Unique_ID	Origin_ID	Sequence	Activity	Source	Structure	Hemolysis	Reference	Length	Stereo
FPDB00002	AP00026|||AP00026|||Lactotransferrin precursor|||LFcinB|||DRAMP02840	FKCRRWQWRMKKLGAPSITCVRRAF	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||anti-sepsis||Synergistic AMPs||Anticancer||Anti-E. coli IID-861, activity value is MIC = 2 uM||Anti-K. pneumoniae JCM1662T, activity value is MIC = 3 uM||Anti-P. aeruginosa IFO-3446, activity value is MIC = 3 uM||Anti-S. aureus JCM-2151 or MRSA, activity value is MIC = 2 uM||Anti-L. monocytogenes IDF-1 b, activity value is MIC = 0.3 uM||MRSA||Antibacterial||Anti-Streptomyces scabiei S58, activity value is IC50 = 1.222||Anti-Escherichia coli L361, activity value is MIC = 4 uM||Anti-Salmonella Salford, activity value is MIC = 4 uM||Anti-Escherichia coli O:9, activity value is MIC = 6 uM||Anti-Pseudomonas fluorescens, activity value is MIC = 10 uM||Anti-Listeria monocytogenes, activity value is MIC = 2 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Bacillus cereus, activity value is MIC = 6 uM||Anti-ctive against E. coli IID-861, activity value is MIC = 2 uM	cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||cattle, Bos taurus|||Bos taurus [Bovine]|||Bos taurus (Bovine)	Beta||Beta strand (4 strands; 8 residues)	E.coli ( MIC = 12.5 ug/ml)	"J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.|||Bellamy W, Takase M, Wakabayashi H, Kawase K, Tomita M.1992
 J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol. 1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol. 1992 Dec;73(6):472-9. PubMed.|||1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012||Sengupta J et al., 2012|||J Appl Bacteriol
. 1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.|||9521752 , 8980754|||35213576|||Ref.8980754|||1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.||Ke T et al., 2012"	25	
FPDB00010	AP00146|||1841|||1993|||2145|||2297|||2450|||2593|||2736|||3337|||3338|||3339|||3340|||3791|||3797|||3803|||3809|||3815|||AP00146|||Melittin|||DRAMP03002|||AP00146|||Melittin	GIGAVLKVLTTGLPALISWIKRKRQQ	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Insecticidal||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Anti-E. coli W 160-37, activity value is MIC = 5||Anti-S. aureus 8530B, activity value is MIC = 10||Anti-B. subtilis, activity value is MIC = 2||Anti-and P. putida NCIM 2102, activity value is MIC = 25||Anti-and E. agglomerans Bo-1S . ActivityG: D=L. Also active against colistin-resistant A. baumannii. C. albicans, activity value is MIC = 3||Anti-HSV-2 . It is also insecticidal, activity value is EC50 = 5.9||Anti-S. aureus, activity value is MIC = 4.4 uM||Anti-and E. faecium, activity value is MIC = 2.2 uM||Anti-P. aeruginosa, activity value is MIC = 2.2 uM||Anti-and V. vulnificus, activity value is MIC = 4.4 uM||Anti-T. beigelii, activity value is MIC = 4.4 uM||Anti-M. furfur, activity value is MIC = 8.8 uM||activity value is LD50 = 9 ug/ml||activity value is LD50 = 23 ug/ml||activity value is LD50 = 18 ug/ml||activity value is LD50 = 25 ug/ml||activity value is LD50 = 13 ug/ml||activity value is LD50 = 35 ug/ml||activity value is IC50 = 3.2||activity value is IC50 = 2.1||activity value is IC50 = 1.8||activity value is IC50 = 1.4||Anti-and E. agglomerans Bo-1S . ActivityG: D=L. Also active against colistin-resistant A. baumannii. Active against Gram+ bacteria S. mutants, activity value is MIC = 1.1 uM||Anti-S. aureus 29213 or 25923, activity value is MIC = 2 uM||Anti-L.rhamnosus 1.0385 or 1.0911, activity value is MIC > 128 uM||Anti-L.plantarum 7469, activity value is MIC > 128 uM||Anti-S.thermophilus YM-C, activity value is MIC > 128 uM||Anti-C. tropicalis cgmcc 2.1975, activity value is MIC = 2 uM||Anti-and C. parapsilosis cgmcc 2.3989, activity value is MIC = 2 uM||Anti-SARS CoV2, activity value is EC50 = 0.656 ug||Anti-E. coli 25922, activity value is MIC = 1 uM||Anti-E. coli UB1005, activity value is MIC = 1 uM||Anti-E. coli K88, activity value is MIC = 1 uM||Anti-E. coli K99, activity value is MIC = 1 uM||Anti-E. coli 078, activity value is MIC = 2 uM||Anti-E. coli 987P, activity value is MIC = 1 uM||Anti-P. aeruginosa 27853, activity value is MIC = 2 uM||Anti-P. aeruginosa PAO1, activity value is MIC = 2 uM||Anti-S. typhimurium 14028, activity value is MIC = 2 uM||Anti-S. typhimurium 7731, activity value is MIC = 2 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 2 uM||Anti-Listeria monocytogenes CMCC 54004, activity value is MIC = 1 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1 uM||Anti-Escherichia coli UB 1005, activity value is MIC = 2 uM||Anti-Salmonella pullorum C7913, activity value is MIC = 8 uM||Anti-Salmonella enterica subsp enterica CMCC 50071, activity value is MIC = 2 uM||Enzyme inhibitor	Honeybee venom, Apis mellifera (also A. florea, A. cerana)|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Honeybee venom, Apis mellifera (also A. florea, A. cerana)|||Apis mellifera [Honeybee]|||Apis mellifera (Honeybee)|||Honeybee venom, Apis mellifera (also A. florea, A. cerana ), Europe|||Apis mellifera [Honeybee]	Helix||Alpha helix	"Since these amphiphilic peptides may be membrane dis ruptive
(12), magainin 2 was assayed for hemolytic activityagainst human erythrocytes (Fig. 4B). Unlike mellitin, ahemolytic, amphiphilic 26-amino acid peptide from beevenom (12), magainin 2 was not hemolytic up to at least 0.00015 ug/ml in phosphate-buffered normal saline (Fig. 4B). Theabsence of hemolytic activity of magainin 2 is striking in thatit possesses a potential hydrophobic moment very similar tomellitin (12)|||Moderate hemolytic activity (50% hemolysis at 50 µM)|||Under physiological salt concentration, when melittin at concentrations up to 500 µg was incubated with 1×10⁹/ml human red blood cells at 37°C for 3 hours, no significant hemolytic activity was observed (<0.5%); however, in 10,000 µM sodium phosphate buffer containing 340,000 µM sucrose, high concentrations of melittin exhibited significant hemolytic activity, although the exact values were not specified.|||​|||sheep red blood cells (11000 uM)|||In Document 11 (Gene 2018), the recombinant hybrid antimicrobial peptide AL32-P113 and the synthetic hybrid peptide L31-P113 both exhibited hemolytic activity against human erythrocytes. At a concentration of 500 μg/ml, the hemolysis rate of AL32-P113 was 10.4% ± 2.2%, and that of L31-P113 was 12.0% ± 0.7%; as controls, the hemolysis rate of LL-37 was 2.9% ± 0.7%, and that of Hst-5 was 1.6% ± 0.6%.|||Moderate hemolytic activity (50% hemolysis at 50 µM)|||sheep red blood cells (11000 uM)|||It is highly hemolytic (100% at 6.25 uM) and can cause histamine release (85% at 10 uM) (Kawakami et al., 2017)."	"Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med.|||Fennell JF, Shipman WH, Cole LJ.1967
 Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med.||ref AP252||Ref. AP83||ref, see AP2411||see ref. AP1480||Yasin et al., 2000||Perez-Cordero JJ et al. 2011 Peptides 32, 683-90|||Res Dev Tech Rep. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638|||. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638||Yasin et al., 2000|||Res Dev Tech Rep
. 1967 Dec 5:1-13. doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||ref, see AP2411||see ref. AP1480||Yasin et al., 2000||Perez-Cordero JJ et al. 2011 Peptides 32, 683-90|||9568968, 35236909|||31199117|||Eur J Biochem. 1983 Sep 1;135(1):123-126.||Ref.29783753|||Res Dev Tech Rep. 1967 Dec 5:1-13.doi: 10.21236/ad0658324.||ref AP252||Ref. AP83||see ref. AP1480||for ref, see AP5638|||9568968, 35236909|||Res Dev Tech Rep. 1967 Dec 5:1-13.Pub-Med."	26	L
FPDB00013	AP00160|||AP00160|||DS4|||DRAMP18708|||AP00160|||DRAMP18708	ALWMTLLKKVLKAAAKAALNAVLVGANA	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||anti-sepsis||Antimalarial||Hemolytic||Anti-A. caviae IP67-16T, activity value is MIC = 0.5 uM||Anti-E. coli IP76-24, activity value is MIC = 4 uM||Anti-S. aureus IP76-25, activity value is MIC = 10||Anti-N. brasiliensis IP118079, activity value is MIC = 10 uM||Anti-S. cerevisiae IP118079, activity value is MIC = 20 uM||Anti-IP886-65, activity value is MIC = 20 uM||Anti-C. neoformans IP960-67 and IP962-67, activity value is MIC = 1||Anti-M. canis IP1194, activity value is MIC = 15 uM||Anti-T. rubrum IP2043-92, activity value is MIC = 40 uM||Anti-T. metagrophytes IP877-71, activity value is MIC = 20 uM||Anti-mutant, activity value is MIC = 30 uM||Anti-A. simii J43, activity value is MIC = 20 uM||Anti-A. niger IP218-53 and A. fumigatus IP1025-70, activity value is MIC = 20||Anti-C. albicans, activity value is MIC = 11.5||Anti-S1, activity value is MIC = 295.97 ug/ml||Anti-S2, activity value is MIC = 380.82 ug/ml||Anti-S3, activity value is MIC = 343.68 ug/ml||Anti-S4, activity value is MIC = 358.13 ug/ml||Anti-S5, activity value is MIC = 274.17 ug/ml||Anti-S6, activity value is MIC = 330.65 ug/ml||Anti-S7, activity value is MIC = 411.06 ug/ml||Anti-S1, activity value is MIC = 250.22 ug/ml||Anti-S2, activity value is MIC = 269.06 ug/ml||Anti-S3, activity value is MIC = 490.77 ug/ml||Anti-S4, activity value is MIC = 257.4 ug/ml||Anti-S5, activity value is MIC = 308.89 ug/ml||Anti-S6, activity value is MIC = 344.32 ug/ml||Anti-S7, activity value is MIC = 275.73 ug/ml||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||[Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria||fungi||protozoa||and the enveloped herpes simplex virus type 1	Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa hypochondrialis [orange-legged leaf frog]|||Synthetic construct|||Phyllomedusa sauvagei (Sauvage's leaf frog)|||Sauvage's leaf frog, Phyllomedusa sauvagii, South America|||Phyllomedusa sauvagei (Sauvage's leaf frog)	Helix||Alpha helix	No hemolytic activity (0% hemolysis at 200 μM)|||Dermaseptin S1: At a concentration of 70 µM, treatment for 1 hour did not cause hemolysis of human red blood cells. Dermaseptin S2: At 70 µM, hemolysis of red blood cells occurred within 1 hour. Dermaseptin S3: At 80 µM, hemolysis of red blood cells occurred within 1 hour. Dermaseptin S4: At 1 µM, 100% hemolysis occurred within 1 hour; at 0.5 µM, 50% hemolysis was observed. Dermaseptin S5: At a concentration of 90 µM, treatment for 1 hour did not cause hemolysis of human red blood cells.|||hRBCs, >50% hemolysis at 8 ug/ml|||hRBCs, >50% hemolysis at 128 ug/ml|||[Swiss_Prot Entry P80280]Strong hemolytic activity	"J Biol Chem. 1994;269(50):31635-31641.PubMed.|||J Biol Chem. 1994;269(50):31635-31641.|||1994 Dec 16;269(50):31635-41.|||J Biol Chem
. 1994 Dec 16;269(50):31635-41.|||33774792|||Eur. J. Biochem. 1994; 219:145-154.|||J Biol Chem. 1994;269(50):31635-31641.|||Eur. J. Biochem. 1994; 219:145-154."	28	
FPDB00014	AP00176|||AP00176|||Human defensin 1|||DRAMP03591|||AP00176|||DRAMP03591|||AP00176|||DRAMP03591	ACYCRIPACIAGERRYGTCIYQGRLWAFCC	Chemotactic||Anti-MRSA||Anti-toxin||Enzyme inhibitor||anti-sepsis||Wound healing||Anticancer||Anti-Killed C. difficile. Active against L. monocytogenes, activity value is MIC = 39.7 ug/ml||Anti-S.epidermis, activity value is MIC = 2.2 ug/ml||Anti-S. aureus or MRSA, activity value is MIC = 5.2||Anti-and S. maltophilia, activity value is MIC = 1.8||Anti-Gram+ & Gram-||Antiviral||Antifungal||Antiparasitic||Anti-HIV||T. cruzi||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)	neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens [Human]|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens (Human)|||neutrophils; natural killer cells, monocytes; airway, saliva; Homo sapiens|||Homo sapiens (Human)	Beta||Beta strand	Strong hemolytic activity (100% hemolysis at 5 μM)|||No hemolysis information or data found in the reference(s) presented in this entry	"J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI1985
 J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||Comparative Study J Clin Invest
. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||17635867|||Viruses. 2021 Jun 26;13(7):1246.|||J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||Viruses. 2021 Jun 26;13(7):1246.Proteomics. 2009 Mar;9(5):1364-1373.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.|||1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.||Peschel et al., 2001||Buck et al., 2006||Xu et al., 2021||Li et al., 2020||Charp et al., 1988|||Viruses. 2021 Jun 26;13(7):1246."	30	
FPDB00018	AP00195|||1426|||AP00195|||IB-200|||IB-445|||OLAP-311|||Protegrin-1|||Recombinant Protegrin-1|||PG-1|||Protegrin|||IB-247	RGGRLCYCRRRFCVCVGR	"Anti-Gram+||Antiviral||Antifungal||candidacidal||Anti-HIV||Anti-MRSA||anti-sepsis||Synergistic AMPs||Hemolytic||Antibiofilm||61% Cytotoxicity at 0.5 ug/ml||Anti-E. coli 004, activity value is MIC = 0.12 ug/ml||Anti-V, activity value is MIC = 0.25 ug/ml||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 0.5 ug/ml||Anti-S. aureus ATCC 33591 or MRSA, activity value is MIC = 2 ug/ml||Anti-MRSA, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 2 ug/ml||MIC E.Coli (ATCC 25922: 2 ug/ml||ATCC 700926: 0.25 ug/ml||MB 4902: 0.015 ug/ml)||K. pneumoniae (ATCC 13883: 0.5 ug/ml||ATCC 700603: 4 ug/ml||BAA 2146: 4 ug/ml)||A. baumannii (ATCC 19606): 0.25 ug/ml||P. aeruginosa (ATCC 27853): 4 ug/ml||B. subtilis (ATCC 6051): 0.03 ug/ml||S. aureus ATCC 43300 (MRSA): 4 ug/ml||C. albicans (ATCC 90028): 2 ug/ml||C. neoformans (ATCC 208821): 0.06 ug/ml||Anti-E. coli, activity value is MIC = 64 ug/ml||Anti-S. aureus, activity value is MIC = 64 ug/ml||Anti-S. epiderrnidis, activity value is MIC = 2 ug/ml||Anti-Escherichia coli ATCC 25377, activity value is MIC = 3 ug/ml||Anti-A. baumannii ATCC 238719, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 361823, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 371484, activity value is MIC = 2 ug/ml||Anti-A. baumannii ATCC 371981, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 378177, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 378648, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 379385, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 379622, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 380023, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 380667, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 381577, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 382933, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 383074, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 383290, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 386052, activity value is MIC = 4 ug/ml||Anti-A. baumannii ATCC 388538, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 5615, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 12316, activity value is MIC = 8 ug/ml||Anti-A. baumannii ATCC 12834, activity value is MIC = 4 ug/ml||Anti-S. aureus 29213, activity value is MIC = 1.7 ug/ml||Anti-E. coli 25922, activity value is MIC = 0.75 ug/ml||Anti-P. aeruginosa 27853, activity value is MIC = 0.5 ug/ml||Anti-E. faecalis 29212, activity value is MIC = 2.7 ug/ml||Anti-""A. baumannii ATCC 238719, activity value is MIC = 4 ug/ml||Antibacterial||Anti-K. pneumoniae strains NTUH-K2044, activity value is MIC = 0.5 ug/ml||Anti-ATCC 43816, activity value is MIC = 0.5 ug/ml||Anti-ATCC 13883, activity value is MIC = 0.5 ug/ml||Anti-ATCC 700603, activity value is MIC = 0.5 ug/ml||Anti-MKP103, activity value is MIC = 2 ug/ml||Anti-MKP103 wza mutant, activity value is MIC = 1 ug/ml||Anti-P. aeruginosa, activity value is MIC = 0.5 ug/ml"	leukocytes; porcine neutrophil, pig, Sus scrofa|||eukocytes; porcine neutrophil, pig, Sus scrofa|||leukocytes; porcine neutrophil, pig, Sus scrofa|||Synthetic construct|||Porcine neutrophils|||Sus scrofa [pig]	Beta	96.1% hemolysis at 64 uM (see ref. AP05000).	Chem Pharm Bull (Tokyo). 1995 May;43(5):853-8|||Chem Pharm Bull (Tokyo). 1995 May;43(5):853-8||Blower et al., 2018||Yasin et al., 2000||Guo C et al., 2014||Sousa et al., 2017|||Blower et al., 2018||Yasin et al., 2000||Guo C et al., 2014||Sousa et al., 2017|||8647100|||31399625|||31214759|||28382709, 9257752, 31214759||Refer 31214759|||34502403|||35254120|||10931444	18	L
FPDB00019	AP00211|||AP00211|||OLAP-313|||Polyphemusin-1|||L-Polyphemusin|||DRAMP02933|||Polyphemusin-1|||AP00211	RRWCFRVCYRGFCYRKCR	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-HIV||anti-sepsis||Anti-Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1 ug/ml||Anti-E. coli K12, activity value is MIC = 6.3 ug/ml||Anti-S. Minnesota 1114W or R595, activity value is MIC = 3.1||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 6.3 ug/ml||Anti-and C. albicans M9, activity value is MIC = 6.3 ug/ml||MIC E.Coli (ATCC 25922: 0.5 ug/ml||ATCC 700926: 0.06 ug/ml||MB 4902: 0.03 ug/ml)||K. pneumoniae (ATCC 13883: 0.5 ug/ml||ATCC 700603: 1 ug/ml||BAA 2146: 2 ug/ml)||A. baumannii (ATCC 19606): 0.06 ug/ml||P. aeruginosa (ATCC 27853): 2 ug/ml||B. subtilis (ATCC 6051): 0.25 ug/ml||S. aureus ATCC 43300 (MRSA): 2 ug/ml||C. albicans (ATCC 90028): 1 ug/ml||C. neoformans (ATCC 208821): 0.06 ug/ml||Antibacterial||Anti-S.aureus, activity value is MIC = 16 ug/ml||Anti-Escherichia coli UB1005, activity value is MIC = 0.5 ug/ml||Anti-E. coli DC2, activity value is MIC = 1 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 0.25 ug/ml||Anti-S. typhimurium, activity value is MIC = 1 ug/ml||Anti-Pseudomonas aeruginosa K799, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa Z61, activity value is MIC = 1 ug/ml||Anti-Staphylococcus aureus SAP0017, activity value is MIC = 2 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 1 ug/ml||Anti-Enterococcus faecalis, activity value is MIC = 1 ug/ml||Antifungal ; Candida albicans M9||Anti-Active against Gram- S. typhimurium LT2 and 1102, activity value is MIC = 3.1 ug/ml	Limulus polyphemus|||Limulus polyphemus|||Limulus polyphemus [Atlantic horseshoe crab]|||Synthetic construct|||Limulus polyphemus (Atlantic horseshoe crab)|||Limulus polyphemus	Beta||No secondary structure (CD)	Moderate hemolytic activity (40% hemolysis at 20 μM)|||IC50 for hRBC = 1885 ug/ml	"J. Biochem. 1989; 106: 663-668. PubMed|||J. Biochem. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||J Biochem
. 1989 Oct;106(4):663-8. doi: 10.1093/oxfordjournals.jbchem.a122913.|||2514185|||28453851|||Biochim Biophys Acta. 2004 May 6;1698(2):239-250.|||2514185|||J. Biochem. 1989; 106: 663-668. doi: 10.1093/oxfordjournals.jbchem.a122913."	18	
FPDB00021	AP00214|||AP00214|||OLAP-314|||Tachyplesin-1|||TAC1_CARRO Tachyplesin-1|||TP I|||AP00214|||DRAMP02926	KWCFRVCYRGICYRRCR	Anti-Gram+ & Gram-||Antiviral||Anti-HIV||anti-sepsis||Hemolytic||Anticancer||Anti-Gram- S. typhimurium LT2 or 1102, activity value is MIC = 0.8||Anti-E. coli K12, activity value is MIC = 1.6||Anti-S. Minnesota 1114W or R595, activity value is MIC = 1.6||Anti-P. aeruginosa, activity value is MIC = 12.5 ug/ml||Anti-S. aureus 209P or ATCC 25923, activity value is MIC = 3.1||Anti-B. subtilis, activity value is MIC = 3.1 ug/ml||Anti-C. albicans M9, activity value is MIC = 3.1 ug/ml||Anti-and C. neoformans IMF 40040, activity value is MIC = 1.56 ug/ml||MIC E.Coli (ATCC 25922: 0.06 ug/ml||ATCC 700926: 0.03 ug/ml||MB 4902: 0.016 ug/ml)||K. pneumoniae (ATCC 13883: 0.125 ug/ml||ATCC 700603: 0.25 ug/ml||BAA 2146: 0.25 ug/ml)||A. baumannii (ATCC 19606): 0.125 ug/ml||P. aeruginosa (ATCC 27853): 0.25 ug/ml||B. subtilis (ATCC 6051): 0.125 ug/ml||S. aureus ATCC 43300 (MRSA): 1 ug/ml||C. albicans (ATCC 90028): 4 ug/ml||C. neoformans (ATCC 208821): 0.125 ug/ml||Anti-28960954: E.coli ATCC25922, activity value is MIC = 0.06 ug/ml||Anti-K. pneumoniae ATCC13883, activity value is MIC = 0.06 ug/ml||Anti-A. baumannii ATCC 700603, activity value is MIC = 0.25 ug/ml||Anti-A. baumannii BAA, activity value is MIC = 0.25 ug/ml||Anti-PmxR, activity value is MIC = 2 ug/ml||Anti-A. baumannii ATCC19606, activity value is MIC = 0.06 ug/ml||Anti-PmxR, activity value is MIC = 0.125 ug/ml||Anti-P.aeuroginsa ATCC 27853, activity value is MIC = 0.125 ug/ml||Anti-P.aeuroginsa FADDI-FAO70, activity value is MIC = 0.25 ug/ml||Anti-B.subtilis ATCC6051, activity value is MIC = 0.06 ug/ml||Anti-S.aureus ATCC43300, activity value is MIC = 0.25 ug/ml||Anti-C.albicans ATCC90028, activity value is MIC = 2 ug/ml||Anti-C.neoformanas ATCC208821, activity value is MIC = 0.125 ug/ml||Anti-31455019 : Escherichia coli ATCC 25922, activity value is MIC = 0.5||Anti-Escherichia coli DC2 CGSC 7139, activity value is MIC = 0.0625||Anti-S. aureus ATCC 25923, activity value is MIC = 1||Anti-S. aureus ATCC 6538, activity value is MIC = 4||Anti-Escherichia coli ML-35p, activity value is MIC = 0.062 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 0.5 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 0.5 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 8 uM||Anti-Staphylococcus aureus 209P, activity value is MIC = 0.5 uM||Anti-B. subtilis B-886, activity value is MIC = 0.5 uM||Anti-M. luteus B-1314, activity value is MIC = 1 uM||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Anti-cancer	hemocytes, Southeast Asia, Tachypleus tridentatus; Tachypleus gigas; Carcinoscorpius rotundicauda|||hemocytes, Southeast Asia, Tachypleus tridentatus; Tachypleus gigas; Carcinoscorpius rotundicauda|||Tachypleus tridentatus|||Tachypleus gigas|||Carcinoscorpius rotundicauda|||Limulus polyphemus [Atlantic horseshoe crab]|||hemocytes, Southeast Asia, Tachypleus tridentatus; Tachypleus gigas; Carcinoscorpius rotundicauda|||Tachypleus tridentatus (Japanese horseshoe crab)	Beta||Beta strand	Weak hemolytic activity (15% hemolysis at 20 μM)|||hRBC (38% hemolysis at 100 uM)|||[Ref.29870123] 9.6% hemolytic activity at 8 ug/ml and 72.8% hemolytic activity at 512 ug/ml against human red blood cells.	"J Biol Chem. 1988 Nov 15;263(32):16709-13.PubMed.|||Nakamura T, Furunaka H, Miyata T, Tokunaga F, Muta T, Iwanaga S, Niwa M, Takao T, Shimonishi Y.1988
 J Biol Chem. 1988 Nov 15;263(32):16709-13.PubMed.||Peschel et al., 2001|||J Biol Chem. 1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||J Biol Chem
. 1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||3141410, 28960954, 31455019|||2229025|||30486233|||1988 Nov 15;263(32):16709-13.||Peschel et al., 2001|||Biochemistry 2002; 41: 12359.J Biochem. 1990 Aug;108(2):261-266.  Int J Mol Sci. 2019 Aug 26;20(17):4184."	17	
FPDB00036	AP00310|||AP00310|||LL-37|||LL-37|||AP00310	LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES	Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antiparasitic||Spermicidal||Anti-HIV||Chemotactic||Anti-MRSA||Enzyme inhibitor||anti-TB||anti-sepsis||Synergistic AMPs||Hemolytic||Antibiofilm||Wound healing||Anticancer||Anti-L. monocytogenes EGD, activity value is MIC = 1.5 ug/ml||Antibacterial||Anti-S. aureusNCTC 6571, activity value is MIC = 19.3||Anti-E. coli ATCC 25922, activity value is MIC = 9.8||Anti-27367675: E.coli K88, activity value is MIC = 61||Anti-E.coli CVCC245, activity value is MIC = 61||Anti-S.aureus CVCC 26003, activity value is MIC = 36||Anti-S.aureus ATCC 25923, activity value is MIC = 58||Anti-Listeria monocytogene CVCC 1599, activity value is MIC = 13||Anti-Micrococcus luteus CVCC 28001, activity value is MIC = 90||Anti-A. baumannii ATCC 19606, activity value is MIC = 4 ug/ml||Anti-29022391 : S. mutans, activity value is MIC = 250 ug/ml||Anti-A. israelii, activity value is MIC = 7.81 ug/ml||Anti-E. faecalis, activity value is MIC = 2000 ug/ml||Anti-31417238: Streptococcus agalactiae NEM 316, activity value is MIC = 90||Anti-C-terminal:COOH): A. baumannii 6043, activity value is MIC = 14.2 uM||Anti-P. aeruginosa ATCC 19660, activity value is MIC = 28.5 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 28.5 uM||Anti-28649410: P. aeruginosa ATCC 9027, activity value is EC50 = 0.525 uM||Anti-P. aeruginosa PAO1 (pTDKGFP, activity value is EC50 = 0.599 uM||Anti-F. novicida U112, activity value is EC50 = 0.0534 uM||Anti-B. thailandensis E264, activity value is EC50 = 1.88 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 0.552 uM||Anti-31016971: Staphylococcus aureus SA113 WT, activity value is MIC = 256 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 256 uM	gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes|||Homo sapiens|||Homo sapiens [Human]|||Homo sapiens [Human]|||gammadelta T cells, neutrophils, monocytes; macrophages; mast cells; lymphocytes, Mesenchymal Stem Cells; islets; sweat/skin; airway/lung, saliva; colonic mucosa; bone marrow and testis, Homo sapiens; Also Pan troglodytes	Helix	Moderate hemolytic activity (60% hemolysis at 50 μM)|||hRBC (4.47 (±0.35)% hemolysis at 175 ug/ml), Sheep RBC (HC₅₀=32 ± 0.68 ug/ml)|||hRBC (4.47 (±0.35)% hemolysis at 175 ug/ml), Sheep RBC = (HC50=32 ± 0.68 ug/ml)	"Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R. T.1996
 Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed|||1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||Eur J Biochem
. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x.|||28476579|||28408902, 30076860, 28400226, 27367675, 30076864, 30043322, 29022391, 31417238, 31396193, 31016971|||35254120|||28408902, 30076860, 28400226, 27367675, 30076864, 30043322, 29022391, 31417238, 31396193, 31016971||Refer 30076860||Refer PubMed ID: 30076864||Refer PubMed ID: 30043322|||Eur J Biochem. 1996 Jun 1;238(2):325-32. doi: 10.1111/j.1432-1033.1996.0325z.x. PubMed"	37	
FPDB00123	AP04543|||Kn2-7|||CAMPSQ14095|||DRAMP18558	FIKRIARLLRKIF	Anti-Gram- E. coli AB94012 or ATCC 25922, activity value is MIC = 6.25||Anti-P. aeruginosa AB93066 or A092994 like 5 strains, activity value is MIC = 25||Anti-S. aureus AB94004 or ATCC 25923 or MRSA, activity value is MIC = 3.13 ug/ml||Anti-S. epidermidis, activity value is MIC = 2.5||Anti-E. faecalis, activity value is MIC = 5||Anti-E. faecium, activity value is MIC = 5 ug/ml||Anti-B. subtilis AB91021, activity value is MIC = 6.25 ug/ml||Anti-B. thuringiensis AB92037, activity value is MIC = 6.25 ug/ml||Anti-and M. luteus AB93113, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus AB94004, activity value is MIC = 3.13 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 3.13 ug/ml||Anti-Bacillus subtilis AB91021, activity value is MIC = 6.25 ug/ml||Anti-Bacillus thuringiensis AB92037, activity value is MIC = 6.25 ug/ml||Anti-Micrococcus luteus AB93113, activity value is MIC = 6.25 ug/ml||Anti-Escherichia coli AB94012, activity value is MIC = 6.25 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa AB93066, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa A092994, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa A093052, activity value is MIC = 100 ug/ml||Anti-Pseudomonas aeruginosa A093056, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa A093085, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa A093115, activity value is MIC = 100 ug/ml||Anti-S. aureus P1383, activity value is MIC = 6.25 ug/ml||Anti-Penicillin-resistant S. epidermidis P1389, activity value is MIC = 6.25 ug/ml||Anti-Methicillin resistant S. aureus P1381, activity value is MIC = 6.25 ug/ml||Anti-Methicillin resistant S. aureus P1386, activity value is MIC = 6.25 ug/ml||Anti-Methicillin resistant S. aureus P1374, activity value is MIC = 3.13 ug/ml||Anti-Methicillin resistant coagulase-negative Staphylococcus P1369, activity value is MIC = 3.13 ug/ml||Anti-Penicillin-sensitive S. epidermidis P1111, activity value is MIC = 3.13 ug/ml||Anti-S. aureus ATCC29213, activity value is MIC = 5 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 10 ug/ml||Anti-##Gram-negative bacteria: Escherichia coli AB94012, activity value is MIC = 6.25 ug/ml	amino acid substitution, animal-derived, natural derivative|||Synthetic construct	Helix||Alpha helix	"The peptide Kn2-7 had little hemolytic activity at high
concentration (Figure 1D). According to the method of Ka¨ ber
modified by Achmarine, the HC50 values of the mutant peptide
Kn2-7 and the wild-type peptide BmKn2 were 90270 ug/ml and
17130 ug/ml, respectively (Figure 1D). Therefore, the hemolytic
activity of Kn2-7 was significantly decreased, compared to the
wild-type peptide BmKn2.|||No hemolytic activity (0% hemolysis at 100 µM)|||Kn2-7 peptide: HC₅₀ value is 90.27 µg/ml. BmKn2 peptide (wild-type peptide): HC₅₀ value is 17.13 µg/ml.|||Kn2-7: 50% hemolytic concentration (HC₅₀) is 90.27 µg/ml; 
Wild-type peptide BmKn2: 50% hemolytic concentration (HC₅₀) is 17.13 µg/ml; 
(Note: Determined by human red blood cell hemolysis assay, positive control 0.1% Triton X-100 is 100% hemolysis, 0.85% physiological saline is 0% hemolysis).|||Human RBCs (> 90% percent hemolysis at 100 ug/ml)|||[Ref.22792229]Non-hemolysis at 6.25 ug/ml, 5% hemolysis at 12.5 ug/ml,10% hemolysis at 25 ug/ml 15% hemolysis at 50 ug/ml, 40% hemolysis at 100 ug/ml against human red blood cells"	"Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z, Li W.2012
 PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135. PubMed|||PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135.|||2012;7(7):e40135. doi: 10.1371/journal.pone.0040135. Epub 2012 Jul 5.|||. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135. Epub 2012 Jul 5.|||22792229|||34335511|||PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135.||Ref.22792229"	13	
FPDB00158	AP00029|||1186|||1190|||1194|||1198|||CE-MA|||DRAMP03914|||DRAMP03963	KWKLFKKIKFLHSAKKF	Antiviral||Antiparasitic||anti-sepsis||Antimalarial||Anticancer||activity value is IC50 = 85.3 uM||activity value is IC50 = 100 uM||activity value is IC50 = 65 uM||Anti-Gram- E. coli, activity value is MIC = 6.25 uM||Anti-S. typhimurium, activity value is MIC = 0.78 uM||Anti-P. aeruginosa, activity value is MIC = 1.56 uM||Anti-B. subtilis, activity value is MIC = 1.56 uM||Anti-S. pyogenes, activity value is MIC = 0.78 uM||Anti-and S. aureus, activity value is MIC = 3.12 uM||Anti-Candida albicans, activity value is MIC = 250 ug/ml||Anti-C. glabrata, activity value is MIC = 512 ug/ml||Anti-A. fumigatus, activity value is MIC > 1000 ug/ml||Anti-M. canis, activity value is MIC > 1000 ug/ml||Antimicrobial||Antifungal||Antibacterial	hybrid peptide, designed, man-made sequences|||Synthetic construct (De novo design)|||Synthetic construct	Helix	The hemolytic activity of CA-MA and its analogs on human red blood cells was tested at a concentration of 100 μM, and the results showed that the hemolysis rate of all peptides was 0% (see Table 2 for specific data).	"Oh H, Hedberg M, Wade D, Edlund C.
 Antimicrob Agents Chemother. 2000 Jan;44(1):68-72.PubMed.|||2000 Feb 15;1463(2):209-18. doi: 10.1016/s0005-2736(99)00210-2.|||33676184|||Int J Mol Sci. 2012; 13(11): 15042-15053.|||Biochemistry. 2000 Oct 3;39(39):11855-11864."	17	L
FPDB00164	AP00101|||AP00101|||Temporin-L|||Temporin B|||Temporin B|||AP00101	FVQWFSKFLGRIL	Active against B. megaterium and E. coli  . Active against parasites L. mexicana  .||Antibacterial||Anti-Klebsiella pneumoniae NCTC 13368, activity value is MIC = 16 ug/ml||Anti-Klebsiella pneumoniae M6, activity value is MIC = 16 ug/ml||Anti-Acinetobacter baumanii AYE, activity value is MIC = 4 ug/ml||Anti-Acinetobacter baumanii ATCC 17978, activity value is MIC = 4 ug/ml||Anti-Pseudomonas aeruginosa PAO1 128, activity value is MIC = 16 ug/ml||Anti-Pseudomonas aeruginosa NCTC 13437, activity value is MIC = 32||Anti-Escherichia coli NCTC 12923, activity value is MIC = 4 ug/ml||Anti-Methicillin sensitive Staphylococcus aureus ATCC 9144, activity value is MIC = 2 ug/ml||Anti-Epidemic methicillin resistant Staphylococcus aureus-15, activity value is MIC = 4 ug/ml||Anti-Epidemic methicillin resistant Staphylococcus aureus-16, activity value is MIC = 4 ug/ml||Anti-Vancomycin sensitive Enterococcus faecalis NCTC 775, activity value is MIC = 4||Anti-Vancomycin resistant Enterococcus faecalis NCTC 12201, activity value is MIC = 8 ug/ml||Anti-Candida albicans NCPF 3179, activity value is MIC = 8 ug/ml||Antifungal	European common frog, Rana temporaria|||European common frog, Rana temporaria|||Rana temporaria [european common frog]|||Rana temporaria [Frog]|||Rana temporaria [Frog]|||European common frog, Rana temporaria	Helix	"Hemolytic activity test results: Temporin A and Temporin B both showed less than 1% hemolysis of human red blood cells at a concentration of 120 μM, whereas bee venom peptide (melittin) can cause more than 90% red blood cell hemolysis at 0.9 μM.

Example data:

Temporin A: Hemolytic concentration > 120 μM.

Temporin B: Hemolytic concentration > 120 μM.

Melittin: Hemolytic concentration 0.9 μM."	"Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.1996
 Eur J Biochem. 1996 Dec 15;242(3):788-92. PubMed.||ref for AP00095||Molecules. 2015 Feb 6;20(2):2775-85|||1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||ref for AP00095||Molecules. 2015 Feb 6;20(2):2775-85|||Eur J Biochem
. 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||ref for AP00095||Molecules. 2015 Feb 6;20(2):2775-85|||9022710|||31358802|||31358802|||Eur J Biochem. 1996 Dec 15;242(3):788-92. doi: 10.1111/j.1432-1033.1996.0788r.x.||ref for AP00095||Molecules. 2015 Feb 6;20(2):2775-85"	13	
FPDB00166	AP00135|||DRAMP03077|||AP00135|||DRAMP03077	GWLKKIGKKIERVGQHTRDATIQTIGVAQQAANVAATLK	Anti-Gram+ & Gram-||Antifungal||anti-sepsis||Anticancer||Antimicrobial||Antibacterial	the Medfly, Ceratitis capitata; also housefly, Musca domestica|||Ceratitis capitata (Mediterranean fruit fly) (Musca domestica)|||the Medfly, Ceratitis capitata; also housefly, Musca domestica|||Ceratitis capitata (Mediterranean fruit fly) (Musca domestica)	Helix||Alpha helix	N/A	"Rosetto M, Manetti AGO, Marchini D, Dallai R., Telford JL.1993
 Gene 1993; 134: 241-243. PubMed.|||1993 Dec 8;134(2):241-3. doi: 10.1016/0378-1119(93)90100-h.|||Gene
. 1993 Dec 8;134(2):241-3. doi: 10.1016/0378-1119(93)90100-h.|||Gene. 1993 Dec 8;134(2):241-243.|||Gene 1993; 134: 241-243. doi: 10.1016/0378-1119(93)90100-h.|||Gene. 1993 Dec 8;134(2):241-243."	39	
FPDB00168	AP00144|||1116|||1306|||1307|||1308|||1309|||1310|||1311|||1312|||1313|||1314|||1359|||1365|||1371|||1377|||1383|||1389|||1395|||1401|||1407|||1413|||AP00144|||Magainin-2|||Magainin-2 amide|||DRAMP02271|||Magainin 2|||AP00144	GIGKFLHSAKKFGKAFVGEIMNS	Anti-E. coli D31, activity value is MIC = 5 ug/ml||Anti-S. epidermidis, activity value is MIC = 10 ug/ml||Anti-C. freundii, activity value is MIC = 30 ug/ml||Anti-S. aureus, activity value is MIC = 50 ug/ml||Anti-C. albicans, activity value is MIC = 80 ug/ml||Anti-and S. marcescens, activity value is MIC = 100 ug/ml||activity value is IC50 = 110 uM||activity value is IC50 = 32.3 uM||activity value is IC50 = 54.1 uM||activity value is IC50 = 28.6 uM||activity value is IC50 = 484 uM||activity value is IC50 = 52.4 uM||activity value is IC50 = 57.8 uM||activity value is IC50 = 135.3 uM||activity value is IC50 = 31 uM||activity value is IC50 = 59.4 uM||activity value is IC50 > 150 ug/ml||activity value is IC50 > 200 ug/ml||Antibacterial||Antifungal||Antiparasitic||Anti-Escherichia coli D31, activity value is MIC = 5 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC = 10 ug/ml||Anti-Escherichia coli, activity value is MIC = 50 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 10 ug/ml||Anti-Citrobacter freundii, activity value is MIC = 30 ug/ml||Anti-Enterobacter cloacae, activity value is MIC = 50 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 100 ug/ml||Anti-Serratia marcescens, activity value is MIC = 100 ug/ml||Anti-Proteus mirabilis, activity value is MIC > 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC = 10 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Streptococcus fecalis, activity value is MIC > 100 ug/ml||Anti-Candida albicans, activity value is MIC = 80 ug/ml||Anti-Streptococcus fecalis Paramecium caudatum, activity value is MIC = 10 ug/ml||Anti-Euglena gracilis ] [ - E.coli ATCC 25922, activity value is MIC = 62||Anti-Klebsiella Pneumonae ATCC 13883, activity value is MIC = 125||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 125||Anti-Candida ablicansATCC 14053, activity value is MIC = 250||Anti-Gram+ & Gram-||Antiviral||candidacidal||Insecticidal||Spermicidal||anti-sepsis||Antimalarial||Synergistic AMPs||Wound healing||Anticancer	skin; Stomach, African clawed frog, Xenopus laevis, Africa|||skin; Stomach, African clawed frog, Xenopus laevis, Africa|||Xenopus laevis [African clawed frog]|||Xenopus ruwenzoriensis (Uganda clawed frog)|||skin; Stomach, African clawed frog, Xenopus laevis, Africa	Helix	"Since these amphiphilic peptides may be membrane dis ruptive
(12), magainin 2 was assayed for hemolytic activityagainst human erythrocytes (Fig. 4B). Unlike mellitin, ahemolytic, amphiphilic 26-amino acid peptide from beevenom (12), magainin 2 was not hemolytic up to at least 0.00015 ug/ml in phosphate-buffered normal saline (Fig. 4B). Theabsence of hemolytic activity of magainin 2 is striking in thatit possesses a potential hydrophobic moment very similar tomellitin (12)|||​|||[ Refer PubMed : 3299384 :- Escherichia coli D31 ( MIC = 5 ug/ml), Klebsiella pneumoniae ( MIC = 10 ug/ml), Pseudomonas putida ( MIC = 10 ug/ml), Staphylococcus epidermidis ( MIC = 10 ug/ml), Citrobacter freundii ( MIC = 30 ug/ml), Enterobacter cloacae ( MIC = 50 ug/ml), Escherichia coli ( MIC = 50 ug/ml), Staphylococcus aureus ( MIC = 50 ug/ml), Candida albicans ( MIC = 80 ug/ml), Pseudomonas aeruginosa ( MIC = 100 ug/ml), Serratia marcescens ( MIC = 100 ug/ml), Proteus mirabilis ( MIC = >100 ug/ml), Streptococcus fecalis ( MIC = >100 ug/ml)Paramecium caudatum ( MIC = 10 ug/ml), Amoeba proteus , Euglena gracilis ] [ Refer PubMed : 1717472 :- E.coli ATCC 25922 ( MIC = 62-125 ug/ml), Klebsiella Pneumonae ATCC 13883 ( MIC = 125-250 ug/ml), Pseudomonas aeruginosa ATCC 27853 ( MIC = 125-250 ug/ml), Staphylococcus aureus ATCC 29213 ( MIC = >500 ug/ml), Streptococcus faecalis ATCC 29212 ( MIC = >500 ug/ml), Candida ablicansATCC 14053 ( MIC = 250-500 ug/ml) ], [ Refer Pubmed ID 35073323: Mycoplasma pneumoniae ]|||Xanthomonas axonopodis pv. glycines (MIC = 13 uM), Escherichia coli (MIC = 13 uM), Pseudomonas aeruginosa (MIC = 26 uM)|||In Document 4 (Proc. Natl. Acad. Sci. USA 1987), magainin 1 and magainin 2, isolated from the skin of the African clawed frog (Xenopus laevis), showed no hemolytic activity against human erythrocytes, and no hemolysis was observed even at concentrations up to 150 µg/ml in phosphate-buffered saline.|||Magainin 2 shows no hemolytic activity on human red blood cells even at concentrations as high as 150 µg/ml; whereas melittin, the bee venom peptide, exhibits significant hemolytic effects at low concentrations."	"Zasloff M.1987
 Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. PubMed.||Peschel et al., 2001|||1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.||see ref AP4787||Peschel et al., 2001|||Proc Natl Acad Sci U S A
. 1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.||Peschel et al., 2001|||1717472 , 3299384, 35073323|||23029273|||Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-5453.|||1717472 , 3299384, 35073323||PubMed : 3299384||PubMed : 1717472||Refer Pubmed ID 35073323|||Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.|||1987 Aug;84(15):5449-53. doi: 10.1073/pnas.84.15.5449.|||Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. PubMed."	23	L
FPDB00185	AP00308|||1420|||AP00308|||Buforin-2|||BF2|||DRAMP01163|||Buforin-2|||AP00308|||DRAMP01163	TRSSRAGLQFPVGRVHRLLRK	Anti-Gram+ bacteria B. subtilis, activity value is MIC = 2 ug/ml||Anti-S. aureus, activity value is MIC = 4 ug/ml||Anti-S. mutans, activity value is MIC = 2 ug/ml||Anti-S. pneumoniae, activity value is MIC = 4 ug/ml||Anti-P. putida, activity value is MIC = 2 ug/ml||Anti-E. coli, activity value is MIC = 4 ug/ml||Anti-S. typhimurium, activity value is MIC = 1 ug/ml||Anti-Serratia sp, activity value is MIC = 4 ug/ml||Anti-C. albicans, activity value is MIC = 1 ug/ml||Anti-C. neoformans, activity value is MIC = 1 ug/ml||Anti-and S. cerevisiae, activity value is MIC = 1 ug/ml||5% Cytotoxicity at 0.5 ug/ml||Anti-ctive against Gram+ bacteria B. subtilis, activity value is MIC = 2 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 4 ug/ml||Anti-Streptococcus mutans, activity value is MIC = 2 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 4 ug/ml||Anti-Pseudomonas putida, activity value is MIC = 2 ug/ml||Anti-Escherichia coli, activity value is MIC = 4 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 1 ug/ml||Anti-Candida albicans, activity value is MIC = 1 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC = 1 ug/ml||Antibacterial||Anti-Saccharomyces cerevisiae, activity value is MIC = 1 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||anti-sepsis||Anticancer	derivative of buforin I after treatment with endoproteinase, protease digestion|||derivative of buforin I after treatment with endoproteinase, protease digestion|||Bufo gargarizans [Asian toad]|||Sphaenorhynchus lacteus [Orinoco lime treefrog]|||Bufo gargarizans (Asian toad) (Bufo bufo gargarizans)|||derivative of buforin I after treatment with endoproteinase, Sequence truncation, animal-derived, natural derivative|||Bufo gargarizans (Asian toad) (Bufo bufo gargarizans)	Helix||Alpha helix	Human RBCs (<50% hemolysis at 6.25-200 uM)	"Park CB, Kim MS, Kim SC.1996
 Biochem. Biophys. Res. Commun. 1996; 218:408-413||Lee 2008 Cancer Lett 271: 47-51|||Biochem. Biophys. Res. Commun. 1996; 218:408-413||Lee 2008 Cancer Lett 271: 47-51|||Lee 2008 Cancer Lett 271: 47-51|||8573171|||30044391|||Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.|||8573171|||Biochem. Biophys. Res. Commun. 1996; 218:408-413||Lee 2008 Cancer Lett 271: 47-51|||Biochem. Biophys. Res. Commun. 1996; 218:408-413"	21	L
FPDB00195	AP00429|||AP00429|||Antimicrobial peptide NK-lysin|||DRAMP02980|||AP00429	GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE	Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||anti-sepsis||Antimalarial||Anticancer||Anti-Escherichia coli D21, activity value is MIC = 8 uM||Anti-Bacillus megaterium, activity value is MIC = 0.8 uM||Anti-moderate PIG Escherichia coli Bd2221/75, activity value is MIC = 39 uM||Anti-Streptococcus pyogeneis, activity value is MIC = 34 uM||Anti-Candida albicans, activity value is MIC = 31 uM||Anti-with medium E]: Escherichia coli D21, activity value is MIC = 0.5 uM||Anti-Escherichia coli Bd2221/75, activity value is MIC = 10 uM||Anti-Acinetobacter calcoaceticus Ac 11, activity value is MIC = 7 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 1.6 uM||Anti-Escherichia coli Bd2221/75, activity value is MIC = 39 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 0.8 uM||Anti-Streptococcus pyogenes w.t, activity value is MIC = 34 uM||Anti-Candida albicans w.t, activity value is MIC = 31 uM	cytotoxic T and NK cells, small intestine, domestic pig Sus scrofa|||ytotoxic T and NK cells, small intestine, domestic pig Sus scrofa|||cytotoxic T and NK cells, small intestine, domestic pig Sus scrofa|||Sus scrofa [pig]|||Sus scrofa (Pig)|||cytotoxic T and NK cells, small intestine, domestic pig Sus scrofa	Helix||Alpha helix	1	"Andersson M, Gunne H, Agerberth B, Boman A, Bergman T, Sillard R, Jörnvall H, Mutt V, Olsson B, Wigzell H, et al. 1995
 EMBO J. 1995 Apr 18;14(8):1615-25. PubMed.|||1995 Apr 18;14(8):1615-25. doi: 10.1002/j.1460-2075.1995.tb07150.x.|||EMBO J
. 1995 Apr 18;14(8):1615-25. doi: 10.1002/j.1460-2075.1995.tb07150.x.|||7737114|||EMBO J. 1995 Apr 18;14(8):1615-1625.|||EMBO J. 1995 Apr 18;14(8):1615-25. PubMed.|||EMBO J. 1995 Apr 18;14(8):1615-25. PubMed."	78	
FPDB00216	AP04818|||AP04818|||AP04819	" 
FLSLIPKAIKAVSALAKKL"	Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 2 uM||Anti-E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-A. baumannii BAA 747, activity value is MIC = 4 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 16 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-A. baumannii BAA 747, activity value is MIC = 2 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anticancer	amino acid substitution, amphibian peptide analog, animal-derived, natural derivative	Helix	PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||horse RBC: HC50 64 uM. It showed toxicity to both cancer and non-cancer cells.|||w90c6t7w1sexseowqbf1	Yin W, Yao J, Leng X, Ma C, Chen X, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, et al. 2024 Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098.|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI	19	
FPDB00217	AP04815	" 
FLSLIPHAISAVSALAKHL"	Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 2||Anti-E. coli ATCC 8739, activity value is MIC = 16 uM||Anti-A.baumannii BAA 747, activity value is MIC > 128 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 64 uM||Anti-P.aeruginosa ATCC 9027, activity value is MIC > 128 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anticancer	the skin secretion, Super Tiger Leg Monkey Tree Frog, Phyllomedusa tomopterna, Central America, South America|||the skin secretion, Super Tiger Leg Monkey Tree Frog, Phyllomedusa tomopterna, Central America, South America	Helix	PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||horse RBC: HC50 64 uM.|||w90c6t7w1sexseowqbf1	Yin W, Yao J, Leng X, Ma C, Chen X, Jiang Y, Wang T, Chen T, Shaw C, Zhou M, et al. 2024 Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI	19	
FPDB00224	AP04231	 FLPLLAGLAASFLPTIFCKISRKC	Anti-Gram+ E. faecalis ATCC 29212, activity value is MIC = 3.125 ug/ml||Anti-S. aureus ATCC 25923 or MDR ATCC 29213, activity value is MIC = 6.25 ug/ml||Anti-S. saprophytics ATCCBAA750, activity value is MIC = 6.25 ug/ml||Anti-S. epidermidis CI 1607BL1D39, activity value is MIC = 12.5 uM||Anti-S. haemolyticus CI 1607BLD590, activity value is MIC = 12.5 ug/ml||Anti-E. coli ATCC 25922, activity value is MIC = 100 ug/ml||Anti-E. hormaechei ATCC700323, activity value is MIC = 100 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 100 ug/ml||Anti-K.pneumoniae ATCC700603, activity value is MIC > 100 ug/ml||Anti-C. koseri CI 1611SED223, activity value is MIC = 50 ug/ml||Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis||Hemolytic||Antibiofilm||Anticancer	skin, Pelophylax nigromaculatus, East Asia|||skin, Pelophylax nigromaculatus, East Asia	N/A	"HC50(50% hemolytic concentration)value of 35.8 ug/ml|||At a concentration of 3.125 µg/ml, the hemolytic activity on sheep red blood cells is not significant;  
When the concentration is >12.5 µg/ml, notable hemolysis occurs;  
50% hemolysis concentration|||The document provides core hemolytic data for the novel antimicrobial peptide Brevinin-1BW, with the following specific results: 
 
1. Key hemolytic indicators
 
Characteristics of concentration-dependent hemolysis: 
At a concentration of 3.125 ug/ml, Brevinin-1BW's hemolytic activity on sheep red blood cells (2% suspension) was not obvious, with almost no hemolytic effect. 
When the concentration exceeds 12.5 μg/ml, significant hemolysis begins, and the hemolysis rate increases with higher concentration. 
Its 50% hemolytic concentration (HC₅₀) is 35.8 ug/ml, meaning that at this concentration, 50% of sheep erythrocytes can be lysed (Figure 5B). 
Security Comparison: 
The effective antibacterial concentration (MIC) of Brevinin-1BW is much lower than its hemolytic activity-related concentration: against Gram-positive bacteria (such as Enterococcus faecalisis ATCC 29212 and Staphylococcus aureus ATCC 25923), the MIC is 3.125~6.25 ug/ml, both below 12.5 ug/ml (significant hemolysis onset concentration), indicating a low risk of hemolysis at effective antibacterial doses. 
 
2. Additional Explanation
 
Experimental conditions: Using 2% sheep red blood cell suspension, incubate Brevinin-1BW (3.125~100 ug/ml) at different concentrations with red blood cell suspension at 37°C for 2 hours; Using normal saline as the negative control (no hemolysis), 0.1% Triton X-100 as the positive control (complete hemolysis), after centrifugation, measure the absorbance of the supernatant at 570 nm. Calculate the hemolysis rate according to the formula: hemolysis rate % = (absorbance of negative control - absorbance of sample) / (absorbance of negative control - absorbance of positive control) × 100%. 
Hemolytic characteristics and associations: 
The hemolytic activity of Brevinin-1BW is related to its structure. As a member of the Brevinin-1 family, its C-terminus contains a ""Rana box"" disulfide bond structure and has high hydrophobicity (hydrophobicity index 0.838, Table 1). Excessive hydrophobicity may cause it to damage mammalian cell membranes at high concentrations, triggering hemolysis. 
Combined with cytotoxicity data (CC₅₀ for normal cells such as HaCaT and HUVEC both > 28 ug/ml, Table 4), it is further demonstrated that it has good biosafety within the range of potential clinical application concentrations (below 12.5 ug/ml)."	Chen Z, Wang L, He D, Liu Q, Han Q, Zhang J, Zhang AM, Song Y. 2024 Molecules. 2024 Mar 29;29(7):1534. doi: 10.3390/molecules29071534. PubMed|||. 2024 Mar 29;29(7):1534. doi: 10.3390/molecules29071534.|||Molecules. 2024 Mar 29;29(7):1534. doi: 10.3390/molecules29071534. PubMed|||Molecules. 2024 Mar 29;29(7):1534. doi: 10.3390/molecules29071534. PubMed	24	
FPDB00231	AP03721	ALWKSILKNAGKAALNEINQIV	Anti-S. aureus ATCC CRM 6538, activity value is MIC = 8 uM||Anti-MRSA NCTC 12493, activity value is MIC > 128 uM||Anti-E.faecalis NCTC 12697, activity value is MIC > 128 uM||Anti-or NCTC 13846, activity value is MIC = 2||Anti-K. pneumoniae ATCC 43816, activity value is MIC = 16 uM||Anti-P. aeruginosa ATCC CRM 9027, activity value is MIC = 32 uM||Anti-A. baumannii ATCC BAA 747, activity value is MIC = 16 uM||Anti-and C.albicans ATCC CRM 10231, activity value is MIC > 128 uM||Anti-active against S. aureus ATCC CRM 6538, activity value is MIC = 8 uM	Skin Secretion, Brown-belly leaf frog, Phyllomedusa Tarsius , South America	Helix	N/A	Ma X, Chen Y, Shu A, Jiang Y, Chen X, Ma C, Zhou M, Wang T, Chen T, Shaw C, Wang L. 2023 Molecules. 2023 Sep 11;28(18):6558. doi: 10.3390/molecules28186558. Pub-Med.|||2023 Sep 11;28(18):6558. doi: 10.3390/molecules28186558.	22	
FPDB00321	AP00605|||AP00605|||AP00606|||CAMPSQ2810|||DRAMP01754	ILPILSLIGGLLGK	Anti-Gram+||anti-sepsis||Antibiofilm||Anticancer||Anti-S. lactis, activity value is MIC = 41 uM||Anti-Staphylococcus aureus, activity value is MIC = 41 uM||Anti-Bacillus cereus, activity value is MIC = 41 uM||Anti-Streptococcus lactis, activity value is MIC = 41 uM||Anti-Escherichia coli, activity value is MIC > 100 uM	Rana chensinensis, China, Asia|||Rana chensinensis, China, Asia (also: peptide conjugates)|||Rana chensinensis, China, Asia|||Rana chensinensis [Chinese brown frog]|||Rana chensinensis (Chinese brown frog)	Helix	"The 50% hemolytic concentration (LD_{50}) of brevinin-1CEa on human red blood cells is 48 μM. The 50% hemolytic concentration (LD_{50}) of temporin-1CEa on human red blood cells is 230 μM. The 50% hemolytic concentration (LD_{50}) of temporin-1CEb on human red blood cells is 112 μM. The 50% hemolytic concentration (LD_{50}) of chensinin-1 on human red blood cells is >500 μM.|||The document mentioned hemolysis-related content. The specific hemolysis values are as follows:

- Brevinin-1CEa: The concentration causing 50% hemolysis of human red blood cells (LD₅₀) is 48 uM.
- Temporin-1CEa: LD₅₀ is 230 uM.
- Temporin-1CEb: LD₅₀ is 112 uM.
- Chensinin-1: No hemolytic activity at a concentration of 500 uM (LD₅₀ > 500 uM).|||The hemolytic values of antimicrobial peptides synthesized in the skin of Chinese brown frogs (Rana chensinensis), as explicitly mentioned in the document, measured against human red blood cells (expressed as half-maximal hemolytic concentration LD_{50}), are as follows:

- The hemolytic value LD_{50} of Brevinin-1CEa is 48 μM;
- The hemolytic value LD_{50} of Temporin-1CEa is 230 μM;
- The hemolytic value LD_{50} of Temporin-1CEb is 112 μM;
- The hemolytic value LD_{50} of the novel peptide Chensinin-1 is greater than 500 μM (i.e., no obvious hemolytic activity is observed even at 500 μM).

Note: LD_{50} refers to the peptide concentration that causes 50% hemolysis of red blood cells; lower values indicate stronger hemolytic activity. Among them, Brevinin-1CEa has the strongest hemolytic activity (LD_{50} = 48 μM), and Chensinin-1 has the weakest."	"Zoolog Sci. 2009 Mar;26(3):220-6. PubMed|||2009 Mar;26(3):220-6. doi: 10.2108/zsj.26.220.|||Zoolog Sci
. 2009 Mar;26(3):220-6. doi: 10.2108/zsj.26.220.||Shang D et al., 2014|||19341344|||Zoolog Sci. 2009 Mar;26(3):220-6. PubMed."	14	
FPDB00349	AP01161	GRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLR	Anti-Gram+ & Gram-||Antifungal||candidacidal||Antiparasitic||Chemotactic||anti-TB||anti-sepsis||Synergistic AMPs||Hemolytic||Anticancer||a recombinant peptide showed activity in vitro against bacteria (S. typhimurium||L. monocytogenes||E. coli||and S. aureus)||fungi C. neoformans||C. albicans||and parasites L. major||and parasites L. major.	NK cells; T lymphocytes; Homo sapiens|||gammadelta T cells, NK cells; T lymphocytes; Homo sapiens|||gammadelta T cells, NK cells; T lymphocytes; Homo sapiens|||NK cells; T lymphocytes; Homo sapiens	Helix	. Eluted fractions were all individually assayed for hemolytic activity. The fractions with the highest hemolytic activity were pooled and concentrated for use.	Science. 1998 Oct 2;282(5386):121-5. Pub-Med.|||1998 Oct 2;282(5386):121-5. doi: 10.1126/science.282.5386.121.||see the ref|||1998 Oct 2;282(5386):121-5. doi: 10.1126/science.282.5386.121.|||Science. 1998 Oct 2;282(5386):121-5. Pub-Med.||see the ref|||Science. 1998 Oct 2;282(5386):121-5. Pub-Med.	74	
FPDB00362	AP01328|||2925|||2926|||2927|||2928|||2929|||2930|||2931|||2932|||2933|||2934|||2935|||2936|||2937|||2938|||2939|||2940|||2941|||2942|||2943|||2944|||2945|||2946|||2947|||2948|||AP01328|||Epinecidin-1|||DRAMP21241	GFIFHIIKGLFHAGKMIHGLV	Anti-Gram+ & Gram-||Antiviral||Antifungal||Antiparasitic||Anti-MRSA||Anti-inflammatory||anti-sepsis||Wound healing||Anticancer||45% Cytotoxicity at 50 ug/ml||38% Cytotoxicity at 25 ug/ml||75% Cytotoxicity at 50 ug/ml||65% Cytotoxicity at 25 ug/ml||75 % Cytotoxicity at 50 ug/ml||83% Cytotoxicity at 50 ug/ml||77 % Cytotoxicity at 25 ug/ml||82 % Cytotoxicity at 50 ug/ml||85 % Cytotoxicity at 25 ug/ml||42 % Cytotoxicity at 12.5 ug/ml||41 % Cytotoxicity at 6.25 ug/ml||39 % Cytotoxicity at 3.125 ug/ml||90 % Cytotoxicity at 50 ug/ml||95 % Cytotoxicity at 25 ug/ml||45 % Cytotoxicity at 12.5 ug/ml||25 % Cytotoxicity at 6.25 ug/ml||25 % Cytotoxicity at 3.125 ug/ml||95 % Cytotoxicity at 50 ug/ml||96 % Cytotoxicity at 25 ug/ml||46 % Cytotoxicity at 12.5 ug/ml||Anti-ntiviral activity against foot-and-mouth disease virus in vitro, activity value is EC50 = 0.6 ug/ml||Anti-Antiviral activity against foot-and-mouth disease virus in vitro, activity value is EC50 = 0.6 ug/ml||Anti-17570764: Listeria monocytogenes, activity value is MIC = 50 ug/ml||Anti-Micrococcus luteus, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 12.5 ug/ml||Anti-Streptococcus pyogenes, activity value is MIC = 25 ug/ml||Anti-Streptococcus agalactiae, activity value is MIC = 50 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC > 100 ug/ml||Anti-Staphylococcus sp, activity value is MIC = 50 ug/ml||Anti-Staphylococcus xylosus, activity value is MIC = 50 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 25 ug/ml||Anti-Staphylococcus aureus subsp, activity value is MIC = 6.25 ug/ml||Anti-Enterobacter aerogenes, activity value is MIC = 50 ug/ml||Anti-Enterobacter cloacae subsp, activity value is MIC = 100 ug/ml||Anti-Vibrio alginolyticus, activity value is MIC = 12.5 ug/ml||Anti-Klebsiella oxytoca, activity value is MIC = 100 ug/ml||Anti-Salinivibrio costicola subsp, activity value is MIC = 12.5 ug/ml||Anti-Vibrio vulni cus, activity value is MIC = 50 ug/ml||Anti-Vibrio harveyi, activity value is MIC = 12.5 ug/ml||Anti-Vibrio vulnicus, activity value is MIC = 12.5 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 60 ug/ml||Anti-Yersinia enterocolitica subsp, activity value is MIC = 100 ug/ml||Anti-Carbapenem-resistant K. pneumoniae Bacterial isolates CRKP-1, activity value is MIC = 8000 ug||Anti-CRKP-2, activity value is MIC = 16000 ug||Anti-CRKP-3, activity value is MIC = 8000 ug||Anti-CRKP-4, activity value is MIC = 8000 ug||Anti-CRKP-5, activity value is MIC = 8000 ug||Anti-CRKP-6, activity value is MIC = 16000 ug||Anti-CRKP-7, activity value is MIC = 8000 ug||Anti-CRKP-8, activity value is MIC = 8000 ug||Anti-CRKP-9, activity value is MIC = 8000 ug||Anti-CRKP-10, activity value is MIC = 4000 ug||Anti-CRKP-11, activity value is MIC = 4000 ug||Anti-CRKP-12, activity value is MIC = 16000 ug||Anti-CRKP-13, activity value is MIC = 16000 ug||Anti-CRKP-14, activity value is MIC = 8000 ug||Anti-CRKP-15, activity value is MIC = 4000 ug||Anti-CRKP-16, activity value is MIC = 8000 ug||Anti-CRKP-17, activity value is MIC = 8000 ug||Anti-CRKP-18, activity value is MIC = 8000 ug||Anti-CRKP-19, activity value is MIC = 8000 ug||Anti-CRKP-20, activity value is MIC = 8000 ug||Anti-CRKP-21, activity value is MIC = 8000 ug||Anti-CRKP-22, activity value is MIC = 16000 ug||Anti-CRKP-23, activity value is MIC = 16000 ug||Anti-Carbapenem-resistant K. aerogenes Bacterial isolates CRKA-1, activity value is MIC = 16000 ug||Anti-CRKA-2, activity value is MIC = 8000 ug||Anti-CRKA-3, activity value is MIC = 4000 ug||Anti-CRKA-4, activity value is MIC = 16000 ug||Anti-CRKA-5, activity value is MIC = 4000 ug||Anti-CRKA-6, activity value is MIC = 16000 ug||Anti-CRKA-7, activity value is MIC = 4000 ug||Anti-CRKA-8, activity value is MIC = 8000 ug||Anti-CRKA-9, activity value is MIC = 16000 ug||Anti-CRKA-10, activity value is MIC = 8000 ug||Anti-CRKA-11, activity value is MIC = 4000 ug||Anti-CRKA-12, activity value is MIC = 8000 ug||Anti-CRKA-13, activity value is MIC = 16000 ug||Anti-CRKA-14, activity value is MIC = 8000 ug||Anti-CRKA-15, activity value is MIC = 8000 ug||Anti-CRKA-16, activity value is MIC = 8000 ug||Anti-CRKA-17, activity value is MIC = 4000 ug||Anti-Carbapenem-resistant P. aeruginosa Bacterial isolates CRPA-1, activity value is MIC = 8000 ug||Anti-CRPA-2, activity value is MIC = 16000 ug||Anti-CRPA-3, activity value is MIC = 8000 ug||Anti-CRPA-4, activity value is MIC = 16000 ug||Anti-CRPA-5, activity value is MIC = 16000 ug||Anti-CRPA-6, activity value is MIC = 8000 ug||Anti-CRPA-7, activity value is MIC = 4000 ug||Anti-CRPA-8, activity value is MIC = 16000 ug||Anti-CRPA-9, activity value is MIC = 8000 ug||Anti-CRPA-10, activity value is MIC = 16000 ug||Anti-CRPA-11, activity value is MIC = 16000 ug||Anti-CRPA-12, activity value is MIC = 16000 ug||Anti-CRPA-13, activity value is MIC = 32000 ug||Anti-Carbapenem-resistant A. baumannii Bacterial isolates CRAB-1, activity value is MIC = 32000 ug||Anti-CRAB-2, activity value is MIC = 32000 ug||Anti-CRAB-3, activity value is MIC = 4000 ug||Anti-CRAB-4, activity value is MIC = 16000 ug||Anti-CRAB-5, activity value is MIC = 32000 ug||Anti-CRAB-6, activity value is MIC = 16000 ug||Anti-CRAB-7, activity value is MIC = 32000 ug||Anti-CRAB-8, activity value is MIC = 8000 ug||Anti-CRAB-9, activity value is MIC = 16000 ug||Anti-Methicillin-resistant S. aureus Bacterial isolates MRSA-1, activity value is MIC = 16000 ug||Anti-MRSA-2, activity value is MIC = 16000 ug||Anti-MRSA-3, activity value is MIC = 32000 ug||Anti-MRSA-4, activity value is MIC = 8000 ug||Anti-MRSA-5, activity value is MIC = 16000 ug||Anti-MRSA-6, activity value is MIC = 8000 ug||Anti-MRSA-7, activity value is MIC = 8000 ug||Anti-MRSA-8, activity value is MIC = 16000 ug||Anti-MRSA-9, activity value is MIC = 32000 ug||Anti-MRSA-10, activity value is MIC = 16000 ug||Anti-MRSA-11, activity value is MIC = 16000 ug||Anti-MRSA-12, activity value is MIC = 16000 ug||Anti-MRSA-13, activity value is MIC = 16000 ug||Anti-MRSA-14, activity value is MIC = 16000 ug||Anti-MRSA-15, activity value is MIC = 16000 ug||Anti-MRSA-16, activity value is MIC = 16000 ug||Anti-MRSA-17, activity value is MIC = 8000 ug||Anti-MRSA-18, activity value is MIC = 16000 ug||Anti-MRSA-19, activity value is MIC = 16000 ug||Anti-MRSA-20, activity value is MIC = 16000 ug||Anti-MRSA-21, activity value is MIC = 16000 ug||Anti-MRSA-22, activity value is MIC = 8000 ug||Anti-Micrococcus luteus, activity value is MIC = 6.25 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 50 ug/ml||Anti-Streptococcus pneumoniae, activity value is MIC = 50 ug/ml||Anti-Streptococcus agalactiae, activity value is MIC >= 100 ug/ml||Anti-Staphylococcus sp, activity value is MIC = 6.25 ug/ml||Anti-##Gram-negative bacteria : Grouper Vibrio alginolyticus, activity value is MIC = 6.25 ug/ml||Anti-Vibrio harveyi, activity value is MIC = 6.25 ug/ml||Anti-Vibrio vulnificus, activity value is MIC = 50 ug/ml	orange-spotted grouper, Epinephelus coioides|||orange-spotted grouper, Epinephelus coioides|||orange-spotted grouper, Epinephelus coioides|||Epinephelus coioides [orange-spotted grouper]|||Synthetic construct	N/A	gene|||hRBC(100% hemolysis at 156.25 ug/ml)|||[Ref.23598079] 0% hemolysis at 25 ug/ml , 10% hemolysis at 50 ug/ml , 15% hemolysis at 100 ug/ml , 30% hemolysis at 200 ug/ml , 50% hemolysis at 400 ug/ml against sheep red blood cells	DNA Cell Biol. 2007 Jun;26(6):403-13|||DNA Cell Biol. 2007 Jun;26(6):403-13|||30552913, 28882626, 17570764, 35052952||Refer 28882626||Refer Pubmed ID 35052952|||Peptides. 2013 Jun;44:139-48. doi: 10.1016/j.peptides.2013.04.004.||Ref.23598079	21	L
FPDB00418	AP02135|||AP02135|||TP4|||DRAMP018494|||TP4|||AP02135	"	
FIHHIIGGLFSAGKAIHRLIRRRRR"	Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis||Hemolytic||Wound healing||Anticancer||Anti-Gram-negative V. vulnificus 204, activity value is MIC = 0.03 ug/ml||Anti-A. hydrophila BCRC 13018, activity value is MIC = 1.05 ug/ml||Anti-V. alginolyticus, activity value is MIC = 0.03 ug/ml||Anti-P. aeruginosa ATCC 19660, activity value is MIC = 0.52 ug/ml||Anti-S. agalactiae 819, activity value is MIC = 2.1 ug/ml||Anti-E. faecalis BCRC 10066, activity value is MIC = 8.39 ug/ml||Anti-which is active against S. aureus, activity value is MIC = 5 uM||Anti-B. subtilis, activity value is MIC = 1.7 uM||Anti-E. tarda, activity value is MIC = 20 uM||Anti-Vibrio vulnificus 204, activity value is MIC = 0.03 ug/ml||Anti-Aeromonas hydrophila BCRC 13018, activity value is MIC = 1.05 ug/ml||Anti-Vibrio alginolyticus, activity value is MIC = 0.03 ug/ml||Anti-Pseudomonas aeruginosa ATCC 19660, activity value is MIC = 0.52 ug/ml||Anti-Streptococcus agalactiae 819, activity value is MIC = 2.1 ug/ml||Anti-S. agalactiae BCRC 10787, activity value is MIC = 0.13 ug/ml||Anti-P. aeruginosa, activity value is MIC = 64 ug/ml||Anti-S. aureus, activity value is MIC = 8 ug/ml||Anti-MRSA, activity value is MIC = 16 ug/ml||Anti-C. albicans, activity value is MIC = 128 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 8 ug/ml||activity value is MBC = 16 ug/ml||Anti-Methicillin-resistant Staphylococcus aureus, activity value is MIC = 16 ug/ml||activity value is MBC = 32 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC = 64 ug/ml||activity value is MBC = 128 ug/ml||Anti-Candida albicans, activity value is MIC = 128 ug/ml	gills, Nile Tilapia, Oreochromis niloticus|||gills, Nile Tilapia, Oreochromis niloticus|||Oreochromis niloticus [Nile tilapia]|||Oreochromis niloticus|||Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)|||Oreochromis niloticus|||gills, Nile Tilapia, Oreochromis niloticus	Helix||Alpha helix	"were hemolytic in fish red blood cells at 100000 ug/ml for 100% hemolysis|||TP1 and TP5 showed no hemolytic activity at a concentration of 100 µg/ml. TP2 had a hemolysis rate of 60% at a concentration of 40 µg/ml. TP3 had a hemolysis rate of 42% at a concentration of 100 µg/ml. TP4 had a hemolysis rate of 100% at a concentration of 100 µg/ml.|||gills, Nile Tilapia, Oreochromis niloticus||HC₅₀ = 5 uM。|||Mouse erythrocytes (100% hemolysis, 25 ug/ml)|||Mouse erythrocytes (100% hemolysis, 25 ug/ml)|||. TP4 presented excellent antimicrobial
activity compared to cod pis 1 and grouper epinecidin-1.
Furthermore, the TP1,5 synthetic peptides were assayed for
hemolytic activities in fish blood cells. The TP1 and TP5 synthetic
peptides showed no hemolytic activity, and even when treated with
100000 ug/ml peptide, no hemolytic activity was detected (Fig. 5). In
contrast, TP4 and TP3 were hemolytic in fish red blood cells at
100000 ug/ml for 100% hemolysis and 42% hemolysis, respectively
(Fig. 5). TP2 achieved 60% hemolysis at 40000 ug/ml.|||fish RBCs, HC50 50 ug/ml, moderate hemolytic."	"PLoS One. 2012;7(11):e50263. Pub-Med.|||2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30.||Kuo et al., 2018||Ting CH et al., 2016|||PLoS One. 2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30.||Kuo et al., 2018||Ting CH et al., 2016|||23226256|||29040295|||PLoS One. 2017 Oct 17;12(10):e0186442.||Ref.29040295|||29040295|||PLoS One
. 2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30||Kuo et al., 2018||Ting CH et al., 2016|||PLoS One. 2012;7(11):e50263. Pub-Med."	25	
FPDB00428	AP02253|||AP02253|||Chensinin-1b|||DRAMP20841	"	
SKVWRHWRRFWHRAHRLH"	Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis||Wound healing||Anticancer||Anti-S. aureus, activity value is MIC = 3.13 uM||Anti-S. epidermidis MRSE1208, activity value is MIC = 12.5 uM||Anti-B. cereus, activity value is MIC = 3.13 uM||Anti-S. lactis, activity value is MIC = 3.13 uM||Anti-E. faecalis, activity value is MIC = 1.56 uM||Anti-E. faecium, activity value is MIC = 3.13 uM||Anti-E. coli, activity value is MIC = 6.25 uM||Anti-E-cloacae, activity value is MIC > 50 uM||Anti-P-fluorescens MRPF0322, activity value is MIC > 50 uM||Anti-and P. aeruginosa, activity value is MIC = 1.56 uM||Anti-E. coli MREC0203, activity value is MIC = 1.56 uM||Anti-S. aureus MRSA0910, activity value is MIC = 3.13 uM||Anti-E. faecium M, activity value is MIC = 6.25 uM||Anti-Escherichia coli, activity value is MIC = 6.25 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 1.56 uM||Anti-##Gram-positive bacteria:Staphylococcus aureus, activity value is MIC = 3.13 uM	amino acid substitution, amphibians, animal-derived, natural derivative|||Synthetic construct	Helix||Random coil conformation	no hemolytic activity|||All truncated Chensinin-1b analogs exhibited 50% hemolysis concentrations (HC₅₀) &gt;500 µM against human erythrocytes across the concentration range of 0.25–500 µM, indicating no significant hemolytic activity.|||amino acid substitution, amphibians, animal-derived, natural derivative||No obvious hemolytic activity was observed within the concentration range of 0.25–500 uM.|||[Ref.27060618] HC50>500 uM against human red blood cells	Acta Biomater. 2016 Jun;37:59-68. doi: 10.1016/j.actbio.2016.04.003. Pub-Med.|||2016 Jun:37:59-68. doi: 10.1016/j.actbio.2016.04.003. Epub 2016 Apr 6.|||Acta Biomater. 2016 Jun;37:59-68. doi: 10.1016/j.actbio.2016.04.003. Pub-Med.||Li et al., 2023|||28756209|||Acta Biomater. 2016 Jun;37:59-68.||Ref.27060618	18	
FPDB00481	1235|||1236|||1237|||1238|||AP00134|||AP00134|||Cecropin P1|||DRAMP03176|||Cecropin P1|||DRAMP21258	SWLSKTAKKLENSAKKRISEGIAIAIQGGPR	activity value is IC50 = 93 uM||IC50=>100 uM||Anti-Gram- L. anguillarum, activity value is MIC = 1.2 uM||Anti-E. coli, activity value is MIC = 1.2 uM||Anti-C. glutamicum, activity value is MIC = 1.6 uM||Anti-and S. aureus, activity value is MIC = 12.5 uM||Anti-L. monocytogenes EGD, activity value is MIC = 3||Anti-and P. aeruginosa MR3007, activity value is MIC = 0.3||Anti-E. coli ATCC 25922, activity value is MIC = 0.8||Anti-E. coli HB101, activity value is MIC = 0.8||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 0.8||Anti-C. glutamicum ATCC 13032, activity value is MIC = 0.4||Anti-S. cerevisiae spp, activity value is IC50 = 6.3 uM||Anti-C. albicans ATCC 10231, activity value is IC50 = 12.5 uM||Anti-B. cinerea 101, activity value is IC50 = 50 uM||Antibacterial||Anti-P1-NH2 : [E. coli K-12/ D21, activity value is MIC = 0.3 uM||Anti-E. coli 853/67/0149/K88, activity value is MIC = 0.9 uM||Anti-E. coli Bd2221/75/08/K88, activity value is MIC = 0.6 uM||Anti-E. coli Bd4462/84/0101/K99, activity value is MIC = 0.7 uM||Anti-E. coli Bd4466/84/064/K99, activity value is MIC = 0.3 uM||Anti-Salmonella typhimurium LT2, activity value is MIC = 0.9 uM||Anti-A. calcoaceticus Ac1l, activity value is MIC = 0.2 uM||Anti-Proteus vulgaris Pvll, activity value is MIC = 5.7 uM||Anti-Pseudomonas aeruginosa OT97, activity value is MIC = 5.9 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 1.8 uM||Anti-Streptococcus pyogenes, activity value is MIC = 19 uM||Anti-E. coli 853/67/0149/K88, activity value is MIC = 0.6 uM||Anti-E. coli Bd2221/75/08/K88, activity value is MIC = 0.7 uM||Anti-E. coli Bd4462/84/0101/K99, activity value is MIC = 0.8 uM||Anti-E. coli Bd4466/84/064/K99, activity value is MIC = 0.6 uM||Anti-Salmonella typhimurium LT2, activity value is MIC = 1.7 uM||Anti-A. calcoaceticus Ac1l, activity value is MIC = 0.5 uM||Anti-Proteus vulgaris Pvll, activity value is MIC = 12 uM||Anti-Pseudomonas aeruginosa OT97, activity value is MIC = 13 uM||Anti-Bacillus megaterium Bmll, activity value is MIC = 5.3 uM||Anti-Streptococcus pyogenes, activity value is MIC = 44 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC > 128 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC > 128 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC > 128 uM||Anti-Bacillus subtilis CMCC 63501, activity value is MIC = 1 uM||Anti-##Gram-negative bacteria : Escherichia coli ATCC25922, activity value is MIC = 0.5 uM||Anti-Escherichia coli UB1005, activity value is MIC = 0.5 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC > 128 uM||Anti-Salmonella typhimurium ATCC 7731, activity value is MIC = 2 uM||Anti-Salmonella pullorum C79-13, activity value is MIC = 0.5 uM	the large roundworm, Ascaris suum (living in pig)|||the large roundworm, Ascaris suum (living in pig)|||Synthetic construct|||Ascaris suum [Pig roundworm]|||Ascaris suum (Pig roundworm) (Ascaris lumbricoides)|||Synthetic construct|||Synthetic construct	Helix||Alpha helix	[Ref.29266746] MHC5>128 uM against human red blood cells	"1989 Dec;86(23):9159-62. doi: 10.1073/pnas.86.23.9159.||Lee IH et al., 1997|||Comparative Study Proc Natl Acad Sci U S A
. 1989 Dec;86(23):9159-62. doi: 10.1073/pnas.86.23.9159.||Lee IH et al., 1997|||23326415, https://doi.org/10.1046/j.1365-2761.1999.00191.x|||2512577, 11772394, 28544962|||Eur J Biochem. 1992 Oct 1;209(1):163-169.|||23326415, https://doi.org/10.1046/j.1365-2761.1999.00191.x|||Chem Biol Drug Des. 2018 May;91(5):1017-1029. doi: 10.1111/cbdd.13165.||Ref.29266746"	31	L
FPDB00884	AP00180|||DRAMP03595|||Human Defensin-5|||AP00180|||DRAMP03595|||AP00180|||DRAMP03595|||Human Defensin-5	ATCYCRTGRCATRESLSGVCEISGRLYRLCCR	"Anti-Gram+ & Gram-||Antiviral||Antifungal||Anti-toxin||anti-sepsis||Wound healing||Killed C. difficile. Human HD5 blocks papillomavirus infection (both cutaneous and mucosal papillomavirus types). HD-5 was particularly active against sexually transmitted HPV types  . HD-5 is active against pseudotyped viruses expressing SARS-CoV-2 spike proteins  .

It also results in decreased bacterial presence||enhanced wound healing||and hair growth from tissues devoid of adnexal structures (Lough D||et al.||2013).

It also neutralizes Clostridioides difficile Toxins TcdA||TcdB||and CDT  .||Killed C. difficile. Human HD5 blocks papillomavirus infection (both cutaneous and mucosal papillomavirus types). HD-5 was particularly active against sexually transmitted HPV types  . HD-5 is active against pseudotyped viruses expressing SARS-CoV-2 spike proteins  .||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Antiviral(SARS-CoV-2)||Antiviral(SARS-CoV-5)||Antiviral ; E. coli ATCC 25922 ( IC99 = 49.5 +/- 0.2 ug/ml)||S. aureus ATCC 29123 ( IC99 = 6.3 +/- 1.8 ug/ml)||C. albicans ATCC 99788 amphotericin B resistant ( IC90 > 100 ug/ml )||Adenovirus||Refer PubMed ID: A. baumannii 4-MRGN||K. pneumoniae 4-MRGN||P. aeruginosa ATCC27853||E. faecium 475747||B. longum||L. fermentum||L. salivarius||S. salivarius salivarius||Akkermansia muciniphila||B. subtilis 168trpC||S. aureus USA300||B. adolescentis Ni3.29c||B. breve||B. vulgatus DSM1447||L. rhamnosus||E. coli MC1000"	Paneth cells, intestine, urinary tract, Homo sapiens|||Homo sapiens (Human)|||Homo sapiens [Human]|||Paneth cells, intestine, urinary tract, Homo sapiens|||Homo sapiens (Human)|||Paneth cells, intestine, urinary tract, Homo sapiens|||Homo sapiens (Human)|||Homo sapiens	Beta||Beta strand	[Ref.26206286] It has 0% hemolysis at 100 uM against human red blood cells.	J. Biol. Chem. 1992; 267:23216-23225|||J. Biol. Chem. 1992; 267:23216-23225||Buck et al., 2006||Xu et al., 2021||Korbmacher et al. 2020|||Buck et al., 2006||Xu et al., 2021|||Viruses. 2021 Jun 26;13(7):1246.|||18191790 , 17088326, 30808760|||J. Biol. Chem. 1992; 267:23216-23225||Buck et al., 2006||Xu et al., 2021|||Viruses. 2021 Jun 26;13(7):1246.Nat Immunol. 2002 Jun;3(6):583-590.Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.|||J. Biol. Chem. 1992; 267:23216-23225||Buck et al., 2006||Xu et al., 2021|||Viruses. 2021 Jun 26;13(7):1246.|||https://pubmed.ncbi.nlm.nih.gov/18191790	32	
FPDB00898	AP00155|||DRAMP02912|||Cathelin-related peptide SC5|||AP00155	RGLRRLGRKIAHGVKKYGPTVLRIIRIAG	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anti-E. coli ATCC 25922 or ML-35 or D21, activity value is MIC = 0.12||Anti-S. enterica serovar typhimurium ATCC 14028, activity value is MIC = 0.25 uM||Anti-P. aeruginosa ATCC 27853 or 2 clinical isolates, activity value is MIC = 0.25||Anti-S. marcescens ATCC 8100, activity value is MIC = 0.25 uM||Anti-P-vulgaris ATCC 13315, activity value is MIC > 80 uM||Anti-S. aureus ATCC 25923 or Cowan 1 MRSA clinical isolate, activity value is MIC = 0.5||Anti-S. epidermidis ATCC 12228, activity value is MIC = 0.25 uM||Anti-E. faecalis ATCC 29212 or V clinical isolate, activity value is MIC = 1 uM||Anti-B. megaterium Bm11, activity value is MIC = 0.25 uM||Anti-C. albicans clinical isolate, activity value is MIC = 4 uM||Anti-C. neoformans 3 clinical isolates, activity value is MIC = 1 uM||Anti-and R. rubra, activity value is MIC = 0.5 uM||Anti-Escherichia coli DH5a, activity value is MIC = 0.1 uM||Anti-Escherichia coli ML-35p, activity value is MIC = 0.18 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 0.17 uM||Anti-Pseudomonas aeruginosa MR3007, activity value is MIC = 0.34 uM||Anti-Staphylococcus aureus ATCC 33591, activity value is MIC = 1.24 uM||Anti-Staphylococcus aureus 93918, activity value is MIC = 0.31 uM||Anti-Escherichia coli ML-35p, activity value is MIC = 0.12 uM||Anti-Pseudomonas aeruginosa PAO1, activity value is MIC = 0.08 uM||Anti-Pseudomonas aeruginosa MR3007, activity value is MIC = 0.18 uM||Anti-Staphylococcus aureus ATCC 33591, activity value is MIC = 0.65 uM||Anti-Staphylococcus aureus 93918, activity value is MIC = 0.43 uM||Anti-Staphylococcus aureus 25923, activity value is MIC = 5||Anti-Pseudomonas aeruginosa 27853, activity value is MIC = 5||Anti-Klebsiella pneumoniae 13883, activity value is MIC = 2.5||Anti-Candida albicans 14053, activity value is MIC = 10||Anti-pmid-10768969[ Pseudomonas aeruginosa PAO1, activity value is MIC = 0.17 uM||Anti-MRSA ATCC 33591, activity value is MIC = 1.24 uM	sheep leukocytes; Ovis aries|||Ovis aries (Sheep)|||Ovis aries [Sheep]|||sheep leukocytes; Ovis aries	Helix	N/A	"FEBS Lett. 1995 Dec 4;376(3):225-8. PubMed.|||1995 Dec 4;376(3):225-8. doi: 10.1016/0014-5793(95)01285-3.||Skerlavaj et al., 1999||Blower et al., 2018||Sousa et al., 2017|||Comparative Study FEBS Lett
. 1995 Dec 4;376(3):225-8. doi: 10.1016/0014-5793(95)01285-3.||Skerlavaj et al., 1999||Blower et al., 2018||Sousa et al., 2017|||Protein Eng. 2002 Mar;15(3):225-232.||Ref.8549789|||8549789|||FEBS Lett. 1995 Dec 4;376(3):225-8. doi: 10.1016/0014-5793(95)01285-3.||Skerlavaj et al., 1999||Blower et al., 2018||Sousa et al., 2017"	29	
FPDB00905	AP00418	GLRKRLRKFRNKIKEKLKKIGQKIQGFVPKLAPRTDY	Anti-Gram+ & Gram-||Anti-MRSA||anti-sepsis||This appears to be the first peptide in the cathelicidin family demonstrated to have antibacterial activity against various Gram-positive S. pneumoniae||S. pyogenes||and S. aureus or MRSA and Gram-negative bacteria E. coli HB101||K. pneumoniae||P. aeruginosa||and P. apacia. C-albicans (inactive at 20 ug/ml).||anti-sepsis  This appears to be the first peptide in the cathelicidin family demonstrated to have antibacterial activity against various Gram-positive S. pneumoniae	granulocytes, Rabbit, Oryctolagus cuniculus	Helix	"The document only mentions one hemolysis test result, with the key information as follows:

Hemolysis of 8 cathelicidin peptides and control peptide
All tested cathelicidin peptides (including LL-37, D-LL-37, SMAP-29, PG-1, mCRAMP, BMAP-28, NA-CATH, CAP-18) and the control peptide (scrambled LL-37), at a concentration of 100 µg/ml, did not show statistically significant hemolysis of defibrinated sheep red blood cells (the text explicitly states “no peptide demonstrated statistically significant hemolytic activity (p<0.001)”).

This concentration is 100 times that used to treat Bacillus anthracis infections in wax moth larvae (G. mellonella), and the document does not provide hemolysis data at other concentrations, nor does it mention hemolysis test results on the red blood cells of other species."	Antimicrob Agents Chemother. 1993 Dec;37(12):2534-9.|||Antimicrob Agents Chemother. 1993 Dec;37(12):2534-9	37	
FPDB00911	AP00548	RFGRFLRKIRRFRPKVTITIQGSARFG	Anti-Gram+ & Gram-||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm||Anti-Gram- E. coli ATCC 25922 or O157:H7 or PCN033 or RS218, activity value is MIC = 0.66||Anti-S. typhimurium ATCC 14028 or 700408, activity value is MIC = 0.66||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 0.66 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 5.32 uM||Anti-L. monocytogenes ATCC 19115, activity value is MIC = 1.33 uM||Anti-S. aureus ATCC 25923 or BAA-39 or 43300 MRSA, activity value is MIC = 0.33||Anti-MRSA WKZ-2, activity value is MIC = 5 uM||Anti-B. globigii TNO BMO13, activity value is MIC = 20 uM||Anti-E. coli ATCC 25922, activity value is MIC = 10 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 10 uM||Anti-P. aeruginosa PAO1, activity value is MIC = 20 uM||Anti-and S. enteriditis 706 RIVM, activity value is MIC = 10 uM	chicken, Gallus gallus	Helix	"This document focuses on the inflammatory response and coagulation abnormalities in dogs with idiopathic immune-mediated hemolytic anemia (IMHA). It does not directly provide quantitative hemolytic values (such as hemolysis rate, free hemoglobin concentration, etc.), but indirectly reflects hemolysis-related pathological states through the following indicators. The core data are as follows: 
 
1. Directly indicates key indicators of hemolysis
 
- Red blood cell-related indicators: 
The median hematocrit (Ht) in IMHA dogs (Group F, n=24) was 160 ml/L (range 60-340 ml/L), significantly lower than that of healthy dogs (Group A, median 500 ml/L) and other disease groups (e.g., sepsis group E median 320 ml/L, surgery group C median 380 ml/L), directly reflecting hemolysis-induced red blood cell loss. 
Clinical signs and tests related to hemolysis: 
Among 24 dogs with IMHA, 7 showed visible hemoglobinuria (indicating intravascular hemolysis), and 13 showed jaundice (due to elevated bilirubin after hemolysis). 
21 cases showed positive direct agglutination test (DAT), and 18 blood smears showed spherical red blood cells (all typical IMHA diagnostic criteria, reflecting hemolytic characteristics of red blood cells destroyed by antibodies). 
 
2. Indirectly related to hemolysis and coagulation and inflammatory indicators
 
Platelet parameters: 
The median platelet count (PLT) in IMHA patients was 200×10⁹/L (range 24-652×10⁹/L), which was higher than the DIC group (Group D, median 72×10⁹/L), but there was platelet activation and high turnover: median mean platelet volume (MPV) reached 19.4 fL (significantly higher than healthy dogs 11.6 fL and other disease groups), and median mean platelet mass (MPM) was 0.000003 μg, indicating increased compensatory platelet production associated with hemolysis and coagulation activation. 
Coagulation factor activity: 
In IMHA patients, except for increased activity of coagulation factors VIII (FVIII) and IX (FIX) (both are acute phase proteins that increase in response to inflammatory stimulation), the activities of other coagulation factors (FII, FV, FVII, FIX, FX, FXI, FXII) were all reduced, consistent with the characteristics of wasting thrombosis and indirectly reflected coagulation system activation triggered by hemolysis. 
Inflammatory indicators: 
The median white blood cell count (WBC) in IMHA dogs reached 33.5×10⁹/L (range 5.5-86.8×10⁹/L), significantly higher than that of healthy dogs (8.6×10⁹/L) and sepsis group (21.8×10⁹/L); Median monocyte count was 2.1×10⁹/L, median rod nucleoliocyte count was 1.3×10⁹/L, indicating a strong inflammatory response associated with post-hemolysis tissue damage and immune activation. 
 
In summary, the document does not provide traditional ""hemolytic values"" (such as hemolysis rate), but through hematocrit, hemoglobinuria, jaundice, DAT positivity, spherical red blood cells, and coagulation/inflammation indicators, it provides a comprehensive reflection of the hemolytic pathological status of dogs with IMHA. The median Ht of 160 ml/L is the core quantitative indicator for assessing hemolysis severity."	Vet. Immunol. Immunopathol. 106 (3-4), 321-327 (2005)|||Vet. Immunol. Immunopathol. 106 (3-4), 321-327 (2005)||Bosso et al., 2017	27	
FPDB00913	AP00557|||AP00557|||Cathelicidin|||DRAMP03644	RVKRVWPLVIRTVIAGYNLYRAIKKK	Anti-Gram+ & Gram-||Anti-MRSA||Anti-inflammatory||anti-sepsis||Anti-Gram- E. coli ATCC 25922 or O157:H7 or PCN033 or RS218, activity value is MIC = 0.8||Anti-S. typhimurium ATCC 14028 or 700408, activity value is MIC = 0.4||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 0.4 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 3.18 uM||Anti-L. monocytogenes ATCC 19115, activity value is MIC = 0.8 uM||Anti-S. aureus ATCC 25923 or BAA-39 or 43300 MRSA, activity value is MIC = 0.4||E. coli||E. coli O157:H7||S. typhimurium||S. typhimurium DT104||K. pneumoniae||P. aeruginosa||L. monocytogenes||S. aureus||S. aureus MRSA||Antimicrobial||Antibacterial||Anti-Gram+||Anti-Gram-||Cytolytic	chicken, Gallus galllus|||chicken, Gallus galllus|||chicken, Gallus galllus|||Gallus gallus [Chicken]|||Gallus gallus (Chicken)	Helix	"fowlicidin-{50}) is approximately 6-10 uM.

The 50% hemolytic concentration (EC_{50}) of fowlicidin-2 for human and chicken red blood cells is approximately 15-20 uM."	J Biol Chem. 2006 Feb 3;281(5):2858-67.|||J Biol Chem. 2006 Feb 3;281(5):2858-67.|||16326712|||Biol Chem. 2006 Feb 3;281(5):2858-2867.FEBS J. 2006 Jun;273(12):2581-2593.	26	
FPDB00922	AP00727|||AP00727|||Arenicin-1|||AR|||Arcycl|||DRAMP03173|||AP00727	RWCVYAYVRVRGVLVRYRRCW	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Anti-L. monocytogenes EGD, activity value is MIC = 0.6 ug/ml||Anti-negative E. coli ML-35p, activity value is MIC = 4 ug/ml||Antibacterial||Anti-Escherichia coli ML35p, activity value is MIC = 1||Anti-E. coli ATCC 25922, activity value is MIC = 2 uM||Anti-E. coli M15, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 2 uM||Anti-Listeria monocytogenes EGD, activity value is MIC = 1||Anti-Staphylococcus aureus 710A, activity value is MIC = 2 uM||Anti-S. aureus ATCC 25923, activity value is MIC = 2 uM||Anti-MRSA ATCC 33591, activity value is MIC = 4 uM||Anti-P. aeruginosa c.i, activity value is MIC = 4 uM||Anti-Acinetobacter baumanii c.i, activity value is MIC = 4 uM||Anti-Staphylococcus intermidius, activity value is MIC = 8 uM||Anti-S. aureus c.i, activity value is MIC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-Listeria monocytogenes EGD, activity value is MIC = 2 uM||Anti-P. aeruginosa c.i, activity value is MIC = 2 uM||Anti-Staphylococcus intermidius, activity value is MIC = 4 uM||Anti-S. aureus c.i, activity value is MIC = 4 uM||Anti-Listeria monocytogenes EGD, activity value is MIC = 0.6 ug/ml||Anti-Escherichia coli ML-35p, activity value is MIC = 4 ug/ml||Anti-E. coli WBB01, activity value is MIC = 300 uM||Anti-E. coli ATCC 23716, activity value is MIC = 600 uM||Anti-Salmonella enterica R595, activity value is MIC = 300 uM||Anti-S. enterica R60, activity value is MIC = 1250 uM||Anti-Proteus mirabilis R45, activity value is MIC = 600 uM	Arenicola marina|||Arenicola marina|||Synthetic construct|||Arenicola marina [Lugworm]|||Arenicola marina (Lugworm) (Lumbricus marinus)|||Arenicola marina	Beta||Beta strand (2 strands; 16 residues)	N/A	"FEBS Lett 2004; 577: 209-214. PubMed|||2004 Nov 5;577(1-2):209-14. doi: 10.1016/j.febslet.2004.10.012.|||FEBS Lett
. 2004 Nov 5;577(1-2):209-14. doi: 10.1016/j.febslet.2004.10.012.|||17935487|||31234579|||Biochem J. 2008 Feb 15;410(1):113-122.|||FEBS Lett 2004; 577: 209-214. PubMed"	21	
FPDB00947	AP01320|||AP01320|||Ostricacin-1	"	
LFCRKGTCHFGGCPAHLVKVGSCFGFRACCKWPWDV"	Anti-Gram+ & Gram-||Anti-MRSA||anti-sepsis||Antibacterial	Struthio camelus|||Struthio camelus|||Struthio camelus [Ostrich]	Bridge	N/A	Biotechnol Lett 2001; 23: 207-210|||Biotechnol Lett 2001; 23: 207-210|||16459058	36	
FPDB00948	AP01321|||AP01321|||Ostricacin-2|||DRAMP03286|||AP01321	APGNKAECEREKGYCGFLKCSFPFVVSGKCSRFFFCCKNIW	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Anti-S. aureus 1056 MRSA, activity value is MIC = 1.25 ug/ml||Anti-E. coli O157:H7, activity value is MIC = 0.96 ug/ml||Anti-and C. albicans 3153A, activity value is MIC = 6.2 ug/ml||Antibacterial||Anti-Staphylococcus aureus 1056-MRSA, activity value is MIC = 1.25 ug/ml||Anti-Escherichia coli O157:H7, activity value is MIC = 0.96 ug/ml||Anti-Candida albicans 3153A, activity value is MIC = 6.2 ug/ml	Struthio camelus|||Struthio camelus|||Struthio camelus [Ostrich]|||Struthio camelus (Ostrich)|||Struthio camelus	Bridge	"Table

Antimicrobial Peptide  Hemolytic Activity (RCH, %)  Test Concentration
OdA1  14.2±5.6  50 µg/ml
OdB1  None  50 µg/ml
OdC1  None  50 µg/ml
OdD1  None  50 µg/ml
Ode1  None  50 µg/ml
OdF1  None  50 µg/ml
OdG1  None  50 µg/ml
OdH1  None  50 µg/ml
OdI1  None  50 µg/ml
OdJ1  None  50 µg/ml
OdK1  None  50 µg/ml
OdL1  22.4±7.2  50 µg/ml
Odd1  7.7±3.5  50 µg/ml
OdN1  None  50 µg/ml
Odo1  None  50 µg/ml
OdP1a  None  50 µg/ml
OdP2a  None  50 µg/ml
Odd1  23.6±3.7  50 µg/ml
OdR1  None  50 µg/ml
Ods1  None  50 µg/ml
OdT1  None  50 µg/ml
OdU1  5.2±2.3  50 µg/ml
OdV1  None  50 µg/ml
OdW1  None  50 µg/ml
Nigrocin-OG2  18.1±7.7  50 µg/ml
Nigrocin-OG4  22.3±3.1  50 µg/ml
Nigrocin-OG5  14.0±5.2  50 µg/ml
Nigrocin-OG13  None  50 µg/ml
Nigrocin-OG20  None  50 µg/ml
Nigrocin-OG21  17.0±2.8  50 µg/ml

The experiment used the Triton X-100 treated group as the 100% hemolysis control. At this concentration, different antimicrobial peptides exhibited varying hemolytic activities. Some peptides showed no detectable hemolytic activity (NA), while others had a certain degree of hemolysis.|||The hemolytic activity (RCH) of certain peptides (such as odorranain-A1, etc.) was mostly NA (not detected) or low at the tested concentration (50 µg/mL); specific values can be found in the “RCH” column of Table III. For example, the hemolysis rates of odorranain-B1, -C1, and others did not exceed the statistically significant threshold.|||Hemolysis assay is a standard biological method to investigate cytotoxic effects of an agent on red blood cells. For brevinin-Eu and cyanophlyctin b, only 1.9% and 0.7% hemolytic activity was observed, respectively, at 500 lg/ mL in comparison with Triton-X-100 as positive control with 100% hemolysis. Low hemolytic activity makes them"	"Mol Cell Proteomics
. 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. Epub 2007 Jan 31.|||16459058|||Int J Antimicrob Agents. 2006 Mar;27(3):229-235.|||Int J Antimicrob Agents. 2006 Mar;27(3):229-35. Pub-Med.|||Int J Antimicrob Agents. 2006 Mar;27(3):229-35. Pub-Med."	41	
FPDB01021	AP02347|||DRAMP18305	"	
KVTKSVKSIPVKI"	Anti-Gram+ & Gram-||Anti-MRSA||anti-sepsis||Antifungal||candidacidal||Anti-inflammatory||Antimicrobial||Antibacterial	Paenibacillus thiaminolyticus OSY-SE	N/A	Paenibacillus thiaminolyticus OSY-SE	"Appl Environ Microbiol
. 2012 May;78(9):3156-65. doi: 10.1128/AEM.07782-11. Epub 2012 Feb 24.|||Vet. Immunol. Immunopathol. 106 (3-4), 321-327 (2005)|||Appl Environ Microbiol. 2012 May;78(9):3156-65. PubMed|||Appl Environ Microbiol. 2012 May;78(9):3156-65."	13	
FPDB01094	AP03179|||AP03179|||Brevinin-1GHd, Brevinin-1HL|||Brevinin-1GHd, Brevinin-1HL|||AP03179|||DRAMP29052	"	
FLGALFKVASKLVPAAICSISKKC"	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||Anti-inflammatory||anti-sepsis||Anti-S. aureus or MRSA, activity value is MIC = 2||Anti-E. coli, activity value is MIC = 8 uM||Anti-P. aeruginosa, activity value is MIC = 32 uM||Anti-C. albicans, activity value is MIC = 4 uM||Antibacterial||Anti-Staphylococcus aureus NCTC 10788, activity value is MIC = 2 uM||Anti-Staphylococcus aureus NCTC 10788, activity value is MBC = 4 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MIC = 4 uM||Anti-Staphylococcus aureus NCTC 12493, activity value is MBC = 4 uM||Anti-Escherichia coli NCTC 10418, activity value is MIC = 8 uM||Anti-Escherichia coli NCTC 10418, activity value is MBC = 8 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 32 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MBC = 32 uM||Anti-Candida albicans NCPE 1467, activity value is MIC = 4 uM||Anti-Candida albicans NCPE 1467, activity value is MBC = 8 uM||Anti-Human squamous lung carcinoma NCI-H157, activity value is IC50 = 2.987 uM||Anti-Human glioblastoma U251-MG, activity value is IC50 = 7.985 uM||Anti-Human breast adenocarcinoma MDA-MB-435S, activity value is IC50 = 1.197 uM||Anti-Human prostate adenocarcinoma PC-3, activity value is IC50 = 9.854 uM||Anti-Chromobacterium violaceum ATCC 12472, activity value is MIC = 205.2 uM||Anti-Chromobacterium violaceum ATCC 12472, activity value is MBC = 205.2 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MIC = 51.3 uM||Anti-Staphylococcus aureus ATCC 43300, activity value is MBC = 205.2 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MIC = 12.8 uM||Anti-Enterococcus faecalis NCTC 12697, activity value is MBC = 205.2 uM||Anti-Human lung adenocarcinoma NCI-H23, activity value is IC50 = 8.52||Anti-S. aureus, activity value is MIC = 2 uM||Anti-MRSA, activity value is MIC = 4 uM||Anti-##Gram-negative: E. coli, activity value is MIC = 8 uM||Anti-##Fungi: C. albicans, activity value is MIC = 4 uM	Hoplobatrachus rugulosus , China, Asia; skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia|||Sylvirana guentheri (Hylarana guentheri),Hylarana latouchii|||Sylvirana guentheri (Hylarana guentheri),Hylarana latouchii|||Hoplobatrachus rugulosus , China, Asia; skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia|||Sylvirana guentheri (Gunther's frog) (Rana guentheri)|||Hoplobatrachus rugulosus , China, Asia; skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia	Helix||α-helical	"In this document, the key values related to hemolysis for the novel antimicrobial peptide Brevinin-1GHa derived from the skin of the swamp frog (Hylarana guentheri) and its analogs Brevinin-1GHb and Brevinin-1GHc are as follows, determined by a horse red blood cell hemolysis assay (with 2% Triton X-100 as the 100% hemolysis positive control and PBS as the 0% hemolysis negative control):

Core Hemolytic Activity Results

- Test concentration range: 1–512 µM (covering the effective antimicrobial concentrations of the three peptides, with Brevinin-1GHa having an MIC against S. aureus of 2 µM, Brevinin-1GHb showing only weak activity against S. aureus with an MIC of 512 µM, and Brevinin-1GHc having an MIC against S. aureus of 16 µM)

- Hemolysis values of each peptide:

- Brevinin-1GHa (natural peptide containing a C-terminal Rana-box):
  - At a concentration of 16 µM, the hemolysis rate is close to 20%;
  - Its effective antimicrobial concentrations (e.g., MIC against S. aureus = 2 µM, MIC against C. albicans = 2 µM) are much lower than the concentration at which significant hemolysis occurs, indicating a low risk of hemolysis during antimicrobial activity, though there is still some hemolytic toxicity at higher concentrations.

- Brevinin-1GHb (truncated peptide lacking the Rana-box):
  - Only at a concentration of 512 µM does the hemolysis rate approach 20%;
  - This concentration is far higher than its sole antimicrobial active concentration (MIC against S. aureus = 512 µM), and it has no antimicrobial activity against other tested strains, indicating extremely low hemolytic toxicity but weak antimicrobial activity.

- Brevinin-1GHc (modified peptide with the Rana-box transferred to the central region):
  - At a concentration of 128 µM, the hemolysis rate approaches 20%;
  - Its effective antimicrobial concentration (e.g., MIC against S. aureus = 16 µM) is lower than the concentration at which significant hemolysis occurs, and its hemolytic activity is significantly lower than that of the natural peptide Brevinin-1GHa, although its antimicrobial activity is also slightly reduced compared to the natural peptide.|||At the highest MIC concentration (32 µM against Pseudomonas aeruginosa), the hemolysis rate of horse red blood cells was 13%; when the concentration was higher than 64 µM, the hemolysis rate gradually increased.|||Hoplobatrachus rugulosus , China, Asia; skin, Guenther's Frog, Sylvirana guentheri, Hylarana guentheri (old), Asia||Brevinin-1GHd shows 13% hemolysis at its highest MIC/MBC values|||Human microvascular endothelial cells HMEC-1 (50% Cell death at 15.62 uM, Human keratinocytes HaCat (50% Cell death at 29.69 uM|||Human microvascular endothelial cells HMEC-1 (50% Cell death at 15.62 uM, Human keratinocytes HaCat (50% Cell death at 29.69 uM|||Brevinin-1GHd shows 13% hemolysis at its highest MIC/MBC values|||[Ref.32347293] Brevinin-1GHd displayed 13% hemolysis on horse red blood cells at its highest MIC/MBC value of the tested bacteria P. aeruginosa (32 uM). However, when the concentration increased above 64 uM, the hemolytic activity of Brevinin-1GHd also gradually increased. At the concentration of 64, 128, 256 and 512 uM, it displayed about 36%, 64%, 83% and 108% hemolysis.|||Brevinin-1GHd displayed 13% hemolysis at its highest MIC/MBC value, indicating Brevinin-1GHd exhibited low hemolytic activity on horse red blood cells (Figure 6A). However, when the concentration increased above 64 uM, the hemolytic activity of Brevinin-1GHd also gradually increased."	"Biosci Rep
. 2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.|||2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.|||Biosci Rep
. 2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.|||32347293|||32347293|||Biosci Rep
. 2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.|||Biosci Rep. 2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.||Ref.32347293|||Biosci Rep. 2020;BSR20200019. doi:10.1042/BSR20200019. PubMed"	24	
FPDB01348	AP04602|||AP04602|||N2	"	
AFCWNVCVYRNAVRVCHRRCN"	Anti-Gram- bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7, activity value is MIC = 0.25||Anti-S. typhimurium ATCC14028, activity value is MIC = 1 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 0.125 ug/ml||Anti-S. pullorum CVCC1789 or CVCC1802, activity value is MIC = 0.25||Anti-S. choleraesuis CV, activity value is CC50 = 3||Anti-P. aeruginosa CICC10419 or CICC21630, activity value is MIC = 2 ug/ml||Anti-S. aureus ATCC43300 MRSA or ATCC25923, activity value is MIC = 0.25||Anti-S. suis CVCC606, activity value is MIC = 16 ug/ml||Anti-E. faecium CMCC1.2136, activity value is MIC = 4 ug/ml||Anti-B. subtilis ATCC6633, activity value is MIC = 0.5 ug/ml||Anti-L. ivanovii ATCC19119, activity value is MIC = 4 ug/ml||Anti-C. albicans CGMCC2.2411, activity value is MIC = 32 ug/ml||Anti-Escherichia coli CVCC195, activity value is MIC = 0.25 ug/ml||Anti-E. coli CVCC1515a, activity value is MIC = 0.5 ug/ml||Anti-E. coli CICC21530, activity value is MIC = 0.25 ug/ml||Anti-Salmonella typhimurium ATCC14028, activity value is MIC = 1 ug/ml||Anti-S. pullorum CVCC1789, activity value is MIC = 0.5 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 0.25 ug/ml||Anti-Pseudomonas aeruginosa CICC10419, activity value is MIC = 2 ug/ml||Anti-P. aeruginosa CICC21630, activity value is MIC = 2 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 16 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 0.25 ug/ml||Anti-Enterococcus faecium CMCC1.2136, activity value is MIC = 4 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 0.5 ug/ml||Anti-Listeria ivanovii ATCC19119, activity value is MIC = 4 ug/ml||Anti-Candida albicans CGMCC2.2411, activity value is MIC = 32 ug/ml||Anti-S. typhimurium, activity value is MIC = 0.78 uM	amino acid substitution, animal-derived, natural derivative|||amino acid substitution, animal-derived, natural derivative|||Synthetic construct	Beta	"N1: At a concentration of 128 µg/ml, hemolysis is 3%. N2: At a concentration of 128 µg/ml, hemolysis is 0.4%; at a concentration of 256 µg/ml, hemolysis is 3.8%. N6: At a concentration of 128 µg/ml, hemolysis is 0.04%; at a concentration of 256 µg/ml, hemolysis is 1.9%.|||At a concentration of 128 µg/mL, the hemolysis rate of mouse red blood cells was 0.4%; at a concentration of 256 µg/mL, the hemolysis rate was 3.8%.
At a concentration of N6:128 µg/mL, the hemolysis rate of mouse red blood cells was 0.04%; at a concentration of 256 µg/mL, the hemolysis rate was 1.9%.
At a concentration of 32 µg/mL, the parent peptide N1 exhibited a hemolysis rate of 3% (for comparative reference).|||murine RBC: 4% hemolysis at 256 ug/ml (low hemo.lytic)."	2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2.|||Sci Rep. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2. PubMed|||28611436|||29329001|||Sci Rep. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2. PubMed	21	
FPDB01350	AP04606|||AP04606|||N6|||N6-NH2-miniPEG|||N6-NH2-PEG6|||N6-NH2-PEG12|||N6-NH2-PEG24|||N6-COOH-miniPEG|||N6-NH2-miniPEG|||N6-NH2-PEG6|||N6-NH2-PEG12|||N6-NH2-PEG24|||N6-COOH-miniPEG|||DRAMP29066|||DRAMP29067	"	
GFAWNVCVYRNGVRVCHRRAN"	Anti-Gram- bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7, activity value is MIC = 0.5||Anti-S. typhimurium ATCC14028, activity value is MIC = 2 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 0.25 ug/ml||Anti-S. pullorum CVCC1789 or CVCC1802, activity value is MIC = 0.5 ug/ml||Anti-S. choleraesuis CV, activity value is CC50 = 3||Anti-P. aeruginosa CICC10419 or CICC21630, activity value is MIC = 4||Anti-S. aureus ATCC43300 MRSA or ATCC25923, activity value is MIC = 0.25||Anti-S. suis CVCC606, activity value is MIC = 16 ug/ml||Anti-E. faecium CMCC1.2136, activity value is MIC = 4 ug/ml||Anti-B. subtilis ATCC6633, activity value is MIC = 0.5 ug/ml||Anti-C. albicans CGMCC2.2411, activity value is MIC = 64 ug/ml||Anti-Escherichia coli CVCC195, activity value is MIC = 0.5 ug/ml||Anti-E. coli CVCC1515, activity value is MIC = 1 ug/ml||Anti-E. coli CICC21530, activity value is MIC = 0.5 ug/ml||Anti-Salmonella typhimurium ATCC14028, activity value is MIC = 2 ug/ml||Anti-S. pullorum CVCC1789, activity value is MIC = 0.5 ug/ml||Anti-S. pullorum CVCC1802a, activity value is MIC = 0.5 ug/ml||Anti-Pseudomonas aeruginosa CICC10419, activity value is MIC = 8 ug/ml||Anti-P. aeruginosa CICC21630, activity value is MIC = 4 ug/ml||Anti-Staphylococcus aureus ATCC43300, activity value is MIC = 16 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 0.25 ug/ml||Anti-S. suis CVCC606, activity value is MIC = 6 ug/ml||Anti-Enterococcus faecium CMCC1.2136, activity value is MIC = 4 ug/ml||Anti-Bacillus subtilis ATCC6633, activity value is MIC = 0.5 ug/ml||Anti-Candida albicans CGMCC2.2411, activity value is MIC = 64 ug/ml||Antibacterial||Antifungal||Anti-E. coli CVCC195, activity value is MIC = 16 ug/ml||Anti-S. typhimurium ATCC14028, activity value is MIC = 16 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 16 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 16 ug/ml||Anti-P. aeruginosa CICC21630, activity value is MIC = 64 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 128 ug/ml||Anti-S. typhimurium ATCC14028, activity value is MIC = 32 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa CICC21630, activity value is MIC = 128 ug/ml||Anti-E. coli CVCC195, activity value is MIC = 32 ug/ml||Anti-S. typhimurium ATCC14028, activity value is MIC = 64 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 32 ug/ml||Anti-E. coli CVCC195, activity value is MIC = 128 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 128 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 128 ug/ml||Anti-E. coli CVCC195, activity value is MIC = 8 ug/ml||Anti-S. typhimurium ATCC14028, activity value is MIC = 8 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 8 ug/ml||Anti-Staphylococcus aureus, activity value is MIC = 64 ug/ml||Anti-Edwardsiella tarda, activity value is MIC = 6.4 ug/ml||Anti-Aeromonas veronii, activity value is MIC = 6.4 ug/ml||Anti-E. coli CVCC25922, activity value is MIC = 0.25 ug/ml||Anti-E. coli CVCCO157, activity value is MIC = 0.5 ug/ml||Anti-Salmonella typhimurium CVCC533, activity value is MIC = 1 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 0.5 ug/ml||Anti-Pseudomonas aeruginosa CICC21630, activity value is MIC = 4 ug/ml||Anti-S. aureus ATCC546, activity value is MIC = 4 ug/ml||Anti-S. hyicus 437-2, activity value is MIC = 64 ug/ml||Anti-S. hyicus 15095, activity value is MIC = 16 ug/ml||Anti-Edwardsiella tarda, activity value is MIC = 0.5 ug/ml||Anti-Aeromonas veronii, activity value is MIC = 2 ug/ml||Anti-Escherichia coli CVCC195, activity value is MIC = 0.06 ug/ml||Anti-E. coli CVCC1515, activity value is MIC = 0.06 ug/ml||Anti-E. coli CVCC25922, activity value is MIC = 0.06 ug/ml||Anti-E. coli CVCCO157, activity value is MIC = 0.06 ug/ml||Anti-Salmonella typhimurium CVCC533, activity value is MIC = 0.25 ug/ml||Anti-S. typhimurium ATCC14028, activity value is MIC = 0.06 ug/ml||Anti-S. enteritidis CVCC3377, activity value is MIC = 0.06 ug/ml||Anti-S. pullorum CVCC1802, activity value is MIC = 0.25 ug/ml||Anti-S. pullorum CVCC1789, activity value is MIC = 0.06 ug/ml||Anti-Pseudomonas aeruginosa CICC21630, activity value is MIC = 0.06 ug/ml||Anti-S. aureus ATCC546, activity value is MIC = 1 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 1 ug/ml||Anti-S. hyicus 437-2, activity value is MIC = 16 ug/ml||Anti-S. hyicus 15095, activity value is MIC = 4 ug/ml	amino acid substitution, animal-derived, natural derivative|||amino acid substitution, animal-derived, natural derivative|||Synthetic construct|||Arenicola marina [Lugworm]|||Synthetic construct	Beta||β-turn, coil and antiparallel sheet	"N1: At a concentration of 128 µg/ml, hemolysis is 3%. N2: At a concentration of 128 µg/ml, hemolysis is 0.4%; at a concentration of 256 µg/ml, hemolysis is 3.8%. N6: At a concentration of 128 µg/ml, hemolysis is 0.04%; at a concentration of 256 µg/ml, hemolysis is 1.9%.|||At a concentration of 128 µg/mL, the hemolysis rate of mouse red blood cells was 0.4%; at a concentration of 256 µg/mL, the hemolysis rate was 3.8%.
At a concentration of N6:128 µg/mL, the hemolysis rate of mouse red blood cells was 0.04%; at a concentration of 256 µg/mL, the hemolysis rate was 1.9%.
At a concentration of 32 µg/mL, the parent peptide N1 exhibited a hemolysis rate of 3% (for comparative reference).|||E. coli CVCC195 (MIC= 16 ug/ml), S. typhimurium ATCC14028 (MIC= 16 ug/ml), S. pullorum CVCC1802 (MIC= 16 ug/ml), S. enteritidis CVCC3377 (MIC= 16 ug/ml), P. aeruginosa CICC21630 (MIC= 64 ug/ml), Staphylococcus aureus (ATCC 43300) (MIC= 128 ug/ml), S. hyicus NCTC10350 (MIC= >128 ug/ml), C. albicans CMCC98001 (MIC= >128 ug/ml)|||E. coli CVCC195 (MIC= 16 ug/ml), S. typhimurium ATCC14028 (MIC= 32 ug/ml), S. pullorum CVCC1802 (MIC= 16 ug/ml), S. enteritidis CVCC3377 (MIC= 32 ug/ml), P. aeruginosa CICC21630 (MIC= 128 ug/ml), Staphylococcus aureus (ATCC 43300) (MIC= >128 ug/ml), S. hyicus NCTC10350 (MIC= >128 ug/ml), C. albicans CMCC98001 (MIC= >128 ug/ml)|||E. coli CVCC195 (MIC= 32 ug/ml), S. typhimurium ATCC14028 (MIC= 64 ug/ml), S. pullorum CVCC1802 (MIC= 32 ug/ml), S. enteritidis CVCC3377 (MIC= 32 ug/ml), P. aeruginosa CICC21630 (MIC= >128 ug/ml), Staphylococcus aureus (ATCC 43300) (MIC= >128 ug/ml), S. hyicus NCTC10350 (MIC= >128 ug/ml), C. albicans CMCC98001 (MIC= >128 ug/ml)|||E. coli CVCC195 (MIC= 128 ug/ml), S. typhimurium ATCC14028 (MIC= >128 ug/ml), S. pullorum CVCC1802 (MIC= 128 ug/ml), S. enteritidis CVCC3377 (MIC= 128 ug/ml), P. aeruginosa CICC21630 (MIC= >128 ug/ml), Staphylococcus aureus (ATCC 43300) (MIC= >128 ug/ml), S. hyicus NCTC10350 (MIC= >128 ug/ml), C. albicans CMCC98001 (MIC= >128 ug/ml)|||E. coli CVCC195 (MIC= 8 ug/ml), S. typhimurium ATCC14028 (MIC= 8 ug/ml), S. pullorum CVCC1802 (MIC= 8 ug/ml), S. enteritidis CVCC3377 (MIC= 16 ug/ml), P. aeruginosa CICC21630 (MIC= 64 ug/ml), Staphylococcus aureus (ATCC 43300) (MIC= 64 ug/ml), S. hyicus NCTC10350 (MIC= >128 ug/ml), C. albicans CMCC98001 (MIC= >128 ug/ml)|||Hemolytic activity against Mouse RBCs|||No hemolysis information or data found in the reference(s) presented in this entry|||[Ref.33348729]The hemolysis of N6NH2 towards mouse erythrocytes was 0.19% at a concentration of 256 ug/ml, lower than that of N6 (1.9%), indicating their low hemolytic activity|||murine RBC: 2% hemolysis at 256 ug/ml (low hemo.lytic). Less toxic to RAW264.7 cells than Arenicin-3 analog N1."	2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2.|||Sci Rep. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2. PubMed|||28611436|||35549900|||35549900|||Mar Drugs. 2020 Dec 17;18(12):650. doi: 10.3390/md18120650.||Ref.33348729|||Sci Rep. 2017 Jun 13;7(1):3392. doi: 10.1038/s41598-017-03664-2. PubMed	21	
FPDB01354	AP04632|||AP04632|||CAMPSQ15069|||CAMPSQ15265|||DRAMP21147	"	
KRIVQRIKKWLR"	Anti-Gram- E. coli KCTC 1682, activity value is MIC = 2 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 8 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 1 uM||Anti-B. subtilis KCTC 3068, activity value is MIC = 8 uM||Anti-S. epidermidis KCTC 1917, activity value is MIC = 1 uM||Anti-and S. aureus KCTC 1621, activity value is MIC = 2 uM||Antibacterial||Anti-Bacillus subtilis, activity value is MIC = 8 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 2 uM||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 uM||Anti-Salmonella typhimurium, activity value is MIC = 1 uM	amino acid substitution, human cathelicidin analog, animal-derived, natural derivative|||amino acid substitution, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct	Helix||Random coil, alpha helix	"KR-12-a5: 96 uM KR-12-a6: 22 uM KR-12 and most other KR-12 analogs: did not show 50% hemolysis even at high concentrations (such as 800 uM)|||KR-12-a5: 50% hemolytic concentration (HC₅₀) is 96 μM; 
KR-12-a6: 50% hemolytic concentration (HC₅₀) is 22 μM; 
KR-12, KR-12-a1, KR-12-a2, KR-12-a3, KR-12-a4, KR-12-a7, KR-12-a8: did not reach 50% hemolysis at the highest tested concentration (800 μM) (HC₅₀ > 800 μM); 
Positive control (LL-37): 50% hemolytic concentration (HC₅₀) is 175 μM.|||human RBC (HC50 >800 uM), not hemo.lytic.|||hRBC ( HC50= >800 uM)|||[Ref.24105706] HC50>800 uM against human red blood cells"	2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. Epub 2013 Sep 17.|||J Pept Sci. 2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. PubMed|||35203875|||24105706|||J Pept Sci. 2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.||Ref.24105706	12	
FPDB01355	AP04633|||AP04633|||AP04634|||AP04635|||AP04633|||CAMPSQ15266|||DRAMP21148	"	
KRIVKRIKKWLR"	Anti-Gram- E. coli KCTC 1682, activity value is MIC = 2 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 8 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 2 uM||Anti-B. subtilis KCTC 3068, activity value is MIC = 2 uM||Anti-S. epidermidis KCTC 1917, activity value is MIC = 1 uM||Anti-and S. aureus KCTC 1621, activity value is MIC = 2 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 4 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 1 uM||Anti-B. subtilis KCTC 3068, activity value is MIC = 8 uM||Anti-Gram- E. coli KCTC 1682, activity value is MIC = 4 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 4 uM||Anti-B. subtilis KCTC 3068, activity value is MIC = 4 uM||Anti-and S. aureus KCTC 1621, activity value is MIC = 4 uM||Antibacterial||Anti-Bacillus subtilis, activity value is MIC = 2 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 2 uM||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 8 uM||Anti-Salmonella typhimurium, activity value is MIC = 2 uM	amino acid substitution, human cathelicidin analog, animal-derived, natural derivative|||amino acid substitution, human cathelicidin analog, animal-derived, natural derivative|||Homo sapiens [Human]|||Synthetic construct	Helix||Random coil, alpha helix	"KR-12-a5: 96 uM KR-12-a6: 22 uM KR-12 and most other KR-12 analogs: did not show 50% hemolysis even at high concentrations (such as 800 uM)|||KR-12-a5: 50% hemolytic concentration (HC₅₀) is 96 μM; 
KR-12-a6: 50% hemolytic concentration (HC₅₀) is 22 μM; 
KR-12, KR-12-a1, KR-12-a2, KR-12-a3, KR-12-a4, KR-12-a7, KR-12-a8: did not reach 50% hemolysis at the highest tested concentration (800 μM) (HC₅₀ > 800 μM); 
Positive control (LL-37): 50% hemolytic concentration (HC₅₀) is 175 μM.|||human RBC (HC50 >800 uM), not hemo.lytic. not toxic to RAW264.7 cells at 128 ug/ml.|||hRBC ( HC50= >800 uM)|||[Ref.24105706] HC50>800 uM against human red blood cells"	2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. Epub 2013 Sep 17.||see ref||ref new|||2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. Epub 2013 Sep 17.||see ref||ref new|||2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. Epub 2013 Sep 17.|||J Pept Sci. 2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. PubMed||see ref||ref new|||24105706|||J Pept Sci. 2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.||Ref.24105706	12	
FPDB01357	AP04668	"	
YGRKKRRQRRRKRIVQRIKDFLR"	Anti-Gram+ S. aureus ATCC 25923 or MRSA ATCC 43300, activity value is MIC = 16 ug/ml||Anti-S. epidermidis ATCC 35984 or MRSE ATCC 287, activity value is MIC = 8 ug/ml||Anti-and Gram- E. coli ATCC 25922, activity value is MIC = 16 ug/ml	peptide conjugates, designed, human cathelicidin analog, animal-derived, natural derivative	N/A	"Hemolytic values of TAT-KR-12: At concentrations up to 1024 μg mL⁻¹, TAT-KR-12 did not show any significant hemolytic activity (in two independent experiments, the hemolysis rate of TAT-KR-12 at 1024 μg mL⁻¹ was observed to be 0.5-1%).|||TAT-KR-12: Minimum hemolytic concentration (MHC, the concentration causing 10% hemolysis of human red blood cells) > 1024 µg/ml; 
KR-12: Minimum hemolytic concentration (MHC) > 1024 µg/ml; 
(Note: Determined by human red blood cell hemolysis assay, specific hemolysis rate values corresponding to concentrations are not mentioned, only the MHC threshold is specified)"	2020 Dec 11;6(12):3147-3162. doi: 10.1021/acsinfecdis.0c00264. Epub 2020 Nov 25.|||ACS Infect Dis. 2020 Dec 11;6(12):3147-3162. doi: 10.1021/acsinfecdis.0c00264. PubMed	23	
FPDB01362	AP04816|||AP04816|||AP04817	"	
FLSLIPKAISAVSALAKHL"	Anti-Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493, activity value is MIC = 4 uM||Anti-E. coli ATCC 8739, activity value is MIC = 8 uM||Anti-A.baumannii BAA 747, activity value is MIC > 128 uM||Anti-K. pneumonia ATCC 43816, activity value is MIC = 8 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 32 uM||Anti-and fungi C. albicans, activity value is MIC = 32 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-MRSA||anti-sepsis||Hemolytic||Antibiofilm	amino acid substitution, amphibian peptide analog, animal-derived, natural derivative	Helix	PSTO2: 21.787K: 21.9718K: 20.59SR: 12.60SR2: 6.53SRD7: 74.78SR2D10: 75.24D1/D2: No obvious hemolysis (>512 uM)|||horse RBC: HC50 32-64 uM.|||w90c6t7w1sexseowqbf1	https://doi.org/10.3390/pharmaceutics16081098|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098.|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI|||Pharmaceutics. 2024; 16(8):1098. https://doi.org/10.3390/pharmaceutics16081098. MDPI	19	
FPDB01466	AP00006|||AP00006|||Apidaecin-1A	GNNRPVYIPQPRPPHPRI	Anti-A. tumefaciens DSM 3129, activity value is MIC = 0.2 ug/ml||Anti-E. salicis NCPPB 2530, activity value is MIC = 0.02 ug/ml||Anti-E. coli NCTC 9001, activity value is MIC = 0.1 ug/ml||Anti-P. syringae pv. tomamta NCPPB 1105, activity value is MIC = 0.2 ug/ml||Anti-R. meliloti ZB 314, activity value is MIC = 0.1 ug/ml||Anti-S. Newport CD 94, activity value is MIC = 0.2 ug/ml||Anti-S. enterica serovar typhimurium ATCC 23565, activity value is MIC = 0.1 ug/ml||Anti-S.marcescens ATCC 17991, activity value is MIC > 200 ug/ml||Anti-S. flexneri CP 87, activity value is MIC = 0.1 ug/ml||Anti-C. insidiosum NCPPB 1109, activity value is MIC = 50 ug/ml||Anti-B. alvei LMG 6922, activity value is MIC > 200 ug/ml||Anti-B.megaterium OMB 1551, activity value is MIC = 150 ug/ml||Anti-B.subtilis NRRL-B-237, activity value is MIC > 200 ug/ml||Anti-and B.thuringiensis tenebrionis DSM 2803, activity value is MIC > 200 ug/ml||Anti-Gram+ & Gram-||anti-sepsis||Anti-Agrobacterium tumefaciens, activity value is MIC = 0.2 ug/ml||Anti-Erwinia salicis, activity value is MIC = 0.02 ug/ml||Anti-Escherichia coli, activity value is MIC = 0.1 ug/ml||Anti-Pseudomonas syringae, activity value is MIC = 0.2 ug/ml||Anti-Rhizobium meliloti, activity value is MIC = 0.1 ug/ml||Anti-Salmonella Newport, activity value is MIC = 0.2 ug/ml||Anti-Salmonella typhimurium, activity value is MIC = 0.1 ug/ml||Anti-Shigella flexneri, activity value is MIC = 0.1 ug/ml||Anti-Corynebacterium insidiosum, activity value is MIC = 50 ug/ml||Anti-Bacillus megaterium, activity value is MIC = 150 ug/ml	honeybee, Apis mellifera L.|||honeybee, Apis mellifera L|||Apis mellifera [Honeybee]	Rich	N/A	"1989 Aug;8(8):2387-91. doi: 10.1002/j.1460-2075.1989.tb08368.x.|||EMBO J
. 1989 Aug;8(8):2387-91. doi: 10.1002/j.1460-2075.1989.tb08368.x.|||2676519"	18	
FPDB01467	AP00010|||DRAMP18707	RRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPL	Anti-E. coli ATCC 25922 or ML-35, activity value is MIC = 1 uM||Anti-S. enterica serovar Typhimurium ATCC 14028, activity value is MIC = 1 uM||Anti-S. marcescens ATCC8100, activity value is MIC = 1 uM||Anti-S.aureus ATCC 25923, activity value is MIC > 128 uM||Anti-K. pneumoniae ATCC 13883, activity value is MIC = 12 ug/ml||Anti-E. cloacae ATCC 13047, activity value is MIC = 25 ug/ml||Anti-Gram-||Chemotactic||anti-sepsis||Anti-Escherichia coli ATCC 25922, activity value is MIC = 12 ug/ml||activity value is MIC = 50 ug/ml||Anti-Salmonella typhimurium LT2, activity value is MIC = 12 ug/ml||activity value is MIC = 200 ug/ml||Anti-Salmonella typhimurium ATCC 14028, activity value is MIC = 25 ug/ml||activity value is MIC = 100 ug/ml||Anti-Klebsiella pneumoniae ATCC 13883, activity value is MIC = 12 ug/ml||Anti-Enterobacter cloacae ATCC 13047, activity value is MIC = 25 ug/ml||Anti-Pseudomonas aeruginosa ATCC 7700, activity value is MIC = 50 ug/ml||Anti-##Gram-positive bacterium: Staphylococcus epidermidis ATCC 12228, activity value is MIC = 200 ug/ml	Bovine neutrophils, cattle, Bos taurus|||Bos taurus (Bovine neutrophils)	Rich	No hemolysis information or data found in the reference(s) presented in this entry	"1989 Oct;57(10):3142-6. doi: 10.1128/iai.57.10.3142-3146.1989.|||Infect Immun
. 1989 Oct;57(10):3142-6. doi: 10.1128/iai.57.10.3142-3146.1989.|||Infect Immun. 1989 Oct;57(10): 3142-6.||Ref.2777377"	60	
FPDB01468	AP00027	RRWWRF	Anti-S. aureus, activity value is IC50 = 5 ug/ml||Anti-S. sanguis, activity value is IC50 = 5 ug/ml||Anti-E. coli, activity value is IC50 = 8 ug/ml||Anti-and C. albicans, activity value is IC50 = 39 ug/ml||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis	Synthetic Combinatorial peptide Library, designed, man-made sequences|||Synthetic Combinatorial peptide Library,	Nonhelixbeta	A series of hexapeptides were tested for hemolytic activity on human red blood cells. The results showed that at a concentration of 100 µg/ml, most peptides with significant antibacterial or antifungal activity had hemolysis rates below 5%. Among them, Ac-RRWWCM-NH₂ and Ac-RRWWCW-NH₂ had hemolysis rates of 9.5% and 47–50%, respectively, while other highly active peptides such as Ac-RRWWCF-NH₂ and Ac-RRWWCL-NH₂ had hemolysis rates between 0–5% (detailed data are shown in Table 1).	"1995 Jan;78(1):39-46. doi: 10.1111/j.1365-2672.1995.tb01671.x.|||Comparative Study J Appl Bacteriol
. 1995 Jan;78(1):39-46. doi: 10.1111/j.1365-2672.1995.tb01671.x.|||J Appl Bacteriol. 1992 Dec;73(6):472-9. doi: 10.1111/j.1365-2672.1992.tb05007.x.|||J Appl Bacteriol 1995; 78: 39-46. PubMed."	6	
FPDB01469	AP00102|||AP00102|||OLAP-310|||Thanatin|||DRAMP03057|||Thanatin|||AP00102	GSKKPVPIIYCNRRTGKCQRM	Anti-Gram+ A. viridans, activity value is MIC = 0.6||Anti-M. luteus, activity value is MIC = 1.2||Anti-B. megaterium, activity value is MIC = 2.5||Anti-B. subtilis, activity value is MIC = 2.5||Anti-S-aureus, activity value is MIC > 40 uM||Anti-P. acidolactici, activity value is MIC = 20||Anti-E. coli, activity value is MIC = 0.3||Anti-S. typhimurium, activity value is MIC = 0.6||Anti-K pneumoniae, activity value is MIC = 0.6||Anti-E. cloacae, activity value is MIC = 1.2||Anti-E. carotovora, activity value is MIC = 10||Anti-P. aeruginosa, activity value is MIC = 20||Anti-N. crassa, activity value is MIC = 0.6||Anti-N. crassa, activity value is MIC = 1.2||Anti-N. haematococca, activity value is MIC = 1.2||Anti-T. viride, activity value is MIC = 1.2||Anti-A. brassicola, activity value is MIC = 2.5||Anti-F. culmorum, activity value is MIC = 2.5||Anti-A. pisi, activity value is MIC = 5||Anti-and F. oxysporum, activity value is MIC = 10||MIC E.Coli (ATCC 25922: 8 ug/ml||ATCC 700926: 8 ug/ml||MB 4902: 2 ug/ml)||K. pneumoniae (ATCC 13883: 8 ug/ml||ATCC 700603: 64 ug/ml||BAA 2146: 256 ug/ml)||A. baumannii (ATCC 19606): >256 ug/ml||P. aeruginosa (ATCC 27853): 256 ug/ml||B. subtilis (ATCC 6051): 128 ug/ml||S. aureus ATCC 43300 (MRSA): 256 ug/ml||C. albicans (ATCC 90028): 64 ug/ml||C. neoformans (ATCC 208821): 64 ug/ml||Anti-A. viridans, activity value is MIC = 0.6||Anti-P.acidolactici, activity value is MIC = 20||Anti-E. coli D22, activity value is MIC = 0.3||Anti-E. coli D31, activity value is MIC = 0.3||Anti-E. coli 1106, activity value is MIC = 0.6||Anti-K.pneumoniae, activity value is MIC = 0.6||Anti-E.cloacae, activity value is MIC = 1.2||Anti-E.carotovora, activity value is MIC = 10||Anti-P.aeuroginosa, activity value is MIC = 20||Anti-N.crassa, activity value is MIC = 0.6||Anti-B.cinerea, activity value is MIC = 1.2||Anti-N.haematococca, activity value is MIC = 1.2||Anti-T.viride, activity value is MIC = 1.2||Anti-A.brassicola, activity value is MIC = 2.5||Anti-F.culmorum, activity value is MIC = 2.5||Anti-A.pisi, activity value is MIC = 5||Anti-F.oxysporum, activity value is MIC = 10||Anti-Aerococcus viridans, activity value is MIC = 0.6||Anti-Micrococcus luteus, activity value is MIC = 1.2||Anti-Bacillus megaterium, activity value is MIC = 2.5||Anti-Bacillus subtilis, activity value is MIC = 2.5||Anti-Pediococcus acidilactici, activity value is MIC = 20||Anti-Escherichia coli D22, activity value is MIC = 0.3||Anti-Escherichia coli D31, activity value is MIC = 0.3||Anti-Escherichia coli 1106, activity value is MIC = 0.6||Anti-Salmonella typhimurium, activity value is MIC = 0.6||Anti-Klebsiella pneumoniae, activity value is MIC = 0.6||Anti-Enterobacter cloacae, activity value is MIC = 1.2||Anti-Erwinia carotovora, activity value is MIC = 10||Anti-Pseudomonas aeruginosa, activity value is MIC = 20||Anti-Neurospora crassa, activity value is MIC = 0.6||Anti-Botrytis cinerea, activity value is MIC = 1.2||Anti-Nectria haematococca, activity value is MIC = 1.2||Anti-Trichoderma viride, activity value is MIC = 1.2||Anti-Alternaria brassicicola, activity value is MIC = 2.5||Anti-Fusarium culmorum, activity value is MIC = 2.5||Anti-Ascochyta pisi, activity value is MIC = 5||Anti-Fusarium oxysporum, activity value is MIC = 10	Spined soldier bug, Podisus maculiventris (ALso: peptide conjugates available)|||Spined soldier bug, Podisus maculiventris|||Podisus maculiventris|||Podisus maculiventris [Spined soldier bug]|||Podisus maculiventris|||hemolymph, Spined soldier bug, Podisus maculiventris (ALso: peptide conjugates available)|||Spined soldier bug, Podisus maculiventris (ALso: peptide conjugates available)	Beta||Beta strand	Thanatin at a concentration of 40 μM did not exhibit hemolytic activity against pig red blood cells.	1996 Feb 6;93(3):1221-5. doi: 10.1073/pnas.93.3.1221.|||Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 1.2-2.5 uM), B. megaterium (MIC 2.5-5 uM), B. subtilis (MIC 2.5-5 uM), S-aureus (MIC >40 uM), P. acidolactici (MIC 20-40 uM), Gram- E. coli (MIC 0.3-1.2 uM), S. typhimurium (MIC 0.6-1.2 uM), K pneumoniae (MIC 0.6-1.2 uM), E. cloacae (MIC 1.2-2.5 uM), E. carotovora (MIC 10-20 uM), P. aeruginosa (MIC 20-40 uM), fungi N. crassa (MIC 0.6-1.2 uM), N. crassa (MIC 1.2-2.5 uM), N. haematococca (MIC 1.2-2.5 uM), T. viride (MIC 1.2-2.5 uM), A. brassicola (MIC 2.5-5 uM), F. culmorum (MIC 2.5-5 uM), A. pisi (MIC 5-10 uM), and F. oxysporum (MIC 10-20 uM).|||8577744|||Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.||Ref.8577744|||8577744|||Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-5. doi: 10.1073/pnas.93.3.1221.	21	
FPDB01470	AP00170|||AP00170|||Pyrrhocoricin	VDKGSYLPRPTPPRPIYNRN	Anti-M. luteus, activity value is MIC = 5||Anti-B. megaterium, activity value is MIC = 1||Anti-S-aureus, activity value is MIC > 10 uM||Anti-E. coli D22 or 1106, activity value is MIC = 1||Anti-E cloacae beta12, activity value is MIC = 5||Anti-P. aeruginosa ATCC 82118, activity value is MIC = 5||Antibacterial ; Pyrrhocoris apterus [Sap sucking bug]||Anti-E.coliD22, activity value is MIC = 0.3 uM||Anti-A.tumefaciens, activity value is MIC = 1.25 uM||Anti-S.typhimurium, activity value is MIC = 5 uM	European fire bug Pyrrhocoris apterus|||European fire bug Pyrrhocoris apterus|||Pyrrhocoris apterus [Sap sucking bug]	Nonhelixbeta	M.luteus ( MIC = >80 uM in L.B , P.B), B.megaterium ( MIC = >80 uM in L.B , P.B), E.coliD22 ( MIC = 0.3 uM in L.B, P.B), A.tumefaciens ( MIC = 1.25 uM in LB and 3 uM in PB), S.typhimurium ( MIC = 5 uM in L.B and 10 uM in P.B)	"1994 Jun 1;300 ( Pt 2)(Pt 2):567-75. doi: 10.1042/bj3000567.|||Biochem J
. 1994 Jun 1;300 ( Pt 2)(Pt 2):567-75. doi: 10.1042/bj3000567.|||https://pubmed.ncbi.nlm.nih.gov/10076062"	20	
FPDB01471	AP00172|||AP00172|||Drosocin|||DRAMP03097	GKPRPYSPRPTSHPRPIRV	Anti-F. graminearum, activity value is IC50 = 1 uM||Anti-P. indica and R. solani, activity value is IC50 < 20 uM||Anti-M.luteus, activity value is MIC = 0.5||Anti-E.coli D31, activity value is MIC = 0.5||Antibacterial||Anti-E. coli BL21 RIL, activity value is MIC = 117 uM||No MICs found in DRAMP database	Fruit fly, Drosophila melanogaster|||Fruit fly, Drosophila melanogaster|||Drosophila melanogaster [Fruit fly]|||Drosophila simulans [Fruit fly]|||Drosophila melanogaster (Fruit fly)	Nonhelixbeta||Beta turns	No hemolysis information or data found in the reference(s) presented in this entry	"J Biol Chem
. 1993 Jul 15;268(20):14893-7.|||7588819|||uniprot|||26448548|||Biochemistry. 1999 Jan 12;38(2):705-14.##
J Biol Chem. 1993 Jul 15;268(20):14893-7.##J Biol Chem. 1998 Mar 13;273(11):6139-6143."	19	
FPDB01472	AP00271|||AP00271|||Bactenecin-5	RFRPPIRRPPIRPPFNPPFRPPVRPPFRPPFRPPFRPPIGPFP	Anti-E. coli ML-35p, activity value is MIC < 2.5 ug/ml||Anti-L. monocytogenes EGDP, activity value is MIC < 2.5 ug/ml||Anti-P. aeruginosa, activity value is MIC < 2 ug/ml||Anti-C. albicans, activity value is MIC = 1.5||Antibacterial	Leukocytes, Goat Capra hircus|||Leukocytes, Goat Capra hircus|||Capra hircus [Goat]	Rich	N/A	"1999 Aug;67(8):4106-11. doi: 10.1128/IAI.67.8.4106-4111.1999.|||Infect Immun
. 1999 Aug;67(8):4106-11. doi: 10.1128/IAI.67.8.4106-4111.1999.|||https://pubmed.ncbi.nlm.nih.gov/10417180"	43	
FPDB01473	AP00476|||AP00476|||Pseudin-2|||DRAMP02285|||Pseudin-2|||DRAMP02285	GLNALKKVFQGIHEAIKLINNHVQ	Anti-E. coli, activity value is MIC = 2.5 uM||Anti-S. aureus, activity value is MIC = 80 uM||Anti-C.albicans, activity value is MIC = 130 uM||Antibacterial||Antifungal||Antimicrobial||Anti-Gram+||Anti-Gram-	Paradoxical frog, Pseudis paradoxa, South America|||Paradoxical frog, Pseudis paradoxa, South America|||Pseudis paradoxa [Paradoxical frog]|||Pseudis paradoxa|||Pseudis paradoxa (Paradoxical frog)|||Pseudis paradoxa [Paradoxical frog]|||Pseudis paradoxa (Paradoxical frog)	Helix||Alpha helix	"The 50% hemolytic concentration (HC_{50}) of Pseudin-2 on human red blood cells is >300 µM.|||The document provides the hemolytic value of pseudin-2, as follows:

- HC₅₀ value: Experiments were conducted using red blood cells from 6 healthy donors. The concentration of pseudin-2 that induces 50% hemolysis (HC₅₀) ranges from 320 to 550 µM, and no significant hemolysis was detected at concentrations below 50 µM.

This indicates that pseudin-2 has low hemolytic activity. Its minimum inhibitory concentration (MIC) is 2.6 µM (against E. coli), whereas the concentration that causes hemolysis is much higher, demonstrating a good safety potential.|||L. plantarum WCFS1 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. rhamnosus LGG [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. salivarius DSM20554 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. salivarius FortaFit Ls-33 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. casei R0215 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. casei Shirtota [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. johnsonii LC-1 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. reuteri ATCC5730 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. acidophilus LA5 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. suis S10 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. aureus DMS20231 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. aureus Sens 8325.4 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. aureus MRSA B33424 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. pseudintermedium E138 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. pseudintermedium E139 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. pseudintermedium E140 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. pseudintermedium S70E2 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. pseudintermedium S70E8 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. pseudintermedium S70F3 [MIC = >250 ug/ml] [MBC = >250 ug/ml], P. aeruginosa 26228 [MIC = >256 ug/ml] [MBC = >256 ug/ml], P. aeruginosa 25467 [MIC = >256 ug/ml] [MBC = >256 ug/ml], P. aeruginosa Sens1 PA01 [MIC = >256 ug/ml] [MBC = >256 ug/ml], P. aeruginosa Sens 2 ATCC27853 [MIC = >256 ug/ml] [MBC = >256 ug/ml], P. aeruginosa MDR1 B38084 [MIC = >256 ug/ml] [MBC = >256 ug/ml], P. aeruginosa MDR2 B31770 [MIC = >256 ug/ml] [MBC = >256 ug/ml], E. faecium Sens S1 [MIC = >256 ug/ml] [MBC = >256 ug/ml], E. faecium Sens S2 [MIC = >256 ug/ml] [MBC = >256 ug/ml], E. faecium VanA R39 [MIC = >256 ug/ml] [MBC = >256 ug/ml], E. faecium VanB R44 [MIC = >256 ug/ml] [MBC = >256 ug/ml], A. baumannii MDR Bangl 027 [MIC = >256 ug/ml] [MBC = >256 ug/ml]|||An Antimicrobial Peptide with Low Hemolytic Activity from the Skin of the Paradoxical Frog Loyd Olson III,* Ana Maria Soto,² Floyd C. Knoop,³ and J. Michael Conlon*,1 *Department of Biomedical Sciences and ³Department of Medical Microbiology and Immunology, Creighton University Medical School, Omaha, Nebraska 68178-0405;"	"2001 Nov 9;288(4):1001-5. doi: 10.1006/bbrc.2001.5884.||Abdel-Wahab YH et al., 2008|||Biochem Biophys Res Commun
. 2001 Nov 9;288(4):1001-5. doi: 10.1006/bbrc.2001.5884.||Abdel-Wahab YH et al., 2008|||11689009|||31102497|||Biochem Biophys Res Commun. 2001 Nov 9;288(4):1001-1005.|||11689009|||Biochem Biophys Res Commun. 2001 Nov 9;288(4):1001-1005."	24	
FPDB01474	AP00500|||AP00500|||CPF-AM1|||DRAMP20802	GLGSVLGKALKIGANLL	Anti-Gram+ & Gram-||anti-sepsis||Anti-L. rhamnosus LGG, activity value is MIC = 250 ug/ml||Anti-L. salivarius DSM20554, activity value is MIC = 64 ug/ml||Anti-L. casei R0215, activity value is MIC = 128 ug/ml||Anti-L. casei Shirota, activity value is MIC = 128 ug/ml||Anti-L. johnsonii LC-1, activity value is MIC = 250 ug/ml||Anti-L. reuteri ATCC5730, activity value is MIC = 128 ug/ml||Anti-L. acidophilus LA5, activity value is MIC = 128 ug/ml||Anti-S. aureus DMS20231, activity value is MIC = 128 ug/ml||Anti-S. aureus Sens 8325.4, activity value is MIC = 128 ug/ml||Anti-S. aureus MRSA B33424, activity value is MIC = 32 ug/ml||Anti-S. pseudintermedium E138, activity value is MBC = 32 ug/ml||Anti-P. aeruginosa 25467, activity value is MIC = 256 ug/ml||Anti-P. aeruginosa Sens 2 ATCC27853, activity value is MIC = 32 ug/ml||Anti-P. aeruginosa MDR1 B38084, activity value is MIC = 64 ug/ml||Anti-P. aeruginosa MDR2 B31770, activity value is MIC = 128 ug/ml||Anti-E. faecium Sens S1, activity value is MIC = 32 ug/ml||Anti-E. faecium Sens S2, activity value is MIC = 32 ug/ml||Anti-E. faecium VanA R39, activity value is MIC = 8 ug/ml||Anti-E. faecium VanB R44, activity value is MIC = 16 ug/ml||Anti-A. baumannii MDR Bangl 027, activity value is MIC = 128 ug/ml||Anti-Staphylococcus aureus, activity value is MIC > 200 uM||Anti-##Gram-negative bacteria: Escherichia coli, activity value is MIC > 200 uM	skin secretions, Xenopus amieti, Africa|||skin secretions, Xenopus amieti, Africa|||Xenopus amieti|||Xenopus amieti (skin secretions, Africa)	Alpha helix	"Magainin-AM1, magainin-AM2, and PGLa-AM2 have hemolytic activity (LC_{50}) against human red blood cells >200 µM.|||In the hemolysis assay of antimicrobial peptides from the skin secretions of the octoploid frog Xenopus amieti, the relevant hemolytic values are as follows:

-Magainin-AM1, Magainin-AM2, and PGLa-AM2 exhibit extremely low hemolytic activity, with 50% hemolysis concentrations (LC₅₀) all exceeding 200 µM, and can thus be considered to have no significant hemolytic effect.

Other peptides were not subjected to hemolytic activity assays due to insufficient concentrations or solubility issues. These results indicate that certain peptides exhibit relatively weak hemolytic activity even at higher concentrations, suggesting potential safety.|||[Ref.20226221] LC50>200 uM against human red blood cells"	Peptides. 2010 Jun;31(6):989-94.|||Peptides. 2010 Jun;31(6):989-94.|||20226221|||31102497|||Peptides. 2010 Jun;31(6):989-94.||Ref.20226221	17	
FPDB01475	AP00613|||AP00613|||Fowlicidin 3	RVKRFWPLVPVAINTVAAGINLYKAIRRK	Anti-Gram- E. coli PCN033 or RS218, activity value is MIC = 5||Antibacterial	chicken, Gallus gallus|||chicken, Gallus gallus|||Gallus gallus [Chicken]	Helix	"fowlicidin-{50}) is approximately 6-10 uM.

The 50% hemolytic concentration (EC_{50}) of fowlicidin-2 for human and chicken red blood cells is approximately 15-20 uM."	J Biol Chem. 2006 Feb 3;281(5):2858-67.|||J Biol Chem. 2006 Feb 3;281(5):2858-67.|||17229147	29	
FPDB01476	AP00677|||AP00677|||Neutrophil cationic antibacterial polypeptide of 11000 Da|||DRAMP02984	GLRKKFRKTRKRIQKLGRKIGKTGRKVWKAWREYGQIPYPCRI	Anti-Gram+ & Gram-||Antiviral||anti-sepsis||Antibacterial||Antimicrobial||Anti-Gram+||Anti-Gram-	Guinea pig, Cavia porcellus|||Guinea pig, Cavia porcellus|||Cavia porcellus [Guinea pig]|||Cavia porcellus (Domestic guinea pig)	N/A	N/A	Comp Biochem Physiol B Biochem Mol Biol. 1997 Jan;116(1):99-107|||Comp Biochem Physiol B Biochem Mol Biol. 1997 Jan;116(1):99-107|||8644997|||Arch Biochem Biophys. 1996 Apr 15;328(2):219-226.	43	
FPDB01477	AP00678|||AP00678|||Cathelicidin|||DRAMP02925|||Cathelicidin|||AP00678	RLKELITTGGQKIGEKIRRIGQRIKDFFKNLQPREEKS	"Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis||anti-sepsis
Crucial residues:||Antibacterial||Anti-Escherichia coli, activity value is MIC = 1.25 uM||Anti-Klebsiella pneumoniae, activity value is MIC = 1.25 uM||Anti-Salmonella serotype Typhimurium, activity value is MIC = 1.25 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 1.25 uM||Anti-Proteus mirabilis, activity value is MIC = 1.25 uM||Anti-Salmonella serotype Enteritidis, activity value is MIC = 0.5 uM||Anti-Neisseria gonorrhoeae, activity value is MIC = 0.06 uM||Anti-Staphylococcus aureus, activity value is MIC = 50 uM||Anti-Candida albicans ATCC 11006, activity value is MIC = 44.33 uM||Anti-Candida albicans ATCC 14053, activity value is MIC = 11.08 uM||Anti-Escherichia coli ATCC 25922, activity value is MIC = 1.11 uM||Anti-Escherichia coli ATCC 700336, activity value is MIC = 1.11 uM||Anti-Escherichia coli ATCC 700378, activity value is MIC = 1.11 uM||Anti-Escherichia coli ATCC BAA-457, activity value is MIC = 1.11 uM||Anti-Klebsiella pneumoniae ATCC 10031, activity value is MIC = 1.11 uM||Anti-Proteus mirabilis ATCC 12453, activity value is MIC = 1.11 uM||Anti-Pseudomonas aeruginosa ATCC 10145, activity value is MIC = 1.11 uM||Anti-Salmonella Enteritidis ATCC 13076, activity value is MIC = 0.44 uM||Anti-Salmonella Typhimurium ATCC 13311, activity value is MIC = 1.11 uM||Anti-Neisseria gonorrhoeae ATCC 10150, activity value is MIC = 0.06 uM||Anti-Staphylococcus aureus ATCC 10832, activity value is MIC = 44.33 uM||Anti-Listeria monocytogenes ATCC 19115, activity value is MIC = 0.44 uM||Anti-Ureaplasma canigenitalium ATCC 51252, activity value is MIC = 0.06 uM||Anti-Ureaplasma urealyticum ATCC 27619, activity value is MIC = 44.33 uM"	Dog|||Dog|||Canis lupus familiaris [Dog]|||Canis lupus familiaris (Dog)|||Canis lupus familiaris [Dog]|||Dog	N/A	At a concentration of 100 μM, K9CATH caused less than 5% hemolysis of human, dog, and chicken red blood cells. By comparison, the bovine-derived cathelicidin fragment BMAP-28 (1-18) caused approximately 20%, 25%, and 30% hemolysis of chicken, dog, and human red blood cells, respectively, at the same concentration.|||The document mentions that K9CATH, at concentrations up to 100 μM, causes less than 5% hemolysis in dog, human, and chicken red blood cells, showing extremely low hemolytic activity. In contrast, the positive control, bovine bone marrow antimicrobial peptide BMAP-28 (1-18), at 100 μM, causes approximately 20%, 25%, and 30% hemolysis in chicken, dog, and human red blood cells, respectively.|||K9CATH exhibits very low hemolytic activity against human, canine, and chicken red blood cells, with hemolysis rates of less than 5% at a concentration of 100 μM. The positive control, bovine bone marrow antimicrobial peptide BMAP-28 (1-18), at 100 μM, shows hemolysis rates of approximately 20%, 25%, and 30% against chicken, canine, and human red blood cells, respectively. Compared to BMAP-28, K9CATH has 10-20 times lower in vitro hemolytic activity against canine and chicken red blood cells.	Dev Comp Immunol 2007; 31:1278-96.|||Dev Comp Immunol 2007; 31:1278-96.|||17462733|||Dev Comp Immunol. 2007;31(12):1278-1296.|||17462733|||Dev Comp Immunol 2007; 31:1278-96.	38	
FPDB01478	AP00681|||DRAMP02915	RFRPPIRRPPIRPPFRPPFRPPVRPPIRPPFRPPFRPPIGPFP	Anti-ctive against E. coli 0157:H7, activity value is MIC = 4 ug/ml||Anti-S. aureus 1056 MRSA, activity value is MIC = 10 ug/ml||Anti-and C. albicans 3153A, activity value is MIC = 10 ug/ml||Anti-E. coli 0157:H7, activity value is MIC = 4 ug/ml||Antimicrobial	Sheep neutrophil extract, Ovis aries|||Ovis aries (Sheep)	Rich	N/A	"2003 Dec 26;312(4):1139-46. doi: 10.1016/j.bbrc.2003.11.045.|||Biochem Biophys Res Commun
. 2003 Dec 26;312(4):1139-46. doi: 10.1016/j.bbrc.2003.11.045.|||J Nutr. 1998 Feb;128(2 Suppl):297S-299S.Gene. 1998 Jan 5;206(1):85-91."	43	
FPDB01479	AP00683	RRLRPRRPRLPRPRPRPRPRPRSLPLPRPQPRRIPRPILLPWRPPRPIPRPQIQPIPRWL	Anti-Gram+ & Gram-||anti-sepsis	Sheep. Ovis aries	Rich	N/A	"2003 Dec 26;312(4):1139-46. doi: 10.1016/j.bbrc.2003.11.045.|||Biochem Biophys Res Commun
. 2003 Dec 26;312(4):1139-46. doi: 10.1016/j.bbrc.2003.11.045."	60	
FPDB01480	AP00945|||AP00945|||OP-145	IGKEFKRIVERIKRFLRELVRPLR	Anti-24 h incubation: Active against E. coli ATCC 8739, activity value is MIC = 2 uM||Anti-P. aeruginosa ATCC 9027, activity value is MIC = 3 uM||Anti-C. albicans ATCC 10231, activity value is MIC = 6 uM||Anti-and A. niger ATCC 14406, activity value is MIC = 18 uM||Antibacterial||Antibiofilm||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis	peptide library screen, human cathelicidin analog, animal-derived, natural derivative|||peptide library screen, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct	N/A	N/A	2006 Apr;27(4):649-60. doi: 10.1016/j.peptides.2005.09.016. Epub 2005 Nov 7.||see ref|||2006 Apr;27(4):649-60. doi: 10.1016/j.peptides.2005.09.016. Epub 2005 Nov 7.||see ref|||26525663, 28890511|||Peptides. 2006 Apr;27(4):649-60. doi: 10.1016/j.peptides.2005.09.016. PubMed.|||Peptides. 2006 Apr;27(4):649-60. doi: 10.1016/j.peptides.2005.09.016. PubMed.||see ref	24	
FPDB01481	AP01132|||TCP-25	GKYGFYTHVFRLKKWIQKVIDQFGE	XX||Pseudomonas aeruginosa||Staphylococcus aureus; [Refer PubMed ID - 33808488: Escherichia coli BW25113 (MIC = >200 ug/ml)]	in human wound fluid and fibrin|||Homo sapiens [Human]	Helix	At concentrations of 60-120 uM, GKY25 has no significant permeabilizing effect on human red blood cells (low hemolysis rate).|||Sheep RBC, 70% hemolysis at 200 ug/ml	2010 Apr 22;6(4):e1000857. doi: 10.1371/journal.ppat.1000857.|||33951491, 33808488	25	
FPDB01482	AP01475	ECWMDGHCRLLCKDGEDSIIRCRNRKRCC	Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis	pooled fetal lung, testis, B-cell, Homo sapiens|||pooled fetal lung, testis, B-cell, Homo sapiens	Bridge	"The document mentions the following values related to hemolysis: 
 DEFB120: At concentrations up to 250 μg/ml, the hemolysis rate of human red blood cells is less than 10%, showing no significant hemolytic activity. 
 LL37 (positive control): At a concentration of 250 μg/ml, the hemolysis rate of human red blood cells is approximately 35%.|||Many antimicrobial peptides (AMPs) tend to have cytotoxicity. Therefore, it is expected to detect cytotoxic and hemolytic activities of DEFBs working as ideal candidates against pathogenic microorganisms. To evaluate the hemolytic effect of the recombinant DEFB120 peptide, the released hemoglobin from erythrocytes was tested. Erythrocytes were incubated with different concentrations of the DEFB120 peptide in the range of 10–250 ug/ml for 1h at 37 °C. As a positive control, LL37 was tested in the same way. Under these conditions, LL37 exhibited prominent hemolytic activity with concentration dependence, whereas DEFB120 showed no significant hemolytic effect up to 250 ug/ml (Figure 7)."	2014 Apr;20(4):251-7. doi: 10.1002/psc.2611. Epub 2014 Jan 21.|||J Pept Sci. 2014 Apr;20(4):251-7. Pub-Med.	29	
FPDB01483	AP01520|||AP01520|||Ls-Stylicin1|||DRAMP04592	SSFSPPRGPPGWGPPCVQQPCPKCPYDDYKCPTCDKFPECEECPHISIGCECGYFSCECPKPVCEPCESPIAELIKKGGYKG	Anti-This peptide showed weak activity, activity value is MIC = 40||Anti-and strong activity against pathogenic fungus Fusarium oxysporum, activity value is MIC = 2.5 uM||Anti-Fusarium oxysporum, activity value is MIC = 1.25||Anti-Vibrio penaeicidae, activity value is MIC = 40||Anti-Vibrio nigripulchritudo, activity value is MIC = 40||No MICs found in DRAMP database	Litopenaeus stylirostris|||Litopenaeus stylirostris|||Litopenaeus stylirostris [Pacific blue shrimp]	N/A	No hemolysis information or data found in the reference(s) presented in this entry	Mol Immunol. 2010; 47: 1269-1277.|||Mol Immunol. 2010; 47: 1269-1277.|||20061030|||Mol Immunol. 2010 Mar;47(6):1269-1277.	82	
FPDB01484	AP01550|||AP01550|||Dybowskin-2CDYa|||DRAMP01255	SAVGRHGRRFGLRKHRKH	Anti-trongly active against S. aureus ATCC12600, activity value is MIC = 6 uM||Anti-Strongly active against S. aureus ATCC12600, activity value is MIC = 6 uM||Anti-E.coli, activity value is MIC = 3 uM||Anti-S.aureus, activity value is MIC = 6 uM||Anti-Escherichia coli, activity value is MIC = 3 uM||Anti-Staphylococcus aureus, activity value is MIC = 6 uM||Anti-Bacillus cereus, activity value is MIC = 14.4 uM||Anti-Streptococcus lactis, activity value is MIC = 14.4 uM	skin secretion, the Chinese brown frog, Rana dybowskii; Rana chensinensis, China, Asia|||skin secretion, the Chinese brown frog, Rana dybowskii; Rana chensinensis, China, Asia|||Rana dybowskii [Korean brown frog]|||Rana dybowskii (Dybovsky's frog) (Korean brown frog)	N/A	The half-maximal hemolytic concentration (HC_{50}) of brevinin-1CDYa is 125 µM; the HC_{50} of Japonicin-1CDYa is greater than 300 µM; the HC_{50} of Temporin-CDYb is 180 µM; the HC_{50} of Dybowskin-1CDYa is greater than 300 µM; and the HC_{50} of Dybowskin-2CDYa is greater than 300 µM.|||Human red blood cells (HC50 = >300 uM)|||[Ref:19539775]HC50>300 uM against human red blood cells	Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-8|||Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-8|||19539775|||Ref.19539775||Ref.19341344	18	
FPDB01485	AP01575	NLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF	Radial diffusion assay: active against E. coli ATCC 25922 and P. aeruginosa ATCC 27852.	wound, Homo sapiens	Helix	N/A	PLoS Pathog. 2010 Apr 22;6(4):e1000857	94	
FPDB01486	AP01623|||AP01623|||Limulus clotting factor C|||DRAMP04252	GFKLKGMARISCLPNGQWSNFPPKCIRECAMVSS	Anti-Gram-||anti-sepsis||Antibacterial||Antimicrobial	Protein-derived peptide, Sequence truncation|||Protein-derived peptide, Sequence truncation|||Synthetic construct|||Synthetic construct	Helix	Human erythrocytes (0% hemolysis at 100 ug/ml)	FASEB J. 2000 Sep;14(12):1801-13|||FASEB J. 2000 Sep;14(12):1801-13|||11557475, 30279591|||FASEB J. 2000 Sep;14(12):1801-1813.	34	
FPDB01487	AP01624|||AP01624|||Undefined|||DRAMP04253	HAEHKVKIGVEQKYGQFPQGTEVTYTCSGNYFLM	Anti-Gram-||anti-sepsis||Antibacterial||Antimicrobial	Protein-derived peptide, Sequence truncation|||Protein-derived peptide, Sequence truncation|||Synthetic construct|||Synthetic construct	N/A	Human erythrocytes (8% Hemolysis at 100 ug/ml	FASEB J. 2000 Sep;14(12):1801-13|||FASEB J. 2000 Sep;14(12):1801-13|||11557475|||FASEB J. 2000 Sep;14(12):1801-1813.	34	
FPDB01488	AP01625|||DRAMP03357	LQDAALGWGRRCPQCPRCPSCPSCPRCPRCPRCKCNPK	Anti-Gram-||anti-sepsis||Anti-Gram+ & Gram-||bacteria-agglutinating AMPs||Antimicrobial||Antibacterial||Anti-Gram+	intestine, Mus musculus|||Mus musculus (Mouse)	N/A	N/A	"2004 Aug;5(8):836-43. doi: 10.1038/ni1094. Epub 2004 Jul 4.|||Nat Immunol
. 2004 Aug;5(8):836-43. doi: 10.1038/ni1094. Epub 2004 Jul 4.|||Nat Immunol. 2004 Aug;5(8):836-843."	38	
FPDB01489	AP01626|||DRAMP03358	LQDAAVGWGRRCPQCPRCPSCPSCPRCPRCPRCKCNPK	Anti-Gram-||anti-sepsis||Anti-Gram+ & Gram-||bacteria-agglutinating AMPs||Antimicrobial||Antibacterial||Anti-Gram+	intestine, Mus musculus|||intestine, Mus musculus|||Mus musculus (Mouse)	N/A	N/A	"2004 Aug;5(8):836-43. doi: 10.1038/ni1094. Epub 2004 Jul 4.|||Nat Immunol
. 2004 Aug;5(8):836-43. doi: 10.1038/ni1094. Epub 2004 Jul 4.|||Nat Immunol. 2004 Aug;5(8):836-843."	38	
FPDB01490	AP01627|||AP01628|||AP01629|||AP01630|||AP01631|||AP01628|||DRAMP03360	LQDAALGWGRRCPRCPPCPRCSWCPRCPTCPGCNCNPK	Anti-Gram-||anti-sepsis||Anti-Gram+ & Gram-||bacteria-agglutinating AMPs||Antimicrobial||Antibacterial||Anti-Gram+	intestine, Mus musculus|||intestine, Mus musculus|||Mus musculus (Mouse)	N/A	N/A	"2004 Aug;5(8):836-43. doi: 10.1038/ni1094. Epub 2004 Jul 4.|||Nat Immunol
. 2004 Aug;5(8):836-43. doi: 10.1038/ni1094. Epub 2004 Jul 4.|||Nat Immunol. 2004 Aug;5(8):836-843."	38	
FPDB01491	AP01751|||Papiliocin|||AP01751|||DRAMP04577	RWKIFKKIEKVGRNVRDGIIKAGPAVAVVGQAATVVK	Anti-it is especially active against Gram-negative bacteria. Active against Gram- E. coli, activity value is MIC = 0.25 uM||Anti-S. typhimurium, activity value is MIC = 0.5 uM||Anti-P. aeruginosa, activity value is MIC = 1.0 um||Anti-S. aureus, activity value is MIC = 32 uM||Anti-B. subtilis, activity value is MIC = 16 uM||Anti-and S. epidermidis, activity value is MIC = 2 uM||Antibacterial||Antifungal||No MICs found in DRAMP database||Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis	the swallowtail butterfly, Papilio xuthus|||the swallowtail butterfly, Papilio xuthus|||Papilio xuthus [Asian swallowtail butterfly]|||the swallowtail butterfly, Papilio xuthus|||Papilio xuthus	Helix	"At concentrations of 50 μM, 25 μM, 12.5 μM, 6.25 μM, and 3.13 μM, the hemolysis rate of human red blood cells by Papiliocin was 0%.|||Researchers conducted hemolytic activity assays on human red blood cells using synthetic papiliocin, with melittin from bee venom serving as a positive control. At different concentrations, the hemolysis rates of the two peptides are as follows:

-Papiliocin: At concentrations of 50 µM, 25 µM, 12.5 µM, 6.25 µM, and 3.13 µM, the hemolysis rate was 0% in all cases.

-Melittin: At concentrations of 50 µM, 25 µM, 12.5 µM, and 6.25 µM, the hemolysis rate was 100% in each case; at a concentration of 3.13 µM, the hemolysis rate was 98%.|||No hemolysis information or data found in the reference(s) presented in this entry|||Not hemo.lytic at 100 uM"	"2010 Apr;29(4):419-23. doi: 10.1007/s10059-010-0050-y. Epub 2010 Mar 4|||Mol Cells
. 2010 Apr;29(4):419-23. doi: 10.1007/s10059-010-0050-y. Epub 2010 Mar 4.|||20213310|||Mol Cells. 2010 Apr;29(4):419-23. PubMed|||Mol Cells. 2010 Apr;29(4):419-423.|||Mol Cells. 2010 Apr;29(4):419-23. PubMed"	37	
FPDB01492	AP02099	RPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCTY	Has ribonuclease activity. Active against parasites  . 0.5 uM rhECP reduced infectivity of extracellular virions of the single-stranded RNA virus||respiratory syncytial virus||group B (RSV-B) approximately 6 fold  . Also active against M. vaccae  . It binds to LPS. RNase 3 has a unique bacteria-agglutinating activity.	eosinophilic leukocytes, Homo sapiens	COMBINE HELIX AND BETA STRUCTURE	N/A	1990 Apr 15;144(8):3166-73.||see the ref||Domachowske JB et al. 1998||Boix E et al., 2008	98	
FPDB01493	AP02138|||AP02140|||AP02138|||Oreoch-1|||Oreoch-1|||AP02138|||AP02138	FIHHIIGGLFSVGKHIHGLIHGH	Anti-S. aureus, activity value is MIC = 5 uM||Anti-B. subtilis, activity value is MIC = 3 uM||Antibacterial||Antifungal||Anti-Gram+ & Gram-||candidacidal||anti-sepsis	gills, tilapia, Oreochromis niloticus|||Oreochromis niloticus [Nile tilapia]	N/A	"TP1 and TP5 showed no hemolytic activity at a concentration of 100 µg/ml. TP2 had a hemolysis rate of 60% at a concentration of 40 µg/ml. TP3 had a hemolysis rate of 42% at a concentration of 100 µg/ml. TP4 had a hemolysis rate of 100% at a concentration of 100 µg/ml.|||gills, tilapia, Oreochromis niloticus||HC₅₀ = 10 uM。|||Synthetic piscidin-like peptides were assays for hemolytic activity in
human and fish red blood cells. Oreoch-1 and Oreoch-3 were not hemo-
lytic forhuman red blood cells at concentrations below55 uM. Incontrast,
Oreoch-2 was hemolytic in human erythrocytes reaching 50% ofhemoly-
sis at 19 uM(Fig. 7A). In addition, hemolytic activity in fish red blood cells
was observed for Oreoch-1 and Oreoch-2 above 16 uMand 7 uMrespec-
tively, in a dose-dependent manner. Oreoch-1 and Oreoch-2 reached 23%
and 57% ofhemolysis, respectively, at the highest concentration analyzed
(Fig. 7B). In contrast, Oreoch-3 was not hemolytic for fish erythrocytes at
concentrations below 55 uM(Fig. 7B)."	2012;7(11):e50263. doi: 10.1371/journal.pone.0050263. Epub 2012 Nov 30.|||Aquaculture 2013; 372–375;9–18.|||Reference: Acostaa J, Monterob V, Carpioa Y, Velázqueza J, Garayc HE, Reyesc O, Cabralesc A, Masforrolc Y, Moralesa A, Estrada MP (2013) Cloning and functional characterization of three novel antimicrobial peptides from tilapia (Oreochromis niloticus). A|||Reference: Acostaa J, Monterob V, Carpioa Y, Velázqueza J, Garayc HE, Reyesc O, Cabralesc A, Masforrolc Y, Moralesa A, Estrada MP (2013) Cloning and functional characterization of three novel antimicrobial peptides from tilapia (Oreochromis niloticus). A|||Aquaculture 2013; 372–375;9–18. Sci Direct.|||Aquaculture 2013; 372–375;9–18. Sci Direct.	23	
FPDB01494	AP02182|||AP02182|||Beta-defensin114|||DRAMP03613	DRCTKRYGRCKRDCLESEKQIDICSLPRKICCTEKLYEEDDMF	Active against E. coli||S. aureus||and C. albicans. Activity is salt-sensitive. In addition||this human beta defensin protects sperm from motility loss.||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis||Antibacterial||Antimicrobial	epididymis and gingival cells , Homo sapiens|||Homo sapiens  [Human]|||epididymis and gingival cells , Homo sapiens|||Homo sapiens (Human)	Bridge	epididymis and gingival cells , Homo sapiens||DEFB114 has no obvious hemolytic effect on human red blood cells at a concentration of 100 ug/ml.	"Vet. Immunol. Immunopathol. 106 (3-4), 321-327 (2005)|||J Biol Chem. 2013 Apr 26;288(17):12270-82. Pub-Med.|||85540943|||J Biol Chem
. 2013 Apr 26;288(17):12270-82. doi: 10.1074/jbc.M112.411884. Epub 2013 Mar 12.|||Physiol Genomics. 2005 Sep 21;23(1):5-17.Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2129-33.|||J Biol Chem. 2013 Apr 26;288(17):12270-82. Pub-Med."	43	
FPDB01495	AP02202|||DRAMP18489	RKCNFLCKLKEKLRTVITSHIDKVLRPQG	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory||anti-sepsis||Anti-Staphylococcus aureus ATCC 2592, activity value is MIC = 2.74 uM	Skin secretions; frog, Paa yunnanensis, Yunnan, China, Asia|||Paa yunnanensis(Chinese Yunnan frog)	Helix	At concentrations of 12.5 µg/mL, 25 µg/mL, and 50 µg/mL, the hemolysis rates in human red blood cells were 2.5%, 3.5%, and 5.5%, respectively.|||Skin secretions; frog, Paa yunnanensis, Yunnan, China, Asia||At a concentration of 12.5 ug/ml, it induces 2.5% hemolysis of human red blood cells; at 25 ug/ml, the hemolysis rate is 3.5%; and at 50 ug/ml, it is 5.5%.|||[Ref.23594231]2.5% hemolytic activity at 12.5 ug/ml, 3.5 hemolytic activity at 25 ug/ml, 5.5% hemolytic activity at 50 ug/ml against human red blood cells	"2013 May 9;56(9):3546-56. doi: 10.1021/jm4004158. Epub 2013 Apr 29.|||J Med Chem. 2013 May 9;56(9):3546-56. Pub-Med.|||J Med Chem
. 2013 May 9;56(9):3546-56. doi: 10.1021/jm4004158. Epub 2013 Apr 29.|||Ref.23594231|||J Med Chem. 2013 May 9;56(9):3546-56.||Ref.23594231"	29	
FPDB01496	AP02204	KTKKKLLKKT	Anti-active agianst Gram- bacteria A. baumannii or 18 Acinetobacter spp. isolates, activity value is MIC = 50||Anti-13 E. coli strains, activity value is MIC = 50||Anti-8 Enterobacter spp. isolates, activity value is MIC = 50||Anti-16 K. pneumoniae strains, activity value is MIC = 50||Anti-33 P. aeruginosa strains, activity value is MIC = 50||Anti-17 S.maltophilia strains, activity value is MIC = 50||Anti-Gram-||anti-sepsis||Synergistic AMPs||Antibiofilm	Paenibacillus polymyxa var. colistinus; Also known as Bacillus polymyxa	Nonhelixbeta	"Paenibacillus polymyxa var. colistinus; Also known as Bacillus polymyxa|||The document contains limited information regarding the hemolytic properties of polymyxins and related substances. It does not specify exact hemolysis rates, but includes the following qualitative descriptions related to hemolytic activity:

1. Hemolytic behavior of polymyxin

On blood agar plates, Bacillus polymyxa colonies producing polymyxins display very narrow but distinct hemolytic rings around them, though the exact hemolysis rates corresponding to these rings have not been measured. Experiments using media containing different concentrations of defibrinated rabbit blood (10%, 20%, 50%) confirmed that within the experimental range of polymyxin concentrations tested (maximum 32,000 µg/100 ml, minimum 1/256 dilution), polymyxin did not cause visible hemolysis, exhibiting only antibacterial activity (inhibiting the growth of Escherichia coli).

2. Comparison of hemolysis of Bacillus polymyxa cell extracts

A substance extracted from Bacillus polymyxa cells (poorly water-soluble, soluble in ethanol) did not have its hemolysis directly measured. However, this substance shows antibacterial activity against Staphylococcus aureus (inhibition at a concentration of 10 µg/ml), has no activity against Escherichia coli, and its properties resemble those of tyrothricin. Tyrothricin is known to show clear hemolytic activity, which can serve as a reference for comparison, but the specific hemolysis rate of this cell extract itself is not mentioned.

3. Hemolysis comparison with other antibiotics (to distinguish polymyxin)

Tyrothricin: shows clear hemolytic activity, distinguishing it from polymyxin, which shows no visible hemolysis.
Gramicidin S: has hemolytic activity, which differs from the hemolytic behavior of polymyxin."	1947 Jul;81(1):43-54|||Bull Johns Hopkins Hosp. 1947 Jul;81(1):43-54. Pub-Med.	10	
FPDB01497	AP02221|||AP02221|||Mini-ChBac7.5N beta|||DRAMP20787|||Mini-ChBac7.5N beta|||DRAMP20787	RRLRPRRPRLPRPRPRPRPRP	Anti-Gram+ & Gram-||anti-sepsis||Anti-or M17, activity value is MIC = 1||Anti-clincla strains, activity value is MIC = 2 uM||Anti-Klebsiella spp. clinical isolate, activity value is MIC = 4 uM||Anti-A. baumannii clinical isolate, activity value is MIC = 4 uM||Anti-L. monocytogenes EGD, activity value is MIC = 2 uM||Anti-M. luteus CIP A270, activity value is MIC = 1 uM||Anti-S-aureus ATCC 25923 or 710A or MRSA, activity value is MIC > 64 uM||Anti-S-intermedius clin. isolate, activity value is MIC > 64 uM||Anti-C-albicans 820, activity value is MIC > 64 uM||Anti-and C-parapsilosis, activity value is MIC > 64 uM||Antibacterial||Antifungal||Anti-E.coli, activity value is MIC = 0.3||activity value is MIC = 1.4||activity value is MIC = 1 uM||Anti-E.coli, activity value is MIC = 0.5||activity value is MIC = 0.8||activity value is MIC = 2 uM||activity value is MIC = 0.9||Anti-Pseudomonas aeruginosa, activity value is MIC = 1||activity value is MIC = 3.2||Anti-Pseudomonas aeruginosa clinical isolate, activity value is MIC = 2 uM||Anti-Acinetobacter baumannii clinical isolate, activity value is MIC = 4 uM||Anti-Listeria monocytogenes, activity value is MIC = 0.2||Anti-Micrococcus luteus CIP A270, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 0.6||activity value is MIC > 50 uM||activity value is MIC > 64 uM||Anti-Staphylococcus aureus, activity value is MIC > 64 uM||Anti-MRSA, activity value is MIC = 0.5||Anti-Staphylococcus intermedius clin. isolate, activity value is MIC > 64 uM||Anti-Candida albicans, activity value is MIC = 0.3||activity value is MIC = 64 uM||Anti-Candida parapsilosis clinical isolate, activity value is MIC > 64 uM||Anti-E.coli ML35p, activity value is MIC = 1||Anti-E.coli ATCC 25922, activity value is MIC = 2 uM||Anti-E.coli M17, activity value is MIC = 1 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 2 uM||Anti-Acinetobacter baumannii clinical isolate, activity value is MIC = 4||Anti-Listeria monocytogenes EGD, activity value is MIC = 2 uM||Anti-##Gram-positive bacteria:Listeria monocytogenes, activity value is MIC = 0.2||Anti-##Fungi:Candida albicans, activity value is MIC = 0.3	neutrophils, domestic goat, Capra hircus|||Capra hircus [Goat]|||Capra hircus	Rich	neutrophils, domestic goat, Capra hircus||In the concentration range of 1–100 uM, mini-ChBac7.5Nβ has no obvious hemolytic effect on human red blood cells.|||E.coli ML35p(MIC=1micoM) , E.coli ATCC 25922(MIC=2 uM), E.coli M17(MIC=1 uM), Pseudomonas aeruginosa ATCC 27853(MIC=2 uM), Pseudomonas aeruginosa clinical isolate(MIC=2 uM), Klebsiella spp. clinical isolate(MIC=4 uM), Acinetobacter baumannii clinical isolate(MIC=4microm), Listeria monocytogenes EGD(MIC=2 uM),Micrococcus luteus CIP A270(MIC=1 uM), Staphylococcus aureus 710A(MIC=>64 uM), Staphylococcus aureus ATCC 25923(MIC=>64 uM), MRSA ATCC 33591(MIC=>64 uM), Staphylococcus intermedius clin. isolate(MIC=>64 uM), Candida albicans 820(MIC=>64 uM), Candida parapsilosis clinical isolate(MIC=>64 uM)|||No hemolytic activity against human erythrocytes|||[Ref.27818338] No hemolytic activity	2016 Jul-Sep;8(3):136-146.|||Acta Naturae. 2016 Jul-Sep;8(3):136-146. Pub-Med.|||27795854|||Acta Naturae. 2016 Jul-Sep;8(3):136-146.||Ref.27795854|||27795854|||Acta Naturae. 2016 Jul-Sep;8(3):136-146.||Ref.27795854	21	
FPDB01498	AP02241	KYALMKKIAELIPNLKSRQVK	Anti-Gram+ & Gram-||Antifungal||candidacidal	centipede, Scolopendra subspinipes mutilans, Asia	N/A	centipede, Scolopendra subspinipes mutilans, Asia||Within the concentration range (0–320 ug/ml), there is no obvious hemolytic effect on rat red blood cells, and the hemolysis rate remains 0%.	"2013 Oct 28;23(10):1381-5. doi: 10.4014/jmb.1306.06013.|||J Microbiol Biotechnol. 2013 Oct 28;23(10):1381-5. Pub-Med.|||J Microbiol Biotechnol
. 2013 Oct 28;23(10):1381-5. doi: 10.4014/jmb.1306.06013."	21	
FPDB01499	AP02259	QYEALVASILGKLSGLWHSDTVDFMGHTCHIRRRPKFRKFKLYHEGKFWCPGWTHLEGNSRTKSRSGSARDAIKDFVYKALQNKLITENNAAAW	Anti-recombinant SsALF showed some activity against Gram- E. coli, activity value is MIC = 50||Anti-P. aeruginosa, activity value is MIC = 25||Anti-S.aureus, activity value is MIC > 200 ug/ml||Anti-and S.pyogenes, activity value is MIC = 100	hemocytes, heart and muscle, Indian mud crab, Scylla serrata	Nonhelixbeta	N/A	2009 Aug;27(2):275-84. doi: 10.1016/j.fsi.2009.05.009. Epub 2009 May 31.	94	
FPDB01500	AP02442	QVLEGLAAAVTGKLAGLWRNGEVELLGHYCSYSVTPTIRRWQLYFRGRMWCPGWTSIRGEAMTRSNSGVQGDTTRDFVTKALNAGLISQQEAQ	Active against G+ bacteria S. aureus||B. subtilis||B. cereus||B. thuringiensis||and B. megaterium||G- bacteria E. coli and P. aeruginosa||including V. anguillarum||and fungi C. albicans. Recombinant PcALF1 can clear fish pathogen V. anguillarum.	red swamp crayfish, Procambarus clarkii	N/A	N/A	2011 Jan;30(1):295-303. doi: 10.1016/j.fsi.2010.10.022. Epub 2010 Nov 4.	93	
FPDB01501	AP02443	NIFDDIFGKVTETLVDFGTTDIAGNPCNYRLSPRLIKFELYFVGLVWCPGWTTIQGESLTRSRTRVVNKAVEDFAKKAVAAGIMTQEDADPLLNA	Active against G- bacterium L. anguillarum and antifungal activity against P. pastoris||but not active against M.luteus and S.aureus. A conserved disulfide bond is predicted between Cys27 and Cys48.	gill (high expression); haemocytes, hepatopancreas and muscle (moderate expression), Chinese mitten crab, Eriocheir sinensis	N/A	gill (high expression); haemocytes, hepatopancreas and muscle (moderate expression), Chinese mitten crab, Eriocheir sinensis	"2010 Sep;34(9):945-52. doi: 10.1016/j.dci.2010.04.002. Epub 2010 Apr 28|||Dev Comp Immunol. 2010 Sep;34(9):945-52. PubMed|||Dev Comp Immunol
. 2010 Sep;34(9):945-52. doi: 10.1016/j.dci.2010.04.002. Epub 2010 Apr 28"	95	
FPDB01502	AP02444	GWLDRIIGTAVDSVAEFGTTNIVDQICNTRVMPTIKKFELYFRGRVWCPGWTTIQGESLTRSRTRVVNKAVEDFARKAVAAGLMTQEDANPLLNA	Anti-and Gram+ bacteria M. luteus, activity value is MBC = 6.9 uM	haemocytes, heart and gonad, Chinese mitten crab, Eriocheir sinensis	N/A	haemocytes, heart and gonad, Chinese mitten crab, Eriocheir sinensis	2008;32(7):784-94. doi: 10.1016/j.dci.2007.11.008. Epub 2007 Dec 26.|||Dev Comp Immunol. 2008;32(7):784-94. PubMed	95	
FPDB01503	AP02569|||AP02569|||Hc-CATH|||DRAMP29102|||Hc-CATH|||AP02569|||DRAMP29102	KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL	Anti-E. coli ATCC25922, activity value is MIC = 0.64 uM||Anti-K. oxytoca, activity value is MIC = 1.3 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 5.2||Anti-E. tarda, activity value is MIC = 0.64 uM||activity value is MIC = 1.3||Anti-and V. anguillarum . This peptide also showed good activity against aquatic bacteria Gram- V. alginolyticus, activity value is MIC = 2.59 uM||Anti-V. brasiliensis, activity value is MIC = 1.29 uM||Anti-V. cholerae, activity value is MIC = 0.64 uM||Anti-V. harveyi, activity value is MIC = 1.29 uM||Anti-V. parahaemolyticus, activity value is MIC = 0.64 uM||Anti-V. splendidus, activity value is MIC = 1.29 uM||Anti-V. vulnificus, activity value is MIC = 2.59 uM||Anti-A. hydrophila, activity value is MIC = 1.29 uM||Anti-A. sobria, activity value is MIC = 2.59 uM||Anti-A.veronii, activity value is MIC = 2.59 uM||Anti-and N. asteroides, activity value is MIC = 1.29||Anti-E. coli ATCC25922, activity value is MIC = 2.34 ug/ml||Anti-E. coli 1 Clinically isolated strain, activity value is MIC = 2.34 ug/ml||Anti-E. coli 2, activity value is MIC = 2.34 ug/ml||Anti-E. coli 3, activity value is MIC = 2.34 ug/ml||Anti-E. coli 4, activity value is MIC = 2.34 ug/ml||Anti-S. dysenteriae, activity value is MIC = 0.59 ug/ml||Anti-P. aeruginosa ATCC27853, activity value is MIC = 18.75 ug/ml||Anti-Staphylococcus aureus ATCC25923, activity value is MIC = 4.69 ug/ml||Anti-C. albicans 1 Clinically isolated strain, activity value is MIC = 4.69 ug/ml||Anti-A. hydrophila, activity value is MIC = 2.34 ug/ml||Anti-V. parahaemdyticus, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae 2, activity value is MIC = 4.69 ug/ml||Anti-K. pneumoniae 3, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae 4, activity value is MIC = 9.38 ug/ml||Anti-K. pneumoniae 5, activity value is MIC = 18.75 ug/ml||Anti-K. pneumoniae 6, activity value is MIC = 37.5 ug/ml||Anti-K. pneumoniae 7, activity value is MIC = 37.5 ug/ml||Anti-K. pneumoniae 8, activity value is MIC = 75 ug/ml||Anti-Klebsiella oxytoca, activity value is MIC = 4.69 ug/ml||Anti-Proteus mirabilis, activity value is MIC = 4.69 ug/ml||Anti-S. maltophilia 2, activity value is MIC = 9.38 ug/ml||Anti-Pseudomonas aeruginosa ATCC27853, activity value is MIC = 18.75 ug/ml||Anti-P. aeruginosa 1, activity value is MIC = 37.5 ug/ml||Anti-Salmonella paratyphi A, activity value is MIC = 4.69 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 4.69 ug/ml||Anti-S. aureus 4, activity value is MIC = 4.69 ug/ml||Anti-S. aureus 5, activity value is MIC = 4.69 ug/ml||Anti-Bacillus cereus, activity value is MIC = 9.38 ug/ml||Anti-Bacillus subtilis, activity value is MIC = 75 ug/ml||Anti-Enterococcus faecium, activity value is MIC = 37.5 ug/ml||Anti-Nocardia asteroides, activity value is MIC = 9.38 ug/ml||Anti-Candida albicans 1, activity value is MIC = 4.69 ug/ml||Anti-C. albicans 2, activity value is MIC = 4.69 ug/ml||Anti-C. albicans 3, activity value is MIC = 4.69 ug/ml||Anti-C. albicans 4, activity value is MIC = 4.69 ug/ml||Anti-C. albicans 5, activity value is MIC = 2.34 ug/ml||Anti-C. albicans 6, activity value is MIC = 2.34 ug/ml||Anti-Candida glabrata 1, activity value is MIC = 2.34 ug/ml||Anti-Arcyria cinerea, activity value is MIC = 9.38 ug/ml||Anti-Aeromonas sobria, activity value is MIC = 2.34 ug/ml||Anti-Aeromonas hydrophila, activity value is MIC = 2.34 ug/ml||Anti-Aeromonas veronii, activity value is MIC = 2.34 ug/ml||Anti-Vibrio vulnificus, activity value is MIC = 4.69 ug/ml||Anti-Vibrio harveyi, activity value is MIC = 9.38 ug/ml||Anti-Vibrio fluvialis, activity value is MIC = 4.69 ug/ml||Anti-Vibrio alginolyticus, activity value is MIC = 4.69 ug/ml||Anti-Vibrio parahaemdyticus, activity value is MIC = 9.38 ug/ml||Anti-Vibrio splendidus, activity value is MIC = 2.34 ug/ml||Anti-Vibrio anguillarum, activity value is MIC = 18.75 ug/ml||Anti-Edwardsiella tarda, activity value is MIC = 2.34 ug/ml||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Anti-inflammatory||anti-sepsis||Antibiofilm||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2.34 ug/ml||activity value is MIC = 4.69 ug/ml||Anti-Escherichia coli 1, activity value is MIC = 2.34 ug/ml||Anti-Escherichia coli 2, activity value is MIC = 2.34 ug/ml||Anti-Escherichia coli 3, activity value is MIC = 2.34 ug/ml||Anti-Escherichia coli 4, activity value is MIC = 9.38 ug/ml||Anti-Shigella dysenteriae, activity value is MIC = 0.59 ug/ml||Anti-Klebsiella pneumoniae 1, activity value is MIC = 37.5 ug/ml||Anti-Klebsiella pneumoniae 2, activity value is MIC = 4.69 ug/ml||Anti-Klebsiella pneumoniae 3, activity value is MIC = 9.38 ug/ml||Anti-Klebsiella pneumoniae 4, activity value is MIC = 9.38 ug/ml||Anti-Klebsiella pneumoniae 5, activity value is MIC = 18.75 ug/ml||Anti-Klebsiella pneumoniae 6, activity value is MIC = 37.5 ug/ml||Anti-Klebsiella pneumoniae 7, activity value is MIC = 37.5 ug/ml||Anti-Klebsiella pneumoniae 8, activity value is MIC = 75 ug/ml||Anti-Serratia marcescens, activity value is MIC > 200 ug/ml||Anti-Proteus vulgaris, activity value is MIC > 200 ug/ml||Anti-Acinetobacter baumannii 1, activity value is MIC > 200 ug/ml||Anti-Acinetobacter baumannii 2, activity value is MIC > 200 ug/ml||Anti-Stenotrophomonas maltophilia, activity value is MIC > 200 ug/ml||Anti-Stenotrophomonas maltophilia 2, activity value is MIC = 9.38 ug/ml||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 18.75 ug/ml||Anti-Pseudomonas aeruginosa 1, activity value is MIC = 37.5 ug/ml||Anti-Pseudomonas aeruginosa, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4.69 ug/ml||Anti-Staphylococcus aureus 1, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus 2, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus 3, activity value is MIC > 200 ug/ml||Anti-Staphylococcus aureus 4, activity value is MIC = 4.69 ug/ml||Anti-Staphylococcus aureus 5, activity value is MIC = 4.69 ug/ml||Anti-Enterococcus faecalis, activity value is MIC > 200 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC > 200 ug/ml||Anti-Candida albicans 2, activity value is MIC = 4.69 ug/ml||Anti-Candida albicans 3, activity value is MIC = 4.69 ug/ml||Anti-Candida albicans 4, activity value is MIC = 4.69 ug/ml||Anti-Candida albicans 5, activity value is MIC = 2.34 ug/ml||Anti-Candida albicans 6, activity value is MIC = 2.34 ug/ml||Anti-Candida glabrata, activity value is MIC > 200 ug/ml||Anti-Cryptococcus neoformans, activity value is MIC > 200 ug/ml||Anti-Pathogenic bacteria:Aeromonas sobria, activity value is MIC = 2.34 ug/ml||Anti-Vibrio parahaemolyticus, activity value is MIC = 9.38 ug/ml||Anti-##Gram-positive bacteria:Staphylococcus aureus ATCC 25923, activity value is MIC = 4.69 ug/ml||Anti-##Fungi:Candida albicans 1, activity value is MIC = 4.69 ug/ml||Anti-##Pathogenic bacteria:Aeromonas sobria, activity value is MIC = 2.34 ug/ml	venom gland, spleen, and lung, annulated sea snake, Hydrophis cyanocinctus, Asia|||Hydrophis cyanocinctus [Asian annulated sea snake ]|||venom gland, spleen, and lung, annulated sea snake, Hydrophis cyanocinctus, Asia|||Hydrophis cyanocinctus|||Hydrophis cyanocinctus [Asian annulated sea snake ]|||venom gland, spleen, and lung, annulated sea snake, Hydrophis cyanocinctus, Asia|||Hydrophis cyanocinctus	Helix||Alpha helix,β-sheet,random coil	"venom gland, spleen, and lung, annulated sea snake, Hydrophis cyanocinctus|||Human erythrocytes ( 5.25% at 200 ug/ml )|||The document explicitly provides the hemolytic values of sea snake cathelicidin (Hc-CATH), with specific information as follows:

At a concentration of 200 μg/ml (approximately 55.12 μM, which is nearly 10 times the MIC value against most tested microorganisms), Hc-CATH has a hemolysis rate of 5.25% on human red blood cells.

This data was determined through a hemolysis assay: 1% Triton X-100 (v/v) was used as the 100% hemolysis positive control, 0.9% physiological saline as the negative control, and the hemolysis rate of Hc-CATH at different concentrations was recorded. At a concentration of 200 μg/ml, the hemolysis rate was 5.25%, demonstrating its low hemolytic activity on mammalian red blood cells.|||The hemolytic value of Hc-CATH is: at a concentration of 200 µg/ml (55.12 µM), the hemolysis rate of human red blood cells is 5.25%.|||Human erythrocytes ( 5.25% at 200 ug/ml )|||HC-Cath has very low cytotoxicity to the tested mammalian cells. At a concentration of 200 μg/ml (55.12 μM, nearly 10 times higher than the MIC for most tested microorganisms), the cell death rates induced by HC-Cath were 4.70%, 3.63%, 1.30%, and 4.28%, respectively. In terms of hemolytic activity, the hemolysis rate of HC-Cath was 5.25% at the same concentration of 200 μg/ml. The adsorption and attachment of HC-CathBin to bacteria are the first steps of AMP-mediated cell killing.|||[Ref.26013823]5.25% Hemolysis against Human erythrocytes at 200 ug/ml(55.12 uM).|||Cytotoxicity and Hemolysis of Hc-CATH—As shown in Table6,Hc-CATH exhibited very low cytotoxicity toward the tested mammalian cells.At concentrations up to200 ug/ml(55.12u M,nearly 10-fold high than the MICs of most tested microorganisms), Hc-CATH induced cell death per-centages as low as 4.70, 3.63, 1.30, and 4.28% for HepG2, PC3,L929,and mouse peritoneal macrophage cells,respectively. As to hemolytic activity,Hc-CATH yielded a hemo lysis of 5.25%,at the same concentration of 200 ug/ml."	"2015 Jul 3;290(27):16633-52. doi: 10.1074/jbc.M115.642645. Epub 2015 May 26||Ouyang et al., 2022||Wang et al., 2022|||J Biol Chem. 2015 Jul 3;290(27):16633-52. PubMed||Ouyang et al., 2022||Wang et al., 2022||He et al., 2022|||26013823|||J Biol Chem. 2015 Jul 3;290(27):16633-52. PubMed|||J Biol Chem. 2015 Jul 3;290(27):16633-52.||Ref.26013823|||26013823|||J Biol Chem
. 2015 Jul 3;290(27):16633-52. doi: 10.1074/jbc.M115.642645. Epub 2015 May 26.||Ouyang et al., 2022||Wang et al., 2022||He et al., 2022|||J Biol Chem. 2015 Jul 3;290(27):16633-52.||Ref.26013823|||J Biol Chem. 2015 Jul 3;290(27):16633-52. PubMed"	30	
FPDB01504	AP02570|||AP02570|||GL13K|||L-GL13K|||DRAMP21405	GKIIKLKASLKLL	Anti-P. aeruginosa, activity value is MIC = 8 ug/ml||Anti-E. coli, activity value is MIC = 5 ug/ml||Anti-S. gordonii, activity value is MIC = 64 ug/ml||Antibacterial||Anti-S. gordonii M5, activity value is MIC = 128 ug/ml||Anti-Pseudomonas aeruginosa Xen41, activity value is MIC = 32 ug/ml||Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis||Antibiofilm||Anti-Staphylococcus aureus Xen36, activity value is MIC = 83.3 ug/ml||Anti-##Gram-negative bacteria: Pseudomonas aeruginosa, activity value is MIC = 10.4 ug/ml	a synthetic peptide derived from human Parotid secretory protein, designed|||Homo sapiens [Human]|||Synthetic construct|||synthetic construct	Beta	a synthetic peptide derived from human Parotid secretory protein, designed|||[Ref.31071184] LD50=560 ug/ml against human blood cells	2012 Jan;359(1-2):1-8. doi: 10.1007/s11010-011-0991-2. Epub 2011 Jul 16.|||Mol Cell Biochem. 2012 Jan;359(1-2):1-8. PubMed||Harmouche N et al., 2017|||30753942|||30534763|||Mol Cell Biochem. 2012 Jan;359(1-2):1-8. PubMed|||PLoS One. 2019 May 9;14(5):e0216669. doi: 10.1371/journal.pone.0216669. eCollection 2019.||Ref.31071184	13	
FPDB01505	AP02621|||AP02621|||Cecropin Sb, SibaCec	GKLTKDKLKRGAKKALNVASKVAPIVAAGASIAR	Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis||Antibacterial	salivary glands, the black fly salivary glands, Simulium bannaense|||Simulium bannaense	Helix	: At concentrations as high as 200 µg/ml (approximately 58.27 µM), the hemolysis rate of human red blood cells is only 3.25%.|||salivary glands, the black fly salivary glands, Simulium bannaense||The hemolytic activity of antimicrobial peptides against mammalian erythrocytes is often used as to measure their cytotoxicity. The hemolytic experiment performed to evaluate the toxicity of the peptides H1 and H2 did not show measurable toxic effect against RBC (~ 1%)at MIC concentrations (Figure 4). A slight hemolytic activity, about 12.5%, was evident only at the highest concentration (50000 ug/ml) (Figure 4).|||Human erythrocytes (3% Hemolysis at 200 ug/ml	2015 Oct 24:8:561. doi: 10.1186/s13071-015-1176-8.|||Parasit Vectors. 2015 Oct 24;8(1):561. PubMed|||26497304	34	
FPDB01506	AP02629|||AP02629|||Cathelicidin Cl, dCATH|||DRAMP29074	KRFWQLVPLAIKIYRAWKRR	Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis||Hemolytic||Anti-Escherichia coli ATCC 25922, activity value is MIC = 2 uM||Anti-Escherichia coli UB1005, activity value is MIC = 2 uM||Anti-Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028, activity value is MIC = 4 uM||Anti-Salmonella enterica subsp. enterica serovar Pullorum C79-13, activity value is MIC = 8 uM||Anti-Staphylococcus aureus ATCC 29213, activity value is MIC = 4 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 4 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 4 uM||Anti-Bacillus subtilis CMCC 63501, activity value is MIC = 8 uM||Anti-S. aureus KCTC 1621, activity value is MIC = 8 uM||Anti-S. epidermidis KCTC 1917, activity value is MIC = 8 uM||Anti-B. subtilis KCTC 3068, activity value is MIC = 8 uM||Anti-##Resistant Gram-positive bacteria: MRSA CCARM 3089, activity value is MIC = 16 uM||Anti-MRSA CCARM 3090, activity value is MIC = 16 uM||Anti-MRSA CCARM 3095, activity value is MIC = 8 uM||Anti-V ATCC 51559, activity value is MIC = 16 uM||Anti-##Gram-negative bacteria: E. coli KCTC 1682, activity value is MIC = 8 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 16 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 4 uM||Anti-##Resistant Gram-negative bacteria: MDRPAd CCARM 2095, activity value is MIC = 16 uM||Anti-MDRPA CCARM 2109, activity value is MIC = 16 uM||Anti-##Yeast: C. albicans KCTC 7965, activity value is MIC = 8 uM||Anti-C. albicans KCTC 7121, activity value is MIC = 16 uM	Shaoxing ducks, Anas platyrhynchos|||Columba livia|||Anas platyrhynchos platyrhynchos (Northern mallard)	Helix	Shaoxing ducks, Anas platyrhynchos||The pOf-Pis1 demonstrated very weak hemolytic activity(Fig. 10). Even at the highest concentration (56020 uM), pOf-Pis1lysed less than 3.25% of erythrocytes, compared to the positivecontrol in 0.5 h. The lowest concentration (110 uM) lysed ~1.7% oferythrocytes.|||Human erythrocytes (50% Hemolysis at 20 uM|||[Ref.32698035] HC10 = 5.1 uM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	2015 Nov 26:5:17260. doi: 10.1038/srep17260.|||Sci Rep. 2015 Nov 26;5:17260. PubMed|||26608073|||Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.||Ref.32698035	20	
FPDB01507	AP02637|||AP02637|||MBjAMP1	NLCASLRARHTIPQCKKFGRR	Anti-Gram+ & Gram-||anti-sepsis||Antibacterial	Japanese lancelet, Branchiostoma japonicum|||Synthetic construct	Helix	Without 10% fetal bovine serum (FBS), the concentration causing 50% hemolysis of human red blood cells (HC50) is 20 μM; with 10% FBS, the HC50 is 32 μM|||Japanese lancelet, Branchiostoma japonicum	2015 Dec 18:5:18355. doi: 10.1038/srep18355.|||Sci Rep. 2015 Dec 18;5:18355. doi: 10.1038/srep18355. PubMed|||34733268	21	
FPDB01508	AP02662|||DRAMP20772	PPHKKKLAVYPVFLFYLFLSWFSLIV	: Active against A. hydrophila ATCC 35654 (killed 77% at 25 ug/ml)||and Gram+ S. aureus ATCC 25923 (killed 42% at 25 ug/ml). It binds to LPS and LTA.||Active against A. hydrophila ATCC 35654 (killed 77% at 25 ug/ml)||cPcAMP1/26 is capable of markedly killing A. hydrophila and S. aureus (p < 0.05)||with the bactericidal rates being 27.7%||31.7% and 40.1% as well as 34.4%||47.4% and 49.2%||respectively	Paramecium caudatum	Helix	Paramecium caudatum|||[Ref.26883426] cPcAMP1/26 showed little hemolytic activity towards human erythrocytes at 100 ug/ml	2016 Jul:60:53-65. doi: 10.1016/j.dci.2016.02.016. Epub 2016 Feb 13|||Dev Comp Immunol. 2016 Jul;60:53-65. PubMed|||Dev Comp Immunol. 2016 Jul;60:53-65.||Ref.26883426	26	
FPDB01509	AP02716|||AP02716|||Kunitzin-RE|||Kunitzin-RE|||DRAMP18450	AAKIILNPKFRCKAAFC	Anti-E. coli, activity value is MIC = 30 uM||Anti-E. coli 25922, activity value is MIC = 32 uM||Anti-E. coli 1005, activity value is MIC = 64 uM||Anti-S. typhimurium 14028, activity value is MIC = 64 uM||Anti-S. pullorum 7913, activity value is MIC = 64 uM||Anti-E. coli K88, activity value is MIC = 32 uM||Anti-E. coli K99, activity value is MIC = 32 uM	European frog, Rana esculenta|||Synthetic construct|||Rana esculenta	N/A	European frog, Rana esculenta||In summary, the putative peptide To-KL37 had the largest hydrophobic face, greater hydrophobicity, and a higher score in predicted antimicrobial activity among the four small mammals studied. Therefore, To-KL37 was selected to further investigate the antimicrobial and hemolytic activity in vitro against various microorganisms and human erythrocytes, respectively. In our in vitro analysis of antimicrobial activity, To-KL37 exerted broad spectrum activity but moderate antimicrobial abilities, with MIC values ranging from 0.78 to 25 uM depending on the bacteria tested (Table 6).|||Human RBCs [10% hemolysis at 32 uM]|||Human RBCs [10% hemolysis at 32 uM]|||No hemolysis information or data found in the reference(s) presented in this entry	2016 Aug 19;477(2):302-9. doi: 10.1016/j.bbrc.2016.06.062. Epub 2016 Jun 14.|||Biochem Biophys Res Commun. 2016 Aug 19;477(2):302-9. PubMed|||30958004|||27311856|||30958004|||Biochem Biophys Res Commun. 2016 Aug 19;477(2):302-9.	17	
FPDB01510	AP02752|||AP02753	QSWHGGRPGGFPGGGRPGGFPGGGRPGGRPGGFPSVTAPPASCRRWCETPENAFYCCESRYEPEAPVGTKILDCPKVRDTCPPVRFLAVEQP	Anti-Gram+ & Gram-||anti-sepsis	hemocytes; black tiger shrimp, Penaeus monodon	Helix	N/A	2012 Jan;36(1):208-15. doi: 10.1016/j.dci.2011.08.002. Epub 2011 Aug 9.	92	
FPDB01511	AP02872|||AP02872|||Esculentin-1a|||DRAMP32294	GIFSKLAGKKIKNLLISGLKG	Anti-fungus S. cerevisiae. Subsequent studies: active against S. agalactiae and P. aeruginosa/biofilms. Also active against C. jeikeium ATCC BAA-949, activity value is MIC = 0.125 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 4 uM||Anti-P. aeruginosa AA11, activity value is MIC = 2 uM||Anti-P. aeruginosa AA43, activity value is MIC = 2 uM||Anti-P. aeruginosa KK1, activity value is MIC = 4 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1 uM||Anti-P. aeruginosa AA11, activity value is MIC = 1 uM||Anti-P. aeruginosa KK1, activity value is MIC = 1 uM||Anti-P. aeruginosa TR1, activity value is MIC = 1 uM||Anti-P. aeruginosa PAO1, activity value is MIC = 4 uM||Anti-P. aeruginosa MDR 1 clinical isolate, activity value is MIC = 4 uM||Anti-P. aeruginosa MDR 2 clinical isolate, activity value is MIC = 8 uM||Anti-P. aeruginosa MDR 3 clinical isolate, activity value is MIC = 4 uM||Anti-P. aeruginosa AA11, activity value is MIC = 4 uM||Anti-P. aeruginosa TR1, activity value is MIC = 4 uM||Anti-P. aeruginosa AA43, activity value is MIC = 4 uM||Anti-P. aeruginosa TR67, activity value is MIC = 4 uM||Anti-Gram+ & Gram-||Antifungal||Chemotactic||anti-sepsis||Synergistic AMPs||Antibiofilm||Wound healing||Antimicrobial||Anticancer	Sequence truncation|||Pelophylax lessonae [Edible frog]|||Synthetic	Helix	Sequence truncation|||Sheep erythrocytes: 10% Hemolysis=64 uM	"2007 Jun;1774(6):688-700. doi: 10.1016/j.bbapap.2007.04.006. Epub 2007 Apr 21.|||Biochim Biophys Acta
. 2007 Jun;1774(6):688-700. doi: 10.1016/j.bbapap.2007.04.006. Epub 2007 Apr 21.|||31144441, 26162435, 23503622||Refer PubMed ID: 31144441||Refer PubMed ID: 26162435||Refer PubMed ID: 23503622|||Biochim Biophys Acta. 2007 Jun;1774(6):688-700. PubMed|||Biochim Biophys Acta
. 2007 Jun;1774(6):688-700. doi: 10.1016/j.bbapap.2007.04.006. Epub 2007 Apr 21.|||Antibiotics (Basel). 2020 Jul 26;9(8):448."	21	
FPDB01512	AP02897|||AP02897|||AdCath	RPKKVQGRKAEKDNGDGTTAANASGKKKSSNVFK	Anti-M. luteus, activity value is MIC = 2.7||Antibacterial	skin, Chinese giant salamanders, Andrias davidianus, China, Asia|||Andrias davidianus [Chinese giant salamander]	N/A	skin, Chinese giant salamanders, Andrias davidianus, China, Asia	"2017 Dec:77:141-149. doi: 10.1016/j.dci.2017.08.002. Epub 2017 Aug 9.|||Dev Comp Immunol
. 2017 Dec:77:141-149. doi: 10.1016/j.dci.2017.08.002. Epub 2017 Aug 9.|||28801228"	34	
FPDB01513	AP02898|||AP02899|||AP02900|||AP02898|||As-CATH4|||AP02898|||DRAMP32057	RRGLFKKLRRKIKKGFKKIFKRLPPVGVGVSIPLAGRR	Active against Gram- bacteria E. coli||S. dysenteriae||K. pneumoniae||K. oxytoca||P. vulgaris||P. mirabilis||A. baumannii||S. maltophilia||and P. aeruginosa||Gram+ bacteria S. aureus||B. cereus||E. faecium||and S. epidermidis||and fungi C. albicans. Also active against aquatic pathogenic bacteria A. sobria||A. hydrophila||A. veronii||V. harveyi||V. parahaemdyticus||V. anguillarum||and V. cholerae. Antibacterial activity appears to be salt-resistant (salt-insensitive). At a high concentration of 200 ug/ml||it showed only 4% hemolysis (human red blood cells).||Antibacterial||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis	Chinese alligator, Alligator sinensis|||Alligator sinensis|||Chinese alligator, Alligator sinensis	Helix	Chinese alligator, Alligator sinensis||As shown in Table 5, As-CATH4~6 exhibited selective cytotoxicity toward the tested mammalian cells. Among the three tested cells, CHO cell were the most sensitive to As-CATH4~6. At a concentration of 200 ug/ml, As-CATH4~6 induced CHO death rates of 55%, 89% and 89%, respectively. Among the three peptides, As-CATH4 was the least cytotoxic. At a concentration of 200 ug/ml, As-CATH4 induced death rates of 27%, 55% and 17% for BGC-823, CHO and mouse peritoneal macrophages, respectively. As to hemolytic activity, As-CATH4~6 yielded hemolytic rates of 4%, 47%, and 48% respectively toward human erythrocytes. However, it should be noted that the concentrations of As-CATH4~6 in cytotoxic and hemolytic assays were nearly 10-fold higher than their MICs toward most of the tested microorganisms. At a concentration of 20 ug/ml, the cytotoxic and hemolytic rates induced by As-CATH4~6 significantly decreased to below 10%, suggesting their potential in therapeutic application (data not shown). Unlike As-CATH4~6, As-CATH1~3 didn’t show apparent cytotoxic and hemolytic activities (data not shown).|||Human erythrocytes: 4±0.5% Hemolysis=200 ug/ml|||As to hemolytic activity, As-CATH4~6 yielded hemolytic rates of 4%, 47%, and 48% respectively toward human erythrocytes. However, it should be noted that the concentrations of As-CATH4~6 in cytotoxic and hemolytic assays were nearly 10-fold higher than their MICs toward most of the tested microorganisms. At a concentration of 20 ug/ml, the cytotoxic and hemolytic rates induced by As-CATH4~6 significantly decreased to below 10%, suggesting their potential in therapeutic application (data not shown). Unlike As-CATH4~6, As-CATH1~3 didn’t show apparent cytotoxic and hemolytic activities (data not shown).	"2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334.|||Biochem J
. 2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334.|||29017942|||Biochem J
. 2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334.|||Biochem J. 2017 Aug 10;474(16):2861-2885.|||Biochem J. 2017 Aug 10;474(16):2861-2885. doi: 10.1042/BCJ20170334. PubMed"	38	
FPDB01514	AP02901|||AP02901|||Cathelicidin-PP|||Cathelicidin-PP|||AP02901	ASENGKCNLLCLVKKKLRAVGNVIKTVVGKIA	Anti-Gram- bacteria E. coli ATCC 25922, activity value is MIC = 0.69 uM||Anti-S. paratyphi A ATCC 9150, activity value is MIC = 1.39 uM||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 1.39 uM||Anti-A. junii ATCC 17908, activity value is MIC = 2.78 uM||Anti-S. epidermidis ATCC 12228, activity value is MIC = 5.57 uM||Anti-S. haemolyticus ATCC 29970, activity value is MIC = 5.57 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 5.57 uM||Anti-C. glabrata ATCC 66032, activity value is MIC = 1.39 uM||Anti-and C. albicans ATCC 14053, activity value is MIC = 5.57 uM||Antibacterial||Antifungal||Anti-Escherichia coli ATCC 25922, activity value is MIC = 0.69 uM||Anti-Salmonella paratyphi A ATCC 9150, activity value is MIC = 1.39 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 1.39 uM||Anti-Acinetobacter junii ATCC 17908, activity value is MIC = 2.78 uM||Anti-Staphylococcus epidermidis ATCC 12228, activity value is MIC = 5.57 uM||Anti-Staphylococcus haemolyticus ATCC 29970, activity value is MIC = 5.57 uM||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC = 5.57 uM||Anti-Candida glabrata ATCC 66032, activity value is MIC = 1.39 uM||Anti-Candida albicans ATCC 14053, activity value is MIC = 5.57 uM	skin; frog, Polypedates puerensis, China, Asia|||Polypedates puerensis|||Polypedates puerensis|||skin; frog, Polypedates puerensis, China, Asia	Helix	skin; frog, Polypedates puerensis, China, Asia||Cathelicidin-PP exhibited very low cytotoxicity toward mouse peritoneal macrophages. Cathelicidin-PP induced cell death percentages as low as 7.06% at concentrations up to 200 ug/ml (59.42 uM), which is almost 86-fold higher than the MIC value of cathelicidin-PP against E. coli ATCC 25922. Additionally, cathelicidin-PP also showed low hemolytic activity against erythrocytes, and it yielded a hemolysis of 5.65% at the same concentration of 200 ug/ml.|||Rabbit erythrocytes (5.65% hemolysis at 200 ug/ml)|||Rabbit erythrocytes (5.65% hemolysis at 200 ug/ml)	"2017 Sep;49(9):1571-1585. doi: 10.1007/s00726-017-2449-7.|||Amino Acids
. 2017 Sep;49(9):1571-1585. doi: 10.1007/s00726-017-2449-7. Epub 2017 Jun 7.|||28593346|||28593346|||Amino Acids
. 2017 Sep;49(9):1571-1585. doi: 10.1007/s00726-017-2449-7. Epub 2017 Jun 7."	32	
FPDB01515	AP02928	KTKKKFLKKT	Polymyxin B is anti-film of P. mirabilis  . BInds LPS:anti-inflammatory by supressing TNF-alpha released from murine RAW 264.7 cells and in vivo animal model:mouse:sepsis  . It also has antifungal activity in vivo (Zhai and Lin 2013).||Polymyxin B is anti-film of P. mirabilis  . It also has antifungal activity in vivo (Zhai and Lin 2013).||Anti-Gram-||Antifungal||Anti-inflammatory||anti-sepsis||Antibiofilm	Bacillus aerosporus Greer	N/A	Bacillus aerosporus Greer	"1947 Aug 23;159(4060):263. doi: 10.1038/160263a0.||see ref for AP3643||Liu MC et al., 2012|||Nature
. 1947 Aug 23;159(4060):263.doi: 10.1038/160263a0.||Liu MC et al., 2012|||Nature. 1947 Aug 23;159(4060):263. PubMed, no abstract|||Nature
. 1947 Aug 23;159(4060):263. doi: 10.1038/160263a0.||see ref for AP3643||Liu MC et al., 2012"	10	
FPDB01516	AP03002	NWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPADRRANYPVFCVQTKTTRISTVTATTATTTLMMTTASMSSMAPTPVSPTG	The core defensin region (sequence: NWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPAD) was recombinantly expressed in 2013 and found to have antimicrobial activity against E. coli K12D31||S. aureus CMCC 26003||and C. albicans SC 5314  . This form also has moderate LPS binding ability||thereby anti-inflammatory in nature||thereby anti-inflammatory in nature.	epididymis, Homo sapiens	Bridge	epididymis, Homo sapiens	"2013 Apr;97(8):3395-408. doi: 10.1007/s00253-012-4588-9. Epub 2012 Dec 11.||see the ref|||Appl Microbiol Biotechnol
. 2013 Apr;97(8):3395-408. doi: 10.1007/s00253-012-4588-9. Epub 2012 Dec 11.||see the ref|||Appl Microbiol Biotechnol
. 2013 Apr;97(8):3395-408. doi: 10.1007/s00253-012-4588-9.||see the ref"	91	
FPDB01517	AP03012	RKCNFLCKVKNKLKSVGSKSLIGSATHHGIYRV	Anti-Active against E. coli ATCC25922, activity value is MIC = 10.2 uM||Anti-P. aeruginosa ATCC27853, activity value is MIC = 10.2 uM||Anti-H. pylori 26695 or 11637, activity value is MIC = 2.55 uM||Anti-and Gram+ S. aureus ATCC25923, activity value is MIC = 20.42 uM||Anti-and S.epidermidis clinical strains, activity value is MIC > 200 ug/ml||Anti-E. coli ATCC25922, activity value is MIC = 10.2 uM	frog, Odorrana livida, China, Asia|||N/A (Green Stink Frog)	N/A	frog, Odorrana livida, China, Asia	"2019 Mar 18;40(2):94-101. doi: 10.24272/j.issn.2095-8137.2018.062. Epub 2018 Jul 31|||Zool Res
. 2019 Mar 18;40(2):94-101. doi: 10.24272/j.issn.2095-8137.2018.062. Epub 2018 Jul 31."	33	
FPDB01518	AP03031|||AP03031|||Esculentin-1GN	GLFSKKGGKGGKSWIKGVFKGIKGIGKEVGGDVIRTGIEIAACKIKGEC	Anti-E. coli ATCC 25922, activity value is MIC = 3.7 uM||Anti-P. aeruginosa, activity value is MIC = 50 uM||Anti-S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant, activity value is MIC = 1.9||Anti-P. acnes, activity value is MIC = 1.17 uM||Anti-S. subtilis ATCC 6633, activity value is MIC = 3.1 uM||Anti-and C. albicans, activity value is MIC = 4.7 uM||Antibacterial||Antifungal ; S.aureus||E. coli||P. aeruginosa||C. albicans||Anti-Gram+ & Gram-||Antiviral||Antifungal||candidacidal||Antioxidant||Anti-inflammatory||anti-sepsis	kin, Hylarana guentheri, Asia|||Hylarana guentheri [Günther's frog]|||skin, Hylarana guentheri, Asia|||skin, Hylarana guentheri, Asia	Helix	"Esculentin-1GN: At a concentration of 40 μM, the hemolysis rate on human red blood cells is only 6.2%.|||skin, Hylarana guentheri, Asia|||The hemolytic ability of hederagenin-1GN was determined using human red blood cells. As shown in Table S5, hederagenin-1GN has a low hemolytic activity on human red blood cells. At a concentration of 40 μM, the hemolysis rate of human red blood cells was only 6.2%.|||In the provided document, the hemolysis-related data for the novel antimicrobial peptide Esculentin-1GN are as follows:

- Hemolysis rate: At a concentration of 40 μM, Esculentin-1GN exhibited a hemolysis rate of only 6.2% on human red blood cells, indicating low hemolytic activity.

This data was measured through a human red blood cell hemolysis assay, in which hemolysis induced by 0.1% Triton X-100 was used as the 100% control to assess the degree of red blood cell damage (hemoglobin release) at different peptide concentrations.|||As shown in Table S5, Esculentin-1GN showed a low hemolytic activity on human red cells. At concentrations of 40 uM, the hemolysis ratio of human red cells was only 6.2%."	"2018 Dec 13;61(23):10709-10723. doi: 10.1021/acs.jmedchem.8b01358. Epub 2018 Nov 27.|||J Med Chem
. 2018 Dec 13;61(23):10709-10723. doi: 10.1021/acs.jmedchem.8b01358. Epub 2018 Nov 27.|||30427189|||J Med Chem
. 2018 Dec 13;61(23):10709-10723. doi: 10.1021/acs.jmedchem.8b01358. Epub 2018 Nov 27.|||J Med Chem. 2018 Nov 14. 61 (23), 10709-10723. doi: 10.1021/acs.jmedchem.8b01358. PubMed|||J Med Chem. 2018 Nov 14. 61 (23), 10709-10723. doi: 10.1021/acs.jmedchem.8b01358. PubMed"	49	
FPDB01519	AP03044|||AP03044|||YR26	YYHFWHRGVTKRSLSPHRPRHSRLQR	Anti-E. coli, activity value is MIC = 2 uM||Anti-P. aeruginosa, activity value is MIC = 4 uM||Anti-S. enterica, activity value is MIC = 4 uM||Anti-K. pneumoniae, activity value is MIC = 2 uM||Anti-S. aureus, activity value is MIC = 4 uM||Anti-B. subtilis, activity value is MIC = 2 uM||Anti-S. pyogenes, activity value is MIC = 4 uM||Anti-and E. faecalis, activity value is MIC = 4 uM||Anti-Escherichia coli, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 4 uM||Anti-S. enterica ATCC 14028, activity value is MIC = 4 uM||Anti-Klebsiella pneumoniae ATCC 13883, activity value is MIC = 2 uM||Anti-Staphylococcus aureus ATCC 25923, activity value is MIC = 4 uM||Anti-S. pyogenes ATCC 19615, activity value is MIC = 4 uM||Anti-E. faecalis ATCC 29212, activity value is MIC = 4 uM||Anti-Staphylococcus aureus ATCC BAA-44, activity value is MIC = 6 uM||Anti-S. epidermis ATCC 51625, activity value is MIC = 6 uM	Sequence truncation|||Homo sapiens [Human]	Helix	"YR26: At a concentration of 160 µM, the hemolysis rate in human red blood cells was only 7.65%;
YR23 and YR20 exhibited lower hemolysis rates than YR26, and YR23 showed the lowest cytotoxicity toward mouse fibroblasts (NIH3T3), with cell viability remaining essentially unaffected at a concentration of 100 µM.
RV23 (inactive peptide): At a concentration of 160 µM, the hemolysis rate reaches as high as 71%.|||Sequence truncation||0.0765|||hRBC (7.65% hemolysis at 160 uM)"	"2018 Nov 30;3(11):14650-14664. doi: 10.1021/acsomega.8b01876. Epub 2018 Nov 1.|||ACS Omega
. 2018 Nov 30;3(11):14650-14664. doi: 10.1021/acsomega.8b01876. Epub 2018 Nov 1.|||30555984"	26	
FPDB01520	AP03107	DDTRGGFHGGGFGRPGRPGRPGSGILDTIVDGLTGSIHGGQGGIHGGIHGGGHGGHGGVVHGRQCGVNVPTHITTGCKLFTRNLYGQYVCDRNQ	Anti-Gram+ S. aureus, activity value is MIC = 0.7||Anti-B. subtilis, activity value is MIC = 0.7||Anti-B. megaterium, activity value is MIC = 0.35||Anti-V. alginolyticus, activity value is MIC = 1.4||Anti-V. parahaemolyticus, activity value is MIC = 0.7||Anti-V. harveyi (MIC, activity value is MIC = 0.7||Anti-E. coli, activity value is MIC = 2.8||Anti-and fungi C. albicans, activity value is MIC = 2.8	the mud crab, Scylla paramamosain	N/A	N/A	2018 Jul:84:1-13. doi: 10.1016/j.dci.2018.01.021. Epub 2018 Feb 2	94	
FPDB01521	AP03139|||AP03139|||CAMPSQ10792|||Allomyrinasin|||AP03139	AAVTRRILCWFA	Anti-Gram+ & Gram-||Antifungal||candidacidal||Anti-inflammatory||anti-sepsis||Antibacterial	the Dynastid Beetle, Aloidendron dichotomum|||Allomyrina dichotoma|||Allomyrina dichotoma|||the Dynastid Beetle, Aloidendron dichotomum|||the Dynastid Beetle, Aloidendron dichotomum	N/A	the Dynastid Beetle, Aloidendron dichotomum	"2019 May 28;29(5):687-695. doi: 10.4014/jmb.1809.09031.|||J Microbiol Biotechnol
. 2019 May 28;29(5):687-695. doi: 10.4014/jmb.1809.09031.|||30955257|||30955257|||J Microbiol Biotechnol
. 2019 May 28;29(5):687-695. doi: 10.4014/jmb.1809.09031.|||J Microbiol Biotechnol 29 (5), 687-695 2019 May 28. PMID: 30955257 DOI: 10.4014/jmb.1809.09031. PubMed"	12	
FPDB01522	AP03151|||AP03151|||NLF20|||NLF20|||AP03151	NLFRKLTHRLFRRNFGYTLR	Anti-Gram- P. aeruginosa, activity value is MBC = 30 uM||Anti-E. coli, activity value is MBC < 10 uM||Antibacterial||Antifungal||Antifungal ; E. coli ATCC 25922||P. aeruginosa ATCC 27853||S. aureus ATCC 29213||B. subtilis ATCC 6633||C. albicans ATCC 90028||C. parapsilosis ATCC 90018||Anti-Gram+ & Gram-||candidacidal||Anti-inflammatory||anti-sepsis	fragments of a human antimicrobial protein, animal-derived, natural derivatives|||Synthetic construct	Helix	"At concentrations of 30-60 μM, only slight hemolysis occurs within the standard incubation time, with a hemolysis rate ≤2%; 
In human blood containing bacteria, the hemolysis rate at concentrations of 30-60 μM still remains ≤2%; 
After long-term incubation of 18 hours, the hemolysis rate at the highest antibacterial concentration (313 μg/ml) is only 5% (in a 50% blood system).|||fragments of a human antimicrobial protein, animal-derived, natural derivatives"	"2016 Jan;71(1):170-80. doi: 10.1093/jac/dkv322. Epub 2015 Oct 26.|||J Antimicrob Chemother
. 2016 Jan;71(1):170-80. doi: 10.1093/jac/dkv322. Epub 2015 Oct 26.|||26503666|||26503666|||J Antimicrob Chemother
. 2016 Jan;71(1):170-80. doi: 10.1093/jac/dkv322. Epub 2015 Oct 26.|||Biochim Biophys Acta. 2013;1828(11):2709–2719. doi:10.1016/j.bbamem.2013.06.015 PubMed"	20	
FPDB01523	AP03191	GFGCPLNQYQCNSHCKSIRCRAGYCDAATLWMRCTCTGCSGKVALFIT	Active against Gram bacterium A. hydrophila||Gram+ S. aureus.	digestive gland, the oyster, Magallana gigas	Bridge	digestive gland, the oyster, Magallana gigas	"2018 Aug:85:177-187. doi: 10.1016/j.dci.2018.04.014. Epub 2018 Apr 18|||Dev Comp Immunol
. 2018 Aug:85:177-187. doi: 10.1016/j.dci.2018.04.014. Epub 2018 Apr 18."	48	
FPDB01524	AP03192	GFGCPNDYSCSNHCRDSIGCRGGYCKYHVICTCYGCKKRRSIQE	Anti-GRam+ S. aureus ATCC 6538, activity value is MIC = 6||Anti-M. luteus ATCC 4698, activity value is MIC = 1.5||Anti-Gram+ & Gram-||Chemotactic||anti-sepsis||Antibiofilm	manila clam, Ruditapes philippinarum	Bridge	manila clam, Ruditapes philippinarum	"2020 Aug:103:266-276. doi: 10.1016/j.fsi.2020.05.025. Epub 2020 May 18.|||Fish Shellfish Immunol
. 2020 Aug:103:266-276. doi: 10.1016/j.fsi.2020.05.025. Epub 2020 May 18.|||Fish Shellfish Immunol. 2020; 103:266-276. doi:10.1016/j.fsi.2020.05.025. PubMed"	44	
FPDB01525	AP03227	GIKEFAHSLGKFGKAFFGGILNQ	Anti-including C. albicans NCTC 3179, activity value is MIC = 100 uM||Anti-S. mutans ATCC 10449, activity value is MIC = 50 uM||Anti-F. nucleatum NCTC 10562, activity value is MIC = 12.5 uM||Anti-Gram+ & Gram-||Antifungal||candidacidal||anti-sepsis	the octoploid frog, Xenopus amieti (Pipidae)|||the octoploid frog, Xenopus amieti (Pipidae)	N/A	the octoploid frog, Xenopus amieti (Pipidae)|||Magainin-AM1, magainin-AM2, and PGLa-AM2 dis played very low hemolytic activity (LC50 >200 uM) against human erythrocytes.	"2010 Jun;31(6):989-94. doi: 10.1016/j.peptides.2010.03.002. Epub 2010 Mar 10.||see the ref|||Peptides
. 2010 Jun;31(6):989-94. doi: 10.1016/j.peptides.2010.03.002. Epub 2010 Mar 10.||see the ref||McLean et al., 2014|||Peptides . 2010 Jun;31(6):989-94. doi: 10.1016/j.peptides.2010.03.002. PubMed"	23	
FPDB01526	AP03231|||AP03231|||Brevinin-2SSb|||DRAMP32299	SLFSLIKAGAKFLGKNMLKQGPQYPACKVSKDSENVNWKS	Anti-and P. aeruginosa and the fungus C. albicans, activity value is MIC = 30 uM||Antibacterial||Antifungal||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||candidacidal||Antioxidant||anti-sepsis	skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Glandirana susurra|||skin, the Sado Wrinkled Frog, Glandirana susurra, Asia	N/A	skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Monkey COS-7 cells (88.5% Killing at 32 ug/ml	"2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457|||Antibiotics (Basel)
. 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||32751229|||Antibiotics (Basel)
. 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||Antibiotics (Basel). 2020 Jul 29;9(8):457.|||Antibiotics (Basel). 2020 Jul 29;9(8):E457. doi: 10.3390/antibiotics9080457. PubMed"	40	
FPDB01527	AP03232|||AP03232|||Ranatuerin-2SSa|||Ranatuerin-2SSa|||AP03232|||DRAMP32298	GLISTIWNTASNVAGTLTDSVKCKFKKC	Active against the fungus C. albicans. Ranatuerin-2SSa was slightly active against plant pathogen C. michiganensis subsp. michiganensis. Moderate antioxidant activity (20 ug/ml at 21.9%).||Escherichia coli JCM 5491||Salmonella enterica JCM 1652[20-30% Inhibition = 128 ug/ml]||Pseudomonas aeruginosa JCM 6119[20-30% Inhibition = 128 ug/ml]||Staphylococcus aureus JCM 2874||Bacillus cereus JCM 2152||Candida albicans JCM 2085[70-80% Inhibition = 128 ug/ml]||Xanthomonas oryzae pv. oryzae MAFF 311018||Clavibacter michiganensis subsp. michiganensis MAFF 301254[60-70% Inhibition = 128 ug/ml]||Pyricularia oryzae MAFF 101511[10-20% Inhibition = 128 ug/ml]||Human hepatocellular carcinoma HepG2[80-90% Killing = 32 ug/ml]||Antibacterial||Antifungal ; Escherichia coli JCM 5491||Antimicrobial||Anticancer||Anti-Gram+||Antifungal||candidacidal||Antioxidant||anti-sepsis	skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Glandirana susurra|||Glandirana susurra|||skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||skin, the Sado Wrinkled Frog, Glandirana susurra, Asia	N/A	skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Monkey COS-7 cells (61.7% Killing at 32 ug/ml|||Monkey COS-7 cells (61.7% Killing at 32 ug/ml	"2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||Antibiotics (Basel)
. 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||32751229|||32751229|||Antibiotics (Basel)
. 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||Antibiotics (Basel). 2020 Jul 29;9(8):457.|||Antibiotics (Basel). 2020 Jul 29;9(8):E457. doi: 10.3390/antibiotics9080457. PubMed"	28	
FPDB01528	AP03233|||AP03233|||Granuliberin-SSa|||Granuliberin-SSa|||AP03233|||DRAMP32297	"	
FIFLPIFRRPVS"	Active against the fungus C. albicans. Granuliberin-SSa also showed activities that were almost equipotent to those of brevinin-2SSb against plant pathogens C. michiganensis subsp. michiganensis and P. oryzae. The peptide was also active against X. oryzae pv. oryzae at concentrations higher than 64 ug/ml. The peptide is toxic to mammalian cells (32 ug/ml||survival rates of COS7 and HepG2 (54.5% and 49.5%). Peptide sequence kindly provided by Prof. Iwamuro||survival rates of COS7 and HepG2 (54.5% and 49.5%). Peptide sequence kindly provided by Prof. Iwamuro.||Anti-Xanthomonas oryzae pv. oryzae MAFF 311018, activity value is MIC = 128 ug/ml||Anti-Clavibacter michiganensis subsp. michiganensis MAFF 301254, activity value is MIC = 16 ug/ml||Anti-Pyricularia oryzae MAFF 101511, activity value is MIC = 128 ug/ml||Antibacterial||Antifungal||Antimicrobial||Anticancer||Anti-Gram+ & Gram-||candidacidal||anti-sepsis	skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Glandirana susurra|||Glandirana susurra|||skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||skin, the Sado Wrinkled Frog, Glandirana susurra, Asia	N/A	skin, the Sado Wrinkled Frog, Glandirana susurra, Asia|||Monkey COS-7 cells (45.5% Killing at 32 ug/ml|||Monkey COS-7 cells (45.5% Killing at 32 ug/ml	"2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||Antibiotics (Basel)
. 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||32751229|||32751229|||Antibiotics (Basel)
. 2020 Jul 29;9(8):457. doi: 10.3390/antibiotics9080457.|||Antibiotics (Basel). 2020 Jul 29;9(8):457.|||Antibiotics (Basel). 2020 Jul 29;9(8):E457. doi: 10.3390/antibiotics9080457. PubMed"	12	
FPDB01529	AP03250|||Octominin	GWLIRGAIHAGKAIHGLIHRRRH	Anti-Weakly active against C. albicans, activity value is MIC = 50 ug/ml||Anti-which was essentially all killed at 100 ug/ml . Also showed significant activity against carbapenem-resistant E. coli, activity value is MIC = 4||Antifungal||candidacidal||anti-sepsis	screening transcriptome database of Octopus minor|||Octopus minor|||screening transcriptome database of Octopus minor	N/A	N/A	. 2020 Jan 15;18(1):56. doi: 10.3390/md18010056||see the 2023 Kong ref|||31952292|||Mar Drugs. 2020 Jan 15;18(1):56. doi: 10.3390/md18010056. PubMed	23	
FPDB01530	AP03272|||AP03272|||PN-CATH2|||PN-CATH2|||AP03272|||DRAMP35739	EGCNILCLLKRKVKAVKNVVKNVVKSVVG	Anti-S. castellani ATCC12022, activity value is MIC = 6 uM||Anti-E. coli ATCC 25922, activity value is MIC = 3 uM||Anti-V. parahaemolyticus, activity value is MIC = 3 uM||Anti-A. hydrophila, activity value is MIC = 11.9 uM||Anti-V. splendidus, activity value is MIC = 23.9 uM||Anti-active: S. aureus CMCC26003, activity value is MIC = 3 uM||Anti-B. subtilis CMCC63501, activity value is MIC = 11.9 uM||Anti-E.faecium, activity value is MIC > 100 uM||Anti-C.albicans and C.glabrata, activity value is MIC > 100 uM||Anti-Escherichia coli CMCC 44102, activity value is MIC = 18.75 ug/ml||Anti-Escherichia coli ATCC 25922, activity value is MIC = 9.38 ug/ml||Anti-Shigella flexneri ATCC 12022, activity value is MIC = 18.75 ug/ml||Anti-Pseudomonas aeruginosa CMCC 10104, activity value is MIC > 100 ug/ml||Anti-Vibrio parahaemolyticus, activity value is MIC = 9.38 ug/ml||Anti-Klebsiella pneumoniae, activity value is MIC > 100 ug/ml||Anti-Acinetobacter baumannii, activity value is MIC > 100 ug/ml||Anti-Vibrio harveyi, activity value is MIC = 75 ug/ml||Anti-Vibrio splendidus, activity value is MIC = 75 ug/ml||Anti-Aeromonas sobria, activity value is MIC > 100 ug/ml||Anti-Vibrio alginolyticus, activity value is MIC > 100 ug/ml||Anti-Vibrio vulnificus, activity value is MIC > 100 ug/ml||Anti-Aeromonas hydrophila, activity value is MIC = 37.5 ug/ml||Anti-Staphylococcus aureus CMCC 26003, activity value is MIC = 9.38 ug/ml||Anti-Bacillus subtilis CMCC 63501, activity value is MIC = 37.5 ug/ml||Anti-Clostridium perfringens ATCC 13124, activity value is MIC = 37.5 ug/ml||Anti-Bacillus cereus CMCC 63301, activity value is MIC > 100 ug/ml||Anti-Enterococcus faecalis ATCC 29212, activity value is MIC > 100 ug/ml||Anti-Staphylococcus epidermidis, activity value is MIC > 100 ug/ml||Anti-Enterococcus faecium, activity value is MIC > 100 ug/ml||Anti-Candida albicans CMCC 98001, activity value is MIC > 100 ug/ml||Anti-Candida albicans 1, activity value is MIC > 100 ug/ml||Anti-Candida glabrata, activity value is MIC > 100 ug/ml||Antimicrobial||Anticancer	the black-spotted frog, <>Pelophylax nigromaculata, China, Asia|||Pelophylax nigromaculatus|||Pelophylax nigromaculatus|||the black-spotted frog, <>Pelophylax nigromaculata, China, Asia|||Animalia	N/A	the black-spotted frog, <>Pelophylax nigromaculata, China, Asia|||Mouse erythrocytes (7.5% Hemolysis at 200 ug/ml|||Mouse erythrocytes (7.5% Hemolysis at 200 ug/ml	"2021 Mar:116:103928. doi: 10.1016/j.dci.2020.103928. Epub 2020 Nov 24.|||Dev Comp Immunol
. 2021 Mar:116:103928. doi: 10.1016/j.dci.2020.103928. Epub 2020 Nov 24.|||33242568|||33242568|||Dev Comp Immunol
. 2021 Mar:116:103928. doi: 10.1016/j.dci.2020.103928. Epub 2020 Nov 24.|||Dev Comp Immunol. 2021 Mar;116:103929."	29	
FPDB01531	AP03449|||AP03449|||PN5	FKFLARTGKFL	Anti-foodborne bacteria Gram+ S. aureus ATCC25923, activity value is MIC = 32 ug/ml||Anti-L. monocytogenes KCTC3710, activity value is MIC = 32 ug/ml||Anti-B. subtilis KCTC 2217, activity value is MIC = 5.3 ug/ml||Anti-S. typhimurium KCTC1926, activity value is MIC = 64 ug/ml||Anti-P. aeruginosa ATCC 27853, activity value is MIC = 5.3 ug/ml||Anti-and A. baumannii KCTC 2508, activity value is MIC = 5.3 ug/ml||Anti-MIC of peptide without C terminal modification: [Staphylococcus aureus ATCC25923, activity value is MIC = 32||Anti-Listeria monocytogenes KCTC3710, activity value is MIC = 32||Anti-Escherichia coli ATCC25922, activity value is MIC = 64||Anti-Salmonella typhimurium KCTC1926, activity value is MIC = 64||Anti-MIC of peptide with C terminal NH2: [Staphylococcus aureus ATCC25923, activity value is MIC = 16||Anti-Salmonella typhimurium KCTC1926, activity value is MIC = 32||Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis||Antibiofilm	Pine Needles,Pinus densiflora Sieb. et Zucc.|||Synthetic construct	Helix	"Pine Needles,Pinus densiflora Sieb. et Zucc.||At the effective antibacterial concentrations (MIC = 32–64 ug/ml), the hemolysis rate was < 1%, with no significant red blood cell damage observed.|||Pine Needles,Pinus densiflora Sieb. et Zucc.||The toxicity of the AMPs against eukaryotic cells was evaluated based on their lytic ability at tested concentrations (0–200 ug/ml; Figure 5A). The percentage of hemolysis was determined by measuring the amount of mouse hemoglobin released after incubation with PN-#5, PN-#7, PN-#8, PN-#10, or melittin (the reference AMP). The PN peptides did not cause hemolysis even at a concentration of 200 ug/ml. In contrast, melittin induced hemolysis even at the lowest concentration (3 ug/ml). The cytotoxicity of the peptides against RAW264.7 murine macrophages and HaCaT keratinocytes is shown in Figures 5B,C, respectively. The PN peptides at a concentration of 200 ug/ml caused less than 20% cytotoxicity in the RAW264.7 and HaCaT cell lines. These results suggested that the PN peptides are not toxic in the MIC range. In contrast, melittin, the reference AMP, caused 100% lysis at a concentration of 12.5 ug/ml (Figures 5B,C).|||Mouse RBC (5% hemolysis at 200 ug/ml)|||The core hemolytic data of antimicrobial peptides (PN peptides) isolated from red pine (Pinus densiflora) needles and their synthetic analogs in the document are as follows. The test subject was mouse red blood cells (mRBCs), and the key indicator was the hemolysis rate at different concentrations:

1. Naturally purified antimicrobial peptides (PN-#5, PN-#7, PN-#8, PN-#10)

Test concentration range: 0–200 µg/ml (covering their minimum inhibitory concentrations (MIC) against foodborne bacteria: 8–128 µg/ml).
Hemolysis results: At the highest test concentration of 200 µg/ml, none of the four natural PN peptides showed detectable hemolytic activity (hemolysis rate 0%), with no significant difference compared to the negative control (PBS).
Control comparison: Positive control melittin (bee venom peptide) induced hemolysis at a low concentration (3 µg/ml), highlighting the low toxicity advantage of PN peptides.

2. Synthetic antimicrobial peptides (PN5, PN5-NH₂)

Two peptides synthesized based on the N-terminal sequence of natural PN-#5 (FKFLARTGKFL), with hemolysis data as follows:

PN5 (non-amidated): At 200 µg/ml, the hemolysis rate was only about 5%, consistent with the toxicity of natural PN-#5.
PN5-NH₂ (C-terminal amidation): Specific hemolysis rates were not listed individually, but experiments showed that its toxicity trend was consistent with PN5 — no significant hemolysis within the MIC range (16–64 µg/ml), and maintained low hemolysis at the high concentration of 200 µg/ml (comparable to the natural peptide).

Supplementary Notes

Control settings: Negative control (PBS) hemolysis rate was 0%, positive control (0.1% Triton X-100) hemolysis rate was 100%, all data calibrated accordingly.
Key conclusion: All PN peptides (natural and synthetic) showed no hemolytic activity at concentrations effective against foodborne bacteria (8–128 µg/ml). Even at the high concentration of 200 µg/ml, they maintained very low hemolysis rates, with cytotoxicity to human keratinocytes (HaCaT) and mouse macrophages (RAW264.7) below 20%, providing a safety basis for applications in the food industry and pharmaceuticals.|||At the effective antibacterial concentrations (MIC = 32–64 ug/ml), the hemolysis rate was < 1%, with no significant red blood cell damage observed.|||The toxicity of the AMPs against eukaryotic cells was evaluated based on their lytic ability at tested concentrations (0–200 ug/ml; Figure 5A). The percentage of hemolysis was determined by measuring the amount of mouse hemoglobin released after incubation with PN-#5, PN-#7, PN-#8, PN-#10, or melittin (the reference AMP). The PN peptides did not cause hemolysis even at a concentration of 200 ug/ml. In contrast, melittin induced hemolysis even at the lowest concentration (3 ug/ml). The cytotoxicity of the peptides against RAW264.7 murine macrophages and HaCaT keratinocytes is shown in Figures 5B,C, respectively. The PN peptides at a concentration of 200 ug/ml caused less than 20% cytotoxicity in the RAW264.7 and HaCaT cell lines. These results suggested that the PN peptides are not toxic in the MIC range. In contrast, melittin, the reference AMP, caused 100% lysis at a concentration of 12.5 ug/ml (Figures 5B,C)."	"2021 May 20:12:662462. doi: 10.3389/fmicb.2021.662462. eCollection 2021|||Front Microbiol. 2021 May 20;12:662462. doi: 10.3389/fmicb.2021.662462. PubMed|||Front Microbiol
. 2021 May 20:12:662462. doi: 10.3389/fmicb.2021.662462. eCollection 2021.|||34093476|||Front Microbiol. 2021 May 20;12:662462. doi: 10.3389/fmicb.2021.662462. PubMed|||Front Microbiol. 2021 May 20;12:662462. doi: 10.3389/fmicb.2021.662462. PubMed|||Front Microbiol
. 2021 May 20:12:662462. doi: 10.3389/fmicb.2021.662462. eCollection 2021."	11	
FPDB01532	AP03469	KFDLKVTIK	Anti-Gram- E. coli EHEC O157:H7, activity value is MIC = 32 uM||Anti-K. pneumoniae KPC, activity value is MIC = 64 uM||Anti-A. baumanii, activity value is MIC = 128 uM||Anti-but not active against Gram+ S.aureus MDR, activity value is MIC > 128 uM||Anti-E. faecalis, activity value is MIC > 128 uM	other methods predicted, human proteome, Homo sapiens, human, primates, mammals, animals|||other methods predicted, human proteome, Homo sapiens, human, primates, mammals, animals|||human proteome, Homo sapiens, human, primates, mammals, animals	N/A	other methods predicted, human proteome, Homo sapiens, human, primates, mammals, animals|||human proteome, Homo sapiens, human, primates, mammals, animals	"2022 Oct 18;23(20):12480. doi: 10.3390/ijms232012480.|||Biochim Biophys Acta Gen Subj. 2022 Oct 21:130265. doi: 10.1016/j.bbagen.2022.130265. PubMed|||Int J Mol Sci
. 2022 Oct 18;23(20):12480. doi: 10.3390/ijms232012480."	9	
FPDB01533	AP03497	NCNFLCKVKQRLRSVSSTSHIGMAIPRPRG	Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis||Anti-Gram+ bacteria S. haemolyticus 13A13770, activity value is MIC = 3.125 ug/ml||Anti-S. aureus ATCC25923, activity value is MIC = 12.5 ug/ml||Anti-E. faecalis ATCC29212, activity value is MIC = 50 ug/ml||Anti-A. junii 13A15578, activity value is MIC = 12.5 ug/ml||Anti-K. pneumoniae 0813343, activity value is MIC = 25 ug/ml||Anti-and Sal. paratyphi A, activity value is MIC = 50 ug/ml	Skin, the frog, Nanorana ventripunctata, Yunnan, China, Asia|||Skin, the frog, Nanorana ventripunctata, Yunnan, China, Asia	N/A	Skin, the frog, Nanorana ventripunctata, Yunnan, China, Asia||300 ug/ml of Nv-CATH exerts no hemolytic effect on rabbit red blood cells.|||not hemo.lytic at 300 ug/ml to rabbit RBC. not toxic to mouse peritoneal macrophage (MPMs) and bone-marrow-derived neutrophils (BMDNs) at 100 ug/ml.|||300 ug/ml of Nv-CATH exerts no hemolytic effect on rabbit red blood cells.	2022 Dec 9;8(12):2464-2479. doi: 10.1021/acsinfecdis.2c00260. Epub 2022 Nov 15.|||ACS Infect Dis. 2022 Dec 9;8(12):2464-2479. doi: 10.1021/acsinfecdis.2c00260. PubMed|||ACS Infect Dis. 2022 Dec 9;8(12):2464-2479. doi: 10.1021/acsinfecdis.2c00260. PubMed|||ACS Infect Dis. 2022 Dec 9;8(12):2464-2479. doi: 10.1021/acsinfecdis.2c00260. PubMed	30	
FPDB01534	AP03615|||AP03615|||Mini-ChBac7.5N alpha|||DRAMP20786|||Mini-ChBac7.5N alpha|||AP03615|||DRAMP20786	RRLRPRRPRLPRPRPRPRPRPR	Anti-or M17, activity value is MIC = 1||Anti-clincla strains, activity value is MIC = 2 uM||Anti-Klebsiella spp. clinical isolate, activity value is MIC = 4 uM||Anti-A. baumannii clinical isolate, activity value is MIC = 2 uM||Anti-L. monocytogenes EGD, activity value is MIC = 2 uM||Anti-M. luteus CIP A270, activity value is MIC = 1 uM||Anti-S-aureus ATCC 25923 or 710A or MRSA, activity value is MIC > 64 uM||Anti-S-intermedius clin. isolate, activity value is MIC > 64 uM||Anti-C. albicans 820, activity value is MIC = 64 uM||Anti-and C-parapsilosis, activity value is MIC > 64 uM||Antibacterial||Antifungal||Anti-E.coli, activity value is MIC = 0.3||activity value is MIC = 1.5||activity value is MIC = 1 uM||Anti-E.coli, activity value is MIC = 0.6||activity value is MIC = 0.9||activity value is MIC = 2 uM||Anti-E.coli, activity value is MIC = 0.5||activity value is MIC = 0.8||Anti-Pseudomonas aeruginosa, activity value is MIC = 1.1||activity value is MIC = 3.7||Anti-Pseudomonas aeruginosa clinical isolate, activity value is MIC = 2 uM||Anti-Acinetobacter baumannii clinical isolate, activity value is MIC = 2 uM||Anti-Listeria monocytogenes, activity value is MIC = 0.2||activity value is MIC = 1||Anti-Micrococcus luteus CIP A270, activity value is MIC = 1 uM||Anti-Staphylococcus aureus, activity value is MIC = 0.7||activity value is MIC > 50 uM||activity value is MIC > 64 uM||Anti-Staphylococcus aureus, activity value is MIC > 64 uM||Anti-MRSA, activity value is MIC = 0.7||Anti-Staphylococcus intermedius clin. isolate, activity value is MIC > 64 uM||Anti-Candida albicans, activity value is MIC = 0.3||activity value is MIC = 64 uM||Anti-Candida parapsilosis clinical isolate, activity value is MIC > 64 uM||Anti-E.coli ML35p, activity value is MIC = 1||Anti-E.coli ATCC 25922, activity value is MIC = 2 uM||Anti-E.coli M17, activity value is MIC = 2 uM||Anti-Pseudomonas aeruginosa ATCC 27853, activity value is MIC = 2 uM||Anti-Acinetobacter baumannii clinical isolate, activity value is MIC = 2||Anti-Listeria monocytogenes EGD, activity value is MIC = 2 uM||Anti-Candida albicans 820, activity value is MIC = 64 uM||Anti-##Gram-positive bacteria:Listeria monocytogenes, activity value is MIC = 0.2||Anti-##Fungi:Candida albicans, activity value is MIC = 0.3||Anti-the R7A analog appeared to be slightly more active, activity value is MIC = 4 uM||Anti-the P8A analog became 8 fold less active, activity value is MIC = 64 uM	neutrophils, domestic goat, Capra hircus|||neutrophils, domestic goat, Capra hircus|||Capra hircus [Goat]|||Capra hircus|||neutrophils, domestic goat, Capra hircus|||Capra hircus|||neutrophils, domestic goat, Capra hircus	Rich	neutrophils, domestic goat, Capra hircus||In the concentration range of 1-100 uM, there is no significant hemolytic effect on human red blood cells.|||not hemo.lytic till 100 uM. No toxicity to other mammalian cells tested till 30 uM.|||E.coli ML35p(MIC=1micoM) , E.coli ATCC 25922(MIC=2 uM), E.coli M17(MIC=2 uM), Pseudomonas aeruginosa ATCC 27853(MIC=2 uM), Pseudomonas aeruginosa clinical isolate(MIC=2 uM), Klebsiella spp. clinical isolate(MIC=4 uM), Acinetobacter baumannii clinical isolate(MIC=2microm), Listeria monocytogenes EGD(MIC=2 uM),Micrococcus luteus CIP A270(MIC=1 uM), Staphylococcus aureus 710A(MIC=>64 uM), Staphylococcus aureus ATCC 25923(MIC=>64 uM), MRSA ATCC 33591(MIC=>64 uM), Staphylococcus intermedius clin. isolate(MIC=>64 uM), Candida albicans 820(MIC=64 uM), Candida parapsilosis clinical isolate(MIC=>64 uM)|||No hemolytic activity against human erythrocytes|||In the concentration range of 1-100 uM, there is no significant hemolytic effect on human red blood cells.|||not hemo.lytic till 100 uM. No toxicity to other mammalian cells tested till 30 uM.|||[Ref.27818338] No hemolytic activity|||not hemo.lytic till 100 uM.	2016 Jul-Sep;8(3):136-146.|||Acta Naturae. 2016 Jul-Sep;8(3):136-146. Pub-Med.|||Acta Naturae. 2016 Jul-Sep;8(3):136-146. Pub-Med.|||27795854|||Acta Naturae. 2016 Jul-Sep;8(3):136-146.||Ref.27795854|||27795854|||Acta Naturae. 2016 Jul-Sep;8(3):136-146. Pub-Med.|||Acta Naturae. 2016 Jul-Sep;8(3):136-146.||Ref.27795854|||Acta Naturae. 2016 Jul-Sep;8(3):136-146. Pub-Med.||Bolosov et al., 2023	22	
FPDB01535	AP03752|||AP03752|||AP03755|||Bac7	RRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFP	Anti-Gram+ & Gram-||Anti-inflammatory||anti-sepsis||Anti-Gram-||Antifungal||Antiparasitic||Antibacterial||Anti-parasite C. parvum in the form sporozoite but not oocyst. Active against E. coli ATCC 25922 or ML-35, activity value is MIC = 0.5 uM||Anti-S. enterica serovar Typhimurium ATCC 14028, activity value is MIC = 0.5 uM||Anti-S. marcescens ATCC8100, activity value is MIC = 1 uM||Anti-K. pneumoniae 13 clinical strains, activity value is MIC = 0.25||Anti-A. baumannii (12 clinical strains, activity value is MIC = 0.5||Anti-P. aeruginosa 20 clinical strains, activity value is MIC = 0.5||Anti-B-cepacia 10 clinical strains, activity value is MIC > 64 uM||Anti-S.aureus ATCC 25923, activity value is MIC > 128 uM||Anti-C. neoformans, activity value is MIC = 1||Anti-P-etchellsii, activity value is MIC > 32 uM||Anti-and C-albicans, activity value is MIC > 64 uM	Sequence truncation, animal-derived, natural derivative|||Sequence truncation, animal-derived, natural derivative|||Bos taurus [Bovine]	Nonhelixbeta||Rich	N/A	J Antimicrob Chemother. 2003 Apr;51(4):843-7. doi: 10.1093/jac/dkg149|||J Antimicrob Chemother. 2003 Apr;51(4):843-7. doi: 10.1093/jac/dkg149. 12654759.|||Peptides. 2004 Dec;25(12):2055-61. doi: 10.1016/j.peptides.2004.08.004. 15572192.|||35254120|||J Antimicrob Chemother. 2003 Apr;51(4):843-7. doi: 10.1093/jac/dkg149. 12654759.||Benincasa et al., 2004	35	
FPDB01536	AP04087	KIAKRIWKRIWKILRRR	Anti-E. coli, activity value is MIC = 31 ug/ml||Anti-P. aeruginosa ATCC27853 or 14 MDR clinical strains, activity value is MIC = 3.91||Anti-K. pneumonia, activity value is MIC = 16 ug/ml||Anti-E. faecium, activity value is MIC = 4 ug/ml||Anti-S. aureus, activity value is MIC = 2 ug/ml||Anti-and C. acnes, activity value is MIC = 16 ug/ml	hybrid peptide, designed	N/A	"P7A3 (heteropeptide): At a concentration of 62.5 μg/ml, the hemolysis rate of human red blood cells was 100%;
PA-18 (P7A3 truncated form): Hemolytic activity was reduced compared to P7A3, specific values were not clarified, but it suggests that the five amino acids at positions 19-23 of the C-terminus are crucial for the hemolytic activity of P7A3;
PA-13 (shortest truncated form): At effective antibacterial concentrations (MIC), the hemolysis rate of human red blood cells was <2%;
Positive control (melittin): At a concentration of 1.95 μg/ml, it caused complete hemolysis (100%) of human red blood cells;
Parent peptides P0, A0: At the highest tested concentration (250 μg/ml), the hemolysis rate was <5%."	2020 Jun 4;10(1):9117. doi: 10.1038/s41598-020-65688-5.|||Sci Rep. 2020 Jun 4;10(1):9117. doi: 10.1038/s41598-020-65688-5. PubMed	17	
FPDB01537	AP04246	MFMAIVVLAALMVLPQVEGGCWEIWSRCTGWSSWGTGRLWKSCSDRCKELGKSGGRCVLKDASDCWMTDQAGQYVCNRRT	Anti-Gram+ S-aureus, activity value is MIC > 16 uM||Anti-V. anguillarum, activity value is MIC = 0.5||Anti-V. alginolyticus, activity value is MIC = 1||Anti-V. parahemolyticus, activity value is MIC = 2||Anti-E. cloacae, activity value is MIC = 1||Anti-E. coli, activity value is MIC = 1||Anti-and P. mirabidis, activity value is MIC = 2||Anti-Gram-||anti-sepsis	Pacific abalone, Haliotis discus hannai|||Pacific abalone, Haliotis discus hannai	N/A	N/A	2024 Jun:204:108113. doi: 10.1016/j.jip.2024.108113. Epub 2024 Apr 1|||J Invertebr Pathol. 2024 Apr 15:108113. doi: 10.1016/j.jip.2024.108113. PubMed	80	
FPDB01538	AP04636|||AP04636|||CAMPSQ15267|||DRAMP21151	"	
LRIVKLILKWLR"	Anti-Gram- E. coli KCTC 1682, activity value is MIC = 4 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 8 uM||Anti-S. typhimurium KCTC 1926, activity value is MIC = 4 uM||Anti-B. subtilis KCTC 3068, activity value is MIC = 4 uM||Anti-S. epidermidis KCTC 1917, activity value is MIC = 1 uM||Anti-and S. aureus KCTC 1621, activity value is MIC = 4 uM||Anti-Gram- E. coli KCTC 1682, activity value is MIC = 16 uM||Anti-P. aeruginosa KCTC 1637, activity value is MIC = 16 uM||Anti-B. subtilis KCTC 3068, activity value is MIC = 8 uM||Anti-S. epidermidis KCTC 1917, activity value is MIC = 2 uM||Antibacterial||Anti-Bacillus subtilis, activity value is MIC = 8 uM||Anti-Staphylococcus epidermidis, activity value is MIC = 2 uM||Anti-Staphylococcus aureus, activity value is MIC = 4 uM||Anti-##Gram-negative bacteria : Escherichia coli, activity value is MIC = 16 uM||Anti-Pseudomonas aeruginosa, activity value is MIC = 16 uM||Anti-Salmonella typhimurium, activity value is MIC = 4 uM	amino acid substitution, human cathelicidin analog, animal-derived, natural derivative|||amino acid substitution, human cathelicidin analog, animal-derived, natural derivative|||Synthetic construct|||Synthetic construct	Helix||Random coil, alpha helix	"KR-12-a5: 50% hemolytic concentration (HC₅₀) is 96 μM; 
KR-12-a6: 50% hemolytic concentration (HC₅₀) is 22 μM; 
KR-12, KR-12-a1, KR-12-a2, KR-12-a3, KR-12-a4, KR-12-a7, KR-12-a8: did not reach 50% hemolysis at the highest tested concentration (800 μM) (HC₅₀ > 800 μM); 
Positive control (LL-37): 50% hemolytic concentration (HC₅₀) is 175 μM.|||human RBC (HC50 22 uM), hemolytic.|||hRBC ( HC50= 22 uM)|||[Ref.24105706] HC50=22 uM against human red blood cells"	2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. Epub 2013 Sep 17.|||J Pept Sci. 2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. PubMed|||24105706|||J Pept Sci. 2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.||Ref.24105706	12	
FPDB01539	AP04637|||AP04638	HELIX	2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. Epub 2013 Sep 17.	N/A	active against Gram- E. coli KCTC 1682 (MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Non-standard assay.	"KR-12-a5: 50% hemolytic concentration (HC₅₀) is 96 μM; 
KR-12-a6: 50% hemolytic concentration (HC₅₀) is 22 μM; 
KR-12, KR-12-a1, KR-12-a2, KR-12-a3, KR-12-a4, KR-12-a7, KR-12-a8: did not reach 50% hemolysis at the highest tested concentration (800 μM) (HC₅₀ > 800 μM); 
Positive control (LL-37): 50% hemolytic concentration (HC₅₀) is 175 μM."	amino acid substitution, human cathelicidin analog, animal-derived, natural derivative	5	
FPDB01540	AP01130|||AP01130|||PGLa-AM1|||PGLa- AN1|||PGLa- AN1	GMASKAGSVLGKVAKVALKAAL	Anti-Gram+ & Gram-||anti-diabetes||anti-sepsis||Antibacterial||Antifungal	skin secretions, the octoploid frog, Xenopus amieti (Pipidae), Africa|||skin secretions, the octoploid frog, Xenopus amieti (Pipidae), Africa|||Xenopus amieti [Volcano clawed frog]|||Xenopus amieti|||Xenopus andrei	N/A	L. plantarum WCFS1 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. rhamnosus LGG [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. salivarius DSM20554 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. salivarius FortaFit Ls-33 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. casei R0215 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. casei Shirtota [MIC = 250 ug/ml] [MBC = >250 ug/ml], L. johnsonii LC-1 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. reuteri ATCC5730 [MIC = >250 ug/ml] [MBC = >250 ug/ml], L. acidophilus LA5 [MIC = >250 ug/ml] [MBC = >250 ug/ml], S. aureus DMS20231 [MIC = 64 ug/ml] [MBC = 250 ug/ml], S. aureus Sens 8325.4 [MIC = <8 ug/ml] [MBC = 128 ug/ml], S. aureus MRSA B33424 [MIC = <8 ug/ml] [MBC = 128 ug/ml], S. pseudintermedium E138 [MIC = <8 ug/ml] [MBC = 128 ug/ml], S. pseudintermedium E139 [MIC = <8 ug/ml] [MBC =250 ug/ml], S. pseudintermedium E140 [MIC = <8 ug/ml] [MBC = 250 ug/ml], S. pseudintermedium S70E2 [MIC = <8 ug/ml] [MBC = 128 ug/ml], P. aeruginosa 26228 [MIC = >256 ug/ml] [MBC = >256 ug/ml], P. aeruginosa 25467 [MIC = >256 ug/ml] [MBC = >256 ug/ml], P. aeruginosa Sens1 PA01 [MIC = >256 ug/ml] [MBC = >256 ug/ml], P. aeruginosa Sens 2 ATCC27853 [MIC = 64 ug/ml] [MBC = 64 ug/ml], P. aeruginosa MDR1 B38084 [MIC = >256 ug/ml] [MBC = >256 ug/ml], P. aeruginosa MDR2 B31770 [MIC = >256 ug/ml] [MBC = >256 ug/ml], E. faecium Sens S1 [MIC = >256 ug/ml] [MBC = >256 ug/ml], E. faecium Sens S2 [MIC = >256 ug/ml] [MBC = >256 ug/ml], E. faecium VanA R39 [MIC = 128 ug/ml] [MBC = 128 ug/ml], E. faecium VanB R44 [MIC = >256 ug/ml] [MBC = >256 ug/ml], A. baumannii MDR Bangl 027 [MIC = 256 ug/ml] [MBC = 256 ug/ml]	Peptides. 2010 Jun;31(6):989-94|||Peptides. 2010 Jun;31(6):989-94.|||20226221|||31102497|||21498136|||21498136	22