.1 ug/ml||Antimicrobial	Enterococcus faecium T8|||animal-derived, natural derivative|||Enterococcus faecium T8|||Synthetic construct(derived from Mucroporin)|||Enterococcus faecium T8|||Synthetic construct|||Synthetic construct(derived from Mucroporin)	N/A	BACTER	Appl Environ Microbiol. 2006 Jul;72(7):4761-6|||Appl Environ Microbiol. 2006 Jul;72(7):4761-6||Li et al., 2011|||Ref.21620914|||Appl Environ Microbiol. 2006 Jul;72(7):4761-6|||https://pubmed.ncbi.nlm.nih.gov/26492266,|||Peptides. 2011 Jul;32(7):1518-25.	17	
FPDB00088	AP01207|||AP01207|||Retrocyclin-1	GICRCICGRGICRCICGR	Antiviral||Anti-HIV||Anti-toxin||Antiviral ; HIV-1	mammal theta-defensin; Derived from a silent human gene (pre-stop), animal-derived, natural derivative|||mammal theta-defensin; Derived from a silent human gene (pre-stop), animal-derived, natural derivative|||Synthetic construct	Bridge	N/A	Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1813-8|||Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1813-8|||https://pubmed.ncbi.nlm.nih.gov/15210812	18	
FPDB00089	AP01208|||AP01208|||Retrocyclin-2	" 
GICRCICGRRICRCICGR"	Antiviral||Anti-HIV||Anti-toxin||RC2 is most active against primary isolates of HIV-1. The molecule can self associate in water in a concentration dependent manner.||Antiviral ; HIV-1	mammal theta-defensin; Derived from a silent human gene (pre-stop), animal-derived, natural derivative|||mammal theta-defensin; Derived from a silent human gene (pre-stop), animal-derived, natural derivative|||Synthetic construct	Beta	N/A	J Immunol. 2004 Jul 1;173(1):515-20|||J Immunol. 2004 Jul 1;173(1):515-20|||https://pubmed.ncbi.nlm.nih.gov/15210812	18	
FPDB00090	AP01223|||AP01223|||Ascaphin-8|||Ascaphin-8|||AP01223|||DRAMP01847|||AP01223|||DRAMP01847	"  
GFKDLLKGAAKALVKTVLF"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||Enzyme inhibitor||Anticancer||Anti-E. coli, activity value is MIC = 6 uM||Anti-P. aeruginosa, activity value is MIC = 13 uM||Anti-E. cloacae, activity value is MIC = 6 uM||Anti-K. pneumoniae, activity value is MIC = 6 uM||Anti-S. epidermidis, activity value is MIC = 6 uM||Anti-Streptococcus Group B, activity value is MIC = 6 uM||Anti-E. faecalis, activity value is MIC = 50 uM||Anti-and C. albicans, activity value is MIC = 25 uM||Anti-Escherichia coli, activity value is MIC = 6 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 50 uM||Anti-Enterobacter cloacae, activity value is MIC = 13 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 25 uM||Anti-Proteus mirabilis, activity value is MIC > 100 uM||Anti-S. epidermidis, activity value is MIC = 25 uM||Anti-E. faecalis, activity value is MIC > 100 uM||Anti-Streptococcus Group B, activity value is MIC = 13 uM||Anti-C. albicans, activity value is MIC = 100 uM||Anti-E. coli ATCC25922, activity value is MIC = 3 uM||Anti-S. aureus ATCC25923, activity value is MIC = 3 uM||Anti-E. coli ML35p, activity value is MIC = 1.6 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 3 uM||Anti-S. aureus multiresistant ATCCBAA-44, activity value is MIC = 3 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 12.5 uM||Anti-A549, activity value is IC50 = 33.79 uM||Anti-C4-2B, activity value is IC50 = 42.91 uM||Anti-HEK293T, activity value is IC50 = 53.67 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Ascaphus truei [Coastal tailed frog]|||Ascaphus truei (Coastal tailed frog)|||Coastal Tailed Frog, Ascaphus truei, Pacific Northwest, USA, North America|||Ascaphus truei (Coastal tailed frog)	Helix	"Free acid HC50>200  Amidated HC50=55|||Endogenous peptides:

ascaphin-1: Half-maximal hemolytic concentration (HC_{50}) for human red blood cells >200 μM.

ascaphin-3: HC_{50} >200 μM.

ascaphin-7: HC_{50} >200 μM.

ascaphin-8: HC_{50} is 50 μM.

Synthetic peptides:

ascaphin-1 (free acid form): HC_{50} >200 μM; amidated form: HC_{50} >200 μM.

ascaphin-5 (free acid form): HC_{50} >200 μM.

ascaphin-8 (amidated form): HC_{50} is 55 μM.

The above results were obtained through hemolysis experiments. In the experiments, peptides at different concentrations were incubated with washed human red blood cells for 1 hour, and the degree of hemolysis was measured by absorbance at 450 nm. The 1% Tween 20 treated group was used as the 100% hemolysis control, and HC_{50} was defined as the peptide concentration producing 50% hemolysis.|||Ascaphin-1: HC₅₀ > 200 uM.
Ascaphin-3: HC₅₀ > 200 uM.

Ascaphin-7: HC₅₀ > 200 uM.

Ascaphin-8:

Endogenous Ascaphin-8: HC₅₀ = 50 uM.

Synthetic amidated Ascaphin-8: HC₅₀ = 55 uM.

Ascaphin-5: HC₅₀ > 200 uM.|||Human erythrocytes ( HC50 = 50 uM ); Refer PubMed ID 23094651: Rat RBCs [HC50 = 115 uM], PubMed ID 33932712: Rabbit RBC [HC50 = >100 miroM]|||Human erythrocytes ( HC50 = 50 uM ); Refer PubMed ID 23094651: Rat RBCs [HC50 = 115 uM], PubMed ID 33932712: Rabbit RBC [HC50 = >100 miroM]|||The therapeutic potential of ascaphin-8 as an antiinfective agent is limited by its moderately high haemolytic activity (HC50 ¼ 55 lM) In contrast, ascaphin-1 and ascaphin-5, although displaying high potencies only against Gram-negative bacteria, have very low haemolytic activities (HC50 >200 lM) compared with many other frog skin peptides. By way of comparison, the HC50 values of brevinin-1E from Rana esculenta [22] and temporin L from Rana temporaria [23] are less than 2 lM.|||[Ref.15207717]HC50=50 uM against human erythrocytes|||The document mentions the hemolytic values of various ascaphin peptides (expressed as HC_{50}, which is the peptide concentration that causes 50% hemolysis), as follows:

Hemolytic values of endogenous peptides (Table 1)

- Ascaphin-1: HC_{50} > 200 μM

- Ascaphin-3: HC_{50} > 200 μM

- Ascaphin-7: HC_{50} > 200 μM

- Ascaphin-8: HC_{50} = 50 μM

Hemolytic values of synthetic peptides (Table 2)

- Ascaphin-1 (free acid form): HC_{50} > 200 μM

- Ascaphin-1 (amidated form): HC_{50} > 200 μM

- Ascaphin-5 (free acid form): HC_{50} > 200 μM

- Ascaphin-8 (amidated form): HC_{50} = 55 μM|||[Ref.15207717]HC50=50 uM against human erythrocytes|||hemolytic HC50 50 uM. TC50 2.9 uM in CEM-SS cells(Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346)."	"Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. doi: 10.1016/j.bbrc.2004.05.141.||Menousek J et al 2012 Int J Antimicrob Agents 39:402|||Comparative Study Biochem Biophys Res Commun
. 2004 Jul 16;320(1):170-5. doi: 10.1016/j.bbrc.2004.05.141.|||2004 Jul 16;320(1):170-5. doi: 10.1016/j.bbrc.2004.05.141.||Menousek J et al 2012 Int J Antimicrob Agents 39:402|||15207717, 33932712, 23094651||Refer PubMed ID 23094651|||15207717, 33932712, 23094651||Refer PubMed ID 23094651||Refer PubMed ID 33932712|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed||Menousek J et al 2012 Int J Antimicrob Agents 39:402|||Ref.15207717|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-5. PubMed|||Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175."	19	
FPDB00091	AP01269|||AP01269|||Melectin	" 
GFLSILKKVLPKVMAHMK"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-MRSA||Anti-B. subtilis, activity value is MIC = 0.8 uM||Anti-S. aureus MRSA, activity value is MIC = 6.8||Anti-E. coli, activity value is MIC = 2||Anti-and P. aeruginosa, activity value is MIC = 18.5 uM||Anti-the peptide was found to inhibit Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 4.34 uM||Anti-B.subtilis, activity value is MIC = 0.8 uM||Anti-S.aureus, activity value is MIC = 6.8 uM||Anti-E.coli, activity value is MIC = 2 uM||Anti-P.aeruginosa, activity value is MIC = 18.5 uM	the Cleptoparasitic bee, Melecta albifrons|||the Cleptoparasitic bee, Melecta albifrons|||Melecta albifrons [Cuckoo bee]	Helix	"MEP: The half-maximal hemolytic concentration (LC_{50}) on rat red blood cells is >100 µM, indicating low hemolytic activity. 

MEP-1: LC_{50} is 27.3 µM.

MEP-2: LC_{50} is 22.9 µM.

MEP-3: LC_{50} is 29.7 µM.

MEP-4: LC_{50} is 41.4 µM.

MEP-5, MEP-6, MEP-7, MEP-8, MEP-9, MEP-10: LC_{50} are all >100 µM, showing no significant hemolytic activity.

The above results were obtained through hemolysis experiments, in which peptides at different concentrations were incubated with rat red blood cells at 37°C for 1 hour. Hemolysis was measured by absorbance at 540 nm, with a 0.2% Triton X-100 treated group as the 100% hemolysis control. LC_{50} refers to the peptide concentration that produces 50% hemolysis. The results indicate that the original MEP has the lowest hemolytic activity, whereas analogs in which Pro11 was replaced or deleted (MEP-1 to MEP-4) show significantly increased hemolytic activity.|||The document mentions that the hemolytic concentration (LC₅₀) of natural bee venom peptide Melectin (MEP) is greater than 100 μM, showing extremely low hemolytic activity. In contrast, the hemolytic values of its analogs (such as MEP-1, MEP-2, etc.) range from 22.9 μM to 41.4 μM.|||The hemolytic value LC_{50} of MEP is > 100 μM; the hemolytic value LC_{50} of MEP-1 is 27.3 μM; the hemolytic value LC_{50} of MEP-2 is 22.9 μM; the hemolytic value LC_{50} of MEP-3 is 29.7 μM; the hemolytic value LC_{50} of MEP-4 is 41.4 μM; the hemolytic value LC_{50} of MEP-5 is > 100 μM; the hemolytic value LC_{50} of MEP-6 is > 100 μM; the hemolytic value LC_{50} of MEP-7 is > 100 μM; the hemolytic value LC_{50} of MEP-8 is > 100 μM; the hemolytic value LC_{50} of MEP-9 is > 100 μM; the hemolytic value LC_{50} of MEP-10 is > 100 μM."	"Chembiochem. 2008 Nov 24;9(17):2815-21. PubMed|||Chembiochem. 2008 Nov 24;9(17):2815-21. doi: 10.1002/cbic.200800476.||Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346|||Chembiochem
. 2008 Nov 24;9(17):2815-21. doi: 10.1002/cbic.200800476.|||2008 Nov 24;9(17):2815-21. doi: 10.1002/cbic.200800476.||Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346|||18942691"	18	
FPDB00092	AP01271|||DRAMP01225|||AP01271|||DRAMP01225	GIFPKIIGKGIVNGIKSLAKGVGMKVFKAGLNNIGNTGCNNRDEC	Anti-Gram-||Antiviral||Anti-HIV||Anti-E. coli, activity value is MIC = 6 uM||Anti-but not Staph (S.aureus or C.albicans, activity value is MIC > 200 uM||Antimicrobial||Antibacterial	the crawfish frog, Rana areolata, North America|||the crawfish frog, Rana areolata, North America|||Amolops jingdongensis (Chinese torrent frog)|||the crawfish frog, Rana areolata, North America|||Rana areolata (North American crawfish frog)	N/A	"The document mentions the hemolytic values of various peptides, with the following specific information:
palustrin-3AR: hemolytic concentration (HC₅₀) is 200 µM.
esculentin-1ARa: HC₅₀ is 180 µM.
esculentin-1ARb: HC₅₀ is 120 µM.
ranatuerin-2ARa: HC₅₀ is 100 µM.
ranatuerin-2ARb: HC₅₀ is 150 µM.
temporin-1AR: HC₅₀ is 210 µM.
palustrin-2AR: no significant hemolysis observed at a concentration of 300 µM.|||The hemolytic values of various antimicrobial peptides mentioned in the document (expressed as HC_{50}, the peptide concentration that causes 50% hemolysis of human red blood cells) are as follows:

- Palustrin-3AR: HC_{50} = 200 μM

- Esculentin-1ARa: HC_{50} = 180 μM

- Esculentin-1ARb: HC_{50} = 120 μM

- Ranatuerin-2ARa: HC_{50} = 100 μM

- Ranatuerin-2ARb: HC_{50} = 150 μM

- Palustrin-2AR: HC_{50} > 300 μM

- Temporin-1AR: HC_{50} = 210 μM|||[Ref:12429503] HC50=200 uM against human erythrocytes"	Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. PubMed|||Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. doi: 10.1016/s1570-9639(02)00432-6.|||2002 Nov 19;1601(1):55-63. doi: 10.1016/s1570-9639(02)00432-6.|||Biochimie. 2012 Feb;94(2):328-334.|||Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. PubMed|||Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63.	45	
FPDB00093	AP01273|||DRAMP01475	GLFPKFNKKKVKTGIFDIIKTVGKEAGMDVLRTGIDVIGCKIKGEC	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-E. coli, activity value is MIC = 3 uM||Anti-but not C.albicans, activity value is MIC > 200 uM	the crawfish frog, Rana areolata, North America|||the crawfish frog, Rana areolata, North America|||Rana areolata (crawfish frog)	N/A	"The document mentions the hemolytic values of various peptides, with the following specific information:
palustrin-3AR: hemolytic concentration (HC₅₀) is 200 µM.
esculentin-1ARa: HC₅₀ is 180 µM.
esculentin-1ARb: HC₅₀ is 120 µM.
ranatuerin-2ARa: HC₅₀ is 100 µM.
ranatuerin-2ARb: HC₅₀ is 150 µM.
temporin-1AR: HC₅₀ is 210 µM.
palustrin-2AR: no significant hemolysis observed at a concentration of 300 µM.|||[Ref:12429503] HC50=120 uM against human erythrocytes|||The hemolytic values of various antimicrobial peptides mentioned in the document (expressed as HC_{50}, the peptide concentration that causes 50% hemolysis of human red blood cells) are as follows:

- Palustrin-3AR: HC_{50} = 200 μM

- Esculentin-1ARa: HC_{50} = 180 μM

- Esculentin-1ARb: HC_{50} = 120 μM

- Ranatuerin-2ARa: HC_{50} = 100 μM

- Ranatuerin-2ARb: HC_{50} = 150 μM

- Palustrin-2AR: HC_{50} > 300 μM

- Temporin-1AR: HC_{50} = 210 μM"	"Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. PubMed|||Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. doi: 10.1016/s1570-9639(02)00432-6.|||2002 Nov 19;1601(1):55-63. doi: 10.1016/s1570-9639(02)00432-6.|||[Ref.12429503]Gram-negative bacterium: Escherichia coli (MIC=3 uM);
Gram-positive bacterium: Staphylococcus aureus (MIC=60 uM)."	46	
FPDB00094	AP01348|||AP01348|||Temporin-LTc|||DRAMP01784|||AP01348|||DRAMP01784	" 
SLSRFLSFLKIVYPPAF"	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-Staphylococcus aureus ATCC2592, activity value is MIC = 50 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 50 ug/ml||Anti-Pseudomonas fluorescens ATCC13525, activity value is MIC = 100 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 50 ug/ml||Anti-Pseudomonas fluorescens, activity value is MIC = 100 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae), China, Asia|||Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae), China, Asia|||Hylarana latouchii|||Hylarana latouchii (broad-folded frog)|||Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae), China, Asia|||Hylarana latouchii (broad-folded frog)	N/A	"The document mentions the following values related to hemolysis:

brevinin-1LTa: The median lethal concentration (LD₅₀) for rabbit red blood cells is 1.5 µg/ml, showing strong hemolytic activity.
temporin-LTa: The median lethal concentration (LD₅₀) for rabbit red blood cells is 9 µg/ml, with relatively weak hemolytic activity.
temporin-LTb and temporin-LTc: No significant hemolytic activity was detected at concentrations up to 200 µg/ml.|||Rabbit erythrocytes ( LD50 > 200 ug/ml )|||No hemolysis information or data found in the reference(s) presented in this entry"	Peptides. 2009 Feb;30(2):273-82. Pub-Med.|||Peptides. 2009 Feb;30(2):273-82. doi: 10.1016/j.peptides.2008.10.016. Epub 2008 Nov 5.|||2009 Feb;30(2):273-82. doi: 10.1016/j.peptides.2008.10.016. Epub 2008 Nov 5.|||19022312|||Peptides. 2009 Feb;30(2):273-82. Pub-Med.|||Peptides. 2009 Feb;30(2):273-282.	17	
FPDB00095	AP01434|||AP01434|||Temporin-PTa|||DRAMP01802	FFGSVLKLIPKIL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-MRSA||Antibiofilm||Anti-the natural form was not evaluated due to a low amount of the peptide. A synthetic peptide was found to be active. The L and D-forms of the peptide showed identical antibacterial activity against E. coli, activity value is MIC = 25 uM||Anti-B. subtilis, activity value is MIC = 6.25 uM||Anti-and S. aureus USA300 MRSA, activity value is MIC = 3.1 uM||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	Hylarana picturata, Asia|||Hylarana picturata, Asi|||Rana picturata [Malaysian fire frog]|||Rana picturata (Malaysian fire frog) (Hylarana picturata)	Helix	N/A	"Toxicon. 2008 Sep 1;52(3):465-73. Pub-Med.|||Toxicon. 2008 Sep 1;52(3):465-73. doi: 10.1016/j.toxicon.2008.06.017. Epub 2008 Jun 25.|||Toxicon
. 2008 Sep 1;52(3):465-73. doi: 10.1016/j.toxicon.2008.06.017. Epub 2008 Jun 25.|||2008 Sep 1;52(3):465-73. doi: 10.1016/j.toxicon.2008.06.017. Epub 2008 Jun 25.|||18621071|||Toxicon. 2008 Sep 1;52(3):465-473."	13	
FPDB00096	AP01580|||AP01580|||Elafin	AQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ	Anti-Gram+ & Gram-||Antiviral||Antifungal||Antiparasitic||Anti-HIV||Enzyme inhibitor||Antimalarial||active against P. aeruginosa PAO1 and S. aureus C1705. Active against HIV-1 and HSV-2 (Drannik AG||et al 2013). The anti-HIV activity of Elafin is 130 times more potent than its precursor serine antiprotease trappin-2 (Drannik AG||et al 2012).||Antibacterial ; S. aureus||P. aeruginosa	gammadelta T cells, keratinocytes, epithelial cells, skin, Homo sapiens|||skin, Homo sapiens|||Homo sapiens [Human]	Beta	no hemolytic activity	FEBS Lett. 1999 Jun 11;452(3):309-13. doi: 10.1016/s0014-5793(99)00670-5. PubMed|||FEBS Lett. 1999 Jun 11;452(3):309-13. doi: 10.1016/s0014-5793(99)00670-5.|||Scand J Immunol. 2009 Dec;70(6):547-52|||16336202	57	
FPDB00097	AP01654|||AP01654|||Caerin-1.19|||AP01654|||DRAMP01586	GLFKVLGSVAKHLLPHVAPIIAEKL	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	skin dorsal glands, Australian dainty green tree frog, Litoria gracilenta|||skin dorsal glands, Australian dainty green tree frog, Litoria gracilenta|||Litoria gracilenta [Dainty green tree frog]|||skin dorsal glands, Australian dainty green tree frog, Litoria gracilenta|||Litoria gracilenta (Dainty green tree frog)	N/A	Bacillus cereus ( MIC = 50 ug/ml), Leuconostoc lactis ( MIC = 3 ug/ml), Listeria innocua ( MIC = 12 ug/ml), Micrococcus luteus ( MIC = 25 ug/ml), Staphylococcus aureus Strain ATCC 25923 ( MIC = 12 ug/ml), Staphylococcus aureus Strain ATCC 29213 ( MIC = 12 ug/ml), Staphylococcus epidermidis ( MIC = 12 ug/ml), Streptococcus uberis ( MIC = 25 ug/ml), Pasteurella multocida ( MIC = 50 ug/ml)|||No hemolysis information or data found in the reference(s) presented in this entry	Toxicon. 2006 May;47(6):664-75|||Toxicon. 2006 May;47(6):664-75|||16554081|||Toxicon. 2006 May;47(6):664-75|||Peptides. 2015 Sep;71:296-303.Toxicon. 2006 May;47(6):664-675.	25	
FPDB00098	AP01672|||AP01627|||AP01672|||RC-101	" 
GICRCICGKGICRCICGR"	Anti-Gram+||Antiviral||Anti-HIV||Anti-MRSA||Anti-toxin||Antibiofilm||inhibit S. aureus USA300||viruses HIV-1||SARS-Cov-2||influenza.||Antibacterial	amino acid substitution, mammal theta-defensin analog, animal-derived, natural derivative|||amino acid substitution, mammal theta-defensin analog, animal-derived, natural derivative|||Synthetic construct	Bridge	N/A	"RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. PubMed.|||2004 Nov;20(11):1157-65. doi: 10.1089/aid.2004.20.1157.||Lamers et al., 2011|||AIDS Res Hum Retroviruses.2004 Nov;20(11):1157-65. doi: 10.1089/aid.2004.20.1157.||Lamers et al., 2011|||AIDS Res Hum Retroviruses
. 2004 Nov;20(11):1157-65. doi: 10.1089/aid.2004.20.1157.|||AIDS Res Hum Retroviruses
. 2004 Nov;20(11):1157-65. doi: 10.1089/aid.2004.20.1157.|||16790431"	18	
FPDB00099	AP01978|||AP01978|||BmKn2|||CAMPSQ14088|||CAMPSQ14139|||CAMPSQ14397	" 
FIGAIARLLSKIF"	"Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-MRSA||Hemolytic||Antibiofilm||Wound healing||Anticancer
Crucial residues:||Anticancer||Anti-Gram+ bacteria S. aureus AB94004 or ATCC 25923 or MRSA P1386, activity value is MIC = 0.6 ug/ml||Anti-M. luteus AB93113, activity value is MIC = 8 ug/ml||Anti-B. subtilis AB91021, activity value is MIC = 5 ug/ml||Anti-B. thuringiensis AB92037, activity value is MIC = 12.5 ug/ml||Anti-S. epidermidis, activity value is MIC = 2.5||Anti-E. faecalis, activity value is MIC = 10 ug/ml||Anti-E. faecium, activity value is MIC = 10 ug/ml||Anti-E. coli, activity value is MIC = 1.5 ug/ml||Anti-P. aeruginosa AB93066 and 5 more strains, activity value is MIC = 21.3||Anti-S.aureus, activity value is MIC = 0.6 ug/ml||Anti-M.luteus, activity value is MIC = 8 ug/ml||Anti-B.subtilis, activity value is MIC = 5 ug/ml||Anti-E.coli, activity value is MIC = 1.5 ug/ml||Anti-P.aeruginosa, activity value is MIC = 21.3 ug/ml||Anti-Staphylococcus aureus AB94004, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 6.25 ug/ml||Anti-Bacillus subtilis AB91021, activity value is MIC = 12.5 ug/ml||Anti-Bacillus thuringiensis AB92037, activity value is MIC = 12.5 ug/ml||Anti-Micrococcus luteus AB93113, activity value is MIC = 6.25 ug/ml||Anti-Pseudomonas aeruginosa AB93066, activity value is MIC = 50 ug/ml||Anti-S. aureus ATCC29213, activity value is MIC = 10 ug/ml||M. abscessus ATCC19977 (MIC= >400 ug/ml)"	venom, Buthus martensii Karsch|||venom, Buthus martensii Karsch|||venom, Buthus martensii Karsch, China, Asia|||Mesobuthus martensii [Manchurian scorpion]|||Mesobuthus martensii|||Synthetic construct	Helix	venom, Buthus martensii Karsch|||Human RBCs (< 40% percent hemolysis at 100 ug/ml)	"Peptides. 2004 Feb;25(2):143-50.PubMed|||Peptides. 2004 Feb;25(2):143-50.doi: 10.1016/j.peptides.2003.12.003.||Arpornsuwan et al., 2014||Mangmee et al. 2021|||Peptides
. 2004 Feb;25(2):143-50. doi: 10.1016/j.peptides.2003.12.003.|||Peptides. 2004 Feb;25(2):143-50. doi: 10.1016/j.peptides.2003.12.003.||Arpornsuwan et al., 2014||Mangmee et al. 2021|||15062994|||22792229|||34335511|||34361810|||34780520"	13	
FPDB00100	AP02010|||AP02010|||Caerin 1.20|||DRAMP30311|||AP02010|||DRAMP30311	GLFGILGSVAKHVLPHVIPVVAEHL	Anti-Gram+||Antiviral||Anti-HIV||Anti-B. cereus, activity value is MIC = 100 ug/ml||Anti-E.faecalis, activity value is MIC > 100 ug/ml||Anti-L. lactis, activity value is MIC = 25 uM||Anti-L. innocua, activity value is MIC = 25 ug/ml||Anti-M. luteus, activity value is MIC = 20 ug/ml||Anti-or 29213, activity value is MIC = 25||Anti-S. epidermidis, activity value is MIC = 25 ug/ml||Anti-S. uberis, activity value is MIC = 50 ug/ml||Anti-E.clocae, activity value is MIC > 100 ug/ml||Anti-E.coli, activity value is MIC > 100 ug/ml||Anti-and P.multocida, activity value is MIC > 100 ug/ml||Antibacterial||Anti-Human immunodeficiency virus : inhibition of HIV Pseudovirus infection in CD4+ T cells, activity value is IC50 = 7 uM	the skin secretions, hybrid between female Litoria splendida and male Litoria caerulea , Australia|||Hybrid between female Litoria splendida and male Litoria caerulea|||Litoria caerulea/Litoria splendida|||the skin secretions, hybrid between female Litoria splendida and male Litoria caerulea , Australia|||Litoria caerulea/Litoria splendida	N/A	the skin secretions, hybrid between female Litoria splendida and male Litoria caerulea , Australia||At a concentration of 400 μM, the hemolysis rate is < 10%.	FEBS J. 2006 Aug;273(15):3511-9.PubMed|||FEBS J. 2006 Aug;273(15):3511-9.doi: 10.1111/j.1742-4658.2006.05358.x. Epub 2006 Jul 5.|||FEBS J. 2006 Aug;273(15):3511-9. doi: 10.1111/j.1742-4658.2006.05358.x. Epub 2006 Jul 5.|||16824041|||Ref.26026377|||FEBS J. 2006 Aug;273(15):3511-9.PubMed|||Peptides. 2015 Sep;71:296-303.Antibiotics (Basel). 2020 Sep 30;9(10):661.||Ref.26026377	25	
FPDB00102	AP02075|||AP02075|||CCL20|||DRAMP03555	" 
SNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM"	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Anti-HIV||Chemotactic||Antibiofilm||Anti-Gram- P. aeruginosa PA01, activity value is LD50 = 1.1 ug/ml||Anti-M. catarrhalis ATCC43627, activity value is LD50 = 0.9 ug/ml||Anti-S. pyogenes ATCC14289, activity value is LD50 = 0.2 ug/ml||Anti-E. faecium 1438, activity value is LD50 = 4.5 ug/ml||Anti-C. albicans 90028, activity value is LD50 = 25 ug/ml||Anti-and C. neoforman 96-1043, activity value is LD50 = 80 ug/ml||Anti-S. coag. neg. spp, activity value is MIC = 1.58 uM||Anti-Propionibacterium spp, activity value is MIC = 5.23 uM||Anti-S. aureus, activity value is MIC = 5.54 uM||Anti-and C. albicans, activity value is MIC = 0.09 uM||Antibacterial ; Escherichia coli ATCC25922||Staphylococcus aureus ATCC29213||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-	Skin, Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)	Combine Helix and Beta structure	Skin, Homo sapiens||At a concentration of 20 μM, the hemolysis rate is < 10%.	"J Leukoc Biol. 2003 Sep;74(3):448-55. Pub-Med. GenBank:NP_001123518.1.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.||Ramamourthy et al., 2019|||https://pubmed.ncbi.nlm.nih.gov/12949249|||J Leukoc Biol
. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||J Biol Chem. 2002 Oct 4;277(40):37647-54."	69	
FPDB00103	AP02082|||AP02082|||CXCL12	KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK	Anti-Gram+ & Gram-||Anti-HIV||Chemotactic||At 10 ug/ml||it killed 86% E. coli and 59% S. aureus.The CXCR4 chemokine receptor is excluisvely activated by CXCL12. This activation promotes chemotaxis in leukocytes||stem cells||and central nervous systems. CXCR4 is also involved in cancer metastasis and HIV replication (co-receptor for infection).||Antibacterial ; Escherichia coli ATCC25922||Staphylococcus aureus ATCC29213	Homo sapiens|||Homo sapiens [Human]	Combine Helix and Beta structure	Homo sapiens	J Leukoc Biol. 2003 Sep;74(3):448-55. Pub-Med. GenBank:O62657.1.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||https://pubmed.ncbi.nlm.nih.gov/12949249	68	
FPDB00104	AP02084|||AP02084|||XCL1	VGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG	Anti-Gram+ & Gram-||Anti-HIV||Chemotactic||At 10 ug/ml||it killed 100% E. coli and 47% S. aureus. Importantly||this CD8+ T cells derived chemokine inhibits a broad spectrum of HIV isolates.||Antibacterial ; Escherichia coli ATCC25922||Staphylococcus aureus ATCC29213	CD8+ T cells, Homo sapiens|||Homo sapiens [Human]	Beta	CD8+ T cells, Homo sapiens||At a concentration of 10 μM, the hemolysis rate is < 5%.	J Leukoc Biol. 2003 Sep;74(3):448-55. Pub-Med. GenBank:NP_002986.1|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||J Leukoc Biol. 2003 Sep;74(3):448-55. doi: 10.1189/jlb.0103024.|||12949249	93	
FPDB00110	AP02526|||DRAMP18204|||AP02526|||DRAMP18204	" 
SNASVWECCSTGSWVPFTCC"	Antiviral||Anti-HIV||Anti-It inhibited HIV-1, activity value is IC50 = 1.7 uM||Anti-HIV-2, activity value is IC50 = 1.9 uM||Anti-HSV-1, activity value is IC50 = 0.6 uM||Anti-HSV-2, activity value is IC50 = 0.3 uM||Anti-including dengue virus DENV-2, activity value is IC50 = 0.55 uM||activity value is IC50 = 0.51||Anti-West Nile virus (WNV, activity value is IC50 = 0.2 uM||Anti-hepatitis C virus (HCV, activity value is IC50 = 1.1 uM||activity value is IC50 = 2.2 uM||Antimicrobial||Anti-HSV	Actinomadura namibiensis DSM 6313	N/A	No hemolysis information or data found in the reference(s) presented in this entry	PLoS One. 2013 May 28;8(5):e64010. PubMed|||PLoS One. 2013 May 28;8(5):e64010. doi: 10.1371/journal.pone.0064010. Print 2013.|||PLoS One. 2013 May 28;8(5):e64010.|||PLoS One. 2013 May 28;8(5):e64010. PubMed|||PLoS One. 2013 May 28;8(5):e64010.	20	
FPDB00111	AP03795|||1528|||1534|||1540|||AP03795|||Ll-37|||DRAMP03075|||DRAMP03575	" 
FKRIVQRIKDFLR"	Anti-Gram+ & Gram-||Antiviral||Antiparasitic||Anti-HIV||Synergistic AMPs||LC50=60 uM||LC50=57 uM||LC50=55 uM||Anti-E. coli KCTC 1682, activity value is MIC = 16 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 32 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 16 uM||Anti-B. subtilis KCTC 3068, activity value is MIC = 4 uM||Anti-S. epidermidis KCTC 1917, activity value is MIC = 16 uM||Anti-and S. aureus KCTC1621, activity value is MIC = 16 uM||Anti-E. coli K12, activity value is MIC = 40 uM||Anti-Escherichia coli K12, activity value is MIC = 40 uM||Anti-Drug-sensitive KB cancer cells . Gram-positive bacteria: Staphylococcus aureus ATCC 29213, activity value is MIC = 16 uM||Anti-S. faecalis ATCC 29212, activity value is MIC = 32 uM||Anti-Bacillus subtilis CMCC 63501, activity value is MIC = 16 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 8 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 16 uM||Anti-Escherichia coli UB 1005, activity value is MIC = 16 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 16 uM||Anti-Salmonella typhimurium ATCC 14028, activity value is MIC = 32 uM||Anti-Salmonella typhimurium ATCC 7731, activity value is MIC = 16 uM||Anti-Escherichia coli, activity value is MIC = 5 uM||Anti-Drug-sensitive KB cancer cells .## Gram-positive bacteria: Staphylococcus aureus ATCC 29213, activity value is MIC = 16 uM||Anti-##Gram-negative bacteria: Escherichia coli ATCC 25922, activity value is MIC = 16 uM||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 5 uM	NMR-discovered, Sequence truncation; TOCSY-trim, human cathelicidin analog, animal-derived, natural derivative|||NMR-discovered, Sequence truncation; TOCSY-trim, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Homo sapiens|||Homo sapiens	Helix||Alpha helix##Random coil	No hemolytic activity (0% hemolysis at 100 µM)|||human RBC: HC50 > 256 uM, not hemo.lytic.|||[Ref.28161291] HC50>256 uM against human red blood cells. [Ref.23894079] MHC10=160 uM against human red blood cells	J Am Chem Soc. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875, PubMed|||J Am Chem Soc. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875,||Rajasekaran et al., 2017|||J Am Chem Soc. 2006 May 3;128(17):5776-85. doi: 10.1021/ja0584875, PubMed||Rajasekaran et al., 2017|||16637646|||Ref.16637646||Ref.28178190||Ref.23894079|||J Am Chem Soc. 2006 May 3;128(17):5776-5785.##Int J Mol Sci. 2017 Feb 6;18(2). pii: E339. ##Biochim Biophys Acta Biomembr. 2017 May;1859(5):722-733.##ChemMedChem. 2013 Oct;8(10):1638-42.||Ref.16637646||Ref.28178190||Ref.23894079	13	L
FPDB00112	AP03807|||AP03807|||GI-20|||DRAMP31340|||AP03807|||DRAMP31340	" 
GIKEFKRIVQRIKDFLRNLV"	Anti-Gram+ & Gram-||Antiviral||Spermicidal||Anti-HIV||Anti-It inhibits HIV-1. Active against E. faecium V284-17, activity value is MIC = 2 uM||Anti-S. aureus USA300, activity value is MIC = 2||Anti-K-pneumoniae E406-17, activity value is MIC > 32 uM||Anti-P-aeruginosa E411-17, activity value is MIC > 32 uM||Anti-and E. coli E423-17, activity value is MIC = 32 uM||Anti-MRSA||Antibiofilm||Anti-E. faecium V284-17, activity value is MIC = 2 uM||Anti-A. baumannii B28-16, activity value is MIC = 8 uM||Anti-E. coli E423-17, activity value is MIC = 32 uM||Antimicrobial	Derivative of LL-37; Sequence truncation. human cathelicidin analog, animal-derived, natural derivative|||Derivative of LL-37; Sequence truncation. human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from human cathelicidin LL-37)|||Derivative of LL-37; Sequence truncation. human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from human cathelicidin LL-37)	Helix	No hemolytic activity (0% hemolysis at 100 µM)|||human RBC: HC50 ~150 uM, some hemolytic.|||Human RBC (62% hemolysis at 200 uM)	"Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.||Zhang et al., 2021|||Antimicrob Agents Chemother
. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. Epub 2008 Jun 30.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed||Zhang et al., 2021|||34959645|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40."	20	
FPDB00113	AP03814|||Tat	" 
YGRKKRRQRRRD"	Anti-Gram+||Antiviral||Anti-HIV||active against MRSA demonstrated in human HeLa cells in vitro. D-form is more effective due to resistance to proteases (D>L). A similar sequence TAT(48-57) (seq: GRKKRRQRRR) inhibits HIV-1  .||Antifungal	designed, man-made sequences|||Synthetic construct	N/A	"Human erythrocytes (0% Hemolysis at 25 uM|||The document mentions Tat (47-58) and its enantiomer's hemolytic-related data, specifically as follows:

- L-Tat (47-58): At concentrations ranging from 1.25-20 µM, it shows no hemolytic activity against human red blood cells (RBCs), with a hemolysis rate of 0%.

- D-Tat (47-58): Within the same concentration range (1.25-20 µM), it also shows no hemolytic activity against human red blood cells, with a hemolysis rate of 0%.

- Control (Melittin, bee venom peptide): Used as a positive control, with a hemolysis rate of 100% at 20 µM, 95.4% at 10 µM, 61.1% at 5 µM, 34.5% at 2.5 µM, and 0% at 1.25 µM.

Note: In the hemolysis assay, the PBS-treated group was used as the 0% hemolysis control, and the 0.1% Triton X-100-treated group was used as the 100% hemolysis control. Hemolysis rates were calculated by measuring the absorbance at 414 nm."	J Microbiol Biotechnol. 2008 May;18(5):990-6. PubMed|||J Microbiol Biotechnol. 2008 May;18(5):990-6.||Keogan et al., 2012|||J Microbiol Biotechnol. 2008 May;18(5):990-6. PubMed||Keogan et al., 2012|||16678135	12	
FPDB00114	AP03839|||DRAMP31336|||AP03839|||LL-37|||DRAMP31336	" 
SKEKIGKEFKRIVQRIKDFLR"	Antiviral||Anti-HIV||Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 10.8 uM||Antimicrobial||Antiviral ; HIV[IC50 REP = 10.8 uM]	Sequence truncation, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from human cathelicidin LL-37)|||Sequence truncation, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from human cathelicidin LL-37)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% cell death at 22.5 uM	Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||18591279|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.	21	
FPDB00115	AP03840|||DRAMP31342|||AP03840|||LL-37|||DRAMP31342	GIKEWKRIVQRIKDFLRNLV	Antiviral||Anti-HIV||Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 7.4 uM||Antimicrobial||Antiviral ; HIV[IC50 REP = 7.4 uM]	Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from human cathelicidin LL-37)|||Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from human cathelicidin LL-37)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% cell death at 23.6 uM	Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||18591279|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.	20	
FPDB00116	AP05207|||DRAMP31354|||AP05207|||Apelin-12|||DRAMP31354	RPRLSHKGPMPF	Anti-HIV-1 infection, activity value is IC50 = 63 ug/ml||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV[IC50 E = 63 ug/ml]	sequence truncation, mammals, animal-derived, natural derivatives|||Synthetic construct|||sequence truncation, mammals, animal-derived, natural derivatives|||Synthetic construct	N/A	N/A	"Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. 2000
FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3.|||FEBS Lett. 2000 May 4;473(1):15-8.|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||https://pubmed.ncbi.nlm.nih.gov/10802050|||FEBS Lett. 2000 May 4;473(1):15-8."	12	
FPDB00117	AP05206|||DRAMP31355|||AP05206|||Apelin-13|||DRAMP31355	QRPRLSHKGPMPF	Anti-HIV-1 infection, activity value is IC50 = 26 ug/ml||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV[IC50 E = 26 ug/ml]	sequence truncation, mammals, animal-derived, natural derivatives|||Bos taurus (Bovine)|||sequence truncation, mammals, animal-derived, natural derivatives|||Bos taurus|||Bos taurus (Bovine)	N/A	N/A	"Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. 2000
 FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3.|||FEBS Lett. 2000 May 4;473(1):15-8.|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||https://pubmed.ncbi.nlm.nih.gov/10802050|||FEBS Lett. 2000 May 4;473(1):15-8."	13	
FPDB00118	AP05205|||DRAMP31356|||AP05205|||Apelin-17|||DRAMP31356	KFRRQRPRLSHKGPMPF	Anti-HIV-1 infection, activity value is IC50 = 4.8 ug/ml||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV[IC50 E = 4.8 ug/ml]	sequence truncation, mammals, animal-derived, natural derivatives|||Synthetic construct|||sequence truncation, mammals, animal-derived, natural derivatives|||Synthetic construct	N/A	N/A	"Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. 2000
: FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3.|||FEBS Lett. 2000 May 4;473(1):15-8.|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||https://pubmed.ncbi.nlm.nih.gov/10802050|||FEBS Lett. 2000 May 4;473(1):15-8."	17	
FPDB00119	AP05204|||DRAMP31357|||AP05204|||DRAMP31357	LVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF	Anti-HIV-1 infection, activity value is IC50 = 0.3 ug/ml||Antimicrobial||Antiviral||Anti-HIV	sequence truncation, mammals, animal-derived, natural derivatives|||Bos taurus (Bovine)|||sequence truncation, mammals, animal-derived, natural derivatives|||Bos taurus (Bovine)	N/A	N/A	"Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. 2000
 FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3.|||J Virol. 2000 Dec;74(24):11972-6.|||FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3. PubMed|||J Virol. 2000 Dec;74(24):11972-6."	36	
FPDB00120	AP05191	PKGPTYSWDEAKNPGGPNRCSNSKQCDGARTCSSSGFCQGTAGHAAA	Anti-HIV-1, activity value is EC50 = 0.182 uM||Antiviral||Anti-HIV	amino acid substitution, sequence truncation, bacteria-derived, natural derivatives	N/A	N/A	"Xiong C, O'Keefe BR, Byrd RA, McMahon JB.2006
 Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018.|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed"	47	
FPDB00121	AP05190	GSGPTYSWNEANNPGGPNRCSNNKQCDGARTCSSSGFCQG	Anti-HIV-1, activity value is EC50 = 0.0345 uM||Antiviral||Anti-HIV	amino acid substitution, sequence truncation, bacteria-derived, natural derivatives	N/A	N/A	"Xiong C, O'Keefe BR, Byrd RA, McMahon JB.2006
 Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018.|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed"	40	
FPDB00122	AP05189	GSGPTYSWNEANNPGGPNRCSNNKQCDGARTCSSSGFCQGTSRKPDPG	Anti-HIV-1, activity value is EC50 = 0.0076 uM||Antiviral||Anti-HIV	amino acid substitution, sequence truncation, bacteria-derived, natural derivatives	N/A	N/A	"Xiong C, O'Keefe BR, Byrd RA, McMahon JB.2006
 Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018.|||Peptides. 2006 Jul;27(7):1668-75. doi: 10.1016/j.peptides.2006.03.018. PubMed"	48	
FPDB00123	AP04543|||Kn2-7|||CAMPSQ14095|||DRAMP18558	FIKRIARLLRKIF	Anti-Gram- E. coli AB94012 or ATCC 25922, activity value is MIC = 6.25||Anti-P. aeruginosa AB93066 or A092994 like 5 strains, activity value is MIC = 25||Anti-S. aureus AB94004 or ATCC 25923 or MRSA, activity value is MIC = 3.13 ug/ml||Anti-S. epidermidis, activity value is MIC = 2.5||Anti-E. faecalis, activity value is MIC = 5||Anti-E. faecium, activity value is MIC = 5 ug/ml||Anti-B. subtilis AB91021, activity value is MIC = 6.25 ug/ml||Anti-B. thuringiensis AB92037, activity value is MIC = 6.25 ug/ml||Anti-and M. luteus AB93113, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus AB94004, activity value is MIC = 3.13 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.13 ug/ml||Anti-Bacillus subtilis AB91021, activity value is MIC = 6.25 ug/ml||Anti-Bacillus thuringiensis AB92037, activity value is MIC = 6.25 ug/ml||Anti-Micrococcus luteus AB93113, activity value is MIC = 6.25 ug/ml||Anti-Escherichia coli AB94012, activity value is MIC = 6.25 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa AB93066, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa A092994, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa A093052, activity value is MIC = 100 ug/ml||Anti-Pseudomonas aeruginosa A093056, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa A093085, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa A093115, activity value is MIC = 100 ug/ml||Anti-S. aureus P1383, activity value is MIC = 6.25 ug/ml||Anti-Penicillin-resistant S. epidermidis P1389, activity value is MIC = 6.25 ug/ml||Anti-Methicillin resistant S. aureus P1381, activity value is MIC = 6.25 ug/ml||Anti-Methicillin resistant S. aureus P1386, activity value is MIC = 6.25 ug/ml||Anti-Methicillin resistant S. aureus P1374, activity value is MIC = 3.13 ug/ml||Anti-Methicillin resistant coagulase-negative Staphylococcus P1369, activity value is MIC = 3.13 ug/ml||Anti-Penicillin-sensitive S. epidermidis P1111, activity value is MIC = 3.13 ug/ml||Anti-S. aureus ATCC29213, activity value is MIC = 5 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 10 ug/ml||Anti-##Gram-negative bacteria: Escherichia coli AB94012, activity value is MIC = 6.25 ug/ml	amino acid substitution, animal-derived, natural derivative|||Synthetic construct	Helix||Alpha helix	"The peptide Kn2-7 had little hemolytic activity at high
concentration (Figure 1D). According to the method of Ka¨ ber
modified by Achmarine, the HC50 values of the mutant peptide
Kn2-7 and the wild-type peptide BmKn2 were 90270 ug/ml and
17130 ug/ml, respectively (Figure 1D). Therefore, the hemolytic
activity of Kn2-7 was significantly decreased, compared to the
wild-type peptide BmKn2.|||No hemolytic activity (0% hemolysis at 100 µM)|||Kn2-7 peptide: HC₅₀ value is 90.27 µg/ml. BmKn2 peptide (wild-type peptide): HC₅₀ value is 17.13 µg/ml.|||Kn2-7: 50% hemolytic concentration (HC₅₀) is 90.27 µg/ml; 
Wild-type peptide BmKn2: 50% hemolytic concentration (HC₅₀) is 17.13 µg/ml; 
(Note: Determined by human red blood cell hemolysis assay, positive control 0.1% Triton X-100 is 100% hemolysis, 0.85% physiological saline is 0% hemolysis).|||Human RBCs (> 90% percent hemolysis at 100 ug/ml)|||[Ref.22792229]Non-hemolysis at 6.25 ug/ml, 5% hemolysis at 12.5 ug/ml,10% hemolysis at 25 ug/ml 15% hemolysis at 50 ug/ml, 40% hemolysis at 100 ug/ml against human red blood cells"	"Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z, Li W.2012
 PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135. PubMed|||PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135.|||2012;7(7):e40135. doi: 10.1371/journal.pone.0040135. Epub 2012 Jul 5.|||. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135. Epub 2012 Jul 5.|||22792229|||34335511|||PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135.||Ref.22792229"	13	
FPDB00124	AP03863	CRLGRLLRRLGRCLLR	Anti-E. coli, activity value is MIC = 60 uM||Anti-B. subtilis, activity value is MIC = 60 uM||Antiviral||Anti-HIV	De novo designed, man-made sequences	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	16	
FPDB00125	AP03862	GCRRLCGRLGRRLCRLLCR	Anti-HSV-2MS in Vero cells, activity value is EC50 = 69.3 ug/ml||Anti-HSV-2MS in Vero cells, activity value is EC50 = 64.7 ug/ml||Anti-B.subtilis, activity value is MIC > 120 uM||Antiviral||Anti-HIV	De novo designed, man-made sequences	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	19	
FPDB00126	AP03861	GLRRLCGRLGRRLCRLLLR	Anti-HSV-2MS in Vero cells, activity value is EC50 = 6.37 ug/ml||Anti-HSV-2MS in Vero cells, activity value is EC50 = 15 ug/ml||Anti-B.subtilis, activity value is MIC > 120 uM||Antiviral||Anti-HIV	De novo designed, man-made sequences	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	19	
FPDB00127	AP03860	GLRCRLGRLLRRLGRCLLR	Anti-HSV-2MS in Vero cells, activity value is EC50 = 1.81 ug/ml||Anti-HSV-2MS in Vero cells, activity value is EC50 = 5.43 ug/ml||Anti-B.subtilis, activity value is MIC > 120 uM||Antiviral||Anti-HIV	De novo designed, man-made sequences	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	19	
FPDB00128	AP03859	GCRRLLGRLLRRLGRLLCR	Anti-HSV-2MS in Vero cells, activity value is EC50 = 30 ug/ml||Anti-B.subtilis, activity value is MIC > 120 uM||Antiviral||Anti-HIV	De novo designed, man-made sequences	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	19	
FPDB00129	AP03858	GSRRPVPIIYCNRRTGRCQRI	Anti-Human Immunodeficiency Virus Type 1 HIV-1IIIB, activity value is EC50 = 3.33 ug/ml||Antiviral||Anti-HIV	amino acid substitution, insects, animal-derived, natural derivative	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	21	
FPDB00130	AP03857	GSKKPVPIIYCNRRTGKCQRI	Anti-Human Immunodeficiency Virus Type 1 HIV-1IIIB, activity value is EC50 = 13.1 ug/ml||Anti-HSV-2MS in Vero cells, activity value is EC50 = 2320000 ug/ml||Antiviral||Anti-HIV	Amino acid substitution, insects, animal-derived, natural derivatives	N/A	"No hemolytic activity (0% hemolysis at 100 µM)|||The document mentions hemolytic-related data of the V series antimicrobial peptides, as follows:

- V1: Hemolytic activity EC_{50} against human red blood cells is 880.0 μM.

- V2: Hemolytic activity EC_{50} against human red blood cells is 589.0 μM.

- V3: Hemolytic activity EC_{50} against human red blood cells is 590.0 μM.

- V4: Hemolytic activity EC_{50} against human red blood cells is 3,226.0 μM.

- V5: Hemolytic activity EC_{50} against human red blood cells is 1,055.0 μM.

- V6: Hemolytic activity EC_{50} against human red blood cells is 35.0 μM.

- V7: Hemolytic activity EC_{50} against human red blood cells is 45.0 μM.

Note: EC_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; a higher value indicates lower hemolytic activity. In the experiment, the peptide concentration ranged from 0.01 to 375 μg/ml, and hemolysis was assessed by measuring the hemoglobin released from human red blood cells."	"Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2011
 J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003.|||J AIDS Clinic Res S2:003. doi:10.4172/2155-6113.S2-003. Wang HIV screen project"	21	
FPDB00131	AP03856|||DRAMP30306|||AP03856|||DRAMP30306	GLRRLLGRLLRRLGRLLLR	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 4.4 uM||Anti-HSV-2MS in Vero cells, activity value is EC50 = 2.32 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 4.4 uM||Antiviral||Anti-HIV	Amino acid substitution, de novo designed, man-made sequences|||Synthetic construct|||Amino acid substitution, de novo designed, man-made sequences|||Synthetic construct	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	19	
FPDB00132	AP03855|||DRAMP30305|||AP03855|||DRAMP30305	GLRSRIWLWVLLMIWQESNRFKRM	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 1.25 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 1.25 uM||Antiviral||Anti-HIV	Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct(derived from Dermaseptin S9)|||Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct(derived from Dermaseptin S9)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	24	
FPDB00133	AP03854|||DRAMP30303|||AP03854|||DRAMP30303	ILGPVLGLVSRTLRRVLGIL	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 2.2 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 2.2 uM||Antiviral||Anti-HIV	Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct(derived from Maximin H5)|||Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct(derived from Maximin H5)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	20	
FPDB00134	AP03853|||DRAMP30302|||AP03853|||DRAMP30302	GWLKKIESIIDAF	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 29.5 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 29.5 uM||Antiviral||Anti-HIV	template-based designed, man-made sequences|||Synthetic construct(derived from Cecropin)|||template-based designed, man-made sequences|||Synthetic construct(derived from Cecropin)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	13	
FPDB00135	AP03852|||DRAMP30301|||AP03852|||DRAMP30301	GFLDIIEKIAKSW	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 10.5 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 10.5 uM||Antiviral||Anti-HIV	template-based designed, man-made sequences|||Synthetic construct(derived from Ranatuerin 3)|||template-based designed, man-made sequences|||Synthetic construct(derived from Ranatuerin 3)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	13	
FPDB00136	AP03851|||DRAMP30300|||AP03851|||DRAMP30300	GIWSDLAEIIKKF	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 11.4 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 11.4 uM||Antiviral||Anti-HIV	template-based designed, man-made sequences|||Synthetic construct(derived from Ponericin W3)|||template-based designed, man-made sequences|||Synthetic construct(derived from Ponericin W3)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	13	
FPDB00137	AP03850|||DRAMP30298|||AP03850|||DRAMP30298	GWFDIIKKIASEL	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 10.7 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 10.7 uM||Antiviral||Anti-HIV	template-based designed, man-made sequences|||Synthetic construct(derived from Uperin 7.1)|||template-based designed, man-made sequences|||Synthetic construct(derived from Uperin 7.1)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	13	
FPDB00138	AP03849|||DRAMP30297|||AP03849|||DRAMP30297	GIIDIAKKLFESW	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 20.1 uM||Anti-HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells, activity value is EC50 = 20.1 uM||Antiviral||Anti-HIV	template-based designed, man-made sequences|||Synthetic construct(derived from Uperin 2.7)|||template-based designed, man-made sequences|||Synthetic construct(derived from Uperin 2.7)	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Ref.20086159|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.||Ref.20086159"	13	
FPDB00139	AP03848	GLFDIIKKIAESW	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 11.7 uM||Antiviral||Anti-HIV	amino acid substitution, amphibians, animal-derived, natural derivative	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed"	13	
FPDB00140	AP03847|||AP03847|||Temporin-LTc-3r	SLSRFLRFLKIVYRRAF	Anti-S. aureus USA300 MRSA, activity value is MIC = 12.5 uM||Anti-Gram+ & Gram-||Antiviral||Anti-HIV||Anti-MRSA||Anti-S. aureus, activity value is MIC = 12.5 uM||Anti-E. coli, activity value is MIC = 25 uM	Amino acid substitution, amphibians, animal-derived, natural derivative|||Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Antimicrob Agents Chemother
. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. Epub 2010 Jan 19.|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||22445495|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed"	17	
FPDB00141	AP03846|||AP03846|||DASamP1|||DRAMP04317	FFGKVLKLIRKIF	Anti-S. aureus USA300 MRSA, activity value is MIC = 3.1 uM||Anti-Gram+||Antiviral||Anti-HIV||Anti-MRSA||Anti-Bacillus subtilis, activity value is MIC > 100 uM||Anti-Pseudomonas aeruginosa, activity value is MIC > 100 uM||Anti-S. aureus, activity value is MIC = 3.1 uM||Anti-E. coli, activity value is MIC > 100 uM||Antimicrobial||Antibacterial	Amino acid substitution, amphibians, animal-derived, natural derivative|||FFGKVLKLIRKIF|||Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||hemolytic HC50 25 uM.|||Human RBC (HL50 = 25 uM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed||Menousek et al., 2012|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.||Menousek et al., 2012|||Antimicrob Agents Chemother
. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. Epub 2010 Jan 19.|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed||Menousek et al., 2012|||22445495|||Int J Antimicrob Agents. 2012 May;39(5):402-406.|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed"	13	
FPDB00142	AP03845|||Uperin 7.1KRF	GWFDVVKHIAKRF	Anti-S. aureus USA300 MRSA, activity value is MIC = 50 uM||Antiviral||Anti-HIV||Anti-MRSA||Anti-S. aureus, activity value is MIC = 50 uM||Anti-E. coli, activity value is MIC = 12.5 uM	Amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct	N/A	No hemolytic activity (0% hemolysis at 100 µM)	"Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. 2010
 Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09.|||Antimicrob Agents Chemother
. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. Epub 2010 Jan 19.|||22445495|||Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. doi: 10.1128/AAC.01448-09. PubMed"	13	
FPDB00143	AP03844|||DRAMP31346|||AP03844|||Cathelicidin-6|||DRAMP31346	GRFKRFRKPFKKLFKKIS	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 3.2 uM||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV[IC50 REP = 3.2 uM]	Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from BMAP-27)|||Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from BMAP-27)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% cell death at 18.9 uM	"Wang G, Watson KM, Buckheit RW Jr. 2008
 Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||https://pubmed.ncbi.nlm.nih.gov/18591279|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40."	18	
FPDB00144	AP03843|||DRAMP31345|||AP03843|||BMAP-18|||DRAMP31345	GRFKRFRKKFKKLFKKIS	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 0.35 uM||Anti-HSV-2MS in Vero cells, activity value is EC50 = 27.2 uM||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV-1[IC50 REP = 0.35 uM]	Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from BMAP-27)|||Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from BMAP-27)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% cell death at 8.45 uM	"Wang G, Watson KM, Buckheit RW Jr. 2008
 Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||https://pubmed.ncbi.nlm.nih.gov/18591279|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40."	18	
FPDB00888	AP00499	VGAlAvVvWlWlWlW	Anti-Gram+ B. subtilis ATCC 663, activity value is MIC = 2.5 uM||Anti-S. aureus ATCC 6538, activity value is MIC = 2.5 uM||Anti-S. pyogenes ATCC 1961, activity value is MIC = 0.16 uM||Anti-S. hemolyticus group A type 6, activity value is MBC = 2 ug/ml||Anti-and S. aureus, activity value is MBC = 10 ug/ml	soil bacterium, Bacillus brevis	Helix	N/A	J Exp Med. 1939 Aug 31;70(3):249-56. doi: 10.1084/jem.70.3.249.||Wang et al., 2012	15	
FPDB00889	AP02034	EQCREEEDDRB	Anti-Disk diffusion assay: only fraction SU2 showed antifungal activity. It inhibited mycelial growth in M. arachidicola, activity value is IC50 = 1.2 uM||Antiviral||Antifungal||Anti-HIV	Cocos nucifera	N/A	N/A	"Peptides. 2005 Dec;26(12):2392-6. doi: 10.1016/j.peptides.2005.05.009.|||Peptides
. 2005 Dec;26(12):2392-6. doi: 10.1016/j.peptides.2005.05.009.|||Peptides. 2005 Dec;26(12):2392-6. PubMed"	11	
FPDB00890	AP02095|||AP02095|||SLPI	SGKSFKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPVKA	Likely kills S. aureus and E. coli. Active against metabolically active fungi A. fumigatus and C. albicans but not metabolically quiescent forms. Antifungal activity is localized to the N-terminal region  ). It seems that the N-terminal domain is responsible for antimicrobial activity. It also inhibits neutrophil elastase and other enzymes via its C-terminal domain||especially Leu72-Met73 residues. It also inhibts HIV-1 and HIV-2. It may constitute a major shield from HIV infection orally (Stergios Doumas et al.||2005).||Antibacterial||Antifungal||Antiviral ; E. coli||P. aeruginosa||S. aureus||S. epidermis||group A Streptococcus||A. fumigatus||C. albicans||HIV	tears, saliva, airway, gastrointestines, genital tracts, Homo sapiens|||Homo sapiens [Human]	Beta	tears, saliva, airway, gastrointestines, genital tracts, Homo sapiens	"J Bacteriol. 1989 Apr;171(4):2166-72. doi: 10.1128/jb.171.4.2166-2172.1989.||Tomee JF et al., 1997|||J Bacteriol. 1989 Apr;171(4):2166-72. doi: 10.1128/jb.171.4.2166-2172.1989.||Tomee JF et al., 1997|||16336202|||J Bacteriol
. 1989 Apr;171(4):2166-72. doi: 10.1128/jb.171.4.2166-2172.1989.||Tomee JF et al., 1997"	107	
FPDB00891	AP02130|||DRAMP00261	GSGPTYCWNEANNPGGPNRCSNNKQCDGARTCSSSGFCQGTSRKPDPGPKGPTYCWDEAKNPGGPNRCSNSKQCDGARTCSSSGFCQGTAGHAAA	inhibited HIV-1||Ebola virus.||Antimicrobial||Antiviral	cyanobacterium, Scytonema varium|||Scytonema varium (cyanobacterium)	Combine Helix and Beta structure||Combine helix and strand structure	No hemolysis information or data found in the reference(s) presented in this entry	Biochemistry. 2003 Mar 11;42(9):2578-84.doi: 10.1021/bi0205698.|||Biochemistry. 2003 Mar 11;42(9):2578-2584.Peptides. 2006 Jul;27(7):1668-1675.Protein Sci. 2007 Dec;16(12):2756-2760.	95	
FPDB00892	AP02131|||DRAMP00262	LGKFSQTCYNSAIQGSVLTSTCERTNGGYNTSSIDLNSVIENVDGSLKWQPSNFIETCRNTQLAGSSELAAECKTRAQQFVSTKINLDDHIANIDGTLKYE	It binds multiple mannose-rich glycans on HIV-1 gp120  .||Antimicrobial||Antiviral	cyanobacterium (blue-green alga), Nostoc ellipsosporum|||Nostoc ellipsosporum (cyanobacterium)	Beta||Combine helix and strand structure	No hemolysis information or data found in the reference(s) presented in this entry	Antimicrob Agents Chemother. 1997 Jul;41(7):1521-30.doi: 10.1128/AAC.41.7.1521.||Alexandre KB et al., 2013|||Antimicrob Agents Chemother. 1997 Jul;41(7):1521-1530.Nat Struct Biol. 1998 Jul;5(7):571-578.	101	
FPDB00893	AP02132	ASYKVNIPAGPLWSNAEAQQVGPKIAAAHQGNFTGQWTTVVESAMSVVEVELQVENTGIHEFKTDVLAGPLWSNDEAQKLGPQIAASYGAEFTGQWRTIVEGVMSVIQIKYTF	antiviral.	freshwater cyanobacteria, blue-green algae, Microcystis viridis NIES-102	Combine Helix and Beta structure	N/A	Biochem Biophys Res Commun. 1999 Nov 30;265(3):703-8.doi: 10.1128/AAC.41.7.1521.	113	
FPDB00894	AP02133	SLTHRKFGGSGGSPFSGLSSIAVRSGSYLDAIIIDGVHHGGSGGNLSPTFTFGSGEYISNMTIRSGDYIDNISFETNMGRRFGPYGGSGGSANTLSNVKVIQINGSAGDYLDSLDIYYEQY	It binds multiple mannose-rich glycans on HIV-1 gp120  . You can rotate||zoom||and view the 3D structure here in the PDB.	the red alga Griffithsia sp	Beta	N/A	J Biol Chem. 2005 Mar 11;280(10):9345-53.doi: 10.1074/jbc.M411122200. Epub 2004 Dec 21.||Alexandre KB et al., 2013	121	
FPDB00895	AP03841|||DRAMP31343|||AP03841|||LL-37|||DRAMP31343	GIKQFKRIVQRIKDFLRNLV	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 0.91 uM||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV[IC50 REP = 0.91 uM]	Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from human cathelicidin LL-37)|||Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct(derived from human cathelicidin LL-37)	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% cell death at 13.7 uM	Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||18591279|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.	20	
FPDB00896	AP03842|||DRAMP31344|||AP03842|||LL-37|||DRAMP31344	GIKEFKREFQRIKDFLRNLV	Anti-Human Immunodeficiency Virus Type 1 HIV-1, activity value is EC50 = 0.91 uM||Antimicrobial||Antiviral||Anti-HIV||Antiviral ; HIV[IC50 REP = 1.6 uM]	Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct(derived from human cathelicidin LL-37)|||Amino acid substitution, cathelicidin analog, animal-derived, natural derivative|||Synthetic construct	N/A	No hemolytic activity (0% hemolysis at 100 µM)|||CEM-SS cells (50% cell death at 9.9 uM	Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. PubMed|||18591279|||Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.	20